Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UGT1A9	0	broad.mit.edu	37	2	234581137	234581137	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:234581137C>A	ENST00000354728.4	+	1	639	c.557C>A	c.(556-558)cCt>cAt	p.P186H	UGT1A10_ENST00000344644.5_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		TGCCCTGCTCCTCTTTCCTAT	0.473000													7	166					1.06961e-07	1.12439e-07	1	1	0
TRABD	80305	broad.mit.edu	37	22	50635672	50635672	+	Silent	SNP	C	C	T	rs144093601		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50635672C>T	ENST00000303434.4	+	6	542	c.423C>T	c.(421-423)aaC>aaT	p.N141N	TRABD_ENST00000395829.1_Silent_p.N141N|TRABD_ENST00000380909.4_Silent_p.N141N|TRABD_ENST00000395827.1_Silent_p.N141N	NM_025204.2	NP_079480.2	Q9H4I3	TRABD_HUMAN	TraB domain containing	141										breast(1)|central_nervous_system(1)|large_intestine(1)|liver(2)|lung(1)|upper_aerodigestive_tract(1)	7		all_cancers(38;1.07e-07)|all_epithelial(38;9.6e-07)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		LUAD - Lung adenocarcinoma(64;0.105)		CTCTGCAGAACGGGCTCATGT	0.662000													18	22					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52668639	52668639	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52668639G>A	ENST00000356770.4	-	10	1186	c.1184C>T	c.(1183-1185)cCc>cTc	p.P395L	PBRM1_ENST00000409767.1_Missense_Mutation_p.P427L|PBRM1_ENST00000409057.1_Missense_Mutation_p.P427L|PBRM1_ENST00000394830.3_Missense_Mutation_p.P427L|PBRM1_ENST00000410007.1_Missense_Mutation_p.P427L|PBRM1_ENST00000409114.3_Missense_Mutation_p.P427L|PBRM1_ENST00000337303.4_Missense_Mutation_p.P427L|PBRM1_ENST00000296302.7_Missense_Mutation_p.P427L			Q86U86	PB1_HUMAN	polybromo 1	427					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TAGTGATATGGGCATTTTAAT	0.353000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								22	41					0	0	1	0	0
VPS28	51160	broad.mit.edu	37	8	145651576	145651576	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145651576G>A	ENST00000377348.2	-	3	142	c.53C>T	c.(52-54)cCg>cTg	p.P18L	VPS28_ENST00000529182.1_Missense_Mutation_p.P18L|VPS28_ENST00000526734.1_5'UTR|VPS28_ENST00000526054.1_Missense_Mutation_p.P18L|VPS28_ENST00000292510.4_Missense_Mutation_p.P18L	NM_183057.1	NP_898880.1	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 homolog (S. cerevisiae)	18	VPS28 N-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			ATACAGCTCCGGCTTGTTCCC	0.627000													6	2					0	0	1	0	0
POGZ	23126	broad.mit.edu	37	1	151396613	151396613	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151396613T>C	ENST00000271715.2	-	9	1649	c.1335A>G	c.(1333-1335)tcA>tcG	p.S445S	POGZ_ENST00000368863.2_Silent_p.S350S|POGZ_ENST00000361398.3_Silent_p.S392S|POGZ_ENST00000392723.1_Silent_p.S392S|POGZ_ENST00000409503.1_Silent_p.S436S|POGZ_ENST00000540984.1_Intron|POGZ_ENST00000491586.1_Silent_p.S392S|POGZ_ENST00000531094.1_Silent_p.S383S	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	445					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGGTAGGCGGTGACAGAGCAG	0.512000													32	60					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86541553	86541553	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:86541553C>T	ENST00000450689.2	-	15	2189	c.2004G>A	c.(2002-2004)tcG>tcA	p.S668S	KIAA1324L_ENST00000416314.1_Silent_p.S501S|KIAA1324L_ENST00000297222.6_Silent_p.S428S|KIAA1324L_ENST00000444627.1_Intron	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	668						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					TATAGCAAACCGAATGGTCCT	0.338000													44	89					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241683366	241683366	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:241683366C>T	ENST00000498729.2	-	33	3823	c.3577G>A	c.(3577-3579)Gtg>Atg	p.V1193M	KIF1A_ENST00000320389.7_Missense_Mutation_p.V1092M	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1092					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		AACCTGAGCACGTCCTTGCAG	0.587000													21	36					0	0	1	0	0
SOX14	8403	broad.mit.edu	37	3	137483730	137483730	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:137483730A>G	ENST00000306087.1	+	1	152	c.104A>G	c.(103-105)aAc>aGc	p.N35S		NM_004189.3	NP_004180.1	O95416	SOX14_HUMAN	SRY (sex determining region Y)-box 14	35					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding			large_intestine(2)|lung(12)	14						AAGATGCACAACTCGGAGATC	0.592000													6	6					0	0	1	0	0
NOL12	79159	broad.mit.edu	37	22	38084897	38084897	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38084897G>A	ENST00000359114.4	+	4	349	c.279G>A	c.(277-279)acG>acA	p.T93T	RP1-37E16.12_ENST00000455236.1_RNA|NOL12_ENST00000493862.1_3'UTR	NM_024313.2	NP_077289.1	Q9UGY1	NOL12_HUMAN	nucleolar protein 12	93						nucleolus	rRNA binding	p.T93T(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	8	Melanoma(58;0.0574)					CAGCAAAGACGGAGTCGGTGC	0.637000													35	49					0	0	1	0	0
TK2	7084	broad.mit.edu	37	16	66584027	66584027	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:66584027C>T	ENST00000299697.7	-	1	288	c.64G>A	c.(64-66)Gca>Aca	p.A22T	TK2_ENST00000544898.1_5'UTR|Y_RNA_ENST00000563151.1_lincRNA|TK2_ENST00000527284.1_Intron|TK2_ENST00000417693.3_5'UTR|TK2_ENST00000451102.2_5'UTR	NM_001172644.1|NM_001172645.1|NM_001271934.1|NM_001271935.1|NM_001272050.1|NM_004614.4	NP_001166115.1|NP_001166116.1|NP_001258863.1|NP_001258864.1|NP_001258979.1|NP_004605.4	O00142	KITM_HUMAN	thymidine kinase 2, mitochondrial	0					pyrimidine base metabolic process|pyrimidine nucleoside salvage	mitochondrial matrix	ATP binding|phosphotransferase activity, alcohol group as acceptor|thymidine kinase activity			large_intestine(1)|lung(2)|urinary_tract(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0736)|Epithelial(162;0.237)		CGGACGACTGCTAGTCCAGCC	0.677000													3	6					0	0	1	0	0
MYEOV2	150678	broad.mit.edu	37	2	241069404	241069404	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:241069404A>G	ENST00000307266.3	-	4	304	c.305T>C	c.(304-306)gTt>gCt	p.V102A		NM_138336.1	NP_612209.1	Q8WXC6	MYOV2_HUMAN	myeloma overexpressed 2	0										breast(1)|lung(5)|pancreas(1)	7		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		CAGTGCGGGAACCATGGAGGA	0.602000													9	17					0	0	1	0	0
TICAM2	353376	broad.mit.edu	37	5	114916761	114916761	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:114916761C>T	ENST00000408996.4	-	4	1086	c.700G>A	c.(700-702)Gtg>Atg	p.V234M	TMED7-TICAM2_ENST00000333314.3_3'UTR|TMED7-TICAM2_ENST00000282382.4_Missense_Mutation_p.V234M|TICAM2_ENST00000427199.2_Missense_Mutation_p.V65M	NM_001164468.2|NM_001164469.2	NP_001157940.1|NP_001157941.1			toll-like receptor adaptor molecule 2											cervix(1)|kidney(1)|lung(2)|soft_tissue(1)	5		all_cancers(142;0.0223)|all_epithelial(76;0.000869)|Prostate(80;0.0115)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;4.38e-07)|Epithelial(69;1.62e-06)|all cancers(49;6.93e-05)		ATCTCTTCCACGCTCTGAGCT	0.458000													69	128					0	0	1	0	0
ZNF609	23060	broad.mit.edu	37	15	64970399	64970399	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:64970399C>T	ENST00000326648.3	+	5	3615	c.3487C>T	c.(3487-3489)Cgg>Tgg	p.R1163W		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	1163						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAAGGAGGAGCGGGACCGCAA	0.527000													10	24					0	0	1	0	0
UBIAD1	29914	broad.mit.edu	37	1	11345737	11345737	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11345737T>C	ENST00000376810.5	+	2	892	c.566T>C	c.(565-567)aTc>aCc	p.I189T	UBIAD1_ENST00000376804.2_Intron	NM_013319.2	NP_037451.1	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	189					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		GGAGACCTCATCATCCTCATC	0.562000													10	18					0	0	1	0	0
PRKAR2A	5576	broad.mit.edu	37	3	48820520	48820520	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48820520C>A	ENST00000265563.8	-	5	690	c.441G>T	c.(439-441)caG>caT	p.Q147H	PRKAR2A_ENST00000296446.8_Missense_Mutation_p.Q147H|PRKAR2A_ENST00000454963.1_Missense_Mutation_p.Q147H	NM_004157.2	NP_004148.1	P13861	KAP2_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, alpha	147					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity		SLC26A6/PRKAR2A(2)	breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		CTTGAGAAAGCTGTTCCTGCA	0.373000													23	27					2.21704e-12	2.3975e-12	1	1	0
TCF4	6925	broad.mit.edu	37	18	52899844	52899844	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:52899844G>A	ENST00000354452.3	-	17	2156	c.1545C>T	c.(1543-1545)tcC>tcT	p.S515S	TCF4_ENST00000561831.3_Silent_p.S355S|TCF4_ENST00000537578.1_Silent_p.S491S|TCF4_ENST00000561992.1_Silent_p.S385S|TCF4_ENST00000568740.1_Silent_p.S490S|TCF4_ENST00000570287.2_Silent_p.S355S|TCF4_ENST00000537856.3_Silent_p.S385S|TCF4_ENST00000568673.1_Silent_p.S491S|TCF4_ENST00000567880.1_Silent_p.S455S|TCF4_ENST00000565018.2_Silent_p.S515S|TCF4_ENST00000566279.1_Silent_p.S455S|TCF4_ENST00000564228.1_Silent_p.S444S|TCF4_ENST00000564999.1_Silent_p.S515S|TCF4_ENST00000544241.2_Silent_p.S444S|TCF4_ENST00000543082.1_Silent_p.S473S|TCF4_ENST00000540999.1_Silent_p.S491S|TCF4_ENST00000398339.1_Silent_p.S617S|TCF4_ENST00000570177.2_Silent_p.S385S|TCF4_ENST00000566286.1_Silent_p.S512S|TCF4_ENST00000356073.4_Silent_p.S515S|TCF4_ENST00000457482.3_Silent_p.S355S|TCF4_ENST00000564403.2_Silent_p.S521S	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	515					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		CCTCGTCATCGGATTTGATCT	0.463000													20	35					0	0	1	0	0
FMOD	2331	broad.mit.edu	37	1	203311497	203311497	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:203311497G>A	ENST00000354955.4	-	3	1568	c.1105C>T	c.(1105-1107)Cgc>Tgc	p.R369C	FMOD_ENST00000464898.1_5'UTR	NM_002023.4	NP_002014.2	Q06828	FMOD_HUMAN	fibromodulin	369					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	17			BRCA - Breast invasive adenocarcinoma(75;0.171)			CTGGCAAGGCGCAGGCAGAGG	0.642000											OREG0014119	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	16					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144999598	144999598	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:144999598C>T	ENST00000367545.3	+	51	7536	c.7536C>T	c.(7534-7536)aaC>aaT	p.N2512N	UTRN_ENST00000367526.4_Silent_p.N67N	NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	2512					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TTGACGGAAACAGGCAGAAGA	0.373000													21	45					0	0	1	0	0
FBLL1	0	broad.mit.edu	37	5	167957368	167957368	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:167957368G>A	ENST00000338333.4	+	1	1248	c.859G>A	c.(859-861)Gcc>Acc	p.A287T																								CACCGCATCCGCCGAGGCTGT	0.602000													11	9					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53453257	53453257	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53453257G>A	ENST00000314250.6	+	18	2122	c.1832G>A	c.(1831-1833)cGg>cAg	p.R611Q	TENC1_ENST00000451358.1_Missense_Mutation_p.R611Q|TENC1_ENST00000546602.1_Missense_Mutation_p.R611Q|TENC1_ENST00000549700.1_Missense_Mutation_p.R611Q|TENC1_ENST00000552570.1_Missense_Mutation_p.R611Q|TENC1_ENST00000379902.3_Missense_Mutation_p.R487Q|TENC1_ENST00000314276.3_Missense_Mutation_p.R621Q	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	611					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						GGCTACTACCGGCCAGAGGGA	0.692000													3	2					0	0	1	0	0
TMEM99	147184	broad.mit.edu	37	17	38991082	38991082	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38991082C>T	ENST00000301665.3	+	3	618	c.314C>T	c.(313-315)tCg>tTg	p.S105L		NM_001195386.1|NM_001195387.1|NM_145274.3	NP_001182315.1|NP_001182316.1|NP_660317.2	Q8N816	TMM99_HUMAN	transmembrane protein 99	105						integral to membrane				cervix(1)|large_intestine(1)|lung(5)|skin(2)|urinary_tract(1)	10		Breast(137;0.000301)				GGTGTTGGCTCGTGGTTGCTC	0.468000													50	68					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105422838	105422838	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:105422838T>C	ENST00000264122.4	-	11	1908	c.1587A>G	c.(1585-1587)tcA>tcG	p.S529S	CBLB_ENST00000405772.1_Silent_p.S529S|CBLB_ENST00000403724.1_Silent_p.S529S|CBLB_ENST00000394027.3_Silent_p.S551S	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	529	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						CTACCTTTGGTGAACCCGTTG	0.403000			Mis S		AML								5	30					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42635356	42635356	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:42635356C>T	ENST00000358131.5	+	3	570	c.362C>T	c.(361-363)gCc>gTc	p.A121V	TOX2_ENST00000423191.1_Missense_Mutation_p.A70V|TOX2_ENST00000372999.1_Missense_Mutation_p.A70V|TOX2_ENST00000341197.3_Missense_Mutation_p.A112V	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			TCCTATCAGGCCATGGACCTC	0.647000													12	16					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22154228	22154228	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:22154228C>T	ENST00000397126.4	-	4	3756	c.3608G>A	c.(3607-3609)gGc>gAc	p.G1203D	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATAGGCTTTGCCACATTCTTC	0.383000													22	50					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	703426	703426	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:703426G>A	ENST00000549091.1	+	11	1300	c.1208G>A	c.(1207-1209)cGc>cAc	p.R403H	WDR90_ENST00000293879.4_Missense_Mutation_p.R403H	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	403										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				GGGGAGCAGCGCTTCTTCCTT	0.682000													11	21					0	0	1	0	0
TCIRG1	10312	broad.mit.edu	37	11	67815372	67815372	+	Missense_Mutation	SNP	C	C	T	rs141474168	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67815372C>T	ENST00000265686.3	+	13	1595	c.1487C>T	c.(1486-1488)aCg>aTg	p.T496M	TCIRG1_ENST00000532635.1_Missense_Mutation_p.T280M	NM_006019.3	NP_006010.2	Q13488	VPP3_HUMAN	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	496					ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(3)|prostate(1)	16						GCCCAGCACACGATGCTTACC	0.682000													26	48					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179989380	179989380	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:179989380G>A	ENST00000367607.3	+	12	2889	c.2471G>A	c.(2470-2472)cGt>cAt	p.R824H		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	824						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						AAACTGGATCGTATTGAAGCC	0.433000													43	81					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101742291	101742291	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:101742291T>C	ENST00000251127.6	-	29	3377	c.3296A>G	c.(3295-3297)gAc>gGc	p.D1099G		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1099						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCCCACATTGTCGAAATTAAA	0.463000													98	137					0	0	1	0	0
FZR1	51343	broad.mit.edu	37	19	3527745	3527745	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3527745C>T	ENST00000441788.2	+	7	823	c.587C>T	c.(586-588)tCg>tTg	p.S196L	FZR1_ENST00000395095.3_Missense_Mutation_p.S196L|FZR1_ENST00000313639.8_Intron	NM_016263.3	NP_057347.2	Q9UM11	FZR_HUMAN	fizzy/cell division cycle 20 related 1 (Drosophila)	196					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			endometrium(1)|kidney(4)|liver(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGACTGGTCGTCCCTCAAT	0.627000													15	18					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95712519	95712519	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:95712519G>A	ENST00000524717.1	-	5	4348	c.3064C>T	c.(3064-3066)Cca>Tca	p.P1022S		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	1022					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				TGCACTGCTGGTGTTAACTGG	0.512000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								13	22					0	0	1	0	0
EMILIN1	11117	broad.mit.edu	37	2	27303628	27303628	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27303628C>T	ENST00000380320.4	+	3	818	c.319C>T	c.(319-321)Cgt>Tgt	p.R107C		NM_007046.3	NP_008977.1	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1	107	EMI.				cell adhesion	collagen		p.R107C(1)		breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(14)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	26	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCTCGCTACCGTGTGGCCTA	0.637000											OREG0014513	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	13					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72267429	72267429	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:72267429C>T	ENST00000438125.1	-	0	444							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										TCTTTCTTCACGTGATCCATA	0.413000													19	45					0	0	1	0	0
IGKV1-5	0	broad.mit.edu	37	2	89247280	89247280	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:89247280G>A	ENST00000496168.1	-	0	195																											GCTGAGCGGGGACCCTCATGT	0.552000													38	65					0	0	1	0	0
CC2D2A	57545	broad.mit.edu	37	4	15602983	15602983	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:15602983C>T	ENST00000424120.1	+	37	5052	c.4798C>T	c.(4798-4800)Cac>Tac	p.H1600Y	CC2D2A_ENST00000389652.5_Missense_Mutation_p.H1492Y|CC2D2A_ENST00000503292.1_Missense_Mutation_p.H1600Y|CC2D2A_ENST00000413206.1_Missense_Mutation_p.H1600Y			Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A	1600					cell projection organization	cilium|microtubule basal body				NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|urinary_tract(2)	32						TGTATACATACACCCATACCC	0.348000													4	26					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43716064	43716064	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:43716064G>A	ENST00000360835.3	-	3	354	c.228C>T	c.(226-228)gaC>gaT	p.D76D	SCUBE1_ENST00000290460.7_Silent_p.D76D	NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	76	EGF-like 2; calcium-binding (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				TCTCACACTCGTCAATGTCTG	0.537000													16	29					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108624992	108624992	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:108624992G>A	ENST00000264047.2	+	8	1243	c.967G>A	c.(967-969)Gtt>Att	p.V323I	SLC5A7_ENST00000409059.1_Missense_Mutation_p.V323I|SLC5A7_ENST00000540517.1_Missense_Mutation_p.V218I	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	323					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	TTTACCAATTGTTCTGCAGTA	0.423000													26	29					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12337557	12337557	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12337557G>A	ENST00000358136.3	+	19	4042	c.3912G>A	c.(3910-3912)acG>acA	p.T1304T	VPS13D_ENST00000356315.4_Silent_p.T1304T	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1304					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGGAGTTGACGTTATCCATGG	0.423000													45	57					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215987212	215987212	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:215987212G>T	ENST00000366943.2	-	49	9991	c.9605C>A	c.(9604-9606)cCt>cAt	p.P3202H	USH2A_ENST00000307340.3_Missense_Mutation_p.P3202H			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3202					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCGATGTCCAGGCTTGGGGTT	0.398000										HNSCC(13;0.011)			12	38					3.27435e-08	3.44876e-08	1	1	0
OCA2	4948	broad.mit.edu	37	15	28260033	28260033	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28260033G>T	ENST00000354638.3	-	9	1088	c.933C>A	c.(931-933)acC>acA	p.T311T	OCA2_ENST00000353809.5_Silent_p.T311T|OCA2_ENST00000382996.2_Silent_p.T311T	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	311					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GGACAGCCTGGGTCTGCTGCA	0.587000									Oculocutaneous Albinism				3	17					0.004672	0.00472505	1	1	0
DDX1	1653	broad.mit.edu	37	2	15770167	15770167	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:15770167G>A	ENST00000381341.2	+	26	2414	c.2025G>A	c.(2023-2025)ccG>ccA	p.P675P	DDX1_ENST00000233084.3_Silent_p.P675P			Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 1	675	Helicase C-terminal.|Necessary for interaction with HNRNPK.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity	p.P675P(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(13)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		AGGTTGAGCCGGATATAAAGG	0.343000													16	88					0	0	1	0	0
SIDT2	51092	broad.mit.edu	37	11	117062993	117062993	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:117062993G>A	ENST00000324225.4	+	20	2427	c.1896G>A	c.(1894-1896)gcG>gcA	p.A632A	SIDT2_ENST00000431081.2_Silent_p.A629A	NM_001040455.1	NP_001035545.1	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2	632						integral to membrane|lysosomal membrane				NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	36	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		GGAACACGGCGTTCTGGATCG	0.622000													24	29					0	0	1	0	0
KLK9	284366	broad.mit.edu	37	19	51507095	51507095	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:51507095C>T	ENST00000376832.4	-	4	501	c.466_splice	c.e4-1	p.A156_splice	CTB-147C22.9_ENST00000594512.1_RNA|KLK9_ENST00000594211.1_Splice_Site_p.A156_splice|KLK9_ENST00000250366.6_Splice_Site_p.A156_splice	NM_012315.1	NP_036447.1	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9	156	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		CTGGAAACAGCGCTGTCAGGG	0.537000													16	26					0	0	1	0	0
C12orf63	0	broad.mit.edu	37	12	97078927	97078927	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:97078927G>A	ENST00000524981.3	+	9	1278	c.1278G>A	c.(1276-1278)ccG>ccA	p.P426P				Q6ZTY8	CL063_HUMAN		400										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						ATTCACCTCCGGGTTTCAAAG	0.473000													19	29					0	0	1	0	0
RFC1	5981	broad.mit.edu	37	4	39344069	39344069	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:39344069G>A	ENST00000381897.1	-	4	360	c.227C>T	c.(226-228)aCg>aTg	p.T76M	RFC1_ENST00000349703.2_Missense_Mutation_p.T76M|RFC1_ENST00000418436.1_5'UTR	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	76					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						TACCTGCAACGTCTCCTCTGA	0.358000													27	45					0	0	1	0	0
ZNF668	79759	broad.mit.edu	37	16	31073037	31073037	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31073037C>T	ENST00000538906.1	-	3	1996	c.1212G>A	c.(1210-1212)tcG>tcA	p.S404S	ZNF668_ENST00000539836.3_Silent_p.S427S|ZNF668_ENST00000535577.1_Silent_p.S404S|ZNF668_ENST00000417110.2_Silent_p.D75D|ZNF668_ENST00000394983.2_Silent_p.S404S|ZNF668_ENST00000300849.4_Silent_p.S404S|ZNF668_ENST00000426488.2_Silent_p.S427S	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						TCAGGCTCGACGACACCACAA	0.667000													5	108					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53573719	53573719	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:53573719T>C	ENST00000025008.5	-	10	2004	c.1481A>G	c.(1480-1482)cAg>cGg	p.Q494R	RB1CC1_ENST00000435644.2_Missense_Mutation_p.Q494R|RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000539297.1_Missense_Mutation_p.Q494R	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	494					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				GCAGTACATCTGAGGAACTGT	0.373000													5	80					0	0	1	0	0
FCHSD2	9873	broad.mit.edu	37	11	72554562	72554562	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:72554562C>T	ENST00000409314.1	-	16	1699	c.1531G>A	c.(1531-1533)Gag>Aag	p.E511K	FCHSD2_ENST00000458644.2_Missense_Mutation_p.E351K|ATG16L2_ENST00000534905.1_3'UTR|FCHSD2_ENST00000409853.1_Missense_Mutation_p.E431K|FCHSD2_ENST00000409418.4_Missense_Mutation_p.E487K|FCHSD2_ENST00000311172.7_Missense_Mutation_p.E431K			O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	487	SH3 1.						protein binding			endometrium(2)|large_intestine(11)|lung(5)|ovary(2)|prostate(1)|skin(1)	22			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			ATGGTCAACTCATCTGGTTGA	0.418000													18	28					0	0	1	0	0
IL1R1	3554	broad.mit.edu	37	2	102792115	102792115	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:102792115T>C	ENST00000424272.1	+	11	1554	c.1313T>C	c.(1312-1314)gTa>gCa	p.V438A	AC007271.3_ENST00000428188.1_RNA|IL1R1_ENST00000410023.1_Intron|IL1R1_ENST00000409329.1_Missense_Mutation_p.V438A|IL1R1_ENST00000409929.1_Intron|IL1R1_ENST00000409589.1_Intron|IL1R1_ENST00000409288.1_Missense_Mutation_p.V438A|IL1R1_ENST00000233946.3_Intron			P14778	IL1R1_HUMAN	interleukin 1 receptor, type I	0	TIR.				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|prostate(2)|skin(3)	19					Anakinra(DB00026)	GGTATGTGTGTAATGGAACAG	0.368000													32	135					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92663751	92663751	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:92663751C>A	ENST00000318445.6	+	5	1280	c.1066C>A	c.(1066-1068)Ctg>Atg	p.L356M	SLCO3A1_ENST00000555549.1_3'UTR|SLCO3A1_ENST00000424469.2_Missense_Mutation_p.L356M	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	356					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			CTGCATCATCCTGGCCGCCTG	0.567000													97	118					3.45148e-53	3.88244e-53	1	1	0
C1orf226	400793	broad.mit.edu	37	1	162351690	162351690	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:162351690G>T	ENST00000426197.2	+	2	201	c.128G>T	c.(127-129)gGc>gTc	p.G43V	C1orf226_ENST00000458626.2_5'UTR|RP11-565P22.6_ENST00000431696.1_Missense_Mutation_p.109_109insV	NM_001135240.1	NP_001128712.1	A1L170	CA226_HUMAN	chromosome 1 open reading frame 226	0										central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12						GTTGACCACGGCATGTTTGAG	0.557000													6	17					0.00307968	0.00311927	1	1	0
SCAF1	58506	broad.mit.edu	37	19	50154650	50154650	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50154650C>T	ENST00000360565.3	+	7	1128	c.1004C>T	c.(1003-1005)aCg>aTg	p.T335M		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	335					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GCCCCTGGAACGCCGCCCCAG	0.701000													3	8					0	0	1	0	0
CTBS	1486	broad.mit.edu	37	1	85031599	85031599	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:85031599A>T	ENST00000370630.4	-	4	670	c.622T>A	c.(622-624)Tct>Act	p.S208T	CTBS_ENST00000477677.1_5'UTR	NM_004388.2	NP_004379.1	Q01459	DIAC_HUMAN	chitobiase, di-N-acetyl-	208						lysosome	cation binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)	9				all cancers(265;0.00727)|Epithelial(280;0.0192)|OV - Ovarian serous cystadenocarcinoma(397;0.166)		TCATCATAAGACATCACAAAG	0.388000													10	45					0	0	1	0	0
PMEL	6490	broad.mit.edu	37	12	56349134	56349134	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56349134C>A	ENST00000548747.1	-	10	2436	c.1774G>T	c.(1774-1776)Ggc>Tgc	p.G592C	PMEL_ENST00000548493.1_Missense_Mutation_p.G592C|PMEL_ENST00000360714.4_Missense_Mutation_p.G599C|PMEL_ENST00000449260.2_Missense_Mutation_p.G599C|PMEL_ENST00000536427.1_Missense_Mutation_p.G557C|PMEL_ENST00000550464.1_Missense_Mutation_p.G506C|PMEL_ENST00000552882.1_Missense_Mutation_p.G592C|PMEL_ENST00000539511.1_Missense_Mutation_p.G506C|PMEL_ENST00000550447.1_Missense_Mutation_p.G221C			P40967	PMEL_HUMAN	premelanosome protein	592				G -> GG (in Ref. 2; AA sequence).	melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TGCCCAAGGCCTGCTTCTTGA	0.537000													18	69					1.67942e-08	1.77343e-08	1	1	0
KLC1	3831	broad.mit.edu	37	14	104139525	104139525	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:104139525G>A	ENST00000389744.4	+	8	1430		c.e8+1		KLC1_ENST00000555836.1_Splice_Site|KLC1_ENST00000347839.6_Splice_Site|KLC1_ENST00000246489.7_Splice_Site|KLC1_ENST00000557575.1_Splice_Site|RP11-73M18.2_ENST00000472726.2_Splice_Site|KLC1_ENST00000557450.1_Splice_Site|KLC1_ENST00000380038.3_Splice_Site|KLC1_ENST00000445352.4_Splice_Site|KLC1_ENST00000554280.1_Splice_Site|KLC1_ENST00000348520.6_Splice_Site|KLC1_ENST00000452929.2_Splice_Site|KLC1_ENST00000553286.1_Splice_Site|KLC1_ENST00000334553.6_Splice_Site			Q07866	KLC1_HUMAN	kinesin light chain 1						blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding		KLC1/ALK(2)	NS(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	12		Melanoma(154;0.155)|all_epithelial(191;0.19)				AAATAACCTGGTGTGTTGACT	0.433000													11	13					0	0	1	0	0
DHH	50846	broad.mit.edu	37	12	49483682	49483682	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49483682G>A	ENST00000266991.2	-	3	1457	c.1151C>T	c.(1150-1152)tCt>tTt	p.S384F		NM_021044.2	NP_066382.1	O43323	DHH_HUMAN	desert hedgehog	384					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			breast(1)|large_intestine(3)|lung(4)	8						GAGGAGCCGAGAGTACCAATG	0.662000													3	0					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90348601	90348601	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:90348601C>T	ENST00000300060.6	-	3	1021	c.708G>A	c.(706-708)acG>acA	p.T236T		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	236	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GGTGGATAAGCGTGATGTTGA	0.642000													13	25					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136078015	136078015	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:136078015G>A	ENST00000383202.2	-	27	3167	c.2911C>T	c.(2911-2913)Cga>Tga	p.R971*	STAG1_ENST00000236698.5_Nonsense_Mutation_p.R971*|STAG1_ENST00000536929.1_Nonsense_Mutation_p.R555*|STAG1_ENST00000434713.2_Nonsense_Mutation_p.R711*	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	971					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						ACTGCTTCTCGTGTCTTAATC	0.413000													28	30					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904632	55904632	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55904632G>T	ENST00000301529.1	-	1	562	c.563C>A	c.(562-564)tCt>tAt	p.S188Y		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	188					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					ATCAGAGCAAGATAATGCTAA	0.308000													21	42					1.50039e-11	1.61536e-11	1	1	0
SCN1A	6323	broad.mit.edu	37	2	166848823	166848823	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166848823C>A	ENST00000423058.2	-	26	4979	c.4962G>T	c.(4960-4962)aaG>aaT	p.K1654N	SCN1A_ENST00000375405.3_Missense_Mutation_p.K1643N|AC010127.3_ENST00000597623.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.K1654N|SCN1A_ENST00000409050.1_Missense_Mutation_p.K1626N	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1654						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGCGGATCCCCTTTGCTCCTT	0.498000													33	51					2.80507e-11	3.01652e-11	1	1	0
TMEM39B	55116	broad.mit.edu	37	1	32568174	32568174	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32568174A>G	ENST00000336294.5	+	9	1525	c.1379A>G	c.(1378-1380)tAc>tGc	p.Y460C	TMEM39B_ENST00000373634.4_Missense_Mutation_p.Y261C|TMEM39B_ENST00000487305.1_3'UTR	NM_018056.2	NP_060526.2	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	460						integral to membrane				endometrium(2)|kidney(1)|lung(5)|ovary(1)|prostate(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TTCAGCAACTACTATGCCTTC	0.552000													24	40					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54439343	54439343	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:54439343G>A	ENST00000334206.5	-	4	660	c.484C>T	c.(484-486)Cag>Tag	p.Q162*	CDC20B_ENST00000296733.1_Nonsense_Mutation_p.Q162*|CDC20B_ENST00000322374.6_Nonsense_Mutation_p.Q162*|CDC20B_ENST00000381375.2_Nonsense_Mutation_p.Q162*|CDC20B_ENST00000331730.3_Nonsense_Mutation_p.Q141*			Q86Y33	CD20B_HUMAN	cell division cycle 20B	162										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			TTACCTACCTGCCCTTTTGAG	0.413000													10	44					0	0	1	0	0
EIF3F	8665	broad.mit.edu	37	11	8017564	8017564	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:8017564C>A	ENST00000533626.1	+	10	1695	c.1069C>A	c.(1069-1071)Ctg>Atg	p.L357M	EIF3F_ENST00000537635.1_Missense_Mutation_p.L372M|EIF3F_ENST00000449102.2_Missense_Mutation_p.L208M|EIF3F_ENST00000309828.4_Missense_Mutation_p.L357M			O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3, subunit F	357						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)	13				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACTTGTAAACCTGTGAATGGA	0.453000													42	63					2.54354e-34	2.85517e-34	1	1	0
FILIP1L	11259	broad.mit.edu	37	3	99649852	99649852	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:99649852C>A	ENST00000331335.5	-	2	483	c.13G>T	c.(13-15)Ggc>Tgc	p.G5C	FILIP1L_ENST00000354552.3_Missense_Mutation_p.G5C|CMSS1_ENST00000421999.2_Intron|FILIP1L_ENST00000398326.2_Missense_Mutation_p.G5C|CMSS1_ENST00000496116.1_Intron	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	5						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						GTATCACTGCCTCTGGAACGC	0.403000													20	42					1.90627e-21	2.11755e-21	1	1	0
PPAPDC3	84814	broad.mit.edu	37	9	134165620	134165620	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:134165620G>A	ENST00000372264.3	+	1	540	c.236G>A	c.(235-237)gGc>gAc	p.G79D	PPAPDC3_ENST00000372261.1_Missense_Mutation_p.G79D	NM_032728.3	NP_116117.3	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain containing 3	79	interaction with MTOR (By similarity).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)		TCCTTCAAGGGCATCGCCTTC	0.662000													17	66					0	0	1	0	0
COX5B	1329	broad.mit.edu	37	2	98264505	98264505	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:98264505C>T	ENST00000258424.2	+	4	371	c.324C>T	c.(322-324)ggC>ggT	p.G108G	COX5B_ENST00000464949.1_3'UTR	NM_001862.2	NP_001853.2	P10606	COX5B_HUMAN	cytochrome c oxidase subunit Vb	108					respiratory electron transport chain|respiratory gaseous exchange	mitochondrial inner membrane	cytochrome-c oxidase activity|metal ion binding			endometrium(1)|lung(1)|urinary_tract(1)	3						TGCACAAAGGCGAGGCCCAGC	0.517000													4	13					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126708434	126708434	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:126708434A>G	ENST00000251772.4	+	1	998	c.929A>G	c.(928-930)gAc>gGc	p.D310G	PLXNA1_ENST00000393409.2_Missense_Mutation_p.D333G			Q9UIW2	PLXA1_HUMAN	plexin A1	333	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CTGGCTGAGGACGAGGACGTG	0.657000													37	42					0	0	1	0	0
RPUSD3	285367	broad.mit.edu	37	3	9879810	9879810	+	Missense_Mutation	SNP	G	G	A	rs115670492	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9879810G>A	ENST00000383820.5	-	9	947	c.946C>T	c.(946-948)Cgg>Tgg	p.R316W	TTLL3_ENST00000455274.1_Intron|RPUSD3_ENST00000433535.2_Missense_Mutation_p.R301W|RPUSD3_ENST00000424438.1_3'UTR	NM_173659.3	NP_775930.2	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	316					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(2)|endometrium(3)|lung(2)	7	Medulloblastoma(99;0.227)					AGAAGGAGCCGATGTAGGTGG	0.662000													15	17					0	0	1	0	0
SMCR7	0	broad.mit.edu	37	17	18167674	18167674	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18167674C>T	ENST00000323019.4	+	4	1172	c.961C>T	c.(961-963)Ccc>Tcc	p.P321S	SMCR7_ENST00000395706.2_Missense_Mutation_p.P332S|SMCR7_ENST00000395704.4_3'UTR	NM_001144900.1|NM_139162.3	NP_001138372.1|NP_631901.2	Q96C03	SMCR7_HUMAN		321						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(4)	9	all_neural(463;0.228)					CTTGGCCTGGCCCCTGGAGGG	0.677000													14	78					0	0	1	0	0
WBP11P1	0	broad.mit.edu	37	18	30093505	30093505	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:30093505G>A	ENST00000567636.1	+	0	1880					NR_003558.1																						GAAAGCCACAGCAACCGTCAC	0.498000													53	113					0	0	1	0	0
SARS	6301	broad.mit.edu	37	1	109780463	109780463	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109780463G>A	ENST00000369923.4	+	12	1575	c.1564G>A	c.(1564-1566)Gtc>Atc	p.V522I	SARS_ENST00000468588.1_3'UTR|SARS_ENST00000234677.2_Missense_Mutation_p.V500I			P49591	SYSC_HUMAN	seryl-tRNA synthetase	500					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	17		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	AGCAAGAGACGTCACCCTAGA	0.502000													14	12					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13936507	13936507	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13936507G>A	ENST00000254323.2	+	11	2197	c.2008G>A	c.(2008-2010)Gca>Aca	p.A670T	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.A504T	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	670							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			GCTGGGCATCGCACTGGAGCT	0.687000													11	14					0	0	1	0	0
POU2F2	5452	broad.mit.edu	37	19	42596302	42596302	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42596302G>A	ENST00000389341.5	-	13	1337	c.1271C>T	c.(1270-1272)cCg>cTg	p.P424L	POU2F2_ENST00000529952.1_Missense_Mutation_p.P440L|POU2F2_ENST00000560398.1_Missense_Mutation_p.P446L|POU2F2_ENST00000342301.4_Missense_Mutation_p.P440L|POU2F2_ENST00000533720.1_Missense_Mutation_p.P424L|POU2F2_ENST00000560558.1_Missense_Mutation_p.P385L|POU2F2_ENST00000529067.1_Intron|POU2F2_ENST00000526816.2_Missense_Mutation_p.P440L	NM_001207025.2|NM_001247994.1|NM_002698.4	NP_001193954.1|NP_001234923.1|NP_002689.1	P09086	PO2F2_HUMAN	POU class 2 homeobox 2	440	Gly-rich.				humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(69;0.059)				GGTGGTGGCCGGGGGTGGGGG	0.706000													3	3					0	0	1	0	0
SLC39A8	64116	broad.mit.edu	37	4	103188797	103188797	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:103188797G>A	ENST00000424970.2	-	8	1398	c.1083C>T	c.(1081-1083)agC>agT	p.S361S	SLC39A8_ENST00000356736.4_Silent_p.S361S|SLC39A8_ENST00000394833.2_Silent_p.S361S	NM_001135147.1	NP_001128619.1	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter), member 8	361						integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity			large_intestine(1)|lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		CTTGTCGAGTGCTCATCCCTG	0.378000													7	42					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101705100	101705100	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:101705100C>T	ENST00000305352.6	+	2	935	c.560C>T	c.(559-561)gCg>gTg	p.A187V		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	187					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						TGCATCAGTGCGCTGTCCAGC	0.572000											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	39					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100160238	100160238	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:100160238G>T	ENST00000395996.1	+	14	2124	c.2013_splice	c.e14+1	p.K671_splice	VPS13B_ENST00000358544.2_Splice_Site_p.K671_splice|VPS13B_ENST00000357162.2_Splice_Site_p.K671_splice|VPS13B_ENST00000355155.1_Splice_Site_p.K671_splice			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	671					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGGGAGAAAAGGTATATTTTG	0.358000													20	50					1.22574e-08	1.29596e-08	1	1	0
SIAH3	283514	broad.mit.edu	37	13	46357673	46357673	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:46357673G>A	ENST00000400405.2	-	2	761	c.655C>T	c.(655-657)Cgg>Tgg	p.R219W		NM_198849.2	NP_942146.2	Q8IW03	SIAH3_HUMAN	siah E3 ubiquitin protein ligase family member 3	219					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			large_intestine(3)|lung(7)|ovary(1)|skin(1)	12						AGAACAGACCGGGGCGTGGCC	0.617000													9	15					0	0	1	0	0
TRIM39-RPP21	0	broad.mit.edu	37	6	30314256	30314256	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30314256C>T	ENST00000513556.1	+	9	1072	c.1072C>T	c.(1072-1074)Cgc>Tgc	p.R358C	RPP21_ENST00000466327.1_3'UTR|RPP21_ENST00000433076.2_Missense_Mutation_p.R105C|RPP21_ENST00000442966.2_Missense_Mutation_p.R97C|RPP21_ENST00000428040.2_Missense_Mutation_p.R120C|RPP21_ENST00000436442.2_Missense_Mutation_p.R97C	NM_001199119.1	NP_001186048.1	A6ZJ12	A6ZJ12_HUMAN		358						intracellular	zinc ion binding										AACATGCCAGCGCAGCCAACG	0.572000													15	15					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89804415	89804415	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:89804415C>T	ENST00000289816.5	+	11	1693	c.1381C>T	c.(1381-1383)Cgg>Tgg	p.R461W	ZNF276_ENST00000446326.2_Missense_Mutation_p.R322W|ZNF276_ENST00000443381.2_Missense_Mutation_p.R536W|FANCA_ENST00000389301.3_3'UTR|ZNF276_ENST00000568064.1_3'UTR	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	536					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GTGCAGGCAGCGGGCATCCCT	0.597000													10	23					0	0	1	0	0
CDC45	8318	broad.mit.edu	37	22	19504132	19504132	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19504132G>A	ENST00000407835.1	+	17	1779	c.1523G>A	c.(1522-1524)gGc>gAc	p.G508D	CDC45_ENST00000437685.2_Missense_Mutation_p.G540D|CDC45_ENST00000263201.1_Missense_Mutation_p.G508D|CDC45_ENST00000404724.3_Missense_Mutation_p.G462D			O75419	CDC45_HUMAN	cell division cycle 45	508					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	19						ACCGTGGTGGGCATCCCCCCA	0.607000													14	18					0	0	1	0	0
GOT1	2805	broad.mit.edu	37	10	101162417	101162417	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:101162417C>T	ENST00000370508.5	-	8	1049	c.1022G>A	c.(1021-1023)cGa>cAa	p.R341Q	GOT1_ENST00000543866.1_Missense_Mutation_p.R320Q	NM_002079.2	NP_002070.1	P17174	AATC_HUMAN	glutamic-oxaloacetic transaminase 1, soluble	341					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)	16		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GGCTTCTAGTCGTGCCCTGAG	0.507000													27	33					0	0	1	0	0
MSTO1	55154	broad.mit.edu	37	1	155582956	155582956	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155582956G>A	ENST00000245564.2	+	11	1239	c.1215G>A	c.(1213-1215)gaG>gaA	p.E405E	MSTO1_ENST00000452804.2_Intron|MSTO1_ENST00000483734.1_3'UTR|MSTO1_ENST00000538143.1_Intron|MSTO1_ENST00000368341.4_Silent_p.E370E	NM_001256532.1|NM_001256533.1|NM_018116.3	NP_001243461.1|NP_001243462.1|NP_060586.2	Q9BUK6	MSTO1_HUMAN	misato 1, mitochondrial distribution and morphology regulator	405					mitochondrion distribution|protein polymerization	mitochondrial outer membrane|protein complex				breast(2)|endometrium(1)|lung(3)|skin(1)	7	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)					CATGTGGGGAGCCTTCTGGAA	0.567000													26	39					0	0	1	0	0
RUFY4	285180	broad.mit.edu	37	2	218940239	218940239	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:218940239G>A	ENST00000374155.3	+	8	1494	c.1084G>A	c.(1084-1086)Gtc>Atc	p.V362I	RUFY4_ENST00000463872.1_3'UTR|RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000344321.7_Missense_Mutation_p.V342I			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	342							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GTGGAGTCACGTCCAGAGGCT	0.617000													7	7					0	0	1	0	0
HLTF	6596	broad.mit.edu	37	3	148777552	148777552	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:148777552G>C	ENST00000310053.5	-	13	1521	c.1328C>G	c.(1327-1329)gCa>gGa	p.A443G	HLTF_ENST00000494055.1_Missense_Mutation_p.A443G|HLTF_ENST00000392912.2_Missense_Mutation_p.A443G|HLTF_ENST00000465259.1_Missense_Mutation_p.A442G	NM_003071.3|NM_139048.2	NP_003062.2|NP_620636.1	Q14527	HLTF_HUMAN	helicase-like transcription factor	443	Helicase ATP-binding.				chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TGAAGTTAATGCACATGCAAA	0.303000													20	39					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107602081	107602081	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:107602081C>T	ENST00000393561.1	-	14	2154	c.1970G>A	c.(1969-1971)cGa>cAa	p.R657Q	LAMB1_ENST00000222399.6_Missense_Mutation_p.R633Q|LAMB1_ENST00000393560.1_Missense_Mutation_p.R633Q			P07942	LAMB1_HUMAN	laminin, beta 1	633	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTTCCAGGTCGCTGCACTGT	0.478000													22	35					0	0	1	0	0
MOB3A	126308	broad.mit.edu	37	19	2078368	2078368	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2078368G>A	ENST00000357066.3	-	3	571	c.192C>T	c.(190-192)caC>caT	p.H64H	MOB3A_ENST00000592280.1_Silent_p.H64H|MOB3A_ENST00000592143.1_Intron	NM_130807.2	NP_570719.1	Q96BX8	MOL2A_HUMAN	MOB kinase activator 3A	64						intracellular	metal ion binding										AGTCCACCACGTGAACAGCCA	0.657000													19	30					0	0	1	0	0
TRAF2	7186	broad.mit.edu	37	9	139820270	139820270	+	Missense_Mutation	SNP	G	G	A	rs148765924		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139820270G>A	ENST00000359662.3	+	11	1624	c.1579G>A	c.(1579-1581)Gtc>Atc	p.V527I	TRAF2_ENST00000536468.1_Missense_Mutation_p.V475I|TRAF2_ENST00000247668.2_Missense_Mutation_p.V475I			Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	475					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		CTTCTGCCCCGTCTCCAAGAT	0.567000													17	27					0	0	1	0	0
SSTR1	0	broad.mit.edu	37	14	38679094	38679094	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:38679094G>A	ENST00000267377.2	+	3	1117	c.500G>A	c.(499-501)cGc>cAc	p.R167H		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	167					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	AAGGCGGCCCGCTACCGCCGG	0.642000													25	37					0	0	1	0	0
RMND1	55005	broad.mit.edu	37	6	151766709	151766709	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:151766709G>A	ENST00000367303.4	-	2	360	c.238C>T	c.(238-240)Ctg>Ttg	p.L80L	RMND1_ENST00000491268.1_5'UTR	NM_017909.2	NP_060379.2	Q9NWS8	RMND1_HUMAN	required for meiotic nuclear division 1 homolog (S. cerevisiae)	80										central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.146)	OV - Ovarian serous cystadenocarcinoma(155;6.8e-11)		AATGGAGACAGCATGCTGGTA	0.423000													13	129					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98660391	98660391	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:98660391C>T	ENST00000261574.5	+	18	2029	c.1849C>T	c.(1849-1851)Cct>Tct	p.P617S	IPO5_ENST00000539640.1_Missense_Mutation_p.P474S|IPO5_ENST00000490680.1_Missense_Mutation_p.P599S	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	599					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						AGATGATGATCCTCAGGTAAG	0.383000													14	26					0	0	1	0	0
GALE	2582	broad.mit.edu	37	1	24122731	24122731	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24122731G>A	ENST00000374497.3	-	11	989	c.898C>T	c.(898-900)Cgg>Tgg	p.R300W		NM_000403.3|NM_001008216.1|NM_001127621.1	NP_000394.2|NP_001008217.1|NP_001121093.1	Q14376	GALE_HUMAN	UDP-galactose-4-epimerase	300					galactose catabolic process	cytosol	coenzyme binding|protein homodimerization activity|UDP-glucose 4-epimerase activity			endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		TCACCTTCCCGCCGTGCCACC	0.617000													18	21					0	0	1	0	0
PFN2	5217	broad.mit.edu	37	3	149686268	149686268	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:149686268C>T	ENST00000239940.7	-	2	454	c.202G>A	c.(202-204)Gcg>Acg	p.A68T	PFN2_ENST00000489155.1_Missense_Mutation_p.A19T|PFN2_ENST00000494827.1_Missense_Mutation_p.A19T|PFN2_ENST00000497148.1_Missense_Mutation_p.A19T|PFN2_ENST00000481275.1_Missense_Mutation_p.A19T|PFN2_ENST00000461930.1_3'UTR|PFN2_ENST00000423691.2_Missense_Mutation_p.A68T|PFN2_ENST00000490975.1_Missense_Mutation_p.A68T|PFN2_ENST00000475518.1_Missense_Mutation_p.A19T|PFN2_ENST00000461868.1_Missense_Mutation_p.A68T|PFN2_ENST00000481767.1_Missense_Mutation_p.A19T|PFN2_ENST00000498307.1_Missense_Mutation_p.A19T|PFN2_ENST00000452853.2_Missense_Mutation_p.A68T			P35080	PROF2_HUMAN	profilin 2	68					actin cytoskeleton organization|regulation of actin polymerization or depolymerization	actin cytoskeleton|cytoplasm	actin binding|phosphatidylinositol-4,5-bisphosphate binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CATTTCTTCGCGCCAAGAGTC	0.438000													67	98					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30930565	30930565	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:30930565C>A	ENST00000597505.1	-	27	3845	c.3846G>T	c.(3844-3846)aaG>aaT	p.K1282N	DCDC1_ENST00000406071.2_Missense_Mutation_p.K17N|DCDC1_ENST00000339794.5_Missense_Mutation_p.K361N			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction			p.K361N(2)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					ATGTAATTTCCTTATCCAAGG	0.368000													24	33					9.04412e-07	9.43082e-07	1	1	0
IL17RD	54756	broad.mit.edu	37	3	57131715	57131715	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:57131715G>A	ENST00000296318.7	-	12	2104	c.2016C>T	c.(2014-2016)tcC>tcT	p.S672S	IL17RD_ENST00000320057.5_Silent_p.S528S|IL17RD_ENST00000463523.1_Silent_p.S528S|IL17RD_ENST00000427856.2_Silent_p.S648S	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	672						Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		GAGACAGCTCGGATGAGGGCA	0.627000													8	8					0	0	1	0	0
ATIC	471	broad.mit.edu	37	2	216211645	216211645	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:216211645T>C	ENST00000435675.1	+	13	1872	c.1481T>C	c.(1480-1482)gTg>gCg	p.V494A	ATIC_ENST00000236959.9_Missense_Mutation_p.V495A|ATIC_ENST00000540518.1_Missense_Mutation_p.V436A			P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	495					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	large_intestine(2)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	8		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	GATCAATATGTGACTGGAACC	0.418000			T	ALK	ALCL								12	17					0	0	1	0	0
BBS12	166379	broad.mit.edu	37	4	123664604	123664604	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:123664604C>T	ENST00000542236.1	+	3	1938	c.1557C>T	c.(1555-1557)ttC>ttT	p.F519F	BBS12_ENST00000314218.3_Silent_p.F519F	NM_001178007.1	NP_001171478.1	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	519					cellular protein metabolic process	cilium	ATP binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|prostate(4)	21						AAGATAGGTTCTGGACATGTG	0.393000									Bardet-Biedl syndrome				20	62					0	0	1	0	0
PTGER4	5734	broad.mit.edu	37	5	40691949	40691949	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:40691949G>A	ENST00000302472.3	+	3	1960	c.936G>A	c.(934-936)ttG>ttA	p.L312L		NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	312					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						ATCCAGATTTGCAGGCCATCC	0.428000													5	101					0	0	1	0	0
MEF2D	4209	broad.mit.edu	37	1	156444988	156444988	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156444988C>T	ENST00000348159.4	-	9	1398	c.918G>A	c.(916-918)tcG>tcA	p.S306S	MEF2D_ENST00000360595.3_Silent_p.S299S|MEF2D_ENST00000340875.5_Silent_p.S305S|MEF2D_ENST00000353795.3_Silent_p.S260S|MEF2D_ENST00000368240.2_Silent_p.S299S|MEF2D_ENST00000464356.1_Intron	NM_005920.2	NP_005911.1	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	306					apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	15	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGTGGTGAGCGAATGAGTAG	0.567000													14	27					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101828970	101828970	+	Missense_Mutation	SNP	A	A	G	rs146349473		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:101828970A>G	ENST00000263468.8	+	5	848	c.578A>G	c.(577-579)aAa>aGa	p.K193R	KIAA1377_ENST00000537689.1_5'UTR	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	193							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		CTCTTATCCAAAATCAATTGT	0.383000													90	140					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243328145	243328145	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:243328145A>G	ENST00000366542.1	-	13	3168	c.3117T>C	c.(3115-3117)atT>atC	p.I1039I	CEP170_ENST00000366544.1_Silent_p.I941I|RP11-261C10.4_ENST00000422938.1_RNA|RP11-261C10.4_ENST00000437499.1_RNA|CEP170_ENST00000366543.1_Silent_p.I941I	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	1039	Targeting to microtubules.					centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CAGATGACATAATATCAGAGA	0.418000													14	34					0	0	1	0	0
PPP1R12C	54776	broad.mit.edu	37	19	55623925	55623925	+	Missense_Mutation	SNP	C	C	T	rs139818172		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55623925C>T	ENST00000263433.3	-	3	496	c.481G>A	c.(481-483)Gcc>Acc	p.A161T	PPP1R12C_ENST00000435544.2_Missense_Mutation_p.A87T|PPP1R12C_ENST00000376393.2_Missense_Mutation_p.A161T	NM_001271618.1|NM_017607.2	NP_001258547.1|NP_060077.1	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	161						cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	22			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		TTGACGGCGGCGATGTTGGCC	0.726000													21	12					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34209135	34209135	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:34209135T>C	ENST00000373381.4	-	14	2095	c.1919A>G	c.(1918-1920)aAc>aGc	p.N640S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	600	CUB 4.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGGAGGTGGTTGCCATAGTC	0.567000													19	29					0	0	1	0	0
APLP2	334	broad.mit.edu	37	11	129993594	129993594	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:129993594G>A	ENST00000263574.5	+	7	1082	c.1010G>A	c.(1009-1011)cGc>cAc	p.R337H	APLP2_ENST00000528499.1_Intron|APLP2_ENST00000345598.5_Intron|APLP2_ENST00000539648.1_Intron|APLP2_ENST00000338167.5_Missense_Mutation_p.R337H|APLP2_ENST00000278756.7_Missense_Mutation_p.R347H|APLP2_ENST00000543137.1_Missense_Mutation_p.R244H	NM_001642.2	NP_001633.1	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	337	BPTI/Kunitz inhibitor.				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		AAGTGCGTGCGCTTTATATAT	0.552000													38	51					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125801957	125801957	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:125801957A>G	ENST00000346248.5	-	4	1535	c.893T>C	c.(892-894)gTc>gCc	p.V298A	CHST15_ENST00000421115.1_Missense_Mutation_p.V298A|CHST15_ENST00000435907.1_Missense_Mutation_p.V298A	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	298					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						TCTTAGGCGGACGATTCCTAT	0.547000													17	13					0	0	1	0	0
SRMS	6725	broad.mit.edu	37	20	62173545	62173545	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:62173545C>T	ENST00000217188.1	-	5	957	c.917G>A	c.(916-918)cGc>cAc	p.R306H		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	306	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GTTCCCCTTGCGCATGAGTTC	0.682000													6	22					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167833895	167833895	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:167833895C>A	ENST00000357154.3	-	6	497		c.e6-1		SPOCK3_ENST00000506886.1_Splice_Site|SPOCK3_ENST00000421836.2_Splice_Site|SPOCK3_ENST00000502330.1_Splice_Site|SPOCK3_ENST00000507137.1_Splice_Site|SPOCK3_ENST00000510741.1_Splice_Site|SPOCK3_ENST00000504953.1_Splice_Site|SPOCK3_ENST00000541354.1_Splice_Site|SPOCK3_ENST00000534949.1_Splice_Site|SPOCK3_ENST00000535728.1_Splice_Site|SPOCK3_ENST00000511531.1_Splice_Site|SPOCK3_ENST00000511269.1_Splice_Site|SPOCK3_ENST00000357545.4_Splice_Site|SPOCK3_ENST00000512648.1_Splice_Site|SPOCK3_ENST00000541637.1_Intron|SPOCK3_ENST00000512681.1_Intron	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3						signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		TTCTTTCATCCTGTTAAAAAA	0.408000													12	24					3.07112e-06	3.18879e-06	1	1	0
NYAP2	57624	broad.mit.edu	37	2	226446657	226446657	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:226446657C>T	ENST00000272907.6	+	4	937	c.523_splice	c.e4-1	p.A175_splice	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	175																	CTTCTTTTAGCGTCAGCTAAA	0.403000													33	53					0	0	1	0	0
MARCH3	115123	broad.mit.edu	37	5	126250790	126250790	+	Silent	SNP	G	G	A	rs140296174		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:126250790G>A	ENST00000308660.5	-	3	739	c.225C>T	c.(223-225)caC>caT	p.H75H	MARCH3_ENST00000515241.1_Silent_p.H75H|MARCH3_ENST00000502289.1_5'UTR	NM_178450.3	NP_848545.1	Q86UD3	MARH3_HUMAN	membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase	75					endocytosis	cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosome	ligase activity|zinc ion binding			large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.074)|OV - Ovarian serous cystadenocarcinoma(64;0.0793)		TGCTGCCCTCGTGGCAGATCC	0.592000													14	20					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63174354	63174354	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:63174354C>T	ENST00000322893.7	-	11	3107	c.2839G>A	c.(2839-2841)Gta>Ata	p.V947I	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	947	CAD (involved in subunit assembly) (By similarity).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity	p.V947L(1)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GCCTGGGGTACGCTTTTTTCC	0.473000													42	88					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84492742	84492742	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:84492742G>T	ENST00000416219.2	+	22	2253	c.2164G>T	c.(2164-2166)Ggc>Tgc	p.G722C	ATP2C2_ENST00000420010.2_3'UTR|ATP2C2_ENST00000262429.4_Missense_Mutation_p.G722C			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	722					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						AGTGGAGGAAGGCAAGGGTAT	0.542000													26	40					2.48779e-11	2.67617e-11	1	1	0
GBX2	2637	broad.mit.edu	37	2	237074856	237074856	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:237074856G>A	ENST00000306318.4	-	2	1145	c.748C>T	c.(748-750)Cgg>Tgg	p.R250W	GBX2_ENST00000465889.1_5'UTR|GBX2_ENST00000551105.1_3'UTR	NM_001485.2	NP_001476.2	P52951	GBX2_HUMAN	gastrulation brain homeobox 2	250	Poly-Arg.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		GCAGTCCGCCGCCGCCGGTTC	0.677000													16	27					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8718444	8718444	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:8718444C>T	ENST00000306329.11	+	2	1076	c.1076C>T	c.(1075-1077)gCt>gTt	p.A359V	SOGA2_ENST00000400050.3_5'UTR|SOGA2_ENST00000359865.3_5'UTR|SOGA2_ENST00000306285.7_5'UTR|SOGA2_ENST00000517570.1_5'UTR			Q9Y4B5	CC165_HUMAN	SOGA family member 2	350																	GAACTCCGTGCTGAGATGGAA	0.448000													10	15					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48646294	48646294	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48646294G>A	ENST00000352832.5	+	2	678	c.306G>A	c.(304-306)cgG>cgA	p.R102R	CACNA1G_ENST00000513689.2_Silent_p.R102R|CACNA1G_ENST00000507510.2_Silent_p.R102R|CACNA1G_ENST00000512389.1_Silent_p.R102R|CACNA1G_ENST00000514079.1_Silent_p.R102R|CACNA1G_ENST00000510115.1_Silent_p.R102R|CACNA1G_ENST00000510366.1_Silent_p.R102R|CACNA1G_ENST00000515411.1_Silent_p.R102R|CACNA1G_ENST00000515765.1_Silent_p.R102R|CACNA1G_ENST00000507896.1_Silent_p.R102R|CACNA1G_ENST00000503485.1_Silent_p.R102R|CACNA1G_ENST00000358244.5_Silent_p.R102R|CACNA1G_ENST00000513964.1_Silent_p.R102R|CACNA1G_ENST00000505165.1_Silent_p.R102R|CACNA1G_ENST00000515165.1_Silent_p.R102R|CACNA1G_ENST00000442258.2_Silent_p.R102R|CACNA1G_ENST00000360761.4_Silent_p.R102R|CACNA1G_ENST00000502264.1_Silent_p.R102R|CACNA1G_ENST00000514181.1_Silent_p.R102R|CACNA1G_ENST00000507336.1_Silent_p.R102R|CACNA1G_ENST00000507609.1_Silent_p.R102R|CACNA1G_ENST00000359106.5_Silent_p.R102R|CACNA1G_ENST00000514717.1_Silent_p.R102R|CACNA1G_ENST00000429973.2_Silent_p.R102R|CACNA1G_ENST00000354983.4_Silent_p.R102R|CACNA1G_ENST00000416767.4_Silent_p.R102R	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	102					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCATGTTCCGGCCATGCGAGG	0.577000													19	29					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100087214	100087214	+	Missense_Mutation	SNP	G	G	A	rs137910126		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100087214G>A	ENST00000423930.1	+	4	2029	c.1870G>A	c.(1870-1872)Gcc>Acc	p.A624T	NYAP1_ENST00000300179.2_Missense_Mutation_p.A624T|NYAP1_ENST00000454988.1_Missense_Mutation_p.A567T			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	624																	GGAGGTGGGCGCCGCGACATT	0.632000													15	32					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190428735	190428735	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190428735C>T	ENST00000261024.2	-	7	1403	c.977G>A	c.(976-978)tGc>tAc	p.C326Y		NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	326			C -> Y (in iron overload).		anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			TGTGGTGATGCAGTCAAAGCC	0.498000													3	13					0	0	1	0	0
SUMF1	285362	broad.mit.edu	37	3	4452611	4452611	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:4452611C>T	ENST00000272902.5	-	7	927	c.892G>A	c.(892-894)Gca>Aca	p.A298T	SUMF1_ENST00000458465.2_Missense_Mutation_p.A166T|SUMF1_ENST00000534863.1_Missense_Mutation_p.A298T|SUMF1_ENST00000405420.2_Missense_Mutation_p.A298T|SUMF1_ENST00000383843.5_Missense_Mutation_p.A273T	NM_182760.3	NP_877437.2	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1	298						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(3)	13		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		CATTCCCATGCGTTCCCCACT	0.423000													36	60					0	0	1	0	0
ZNF775	285971	broad.mit.edu	37	7	150095097	150095097	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150095097G>A	ENST00000329630.5	+	3	1635	c.1528G>A	c.(1528-1530)Ggc>Agc	p.G510S		NM_173680.3	NP_775951.2	Q96BV0	ZN775_HUMAN	zinc finger protein 775	510					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(7)|skin(1)	11	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGCGGCCGCGGCTTCAGCCA	0.721000													4	5					0	0	1	0	0
MAX	4149	broad.mit.edu	37	14	65550920	65550920	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:65550920T>C	ENST00000246163.2	-	4	438	c.269A>G	c.(268-270)aAg>aGg	p.K90R	MAX_ENST00000358664.4_Intron|MAX_ENST00000358402.4_Intron|MAX_ENST00000284165.6_Intron|MAX_ENST00000555419.1_Intron|MAX_ENST00000555667.1_Intron|MAX_ENST00000556443.1_Intron|MAX_ENST00000341653.2_Intron|MAX_ENST00000557746.1_Intron|MAX_ENST00000557277.1_Intron|MAX_ENST00000556979.1_Intron|MAX_ENST00000555932.1_Intron|RP11-840I19.3_ENST00000556127.1_RNA	NM_145114.1	NP_660089.1	P61244	MAX_HUMAN	MYC associated factor X	0	Leucine-zipper.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		TTCTTTTTTCTTGTGCACTTG	0.388000													28	53					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144879390	144879390	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:144879390G>T	ENST00000369359.4	-	30	4506	c.4468C>A	c.(4468-4470)Cta>Ata	p.L1490I	PDE4DIP_ENST00000530740.1_Missense_Mutation_p.L1490I|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.L1354I|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.L1310I|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.L1354I|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1354					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCTTTCGTAGGACCAAGATG	0.502000			T	PDGFRB	MPD								77	288					1.88935e-48	2.1248e-48	1	1	0
VCAN	1462	broad.mit.edu	37	5	82789511	82789511	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:82789511G>A	ENST00000265077.3	+	4	1157	c.592G>A	c.(592-594)Gca>Aca	p.A198T	VCAN_ENST00000502527.2_Missense_Mutation_p.A198T|VCAN_ENST00000343200.5_Missense_Mutation_p.A198T|VCAN_ENST00000513984.1_Missense_Mutation_p.A198T|VCAN_ENST00000342785.4_Missense_Mutation_p.A198T|VCAN_ENST00000512590.2_Missense_Mutation_p.A150T	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	198	Link 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GCAGTGTGACGCAGGCTGGCT	0.502000													34	44					0	0	1	0	0
CDH1	999	broad.mit.edu	37	16	68847380	68847380	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:68847380C>T	ENST00000261769.5	+	9	1493	c.1302C>T	c.(1300-1302)ggC>ggT	p.G434G	CDH1_ENST00000562836.1_3'UTR|CDH1_ENST00000422392.2_Intron	NM_004360.3	NP_004351.1	P12830	CADH1_HUMAN	cadherin 1, type 1, E-cadherin (epithelial)	434	Cadherin 3.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.Y380_K440del(2)|p.?(1)		NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		ACAACGATGGCATTTTGAAAA	0.468000			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer				59	134					0	0	1	0	0
RP11-113D6.10	0	broad.mit.edu	37	11	18231401	18231401	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18231401C>A	ENST00000527059.1	+	1	647	c.187C>A	c.(187-189)Ctc>Atc	p.L63I	RP11-113D6.10_ENST00000534640.1_Missense_Mutation_p.L63I|RP11-113D6.10_ENST00000340135.3_Missense_Mutation_p.L63I																							TCAGAAGGTCCTCTTTCCACA	0.443000													16	42					6.49762e-13	7.04361e-13	1	1	0
DNAAF1	123872	broad.mit.edu	37	16	84188289	84188289	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:84188289C>T	ENST00000378553.5	+	4	584	c.460C>T	c.(460-462)Cgt>Tgt	p.R154C	DNAAF1_ENST00000334315.5_Missense_Mutation_p.R154C	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	154					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						AACTGAGTTGCGTTGCCTCTT	0.473000													19	29					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98744275	98744275	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:98744275C>A	ENST00000286067.2	+	1	3235	c.3128C>A	c.(3127-3129)cCt>cAt	p.P1043H		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	1043										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGCATCAACCCTCTGATGTCC	0.502000													32	56					1.56738e-10	1.67813e-10	1	1	0
EGFLAM	133584	broad.mit.edu	37	5	38407136	38407136	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:38407136G>A	ENST00000322350.5	+	8	1381	c.1035G>A	c.(1033-1035)atG>atA	p.M345I	EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000336740.6_Missense_Mutation_p.M111I|EGFLAM_ENST00000354891.3_Missense_Mutation_p.M345I	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	345	EGF-like 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TCTTTGACATGCCTTGTGATG	0.557000													15	21					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27849383	27849383	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27849383G>A	ENST00000261716.3	+	17	2513	c.1994G>A	c.(1993-1995)cGc>cAc	p.R665H	TAOK1_ENST00000536202.1_Intron	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	665					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			CTGGAGTTCCGCCACCTCAAC	0.433000													34	54					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91708964	91708964	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:91708964G>A	ENST00000359028.2	+	32	7778	c.7553G>A	c.(7552-7554)aGc>aAc	p.S2518N	AKAP9_ENST00000358100.2_Missense_Mutation_p.S2518N|AKAP9_ENST00000356239.3_Missense_Mutation_p.S2506N			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2518	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAACTTGAGAGCACTGTTAGT	0.348000			T	BRAF	papillary thyroid								10	27					0	0	1	0	0
SNHG14	0	broad.mit.edu	37	15	25326459	25326459	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:25326459C>T	ENST00000546682.1	+	0	71				SNORD116-15_ENST00000384445.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TCCATATATACATTCCTTGGA	0.463000													37	179					0	0	1	0	0
SREK1	140890	broad.mit.edu	37	5	65470839	65470839	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:65470839G>A	ENST00000334121.6	+	10	1709	c.1550G>A	c.(1549-1551)aGg>aAg	p.R517K	SREK1_ENST00000284041.3_3'UTR|SREK1_ENST00000380918.3_Missense_Mutation_p.R401K	NM_001077199.2|NM_001270492.1	NP_001070667.1|NP_001257421.1	Q8WXA9	SREK1_HUMAN	splicing regulatory glutamine/lysine-rich protein 1	401					mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)	9						ACCATAAAAAGGAAATCTTCT	0.378000													9	12					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42596331	42596331	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:42596331C>T	ENST00000264449.10	-	7	718	c.499G>A	c.(499-501)Gct>Act	p.A167T	ATP8A1_ENST00000381668.5_Intron	NM_001105529.1	NP_001098999.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	167					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	ACAGTGTCAGCAGGTATATAC	0.373000													26	60					0	0	1	0	0
PRKCI	5584	broad.mit.edu	37	3	169953062	169953062	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:169953062G>A	ENST00000295797.4	+	2	451	c.146G>A	c.(145-147)gGc>gAc	p.G49D		NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota	49	OPR.|Regulatory domain.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TCCTTTGAGGGCCTTTGCAAT	0.383000													22	34					0	0	1	0	0
OTUD4	54726	broad.mit.edu	37	4	146067543	146067543	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:146067543G>A	ENST00000454497.2	-	14	1240	c.1103C>T	c.(1102-1104)aCa>aTa	p.T368I	OTUD4_ENST00000447906.2_Missense_Mutation_p.T433I|OTUD4_ENST00000455611.2_5'UTR	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	432							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					TTCTCGACTTGTGTGATCAAA	0.333000													4	78					0	0	1	0	0
RPP40	10799	broad.mit.edu	37	6	5004148	5004148	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:5004148C>T	ENST00000380051.2	-	1	133	c.89G>A	c.(88-90)cGg>cAg	p.R30Q	RPP40_ENST00000319533.5_Missense_Mutation_p.R30Q	NM_006638.2	NP_006629.2	O75818	RPP40_HUMAN	ribonuclease P/MRP 40kDa subunit	30					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity			NS(1)|breast(1)|large_intestine(4)|lung(4)|ovary(1)|skin(2)|urinary_tract(1)	14	Ovarian(93;0.11)	all_hematologic(90;0.0895)				CACAAGATGCCGGTGGCGCGA	0.627000											OREG0017160	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	7					0	0	1	0	0
PANX2	56666	broad.mit.edu	37	22	50617461	50617461	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50617461G>A	ENST00000395842.2	+	3	1789	c.1789G>A	c.(1789-1791)Gcc>Acc	p.A597T	PANX2_ENST00000159647.5_Missense_Mutation_p.A597T	NM_052839.3	NP_443071.2	Q96RD6	PANX2_HUMAN	pannexin 2	597					protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)	7		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		ACCTCCCGCCGCCCCTGCTGT	0.692000													6	9					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24419488	24419488	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24419488C>T	ENST00000330966.7	-	10	1204	c.1042G>A	c.(1042-1044)Gtg>Atg	p.V348M	MYOM3_ENST00000329601.7_Missense_Mutation_p.V347M|MYOM3_ENST00000374434.3_Missense_Mutation_p.V347M|MYOM3_ENST00000475306.1_5'UTR			Q5VTT5	MYOM3_HUMAN	myomesin 3	347	Ig-like C2-type 2.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GGCGAGGGCACCCGGACCATG	0.642000													5	5					0	0	1	0	0
IL4I1	259307	broad.mit.edu	37	19	50397557	50397557	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50397557G>T	ENST00000595948.1	-	7	1221	c.601C>A	c.(601-603)Ccc>Acc	p.P201T	IL4I1_ENST00000391826.2_Missense_Mutation_p.P179T|IL4I1_ENST00000341114.3_Missense_Mutation_p.P201T	NM_001258018.1	NP_001244947.1	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1	179						lysosome	L-amino-acid oxidase activity			endometrium(3)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		ATGTCTTCGGGCGAGTGGCCC	0.637000													5	9					0.000602214	0.000612743	1	1	0
HNRNPH1	3187	broad.mit.edu	37	5	179046270	179046270	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:179046270C>A	ENST00000356731.5	-	4	2071	c.536_splice	c.e4+1	p.R179_splice	HNRNPH1_ENST00000510411.1_Splice_Site_p.R179_splice|HNRNPH1_ENST00000393432.4_Splice_Site_p.R179_splice|HNRNPH1_ENST00000329433.6_Splice_Site_p.R179_splice|HNRNPH1_ENST00000442819.2_Splice_Site_p.R179_splice			P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1 (H)	179	RRM 2.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|skin(1)	14						CCATCCCCACCTGTGCCCTAT	0.423000													6	192					3.59834e-05	3.7043e-05	1	1	0
GPR68	0	broad.mit.edu	37	14	91700554	91700554	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:91700554C>T	ENST00000535815.1	-	2	1181	c.841G>A	c.(841-843)Gcc>Acc	p.A281T	GPR68_ENST00000238699.3_Missense_Mutation_p.A291T|GPR68_ENST00000531499.2_Missense_Mutation_p.A281T	NM_001177676.1	NP_001171147.1	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	281					inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|lung(2)|skin(1)|urinary_tract(1)	8		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		ACGGGGTCGGCGACGCAGTTG	0.682000													4	4					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57087833	57087833	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57087833G>A	ENST00000532437.1	-	2	759	c.448C>T	c.(448-450)Cgc>Tgc	p.R150C	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.R150C			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	150	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				GAGGCTGGGCGGAAAGGGGCA	0.667000													20	44					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141036142	141036142	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:141036142G>A	ENST00000239440.4	-	27	3783	c.3718C>T	c.(3718-3720)Ctg>Ttg	p.L1240L	ARAP3_ENST00000508305.1_Silent_p.L1071L|ARAP3_ENST00000513878.1_Silent_p.L902L|ARAP3_ENST00000512390.1_5'UTR	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	1240	PH 3.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CGGCTTCCCAGCAAGCGAGGT	0.627000													4	5					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35923139	35923139	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:35923139C>T	ENST00000490799.1	-	17	2375	c.2022G>A	c.(2020-2022)ggG>ggA	p.G674G	SLC26A8_ENST00000394602.2_Silent_p.G569G|SLC26A8_ENST00000355574.2_Silent_p.G674G	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	674	Interaction with RACGAP1.|STAS.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						CATACTGTTGCCCTTGATTTT	0.483000													30	50					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	13356887	13356887	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:13356887C>T	ENST00000276297.4	-	2	1103	c.694G>A	c.(694-696)Gct>Act	p.A232T	DLC1_ENST00000316609.5_Missense_Mutation_p.A232T|DLC1_ENST00000511869.1_Missense_Mutation_p.A232T	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	232					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CGTTGCTGAGCAATTACAGCA	0.393000													62	115					0	0	1	0	0
AMIGO3	386724	broad.mit.edu	37	3	49755426	49755426	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49755426C>T	ENST00000535833.1	-	10	4923	c.1473G>A	c.(1471-1473)gaG>gaA	p.E491E	GMPPB_ENST00000480687.1_3'UTR|AMIGO3_ENST00000320431.7_Silent_p.E491E|RNF123_ENST00000327697.6_Intron|RNF123_ENST00000433785.1_Intron			Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	491					heterophilic cell-cell adhesion	integral to membrane				endometrium(1)|pancreas(1)|prostate(2)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGCTGGCGGACTCAGAGCCAG	0.662000													13	13					0	0	1	0	0
FIGLA	344018	broad.mit.edu	37	2	71012724	71012724	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:71012724T>C	ENST00000332372.6	-	3	436	c.432A>G	c.(430-432)tcA>tcG	p.S144S		NM_001004311.3	NP_001004311.2	Q6QHK4	FIGLA_HUMAN	folliculogenesis specific basic helix-loop-helix	144					multicellular organismal development|oocyte development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcription factor complex	DNA binding|transcription factor binding			endometrium(2)|lung(3)	5						AGGATGTATGTGATTCAGAAC	0.418000													33	196					0	0	1	0	0
NOA1	84273	broad.mit.edu	37	4	57832797	57832797	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:57832797T>C	ENST00000264230.4	-	5	2990	c.1753A>G	c.(1753-1755)Acg>Gcg	p.T585A		NM_032313.2	NP_115689.1	Q8NC60	CD014_HUMAN	nitric oxide associated 1	585							GTP binding										TGGAGTAACGTATGACCTGCA	0.478000													19	20					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55955612	55955612	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:55955612G>T	ENST00000373965.2	-	11	1530	c.1136C>A	c.(1135-1137)gCc>gAc	p.A379D	PCDH15_ENST00000373957.3_Missense_Mutation_p.A357D|PCDH15_ENST00000320301.6_Missense_Mutation_p.A379D|PCDH15_ENST00000395440.1_Missense_Mutation_p.A379D|PCDH15_ENST00000409834.1_5'UTR|PCDH15_ENST00000361849.3_Missense_Mutation_p.A379D|PCDH15_ENST00000437009.1_Missense_Mutation_p.A379D|PCDH15_ENST00000373955.1_Missense_Mutation_p.A379D|PCDH15_ENST00000414778.1_Missense_Mutation_p.A384D|PCDH15_ENST00000395433.1_Missense_Mutation_p.A357D|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.A379D|PCDH15_ENST00000395445.1_Missense_Mutation_p.A379D|PCDH15_ENST00000395446.1_Missense_Mutation_p.A379D|PCDH15_ENST00000395438.1_Missense_Mutation_p.A379D|PCDH15_ENST00000395432.2_Missense_Mutation_p.A342D	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	379	Cadherin 3.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GTGTAGACCGGCAAAGGCAGG	0.383000										HNSCC(58;0.16)			21	36					6.44725e-10	6.8705e-10	1	1	0
ZNFX1	57169	broad.mit.edu	37	20	47864034	47864034	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:47864034G>A	ENST00000396105.1	-	14	5773	c.5527C>T	c.(5527-5529)Cgt>Tgt	p.R1843C	ZNFX1_ENST00000371752.1_Missense_Mutation_p.R1843C|ZNFX1_ENST00000371754.4_Intron	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1843							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CAGTGACCACGAGGATAACCT	0.542000													22	28					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90145182	90145182	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:90145182C>T	ENST00000268138.7	+	12	2647	c.2542C>T	c.(2542-2544)Cgt>Tgt	p.R848C	TICRR_ENST00000560985.1_Missense_Mutation_p.R847C					TOPBP1-interacting checkpoint and replication regulator																		GCAGGAACTTCGTACCAGATC	0.408000													22	37					0	0	1	0	0
STOML2	30968	broad.mit.edu	37	9	35102754	35102754	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35102754C>T	ENST00000356493.5	-	2	174	c.112G>A	c.(112-114)Gta>Ata	p.V38I	STOML2_ENST00000452248.2_Missense_Mutation_p.V38I	NM_013442.1	NP_038470.1	Q9UJZ1	STML2_HUMAN	stomatin (EPB72)-like 2	38						cytoskeleton	receptor binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|prostate(1)	16			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ACGAACAGTACCACGGTGTTT	0.637000													26	34					0	0	1	0	0
ZNF180	7733	broad.mit.edu	37	19	44981523	44981523	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44981523C>T	ENST00000221327.4	-	5	1456	c.1175G>A	c.(1174-1176)cGg>cAg	p.R392Q	ZNF180_ENST00000391956.4_Missense_Mutation_p.R367Q|ZNF180_ENST00000592529.1_Missense_Mutation_p.R365Q	NM_013256.3	NP_037388.2	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				GTGCGAGCTCCGGCTGAAGGA	0.458000													26	65					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477099	128477099	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128477099G>A	ENST00000322313.4	-	16	2658	c.2500C>T	c.(2500-2502)Cga>Tga	p.R834*		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	834					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TGCATGCCTCGGATCTCCTGA	0.627000													3	19					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35257765	35257765	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:35257765C>T	ENST00000381318.3	+	38	5070	c.4782C>T	c.(4780-4782)ggC>ggT	p.G1594G	ITSN1_ENST00000399367.3_Silent_p.G1589G|ITSN1_ENST00000399326.3_3'UTR|ITSN1_ENST00000381285.4_Silent_p.G1594G|AP000304.12_ENST00000429238.1_Intron|ITSN1_ENST00000437442.2_Silent_p.G1533G	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	1594	C2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						GGGCAACAGGCATTGGAAGGT	0.527000													15	6					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75107402	75107402	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:75107402C>T	ENST00000290573.2	+	10	1876	c.1276C>T	c.(1276-1278)Cgt>Tgt	p.R426C	HK2_ENST00000409174.1_Missense_Mutation_p.R398C	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	426	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						TTTTGCCAAGCGTCTACATAA	0.582000													76	141					0	0	1	0	0
TMC1	117531	broad.mit.edu	37	9	75407265	75407265	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:75407265A>G	ENST00000297784.5	+	17	2103	c.1563A>G	c.(1561-1563)ggA>ggG	p.G521G	TMC1_ENST00000396237.3_Silent_p.G521G|TMC1_ENST00000340019.3_Silent_p.G521G|TMC1_ENST00000486417.1_3'UTR	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	521					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						CAATGGTGGGACAGGTAATGC	0.403000													26	176					0	0	1	0	0
ZNF384	0	broad.mit.edu	37	12	6782571	6782571	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6782571G>A	ENST00000396795.1	-	6	1219	c.722C>T	c.(721-723)tCg>tTg	p.S241L	ZNF384_ENST00000396799.2_Missense_Mutation_p.S241L|ZNF384_ENST00000355772.4_Missense_Mutation_p.S186L|ZNF384_ENST00000396801.3_Missense_Mutation_p.S241L|ZNF384_ENST00000361959.3_Missense_Mutation_p.S241L|ZNF384_ENST00000319770.3_Missense_Mutation_p.S225L			Q8TF68	ZN384_HUMAN	zinc finger protein 384	241					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						CTGCATCTCCGACTTGGAGTA	0.567000			T	"""EWSR1, TAF15 """	ALL								19	17					0	0	1	0	0
ORC3	23595	broad.mit.edu	37	6	88374517	88374517	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:88374517C>T	ENST00000392844.3	+	18	1938	c.1890C>T	c.(1888-1890)tgC>tgT	p.C630C	ORC3_ENST00000257789.4_Silent_p.C631C|ORC3_ENST00000546266.1_Silent_p.C487C	NM_012381.3|NM_181837.2	NP_036513.2|NP_862820.1	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3	630					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	28						CAGACATCTGCATAGCATACA	0.398000													24	49					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228444550	228444550	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228444550A>G	ENST00000570156.2	+	16	4858	c.4784A>G	c.(4783-4785)cAg>cGg	p.Q1595R	OBSCN_ENST00000284548.11_Missense_Mutation_p.Q1503R|OBSCN_ENST00000359599.6_Missense_Mutation_p.Q67R|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.Q1503R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	576	Ig-like 16.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GTGGTGCAGCAGGCGGGCCAG	0.657000													19	33					0	0	1	0	0
SNHG14	0	broad.mit.edu	37	15	25436481	25436481	+	RNA	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:25436481T>C	ENST00000424208.1	+	0	1076				SNHG14_ENST00000414175.1_RNA	NR_003305.1																						CACCCTGGTCTGCTGCACTGA	0.627000													37	46					0	0	1	0	0
RP1-187N21.4	0	broad.mit.edu	37	6	34392485	34392485	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:34392485G>A	ENST00000605528.1	-	3	299	c.283C>T	c.(283-285)Cgc>Tgc	p.R95C	RPS10_ENST00000326199.8_Missense_Mutation_p.R95C|RPS10_ENST00000494077.1_5'UTR|RPS10_ENST00000344700.3_Missense_Mutation_p.R95C	NM_001202470.2	NP_001189399.1																					CGGCTACGGCGTAGGGTGGCA	0.507000													11	10					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31327752	31327752	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:31327752T>C	ENST00000542188.1	-	20	3061	c.2748A>G	c.(2746-2748)cgA>cgG	p.R916R	RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000256552.6_Silent_p.R899R|TRPM1_ENST00000397795.2_Silent_p.R877R|RP11-348B17.1_ENST00000558755.1_RNA	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	877					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TAGCCACCTCTCGTATCTTCT	0.517000													13	29					0	0	1	0	0
CDH19	28513	broad.mit.edu	37	18	64212131	64212131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:64212131C>T	ENST00000262150.2	-	6	1077	c.785G>A	c.(784-786)cGc>cAc	p.R262H	CDH19_ENST00000540086.1_Missense_Mutation_p.R262H	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	262	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				GACAGTCAAGCGGTATAAACC	0.323000													7	24					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74443485	74443485	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:74443485C>A	ENST00000339953.5	-	12	1414	c.1293G>T	c.(1291-1293)caG>caT	p.Q431H		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	431	C-type lectin.					extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						TTTTGCAGCGCTGGTCGTTCC	0.597000													11	71					0.0332995	0.0334892	1	1	0
THSD7B	80731	broad.mit.edu	37	2	137917826	137917826	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:137917826G>A	ENST00000409968.1	+	6	1591	c.1413G>A	c.(1411-1413)ccG>ccA	p.P471P	THSD7B_ENST00000272643.3_Silent_p.P471P|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000485379.1_3'UTR|THSD7B_ENST00000413152.2_Silent_p.P440P					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GACCCGCCCCGTTGCCCTCTC	0.512000													29	29					0	0	1	0	0
BCMO1	53630	broad.mit.edu	37	16	81298346	81298346	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:81298346G>A	ENST00000258168.2	+	5	1034	c.573G>A	c.(571-573)aaG>aaA	p.K191K	BCMO1_ENST00000425577.2_Silent_p.K122K	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	191					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						TTGTGGAAAAGGGGAAGACAA	0.433000													9	74					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44553152	44553152	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44553152C>T	ENST00000289547.4	-	20	4029	c.3974G>A	c.(3973-3975)cGa>cAa	p.R1325Q	NPC1L1_ENST00000546276.1_Missense_Mutation_p.R1252Q|NPC1L1_ENST00000381160.3_Missense_Mutation_p.R1298Q	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1325					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	TGTGGAGACTCGGGAGGGGTG	0.582000													12	55					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11757589	11757589	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:11757589C>T	ENST00000262442.3	+	50	9845	c.9777C>T	c.(9775-9777)tcC>tcT	p.S3259S	DNAH9_ENST00000454412.2_Silent_p.S3259S	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3259	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCACCAAATCCTATGCGGCTG	0.493000													4	146					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43403513	43403513	+	Nonsense_Mutation	SNP	C	C	T	rs143947606		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43403513C>T	ENST00000244533.3	+	3	1863	c.1504C>T	c.(1504-1506)Cga>Tga	p.R502*	ABCC10_ENST00000372530.4_Nonsense_Mutation_p.R545*	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	545	ABC transmembrane type-1 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCACTGGTGCGAATGCTCAT	0.562000													8	9					0	0	1	0	0
ITIH3	3699	broad.mit.edu	37	3	52840398	52840398	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52840398C>T	ENST00000449956.2	+	18	2038	c.2032C>T	c.(2032-2034)Cgc>Tgc	p.R678C	ITIH3_ENST00000416872.2_Intron	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	678					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CACAGTGCTGCGCCTTATTCA	0.612000													24	25					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	109001440	109001440	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:109001440A>G	ENST00000276659.5	-	3	747	c.127T>C	c.(127-129)Tgt>Cgt	p.C43R	RSPO2_ENST00000378439.2_Intron|RSPO2_ENST00000517781.1_Intron|RSPO2_ENST00000517939.1_5'UTR	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	43					Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CAAGACAAACAACCCTTGCAA	0.383000													15	31					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21800813	21800813	+	Silent	SNP	G	G	A	rs41282575	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:21800813G>A	ENST00000443632.2	+	2	2001	c.1629G>A	c.(1627-1629)acG>acA	p.T543T	HIC2_ENST00000407598.2_Silent_p.T543T|HIC2_ENST00000407464.2_Silent_p.T543T			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	543					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				AAATGTTCACGCAGCGCGGCA	0.632000													17	21					0	0	1	0	0
PSAT1	29968	broad.mit.edu	37	9	80921334	80921334	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:80921334G>A	ENST00000376588.3	+	5	570	c.502G>A	c.(502-504)Gtc>Atc	p.V168I	PSAT1_ENST00000347159.2_Missense_Mutation_p.V168I	NM_058179.2	NP_478059.1	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1	168					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	TATACCCGATGTCAAGGGAGC	0.498000													109	197					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74328451	74328451	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74328451G>A	ENST00000409262.3	+	9	4131	c.4131G>A	c.(4129-4131)ccG>ccA	p.P1377P		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1377							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GAGGCAAACCGTGGAGCCCCT	0.677000													11	14					0	0	1	0	0
SERPINH1	871	broad.mit.edu	37	11	75277586	75277586	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:75277586G>T	ENST00000524558.1	+	2	1627	c.192G>T	c.(190-192)gtG>gtT	p.V64V	SERPINH1_ENST00000533603.1_Silent_p.V64V|SERPINH1_ENST00000358171.3_Silent_p.V64V|SERPINH1_ENST00000530284.1_Silent_p.V64V			P50454	SERPH_HUMAN	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	64					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			endometrium(4)|large_intestine(3)|liver(1)|lung(4)|ovary(2)|stomach(1)	15	Ovarian(111;0.11)					ACCAGGCAGTGGAGAACATCC	0.682000													11	5					1.58986e-06	1.65464e-06	1	1	0
C3orf20	84077	broad.mit.edu	37	3	14756916	14756916	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:14756916G>T	ENST00000253697.3	+	9	1886	c.1434_splice	c.e9+1	p.K478_splice	C3orf20_ENST00000435614.1_Splice_Site_p.K356_splice|C3orf20_ENST00000412910.1_Splice_Site_p.K356_splice|C3orf20_ENST00000495387.1_3'UTR	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	478						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						TGGAATACAAGGTAGGGATGG	0.577000													11	23					3.27435e-08	3.44876e-08	1	1	0
SKIV2L	6499	broad.mit.edu	37	6	31928035	31928035	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31928035C>T	ENST00000375394.2	+	4	388	c.275C>T	c.(274-276)gCt>gTt	p.A92V	SKIV2L_ENST00000488648.1_3'UTR|SKIV2L_ENST00000544581.1_Intron	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	92						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						TCTCTTTTGGCTGTCCTGGGA	0.522000													48	57					0	0	1	0	0
HERC6	55008	broad.mit.edu	37	4	89363501	89363501	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:89363501T>C	ENST00000380265.5	+	22	3033	c.2850T>C	c.(2848-2850)caT>caC	p.H950H	HERC6_ENST00000264346.7_Silent_p.H986H	NM_001165136.1	NP_001158608.1	Q8IVU3	HERC6_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	986	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		TAACTTGTCATAATATTCTCT	0.408000													9	10					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95539163	95539163	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:95539163G>A	ENST00000297591.5	-	8	1384	c.1309C>T	c.(1309-1311)Caa>Taa	p.Q437*	KIAA1429_ENST00000421249.2_Nonsense_Mutation_p.Q437*|KIAA1429_ENST00000437199.1_Nonsense_Mutation_p.Q437*	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	437					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTTAAAGCTTGCATGGTCCAG	0.398000													39	75					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7303555	7303555	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:7303555C>T	ENST00000537408.1	+	15	2997	c.2459C>T	c.(2458-2460)gCc>gTc	p.A820V	CLSTN3_ENST00000266546.6_Missense_Mutation_p.A808V			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	808					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						AACCGGGTTGCCCACCCCAGC	0.642000													9	13					0	0	1	0	0
RAB4B-EGLN2	0	broad.mit.edu	37	19	41292636	41292636	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41292636C>T	ENST00000594136.1	+	6	602	c.497C>T	c.(496-498)gCc>gTc	p.A166V	RAB4B_ENST00000594800.1_Missense_Mutation_p.A166V|RAB4B_ENST00000602069.1_3'UTR|RAB4B-EGLN2_ENST00000601949.1_3'UTR|RAB4B_ENST00000357052.2_Missense_Mutation_p.A166V																							CTCAAGTGTGCCCGCACTATC	0.637000													10	18					0	0	1	0	0
PHF17	0	broad.mit.edu	37	4	129783027	129783027	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:129783027C>G	ENST00000226319.6	+	9	1430	c.1150C>G	c.(1150-1152)Cag>Gag	p.Q384E	PHF17_ENST00000511647.1_Missense_Mutation_p.Q384E|PHF17_ENST00000512960.1_Missense_Mutation_p.Q384E|PHF17_ENST00000413543.2_Missense_Mutation_p.Q384E|PHF17_ENST00000452328.2_Missense_Mutation_p.Q372E	NM_199320.2	NP_955352.1	Q6IE81	JADE1_HUMAN		384					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGGGGCTGCACAGGAGAATGG	0.577000													7	83					0	0	1	0	0
EXOC8	149371	broad.mit.edu	37	1	231471746	231471746	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:231471746C>T	ENST00000366645.1	-	1	1852	c.1734G>A	c.(1732-1734)acG>acA	p.T578T	EXOC8_ENST00000360394.2_Silent_p.T582T			Q8IYI6	EXOC8_HUMAN	exocyst complex component 8	582					exocytosis|protein transport	growth cone|nucleus	protein binding			cervix(2)|endometrium(1)|large_intestine(2)|liver(1)|lung(5)|prostate(1)|skin(1)|stomach(1)	14	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				GGGCTTCTGGCGTCATCAAGT	0.458000													12	64					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	64061935	64061935	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:64061935C>T	ENST00000324472.4	-	1	422	c.239G>A	c.(238-240)gGc>gAc	p.G80D	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	80					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		CTGGAAGGGGCCGAGAAGAAA	0.612000													23	49					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3629159	3629159	+	Missense_Mutation	SNP	C	C	T	rs147510645		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3629159C>T	ENST00000325418.4	+	1	1949	c.1930C>T	c.(1930-1932)Cgc>Tgc	p.R644C	ITGAE_ENST00000263087.4_Intron|ITGAE_ENST00000571185.1_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	644	Protein kinase.				cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										GGCATCACTGCGCTTTGAGCA	0.512000													28	36					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2550834	2550834	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2550834G>A	ENST00000567020.1	+	7	1677	c.1537G>A	c.(1537-1539)Gat>Aat	p.D513N	TBC1D24_ENST00000293970.5_Missense_Mutation_p.D519N|TBC1D24_ENST00000434757.2_Missense_Mutation_p.D519N|RP11-20I23.1_ENST00000564543.1_Intron	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	519	TLD.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						GCTCTACATCGATGGGGACCT	0.652000											OREG0023552	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	11					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120484202	120484202	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:120484202C>A	ENST00000256646.2	-	18	3147	c.2928G>T	c.(2926-2928)caG>caT	p.Q976H		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	976	EGF-like 25; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAATCCTGCCTGGCACTTGC	0.498000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				14	24					1.49906e-05	1.54943e-05	1	1	0
FRMPD1	22844	broad.mit.edu	37	9	37745710	37745710	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:37745710G>T	ENST00000539465.1	+	16	4274	c.3681G>T	c.(3679-3681)aaG>aaT	p.K1227N	RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Missense_Mutation_p.K1227N			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1227						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		AGGGGATCAAGGCAGAGGCAC	0.507000													22	27					2.70639e-06	2.81266e-06	1	1	0
TUBB8	347688	broad.mit.edu	37	10	94613	94613	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:94613C>T	ENST00000332708.5	-	2	140	c.110G>A	c.(109-111)tGg>tAg	p.W37*	TUBB8_ENST00000309812.4_Missense_Mutation_p.M73I|TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000447903.2_Start_Codon_SNP_p.M1I			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	351					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GCACAGAGTCCATGGTGCCCG	0.697000													15	34					0	0	1	0	0
CC2D1B	200014	broad.mit.edu	37	1	52825142	52825142	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:52825142G>A	ENST00000371586.2	-	9	1145	c.1007C>T	c.(1006-1008)cCg>cTg	p.P336L	CC2D1B_ENST00000460261.1_5'UTR|CC2D1B_ENST00000284376.3_Missense_Mutation_p.P336L|CC2D1B_ENST00000438831.1_5'UTR	NM_032449.2	NP_115825.1	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	336										breast(1)|large_intestine(6)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	27						CTCAGGTGCCGGGGGCATGGC	0.622000													6	29					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129877927	129877927	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:129877927C>T	ENST00000254667.3	+	20	2275	c.1996C>T	c.(1996-1998)Cga>Tga	p.R666*	PTPRE_ENST00000306042.5_Nonsense_Mutation_p.R608*|PTPRE_ENST00000419012.2_Nonsense_Mutation_p.R666*	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	666	Tyrosine-protein phosphatase 2.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				GAAGAGTTTACGACTTCAGAG	0.418000													23	43					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242202169	242202169	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:242202169A>T	ENST00000391975.1	-	5	634	c.407T>A	c.(406-408)gTc>gAc	p.V136D	HDLBP_ENST00000391976.2_Missense_Mutation_p.V136D|HDLBP_ENST00000310931.4_Missense_Mutation_p.V136D|HDLBP_ENST00000427183.2_Missense_Mutation_p.V172D	NM_203346.3	NP_976221.1	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	136					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		AGCTTTCATGACAGCATCCAG	0.532000													9	51					0	0	1	0	0
TNFAIP8	25816	broad.mit.edu	37	5	118728702	118728702	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:118728702C>A	ENST00000504771.2	+	2	2000	c.223C>A	c.(223-225)Ctc>Atc	p.L75I	TNFAIP8_ENST00000504642.1_Missense_Mutation_p.L77I|TNFAIP8_ENST00000415806.2_3'UTR|TNFAIP8_ENST00000503646.1_Missense_Mutation_p.L75I|TNFAIP8_ENST00000513374.1_Missense_Mutation_p.L87I|TNFAIP8_ENST00000274456.6_Missense_Mutation_p.L65I	NM_014350.2	NP_055165.2	O95379	TFIP8_HUMAN	tumor necrosis factor, alpha-induced protein 8	75					anti-apoptosis|apoptosis|negative regulation of anti-apoptosis	cytoplasm	caspase inhibitor activity|protein binding			ovary(1)	1		all_cancers(142;0.0317)|Prostate(80;0.111)|Breast(839;0.231)		Epithelial(69;4.63e-83)|OV - Ovarian serous cystadenocarcinoma(64;1.39e-82)|all cancers(49;4.88e-75)|GBM - Glioblastoma multiforme(465;0.00338)|BRCA - Breast invasive adenocarcinoma(61;0.0148)|COAD - Colon adenocarcinoma(49;0.0829)		CATCAAGAACCTCATCAAGAC	0.408000													6	8					0.00116845	0.0011864	1	1	0
ZWILCH	55055	broad.mit.edu	37	15	66813467	66813467	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:66813467C>T	ENST00000307897.5	+	7	1051	c.671C>T	c.(670-672)gCg>gTg	p.A224V	RPL4_ENST00000564517.1_Intron|ZWILCH_ENST00000446801.2_Missense_Mutation_p.A110V|RPL4_ENST00000568588.1_Intron|ZWILCH_ENST00000535141.2_Missense_Mutation_p.A110V|ZWILCH_ENST00000565627.1_Missense_Mutation_p.A110V	NM_017975.3	NP_060445.3	Q9H900	ZWILC_HUMAN	zwilch kinetochore protein	224					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(1)|lung(6)|ovary(1)	18						TCACAAACTGCGATCGCTTTG	0.458000													105	178					0	0	1	0	0
CEP135	9662	broad.mit.edu	37	4	56890766	56890766	+	Silent	SNP	G	G	A	rs145993112		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:56890766G>A	ENST00000257287.4	+	25	3544	c.3420G>A	c.(3418-3420)gtG>gtA	p.V1140V		NM_025009.4	NP_079285.2	Q66GS9	CP135_HUMAN	centrosomal protein 135kDa	1140					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					ATAGAAATGTGTAATTATCAG	0.423000													70	98					0	0	1	0	0
FAM13B	0	broad.mit.edu	37	5	137288395	137288395	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137288395A>T	ENST00000033079.3	-	16	2237	c.1786T>A	c.(1786-1788)Tcc>Acc	p.S596T	FAM13B_ENST00000425075.2_Missense_Mutation_p.S500T|FAM13B_ENST00000420893.2_Missense_Mutation_p.S596T	NM_016603.2	NP_057687.2	Q9NYF5	FA13B_HUMAN	family with sequence similarity 13, member B	596					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(4)|kidney(2)|lung(5)	11						TCACTGTAGGAGGGCTGAAAA	0.348000													39	58					0	0	1	0	0
ZMYND15	84225	broad.mit.edu	37	17	4645350	4645350	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4645350C>T	ENST00000433935.1	+	4	1025	c.968C>T	c.(967-969)gCg>gTg	p.A323V	ZMYND15_ENST00000269289.6_Missense_Mutation_p.A323V|ZMYND15_ENST00000592813.1_Missense_Mutation_p.A323V|ZMYND15_ENST00000573751.2_Missense_Mutation_p.A323V	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	323							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						AGCTTTGAAGCGAAGCTGACA	0.597000													24	56					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19693654	19693654	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:19693654C>T	ENST00000438132.3	+	28	2784	c.2736C>T	c.(2734-2736)tgC>tgT	p.C912C	C16orf62_ENST00000448695.1_Silent_p.C673C|C16orf62_ENST00000543152.1_Silent_p.C572C|C16orf62_ENST00000542263.1_Silent_p.C819C|C16orf62_ENST00000417362.2_Silent_p.C730C|C16orf62_ENST00000251143.5_Silent_p.C823C	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	823						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						TCTACACCTGCGTCCTGCATC	0.532000													29	41					0	0	1	0	0
KAT2A	2648	broad.mit.edu	37	17	40265744	40265744	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40265744C>T	ENST00000225916.5	-	18	2490	c.2437G>A	c.(2437-2439)Gag>Aag	p.E813K		NM_021078.2	NP_066564.2	Q92830	KAT2A_HUMAN	K(lysine) acetyltransferase 2A	813	Bromo.				chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						CGGCAGTACTCGCTGTCCGGG	0.617000													23	23					0	0	1	0	0
MEIS2	4212	broad.mit.edu	37	15	37188835	37188835	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:37188835G>A	ENST00000338564.5	-	11	1476	c.1030C>T	c.(1030-1032)Cga>Tga	p.R344*	MEIS2_ENST00000559408.1_5'UTR|MEIS2_ENST00000382766.2_Nonsense_Mutation_p.R344*|MEIS2_ENST00000561208.1_Nonsense_Mutation_p.R344*|MEIS2_ENST00000397624.3_Nonsense_Mutation_p.R256*|MEIS2_ENST00000340545.5_Nonsense_Mutation_p.R331*|MEIS2_ENST00000397620.2_Nonsense_Mutation_p.R256*|MEIS2_ENST00000219869.9_Nonsense_Mutation_p.R198*|MEIS2_ENST00000424352.2_Nonsense_Mutation_p.R344*|MEIS2_ENST00000444725.1_Nonsense_Mutation_p.R344*|MEIS2_ENST00000559561.1_Nonsense_Mutation_p.R344*|MEIS2_ENST00000559085.1_Nonsense_Mutation_p.R331*|MEIS2_ENST00000557796.2_Nonsense_Mutation_p.R331*	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	344					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity	p.R344*(2)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		TTGCCTGCTCGATTTGACTGG	0.398000													41	45					0	0	1	0	0
GOLPH3L	55204	broad.mit.edu	37	1	150621038	150621038	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:150621038C>T	ENST00000271732.3	-	5	661	c.617G>A	c.(616-618)aGt>aAt	p.S206N	GOLPH3L_ENST00000540514.1_Missense_Mutation_p.S162N	NM_018178.5	NP_060648.2	Q9H4A5	GLP3L_HUMAN	golgi phosphoprotein 3-like	206						Golgi cisterna membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)	8	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			CTCTAGTACACTATCTTGAAG	0.458000													10	30					0	0	1	0	0
MS4A5	64232	broad.mit.edu	37	11	60215171	60215171	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:60215171C>A	ENST00000300190.2	+	5	628	c.542C>A	c.(541-543)tCt>tAt	p.S181Y		NM_023945.2	NP_076434.2	Q9H3V2	MS4A5_HUMAN	membrane-spanning 4-domains, subfamily A, member 5	181						integral to membrane	receptor activity			large_intestine(7)|lung(7)|ovary(1)|skin(1)	16						TTATTCATTTCTCTGCCTTTC	0.333000													39	63					1.96642e-18	2.17001e-18	1	1	0
TRPC3	7222	broad.mit.edu	37	4	122825550	122825550	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:122825550T>C	ENST00000264811.5	-	7	2379	c.1961A>G	c.(1960-1962)tAc>tGc	p.Y654C	TRPC3_ENST00000379645.3_Missense_Mutation_p.Y727C|TRPC3_ENST00000513531.1_Missense_Mutation_p.Y599C	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	642					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						AGTTACATTGTATATTCCATA	0.318000													34	122					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111216429	111216429	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:111216429C>T	ENST00000369769.2	-	1	1226	c.1003G>A	c.(1003-1005)Gcc>Acc	p.A335T		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	335						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGAATGATGGCCACAATGTCG	0.537000													22	34					0	0	1	0	0
FAM167B	84734	broad.mit.edu	37	1	32713183	32713183	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32713183C>T	ENST00000373582.3	+	1	350	c.161C>T	c.(160-162)gCc>gTc	p.A54V		NM_032648.2	NP_116037.2	Q9BTA0	F167B_HUMAN	family with sequence similarity 167, member B	54										endometrium(1)|large_intestine(1)|lung(1)|ovary(2)	5						CAGAGCCAGGCCTGGCGCAGG	0.647000													8	16					0	0	1	0	0
MRPL11	65003	broad.mit.edu	37	11	66203543	66203543	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66203543C>T	ENST00000310999.7	-	5	607	c.514G>A	c.(514-516)Gcc>Acc	p.A172T	MRPL11_ENST00000329819.4_3'UTR|MRPL11_ENST00000430466.2_Missense_Mutation_p.A146T|MRPL11_ENST00000524576.1_5'UTR	NM_016050.3	NP_057134.1	Q9Y3B7	RM11_HUMAN	mitochondrial ribosomal protein L11	172					translation		structural constituent of ribosome			endometrium(3)|lung(2)|ovary(1)|prostate(1)	7						AGGAAGATGGCTCGTTCCTTC	0.527000													29	35					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48798701	48798701	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:48798701C>T	ENST00000314191.2	-	37	4633	c.4577G>A	c.(4576-4578)cGc>cAc	p.R1526H	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.R1526H	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	1527	Interaction with C1D.|Leucine-zipper.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACTCACAAGGCGCTCACACTG	0.512000								Non-homologous end-joining					5	8					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11422233	11422233	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:11422233G>T	ENST00000423059.3	-	24	4673	c.4422C>A	c.(4420-4422)tgC>tgA	p.C1474*	AC004538.3_ENST00000421121.1_RNA|AC004538.3_ENST00000595972.1_RNA|AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1474	TSP type-1 15.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TATATTCATAGCACTGTCCAT	0.398000										HNSCC(18;0.044)			3	8					0.004672	0.00472505	1	1	0
ACAA1	30	broad.mit.edu	37	3	38167088	38167088	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38167088C>T	ENST00000333167.8	-	11	1339	c.1167G>A	c.(1165-1167)acG>acA	p.T389T	ACAA1_ENST00000450296.1_Silent_p.T348T|ACAA1_ENST00000480865.1_5'UTR|ACAA1_ENST00000301810.7_Silent_p.T296T	NM_001607.3	NP_001598.1	P09110	THIK_HUMAN	acetyl-CoA acyltransferase 1	389					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy	peroxisomal matrix	acetyl-CoA C-acyltransferase activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0523)|Kidney(284;0.0657)		CATTGAGCAGCGTGATGACCT	0.627000													11	26					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71267462	71267462	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:71267462G>A	ENST00000554752.2	-	2	741	c.742C>T	c.(742-744)Cag>Tag	p.Q248*	MAP3K9_ENST00000555993.2_Nonsense_Mutation_p.Q248*|MAP3K9_ENST00000381250.4_Nonsense_Mutation_p.Q248*			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	248	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CTGGCAATCTGCACAGCCCAA	0.493000													41	47					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70471081	70471081	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:70471081C>T	ENST00000373998.1	-	4	1422	c.725G>A	c.(724-726)cGc>cAc	p.R242H	ZMYM3_ENST00000373984.3_Missense_Mutation_p.R244H|ZMYM3_ENST00000373981.1_Missense_Mutation_p.R242H|ZMYM3_ENST00000373988.1_Missense_Mutation_p.R244H|ZMYM3_ENST00000314425.5_Missense_Mutation_p.R242H|ZMYM3_ENST00000353904.2_Missense_Mutation_p.R242H|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373982.1_Missense_Mutation_p.R244H|ZMYM3_ENST00000373978.1_Missense_Mutation_p.R244H	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	242					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					TCTCCTAACGCGCTCGCTTCT	0.522000													13	5					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50716563	50716563	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50716563G>A	ENST00000449103.1	-	31	5010	c.4870C>T	c.(4870-4872)Cgg>Tgg	p.R1624W	PLXNB2_ENST00000359337.4_Missense_Mutation_p.R1624W			O15031	PLXB2_HUMAN	plexin B2	1624					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GAGAGCAGCCGCGTCAGGTAG	0.692000													4	22					0	0	1	0	0
PROKR1	10887	broad.mit.edu	37	2	68882132	68882132	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:68882132C>T	ENST00000303786.3	+	3	1026	c.606C>T	c.(604-606)acC>acT	p.T202T	PROKR1_ENST00000394342.2_Silent_p.T202T			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	202						integral to membrane|plasma membrane	neuropeptide Y receptor activity	p.T202T(1)		endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						ACTTCACCACCGAGACGGTCC	0.557000													36	58					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55020209	55020209	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:55020209C>T	ENST00000324000.3	+	1	2166	c.132C>T	c.(130-132)taC>taT	p.Y44Y		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	44					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CTCCCAAGTACGCCAGCCCGG	0.582000													21	23					0	0	1	0	0
ATF6	22926	broad.mit.edu	37	1	161789584	161789584	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161789584G>A	ENST00000367942.3	+	8	1138	c.1071G>A	c.(1069-1071)cgG>cgA	p.R357R		NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	357	Leucine-zipper.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			CACTGAAGCGGCAGCTGGATG	0.413000													5	23					0	0	1	0	0
GOSR2	9570	broad.mit.edu	37	17	45012589	45012589	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:45012589A>G	ENST00000415811.2	+	5	586	c.531A>G	c.(529-531)caA>caG	p.Q177Q	GOSR2_ENST00000576910.2_Intron|RP11-156P1.2_ENST00000571841.1_Intron|GOSR2_ENST00000393456.2_Intron|GOSR2_ENST00000225567.4_Intron|GOSR2_ENST00000439730.2_Intron	NM_001012511.1	NP_001012529.1	O14653	GOSR2_HUMAN	golgi SNAP receptor complex member 2	172					cellular membrane fusion|ER to Golgi vesicle-mediated transport|protein transport	Golgi membrane|integral to membrane	transporter activity			kidney(1)|large_intestine(2)|liver(1)|lung(1)|ovary(1)|skin(1)	7			BRCA - Breast invasive adenocarcinoma(9;0.102)			GCCTCATCCAACAGTTTAGTA	0.448000													10	22					0	0	1	0	0
DYRK1B	9149	broad.mit.edu	37	19	40316606	40316606	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:40316606G>A	ENST00000593685.1	-	11	2107	c.1639C>T	c.(1639-1641)Cga>Tga	p.R547*	DYRK1B_ENST00000597639.1_Nonsense_Mutation_p.R519*|DYRK1B_ENST00000348817.3_Nonsense_Mutation_p.R519*|DYRK1B_ENST00000323039.5_Nonsense_Mutation_p.R547*|DYRK1B_ENST00000430012.2_Nonsense_Mutation_p.R507*			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	547					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CCAAGGTATCGGGGCTGGGGG	0.687000													19	26					0	0	1	0	0
WWC1	23286	broad.mit.edu	37	5	167798441	167798441	+	Silent	SNP	G	G	A	rs142947087	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:167798441G>A	ENST00000265293.4	+	2	634	c.132G>A	c.(130-132)ccG>ccA	p.P44P	WWC1_ENST00000521089.1_Silent_p.P44P	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	44					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		ACACCAAACCGCTCACCTTTG	0.517000													6	12					0	0	1	0	0
OR2T29	343563	broad.mit.edu	37	1	248722771	248722771	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:248722771C>T	ENST00000328570.3	-	1	26	c.22G>A	c.(22-24)Gcc>Acc	p.A8T	RP11-438F14.3_ENST00000438623.1_RNA	NM_001004694.2	NP_001004694.2	Q8NH02	O2T29_HUMAN	olfactory receptor, family 2, subfamily T, member 29	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|lung(4)	5	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGTGGTTGGCCATCCTGGTG	0.468000													4	34					0	0	1	0	0
CUL1	8454	broad.mit.edu	37	7	148457470	148457470	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:148457470C>T	ENST00000325222.4	+	7	950	c.671C>T	c.(670-672)aCg>aTg	p.T224M	CUL1_ENST00000602748.1_Missense_Mutation_p.T224M|CUL1_ENST00000409469.1_Missense_Mutation_p.T224M	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	224					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			AAGGGCCCTACGTTAACAGTG	0.358000													45	77					0	0	1	0	0
RLN2	6019	broad.mit.edu	37	9	5300248	5300248	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:5300248T>C	ENST00000381627.3	-	2	796	c.408A>G	c.(406-408)agA>agG	p.R136R	RLN2_ENST00000308420.3_3'UTR	NM_134441.2	NP_604390.1	P04090	REL2_HUMAN	relaxin 2	136					female pregnancy	extracellular region	hormone activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	11	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.0987)		CTTCACTTTGTCTATTGCGAA	0.383000													51	68					0	0	1	0	0
PLD2	5338	broad.mit.edu	37	17	4725959	4725959	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4725959G>A	ENST00000263088.6	+	25	2733	c.2602G>A	c.(2602-2604)Gcc>Acc	p.A868T	PLD2_ENST00000572940.1_Missense_Mutation_p.A857T	NM_001243108.1|NM_002663.4	NP_001230037.1|NP_002654.3	O14939	PLD2_HUMAN	phospholipase D2	868					cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)	31					Choline(DB00122)	GCCATCCAATGCCACGCGTTC	0.642000													32	23					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92477386	92477386	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:92477386G>A	ENST00000267622.4	-	9	1631	c.1258C>T	c.(1258-1260)Ctt>Ttt	p.L420F		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	420					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		CGCATTTTAAGTTTCAGATTG	0.338000			T	PDGFRB	AML								19	37					0	0	1	0	0
TIRAP	114609	broad.mit.edu	37	11	126162971	126162971	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:126162971G>A	ENST00000392678.3	+	5	1096	c.667G>A	c.(667-669)Gaa>Aaa	p.E223K	TIRAP_ENST00000392679.1_Intron|TIRAP_ENST00000392680.2_Intron|RP11-712L6.7_ENST00000533378.1_RNA	NM_148910.2	NP_683708.1	P58753	TIRAP_HUMAN	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0					3'-UTR-mediated mRNA stabilization|cellular response to bacterial lipopeptide|cellular response to lipoteichoic acid|defense response to Gram-positive bacterium|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|myeloid cell differentiation|negative regulation of growth of symbiont in host|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 1 production|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of ERK1 and ERK2 cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-12 production|positive regulation of interleukin-15 production|positive regulation of interleukin-6 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of JNK cascade|positive regulation of neutrophil chemotaxis|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein homodimerization activity|positive regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|regulation of interferon-beta production|response to lipopolysaccharide|TIRAP-dependent toll-like receptor 4 signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway	endocytic vesicle|intrinsic to membrane|ruffle membrane	phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|protein heterodimerization activity|protein homodimerization activity|protein kinase C delta binding|Toll-like receptor 2 binding|Toll-like receptor 4 binding|transmembrane receptor activity			breast(1)|endometrium(1)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	6	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0739)		ACAGGAGGGAGAAGGGGAACG	0.498000													11	13					0	0	1	0	0
PLA2G15	23659	broad.mit.edu	37	16	68293284	68293284	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:68293284G>A	ENST00000219345.5	+	6	1046	c.963G>A	c.(961-963)acG>acA	p.T321T	PLA2G15_ENST00000413021.2_Silent_p.T227T|PLA2G15_ENST00000444212.2_Silent_p.T121T|RP11-96D1.7_ENST00000563175.1_RNA|PLA2G15_ENST00000566188.1_3'UTR	NM_012320.3	NP_036452.1	Q8NCC3	PAG15_HUMAN	phospholipase A2, group XV	321					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			kidney(2)|large_intestine(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	12						TGGAAGCCACGATGCCACCTG	0.567000													14	39					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18260483	18260483	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18260483G>A	ENST00000262811.5	+	27	3877	c.3877G>A	c.(3877-3879)Gtg>Atg	p.V1293M	AC007192.6_ENST00000600364.1_RNA	NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3	1293							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						ACAGATCGCCGTGGAGGGCGA	0.622000													11	24					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16908688	16908688	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16908688G>A	ENST00000524140.2	+	16	3868	c.3450G>A	c.(3448-3450)gcG>gcA	p.A1150A	NWD1_ENST00000339803.6_Silent_p.A1015A|NWD1_ENST00000523826.1_Silent_p.A944A|NWD1_ENST00000552788.1_Silent_p.A1150A|NWD1_ENST00000379808.3_Silent_p.A1150A|NWD1_ENST00000549814.1_Silent_p.A1150A	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1150							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CCCTTGATGCGCTCATTCAGG	0.507000													63	108					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66461832	66461832	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66461832C>T	ENST00000533211.1	-	22	4612	c.4281G>A	c.(4279-4281)atG>atA	p.M1427I	SPTBN2_ENST00000309996.2_Missense_Mutation_p.M1427I|SPTBN2_ENST00000529997.1_Missense_Mutation_p.M1427I			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1427					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CCCATTCCAGCATCTGCAAAC	0.597000											OREG0021113	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	17					0	0	1	0	0
RBM44	375316	broad.mit.edu	37	2	238732966	238732966	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:238732966T>C	ENST00000316997.4	+	10	2488	c.2356T>C	c.(2356-2358)Tgg>Cgg	p.W786R	RBM44_ENST00000409864.1_Missense_Mutation_p.W786R	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	785							nucleotide binding|RNA binding	p.W786R(1)		breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		AAGCGAAGACTGGTCTGATGC	0.443000													9	16					0	0	1	0	0
PCDHA6	0	broad.mit.edu	37	5	140209590	140209590	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140209590C>T	ENST00000529310.1	+	1	2028	c.1914C>T	c.(1912-1914)gaC>gaT	p.D638D	PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGTCCTGGACGAAGCGGACT	0.667000													27	58					0	0	1	0	0
SCN1B	6324	broad.mit.edu	37	19	35523489	35523489	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35523489G>A	ENST00000262631.5	+	2	235	c.98G>A	c.(97-99)gGg>gAg	p.G33E	SCN1B_ENST00000415950.3_Missense_Mutation_p.G33E|SCN1B_ENST00000596348.1_3'UTR|SCN1B_ENST00000595652.1_Missense_Mutation_p.G33E	NM_001037.4	NP_001028.1	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta subunit	33	Ig-like C2-type.				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	11	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCCGTGTATGGGATGACCTTC	0.622000													11	63					0	0	1	0	0
PIAS4	51588	broad.mit.edu	37	19	4013216	4013216	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4013216A>G	ENST00000262971.2	+	2	438	c.323A>G	c.(322-324)tAc>tGc	p.Y108C		NM_015897.2	NP_056981.2	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	108					positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(3)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		AATATTGACTACCCCGTGCTC	0.627000													21	35					0	0	1	0	0
RBM33	155435	broad.mit.edu	37	7	155534615	155534615	+	Missense_Mutation	SNP	G	G	A	rs148804732		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:155534615G>A	ENST00000401878.3	+	13	2350	c.2152G>A	c.(2152-2154)Gtg>Atg	p.V718M		NM_053043.2	NP_444271.2	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	718							nucleotide binding|RNA binding			breast(3)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	27	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		GCCGTCACACGTGATAGAAAT	0.577000													26	33					0	0	1	0	0
OGFOD3	79701	broad.mit.edu	37	17	80364301	80364301	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80364301G>T	ENST00000313056.5	-	5	632	c.481C>A	c.(481-483)Ctg>Atg	p.L161M	OGFOD3_ENST00000329197.5_Missense_Mutation_p.L161M	NM_024648.2|NM_175902.4	NP_078924.1|NP_787098.3			2-oxoglutarate and iron-dependent oxygenase domain containing 3																		CACCTGTACAGGTTCACAAAG	0.567000													14	28					2.32078e-09	2.46314e-09	1	1	0
WDR7	23335	broad.mit.edu	37	18	54398626	54398626	+	Missense_Mutation	SNP	G	G	A	rs147676543		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:54398626G>A	ENST00000254442.3	+	14	1998	c.1787G>A	c.(1786-1788)cGt>cAt	p.R596H	WDR7_ENST00000357574.3_Missense_Mutation_p.R596H|WDR7_ENST00000589935.1_Intron	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	596										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		GCATTGGATCGTTGTGTGATG	0.343000													11	32					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171605301	171605301	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:171605301C>T	ENST00000037502.5	-	3	1338	c.1279G>A	c.(1279-1281)Gcc>Acc	p.A427T		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	427	Olfactomedin-like.		A -> T (in GLC1A).		anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AAGGCATTGGCGACTGACTGC	0.512000													48	66					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21120417	21120417	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:21120417G>A	ENST00000377122.4	-	15	1941	c.1545C>T	c.(1543-1545)tcC>tcT	p.S515S	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	515					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TGGCCATCTCGGATGCTTTCT	0.428000													11	31					0	0	1	0	0
UCK2	7371	broad.mit.edu	37	1	165865434	165865434	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:165865434G>A	ENST00000367879.4	+	4	667	c.364G>A	c.(364-366)Gag>Aag	p.E122K	RP11-525G13.2_ENST00000455257.1_RNA|UCK2_ENST00000372212.4_Intron	NM_012474.4	NP_036606.2	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	122					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					CAGGAAGGAGGAGACAGTTAC	0.547000													10	166					0	0	1	0	0
CDCA3	83461	broad.mit.edu	37	12	6958354	6958354	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6958354C>T	ENST00000538862.2	-	6	1561	c.660G>A	c.(658-660)cgG>cgA	p.R220R	CDCA3_ENST00000535406.1_Silent_p.R220R|CDCA3_ENST00000229265.6_Silent_p.R195R|CDCA3_ENST00000540683.1_3'UTR|CDCA3_ENST00000422785.3_Intron			Q99618	CDCA3_HUMAN	cell division cycle associated 3	220					cell division|mitosis	cytosol				breast(1)|endometrium(1)|large_intestine(4)|lung(1)|stomach(1)	8						GGGGTGAAGGCCGCTTACCCT	0.507000													8	19					0	0	1	0	0
SLC4A1	6521	broad.mit.edu	37	17	42335881	42335881	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42335881C>T	ENST00000262418.6	-	10	1142	c.987G>A	c.(985-987)gaG>gaA	p.E329E	AC003043.1_ENST00000597382.1_Intron	NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	329					bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		GCAGTGCCTGCTCGGAGGGGG	0.622000													14	30					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77629784	77629784	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:77629784G>A	ENST00000407578.2	-	80	13822	c.13556C>T	c.(13555-13557)gCt>gTt	p.A4519V	MYCBP2_ENST00000544440.2_Missense_Mutation_p.A4481V|MYCBP2_ENST00000357337.6_Missense_Mutation_p.A4481V	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	4481					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGTTGTGATAGCTTCACTCTT	0.373000													24	14					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35632932	35632932	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:35632932G>A	ENST00000353139.5	-	8	1294	c.813C>T	c.(811-813)agC>agT	p.S271S	ACACA_ENST00000394406.2_Silent_p.S234S|ACACA_ENST00000360679.3_Silent_p.S176S|ACACA_ENST00000335166.5_Silent_p.S156S	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	234	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ACATGGCCTGGCTTGGAGGAC	0.463000													23	38					0	0	1	0	0
AC079776.7	0	broad.mit.edu	37	2	130725847	130725847	+	RNA	SNP	C	C	T	rs151288976	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:130725847C>T	ENST00000412425.1	-	0	771					NR_036537.1																						TTGGTTTTGGCGCTTCTGTTG	0.478000													14	15					0	0	1	0	0
DEPDC1	55635	broad.mit.edu	37	1	68954165	68954165	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:68954165G>A	ENST00000456315.2	-	5	727	c.613C>T	c.(613-615)Cca>Tca	p.P205S	DEPDC1_ENST00000370966.5_Missense_Mutation_p.P205S	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	205					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		TCTAGGGATGGCACACCTAAA	0.303000													16	27					0	0	1	0	0
TCAIM	285343	broad.mit.edu	37	3	44448965	44448965	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:44448965G>A	ENST00000342649.4	+	11	1709	c.1282G>A	c.(1282-1284)Gca>Aca	p.A428T	TCAIM_ENST00000417237.1_Missense_Mutation_p.A428T	NM_173826.3	NP_776187.2			T cell activation inhibitor, mitochondrial																		ATTGATACAGGCATCAACAAA	0.284000													26	35					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	420486	420486	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:420486A>G	ENST00000432829.2	+	31	4038	c.3722A>G	c.(3721-3723)cAg>cGg	p.Q1241R	DOCK8_ENST00000493666.2_3'UTR|DOCK8_ENST00000453981.1_Missense_Mutation_p.Q1309R|DOCK8_ENST00000469391.1_Missense_Mutation_p.Q1209R|DOCK8_ENST00000382329.1_Missense_Mutation_p.Q776R	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1309					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AATGCTGATCAGAGCCTCATT	0.448000													39	45					0	0	1	0	0
ZNF484	83744	broad.mit.edu	37	9	95618579	95618579	+	Missense_Mutation	SNP	C	C	T	rs143365202		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95618579C>T	ENST00000375495.3	-	3	185	c.37G>A	c.(37-39)Gta>Ata	p.V13I	ANKRD19P_ENST00000473204.1_RNA|ZNF484_ENST00000395505.2_5'UTR|ZNF484_ENST00000332591.6_5'UTR|ZNF484_ENST00000395506.3_Missense_Mutation_p.V15I	NM_031486.2	NP_113674.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	13	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						TCTACAGTTACGTCCTTGAAT	0.308000													30	44					0	0	1	0	0
NDN	4692	broad.mit.edu	37	15	23931681	23931681	+	Silent	SNP	G	G	A	rs149718513		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:23931681G>A	ENST00000331837.4	-	1	769	c.684C>T	c.(682-684)ttC>ttT	p.F228F		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	228	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding	p.F228F(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		GCACGTCCCCGAAGGTGGAGT	0.602000									Prader-Willi syndrome				14	25					0	0	1	0	0
SCN1B	6324	broad.mit.edu	37	19	35530127	35530127	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35530127C>T	ENST00000262631.5	+	4	692	c.555C>T	c.(553-555)atC>atT	p.I185I	SCN1B_ENST00000595652.1_Silent_p.I114I	NM_001037.4	NP_001028.1	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta subunit	185					axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	11	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ACAAGAAGATCGCTGCCGCCA	0.552000													34	41					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52556356	52556356	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52556356G>A	ENST00000321725.6	+	60	6552	c.6476G>A	c.(6475-6477)cGc>cAc	p.R2159H		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	2159	EGF-like 16.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		AACACACGGCGCTGTGAGTGC	0.657000													4	46					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119188348	119188348	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:119188348G>A	ENST00000313400.4	-	23	3902	c.3802C>T	c.(3802-3804)Cgg>Tgg	p.R1268W	ASTN2_ENST00000373996.3_Missense_Mutation_p.R1264W|ASTN2_ENST00000341734.4_Missense_Mutation_p.R320W|ASTN2_ENST00000361477.3_Missense_Mutation_p.R320W|ASTN2_ENST00000361209.2_Missense_Mutation_p.R1217W|ASTN2_ENST00000288520.5_Missense_Mutation_p.R369W			O75129	ASTN2_HUMAN	astrotactin 2	1268						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TCCAGTCGCCGTAGAATCAGG	0.522000													8	12					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9281097	9281097	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:9281097C>T	ENST00000383440.2	+	12	6350	c.6093C>T	c.(6091-6093)aaC>aaT	p.N2031N	ANKRD12_ENST00000400020.3_Silent_p.N2031N|ANKRD12_ENST00000262126.3_Silent_p.N2054N	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	2054						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						TTGATGTTAACGACGACTTTG	0.403000													36	57					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36367818	36367818	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:36367818C>T	ENST00000373204.4	+	11	1490	c.1277C>T	c.(1276-1278)gCc>gTc	p.A426V	AGO1_ENST00000373206.1_Missense_Mutation_p.A351V	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		CGGGCCATTGCCACACCCAAT	0.572000													41	69					0	0	1	0	0
SDS	10993	broad.mit.edu	37	12	113830893	113830893	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:113830893G>A	ENST00000257549.4	-	8	962	c.840C>T	c.(838-840)caC>caT	p.H280H		NM_006843.2	NP_006834.2	P20132	SDHL_HUMAN	serine dehydratase	280					gluconeogenesis|L-serine catabolic process|pyruvate biosynthetic process	cytoplasm	L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|protein homodimerization activity|pyridoxal phosphate binding			large_intestine(2)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(1)	11					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	TCTGGATCACGTGGCTATAGA	0.647000													34	41					0	0	1	0	0
TMEM8A	58986	broad.mit.edu	37	16	422141	422141	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:422141G>A	ENST00000431232.2	-	13	2322	c.2162C>T	c.(2161-2163)aCc>aTc	p.T721I	TMEM8A_ENST00000250930.3_Missense_Mutation_p.T528I	NM_021259.2	NP_067082.2	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8A	721					cell adhesion	integral to plasma membrane				central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	14						GATGCTGTGGGTGTAGTAGTA	0.642000													15	19					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169656274	169656274	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:169656274C>T	ENST00000428432.2	+	9	1710	c.1321C>T	c.(1321-1323)Cga>Tga	p.R441*	SAMD7_ENST00000335556.3_Nonsense_Mutation_p.R441*	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	441										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AGGAATTGAGCGAGGTAGTAT	0.413000													15	24					0	0	1	0	0
JMJD4	65094	broad.mit.edu	37	1	227920225	227920225	+	Silent	SNP	G	G	A	rs139531103		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:227920225G>A	ENST00000366758.3	-	6	1259	c.1260C>T	c.(1258-1260)cgC>cgT	p.R420R	SNAP47_ENST00000480897.1_3'UTR|JMJD4_ENST00000485807.1_5'UTR|JMJD4_ENST00000438896.2_Silent_p.R404R|SNAP47_ENST00000366760.1_Intron	NM_023007.2	NP_075383.2	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4	420										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	9		Prostate(94;0.0885)				CCTCTGTGATGCGCCCAACAT	0.612000													16	18					0	0	1	0	0
ZBTB43	23099	broad.mit.edu	37	9	129595902	129595902	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:129595902C>T	ENST00000373464.4	+	3	1378	c.1114C>T	c.(1114-1116)Ctg>Ttg	p.L372L	ZBTB43_ENST00000373457.1_Silent_p.L372L|ZBTB43_ENST00000449886.1_Silent_p.L372L	NM_014007.3	NP_054726.1	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						CACTGACAAGCTGTATCCTTG	0.502000													19	28					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219292746	219292746	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219292746G>A	ENST00000248444.5	+	5	494	c.406G>A	c.(406-408)Gtc>Atc	p.V136I	VIL1_ENST00000440053.1_Missense_Mutation_p.V136I|VIL1_ENST00000392114.2_Intron	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	136	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCCTATGACGTCCAGAGGCT	0.622000													41	71					0	0	1	0	0
CHD1	1105	broad.mit.edu	37	5	98192375	98192375	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:98192375A>G	ENST00000284049.3	-	35	4991	c.4842T>C	c.(4840-4842)gaT>gaC	p.D1614D		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1614					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TTGACCTGTGATCTCTACTCC	0.353000													9	17					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71069250	71069250	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:71069250C>T	ENST00000452400.2	-	11	1531	c.1350G>A	c.(1348-1350)gtG>gtA	p.V450V	NCOA2_ENST00000524223.1_Intron	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	450					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GCATGCCTGACACATGGTTCA	0.502000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								16	26					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144857655	144857655	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:144857655G>T	ENST00000369359.4	-	42	6845	c.6807C>A	c.(6805-6807)tcC>tcA	p.S2269S	PDE4DIP_ENST00000530740.1_Silent_p.S2218S|PDE4DIP_ENST00000369354.3_Silent_p.S2133S|PDE4DIP_ENST00000313382.9_Silent_p.S2027S|PDE4DIP_ENST00000369356.4_Silent_p.S2133S|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2133					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAGGAGTAGAGGAAGCAGAGC	0.493000			T	PDGFRB	MPD								18	122					3.32936e-07	3.48341e-07	1	1	0
COPG2	26958	broad.mit.edu	37	7	130297071	130297071	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:130297071C>T	ENST00000445977.2	-	8	620	c.531G>A	c.(529-531)tgG>tgA	p.W177*				Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2	177					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity			large_intestine(1)	1	Melanoma(18;0.0435)					CTTCATTGATCCAGCGCTTAA	0.353000													8	30					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104030070	104030070	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:104030070G>T	ENST00000265148.3	-	48	7990	c.7901C>A	c.(7900-7902)cCt>cAt	p.P2634H	CENPE_ENST00000380026.3_Missense_Mutation_p.P2513H	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	2634	Globular autoinhibitory domain (By similarity).				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CTTTGGCACAGGATCTTGTAA	0.383000													35	60					6.84511e-11	7.33645e-11	1	1	0
STK25	10494	broad.mit.edu	37	2	242441080	242441080	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:242441080C>T	ENST00000316586.4	-	3	423	c.74G>A	c.(73-75)cGc>cAc	p.R25H	STK25_ENST00000401869.1_Missense_Mutation_p.R25H|STK25_ENST00000535007.1_5'UTR|STK25_ENST00000405883.3_Intron|STK25_ENST00000403346.3_Missense_Mutation_p.R25H|STK25_ENST00000405585.1_Intron|STK25_ENST00000543554.1_5'UTR	NM_001271977.1|NM_001271978.1	NP_001258906.1|NP_001258907.1	O00506	STK25_HUMAN	serine/threonine kinase 25	25	Protein kinase.				response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	10		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		CTTGCCAATGCGGTCGAGCTT	0.622000													21	37					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1465595	1465595	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1465595C>T	ENST00000535453.1	+	14	4008	c.2295C>T	c.(2293-2295)gaC>gaT	p.D765D	APC2_ENST00000233607.2_Silent_p.D765D|C19orf25_ENST00000588427.1_Intron|APC2_ENST00000238483.4_Silent_p.D491D			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	765					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACACCTGGACGGCCTGGCCC	0.716000													3	4					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49050849	49050849	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49050849G>A	ENST00000395474.3	+	2	2252	c.1972G>A	c.(1972-1974)Gtt>Att	p.V658I	WDR6_ENST00000448293.1_Missense_Mutation_p.V577I|WDR6_ENST00000415265.2_Missense_Mutation_p.V76I	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	628					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		TGGGAGCATGGTTATCCTGGG	0.577000													18	18					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242179042	242179042	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:242179042C>T	ENST00000391975.1	-	19	2812	c.2585G>A	c.(2584-2586)cGc>cAc	p.R862H	HDLBP_ENST00000391976.2_Missense_Mutation_p.R862H|HDLBP_ENST00000310931.4_Missense_Mutation_p.R862H|HDLBP_ENST00000427183.2_Missense_Mutation_p.R829H	NM_203346.3	NP_976221.1	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	862	KH 10.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CTCCTGAATGCGTTTCTTGGC	0.602000													38	61					0	0	1	0	0
NKX2-1	7080	broad.mit.edu	37	14	36988568	36988568	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:36988568G>A	ENST00000354822.5	-	2	183	c.85C>T	c.(85-87)Cga>Tga	p.R29*	NKX2-1_ENST00000522719.2_5'UTR|NKX2-1_ENST00000518149.1_5'UTR|RP11-896J10.3_ENST00000521945.1_RNA|NKX2-1-AS1_ENST00000521292.2_RNA|NKX2-1_ENST00000498187.2_5'UTR	NM_001079668.2	NP_001073136.1	P43699	NKX21_HUMAN	NK2 homeobox 1	249					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	7	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		GACATGATTCGGCGGCGGCTG	0.532000			A		NSCLC								4	11					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99640010	99640010	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99640010G>A	ENST00000298819.4	-	13	2127	c.1772C>T	c.(1771-1773)gCg>gTg	p.A591V	CRTAC1_ENST00000370597.3_Silent_p.C605C|CRTAC1_ENST00000370591.2_Silent_p.C605C			Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	0	EGF-like.					proteinaceous extracellular matrix	calcium ion binding	p.C605C(1)		autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		ACTCACCCACGCAGGCTGTGC	0.602000													31	34					0	0	1	0	0
S100PBP	64766	broad.mit.edu	37	1	33292352	33292352	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33292352A>G	ENST00000373475.5	+	3	906	c.652A>G	c.(652-654)Aac>Gac	p.N218D	S100PBP_ENST00000356689.3_3'UTR|S100PBP_ENST00000398243.3_Missense_Mutation_p.N218D|S100PBP_ENST00000373476.1_Missense_Mutation_p.N218D	NM_022753.3	NP_073590.2	Q96BU1	S1PBP_HUMAN	S100P binding protein	218						nucleus	calcium-dependent protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|stomach(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TTCAAACAATAACTTTCAACA	0.438000													25	35					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166797631	166797631	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166797631C>T	ENST00000243344.7	-	6	753	c.616G>A	c.(616-618)Gtg>Atg	p.V206M	AC010127.5_ENST00000440322.1_RNA|AC010127.5_ENST00000443032.1_RNA	NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	206						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						GGAAAATTCACGATTATCTGG	0.428000													18	33					0	0	1	0	0
STAC	6769	broad.mit.edu	37	3	36485034	36485034	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:36485034C>T	ENST00000273183.3	+	2	590	c.290C>T	c.(289-291)gCc>gTc	p.A97V	STAC_ENST00000476388.1_3'UTR|STAC_ENST00000457375.2_Missense_Mutation_p.A97V	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	97					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						TCCACACCCGCCAGGGCTGGT	0.557000													39	46					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821329	5821329	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:5821329C>T	ENST00000381095.3	-	5	2017	c.1390G>A	c.(1390-1392)Ggc>Agc	p.G464S	NLGN4X_ENST00000381092.1_Missense_Mutation_p.G464S|NLGN4X_ENST00000381093.2_Missense_Mutation_p.G484S|NLGN4X_ENST00000275857.6_Missense_Mutation_p.G464S|NLGN4X_ENST00000538097.1_Missense_Mutation_p.G464S	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	464					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						GTGGGGGAGCCGTACTGCGCG	0.612000													8	20					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	32483083	32483083	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:32483083G>A	ENST00000359872.6	-	1	1230	c.469C>T	c.(469-471)Ctg>Ttg	p.L157L		NM_001094.4	NP_001085.2	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	157					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	ACACGGTGCAGGAACTCCAGC	0.577000													42	49					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137721840	137721840	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:137721840C>T	ENST00000371817.3	+	64	5500	c.5086C>T	c.(5086-5088)Ccc>Tcc	p.P1696S		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1696	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CACTTCTTGGCCCAAAGAAAA	0.557000													18	23					0	0	1	0	0
CUL5	8065	broad.mit.edu	37	11	107920642	107920642	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:107920642C>T	ENST00000393094.2	+	4	876	c.260C>T	c.(259-261)aCg>aTg	p.T87M		NM_003478.3	NP_003469.2	Q93034	CUL5_HUMAN	cullin 5	87					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		CAAGATGATACGGCTTTGCTA	0.323000													9	31					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	64005614	64005614	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:64005614T>C	ENST00000443617.2	-	23	4488	c.4401A>G	c.(4399-4401)agA>agG	p.R1467R	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1467					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GTCCTTCTTCTCTTCGCTTCT	0.488000													22	41					0	0	1	0	0
FBXO18	84893	broad.mit.edu	37	10	5955734	5955734	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:5955734C>T	ENST00000379999.5	+	8	1493	c.1389C>T	c.(1387-1389)tgC>tgT	p.C463C	FBXO18_ENST00000362091.4_Silent_p.C412C|FBXO18_ENST00000397269.3_5'UTR|FBXO18_ENST00000379994.1_Silent_p.C149C	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	412					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						TTTTCTATTGCCTATATCTTC	0.393000													30	34					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36682850	36682850	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36682850C>T	ENST00000216181.5	-	35	5205	c.4975G>A	c.(4975-4977)Gcc>Acc	p.A1659T		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1659					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						TCACGAGAGGCGCGGGTGTCA	0.642000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated		OREG0026519	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	63					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56387880	56387880	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56387880C>A	ENST00000355701.3	-	20	4562	c.3692G>T	c.(3691-3693)aGg>aTg	p.R1231M	BZRAP1_ENST00000268893.6_Missense_Mutation_p.R1171M|BZRAP1_ENST00000343736.4_Missense_Mutation_p.R1231M	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1231						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TACCTCAGCCCTGGGCCTCAG	0.627000													12	24					3.07112e-06	3.18879e-06	1	1	0
ARHGEF4	50649	broad.mit.edu	37	2	131799001	131799001	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:131799001G>A	ENST00000392953.3	+	9	1822	c.1303G>A	c.(1303-1305)Gcc>Acc	p.A435T	ARHGEF4_ENST00000409303.1_Missense_Mutation_p.A375T|ARHGEF4_ENST00000355771.3_Missense_Mutation_p.A364T|ARHGEF4_ENST00000525839.1_Missense_Mutation_p.A435T|ARHGEF4_ENST00000428230.2_Intron|ARHGEF4_ENST00000326016.5_Missense_Mutation_p.A435T	NM_032995.1	NP_127462.1	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor (GEF) 4	435	DH.				apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(4)	29		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		TCTGCAGCTGGCCGAGCTGCT	0.612000													10	24					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29001983	29001983	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:29001983G>A	ENST00000282397.4	-	9	1433	c.1182C>T	c.(1180-1182)gaC>gaT	p.D394D	FLT1_ENST00000539099.1_Silent_p.D394D|FLT1_ENST00000541932.1_Silent_p.D394D	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	394	Ig-like C2-type 4.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTTCAGTTACGTCCTTGATAA	0.388000													29	48					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128480708	128480708	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128480708C>T	ENST00000325888.8	+	10	1917	c.1656C>T	c.(1654-1656)ggC>ggT	p.G552G	FLNC_ENST00000346177.6_Silent_p.G552G	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	552					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TCACGTGGGGCGGCTACGCCA	0.642000													36	51					0	0	1	0	0
HADH	3033	broad.mit.edu	37	4	108954379	108954379	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:108954379G>A	ENST00000505878.1	+	8	1042	c.769G>A	c.(769-771)Ggt>Agt	p.G257S	HADH_ENST00000510728.1_3'UTR|HADH_ENST00000603302.1_Missense_Mutation_p.G270S|HADH_ENST00000403312.1_Missense_Mutation_p.G329S|HADH_ENST00000309522.3_Missense_Mutation_p.G253S|HADH_ENST00000454409.2_Missense_Mutation_p.G257S			Q16836	HCDH_HUMAN	hydroxyacyl-CoA dehydrogenase	253					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	15		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)	ATTAGGAGCCGGTTACCCCAT	0.453000													37	41					0	0	1	0	0
PCDHB7	0	broad.mit.edu	37	5	140552434	140552434	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140552434G>A	ENST00000231137.3	+	1	192	c.18G>A	c.(16-18)gaG>gaA	p.E6E		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		6					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCAGAGTGGAGCGTGCTGTGC	0.498000													8	42					0	0	1	0	0
CCPG1	9236	broad.mit.edu	37	15	55669190	55669190	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:55669190G>A	ENST00000310958.6	-	5	709	c.411C>T	c.(409-411)ggC>ggT	p.G137G	CCPG1_ENST00000569205.1_Silent_p.G137G|CCPG1_ENST00000442196.3_Silent_p.G137G|DYX1C1-CCPG1_ENST00000565113.1_RNA|CCPG1_ENST00000425574.3_Silent_p.G137G	NM_001204450.1|NM_001204451.1|NM_004748.4|NM_020739.3	NP_001191379.1|NP_001191380.1|NP_004739.3|NP_065790.2	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1	137	Interaction with MCF2L and SRC (By similarity).				cell cycle	integral to membrane				autonomic_ganglia(1)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|stomach(3)	30				all cancers(107;0.0354)		TAGAGGAAGAGCCCATGTTAA	0.383000													34	42					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125289100	125289100	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:125289100G>A	ENST00000304880.2	-	1	472	c.473C>T	c.(472-474)aCg>aTg	p.T158M		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						CATGAGGAACGTGTGAGTCAG	0.532000													10	11					0	0	1	0	0
GAB1	2549	broad.mit.edu	37	4	144359424	144359424	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:144359424C>A	ENST00000262995.4	+	4	1293	c.866C>A	c.(865-867)aCc>aAc	p.T289N	GAB1_ENST00000262994.4_Missense_Mutation_p.T289N|GAB1_ENST00000505913.1_Missense_Mutation_p.T186N	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	289					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					GTTTTTAATACCCCATCTGGG	0.413000													32	54					1.7881e-09	1.90035e-09	1	1	0
DCAF5	8816	broad.mit.edu	37	14	69558433	69558433	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:69558433T>C	ENST00000341516.5	-	6	984	c.837A>G	c.(835-837)tcA>tcG	p.S279S	DCAF5_ENST00000554215.1_Silent_p.S197S|DCAF5_ENST00000557386.1_Silent_p.S278S|DCAF5_ENST00000553293.1_5'UTR|DCAF5_ENST00000556847.1_Silent_p.S197S|DCAF5_ENST00000389997.6_Silent_p.S279S	NM_003861.2	NP_003852.1	Q96JK2	DCAF5_HUMAN	DDB1 and CUL4 associated factor 5	279						CUL4 RING ubiquitin ligase complex				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|upper_aerodigestive_tract(2)	29						TCATGGTGCATGAGTTGAAGT	0.507000													25	40					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145533300	145533300	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:145533300C>A	ENST00000394434.2	-	12	1393	c.1227G>T	c.(1225-1227)aaG>aaT	p.K409N	LARS_ENST00000510191.1_Missense_Mutation_p.K355N|LARS_ENST00000274562.9_Missense_Mutation_p.K382N|LARS_ENST00000545646.1_Missense_Mutation_p.K363N	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	409	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TACTTACTTGCTTTTTCTTCA	0.428000													11	23					5.16669e-11	5.54509e-11	1	1	0
KRT14	3861	broad.mit.edu	37	17	39739362	39739362	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39739362C>T	ENST00000167586.6	-	7	1391	c.1305G>A	c.(1303-1305)tcG>tcA	p.S435S		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	435	Interaction with Type I keratins and keratin filaments.|Tail.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				TGGATGACTGCGATCCAGAGG	0.592000													20	35					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125528099	125528099	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:125528099C>T	ENST00000241305.3	-	9	1396	c.1242G>A	c.(1240-1242)acG>acA	p.T414T	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	414					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CGTGAATCCGCGTCTCCTCCA	0.632000													18	30					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47735351	47735351	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47735351G>A	ENST00000360380.3	-	15	2934	c.2571C>T	c.(2569-2571)aaC>aaT	p.N857N	STIL_ENST00000243182.6_Silent_p.N857N|STIL_ENST00000337817.5_Silent_p.N857N|STIL_ENST00000371877.3_Silent_p.N857N|STIL_ENST00000396221.2_Silent_p.N857N			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	857					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				CCACAGCAATGTTGCTCTCTT	0.328000													32	36					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74492358	74492358	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74492358G>A	ENST00000394019.2	-	9	832	c.435C>T	c.(433-435)ggC>ggT	p.G145G	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Silent_p.G145G|SLC4A5_ENST00000357822.5_Silent_p.G145G|SLC4A5_ENST00000377632.1_Silent_p.G145G|SLC4A5_ENST00000359484.4_Silent_p.G81G|SLC4A5_ENST00000358683.4_Silent_p.G81G|SLC4A5_ENST00000346834.4_Silent_p.G145G|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377634.4_Silent_p.G145G	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	145						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AGCGTTCGCCGCCTTCCTCTA	0.612000													15	53					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43818078	43818078	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43818078G>A	ENST00000382031.1	+	5	5152	c.5121G>A	c.(5119-5121)aaG>aaA	p.K1707K	MAP1A_ENST00000399453.1_Silent_p.K1469K|MAP1A_ENST00000300231.5_Silent_p.K1469K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1469						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGAAGGACAAGGCCCTGGAAC	0.428000													12	12					0	0	1	0	0
RNF103	7844	broad.mit.edu	37	2	86832362	86832362	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:86832362T>C	ENST00000237455.4	-	4	1630	c.662A>G	c.(661-663)gAa>gGa	p.E221G	AC015971.2_ENST00000439077.1_RNA|AC015971.2_ENST00000426549.1_RNA|AC015971.2_ENST00000424788.1_RNA|RNF103-CHMP3_ENST00000604011.1_Intron|AC015971.2_ENST00000597638.1_RNA|RNF103_ENST00000477307.1_5'UTR|CHMP3_ENST00000439940.2_Intron	NM_001198951.1|NM_005667.3	NP_001185880.1|NP_005658.1	O00237	RN103_HUMAN	ring finger protein 103	221					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(7)|skin(2)	25						TTTCAAGTGTTCAGCATTATA	0.368000													41	59					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98351166	98351166	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:98351166G>A	ENST00000264972.5	+	9	1288	c.1073G>A	c.(1072-1074)cGc>cAc	p.R358H	ZAP70_ENST00000463643.1_3'UTR|ZAP70_ENST00000442208.1_Missense_Mutation_p.R232H|ZAP70_ENST00000451498.2_Missense_Mutation_p.R51H	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	358	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						GGCGTGTACCGCATGCGCAAG	0.637000													17	23					0	0	1	0	0
ZNF101	94039	broad.mit.edu	37	19	19790271	19790271	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19790271G>A	ENST00000592502.1	+	4	583	c.473G>A	c.(472-474)cGg>cAg	p.R158Q	ZNF101_ENST00000415784.2_Missense_Mutation_p.R38Q|ZNF101_ENST00000444249.2_3'UTR			Q8IZC7	ZN101_HUMAN	zinc finger protein 101	158					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)	17						AGTGGTGCACGGCGCACAGTA	0.483000													34	32					0	0	1	0	0
TSSK2	23617	broad.mit.edu	37	22	19119414	19119414	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19119414C>T	ENST00000399635.2	+	1	1094	c.502C>T	c.(502-504)Cgc>Tgc	p.R168C	DGCR14_ENST00000252137.6_3'UTR	NM_053006.4	NP_443732.3	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	168	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(2)|prostate(4)|stomach(1)	11	Colorectal(54;0.0993)					CAGCAATGGGCGCATCATCCT	0.587000													26	40					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370527	35370527	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:35370527G>A	ENST00000373347.1	-	3	726	c.458C>T	c.(457-459)gCg>gTg	p.A153V	DLGAP3_ENST00000235180.4_Missense_Mutation_p.A153V			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	153					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				CGTCCCTGGCGCTGGCCCGGG	0.612000													7	9					0	0	1	0	0
LGALS7B	653499	broad.mit.edu	37	19	39281406	39281406	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39281406C>T	ENST00000314980.4	+	3	189	c.173C>T	c.(172-174)tCg>tTg	p.S58L		NM_001042507.3	NP_001035972.1	P47929	LEG7_HUMAN	lectin, galactoside-binding, soluble, 7B	58	Galectin.				apoptosis|heterophilic cell-cell adhesion	cytoplasm|extracellular space|nucleus	sugar binding	p.S58L(1)									CTGGACACGTCGGAGGTGGTC	0.672000													7	32					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135312833	135312833	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:135312833G>A	ENST00000285968.6	+	34	4932	c.4906G>A	c.(4906-4908)Gcc>Acc	p.A1636T		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1636					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						ATCTAGTATGGCCCAGCACTT	0.502000													40	48					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76928912	76928912	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:76928912C>T	ENST00000380887.2	+	3	494	c.422C>T	c.(421-423)gCc>gTc	p.A141V	ESRRB_ENST00000261532.7_Missense_Mutation_p.A141V|ESRRB_ENST00000507951.1_3'UTR|ESRRB_ENST00000509242.1_Missense_Mutation_p.A141V|ESRRB_ENST00000556177.1_Missense_Mutation_p.A141V			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	141						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		AGCTGCCCGGCCACCAACGAG	0.627000													16	23					0	0	1	0	0
FOXRED2	80020	broad.mit.edu	37	22	36902184	36902184	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36902184G>A	ENST00000397224.4	-	2	379	c.286C>T	c.(286-288)Cgc>Tgc	p.R96C	FOXRED2_ENST00000397223.4_Missense_Mutation_p.R96C|FOXRED2_ENST00000216187.6_Missense_Mutation_p.R96C	NM_001102371.1	NP_001095841.1	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	96					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						CAGTCGTGGCGGAGGTTGAAC	0.647000													19	19					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10791067	10791067	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10791067C>T	ENST00000449870.1	+	9	1222	c.905C>T	c.(904-906)gCt>gTt	p.A302V	ILF3_ENST00000407004.3_Missense_Mutation_p.A302V|ILF3_ENST00000589998.1_Missense_Mutation_p.A302V|ILF3_ENST00000588657.1_Missense_Mutation_p.A302V|ILF3_ENST00000318511.3_Missense_Mutation_p.A302V|ILF3_ENST00000590261.1_Missense_Mutation_p.A302V|ILF3_ENST00000250241.8_Missense_Mutation_p.A302V|ILF3_ENST00000420083.1_Missense_Mutation_p.A302V|ILF3_ENST00000592763.1_Missense_Mutation_p.A302V	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	302	DZF.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GCCACTGATGCTATTGGGCAT	0.468000													11	51					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7635315	7635315	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:7635315A>G	ENST00000359156.4	-	14	3373	c.3171T>C	c.(3169-3171)ctT>ctC	p.L1057L	CD163_ENST00000432237.2_Silent_p.L1057L|CD163_ENST00000541972.1_Silent_p.L1045L|CD163_ENST00000396620.3_Silent_p.L1090L	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	1057					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GAACAACCCCAAGGATCCCGA	0.418000													34	46					0	0	1	0	0
PCDHA1	0	broad.mit.edu	37	5	140166017	140166017	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140166017G>A	ENST00000504120.2	+	1	142	c.142G>A	c.(142-144)Gtt>Att	p.V48I	PCDHA1_ENST00000394633.3_Missense_Mutation_p.V48I|PCDHA1_ENST00000378133.3_Missense_Mutation_p.V48I	NM_018900.2	NP_061723.1												p.V48I(2)		breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTTGGCCGCGTTGCTCAGGA	0.627000													21	32					0	0	1	0	0
MSH3	4437	broad.mit.edu	37	5	80160761	80160761	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:80160761G>T	ENST00000265081.6	+	22	3210	c.3130_splice	c.e22+1	p.G1044_splice		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	1044					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		ACTGGATCCAGGTATGAAATA	0.368000								Mismatch excision repair (MMR)					26	34					1.66031e-10	1.77558e-10	1	1	0
SH3BP4	23677	broad.mit.edu	37	2	235943706	235943706	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:235943706G>T	ENST00000409212.1	+	3	567	c.60G>T	c.(58-60)gaG>gaT	p.E20D	SH3BP4_ENST00000344528.4_Missense_Mutation_p.E20D|SH3BP4_ENST00000392011.2_Missense_Mutation_p.E20D			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	20					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GCAAGTCAGAGGGGACCCTGA	0.557000													14	21					1.49906e-05	1.54943e-05	1	1	0
ZNF134	7693	broad.mit.edu	37	19	58132278	58132278	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58132278A>G	ENST00000396161.5	+	3	1101	c.791A>G	c.(790-792)gAa>gGa	p.E264G		NM_003435.3	NP_003426.3	P52741	ZN134_HUMAN	zinc finger protein 134	264						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(3)|prostate(1)	11		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		AAGTGCAATGAATGTGGGAAA	0.413000													16	68					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55970053	55970053	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:55970053C>T	ENST00000389286.4	-	8	1370	c.1323G>A	c.(1321-1323)agG>agA	p.R441R		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	441	Fibronectin type-III 1.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TATAAAGTGGCCTCTCCCAGG	0.423000													23	30					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133324465	133324465	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:133324465G>A	ENST00000539605.1	-	4	7681	c.997C>T	c.(997-999)Cgt>Tgt	p.R333C	ANKLE2_ENST00000337516.5_Missense_Mutation_p.R395C|ANKLE2_ENST00000357997.5_Missense_Mutation_p.R395C			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	395						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TAACGGATACGCTTCTGCAGC	0.527000													11	34					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	129160405	129160405	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:129160405C>T	ENST00000280333.6	+	33	3407	c.3298C>T	c.(3298-3300)Cgc>Tgc	p.R1100C		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1100					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GACGGAGCTGCGCAAAGCCAC	0.448000													17	23					0	0	1	0	0
PTPRB	0	broad.mit.edu	37	12	70963632	70963632	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:70963632C>T	ENST00000334414.6	-	14	3501	c.3457G>A	c.(3457-3459)Gtt>Att	p.V1153I	PTPRB_ENST00000551525.1_Missense_Mutation_p.V1152I|PTPRB_ENST00000550358.1_Missense_Mutation_p.V1065I|PTPRB_ENST00000550857.1_Missense_Mutation_p.V845I|PTPRB_ENST00000451516.2_Missense_Mutation_p.V845I|PTPRB_ENST00000538708.1_Missense_Mutation_p.V935I|PTPRB_ENST00000261266.5_Missense_Mutation_p.V935I	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	935	Fibronectin type-III 13.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TAGGAATCAACGTCTCCCCCA	0.483000													20	21					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127572213	127572213	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:127572213G>A	ENST00000373580.3	+	8	1481	c.1481G>A	c.(1480-1482)cGc>cAc	p.R494H	OLFML2A_ENST00000288815.5_Missense_Mutation_p.R280H	NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	494	Olfactomedin-like.									endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						CTACGGCAGCGCTTCGTGGCC	0.602000													9	16					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10628675	10628675	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:10628675G>A	ENST00000254958.5	-	13	2168	c.1653C>T	c.(1651-1653)tgC>tgT	p.C551C	JAG1_ENST00000423891.2_Silent_p.C392C	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	551	EGF-like 9.				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						AGTCCTCGGGGCACTTGCAGA	0.562000									Alagille Syndrome				16	26					0	0	1	0	0
CPA2	1358	broad.mit.edu	37	7	129929484	129929484	+	Missense_Mutation	SNP	G	G	A	rs146602328	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:129929484G>A	ENST00000222481.4	+	11	1212	c.1157G>A	c.(1156-1158)cGc>cAc	p.R386H		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	386					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					GACACAGGGCGCTACGGCTTC	0.542000													17	38					0	0	1	0	0
PCDHGA5	0	broad.mit.edu	37	5	140744944	140744944	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140744944C>T	ENST00000518069.1	+	1	1047	c.1047C>T	c.(1045-1047)ctC>ctT	p.L349L	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGTGATCCTCACCTCTCTGA	0.512000													13	19					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7239528	7239528	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:7239528G>A	ENST00000361972.4	-	15	1770	c.1680C>T	c.(1678-1680)tgC>tgT	p.C560C	SFMBT2_ENST00000397167.1_Silent_p.C560C	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	560					regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						GAACCAGCACGCATTTGCCCG	0.483000													6	66					0	0	1	0	0
DTNA	1837	broad.mit.edu	37	18	32400839	32400839	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:32400839C>T	ENST00000283365.9	+	10	1312	c.961C>T	c.(961-963)Cca>Tca	p.P321S	DTNA_ENST00000348997.5_Missense_Mutation_p.P321S|DTNA_ENST00000399113.3_Missense_Mutation_p.P321S|DTNA_ENST00000399097.3_Missense_Mutation_p.P3S|DTNA_ENST00000444659.1_Missense_Mutation_p.P321S|DTNA_ENST00000556414.3_Missense_Mutation_p.P3S|DTNA_ENST00000595022.1_Missense_Mutation_p.P321S|DTNA_ENST00000598774.1_Missense_Mutation_p.P321S|DTNA_ENST00000269192.7_Missense_Mutation_p.P3S|DTNA_ENST00000554864.3_Missense_Mutation_p.P321S|DTNA_ENST00000596745.1_Intron|DTNA_ENST00000315456.6_Missense_Mutation_p.P321S|DTNA_ENST00000269190.7_Missense_Mutation_p.P321S|DTNA_ENST00000591182.1_Missense_Mutation_p.P3S|DTNA_ENST00000598142.1_Missense_Mutation_p.P321S|DTNA_ENST00000597674.1_Missense_Mutation_p.P3S|DTNA_ENST00000269191.6_Missense_Mutation_p.P321S|DTNA_ENST00000598334.1_Missense_Mutation_p.P321S|DTNA_ENST00000601125.1_Missense_Mutation_p.P3S|DTNA_ENST00000599844.1_Missense_Mutation_p.P3S|DTNA_ENST00000597599.1_Missense_Mutation_p.P321S|DTNA_ENST00000399121.5_Missense_Mutation_p.P321S	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	321					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						CCCCATGTTCCCAGATCAGCC	0.493000													26	35					0	0	1	0	0
SELL	6402	broad.mit.edu	37	1	169677595	169677595	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:169677595G>A	ENST00000236147.4	-	3	634	c.474C>T	c.(472-474)gaC>gaT	p.D158D	C1orf112_ENST00000498289.1_Intron|SELL_ENST00000463108.1_5'UTR	NM_000655.4	NP_000646.2	P14151	LYAM1_HUMAN	selectin L	145	EGF-like.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	15	all_hematologic(923;0.208)					TGTGGCAGGCGTCATCGTTCC	0.502000													29	31					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176720970	176720970	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176720970T>C	ENST00000439151.2	+	23	6646	c.6601T>C	c.(6601-6603)Tct>Cct	p.S2201P	NSD1_ENST00000361032.4_Missense_Mutation_p.S2098P|NSD1_ENST00000354179.4_Missense_Mutation_p.S1932P|NSD1_ENST00000347982.4_Missense_Mutation_p.S1932P	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2201					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TGGGCGTCTGTCTTGTACTGA	0.572000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			7	43					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177902750	177902750	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:177902750G>T	ENST00000308284.6	-	21	2682	c.2593C>A	c.(2593-2595)Cga>Aga	p.R865R	RP4-798P15.3_ENST00000354921.2_5'UTR|RP4-798P15.3_ENST00000528461.1_3'UTR|SEC16B_ENST00000495165.1_5'UTR	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	865					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						GAAATACTTCGTGGTCTAGCA	0.468000													14	30					6.31663e-08	6.64488e-08	1	1	0
FAM117B	150864	broad.mit.edu	37	2	203624073	203624073	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:203624073G>A	ENST00000303116.6	+	7	1458	c.716G>A	c.(715-717)tGc>tAc	p.C239Y	FAM117B_ENST00000392238.2_Missense_Mutation_p.C483Y	NM_173511.3	NP_775782.2	Q6P1L5	F117B_HUMAN	family with sequence similarity 117, member B	483										breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)	17						TTTGAGGAATGCTCGTAAGTA	0.423000													15	33					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105923981	105923981	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:105923981T>C	ENST00000357060.3	-	24	3232	c.3117A>G	c.(3115-3117)gcA>gcG	p.A1039A	WDR96_ENST00000428666.1_Silent_p.A1040A	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1039										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CCTTCACGCGTGCAATTTCAA	0.343000													5	29					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72338876	72338876	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:72338876C>T	ENST00000356056.5	-	2	501	c.29G>A	c.(28-30)cGc>cAc	p.R10H	MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000444904.1_Missense_Mutation_p.R10H|MYO9A_ENST00000566885.1_Intron|MYO9A_ENST00000564571.1_Missense_Mutation_p.R10H|MYO9A_ENST00000424560.1_Missense_Mutation_p.R10H	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	10					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						ATCTTCAAAGCGTCGTCTTCC	0.398000													38	59					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2408424	2408424	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2408424G>A	ENST00000332578.3	+	7	811	c.811G>A	c.(811-813)Gtg>Atg	p.V271M		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	271	Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCAGCACCGTGCGGGCCCA	0.647000													19	33					0	0	1	0	0
CD36	948	broad.mit.edu	37	7	80292376	80292376	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:80292376C>T	ENST00000435819.1	+	9	1184	c.500C>T	c.(499-501)tCt>tTt	p.S167F	CD36_ENST00000538969.1_Intron|CD36_ENST00000433696.2_Missense_Mutation_p.S167F|CD36_ENST00000447544.2_Missense_Mutation_p.S167F|CD36_ENST00000309881.7_Missense_Mutation_p.S167F|CD36_ENST00000432207.1_Missense_Mutation_p.S167F|CD36_ENST00000534394.1_Missense_Mutation_p.S91F|CD36_ENST00000544133.1_Missense_Mutation_p.S167F|CD36_ENST00000394788.3_Missense_Mutation_p.S167F			P16671	CD36_HUMAN	CD36 molecule (thrombospondin receptor)	167					cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|large_intestine(1)|lung(6)|ovary(1)	21						AAGTCAAAATCTTCTATGTTC	0.368000													42	57					0	0	1	0	0
OR4K14	122740	broad.mit.edu	37	14	20482668	20482668	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:20482668G>A	ENST00000305045.2	-	1	684	c.685C>T	c.(685-687)Cgt>Tgt	p.R229C		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CCGGCAGCACGCTGTCTGATA	0.498000													5	16					0	0	1	0	0
TMEM134	80194	broad.mit.edu	37	11	67235040	67235040	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67235040G>A	ENST00000393877.3	-	3	318	c.261C>T	c.(259-261)atC>atT	p.I87I	TMEM134_ENST00000308022.2_Silent_p.I87I|TMEM134_ENST00000452789.2_Intron	NM_001078650.1	NP_001072118.1	Q9H6X4	TM134_HUMAN	transmembrane protein 134	87						integral to membrane				endometrium(1)|lung(1)	2						GGGAGCTGCGGATGGAAGTTC	0.647000													14	31					0	0	1	0	0
GPER	0	broad.mit.edu	37	7	1131389	1131389	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:1131389G>A	ENST00000397092.1	+	3	909	c.25G>A	c.(25-27)Ggc>Agc	p.G9S	GPER_ENST00000397088.3_Missense_Mutation_p.G9S|C7orf50_ENST00000397098.3_Intron|GPER_ENST00000401670.1_Missense_Mutation_p.G9S|C7orf50_ENST00000488073.1_Intron|GPER_ENST00000297469.3_Missense_Mutation_p.G9S|C7orf50_ENST00000357429.6_Intron|C7orf50_ENST00000397100.2_Intron	NM_001039966.1	NP_001035055.1	Q99527	GPER_HUMAN		9						endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	13		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		CCAAGCCCGGGGCGTGGGCCT	0.612000													19	42					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38154121	38154121	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:38154121G>T	ENST00000379747.4	-	12	1654	c.1537C>A	c.(1537-1539)Ctc>Atc	p.L513I	POSTN_ENST00000379742.4_Missense_Mutation_p.L513I|POSTN_ENST00000541481.1_Missense_Mutation_p.L513I|POSTN_ENST00000379743.4_Missense_Mutation_p.L513I|POSTN_ENST00000379749.4_Missense_Mutation_p.L513I|POSTN_ENST00000541179.1_Missense_Mutation_p.L513I	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	513	FAS1 4.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		AGTAGGCTGAGGAAGGTGCTA	0.398000													34	48					8.16277e-20	9.0371e-20	1	1	0
NRG1	3084	broad.mit.edu	37	8	32505513	32505513	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:32505513G>A	ENST00000520502.2	+	1	277	c.277G>A	c.(277-279)Gcc>Acc	p.A93T	NRG1_ENST00000287842.3_Intron|NRG1_ENST00000523079.1_Intron|NRG1_ENST00000287845.5_Intron|NRG1_ENST00000341377.5_Intron|NRG1_ENST00000356819.4_Intron|NRG1_ENST00000287840.5_Intron|NRG1_ENST00000405005.2_Intron|NRG1_ENST00000338921.4_Intron|NRG1_ENST00000520407.1_Intron|NRG1_ENST00000521670.1_Intron|NRG1_ENST00000519301.1_Intron	NM_013959.3	NP_039253.1	Q02297	NRG1_HUMAN	neuregulin 1	0	Ig-like C2-type.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CCTCTGCATCGCCGGCCTCAA	0.537000													39	58					0	0	1	0	0
CCDC66	285331	broad.mit.edu	37	3	56647708	56647708	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:56647708G>A	ENST00000394672.3	+	11	1566	c.1496G>A	c.(1495-1497)cGc>cAc	p.R499H	CCDC66_ENST00000326595.7_Missense_Mutation_p.R465H|CCDC66_ENST00000436465.2_Missense_Mutation_p.R499H	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	499										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		GAGGAGCTTCGCTTAGCACAG	0.408000													19	33					0	0	1	0	0
USP14	9097	broad.mit.edu	37	18	179030	179030	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:179030C>T	ENST00000261601.6	+	4	384	c.293C>T	c.(292-294)gCa>gTa	p.A98V	USP14_ENST00000582707.1_Intron|USP14_ENST00000383589.2_Intron|USP14_ENST00000400266.3_Missense_Mutation_p.A87V	NM_005151.3	NP_005142.1	P54578	UBP14_HUMAN	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	98					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(2)	11		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				GAACAGTTAGCATCTGCTGTA	0.408000													27	32					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150324914	150324914	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150324914C>A	ENST00000328902.5	-	3	988	c.772G>T	c.(772-774)Ggc>Tgc	p.G258C	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	258							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCCTCAGAGCCTTGGCCCTGG	0.517000													30	51					9.78306e-22	1.08721e-21	1	1	0
PIP4K2B	8396	broad.mit.edu	37	17	36927471	36927471	+	Missense_Mutation	SNP	C	C	T	rs142813296		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36927471C>T	ENST00000269554.3	-	8	1342	c.862G>A	c.(862-864)Gtg>Atg	p.V288M		NM_003559.4	NP_003550.1	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	288	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)	19						GCCCGGTCCACGTCGTGGATG	0.572000													4	21					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6710187	6710187	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6710187G>T	ENST00000309577.6	-	7	995	c.832C>A	c.(832-834)Cct>Act	p.P278T	CHD4_ENST00000544484.1_Missense_Mutation_p.P275T|CHD4_ENST00000544040.1_Missense_Mutation_p.P271T|CHD4_ENST00000357008.2_Missense_Mutation_p.P278T			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	278					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GGTACACGAGGGCTGCCCTTG	0.473000													62	99					5.01655e-19	5.54669e-19	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141665541	141665541	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:141665541G>T	ENST00000389484.3	-	22	4396	c.3425C>A	c.(3424-3426)cCt>cAt	p.P1142H		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1142	LDL-receptor class A 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTAGCACAAGGATGCTTGGG	0.463000										TSP Lung(27;0.18)			29	34					2.4375e-19	2.69654e-19	1	1	0
SRP14	6727	broad.mit.edu	37	15	40328545	40328545	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40328545C>T	ENST00000267884.6	-	5	471	c.400G>A	c.(400-402)Gca>Aca	p.A134T	SRP14_ENST00000560773.1_Missense_Mutation_p.A54T|SRP14_ENST00000558720.1_Missense_Mutation_p.A54T|SRP14_ENST00000558527.1_5'UTR	NM_003134.4	NP_003125.3	P37108	SRP14_HUMAN	signal recognition particle 14kDa (homologous Alu RNA binding protein)	134	Ala/Thr-rich.				negative regulation of translational elongation|response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|endoplasmic reticulum signal peptide binding|protein binding			endometrium(1)|skin(1)|upper_aerodigestive_tract(1)	3		all_cancers(109;7.56e-18)|all_epithelial(112;4.02e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.84e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0505)		TACTGtgctgctgttgctgct	0.488000													25	29					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116616449	116616449	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:116616449C>T	ENST00000395715.3	-	4	2324	c.1747G>A	c.(1747-1749)Gga>Aga	p.G583R	TRPS1_ENST00000220888.5_Missense_Mutation_p.G570R|TRPS1_ENST00000519674.1_Missense_Mutation_p.G570R|TRPS1_ENST00000520276.1_Missense_Mutation_p.G574R|TRPS1_ENST00000519076.1_Intron	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	570					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTGCAAAGTCCTCTGGGACAG	0.443000									Langer-Giedion syndrome				7	28					0	0	1	0	0
FCHSD1	89848	broad.mit.edu	37	5	141029928	141029928	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:141029928G>A	ENST00000435817.2	-	3	213	c.163C>T	c.(163-165)Cag>Tag	p.Q55*	FCHSD1_ENST00000519800.1_Nonsense_Mutation_p.Q55*|FCHSD1_ENST00000522126.1_5'UTR|FCHSD1_ENST00000522783.1_Nonsense_Mutation_p.Q55*	NM_033449.2	NP_258260.1	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	55	FCH.								FCHSD1/BRAF(2)	central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCATACCTGCCCATACTCC	0.507000													6	44					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123514607	123514607	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:123514607G>A	ENST00000422452.2	-	32	8041	c.7978C>T	c.(7978-7980)Cgc>Tgc	p.R2660C	STAG2_ENST00000469481.1_Intron|TENM1_ENST00000371130.3_Missense_Mutation_p.R2653C	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GCCACTGCGCGCTGTCTGGCA	0.537000													28	13					0	0	1	0	0
ALOX5	240	broad.mit.edu	37	10	45935962	45935962	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:45935962C>T	ENST00000374391.2	+	8	1119	c.1066C>T	c.(1066-1068)Cgt>Tgt	p.R356C	ALOX5_ENST00000542434.1_Missense_Mutation_p.R356C	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	356	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	AATCTGGGTGCGTTCCAGTGA	0.522000													30	40					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45958962	45958962	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:45958962G>A	ENST00000402984.3	+	16	2085	c.1982G>A	c.(1981-1983)gGc>gAc	p.G661D	FBLN1_ENST00000348697.2_Intron|FBLN1_ENST00000327858.6_Intron|FBLN1_ENST00000262722.7_Missense_Mutation_p.G623D|FBLN1_ENST00000442170.2_Intron			P23142	FBLN1_HUMAN	fibulin 1	638					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GCCATCACCGGCGGCAATGAG	0.662000													17	24					0	0	1	0	0
TONSL	4796	broad.mit.edu	37	8	145659037	145659037	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145659037G>A	ENST00000409379.3	-	22	3522	c.3493C>T	c.(3493-3495)Cag>Tag	p.Q1165*		NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	1165					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						CCACACGCCTGCAGGCGCAGG	0.642000													7	51					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78857702	78857702	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78857702C>T	ENST00000306801.3	+	16	2134	c.1772C>T	c.(1771-1773)gCg>gTg	p.A591V	RPTOR_ENST00000575542.1_3'UTR|RPTOR_ENST00000544334.2_Intron	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	591					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						TTCGACTCGGCGAGGTGGTGC	0.647000													6	25					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112337901	112337901	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:112337901G>A	ENST00000206423.3	-	4	3039	c.2086C>T	c.(2086-2088)Cgt>Tgt	p.R696C	CCDC80_ENST00000439685.2_Missense_Mutation_p.R696C	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	696										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						CTGATGAGACGCTGGTCTACC	0.438000													11	49					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45312240	45312240	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:45312240C>T	ENST00000313237.5	-	4	634	c.484G>A	c.(484-486)Gcc>Acc	p.A162T	PHF21B_ENST00000396103.3_Missense_Mutation_p.A162T|PHF21B_ENST00000447824.3_Missense_Mutation_p.A150T|PHF21B_ENST00000403565.1_5'UTR|PHF21B_ENST00000404079.2_Missense_Mutation_p.A150T	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	162							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GGGGCCATGGCGGCGGCATTG	0.687000													4	9					0	0	1	0	0
POU5F2	134187	broad.mit.edu	37	5	93077201	93077201	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:93077201C>T	ENST00000510627.4	-	1	142	c.69G>A	c.(67-69)ggG>ggA	p.G23G	FAM172A_ENST00000395965.3_Intron|FAM172A_ENST00000509739.1_Intron|FAM172A_ENST00000505869.1_Intron|FAM172A_ENST00000509163.1_Intron	NM_153216.1	NP_694948.1	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	23						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity						all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		GGGGCATCGGCCCTCTGGGGC	0.692000													8	12					0	0	1	0	0
NSG1	0	broad.mit.edu	37	4	4411342	4411342	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:4411342G>A	ENST00000421177.2	+	8	2280	c.289G>A	c.(289-291)Gtc>Atc	p.V97I	NSG1_ENST00000397958.1_Missense_Mutation_p.V97I|NSG1_ENST00000504171.1_Missense_Mutation_p.V58I|NSG1_ENST00000513555.1_Missense_Mutation_p.V97I|NSG1_ENST00000506380.1_Missense_Mutation_p.V97I|NSG1_ENST00000433139.2_Missense_Mutation_p.V97I|NSG1_ENST00000505246.1_Missense_Mutation_p.V97I																							CCTCACCTGCGTCGTCTTCCT	0.612000													13	41					0	0	1	0	0
FBXO46	23403	broad.mit.edu	37	19	46216179	46216179	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46216179C>T	ENST00000317683.3	-	2	708	c.575G>A	c.(574-576)cGa>cAa	p.R192Q		NM_001080469.1	NP_001073938.1	Q6PJ61	FBX46_HUMAN	F-box protein 46	192							protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	15		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GGTGGTCGGTCGTGGGTAGCT	0.697000													6	6					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27368073	27368073	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:27368073C>T	ENST00000376087.4	-	7	923	c.758G>A	c.(757-759)gGt>gAt	p.G253D	ANKRD26_ENST00000436985.2_Missense_Mutation_p.G302D|ANKRD26_ENST00000466890.1_5'UTR	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	253						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						ATCATCAACACCCGGTTTGCC	0.338000													28	47					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124285893	124285893	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:124285893C>T	ENST00000409039.3	+	15	2199	c.2174C>T	c.(2173-2175)gCg>gTg	p.A725V		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	725	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTAAACGATGCGGAGTCTGTG	0.458000													7	185					0	0	1	0	0
SAMM50	25813	broad.mit.edu	37	22	44377306	44377306	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:44377306A>G	ENST00000350028.4	+	11	1129	c.972A>G	c.(970-972)gtA>gtG	p.V324V	SAMM50_ENST00000396202.3_Silent_p.V114V	NM_015380.4	NP_056195.3	Q9Y512	SAM50_HUMAN	SAMM50 sorting and assembly machinery component	324					protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial sorting and assembly machinery complex	protein binding			endometrium(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				GAATGTTGGTACCCATTGGTG	0.388000													9	88					0	0	1	0	0
ZNF77	58492	broad.mit.edu	37	19	2933602	2933602	+	Missense_Mutation	SNP	C	C	T	rs139100623		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2933602C>T	ENST00000314531.4	-	4	1615	c.1523G>A	c.(1522-1524)cGt>cAt	p.R508H		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding	p.R508H(1)		breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGTGCACACGAAGGGACGA	0.493000													43	72					0	0	1	0	0
GTPBP10	85865	broad.mit.edu	37	7	90006927	90006927	+	Splice_Site	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:90006927T>A	ENST00000222511.6	+	7	764	c.699_splice	c.e7+1	p.V233_splice	GTPBP10_ENST00000257659.8_Splice_Site_p.V154_splice	NM_033107.3	NP_149098.2	A4D1E9	GTPBA_HUMAN	GTP-binding protein 10 (putative)	233					ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(4)	10						CTACTTTTTGTTGTAAGTCAT	0.303000													40	44					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22804681	22804681	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:22804681G>A	ENST00000361524.3	-	4	3349	c.3201C>T	c.(3199-3201)tgC>tgT	p.C1067C	ZNF521_ENST00000584787.1_Silent_p.C847C|ZNF521_ENST00000538137.2_Silent_p.C1067C	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	1067					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GGCAAGATGCGCACTTATACA	0.498000			T	PAX5	ALL								21	34					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74011183	74011183	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74011183C>T	ENST00000301607.3	-	17	2289	c.2036G>A	c.(2035-2037)cGg>cAg	p.R679Q	EVPL_ENST00000586740.1_Missense_Mutation_p.R701Q	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	679	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CAGCTCCCTCCGCTGGCGCTG	0.692000													15	14					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48613965	48613965	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48613965G>A	ENST00000328333.8	-	68	5833	c.5726C>T	c.(5725-5727)aCg>aTg	p.T1909M	COL7A1_ENST00000454817.1_Missense_Mutation_p.T1877M	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1909	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTTGGGGCCCGTGCCTCCTGG	0.597000													14	6					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126737303	126737303	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:126737303G>A	ENST00000251772.4	+	19	3827	c.3758G>A	c.(3757-3759)cGc>cAc	p.R1253H	PLXNA1_ENST00000393409.2_Missense_Mutation_p.R1276H			Q9UIW2	PLXA1_HUMAN	plexin A1	1276					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		GATGCTGACCGCACACTCAAG	0.632000													15	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438251	179438251	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179438251T>C	ENST00000589042.1	-	326	72832	c.72608A>G	c.(72607-72609)tAt>tGt	p.Y24203C	TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.Y15330C|TTN_ENST00000591111.1_Missense_Mutation_p.Y22562C|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.Y15138C|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.Y21635C|TTN_ENST00000359218.5_Missense_Mutation_p.Y15263C|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22562	Ig-like 121.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCACTCCATATTTATTTAC	0.433000													57	73					0	0	1	0	0
GATA5	140628	broad.mit.edu	37	20	61041509	61041509	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:61041509G>T	ENST00000252997.2	-	4	859	c.798C>A	c.(796-798)gcC>gcA	p.A266A		NM_080473.4	NP_536721.1	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	266					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			AGAGGCCGCAGGCATTGCACA	0.701000													3	2					0.004672	0.00472505	1	1	0
DZIP3	9666	broad.mit.edu	37	3	108363630	108363630	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:108363630T>C	ENST00000361582.3	+	14	1989		c.e14+2		DZIP3_ENST00000463306.1_Splice_Site	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3						protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						ATCAACAAGGTACTAAATGAT	0.418000													16	17					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842294	5842294	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5842294C>T	ENST00000317037.2	+	1	751	c.729C>T	c.(727-729)tgC>tgT	p.C243C	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCAGCACCTGCACATCTCACA	0.413000													32	52					0	0	1	0	0
GSX1	219409	broad.mit.edu	37	13	28367779	28367779	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:28367779G>A	ENST00000302945.2	+	2	537	c.489G>A	c.(487-489)gaG>gaA	p.E163E		NM_145657.1	NP_663632.1	Q9H4S2	GSX1_HUMAN	GS homeobox 1	163					positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)	4		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		TAGAGCTGGAGCGCGAGTTCG	0.572000													18	34					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49693650	49693650	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49693650C>T	ENST00000296452.4	+	5	6775	c.6661C>T	c.(6661-6663)Cgt>Tgt	p.R2221C		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2221					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCCCATGGTGCGTGGTGGCAT	0.587000													12	11					0	0	1	0	0
HSF2BP	11077	broad.mit.edu	37	21	44949656	44949656	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:44949656C>T	ENST00000291560.2	-	9	1314	c.983G>A	c.(982-984)cGc>cAc	p.R328H	HSF2BP_ENST00000542962.1_Missense_Mutation_p.R253H	NM_007031.1	NP_008962.1	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding protein	328					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			kidney(2)|large_intestine(3)|prostate(1)|skin(1)	7				STAD - Stomach adenocarcinoma(101;0.18)		CTCCAGAGTGCGGAGATCTTC	0.587000													12	9					0	0	1	0	0
LAX1	54900	broad.mit.edu	37	1	203743159	203743159	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:203743159G>A	ENST00000442561.2	+	5	937	c.547G>A	c.(547-549)Gca>Aca	p.A183T	LAX1_ENST00000367215.1_3'UTR|LAX1_ENST00000367217.5_Missense_Mutation_p.A167T	NM_017773.3	NP_060243.2	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1	183					B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)|endometrium(3)|large_intestine(2)|lung(13)|prostate(1)|stomach(1)|urinary_tract(2)	24	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CAGAGACTGCGCAAGCATTTC	0.507000													33	39					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39853218	39853218	+	Missense_Mutation	SNP	A	A	G	rs617401		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:39853218A>G	ENST00000564288.1	+	58	15481	c.14704A>G	c.(14704-14706)Atg>Gtg	p.M4902V	MACF1_ENST00000567887.1_Missense_Mutation_p.M4939V|MACF1_ENST00000539005.1_Missense_Mutation_p.M2819V|MACF1_ENST00000372915.3_Missense_Mutation_p.M4907V|MACF1_ENST00000361689.2_Missense_Mutation_p.M2840V|MACF1_ENST00000317713.7_Missense_Mutation_p.M2840V|MACF1_ENST00000289893.4_Missense_Mutation_p.M3342V|MACF1_ENST00000545844.1_Missense_Mutation_p.M2840V			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	4907					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAAGGATTGTATGCAGAAAGC	0.428000													27	42					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25932910	25932910	+	Silent	SNP	G	G	A	rs115227702	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:25932910G>A	ENST00000356865.6	-	16	3342	c.3231C>T	c.(3229-3231)caC>caT	p.H1077H		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1077					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		ACCAATGCCCGTGAAGAATCA	0.488000													37	46					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171556249	171556249	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:171556249C>T	ENST00000367742.3	+	31	8099	c.7857C>T	c.(7855-7857)acC>acT	p.T2619T	PRRC2C_ENST00000338920.4_Silent_p.T2617T|PRRC2C_ENST00000426496.2_Silent_p.T2552T|PRRC2C_ENST00000392078.3_Silent_p.T2619T			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	2617	Gln-rich.						protein C-terminus binding										TACAGCATACCACTCCCCAAG	0.488000													5	8					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48335698	48335698	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:48335698T>C	ENST00000428869.2	-	4	331	c.73A>G	c.(73-75)Aca>Gca	p.T25A	MRO_ENST00000256425.2_Missense_Mutation_p.T25A|MRO_ENST00000436348.2_Intron|MRO_ENST00000587291.1_Intron|MRO_ENST00000398439.3_Missense_Mutation_p.T25A|MRO_ENST00000431965.2_Intron|MRO_ENST00000588444.1_Missense_Mutation_p.T25A			Q9BYG7	MSTRO_HUMAN	maestro	25						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		ATCATTGATGTCCTTTTCTGC	0.413000													11	51					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23830129	23830129	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:23830129G>A	ENST00000264867.2	-	5	770	c.651C>T	c.(649-651)aaC>aaT	p.N217N	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	217					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				GAGGGTCATCGTTTGTGGTCA	0.468000													20	109					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33235718	33235718	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33235718G>A	ENST00000401073.2	+	6	1008	c.938G>A	c.(937-939)cGg>cAg	p.R313Q	KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373481.3_Missense_Mutation_p.R265Q|KIAA1522_ENST00000373480.1_Missense_Mutation_p.R254Q	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	254										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				ACGGGTACCCGGGCCCCACCA	0.677000													16	19					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131916040	131916040	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:131916040T>C	ENST00000286355.5	-	7	3981	c.1889A>G	c.(1888-1890)gAt>gGt	p.D630G	ADCY8_ENST00000377928.3_Missense_Mutation_p.D630G	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	630					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CACGATATTATCAAAGGGCAG	0.502000										HNSCC(32;0.087)			10	22					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211514	38211514	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:38211514G>A	ENST00000379705.3	-	11	3317	c.2460C>T	c.(2458-2460)ggC>ggT	p.G820G	TRPC4_ENST00000355779.2_Intron|TRPC4_ENST00000379681.3_Silent_p.G825G|TRPC4_ENST00000358477.2_Intron|TRPC4_ENST00000447043.1_Intron|TRPC4_ENST00000379679.1_Silent_p.G647G|TRPC4_ENST00000338947.5_Silent_p.G647G|TRPC4_ENST00000379673.2_Intron|TRPC4_ENST00000426868.2_Intron			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	820	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CCAGGGCAGAGCCATTGCTTA	0.428000													22	43					0	0	1	0	0
GPS2	2874	broad.mit.edu	37	17	7217629	7217629	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7217629G>A	ENST00000380728.2	-	4	598	c.298C>T	c.(298-300)Cgg>Tgg	p.R100W	GPS2_ENST00000389167.5_Missense_Mutation_p.R100W|RP11-542C16.2_ENST00000575474.1_3'UTR|GPS2_ENST00000391950.3_Missense_Mutation_p.R100W			Q13227	GPS2_HUMAN	G protein pathway suppressor 2	100					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			breast(1)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(4)	24		Prostate(122;0.157)				TTTCGCCTCCGTTTTTCTTCC	0.458000													40	44					0	0	1	0	0
MPP3	4356	broad.mit.edu	37	17	41908673	41908673	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41908673C>T	ENST00000398393.1	-	3	496	c.236G>A	c.(235-237)cGc>cAc	p.R79H	MPP3_ENST00000398389.4_Missense_Mutation_p.R54H			Q13368	MPP3_HUMAN	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	54	L27 2.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		TTCATAATAGCGAAGCTTCTC	0.552000													6	32					0	0	1	0	0
MCM3	4172	broad.mit.edu	37	6	52141268	52141268	+	Missense_Mutation	SNP	C	C	T	rs146513110		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:52141268C>T	ENST00000596288.1	-	9	1334	c.1307G>A	c.(1306-1308)cGc>cAc	p.R436H	MCM3_ENST00000229854.7_Missense_Mutation_p.R391H|MCM3_ENST00000419835.2_Missense_Mutation_p.R345H|MCM3_ENST00000476448.1_5'UTR	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	391	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					TTCCAGACGGCGCTCTCCTGG	0.498000													5	8					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149482663	149482663	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149482663G>A	ENST00000378016.2	+	0	3079							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GACATTTGACGGACTGGCCTT	0.662000													4	7					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128868309	128868309	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:128868309C>T	ENST00000310343.9	-	11	1057	c.1058G>A	c.(1057-1059)cGt>cAt	p.R353H	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.R4H|ARHGAP32_ENST00000524655.1_Missense_Mutation_p.R279H|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.R4H	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	353					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TTTTGTTGGACGAGACTTCAT	0.408000													27	58					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141461101	141461101	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:141461101G>A	ENST00000389328.4	-	2	680	c.666C>T	c.(664-666)atC>atT	p.I222I	TRAPPC9_ENST00000389327.3_Silent_p.I124I|TRAPPC9_ENST00000438773.2_Silent_p.I124I	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	124					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						GCTGCTCCACGATCTCCCCCT	0.572000													19	31					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71650194	71650194	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:71650194G>A	ENST00000409544.1	+	22	4180	c.3550G>A	c.(3550-3552)Gct>Act	p.A1184T	ZNF638_ENST00000409407.1_Missense_Mutation_p.A124T|ZNF638_ENST00000355812.3_Intron|ZNF638_ENST00000264447.4_Missense_Mutation_p.A1184T	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1184	Glu-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						TGTAGCATCCGCTTCAGTCAG	0.403000													34	36					0	0	1	0	0
SLC39A5	283375	broad.mit.edu	37	12	56630996	56630996	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56630996G>A	ENST00000266980.4	+	10	1644	c.1351G>A	c.(1351-1353)Gtg>Atg	p.V451M	SLC39A5_ENST00000419232.1_3'UTR|SLC39A5_ENST00000454355.2_Missense_Mutation_p.V451M	NM_001135195.1	NP_001128667.1	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (zinc transporter), member 5	451					zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			NS(1)|cervix(6)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GCTGAGCCTCGTGTCTGGAGC	0.642000													27	38					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23855661	23855661	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23855661G>A	ENST00000405093.3	-	33	4892	c.4822C>T	c.(4822-4824)Cgc>Tgc	p.R1608C	MYH6_ENST00000356287.3_Missense_Mutation_p.R1608C	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1608					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TTGCGGCTGCGTGTCTCTGCA	0.617000													4	110					0	0	1	0	0
GGT6	124975	broad.mit.edu	37	17	4461665	4461665	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4461665G>A	ENST00000301395.3	-	3	1090	c.1031C>T	c.(1030-1032)gCa>gTa	p.A344V	GGT6_ENST00000574154.1_Missense_Mutation_p.A376V|GGT6_ENST00000573591.1_Missense_Mutation_p.A228V|GGT6_ENST00000381550.3_Missense_Mutation_p.A382V	NM_153338.2	NP_699169.2	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6	376					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						GGACAGGTGTGCAGAGCCAAA	0.642000													15	26					0	0	1	0	0
POLA2	23649	broad.mit.edu	37	11	65047044	65047044	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65047044C>T	ENST00000265465.3	+	7	1222	c.691C>T	c.(691-693)Ctc>Ttc	p.L231F	POLA2_ENST00000541089.1_Missense_Mutation_p.L23F	NM_002689.2	NP_002680.2	Q14181	DPOA2_HUMAN	polymerase (DNA directed), alpha 2, accessory subunit	231					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding			endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	11					Dacarbazine(DB00851)	TGGCAGCGAACTCAAGGAACA	0.358000													61	69					0	0	1	0	0
SMAD4	4089	broad.mit.edu	37	18	48591850	48591850	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:48591850C>T	ENST00000342988.3	+	9	1551	c.1013C>T	c.(1012-1014)aCa>aTa	p.T338I	SMAD4_ENST00000588745.1_Missense_Mutation_p.T242I|SMAD4_ENST00000398417.2_Missense_Mutation_p.T338I	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	338	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(2)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GTAGGAGAGACATTTAAGGTT	0.433000													17	79					0	0	1	0	0
GJB4	127534	broad.mit.edu	37	1	35227553	35227553	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:35227553C>T	ENST00000339480.1	+	2	1068	c.698C>T	c.(697-699)aCg>aTg	p.T233M	RP1-34M23.5_ENST00000542839.1_RNA	NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	233					cell communication	connexon complex|integral to membrane	gap junction channel activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				CTACCCGATACGTGCCCACCA	0.617000													15	24					0	0	1	0	0
CCDC82	79780	broad.mit.edu	37	11	96117750	96117750	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:96117750C>T	ENST00000278520.5	-	3	590	c.162G>A	c.(160-162)gaG>gaA	p.E54E	CCDC82_ENST00000542662.1_Silent_p.E54E|CCDC82_ENST00000423339.2_Silent_p.E54E			Q8N4S0	CCD82_HUMAN	coiled-coil domain containing 82	54							protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.154)		CACTATCAAGCTCTTCATCAC	0.353000													11	43					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179534361	179534361	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179534361G>A	ENST00000589042.1	-	158	35652	c.35428C>T	c.(35428-35430)Cgt>Tgt	p.R11810C	TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9933	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGCTTCACGAACTTTTTCT	0.333000													39	73					0	0	1	0	0
TIMM50	92609	broad.mit.edu	37	19	39977113	39977113	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39977113A>G	ENST00000314349.4	+	8	1116	c.983A>G	c.(982-984)tAc>tGc	p.Y328C	TIMM50_ENST00000599794.1_Intron|TIMM50_ENST00000607714.1_Missense_Mutation_p.Y225C|TIMM50_ENST00000544017.1_Missense_Mutation_p.Y112C	NM_001001563.1	NP_001001563.1	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)	225					mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			NS(1)|endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)	14	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCCACAAGATACATGGATGGA	0.587000													21	33					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6488405	6488405	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:6488405C>T	ENST00000377828.1	+	2	582	c.414C>T	c.(412-414)ggC>ggT	p.G138G		NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	138					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		CAGACATGGGCGCCCTGCCTA	0.637000													16	27					0	0	1	0	0
ITGB8	3696	broad.mit.edu	37	7	20449610	20449610	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:20449610G>A	ENST00000222573.3	+	14	2984	c.2300G>A	c.(2299-2301)tGc>tAc	p.C767Y	ITGB8_ENST00000537992.1_Missense_Mutation_p.C632Y	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	767					cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						ACTTTCAGGTGCAACTTCTAA	0.338000													5	34					0	0	1	0	0
ADARB1	104	broad.mit.edu	37	21	46624623	46624623	+	Silent	SNP	C	C	A	rs141463450	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:46624623C>A	ENST00000539173.1	+	10	2274	c.1839C>A	c.(1837-1839)ctC>ctA	p.L613L	ADARB1_ENST00000389863.4_Silent_p.L613L|ADARB1_ENST00000360697.3_Silent_p.L613L|ADARB1_ENST00000437626.1_3'UTR|ADARB1_ENST00000348831.4_Silent_p.L573L	NM_015833.3	NP_056648.1	P78563	RED1_HUMAN	adenosine deaminase, RNA-specific, B1	613	A to I editase.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(1)	17				Colorectal(79;0.115)		TGCCACCTCTCTACACCCTCA	0.478000													19	9					1.55795e-14	1.69983e-14	1	1	0
NDUFS3	4722	broad.mit.edu	37	11	47603682	47603682	+	Missense_Mutation	SNP	C	C	T	rs146407178		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:47603682C>T	ENST00000263774.4	+	5	506	c.424C>T	c.(424-426)Cgt>Tgt	p.R142C	NDUFS3_ENST00000533507.1_3'UTR	NM_004551.2	NP_004542.1	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	142					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding	p.R142C(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	CTCACGGATCCGTGTGAAGAC	0.517000													29	43					0	0	1	0	0
TRAV17	0	broad.mit.edu	37	14	22466279	22466279	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22466279G>A	ENST00000390445.2	+	0	356																											ATTTTAATACGTTCAAATGAA	0.408000													12	25					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42196272	42196272	+	Silent	SNP	G	G	A	rs150908395		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:42196272G>A	ENST00000541110.1	-	18	4042	c.3474C>T	c.(3472-3474)ccC>ccT	p.P1158P	TRERF1_ENST00000372922.4_Silent_p.P1138P|TRERF1_ENST00000372917.4_Silent_p.P1067P|TRERF1_ENST00000340840.2_Silent_p.P1067P|TRERF1_ENST00000354325.2_Silent_p.P1055P			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1138	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding	p.P1138P(1)		breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCGCCCCCACGGGCCCCGTAG	0.602000													7	272					0	0	1	0	0
REXO1	57455	broad.mit.edu	37	19	1816553	1816553	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1816553C>T	ENST00000170168.4	-	14	3427	c.3333G>A	c.(3331-3333)acG>acA	p.T1111T		NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	1111	Exonuclease.					nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCAGCCTCCGTCACCCCCG	0.667000													11	25					0	0	1	0	0
BAG6	7917	broad.mit.edu	37	6	31608180	31608180	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31608180C>T	ENST00000404765.2	-	23	3409	c.3120G>A	c.(3118-3120)tgG>tgA	p.W1040*	BAG6_ENST00000375976.4_Nonsense_Mutation_p.W1004*|BAG6_ENST00000362049.6_Nonsense_Mutation_p.W1004*|BAG6_ENST00000211379.5_Nonsense_Mutation_p.W1004*|BAG6_ENST00000439687.2_Intron|BAG6_ENST00000375964.6_Nonsense_Mutation_p.W1010*			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	1010					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						CTGCAGCTGCCCAAGGTTCTG	0.547000													37	53					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127549365	127549365	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:127549365C>T	ENST00000373580.3	+	2	202	c.202C>T	c.(202-204)Cgg>Tgg	p.R68W		NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	68										endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						GCGCAGTGGGCGGGCACGCGT	0.652000													21	25					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11190690	11190690	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11190690T>C	ENST00000361445.4	-	39	5585	c.5509A>G	c.(5509-5511)Act>Gct	p.T1837A	MTOR_ENST00000376838.1_Missense_Mutation_p.T42A	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1837	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						gtggtggcagtggcggccgtg	0.632000													7	13					0	0	1	0	0
KRTAP13-2	337959	broad.mit.edu	37	21	31744251	31744251	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:31744251G>A	ENST00000399889.2	-	1	306	c.281C>T	c.(280-282)aCg>aTg	p.T94M		NM_181621.3	NP_853652.1	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	94	5 X 10 AA approximate repeats.					intermediate filament		p.T94M(1)		endometrium(1)|kidney(1)|lung(14)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	21						AGAGTAAGTCGTCTTGCAAGG	0.617000													3	12					0	0	1	0	0
TMEM38A	79041	broad.mit.edu	37	19	16791335	16791335	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16791335G>A	ENST00000187762.2	+	3	500	c.409G>A	c.(409-411)Gcc>Acc	p.A137T		NM_024074.1	NP_076979.1	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	137	His-rich.					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity	p.A137T(1)		central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)	15						CATCCATCACGCCCATCACCA	0.522000													7	98					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107820829	107820829	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:107820829G>A	ENST00000379028.3	-	25	3159	c.2689C>T	c.(2689-2691)Cgt>Tgt	p.R897C	NRCAM_ENST00000413765.2_Missense_Mutation_p.R878C|NRCAM_ENST00000379022.4_Missense_Mutation_p.R897C|NRCAM_ENST00000425651.2_Missense_Mutation_p.R897C|NRCAM_ENST00000351718.4_Missense_Mutation_p.R881C|NRCAM_ENST00000379024.4_Missense_Mutation_p.R878C			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	897	Fibronectin type-III 3.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						TCAATGTGACGTCTGTTTCTT	0.448000													5	41					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60241838	60241838	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:60241838G>A	ENST00000269499.5	+	13	2942	c.2524G>A	c.(2524-2526)Gca>Aca	p.A842T	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.A521T	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	842					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						CCTGAGCATCGCATCACCAAA	0.507000													47	20					0	0	1	0	0
MAGEA1	4100	broad.mit.edu	37	X	152482197	152482197	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:152482197C>T	ENST00000356661.5	-	3	1032	c.814G>A	c.(814-816)Gct>Act	p.A272T		NM_004988.4	NP_004979.3	P43355	MAGA1_HUMAN	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	272	MAGE.					cytoplasm|plasma membrane				breast(1)|central_nervous_system(7)|kidney(2)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGGTTTCAGCGAGGGCCCTT	0.537000													9	78					0	0	1	0	0
FZD7	8324	broad.mit.edu	37	2	202900064	202900064	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:202900064G>A	ENST00000286201.1	+	1	755	c.694G>A	c.(694-696)Gcc>Acc	p.A232T		NM_003507.1	NP_003498.1	O75084	FZD7_HUMAN	frizzled family receptor 7	232					axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|endometrium(6)|large_intestine(6)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	31						CGATTGTGGCGCCCCGTGCGA	0.682000											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	26					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33927871	33927871	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:33927871C>T	ENST00000389232.4	+	26	3302	c.3232C>T	c.(3232-3234)Cga>Tga	p.R1078*	RYR3_ENST00000415757.3_Nonsense_Mutation_p.R1078*	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1078	4 X approximate repeats.|B30.2/SPRY 2.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCGGGTAGAGCGATCTTATGC	0.517000													6	14					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25276269	25276269	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:25276269A>G	ENST00000216962.4	+	19	2452	c.2342A>G	c.(2341-2343)tAc>tGc	p.Y781C	PYGB_ENST00000471359.1_3'UTR|ABHD12_ENST00000376542.3_Intron	NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	781					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	TATGAAGCCTACATGCAGTGC	0.622000													14	17					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98173004	98173004	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:98173004G>A	ENST00000357947.3	-	8	1218	c.993C>T	c.(991-993)cgC>cgT	p.R331R	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	331	Metalloprotease (By similarity).				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TGAGCCGCACGCGCTGGCCAA	0.532000													4	38					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120744809	120744809	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:120744809C>A	ENST00000527524.2	+	10	1228	c.941C>A	c.(940-942)gCt>gAt	p.A314D	RP11-640N11.2_ENST00000505153.2_RNA|GRIK4_ENST00000438375.2_Missense_Mutation_p.A314D			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	314					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GCTGTCTATGCTGTGGTGACT	0.642000													9	8					2.17888e-05	2.24846e-05	1	1	0
LIMD2	80774	broad.mit.edu	37	17	61775913	61775913	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61775913C>T	ENST00000259006.3	-	5	541	c.383G>A	c.(382-384)tGa>tAa	p.*128*	LIMD2_ENST00000582055.1_Silent_p.*79*|LIMD2_ENST00000578402.1_Silent_p.*128*|LIMD2_ENST00000583211.1_Silent_p.*79*|LIMD2_ENST00000578993.1_Silent_p.*88*|LIMD2_ENST00000578061.1_Silent_p.*128*	NM_030576.3	NP_085053.1	Q9BT23	LIMD2_HUMAN	LIM domain containing 2	0							zinc ion binding			kidney(1)|lung(2)	3						ACAGAGGCCTCAGGCCGTCTT	0.652000													4	10					0	0	1	0	0
STK16	8576	broad.mit.edu	37	2	220112402	220112402	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:220112402T>C	ENST00000409638.3	+	6	752	c.580T>C	c.(580-582)Tgc>Cgc	p.C194R	STK16_ENST00000409260.1_Missense_Mutation_p.C239R|STK16_ENST00000409516.3_Missense_Mutation_p.C76R|STK16_ENST00000409743.1_Intron|STK16_ENST00000396738.2_Missense_Mutation_p.C194R	NM_001008910.2	NP_001008910.1	O75716	STK16_HUMAN	serine/threonine kinase 16	194	Protein kinase.				protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCCCAGCGGTGCACCATCTC	0.577000													9	11					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32029310	32029310	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32029310G>A	ENST00000375244.3	-	21	7557	c.7356C>T	c.(7354-7356)ccC>ccT	p.P2452P	TNXB_ENST00000375247.2_Silent_p.P2452P			P22105	TENX_HUMAN	tenascin XB	2512					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCACCACCTGGGGCCGCCCGT	0.672000													31	37					0	0	1	0	0
DGAT2	84649	broad.mit.edu	37	11	75507443	75507443	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:75507443G>A	ENST00000228027.7	+	5	760	c.500G>A	c.(499-501)gGc>gAc	p.G167D	DGAT2_ENST00000376262.3_Missense_Mutation_p.G124D	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	167					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					GGTATCATGGGCCTGGGTGCC	0.542000													52	83					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29793175	29793175	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:29793175C>T	ENST00000269202.6	+	11	1279	c.1232C>T	c.(1231-1233)tCa>tTa	p.S411L	MEP1B_ENST00000581447.1_Missense_Mutation_p.S411L	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	411	MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TCTGGTGCATCACTGGGTGGT	0.453000													4	56					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136590580	136590580	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:136590580A>G	ENST00000531224.1	-	9	2466	c.2214T>C	c.(2212-2214)gaT>gaC	p.D738D	BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000392348.2_Silent_p.D736D|BCLAF1_ENST00000353331.4_Silent_p.D736D|BCLAF1_ENST00000527759.1_Silent_p.D736D|BCLAF1_ENST00000530767.1_Silent_p.D565D|BCLAF1_ENST00000527536.1_Silent_p.D738D	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	738					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ATTACCTGTCATCTTTGTAAG	0.358000													10	22					0	0	1	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58846467	58846467	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58846467C>T	ENST00000329665.4	+	2	446	c.299C>T	c.(298-300)gCg>gTg	p.A100V		NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	100	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		TTCCTGGGTGCGCTGCCCCCA	0.652000													14	18					0	0	1	0	0
VRK3	51231	broad.mit.edu	37	19	50519379	50519379	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50519379G>A	ENST00000599538.1	-	3	705	c.41C>T	c.(40-42)gCg>gTg	p.A14V	VRK3_ENST00000594948.1_Missense_Mutation_p.A14V|VRK3_ENST00000443401.2_5'UTR|VRK3_ENST00000593919.1_Missense_Mutation_p.A14V|VRK3_ENST00000424804.2_5'UTR|VRK3_ENST00000316763.3_Missense_Mutation_p.A14V|VRK3_ENST00000601912.1_Missense_Mutation_p.A14V|VRK3_ENST00000601341.1_Missense_Mutation_p.A14V|VRK3_ENST00000377011.2_Missense_Mutation_p.A14V|VRK3_ENST00000594092.1_Missense_Mutation_p.A14V			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	14						nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		TTTGAATGCCGCTTGGATACT	0.468000													5	57					0	0	1	0	0
CHDH	55349	broad.mit.edu	37	3	53853045	53853045	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:53853045C>T	ENST00000315251.5	-	8	1723	c.1286G>A	c.(1285-1287)gGc>gAc	p.G429D		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase	429					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	CACACTCGTGCCCCGCATGGG	0.552000													18	37					0	0	1	0	0
MGAT4A	11320	broad.mit.edu	37	2	99279509	99279509	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:99279509C>A	ENST00000393487.1	-	5	850	c.537_splice	c.e5+1	p.E179_splice	MGAT4A_ENST00000461884.1_5'UTR|MGAT4A_ENST00000264968.2_Splice_Site_p.E179_splice|MGAT4A_ENST00000409391.1_Splice_Site_p.E179_splice|MGAT4A_ENST00000414521.2_Splice_Site_p.E51_splice	NM_012214.2	NP_036346.1	Q9UM21	MGT4A_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	179					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	19						AAATAATTACCTCTCCTATGA	0.289000													62	70					5.19286e-32	5.82399e-32	1	1	0
EPPK1	83481	broad.mit.edu	37	8	144945928	144945928	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144945928G>A	ENST00000525985.1	-	2	1565	c.1494C>T	c.(1492-1494)gtC>gtT	p.V498V				P58107	EPIPL_HUMAN	epiplakin 1	498						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCCCCACAGAGACGGTGGCTG	0.677000													10	19					0	0	1	0	0
STX16	8675	broad.mit.edu	37	20	57243061	57243061	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:57243061C>T	ENST00000371141.4	+	4	995	c.271C>T	c.(271-273)Cgg>Tgg	p.R91W	STX16-NPEPL1_ENST00000530122.1_Missense_Mutation_p.R91W|STX16_ENST00000359617.4_Missense_Mutation_p.R38W|STX16_ENST00000358029.4_Missense_Mutation_p.R87W|STX16_ENST00000361830.3_Missense_Mutation_p.R91W|STX16_ENST00000361770.5_Missense_Mutation_p.R74W|STX16_ENST00000496003.1_3'UTR|STX16_ENST00000355957.5_Missense_Mutation_p.R74W|STX16_ENST00000371132.4_Missense_Mutation_p.R70W	NM_001001433.2	NP_001001433.1	O14662	STX16_HUMAN	syntaxin 16	91					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			breast(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(1)	17	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			TGATGTTGGCCGGATTAAGCA	0.468000													12	23					0	0	1	0	0
ZNF23	7571	broad.mit.edu	37	16	71483185	71483185	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:71483185C>T	ENST00000393539.2	-	6	1556	c.743G>A	c.(742-744)gGg>gAg	p.G248E	ZNF23_ENST00000428724.2_Missense_Mutation_p.G190E|ZNF23_ENST00000357254.4_Missense_Mutation_p.G248E|AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000539742.1_5'UTR|ZNF23_ENST00000497160.1_3'UTR|ZNF23_ENST00000358700.2_3'UTR|ZNF23_ENST00000564528.1_Missense_Mutation_p.G190E|ZNF23_ENST00000417828.1_Missense_Mutation_p.G248E|RP11-510M2.10_ENST00000576258.1_RNA	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		GGGCTTCTCCCCACTGTGGAT	0.478000													53	62					0	0	1	0	0
NSUN5	55695	broad.mit.edu	37	7	72718231	72718231	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:72718231G>A	ENST00000428206.1	-	7	829	c.816C>T	c.(814-816)ggC>ggT	p.G272G	NSUN5_ENST00000438747.2_Silent_p.G310G|NSUN5_ENST00000252594.6_Silent_p.G310G|NSUN5_ENST00000310326.8_Silent_p.G310G	NM_001168348.1	NP_001161820.1	Q96P11	NSUN5_HUMAN	NOP2/Sun domain family, member 5	310							methyltransferase activity			breast(1)|endometrium(3)|large_intestine(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	8		Lung NSC(55;0.163)				TCTCACCCGAGCCACTGCAGG	0.567000													8	8					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50584141	50584141	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50584141G>A	ENST00000262794.5	+	19	2612	c.2529G>A	c.(2527-2529)ccG>ccA	p.P843P	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Silent_p.P843P|MOV10L1_ENST00000545383.1_Silent_p.P843P|MOV10L1_ENST00000540615.1_Silent_p.P823P	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	843					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CCGTCAAACCGTATTGCAGAG	0.483000													34	54					0	0	1	0	0
IGLL1	3543	broad.mit.edu	37	22	23915577	23915577	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:23915577T>C	ENST00000330377.2	-	3	635	c.518A>G	c.(517-519)tAc>tGc	p.Y173C	IGLL1_ENST00000249053.3_3'UTR|AP000345.2_ENST00000458318.1_RNA	NM_020070.3	NP_064455.1	P15814	IGLL1_HUMAN	immunoglobulin lambda-like polypeptide 1	173	C region (By similarity to lambda light- chain).|Ig-like C1-type.				immune response	extracellular region|membrane				kidney(1)|large_intestine(1)|lung(5)|skin(4)|stomach(1)	12						GCTGGCCGCGTACTTGTTGTT	0.602000													26	50					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018179	1018179	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1018179C>A	ENST00000398484.2	+	7	1379	c.799C>A	c.(799-801)Cag>Aag	p.Q267K	FGFRL1_ENST00000510644.1_Missense_Mutation_p.Q267K|FGFRL1_ENST00000504138.1_Missense_Mutation_p.Q267K|FGFRL1_ENST00000264748.6_Missense_Mutation_p.Q267K			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	267	Ig-like C2-type 3.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CACGTCCTTCCAGTGCAAGGT	0.677000													19	35					8.10497e-08	8.52441e-08	1	1	0
ZNF101	94039	broad.mit.edu	37	19	19790274	19790274	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19790274G>A	ENST00000592502.1	+	4	586	c.476G>A	c.(475-477)cGc>cAc	p.R159H	ZNF101_ENST00000415784.2_Missense_Mutation_p.R39H|ZNF101_ENST00000444249.2_3'UTR			Q8IZC7	ZN101_HUMAN	zinc finger protein 101	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R159H(2)		breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)	17						GGTGCACGGCGCACAGTAACA	0.478000													33	33					0	0	1	0	0
ZCWPW1	55063	broad.mit.edu	37	7	99998653	99998653	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99998653G>A	ENST00000398027.2	-	18	2178	c.1931C>T	c.(1930-1932)gCg>gTg	p.A644V	ZCWPW1_ENST00000490721.1_Missense_Mutation_p.A473V|ZCWPW1_ENST00000360951.4_3'UTR|ZCWPW1_ENST00000324725.6_Missense_Mutation_p.A473V	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	644							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCCAAACAGCGCCACGGGGAA	0.592000													11	12					0	0	1	0	0
AATK	9625	broad.mit.edu	37	17	79094371	79094371	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79094371C>T	ENST00000326724.4	-	11	3389	c.3365G>A	c.(3364-3366)gGa>gAa	p.G1122E	AATK_ENST00000417379.1_Missense_Mutation_p.G1019E	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	1122	Pro-rich.					integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			TGACAACAGTCCTGGGGGCCC	0.697000													3	4					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144852427	144852427	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:144852427C>T	ENST00000369356.4	-	44	7306	c.7016G>A	c.(7015-7017)cGc>cAc	p.R2339H	PDE4DIP_ENST00000530740.1_3'UTR|PDE4DIP_ENST00000369354.3_3'UTR|PDE4DIP_ENST00000369359.4_3'UTR|PDE4DIP_ENST00000313382.9_3'UTR|PDE4DIP_ENST00000524974.1_5'UTR	NM_001198834.2|NM_014644.4	NP_001185763.2|NP_055459.4	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1950					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTGGTGGCTGCGCTTCTTGCA	0.517000			T	PDGFRB	MPD								6	32					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124857101	124857101	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:124857101G>A	ENST00000356219.3	-	21	2429	c.2274C>T	c.(2272-2274)gcC>gcT	p.A758A	NCOR2_ENST00000404621.1_Silent_p.A740A|NCOR2_ENST00000429285.2_Silent_p.A740A|NCOR2_ENST00000405201.1_Silent_p.A758A|NCOR2_ENST00000404121.2_Silent_p.A311A|NCOR2_ENST00000397355.1_Silent_p.A741A	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	758					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TGTCCTTGGCGGCCTCAGTGT	0.687000													28	35					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3661129	3661129	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3661129G>A	ENST00000263087.4	-	9	989	c.891C>T	c.(889-891)caC>caT	p.H297H		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	297	VWFA.				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		TCCTGGAGCCGTGGCTTGAGG	0.517000													43	61					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890222	55890222	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55890222C>T	ENST00000313472.3	+	1	374	c.374C>T	c.(373-375)gCg>gTg	p.A125V		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					CGCTATGCAGCGATCTGCAGT	0.473000													15	118					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38936264	38936264	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38936264C>A	ENST00000302328.3	-	15	2793	c.2595G>T	c.(2593-2595)caG>caT	p.Q865H	SCN11A_ENST00000444237.2_Missense_Mutation_p.Q865H|SCN11A_ENST00000456224.3_Missense_Mutation_p.Q865H|SCN11A_ENST00000450244.1_Missense_Mutation_p.Q865H	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	865					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCTCTTTTTGCTGTGGTAAGT	0.502000													28	66					5.6714e-07	5.92535e-07	1	1	0
PCNT	5116	broad.mit.edu	37	21	47821621	47821621	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:47821621C>T	ENST00000359568.5	+	26	5055	c.4948C>T	c.(4948-4950)Cgg>Tgg	p.R1650W	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1650					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AGCACTCCTGCGGCGCGAGAG	0.602000													15	8					0	0	1	0	0
LIPI	149998	broad.mit.edu	37	21	15516970	15516970	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:15516970C>T	ENST00000344577.2	-	9	1357	c.1332G>A	c.(1330-1332)atG>atA	p.M444I	LIPI_ENST00000536861.1_Missense_Mutation_p.M423I	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	423			D -> E.		lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		GTGATTTTAACATGAGTCTCT	0.294000													27	14					0	0	1	0	0
GPR157	80045	broad.mit.edu	37	1	9171537	9171537	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:9171537G>A	ENST00000377411.4	-	2	537	c.395C>T	c.(394-396)cCg>cTg	p.P132L	GPR157_ENST00000414642.2_Missense_Mutation_p.P132L	NM_024980.4	NP_079256.4	Q5UAW9	GP157_HUMAN	G protein-coupled receptor 157	132						integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(4)|prostate(1)	5	all_lung(157;0.185)	all_epithelial(116;5.02e-20)|all_lung(118;3.6e-06)|Lung NSC(185;7.93e-06)|Renal(390;0.000147)|Breast(348;0.000688)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.16e-07)|COAD - Colon adenocarcinoma(227;7.73e-05)|Kidney(185;0.000252)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.00178)|BRCA - Breast invasive adenocarcinoma(304;0.00186)|READ - Rectum adenocarcinoma(331;0.0642)		GATGACCAACGGGACCCCCCA	0.617000											OREG0013073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	9					0	0	1	0	0
CYP17A1	1586	broad.mit.edu	37	10	104595136	104595136	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:104595136A>C	ENST00000369887.3	-	2	482	c.311T>G	c.(310-312)aTc>aGc	p.I104S	CYP17A1_ENST00000489268.1_5'UTR	NM_000102.3	NP_000093.1	P05093	CP17A_HUMAN	cytochrome P450, family 17, subfamily A, polypeptide 1	104					androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	GTTGGACGCGATGTCTAGAGT	0.567000											OREG0020487	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	32					0	0	1	0	0
PEX1	5189	broad.mit.edu	37	7	92147233	92147233	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:92147233A>T	ENST00000248633.4	-	5	691	c.596T>A	c.(595-597)cTt>cAt	p.L199H	PEX1_ENST00000428214.1_Missense_Mutation_p.L199H|PEX1_ENST00000438045.1_Intron	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	199					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			ATAACTATGAAGTTTTTTATA	0.383000													17	21					0	0	1	0	0
LHPP	64077	broad.mit.edu	37	10	126177053	126177053	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:126177053G>A	ENST00000368842.5	+	3	404	c.376G>A	c.(376-378)Gca>Aca	p.A126T	LHPP_ENST00000368839.1_Missense_Mutation_p.A126T|LHPP_ENST00000392757.4_Missense_Mutation_p.A126T	NM_022126.3	NP_071409.3	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	126					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity			large_intestine(2)|lung(2)	4		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)		AATTGCAGACGCAGGAGAAAG	0.478000													4	84					0	0	1	0	0
WBP7	0	broad.mit.edu	37	19	36215970	36215970	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36215970C>T	ENST00000222270.7	+	10	3510	c.3510C>T	c.(3508-3510)cgC>cgT	p.R1170R	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Silent_p.R1170R	NM_014727.1	NP_055542.1																					GTGTGCACCGCGTCCGTGTGG	0.572000													16	29					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118771450	118771450	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118771450G>A	ENST00000334801.3	-	6	3966	c.3002C>T	c.(3001-3003)gCg>gTg	p.A1001V	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	1001	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		AGAAGGCACCGCCATGGAAGG	0.642000													26	34					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150901351	150901351	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150901351G>A	ENST00000261800.5	-	18	10815	c.10803C>T	c.(10801-10803)aaC>aaT	p.N3601N		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3601	Cadherin 32.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGACCGTGACGTTGAACGAGT	0.627000													7	17					0	0	1	0	0
AGPS	8540	broad.mit.edu	37	2	178357886	178357886	+	Missense_Mutation	SNP	C	C	T	rs144444120		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:178357886C>T	ENST00000264167.4	+	12	1390	c.1244C>T	c.(1243-1245)cCg>cTg	p.P415L	AGPS_ENST00000409888.1_Intron	NM_003659.3	NP_003650.1	O00116	ADAS_HUMAN	alkylglycerone phosphate synthase	415					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			AGATGTGCTCCGGCATCTATT	0.308000													21	31					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51152950	51152950	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:51152950C>T	ENST00000395542.2	-	8	1268	c.1084G>A	c.(1084-1086)Gct>Act	p.A362T	COBL_ENST00000395540.2_Missense_Mutation_p.A337T|COBL_ENST00000265136.7_Missense_Mutation_p.A337T|COBL_ENST00000441453.1_Missense_Mutation_p.A337T			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	302										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					GGAGGGGGAGCTGGCGCTCGC	0.517000													10	29					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126369942	126369942	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126369942G>T	ENST00000394329.3	+	9	7784	c.7771G>T	c.(7771-7773)Gga>Tga	p.G2591*	FAT4_ENST00000335110.5_Nonsense_Mutation_p.G889*	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2591	Cadherin 25.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CACCATCACAGGATCCTCTTT	0.423000													4	27					0.150653	0.151081	1	1	0
MTMR12	54545	broad.mit.edu	37	5	32230195	32230195	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:32230195G>A	ENST00000382142.3	-	16	2103	c.1933C>T	c.(1933-1935)Cgt>Tgt	p.R645C	MTMR12_ENST00000510216.1_5'UTR|MTMR12_ENST00000280285.5_Missense_Mutation_p.R591C|MTMR12_ENST00000264934.5_Missense_Mutation_p.R535C	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	645						cytoplasm	phosphatase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GGAATCCAACGTAGGTAGCGC	0.502000													69	89					0	0	1	0	0
VEPH1	79674	broad.mit.edu	37	3	156983435	156983435	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:156983435G>A	ENST00000362010.2	-	13	2452	c.2145C>T	c.(2143-2145)ggC>ggT	p.G715G	RP11-550I24.2_ENST00000475102.1_RNA|VEPH1_ENST00000543418.1_Silent_p.G670G|VEPH1_ENST00000392832.2_Silent_p.G715G|RP11-550I24.2_ENST00000488040.1_RNA|RP11-550I24.2_ENST00000487238.1_RNA|VEPH1_ENST00000392833.2_Silent_p.G670G	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	715						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TGAGAGGCTGGCCATCTTGAT	0.378000													28	64					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16893830	16893830	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16893830G>A	ENST00000432949.1	-	8	892	c.893C>T	c.(892-894)gCt>gTt	p.A298V	NBPF1_ENST00000420031.2_3'UTR|NBPF1_ENST00000430580.2_Silent_p.L895L			Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	0						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TTCTCATCCAGCAGCTCCCTG	0.483000													15	2261					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1226491	1226491	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1226491C>T	ENST00000326873.7	+	9	2320	c.1147C>T	c.(1147-1149)Cgc>Tgc	p.R383C		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	383					anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CAATGGACAGCGCCGGGGCCT	0.687000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			5	14					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51918880	51918880	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:51918880C>A	ENST00000371117.3	-	20	2195	c.1920G>T	c.(1918-1920)aaG>aaT	p.K640N	PKHD1_ENST00000340994.4_Missense_Mutation_p.K640N	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	640					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.K640N(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AGGTGGTATTCTTTACCATGT	0.493000													22	25					2.89027e-11	3.10618e-11	1	1	0
TNPO1	3842	broad.mit.edu	37	5	72183988	72183988	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:72183988C>T	ENST00000337273.5	+	13	1813	c.1387C>T	c.(1387-1389)Cgt>Tgt	p.R463C	TNPO1_ENST00000506351.2_Missense_Mutation_p.R455C|TNPO1_ENST00000523768.1_Missense_Mutation_p.R413C|TNPO1_ENST00000454282.1_Missense_Mutation_p.R413C	NM_002270.3	NP_002261.3	Q92973	TNPO1_HUMAN	transportin 1	463					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		GGCTCTTGTGCGTTCCATAAC	0.463000													16	37					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43078550	43078550	+	RNA	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:43078550A>G	ENST00000486187.1	-	0	432							Q06732	ZN33B_HUMAN	zinc finger protein 33B							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						GTCCAGGATCAGTGCATGAAC	0.512000													11	16					0	0	1	0	0
ARSI	340075	broad.mit.edu	37	5	149677669	149677669	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149677669G>A	ENST00000328668.7	-	2	1397	c.818C>T	c.(817-819)gCt>gTt	p.A273V		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	273						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTGCGCACAGCCTCATCCAT	0.597000													6	17					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52557342	52557342	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52557342C>A	ENST00000321725.6	+	64	7201	c.7125C>A	c.(7123-7125)ggC>ggA	p.G2375G		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	2375	FAS1 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TCAATGAAGGCTTTGTGGACA	0.562000													32	65					2.42023e-17	2.66278e-17	1	1	0
CACNG4	27092	broad.mit.edu	37	17	65021029	65021029	+	Silent	SNP	C	C	T	rs139336374	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:65021029C>T	ENST00000262138.3	+	3	360	c.358C>T	c.(358-360)Ctg>Ttg	p.L120L		NM_014405.3	NP_055220.1	Q9UBN1	CCG4_HUMAN	calcium channel, voltage-dependent, gamma subunit 4	120					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(3)	19	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			CCTGCTCCTGCTGGGTGGCCT	0.652000													29	31					0	0	1	0	0
VPS52	6293	broad.mit.edu	37	6	33236399	33236399	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33236399C>A	ENST00000445902.2	-	7	794	c.576G>T	c.(574-576)gaG>gaT	p.E192D	VPS52_ENST00000436044.2_Missense_Mutation_p.E67D|VPS52_ENST00000482399.1_3'UTR|VPS52_ENST00000478934.1_5'UTR	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	192					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						AGAACCTGGGCTCTGTCACTG	0.592000													17	17					2.35188e-11	2.53156e-11	1	1	0
NXPE1	120400	broad.mit.edu	37	11	114393111	114393111	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:114393111A>G	ENST00000536271.1	-	4	1614	c.371T>C	c.(370-372)tTc>tCc	p.F124S	NXPE1_ENST00000424269.1_Missense_Mutation_p.F408S|NXPE1_ENST00000251921.2_Missense_Mutation_p.F266S					neurexophilin and PC-esterase domain family, member 1																		GTAGAGCTGGAAAGTGACGAA	0.423000													9	68					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65095157	65095157	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:65095157C>T	ENST00000371073.2	+	5	637	c.637C>T	c.(637-639)Cgc>Tgc	p.R213C	CACHD1_ENST00000495994.1_3'UTR|CACHD1_ENST00000290039.5_Missense_Mutation_p.R162C			Q5VU97	CAHD1_HUMAN	cache domain containing 1	213					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						CTACGAACACCGCAGTAGGTA	0.388000													30	48					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1634265	1634265	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1634265G>A	ENST00000426508.2	-	11	1675	c.1312C>T	c.(1312-1314)Cac>Tac	p.H438Y	LA16c-395F10.2_ENST00000563162.1_RNA|IFT140_ENST00000439987.2_5'UTR	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	438										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				CGCAGGCTGTGTGCGACCCCC	0.627000													10	9					0	0	1	0	0
IGHG4	0	broad.mit.edu	37	14	106090913	106090913	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:106090913C>T	ENST00000390543.2	-	0	883																											CTGCCACCTGCTCTTGTCCAC	0.572000													57	80					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109795355	109795355	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109795355C>T	ENST00000271332.3	+	1	2715	c.2654C>T	c.(2653-2655)gCc>gTc	p.A885V		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	885	Cadherin 7.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GAGAACGTGGCCCAGTATGTC	0.557000													14	28					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3639505	3639505	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3639505C>T	ENST00000294008.3	-	12	4774	c.4134G>A	c.(4132-4134)ccG>ccA	p.P1378P		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1378	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						TTGGCCCAGGCGGCGAGTGTT	0.657000								Direct reversal of damage					4	49					0	0	1	0	0
FBXL16	146330	broad.mit.edu	37	16	747093	747093	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:747093G>A	ENST00000397621.1	-	2	644	c.313C>T	c.(313-315)Ctc>Ttc	p.L105F	FBXL16_ENST00000324361.5_Missense_Mutation_p.L105F	NM_153350.3	NP_699181.2	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	105	F-box.									endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)	10		Hepatocellular(780;0.0218)				TACCAGAAGAGCCCATTGAGG	0.682000													7	17					0	0	1	0	0
CYP26B1	56603	broad.mit.edu	37	2	72359683	72359683	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:72359683G>A	ENST00000001146.2	-	6	1415	c.1212C>T	c.(1210-1212)ccC>ccT	p.P404P	CYP26B1_ENST00000412253.1_Silent_p.P213P|CYP26B1_ENST00000546307.1_Silent_p.P329P	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	404					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						CTTTGAACACGGGCGCTGTGT	0.612000													3	13					0	0	1	0	0
GCDH	2639	broad.mit.edu	37	19	13007110	13007110	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13007110C>T	ENST00000222214.5	+	8	938	c.727C>T	c.(727-729)Cgg>Tgg	p.R243W	GCDH_ENST00000591470.1_Missense_Mutation_p.R243W|GCDH_ENST00000457854.1_Missense_Mutation_p.R243W|GCDH_ENST00000422947.2_Missense_Mutation_p.R199W			Q92947	GCDH_HUMAN	glutaryl-CoA dehydrogenase	243					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)	19						GAAGGGGATGCGGGGTCTCTC	0.607000													16	42					0	0	1	0	0
PPP1R3F	89801	broad.mit.edu	37	X	49142941	49142941	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:49142941G>A	ENST00000055335.6	+	4	1805	c.1789G>A	c.(1789-1791)Gaa>Aaa	p.E597K	PPP1R3F_ENST00000438316.1_Missense_Mutation_p.E268K|PPP1R3F_ENST00000495799.1_Missense_Mutation_p.E251K|PPP1R3F_ENST00000376188.1_Missense_Mutation_p.E251K|PPP1R3F_ENST00000466508.1_Missense_Mutation_p.E251K	NM_033215.4	NP_149992.3	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory subunit 3F	597						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(4)	27	Ovarian(276;0.236)					CAGCCCCAAGGAATCGCCTCC	0.617000													8	0					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131671496	131671496	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131671496C>T	ENST00000259324.5	+	3	2576	c.2053C>T	c.(2053-2055)Cgc>Tgc	p.R685C	LRRC8A_ENST00000372600.4_Missense_Mutation_p.R685C|LRRC8A_ENST00000372599.3_Missense_Mutation_p.R685C	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	685					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						CTTCTACTGCCGCAAGCTGCG	0.597000													5	25					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133403069	133403069	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:133403069G>A	ENST00000329321.3	+	2	1721	c.1252G>A	c.(1252-1254)Gag>Aag	p.E418K	GPR39_ENST00000470071.1_3'UTR|LYPD1_ENST00000397463.2_3'UTR	NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	418						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GAGCGAGGCCGAGCCCCAGTC	0.562000													20	24					0	0	1	0	0
HSPA13	6782	broad.mit.edu	37	21	15746111	15746111	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:15746111G>A	ENST00000285667.3	-	5	1310	c.1243C>T	c.(1243-1245)Cgt>Tgt	p.R415C	HSPA13_ENST00000544452.1_Missense_Mutation_p.R207C	NM_006948.4	NP_008879.3	P48723	HSP13_HUMAN	heat shock protein 70kDa family, member 13	415						endoplasmic reticulum|microsome	ATP binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						ATGACTTGACGGATCCGAGGA	0.478000													31	18					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33018260	33018260	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:33018260C>T	ENST00000375030.2	+	13	1343	c.724_splice	c.e13-1	p.T242_splice	C10orf68_ENST00000375025.4_Splice_Site_p.T234_splice|C10orf68_ENST00000375028.3_Splice_Site_p.T210_splice			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	234										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						TTCTATTTAGCGTTTCCTTTA	0.313000													18	38					0	0	1	0	0
RHOBTB2	23221	broad.mit.edu	37	8	22862091	22862091	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22862091G>A	ENST00000251822.6	+	2	681	c.144G>A	c.(142-144)acG>acA	p.T48T	RHOBTB2_ENST00000519685.1_Silent_p.T70T|RHOBTB2_ENST00000522948.1_Silent_p.T55T|RHOBTB2_ENST00000523918.1_3'UTR|RP11-875O11.1_ENST00000523884.1_RNA	NM_015178.2	NP_055993.2	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2	48	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	31		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		TGCTGGCCACGCATGTGCCCA	0.617000											OREG0018628	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	15					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21110052	21110052	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:21110052C>A	ENST00000261383.3	-	17	2404	c.2405G>T	c.(2404-2406)aGa>aTa	p.R802I	DNAH3_ENST00000415178.1_Missense_Mutation_p.R802I	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	802	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTCCAGTTCTCTGTGGTAGCC	0.403000													51	99					7.92265e-33	8.89139e-33	1	1	0
MOSPD3	64598	broad.mit.edu	37	7	100212493	100212493	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100212493C>T	ENST00000393950.2	+	4	797	c.515C>T	c.(514-516)cCc>cTc	p.P172L	MOSPD3_ENST00000424091.2_Missense_Mutation_p.P162L|MOSPD3_ENST00000379527.2_Missense_Mutation_p.P172L|MOSPD3_ENST00000223054.4_Missense_Mutation_p.P172L	NM_023948.4	NP_076438.1	O75425	MSPD3_HUMAN	motile sperm domain containing 3	172						integral to membrane	structural molecule activity			breast(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TTCTCAGACCCCCGCCAGCAA	0.587000													11	19					0	0	1	0	0
MED14	9282	broad.mit.edu	37	X	40556412	40556412	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:40556412C>T	ENST00000324817.1	-	13	1632	c.1514G>A	c.(1513-1515)tGc>tAc	p.C505Y		NM_004229.3	NP_004220.2	O60244	MED14_HUMAN	mediator complex subunit 14	505	Interaction with SREBF1.|Interaction with STAT2.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(2)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AGACTGCTTGCAACGCTGTTG	0.363000													24	5					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24208809	24208809	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:24208809G>A	ENST00000265769.4	+	20	2274	c.2164G>A	c.(2164-2166)Gtt>Att	p.V722I	RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000397649.3_Missense_Mutation_p.C470Y|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	722					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		GGTAAAGGCTGTTCAACCCCA	0.453000													18	27					0	0	1	0	0
SRM	6723	broad.mit.edu	37	1	11115092	11115092	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11115092G>A	ENST00000376957.2	-	7	895	c.815C>T	c.(814-816)gCg>gTg	p.A272V		NM_003132.2	NP_003123.2	P19623	SPEE_HUMAN	spermidine synthase	272					spermidine biosynthetic process	cytosol	protein homodimerization activity|spermidine synthase activity			large_intestine(1)|lung(1)|urinary_tract(1)	3	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.228)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)	S-Adenosylmethionine(DB00118)|Spermine(DB00127)	CTGCATCTGCGCCACCTGCTG	0.632000													22	68					0	0	1	0	0
ULK2	9706	broad.mit.edu	37	17	19750061	19750061	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:19750061C>T	ENST00000395544.4	-	6	957	c.458G>A	c.(457-459)cGc>cAc	p.R153H	ULK2_ENST00000361658.2_Missense_Mutation_p.R153H	NM_014683.3	NP_055498.3	Q8IYT8	ULK2_HUMAN	unc-51 like autophagy activating kinase 2	153	Protein kinase.				signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					TATTTTGATGCGAATACCACT	0.373000													66	96					0	0	1	0	0
PRPF4	9128	broad.mit.edu	37	9	116045694	116045694	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:116045694C>T	ENST00000374199.4	+	6	987	c.586C>T	c.(586-588)Cga>Tga	p.R196*	PRPF4_ENST00000374198.4_Nonsense_Mutation_p.R197*			O43172	PRP4_HUMAN	pre-mRNA processing factor 4	197						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding	p.R197*(1)		NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	23						GGAAGAGGCCCGACTCCATAA	0.522000													8	33					0	0	1	0	0
TBX10	347853	broad.mit.edu	37	11	67400480	67400480	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67400480A>G	ENST00000335385.3	-	5	731	c.644T>C	c.(643-645)tTc>tCc	p.F215S		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	215					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						GAAGGACTTGAAGTTCTCCTG	0.572000													49	73					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12903784	12903784	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:12903784G>T	ENST00000380659.3	+	3	296	c.157G>T	c.(157-159)Gac>Tac	p.D53Y		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	53					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	GGACTGCACAGACAAGCATTT	0.483000													24	50					1.66031e-10	1.77558e-10	1	1	0
ALDH1L2	160428	broad.mit.edu	37	12	105462663	105462663	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:105462663C>A	ENST00000258494.9	-	4	569		c.e4-1		ALDH1L2_ENST00000424857.2_Splice_Site	NM_001034173.3	NP_001029345.2	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2						10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|prostate(2)|skin(3)|stomach(2)	35						AATTAGAGTCCTGTGAAAAGA	0.333000													14	24					2.61681e-11	2.81437e-11	1	1	0
DNAH2	146754	broad.mit.edu	37	17	7691263	7691263	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7691263C>T	ENST00000572933.1	+	43	8149	c.6689C>T	c.(6688-6690)gCt>gTt	p.A2230V	DNAH2_ENST00000389173.2_Missense_Mutation_p.A2230V			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2230	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACTGACTACGCTGACCTGGGC	0.552000													19	20					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39874303	39874303	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:39874303A>G	ENST00000308559.7	-	10	1826	c.1693T>C	c.(1693-1695)Tgc>Cgc	p.C565R	MOCS1_ENST00000425303.2_Missense_Mutation_p.C581R|MOCS1_ENST00000373186.4_3'UTR|MOCS1_ENST00000373188.2_3'UTR|MOCS1_ENST00000373175.4_3'UTR|MOCS1_ENST00000340692.5_Missense_Mutation_p.C581R|MOCS1_ENST00000373195.3_Missense_Mutation_p.C478R			Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	581	Molybdenum cofactor biosynthesis protein C.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					CGAGCCCGGCAAGATGCCTGG	0.657000													21	34					0	0	1	0	0
AKT2	208	broad.mit.edu	37	19	40762906	40762906	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:40762906G>T	ENST00000392038.2	-	3	400	c.102C>A	c.(100-102)tcC>tcA	p.S34S	AKT2_ENST00000424901.1_Silent_p.S34S|AKT2_ENST00000579047.1_5'UTR|AKT2_ENST00000311278.6_Silent_p.S34S	NM_001243027.1|NM_001243028.1|NM_001626.4	NP_001229956.1|NP_001229957.1|NP_001617.1	P31751	AKT2_HUMAN	v-akt murine thymoma viral oncogene homolog 2	34	PH.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(3)|large_intestine(9)|lung(10)|prostate(2)|skin(1)	27			Lung(22;0.000499)			ACCCAATGAAGGAGCCGTCGC	0.552000			A		"""ovarian, pancreatic """								16	25					1.02788e-11	1.10723e-11	1	1	0
ZC3H4	23211	broad.mit.edu	37	19	47570545	47570545	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47570545C>T	ENST00000253048.5	-	15	3017	c.2980G>A	c.(2980-2982)Gca>Aca	p.A994T	ZC3H4_ENST00000594019.1_5'UTR	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	994							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGGGGCACTGCGTCCTGCTTG	0.716000													35	33					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47955158	47955158	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:47955158A>G	ENST00000289672.2	-	8	1149	c.1099T>C	c.(1099-1101)Tcc>Ccc	p.S367P		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	367					cell-cell adhesion	integral to membrane		p.S367P(1)	BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TTGTAGGTGGACATAtccaac	0.333000													10	44					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71577014	71577014	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:71577014C>T	ENST00000409544.1	+	2	1560	c.930C>T	c.(928-930)tcC>tcT	p.S310S	ZNF638_ENST00000355812.3_Silent_p.S310S|ZNF638_ENST00000410075.1_3'UTR|ZNF638_ENST00000377802.2_Silent_p.S310S|ZNF638_ENST00000264447.4_Silent_p.S310S	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	310					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						CCATAAAATCCGTCAACCAAT	0.418000													27	52					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287631	202287631	+	Missense_Mutation	SNP	G	G	A	rs147534207	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:202287631G>A	ENST00000367278.3	+	18	2289	c.2200G>A	c.(2200-2202)Gtg>Atg	p.V734M	LGR6_ENST00000439764.2_Missense_Mutation_p.V595M|LGR6_ENST00000255432.7_Missense_Mutation_p.V682M	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	734						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						GGGCTTCACCGTGGCCCTGGT	0.657000													10	18					0	0	1	0	0
MLXIPL	51085	broad.mit.edu	37	7	73010560	73010560	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:73010560G>A	ENST00000313375.3	-	13	2028	c.1981C>T	c.(1981-1983)Cgg>Tgg	p.R661W	MLXIPL_ENST00000395189.1_Missense_Mutation_p.R568W|MLXIPL_ENST00000429400.2_Missense_Mutation_p.R661W|MLXIPL_ENST00000354613.1_Missense_Mutation_p.R659W|MLXIPL_ENST00000434326.1_Missense_Mutation_p.R567W|MLXIPL_ENST00000414749.2_Missense_Mutation_p.R659W	NM_032951.2|NM_032953.2	NP_116569.1|NP_116571.1	Q9NP71	WBS14_HUMAN	MLX interacting protein-like	661					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			cervix(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13		Lung NSC(55;0.0659)|all_lung(88;0.152)				TTGAAGCGCCGCTTCTGCTCC	0.647000													32	61					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95730639	95730639	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:95730639G>A	ENST00000311106.3	-	13	2050	c.1813C>T	c.(1813-1815)Cgt>Tgt	p.R605C	PCSK1_ENST00000508626.1_Missense_Mutation_p.R558C|CTD-2337A12.1_ENST00000502645.2_RNA|PCSK1_ENST00000513085.1_5'UTR	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	605					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GTGTACACACGAGGCTGCTTC	0.478000													40	58					0	0	1	0	0
PPIE	10450	broad.mit.edu	37	1	40209539	40209539	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:40209539G>A	ENST00000324379.5	+	6	346	c.327G>A	c.(325-327)acG>acA	p.T109T	PPIE_ENST00000372830.1_Silent_p.T109T|PPIE_ENST00000470213.1_Silent_p.T109T|PPIE_ENST00000480169.1_3'UTR|PPIE_ENST00000356511.2_Silent_p.T109T	NM_006112.3	NP_006103.1	Q9UNP9	PPIE_HUMAN	peptidylprolyl isomerase E (cyclophilin E)	109					protein folding|regulation of transcription, DNA-dependent	catalytic step 2 spliceosome	cyclosporin A binding|nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|RNA binding			kidney(3)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	9	all_cancers(7;1.63e-13)|all_lung(5;2.27e-16)|all_epithelial(6;1.35e-15)|Lung NSC(20;1.49e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;2.7e-17)|all cancers(16;5.5e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CTGGGAAGACGCTTGAAGAGA	0.468000													9	7					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75980589	75980589	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75980589C>T	ENST00000308508.5	-	3	2909	c.2817G>A	c.(2815-2817)cgG>cgA	p.R939R		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	939	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						CATGGCGGGGCCGCTCCATGA	0.587000													9	60					0	0	1	0	0
PTPN7	5778	broad.mit.edu	37	1	202124675	202124675	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:202124675C>T	ENST00000309017.3	-	5	1542	c.769G>A	c.(769-771)Gcc>Acc	p.A257T	PTPN7_ENST00000492977.1_5'UTR|PTPN7_ENST00000367279.4_Missense_Mutation_p.A191T|PTPN7_ENST00000544762.1_Intron|PTPN7_ENST00000308986.5_Missense_Mutation_p.A152T|PTPN7_ENST00000543735.1_5'UTR	NM_001199797.1|NM_002832.3	NP_001186726.1|NP_002823.3	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type 7	152	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|soft_tissue(1)|urinary_tract(1)	13						ATGTAGTTGGCATTGATGTAA	0.547000													13	29					0	0	1	0	0
SLC25A35	399512	broad.mit.edu	37	17	8195891	8195891	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8195891G>A	ENST00000380067.2	-	2	435	c.391C>T	c.(391-393)Cag>Tag	p.Q131*	SLC25A35_ENST00000580340.1_Nonsense_Mutation_p.Q131*|SLC25A35_ENST00000396278.1_Nonsense_Mutation_p.Q131*|SLC25A35_ENST00000577745.1_Nonsense_Mutation_p.Q131*|SLC25A35_ENST00000579192.1_Nonsense_Mutation_p.Q131*	NM_201520.1	NP_958928.1	Q3KQZ1	S2535_HUMAN	solute carrier family 25, member 35	131					transport	integral to membrane|mitochondrial inner membrane				breast(2)|large_intestine(2)|lung(2)	6						GCCTGTGCCTGCAGGTGTGTC	0.527000													14	62					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163280016	163280016	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:163280016C>T	ENST00000332142.5	-	9	2083	c.1984G>A	c.(1984-1986)Gta>Ata	p.V662I	KCNH7_ENST00000328032.4_Missense_Mutation_p.V655I	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	662					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	ATTGCAGATACATTCCCAAAA	0.403000													24	45					0	0	1	0	0
SGPL1	8879	broad.mit.edu	37	10	72636336	72636336	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:72636336G>A	ENST00000373202.3	+	14	1684	c.1484G>A	c.(1483-1485)cGa>cAa	p.R495Q		NM_003901.3	NP_003892.2	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	495					apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity			large_intestine(4)	4					Pyridoxal Phosphate(DB00114)	GCCCGGAAACGAGTAGCTATA	0.393000													32	51					0	0	1	0	0
SLC27A5	10998	broad.mit.edu	37	19	59012676	59012676	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:59012676G>A	ENST00000263093.2	-	4	1268	c.1159C>T	c.(1159-1161)Cgg>Tgg	p.R387W	SLC27A5_ENST00000601355.1_Missense_Mutation_p.R303W	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	387					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CACAAGTACCGCAGGAGCTCG	0.522000													39	81					0	0	1	0	0
TFRC	7037	broad.mit.edu	37	3	195782158	195782158	+	Silent	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195782158A>C	ENST00000360110.4	-	17	1861	c.1692T>G	c.(1690-1692)ccT>ccG	p.P564P	TFRC_ENST00000392396.3_Silent_p.P564P|TFRC_ENST00000540528.1_3'UTR|TFRC_ENST00000535031.1_Silent_p.P282P|TFRC_ENST00000420415.1_Silent_p.P483P	NM_001128148.1	NP_001121620.1	P02786	TFR1_HUMAN	transferrin receptor	564					cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		TACCCAAATAAGGATAATCTG	0.502000			T	BCL6	NHL								7	42					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121475005	121475005	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:121475005G>A	ENST00000260197.7	+	33	4752	c.4623G>A	c.(4621-4623)tcG>tcA	p.S1541S	SORL1_ENST00000525532.1_Silent_p.S485S|SORL1_ENST00000527934.1_Silent_p.S156S|SORL1_ENST00000532694.1_Silent_p.S387S|SORL1_ENST00000534286.1_Silent_p.S451S	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1541	LDL-receptor class A 11.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGGACTGCTCGGACGAGAGCG	0.667000													10	23					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62768217	62768217	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62768217G>T	ENST00000336232.2	-	3	547	c.412C>A	c.(412-414)Ctc>Atc	p.L138I	SLC22A8_ENST00000545207.1_Missense_Mutation_p.L47I|SLC22A8_ENST00000430500.2_Missense_Mutation_p.L138I|SLC22A8_ENST00000542795.1_5'UTR|SLC22A8_ENST00000311438.8_Missense_Mutation_p.L138I|SLC22A8_ENST00000535878.1_Missense_Mutation_p.L15I	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	138					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						CCAAGCACGAGCCCTCCAATC	0.557000													38	49					1.7489e-18	1.93039e-18	1	1	0
TNFSF8	944	broad.mit.edu	37	9	117692505	117692505	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:117692505C>T	ENST00000223795.2	-	1	192	c.79G>A	c.(79-81)Gtg>Atg	p.V27M		NM_001244.3	NP_001235.1	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily, member 8	27					cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(3)|urinary_tract(1)	12						TGGCTGGCCACGGAGCCCGCC	0.577000													28	27					0	0	1	0	0
ST14	6768	broad.mit.edu	37	11	130060404	130060404	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:130060404G>A	ENST00000278742.5	+	7	1108	c.690G>A	c.(688-690)acG>acA	p.T230T		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	230	CUB 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GCTTCACCACGCCCGGCTTCC	0.692000													10	22					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25051910	25051910	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:25051910T>A	ENST00000381989.3	-	14	1823	c.1718A>T	c.(1717-1719)gAc>gTc	p.D573V		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	573	PARP catalytic.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		AGGATGAAAGTCCTTTATCTG	0.313000													47	60					0	0	1	0	0
HPS4	89781	broad.mit.edu	37	22	26860178	26860178	+	Missense_Mutation	SNP	C	C	T	rs139039617		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:26860178C>T	ENST00000398145.2	-	11	2034	c.1418G>A	c.(1417-1419)cGc>cAc	p.R473H	HPS4_ENST00000402105.3_Missense_Mutation_p.R468H|HPS4_ENST00000336873.5_Missense_Mutation_p.R473H|HPS4_ENST00000398141.1_Missense_Mutation_p.R486H	NM_022081.4	NP_071364.4	Q9NQG7	HPS4_HUMAN	Hermansky-Pudlak syndrome 4	473					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						TGGATCTAAGCGAGGCAATAA	0.592000									Hermansky-Pudlak syndrome				47	79					0	0	1	0	0
GSTM2	2946	broad.mit.edu	37	1	110212156	110212156	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110212156G>A	ENST00000369831.2	+	5	417	c.323G>A	c.(322-324)cGt>cAt	p.R108H	GSTM2_ENST00000241337.4_Missense_Mutation_p.R108H|GSTM2_ENST00000464206.1_Intron|GSTM2_ENST00000442650.1_Missense_Mutation_p.R108H|GSTM2_ENST00000414179.2_Missense_Mutation_p.R4H|GSTM2_ENST00000460717.3_Missense_Mutation_p.R108H|GSTM2_ENST00000369829.2_Missense_Mutation_p.R108H|GSTM2_ENST00000369827.3_Missense_Mutation_p.R106H					glutathione S-transferase mu 2 (muscle)											kidney(1)|large_intestine(2)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	11		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)		ATGGACAGCCGTATGCAGCTG	0.537000													6	17					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111564770	111564770	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:111564770G>A	ENST00000393923.3	+	2	310	c.55G>A	c.(55-57)Gtg>Atg	p.V19M	PLCXD2_ENST00000477665.1_3'UTR|PLCXD2_ENST00000393934.3_3'UTR	NM_001134437.1	NP_001127909.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	0						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						AGTTGGTGATGTGCAACATTT	0.428000													7	64					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45455823	45455823	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:45455823G>A	ENST00000321429.4	+	33	4749	c.4342G>A	c.(4342-4344)Gtg>Atg	p.V1448M	DUOX1_ENST00000389037.3_Missense_Mutation_p.V1448M|CTD-2651B20.1_ENST00000558039.1_lincRNA|DUOX1_ENST00000561166.1_Missense_Mutation_p.V1094M	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	1448					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CCAGGACCTGGTGTCTGTGCA	0.582000											OREG0023103	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	37					0	0	1	0	0
CXCR2	3579	broad.mit.edu	37	2	218999889	218999889	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:218999889T>G	ENST00000318507.2	+	3	792	c.365T>G	c.(364-366)gTc>gGc	p.V122G		NM_001557.3	NP_001548.1	P25025	CXCR2_HUMAN	chemokine (C-X-C motif) receptor 2	122					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(11)|skin(1)|stomach(1)	22						TGCAAGGTGGTCTCACTCCTG	0.552000													18	30					0	0	1	0	0
WDR31	114987	broad.mit.edu	37	9	116082637	116082637	+	Splice_Site	SNP	C	C	T	rs148709910		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:116082637C>T	ENST00000374193.4	-	9	1026	c.780_splice	c.e9+1	p.T260_splice	WDR31_ENST00000374195.3_Splice_Site_p.T135_splice|WDR31_ENST00000461942.1_5'UTR|WDR31_ENST00000341761.4_Splice_Site_p.T259_splice	NM_001012361.2|NM_145241.3	NP_001012361.1|NP_660284.1	Q8NA23	WDR31_HUMAN	WD repeat domain 31	260								p.T260T(1)		NS(1)|large_intestine(1)|lung(2)|prostate(2)	6						AGTCTCCTACCGTGGCTTCAC	0.517000													18	31					0	0	1	0	0
APOO	79135	broad.mit.edu	37	X	23876770	23876770	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:23876770C>T	ENST00000379226.4	-	6	700	c.469G>A	c.(469-471)Gtg>Atg	p.V157M	APOO_ENST00000379220.3_Missense_Mutation_p.V138M	NM_024122.4	NP_077027.1	Q9BUR5	APOO_HUMAN	apolipoprotein O	157					lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(5)|prostate(1)	9						TGGGCAAACACGATGGCTTGT	0.378000													23	2					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48583507	48583507	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:48583507G>A	ENST00000537810.1	-	21	2706	c.2102C>T	c.(2101-2103)gCc>gTc	p.A701V	FRYL_ENST00000506685.1_Missense_Mutation_p.A407V|FRYL_ENST00000507711.1_Missense_Mutation_p.A701V|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000503238.1_Missense_Mutation_p.A701V|FRYL_ENST00000358350.4_Missense_Mutation_p.A701V			O94915	FRYL_HUMAN	FRY-like	701					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						TCTCCTAGTGGCAGGTCGACT	0.453000													25	37					0	0	1	0	0
EPN2	22905	broad.mit.edu	37	17	19186472	19186472	+	Missense_Mutation	SNP	G	G	A	rs138967323		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:19186472G>A	ENST00000314728.5	+	3	524	c.40G>A	c.(40-42)Gtg>Atg	p.V14M	EPN2_ENST00000395620.2_Missense_Mutation_p.V14M|EPN2_ENST00000571254.1_Missense_Mutation_p.V14M|EPN2_ENST00000395626.1_Missense_Mutation_p.V14M|EPN2_ENST00000395618.3_Intron|EPN2_ENST00000347697.2_Missense_Mutation_p.V14M|EPN2_ENST00000575595.1_Intron	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	14	ENTH.				endocytosis		lipid binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					GAAAAACATCGTGAACAATTA	0.463000													16	19					0	0	1	0	0
GPBAR1	151306	broad.mit.edu	37	2	219127556	219127556	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219127556C>T	ENST00000522678.1	+	2	977	c.109C>T	c.(109-111)Ctg>Ttg	p.L37L	GPBAR1_ENST00000479077.1_Silent_p.L37L|GPBAR1_ENST00000519574.1_Silent_p.L37L|GPBAR1_ENST00000521462.1_Silent_p.L37L	NM_001077191.1	NP_001070659.1	Q8TDU6	GPBAR_HUMAN	G protein-coupled bile acid receptor 1	37						integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|kidney(1)|large_intestine(1)|ovary(1)	4		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTCCTAGCCCTGGGCATCGC	0.677000													7	14					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29819560	29819560	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:29819560G>A	ENST00000375398.2	-	13	2531	c.2082C>T	c.(2080-2082)gtC>gtT	p.V694V	SVIL_ENST00000375400.3_Silent_p.V300V|SVIL_ENST00000355867.4_Silent_p.V694V			O95425	SVIL_HUMAN	supervillin	694					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TCTTGGCGGCGACGCTCAGCT	0.473000													8	86					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41566427	41566427	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:41566427G>A	ENST00000396942.1	-	17	1950	c.1867C>T	c.(1867-1869)Cag>Tag	p.Q623*	ANK1_ENST00000347528.4_Nonsense_Mutation_p.Q623*|ANK1_ENST00000289734.7_Nonsense_Mutation_p.Q623*|ANK1_ENST00000265709.8_Nonsense_Mutation_p.Q656*|ANK1_ENST00000396945.1_Nonsense_Mutation_p.Q623*|ANK1_ENST00000352337.4_Nonsense_Mutation_p.Q623*|ANK1_ENST00000379758.2_Nonsense_Mutation_p.Q623*			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	623	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCCCCATACTGCAGCAGACTA	0.622000													4	74					0	0	1	0	0
GMPPB	29925	broad.mit.edu	37	3	49759462	49759462	+	Missense_Mutation	SNP	C	C	T	rs144040971	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49759462C>T	ENST00000480687.1	-	9	1003	c.887G>A	c.(886-888)cGg>cAg	p.R296Q	AMIGO3_ENST00000535833.1_5'UTR|GMPPB_ENST00000308388.6_Missense_Mutation_p.R296Q|GMPPB_ENST00000308375.6_Missense_Mutation_p.R296Q			Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B	296					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGAACGGATCCGGGCATCCCG	0.662000													8	15					0	0	1	0	0
NBN	4683	broad.mit.edu	37	8	90970998	90970998	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:90970998G>A	ENST00000265433.3	-	9	1233	c.1079C>T	c.(1078-1080)aCt>aTt	p.T360I	NBN_ENST00000409330.1_Missense_Mutation_p.T278I	NM_002485.4	NP_002476.2	O60934	NBN_HUMAN	nibrin	360					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(11;0.0344)			GTATGTTGTAGTGTTCACTGG	0.388000								Homologous recombination					57	84					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47270020	47270020	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:47270020G>A	ENST00000396220.1	-	20	2247	c.2225C>T	c.(2224-2226)gCt>gTt	p.A742V	PREX1_ENST00000371941.3_Missense_Mutation_p.A742V			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	742					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GAGCCCTGCAGCCATGGCCTC	0.602000													33	51					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81744924	81744924	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:81744924A>G	ENST00000555447.1	-	6	1143	c.731T>C	c.(730-732)tTa>tCa	p.L244S	STON2_ENST00000267540.2_Missense_Mutation_p.L244S|STON2_ENST00000556280.1_5'UTR	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	244					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GACTGGTGGTAAAGGGCAGCT	0.512000													18	36					0	0	1	0	0
AC097374.2	0	broad.mit.edu	37	2	95552771	95552771	+	RNA	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:95552771T>C	ENST00000568768.1	-	0	476																											AATTCCTCCTTTGTCATAAAG	0.383000													7	10					0	0	1	0	0
CELF1	10658	broad.mit.edu	37	11	47505049	47505049	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:47505049C>T	ENST00000395290.2	-	5	487	c.478G>A	c.(478-480)Gca>Aca	p.A160T	CELF1_ENST00000361904.3_Missense_Mutation_p.A161T|CELF1_ENST00000310513.5_Missense_Mutation_p.A161T|CELF1_ENST00000532048.1_Missense_Mutation_p.A187T|CELF1_ENST00000531165.1_Missense_Mutation_p.A188T|CELF1_ENST00000358597.3_Missense_Mutation_p.A161T|CELF1_ENST00000395292.2_Missense_Mutation_p.A161T	NM_001025596.2|NM_001172640.1	NP_001020767.1|NP_001166111.1	Q92879	CELF1_HUMAN	CUGBP, Elav-like family member 1	161	RRM 2.				embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)	18						GCCGTCTGTGCCATGGCTCTT	0.458000													5	125					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133319805	133319805	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:133319805C>T	ENST00000539605.1	-	5	7786	c.1102G>A	c.(1102-1104)Gtg>Atg	p.V368M	ANKLE2_ENST00000337516.5_Missense_Mutation_p.V430M|ANKLE2_ENST00000357997.5_Missense_Mutation_p.V430M			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	430						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		GACGAAAGCACGTTGACTACA	0.363000													12	17					0	0	1	0	0
ZNF180	7733	broad.mit.edu	37	19	44980970	44980970	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44980970C>T	ENST00000221327.4	-	5	2009	c.1728G>A	c.(1726-1728)ccG>ccA	p.P576P	ZNF180_ENST00000391956.4_Silent_p.P551P|ZNF180_ENST00000592529.1_Silent_p.P549P	NM_013256.3	NP_037388.2	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	576					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				TACATTCATACGGTTTTTCCC	0.403000													40	55					0	0	1	0	0
KCTD11	147040	broad.mit.edu	37	17	7256426	7256426	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7256426G>A	ENST00000333751.3	+	1	1219	c.165G>A	c.(163-165)gcG>gcA	p.A55A	RP11-542C16.1_ENST00000572417.1_RNA	NM_001002914.2	NP_001002914.1	Q693B1	KCD11_HUMAN	potassium channel tetramerization domain containing 11	55					cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity			kidney(1)|large_intestine(2)|lung(1)	4		Prostate(122;0.157)				GAGAGACAGCGCTGCTCAGGG	0.667000													6	7					0	0	1	0	0
IFI35	3430	broad.mit.edu	37	17	41166147	41166147	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41166147G>A	ENST00000415816.2	+	7	915	c.692G>A	c.(691-693)cGc>cAc	p.R231H	IFI35_ENST00000438323.2_Missense_Mutation_p.R233H	NM_005533.4	NP_005524.2	P80217	IN35_HUMAN	interferon-induced protein 35	231					response to virus|type I interferon-mediated signaling pathway	nucleus	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)	8		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.157)		CCAGTTCCCCGCTCGGTACTG	0.632000													30	58					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46245688	46245688	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:46245688G>A	ENST00000334344.6	+	15	3954	c.3782G>A	c.(3781-3783)cGt>cAt	p.R1261H	ARID2_ENST00000422737.1_Missense_Mutation_p.R1112H|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000444670.1_Missense_Mutation_p.R871H	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1261					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GTTCATGAACGTAAAATTGAA	0.428000			"""N, S, F"""		hepatocellular carcinoma								11	27					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64617536	64617536	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:64617536G>A	ENST00000498707.1	-	15	2583	c.2241C>T	c.(2239-2241)ggC>ggT	p.G747G	ADAMTS9_ENST00000295903.4_Silent_p.G719G	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	747	Cys-rich.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		AAGAATTATCGCCACCACAAA	0.363000													31	46					0	0	1	0	0
NUCB1	4924	broad.mit.edu	37	19	49409102	49409102	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49409102G>A	ENST00000405315.4	+	4	670	c.336G>A	c.(334-336)cgG>cgA	p.R112R	NUCB1_ENST00000407032.1_Silent_p.R112R|NUCB1_ENST00000485798.1_Intron|NUCB1_ENST00000263273.5_Silent_p.R112R	NM_006184.5	NP_006175.2	Q02818	NUCB1_HUMAN	nucleobindin 1	112						ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding			cervix(1)|endometrium(4)|large_intestine(4)|lung(8)	17		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		CACGGCTGCGGATGCTGCTCA	0.657000													12	18					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62253392	62253392	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:62253392C>T	ENST00000474889.1	+	19	3149	c.2772C>T	c.(2770-2772)acC>acT	p.T924T	PTPRG-AS1_ENST00000462497.1_RNA|PTPRG_ENST00000295874.10_Silent_p.T895T|PTPRG-AS1_ENST00000474795.1_RNA|PTPRG-AS1_ENST00000479018.1_RNA|PTPRG-AS1_ENST00000475371.1_RNA|PTPRG-AS1_ENST00000495542.1_RNA	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	924	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ACATTGCCACCCAAGGACCTT	0.383000													50	65					0	0	1	0	0
PIH1D1	55011	broad.mit.edu	37	19	49954061	49954061	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49954061C>T	ENST00000262265.5	-	2	370	c.135G>A	c.(133-135)tcG>tcA	p.S45S	PIH1D1_ENST00000596049.1_Silent_p.S45S	NM_017916.2	NP_060386.1	Q9NWS0	PIHD1_HUMAN	PIH1 domain containing 1	45					box C/D snoRNP assembly	pre-snoRNP complex				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|urinary_tract(1)	11		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		GGATTTGTGTCGATTCTGGTC	0.552000													35	73					0	0	1	0	0
FZD9	8326	broad.mit.edu	37	7	72849639	72849639	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:72849639C>T	ENST00000344575.3	+	1	1531	c.1302C>T	c.(1300-1302)ggC>ggT	p.G434G		NM_003508.2	NP_003499.1	O00144	FZD9_HUMAN	frizzled family receptor 9	434					B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	14		Lung NSC(55;0.0659)|all_lung(88;0.152)				TGAAGACGGGCGGCACCAACA	0.587000													3	19					0	0	1	0	0
PLK1	5347	broad.mit.edu	37	16	23700886	23700886	+	Silent	SNP	G	G	A	rs139428942	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:23700886G>A	ENST00000300093.4	+	9	1608	c.1497G>A	c.(1495-1497)ccG>ccA	p.P499P		NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	499	Linker.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		ACATCACGCCGCGCGAAGGTG	0.577000													17	25					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21687107	21687107	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:21687107C>T	ENST00000398485.2	+	2	372	c.318C>T	c.(316-318)ggC>ggT	p.G106G	PAX1_ENST00000444366.2_Silent_p.G82G|PAX1_ENST00000460221.1_Intron	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	106	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						ACCAGCTGGGCGGTGTGTTCG	0.662000													20	32					0	0	1	0	0
RBPJ	3516	broad.mit.edu	37	4	26407825	26407825	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:26407825C>T	ENST00000342320.4	+	3	261	c.85C>T	c.(85-87)Cga>Tga	p.R29*	RBPJ_ENST00000348160.4_Nonsense_Mutation_p.R30*|RBPJ_ENST00000355476.3_Nonsense_Mutation_p.R29*|RBPJ_ENST00000342295.1_Nonsense_Mutation_p.R43*|RBPJ_ENST00000504907.1_Nonsense_Mutation_p.R29*|RBPJ_ENST00000507561.1_Nonsense_Mutation_p.R8*|RBPJ_ENST00000361572.6_Nonsense_Mutation_p.R43*|RBPJ_ENST00000511401.1_3'UTR|RBPJ_ENST00000345843.3_Nonsense_Mutation_p.R28*			Q06330	SUH_HUMAN	recombination signal binding protein for immunoglobulin kappa J region	43					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)	15		Breast(46;0.0503)				TTTAAAAGAGCGAGGGGATCA	0.318000													22	44					0	0	1	0	0
CDC42EP2	10435	broad.mit.edu	37	11	65088567	65088567	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65088567G>A	ENST00000544348.1	+	2	804	c.198G>A	c.(196-198)ccG>ccA	p.P66P	CDC42EP2_ENST00000279249.2_Silent_p.P66P|CDC42EP2_ENST00000533419.1_Silent_p.P66P			O14613	BORG1_HUMAN	CDC42 effector protein (Rho GTPase binding) 2	66					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity			lung(1)	1						ACCTCCTGCCGGGGACCATGG	0.652000													20	41					0	0	1	0	0
PCDHB15	0	broad.mit.edu	37	5	140626753	140626753	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140626753G>A	ENST00000231173.3	+	1	1607	c.1607G>A	c.(1606-1608)cGc>cAc	p.R536H		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		536	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCACAGACCGCGGCTTCCCG	0.662000													19	28					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47049635	47049635	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47049635G>A	ENST00000450053.3	+	50	7857	c.7678G>A	c.(7678-7680)Gcc>Acc	p.A2560T	NBEAL2_ENST00000292309.5_Missense_Mutation_p.A2376T|NBEAL2_ENST00000383740.2_Missense_Mutation_p.A809T	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2560							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GAGCTGTGTGGCCATCAGCAC	0.597000													13	16					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94748478	94748478	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:94748478C>A	ENST00000399300.2	-	3	374	c.161G>T	c.(160-162)aGa>aTa	p.R54I	RBM12B_ENST00000520961.1_Intron|RBM12B_ENST00000517700.1_Missense_Mutation_p.R54I	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	54							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TATGGCACGTCTTGCATCTTC	0.408000													40	66					1.47244e-24	1.64277e-24	1	1	0
TCTN2	79867	broad.mit.edu	37	12	124191586	124191586	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:124191586G>A	ENST00000303372.5	+	17	2078	c.1950G>A	c.(1948-1950)ccG>ccA	p.P650P	TCTN2_ENST00000426174.2_Silent_p.P649P	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	650					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TGTGTTGGCCGCAGCTTCTAT	0.328000													21	25					0	0	1	0	0
SERPING1	710	broad.mit.edu	37	11	57367677	57367677	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57367677C>A	ENST00000403558.1	+	2	845	c.479C>A	c.(478-480)cCt>cAt	p.P160H	SERPING1_ENST00000278407.4_Missense_Mutation_p.P126H|SERPING1_ENST00000378324.2_Missense_Mutation_p.P74H|SERPING1_ENST00000378323.4_Missense_Mutation_p.P131H|SERPING1_ENST00000340687.6_Missense_Mutation_p.P126H	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	126					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						TGCCCAGGACCTGTTACTCTC	0.562000													58	97					6.1719e-39	6.93416e-39	1	1	0
FAM57A	79850	broad.mit.edu	37	17	641189	641189	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:641189C>T	ENST00000308278.8	+	3	546	c.310C>T	c.(310-312)Cgt>Tgt	p.R104C	FAM57A_ENST00000572018.1_Intron|FAM57A_ENST00000301324.8_Missense_Mutation_p.R104C	NM_024792.1	NP_079068.1	Q8TBR7	FA57A_HUMAN	family with sequence similarity 57, member A	104	TLC.					integral to membrane|plasma membrane		p.R104C(1)		cervix(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)|urinary_tract(2)	10				UCEC - Uterine corpus endometrioid carcinoma (25;0.0217)		AGACCAGAACCGTGCGCCCTC	0.517000													11	153					0	0	1	0	0
SLC7A5	8140	broad.mit.edu	37	16	87874675	87874675	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:87874675G>T	ENST00000261622.4	-	3	816	c.751C>A	c.(751-753)Ctc>Atc	p.L251I	SLC7A5_ENST00000565644.1_5'UTR	NM_003486.5	NP_003477.4	Q01650	LAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 5	251					blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(80;0.049)		TAGGCAAAGAGGCCGCTGTAT	0.522000													13	46					4.93089e-13	5.3475e-13	1	1	0
PRMT7	54496	broad.mit.edu	37	16	68358611	68358611	+	Missense_Mutation	SNP	G	G	A	rs143219221		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:68358611G>A	ENST00000339507.5	+	5	988	c.158G>A	c.(157-159)cGg>cAg	p.R53Q	PRMT7_ENST00000449359.3_Intron|PRMT7_ENST00000348497.4_Missense_Mutation_p.R53Q|PRMT7_ENST00000564441.1_3'UTR|PRMT7_ENST00000441236.1_Intron			Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	53					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|urinary_tract(1)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CAAGGTATCCGGGCTGCCGTG	0.488000													3	36					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121786403	121786403	+	Missense_Mutation	SNP	C	C	T	rs28937592	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:121786403C>T	ENST00000261367.7	+	12	3430	c.2002C>T	c.(2002-2004)Cgc>Tgc	p.R668C	SNCAIP_ENST00000504884.2_3'UTR|CTC-210G5.1_ENST00000509993.1_RNA|SNCAIP_ENST00000379538.3_Missense_Mutation_p.R255C|SNCAIP_ENST00000261368.8_Missense_Mutation_p.R621C|CTC-210G5.1_ENST00000505546.1_RNA|SNCAIP_ENST00000414317.2_Missense_Mutation_p.R223C|CTC-210G5.1_ENST00000503529.1_RNA|SNCAIP_ENST00000542191.1_Missense_Mutation_p.R179C|CTC-210G5.1_ENST00000506053.1_RNA|SNCAIP_ENST00000503116.2_3'UTR|SNCAIP_ENST00000379533.2_Missense_Mutation_p.R668C|SNCAIP_ENST00000379536.2_Missense_Mutation_p.R561C|CTC-210G5.1_ENST00000510972.1_RNA			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	621					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding	p.R668C(2)|p.R621C(2)		NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TAAAATCTTACGCCAGTTATT	0.458000													16	28					0	0	1	0	0
COMMD4	54939	broad.mit.edu	37	15	75632054	75632054	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75632054G>A	ENST00000267935.8	+	7	593	c.394G>A	c.(394-396)Gca>Aca	p.A132T	COMMD4_ENST00000338995.6_Intron|COMMD4_ENST00000567195.1_Intron|COMMD4_ENST00000562789.1_Intron|COMMD4_ENST00000564815.1_Missense_Mutation_p.A110T	NM_017828.3	NP_060298.2	Q9H0A8	COMD4_HUMAN	COMM domain containing 4	132	COMM.					cytoplasm	protein binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|prostate(1)	10						GAATAGGTTGGCAGGTGTGGG	0.617000													9	13					0	0	1	0	0
CCDC74B	91409	broad.mit.edu	37	2	130900698	130900698	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:130900698C>T	ENST00000409234.3	-	2	525	c.439G>A	c.(439-441)Gct>Act	p.A147T	CCDC74B_ENST00000409128.1_Intron|CCDC74B_ENST00000310463.6_Intron|CCDC74B_ENST00000409943.3_Intron|CCDC74B_ENST00000392984.3_5'UTR			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	285										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					CTAGAGGTAGCGGCATCTGTC	0.647000													4	3					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86304988	86304988	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:86304988A>G	ENST00000263857.6	-	11	1752	c.1374T>C	c.(1372-1374)atT>atC	p.I458I	POLR1A_ENST00000409681.1_Silent_p.I458I			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	458					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						acacCATGGGAATTCCAATTT	0.552000													10	64					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69409770	69409770	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:69409770G>A	ENST00000303714.4	+	16	1653	c.1331G>A	c.(1330-1332)cGg>cAg	p.R444Q		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	444					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						TCTTCCCCCCGGAAGTGGTAC	0.428000									Familial Infantile Hemangioma				22	37					0	0	1	0	0
LLGL1	3996	broad.mit.edu	37	17	18144821	18144821	+	Missense_Mutation	SNP	G	G	T	rs56406965		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18144821G>T	ENST00000316843.4	+	18	2655	c.2559G>T	c.(2557-2559)gaG>gaT	p.E853D		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	853					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					CGGCCCATGAGGGCTGTCGTG	0.627000													6	11					0.248553	0.248844	1	1	0
RASGRP3	25780	broad.mit.edu	37	2	33745674	33745674	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:33745674T>C	ENST00000403687.3	+	6	1031	c.291T>C	c.(289-291)cgT>cgC	p.R97R	RASGRP3_ENST00000407811.1_Silent_p.R97R|RASGRP3_ENST00000402538.3_Silent_p.R97R	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	97	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					GTTTGATTCGTATGACTGAGG	0.423000													26	128					0	0	1	0	0
KRT81	3887	broad.mit.edu	37	12	52681897	52681897	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:52681897G>T	ENST00000327741.5	-	5	839	c.771C>A	c.(769-771)acC>acA	p.T257T	KRT86_ENST00000423955.2_Intron|KRT86_ENST00000544024.1_Intron	NM_002281.3	NP_002272.2	Q14533	KRT81_HUMAN	keratin 81	257	Linker 12.|Rod.					keratin filament	protein binding|structural molecule activity			breast(2)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|stomach(1)	16				BRCA - Breast invasive adenocarcinoma(357;0.189)		CAACCACGGAGGTGTCTGAGA	0.552000													4	73					0.150653	0.151081	1	1	0
AMACR	23600	broad.mit.edu	37	5	34005919	34005919	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:34005919G>A	ENST00000335606.6	-	2	421	c.333C>T	c.(331-333)ggC>ggT	p.G111G	AMACR_ENST00000441713.2_Silent_p.G111G|AMACR_ENST00000514195.1_5'UTR|AMACR_ENST00000502637.1_Silent_p.G111G|AMACR_ENST00000382085.3_Silent_p.G111G|AMACR_ENST00000382072.2_Silent_p.G111G	NM_001167595.1|NM_014324.5	NP_001161067.1|NP_055139.4	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase	111					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	19						TTCCTGACTGGCCAAATCCAC	0.433000													5	58					0	0	1	0	0
NPTXR	23467	broad.mit.edu	37	22	39222688	39222688	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:39222688C>T	ENST00000333039.2	-	3	1038	c.915G>A	c.(913-915)atG>atA	p.M305I		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	305	Pentaxin.					integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					CGCGGGCGTACATGTAGTTGT	0.632000													10	26					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599505	29599505	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:29599505G>A	ENST00000431530.3	+	1	758	c.700G>A	c.(700-702)Gct>Act	p.A234T		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	224						cytoplasm|microtubule	microtubule binding|protein homodimerization activity	p.A234S(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GCCAGACCACGCTGTCCCGGC	0.592000													16	11					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1213643	1213643	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1213643G>A	ENST00000304460.10	+	5	785	c.729G>A	c.(727-729)acG>acA	p.T243T		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	243					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GAGGCCTGACGCTGAAGGGCG	0.662000													11	15					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43282055	43282055	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:43282055G>A	ENST00000269844.3	-	6	791	c.681C>T	c.(679-681)caC>caT	p.H227H	PRDM15_ENST00000538201.1_Intron|PRDM15_ENST00000398548.1_Intron|PRDM15_ENST00000422911.1_Intron	NM_022115.3	NP_071398.3	P57071	PRD15_HUMAN	PR domain containing 15	227					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						AAGGTATCTCGTGCGGCTCTA	0.512000													14	7					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33246678	33246678	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33246678G>A	ENST00000373477.4	-	10	2019	c.1111C>T	c.(1111-1113)Cgt>Tgt	p.R371C	YARS_ENST00000469100.1_5'UTR	NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	371	tRNA-binding.				apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	TTCCCCACACGGATATCCAGC	0.507000													32	52					0	0	1	0	0
DLST	1743	broad.mit.edu	37	14	75368922	75368922	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:75368922C>T	ENST00000334220.4	+	15	1312	c.1251C>T	c.(1249-1251)taC>taT	p.Y417Y	DLST_ENST00000334212.6_Silent_p.Y331Y	NM_001933.4	NP_001924.2	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	417					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(234;0.00698)		CCATGATGTACGTGGCACTGA	0.547000													7	10					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306602	2306602	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2306602C>A	ENST00000290974.2	-	8	1804	c.1465G>T	c.(1465-1467)Gac>Tac	p.D489Y	ZFYVE28_ENST00000511071.1_Missense_Mutation_p.D459Y|RP11-478C1.7_ENST00000510632.1_RNA|ZFYVE28_ENST00000515312.1_Missense_Mutation_p.D419Y	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	489					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						TCCCAGCCGTCCAGGTGCAGC	0.652000													30	30					2.85442e-18	3.14927e-18	1	1	0
VANGL2	57216	broad.mit.edu	37	1	160389121	160389121	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160389121G>A	ENST00000368061.2	+	4	996	c.522G>A	c.(520-522)tcG>tcA	p.S174S		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	174					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCAAGGCCTCGCTGCCCCGCG	0.627000													30	34					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64168355	64168355	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:64168355G>A	ENST00000395391.1	+	4	3048	c.1673G>A	c.(1672-1674)gGc>gAc	p.G558D	ZNF107_ENST00000344930.3_Missense_Mutation_p.G558D|ZNF107_ENST00000423627.1_Missense_Mutation_p.G558D			Q9UII5	ZN107_HUMAN	zinc finger protein 107	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				GAAGAACATGGCAAAGTTTTT	0.348000													36	52					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57077271	57077271	+	Missense_Mutation	SNP	C	C	T	rs148640580	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57077271C>T	ENST00000532437.1	-	5	3225	c.2914G>A	c.(2914-2916)Gcc>Acc	p.A972T	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.A972T			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	972	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CTGTCCTGGGCGTCAAGGGTC	0.577000													17	76					0	0	1	0	0
RNF103	7844	broad.mit.edu	37	2	86839316	86839316	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:86839316G>A	ENST00000237455.4	-	3	1416	c.448C>T	c.(448-450)Cgt>Tgt	p.R150C	AC015971.2_ENST00000439077.1_RNA|AC015971.2_ENST00000426549.1_RNA|AC015971.2_ENST00000424788.1_RNA|RNF103-CHMP3_ENST00000604011.1_Intron|AC015971.2_ENST00000597638.1_RNA|RNF103_ENST00000477307.1_5'UTR|CHMP3_ENST00000439940.2_Intron	NM_001198951.1|NM_005667.3	NP_001185880.1|NP_005658.1	O00237	RN103_HUMAN	ring finger protein 103	150					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(7)|skin(2)	25						GTGCCTGTACGTATTCCAAAT	0.388000													30	39					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234556542	234556542	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:234556542T>G	ENST00000040877.1	-	21	3460	c.3461A>C	c.(3460-3462)aAg>aCg	p.K1154T		NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1154					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			TTTTTTGGACTTGGACACTAA	0.383000													19	38					0	0	1	0	0
ALG9	79796	broad.mit.edu	37	11	111747585	111747585	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:111747585G>A	ENST00000524880.1	-	3	772	c.480C>T	c.(478-480)gaC>gaT	p.D160D	FDXACB1_ENST00000542429.1_Silent_p.D11D|FDXACB1_ENST00000260257.4_Silent_p.D160D			Q9H6U8	ALG9_HUMAN	ALG9, alpha-1,2-mannosyltransferase	0					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		ATGGATACACGTCGCTTAAAA	0.512000													8	8					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179407817	179407817	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179407817C>T	ENST00000589042.1	-	347	97107	c.96883G>A	c.(96883-96885)Gtg>Atg	p.V32295M	TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V23422M|TTN_ENST00000591111.1_Missense_Mutation_p.V30654M|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V23230M|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V29727M|TTN_ENST00000359218.5_Missense_Mutation_p.V23355M|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30654	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTACAGTCACGGCTGTGACA	0.343000													63	80					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61467852	61467852	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:61467852G>A	ENST00000343916.3	+	29	1574	c.1571G>A	c.(1570-1572)cGc>cAc	p.R524H	COL9A3_ENST00000462700.1_Intron	NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	524	Nonhelical region 3 (NC3).			R -> H (in Ref. 5; CAA62495).	axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					AGCGAGCAGCGCATCAGGGAG	0.672000													8	9					0	0	1	0	0
ZMYND12	84217	broad.mit.edu	37	1	42915624	42915624	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:42915624G>A	ENST00000372565.3	-	2	486	c.217C>T	c.(217-219)Cgg>Tgg	p.R73W	ZMYND12_ENST00000433602.2_Missense_Mutation_p.T20M	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	73						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCATGCTGCCGTTCTTCCTCT	0.547000													25	35					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45867699	45867699	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:45867699C>A	ENST00000311275.7	-	15	2661	c.2408G>T	c.(2407-2409)aGg>aTg	p.R803M	ZMYND8_ENST00000352431.2_Missense_Mutation_p.R823M|ZMYND8_ENST00000540497.1_Missense_Mutation_p.R751M|ZMYND8_ENST00000458360.2_Intron|ZMYND8_ENST00000396281.4_Missense_Mutation_p.R803M|ZMYND8_ENST00000262975.4_Missense_Mutation_p.R803M|ZMYND8_ENST00000536340.1_Missense_Mutation_p.R830M|ZMYND8_ENST00000471951.2_Missense_Mutation_p.R823M|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000355972.4_Missense_Mutation_p.R803M|ZMYND8_ENST00000372023.3_Missense_Mutation_p.R798M|ZMYND8_ENST00000360911.3_Missense_Mutation_p.R798M|ZMYND8_ENST00000461685.1_Missense_Mutation_p.R823M|ZMYND8_ENST00000446994.2_Missense_Mutation_p.R740M			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	803							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TAAAAGCGGCCTCTGCTTTTT	0.632000													12	64					9.31168e-06	9.64599e-06	1	1	0
USP7	7874	broad.mit.edu	37	16	8988926	8988926	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:8988926C>T	ENST00000344836.4	-	28	3199	c.3001G>A	c.(3001-3003)Gga>Aga	p.G1001R	USP7_ENST00000381886.4_Missense_Mutation_p.G985R|USP7_ENST00000535863.1_Missense_Mutation_p.G902R	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	1001					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						CCGAACGTTCCGAAGACCTCT	0.527000													78	119					0	0	1	0	0
KLF12	11278	broad.mit.edu	37	13	74269699	74269699	+	Silent	SNP	G	G	A	rs149878794	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:74269699G>A	ENST00000377669.2	-	7	1163	c.1137C>T	c.(1135-1137)tgC>tgT	p.C379C	KLF12_ENST00000377666.4_Silent_p.C379C	NM_007249.4	NP_009180.3	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	379					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		CACAGTCCGCGCACTTGAATG	0.542000													36	12					0	0	1	0	0
SLC22A12	116085	broad.mit.edu	37	11	64359171	64359171	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64359171G>A	ENST00000473690.1	+	0	361				SLC22A12_ENST00000336464.7_Missense_Mutation_p.R48H|SLC22A12_ENST00000377567.2_Missense_Mutation_p.R48H|SLC22A12_ENST00000377574.1_Missense_Mutation_p.R48H|SLC22A12_ENST00000377572.1_Missense_Mutation_p.R48H	NM_153378.1	NP_700357.1	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12						cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity	p.S41fs*22(1)		central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						CCCAGCCACCGCTGCTGGGCA	0.637000													13	24					0	0	1	0	0
RNASEL	6041	broad.mit.edu	37	1	182555276	182555276	+	Silent	SNP	C	C	T	rs141997272	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:182555276C>T	ENST00000367559.3	-	2	919	c.666G>A	c.(664-666)acG>acA	p.T222T	RNASEL_ENST00000539397.1_Silent_p.T222T|RNASEL_ENST00000444138.1_Silent_p.T222T	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	222					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						GCAGCAGATGCGTAATAGCCT	0.527000													19	30					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504190	70504190	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:70504190G>A	ENST00000310961.5	+	22	3002	c.2584G>A	c.(2584-2586)Gct>Act	p.A862T	LRRC7_ENST00000415775.2_Missense_Mutation_p.A141T|LRRC7_ENST00000035383.5_Missense_Mutation_p.A857T			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	857						centrosome|focal adhesion|nucleolus	protein binding	p.A857T(1)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGACAGGACCGCTTTTCCTTC	0.468000													31	58					0	0	1	0	0
FOXD2	2306	broad.mit.edu	37	1	47904507	47904507	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47904507C>T	ENST00000334793.5	+	1	2819	c.700C>T	c.(700-702)Cac>Tac	p.H234Y		NM_004474.3	NP_004465.3	O60548	FOXD2_HUMAN	forkhead box D2	234	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(4)	4				READ - Rectum adenocarcinoma(2;0.0908)		GCCGCACCCACACCCGCACCC	0.746000													12	12					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46727177	46727177	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46727177G>T	ENST00000311764.2	+	5	2157	c.1927G>T	c.(1927-1929)Gct>Tct	p.A643S		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	643					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TGTGCCTTCTGCTGCTTCTGA	0.642000													9	24					3.86212e-05	3.97146e-05	1	1	0
P2RY2	5029	broad.mit.edu	37	11	72946266	72946266	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:72946266C>T	ENST00000311131.2	+	3	1529	c.1062C>T	c.(1060-1062)ggC>ggT	p.G354G	P2RY2_ENST00000393597.2_Silent_p.G354G|P2RY2_ENST00000393596.2_Silent_p.G354G	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	354					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	ATGTGTTGGGCAGCAGTGAGG	0.617000													20	46					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255001	15255001	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:15255001G>A	ENST00000378116.4	-	8	2592	c.2586C>T	c.(2584-2586)gaC>gaT	p.D862D		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	862						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CATCATCATCGTCTTCCTCTT	0.582000													29	81					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64504445	64504445	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64504445C>T	ENST00000377494.1	-	8	1797	c.875G>A	c.(874-876)cGg>cAg	p.R292Q	RASGRP2_ENST00000394432.3_Missense_Mutation_p.R292Q|RASGRP2_ENST00000354024.3_Missense_Mutation_p.R292Q|RASGRP2_ENST00000377497.3_Missense_Mutation_p.R292Q			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	292	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GGCTGCCAGCCGACGCCGGTA	0.632000													11	14					0	0	1	0	0
FARP1	10160	broad.mit.edu	37	13	99091369	99091369	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:99091369C>T	ENST00000376586.2	+	22	2781	c.2445C>T	c.(2443-2445)gaC>gaT	p.D815D	FARP1_ENST00000319562.6_Silent_p.D784D|FARP1_ENST00000595437.1_Silent_p.D815D			Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	784	PH 1.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGTTCAACGACGTCCTGCTAT	0.572000													37	61					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41737137	41737137	+	Silent	SNP	G	G	A	rs142452494		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41737137G>A	ENST00000301178.4	+	6	907	c.717G>A	c.(715-717)acG>acA	p.T239T	AXL_ENST00000593513.1_5'UTR|AXL_ENST00000359092.3_Silent_p.T239T	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	239	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.T239T(1)		breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						GCCAACCCACGGAGCTGGAGG	0.612000													11	18					0	0	1	0	0
PIWIL2	55124	broad.mit.edu	37	8	22137041	22137041	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22137041G>T	ENST00000356766.6	+	2	290	c.142G>T	c.(142-144)Ggc>Tgc	p.G48C	PIWIL2_ENST00000521356.1_Missense_Mutation_p.G48C|PIWIL2_ENST00000454009.2_Missense_Mutation_p.G48C	NM_018068.3	NP_060538.2	Q8TC59	PIWL2_HUMAN	piwi-like RNA-mediated gene silencing 2	48					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		TGCAGGCAGAGGCCATGTATT	0.577000													5	62					0.000602214	0.000612743	1	1	0
TNXB	7148	broad.mit.edu	37	6	32065948	32065948	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32065948A>T	ENST00000375244.3	-	2	229	c.28T>A	c.(28-30)Tcc>Acc	p.S10T	TNXB_ENST00000479795.1_Missense_Mutation_p.S10T|TNXB_ENST00000375247.2_Missense_Mutation_p.S10T			P22105	TENX_HUMAN	tenascin XB	10					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ACCAGGCTGGAGGTTAGAGCA	0.587000													7	16					0	0	1	0	0
SPESP1	246777	broad.mit.edu	37	15	69223001	69223001	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:69223001C>A	ENST00000310673.3	+	1	163	c.9C>A	c.(7-9)ccC>ccA	p.P3P	RP11-809H16.2_ENST00000557966.1_RNA|SPESP1_ENST00000560188.1_Intron|NOX5_ENST00000448182.3_5'UTR|NOX5_ENST00000260364.5_5'UTR|NOX5_ENST00000455873.3_5'UTR	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	3					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						CTATGAAGCCCTTAGTCCTTC	0.627000													59	99					2.53126e-37	2.84264e-37	1	1	0
OR51B2	79345	broad.mit.edu	37	11	5345138	5345138	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5345138A>G	ENST00000328813.2	-	1	444	c.390T>C	c.(388-390)taT>taC	p.Y130Y	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033180.4	NP_149420.4	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B, member 2	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|large_intestine(6)|lung(21)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAATGGAAGCATATCTCAAAG	0.423000													33	51					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112769553	112769553	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:112769553G>A	ENST00000390666.3	-	1	1175	c.984C>T	c.(982-984)ccC>ccT	p.P328P	CTD-2201G3.1_ENST00000416046.2_RNA|MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	328					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		CTGTCCCCTCGGGTTTTGTCT	0.612000													8	18					0	0	1	0	0
TKT	7086	broad.mit.edu	37	3	53274270	53274270	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:53274270G>A	ENST00000462138.1	-	4	522	c.434C>T	c.(433-435)gCc>gTc	p.A145V	TKT_ENST00000423525.2_Missense_Mutation_p.A145V|TKT_ENST00000423516.1_Missense_Mutation_p.A145V|TKT_ENST00000296289.6_Missense_Mutation_p.A98V			P29401	TKT_HUMAN	transketolase	145					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			endometrium(5)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	GTGTTACCTGGCCTTGTCGAA	0.607000													5	54					0	0	1	0	0
PAFAH1B2	5049	broad.mit.edu	37	11	117030703	117030703	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:117030703G>T	ENST00000527958.1	+	3	294	c.135G>T	c.(133-135)gtG>gtT	p.V45V	PAFAH1B2_ENST00000419197.2_Silent_p.V45V|PAFAH1B2_ENST00000526888.1_Intron|PAFAH1B2_ENST00000530272.1_Silent_p.V45V|PAFAH1B2_ENST00000529887.2_Silent_p.V45V	NM_002572.3	NP_002563.1	P68402	PA1B2_HUMAN	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	45					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity			kidney(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;1.68e-05)|Epithelial(105;0.000162)|all cancers(92;0.00111)		TACTGTTCGTGGGAGACTCCA	0.403000			T	IGH@	MLCLS								28	88					2.85442e-18	3.14927e-18	1	1	0
GNB2	2783	broad.mit.edu	37	7	100274182	100274182	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100274182T>C	ENST00000303210.4	+	3	564	c.82T>C	c.(82-84)Tca>Cca	p.S28P	GNB2_ENST00000424361.1_5'UTR|GNB2_ENST00000393924.1_Missense_Mutation_p.S28P|GNB2_ENST00000419828.1_Intron|GNB2_ENST00000436220.1_5'UTR|GNB2_ENST00000393926.1_Missense_Mutation_p.S28P|GNB2_ENST00000427895.1_Intron	NM_005273.3	NP_005264.2	P62879	GBB2_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 2	28					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	perinuclear region of cytoplasm|plasma membrane	GTPase activity|GTPase binding|signal transducer activity			endometrium(1)|lung(3)|ovary(2)|prostate(1)	7	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)	Ovarian(593;0.238)				ATGTGGGGACTCAACACTGAC	0.587000													26	33					0	0	1	0	0
DFNB31	25861	broad.mit.edu	37	9	117188502	117188502	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:117188502C>T	ENST00000362057.3	-	4	1323	c.1155G>A	c.(1153-1155)gcG>gcA	p.A385A	DFNB31_ENST00000265134.6_Silent_p.A2A	NM_001173425.1|NM_015404.3	NP_001166896.1|NP_056219.3	Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	385					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTGCCGAGTTCGCCATGGTCT	0.632000													13	22					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56417270	56417270	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:56417270G>A	ENST00000370754.5	-	61	16226	c.16227C>T	c.(16225-16227)gaC>gaT	p.D5409D	DST_ENST00000370769.4_Silent_p.D5231D|DST_ENST00000370788.2_Silent_p.D3143D|DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Silent_p.D2817D|DST_ENST00000361203.3_Silent_p.D5229D|DST_ENST00000421834.2_Silent_p.D3143D|DST_ENST00000446842.2_Silent_p.D4905D			Q03001	DYST_HUMAN	dystonin	5229					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TATTGGCATTGTCATTGCTTG	0.433000													13	25					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19748817	19748817	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19748817G>A	ENST00000203556.4	-	10	976	c.839C>T	c.(838-840)gCg>gTg	p.A280V	GMIP_ENST00000587238.1_Missense_Mutation_p.A280V|GMIP_ENST00000445806.2_Missense_Mutation_p.A280V	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	280					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CTGCTGCCGCGCGTTGGCCTC	0.692000													7	4					0	0	1	0	0
ZNF664	144348	broad.mit.edu	37	12	124497032	124497032	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:124497032C>T	ENST00000539644.1	+	6	2171	c.341C>T	c.(340-342)cCg>cTg	p.P114L	ZNF664_ENST00000337815.4_Missense_Mutation_p.P114L|ZNF664_ENST00000538932.2_Missense_Mutation_p.P114L|RP11-522N14.1_ENST00000540762.1_RNA|ZNF664_ENST00000392404.3_Missense_Mutation_p.P114L			Q8N3J9	ZN664_HUMAN	zinc finger protein 664	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(5)|lung(6)|skin(1)	13	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.000239)|OV - Ovarian serous cystadenocarcinoma(86;0.000247)|all cancers(50;0.00155)|BRCA - Breast invasive adenocarcinoma(302;0.249)		GGTGAGAAACCGTATGTCTGT	0.443000													21	85					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128491585	128491585	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128491585C>T	ENST00000325888.8	+	35	6006	c.5745C>T	c.(5743-5745)acC>acT	p.T1915T	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Silent_p.T1882T	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1915					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GCACCTGCACCGTGTCCTATC	0.597000													20	29					0	0	1	0	0
CD14	929	broad.mit.edu	37	5	140011446	140011446	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140011446C>T	ENST00000302014.6	-	2	1752	c.1123G>A	c.(1123-1125)Gcc>Acc	p.A375T	CD14_ENST00000401743.2_Missense_Mutation_p.A375T	NM_000591.3	NP_000582.1	P08571	CD14_HUMAN	CD14 molecule	375					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATCTTAGGCAAAGCCCCGG	0.582000													10	85					0	0	1	0	0
THPO	7066	broad.mit.edu	37	3	184090552	184090552	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:184090552C>T	ENST00000204615.7	-	6	1025	c.811G>A	c.(811-813)Gcc>Acc	p.A271T	THPO_ENST00000445696.2_Missense_Mutation_p.A267T|THPO_ENST00000421442.2_Missense_Mutation_p.S232N|EIF2B5_ENST00000444495.1_Intron	NM_000460.2|NM_001177597.1|NM_001177598.1	NP_000451.1|NP_001171068.1|NP_001171069.1	P40225	TPO_HUMAN	thrombopoietin	271					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			NS(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATGTCCGGGGCTCCTAGGGTC	0.562000													38	77					0	0	1	0	0
COMMD8	54951	broad.mit.edu	37	4	47455227	47455227	+	Missense_Mutation	SNP	G	G	A	rs77794579	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:47455227G>A	ENST00000381571.4	-	4	447	c.380C>T	c.(379-381)gCa>gTa	p.A127V		NM_017845.3	NP_060315.1	Q9NX08	COMD8_HUMAN	COMM domain containing 8	127	COMM.			A -> L (in Ref. 4; AAH19826).			protein binding			large_intestine(2)|lung(5)|prostate(1)	8						ACTGGAAAGTGCAAGCTGTTT	0.299000													24	28					0	0	1	0	0
HOXA3	3200	broad.mit.edu	37	7	27147884	27147884	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:27147884G>A	ENST00000396352.4	-	3	1181	c.982C>T	c.(982-984)Cgc>Tgc	p.R328C	HOXA3_ENST00000317201.2_Missense_Mutation_p.R328C|HOXA-AS2_ENST00000518088.1_RNA	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	328					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						GCCGTGTAGCGCTTCTGTGGG	0.726000													4	3					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75186962	75186962	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:75186962C>T	ENST00000336926.6	-	16	1603	c.1577G>A	c.(1576-1578)cGg>cAg	p.R526Q	HIP1_ENST00000434438.2_Missense_Mutation_p.R526Q	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	526					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						ACTCACCTTCCGCTGGCCCTG	0.582000			T	PDGFRB	CMML								18	96					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152469194	152469194	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152469194G>A	ENST00000367255.5	-	137	25563	c.24962C>T	c.(24961-24963)gCt>gTt	p.A8321V	SYNE1_ENST00000354674.4_Missense_Mutation_p.A476V|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000539504.1_Missense_Mutation_p.A476V|SYNE1_ENST00000448038.1_Missense_Mutation_p.A8250V|SYNE1_ENST00000356820.4_Missense_Mutation_p.A2845V|SYNE1_ENST00000341594.5_Missense_Mutation_p.A7933V|SYNE1_ENST00000423061.1_Missense_Mutation_p.A8250V|SYNE1_ENST00000265368.4_Missense_Mutation_p.A8321V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8321					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TAAGCCAACAGCTCCCCGGAG	0.493000										HNSCC(10;0.0054)			30	38					0	0	1	0	0
OLFM1	10439	broad.mit.edu	37	9	137990194	137990194	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:137990194C>T	ENST00000252854.4	+	4	652	c.465C>T	c.(463-465)gcC>gcT	p.A155A	OLFM1_ENST00000371793.3_Silent_p.A173A|OLFM1_ENST00000371796.3_Silent_p.A146A	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	173					nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		AGTACAAGGCCGATGCCAAAT	0.453000													23	38					0	0	1	0	0
SENP1	29843	broad.mit.edu	37	12	48482988	48482988	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48482988C>T	ENST00000339976.6	-	5	787	c.405G>A	c.(403-405)agG>agA	p.R135R	SENP1_ENST00000549595.1_Intron|SENP1_ENST00000004980.5_Intron|SENP1_ENST00000549518.1_Intron|SENP1_ENST00000448372.1_Intron|SENP1_ENST00000547886.1_5'UTR|SENP1_ENST00000551330.1_Intron			Q9P0U3	SENP1_HUMAN	SUMO1/sentrin specific peptidase 1	0	Ser-rich.				activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			large_intestine(3)|lung(1)|pancreas(2)|stomach(1)	7		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				CAGCCATGTGCCTTATCTGCA	0.453000													22	51					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14808119	14808119	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:14808119G>A	ENST00000380881.4	-	18	3725	c.2910C>T	c.(2908-2910)ggC>ggT	p.G970G	FREM1_ENST00000380880.3_Silent_p.G969G|FREM1_ENST00000422223.2_Silent_p.G969G			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	969					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AAGGCATCAGGCCAATCTCGC	0.438000													17	23					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76567742	76567742	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:76567742T>C	ENST00000389840.5	-	4	786	c.662A>G	c.(661-663)cAc>cGc	p.H221R	DNAH17_ENST00000585328.1_Missense_Mutation_p.H221R					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGGCAGGGGGTGCAGCCCATC	0.602000													4	64					0	0	1	0	0
UPP2	151531	broad.mit.edu	37	2	158991382	158991382	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:158991382C>T	ENST00000605860.1	+	10	1151	c.1105C>T	c.(1105-1107)Cgg>Tgg	p.R369W	UPP2_ENST00000005756.4_Missense_Mutation_p.R312W|UPP2_ENST00000409859.4_Missense_Mutation_p.R369W|UPP2_ENST00000460456.1_3'UTR			O95045	UPP2_HUMAN	uridine phosphorylase 2	312					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31						CATCAGACGGCGGCTTGGACT	0.493000													19	38					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61868695	61868695	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:61868695G>A	ENST00000280772.1	-	27	3257	c.3066C>T	c.(3064-3066)tgC>tgT	p.C1022C	ANK3_ENST00000373827.2_Silent_p.C1016C|ANK3_ENST00000503366.1_Silent_p.C1023C|ANK3_ENST00000355288.2_Silent_p.C156C	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1022	ZU5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTACCAAACGGCAGGTGATTC	0.567000													14	26					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131927067	131927067	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:131927067G>A	ENST00000378823.3	+	10	2005	c.1187G>A	c.(1186-1188)cGt>cAt	p.R396H	RAD50_ENST00000265335.6_Missense_Mutation_p.R535H	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	535					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACAACAACACGTACCCAAATG	0.378000								Homologous recombination					5	32					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56716397	56716397	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:56716397G>A	ENST00000370754.5	-	4	422	c.423C>T	c.(421-423)tcC>tcT	p.S141S	RP11-472M19.2_ENST00000426453.1_RNA			Q03001	DYST_HUMAN	dystonin	0	Actin-binding.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACGCGTTCCCGGAACTCTACA	0.507000											OREG0017515	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	13					0	0	1	0	0
LRFN3	79414	broad.mit.edu	37	19	36431691	36431691	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36431691G>A	ENST00000588831.1	+	3	2418	c.1364G>A	c.(1363-1365)cGc>cAc	p.R455H	LRFN3_ENST00000246529.3_Missense_Mutation_p.R455H			Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III domain containing 3	455	Fibronectin type-III.				cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane				cervix(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	12	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCGGGCATCCGCATGTACCAG	0.642000													9	5					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201292200	201292200	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:201292200G>A	ENST00000263946.3	+	10	1877	c.1626G>A	c.(1624-1626)tgG>tgA	p.W542*	PKP1_ENST00000367324.3_Nonsense_Mutation_p.W521*|PKP1_ENST00000352845.3_Nonsense_Mutation_p.W542*	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	542					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						GCAGCGGCTGGTTGTACCATT	0.577000													47	55					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103364546	103364546	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:103364546G>T	ENST00000358392.2	-	55	4444	c.4127C>A	c.(4126-4128)cCt>cAt	p.P1376H	COL11A1_ENST00000353414.4_Missense_Mutation_p.P1325H|COL11A1_ENST00000370096.3_Missense_Mutation_p.P1364H|COL11A1_ENST00000512756.1_Missense_Mutation_p.P1248H	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1364	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGCTCCAGGAGGACCCTATAG	0.279000													27	31					2.61193e-14	2.84738e-14	1	1	0
KDM6A	7403	broad.mit.edu	37	X	44937657	44937657	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:44937657C>T	ENST00000377967.4	+	19	2886	c.2845C>T	c.(2845-2847)Cgt>Tgt	p.R949C	KDM6A_ENST00000543216.1_Missense_Mutation_p.R870C|KDM6A_ENST00000536777.1_Missense_Mutation_p.R904C|KDM6A_ENST00000382899.4_Missense_Mutation_p.R956C	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	949					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						GGAAAATAAACGTGATGCTTT	0.323000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								6	32					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92763742	92763742	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:92763742G>A	ENST00000318238.4	-	5	2759	c.1543C>T	c.(1543-1545)Cat>Tat	p.H515Y	SAMD9L_ENST00000437805.1_Missense_Mutation_p.H515Y|SAMD9L_ENST00000411955.1_Missense_Mutation_p.H515Y	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	515										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGCCATAAATGTGGTTCTAGA	0.373000													40	41					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56277092	56277092	+	Missense_Mutation	SNP	G	G	A	rs138562045		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56277092G>A	ENST00000225371.5	+	9	1584	c.1474G>A	c.(1474-1476)Gca>Aca	p.A492T		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	492					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						CCGGGCCTCCGCACCCAACTC	0.602000													18	17					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79514341	79514341	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79514341G>A	ENST00000537152.1	-	5	1839	c.1314C>T	c.(1312-1314)aaC>aaT	p.N438N	C17orf70_ENST00000327787.8_Silent_p.N589N|C17orf70_ENST00000425898.2_Silent_p.N238N	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	589					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CGAGCCCGCCGTTCTCACCAG	0.697000													18	23					0	0	1	0	0
ZNF134	7693	broad.mit.edu	37	19	58131867	58131867	+	Missense_Mutation	SNP	C	C	T	rs80178068		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58131867C>T	ENST00000396161.5	+	3	690	c.380C>T	c.(379-381)cCg>cTg	p.P127L		NM_003435.3	NP_003426.3	P52741	ZN134_HUMAN	zinc finger protein 134	127						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(3)|prostate(1)	11		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		GAACCTCATCCGTCAGAGAAG	0.463000													13	12					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5862915	5862915	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:5862915C>T	ENST00000324989.7	-	3	581	c.493G>A	c.(493-495)Gtt>Att	p.V165I	CRMP1_ENST00000512574.1_Missense_Mutation_p.V49I|CRMP1_ENST00000511535.1_5'UTR|CRMP1_ENST00000397890.2_Missense_Mutation_p.V51I	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	51					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		CCACCAGGAACGATTAAGTTC	0.502000													54	86					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141572638	141572638	+	Silent	SNP	G	G	A	rs149363419	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:141572638G>A	ENST00000220592.5	-	4	544	c.432C>T	c.(430-432)caC>caT	p.H144H	AGO2_ENST00000519980.1_Silent_p.H144H	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		AAAGTGCATCGTGTAACGCCT	0.607000													26	63					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262080	45262080	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:45262080G>T	ENST00000303230.4	-	8	2673	c.2616C>A	c.(2614-2616)tcC>tcA	p.S872S		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	872						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TTAAGACTGAGGAAGATTCTC	0.507000													30	58					3.73148e-12	4.03096e-12	1	1	0
WDR81	124997	broad.mit.edu	37	17	1637344	1637344	+	Silent	SNP	C	C	T	rs146436550		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1637344C>T	ENST00000409644.1	+	7	5013	c.5013C>T	c.(5011-5013)acC>acT	p.T1671T	RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000446363.1_Silent_p.T310T|WDR81_ENST00000545662.1_Silent_p.T302T|WDR81_ENST00000419248.1_Silent_p.T444T|WDR81_ENST00000437219.2_Silent_p.T468T|WDR81_ENST00000309182.5_Silent_p.T620T	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	444										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		AGGATCGTACCGTGCGCCTCT	0.667000													24	24					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38188716	38188716	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:38188716C>A	ENST00000373048.4	-	10	1956	c.1957G>T	c.(1957-1959)Gga>Tga	p.G653*	EPHA10_ENST00000540011.1_Nonsense_Mutation_p.G148*|EPHA10_ENST00000330210.7_Nonsense_Mutation_p.G148*|EPHA10_ENST00000427468.2_Nonsense_Mutation_p.G653*|EPHA10_ENST00000446149.2_5'UTR	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	653	Protein kinase.					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGCTTGCCTCCTCCAAGGCTC	0.617000													14	27					7.93312e-07	8.27737e-07	1	1	0
ANKH	56172	broad.mit.edu	37	5	14769120	14769120	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:14769120C>T	ENST00000284268.6	-	2	607	c.277G>A	c.(277-279)Gca>Aca	p.A93T		NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	93					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						ATGGCCCCTGCCACCACCATA	0.512000													14	24					0	0	1	0	0
HCN3	57657	broad.mit.edu	37	1	155254437	155254437	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155254437G>A	ENST00000368358.3	+	4	986	c.978G>A	c.(976-978)tgG>tgA	p.W326*	HCN3_ENST00000496230.1_3'UTR	NM_020897.1	NP_065948.1	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	326						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCGACGTCTGGCTCACCATGC	0.607000													27	24					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90767697	90767697	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:90767697G>A	ENST00000354366.3	-	7	1663	c.1431C>T	c.(1429-1431)tgC>tgT	p.C477C	NRDE2_ENST00000357904.3_Silent_p.C246C	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		GCAGAAAGTGGCACTGCTGAA	0.512000													12	5					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155744931	155744931	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155744931C>T	ENST00000437809.1	-	17	2334	c.2212G>A	c.(2212-2214)Gcc>Acc	p.A738T	GON4L_ENST00000271883.5_Missense_Mutation_p.A738T|GON4L_ENST00000368331.1_Missense_Mutation_p.A738T|GON4L_ENST00000361040.5_Missense_Mutation_p.A738T|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	738					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TGGTGAAGGGCGATGGAGCTT	0.453000													12	28					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83830445	83830445	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:83830445A>G	ENST00000349129.2	+	10	1294	c.1034A>G	c.(1033-1035)aAc>aGc	p.N345S	DOPEY1_ENST00000536812.1_3'UTR|DOPEY1_ENST00000237163.5_Missense_Mutation_p.N336S|DOPEY1_ENST00000369739.3_Missense_Mutation_p.N336S	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	345					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		GGAGAAGAGAACACTCTAATG	0.363000													11	28					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62290971	62290971	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62290971C>T	ENST00000378024.4	-	5	11192	c.10918G>A	c.(10918-10920)Gtt>Att	p.V3640I	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3640					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GGAACATCAACGTCTACATTG	0.483000													91	134					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50895021	50895021	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50895021G>A	ENST00000380817.2	-	30	4169	c.3986C>T	c.(3985-3987)gCg>gTg	p.A1329V	SBF1_ENST00000476293.1_5'UTR|SBF1_ENST00000348911.6_Missense_Mutation_p.A1304V|SBF1_ENST00000390679.3_Missense_Mutation_p.A1303V	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	1303	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		TGGGGCCAGCGCGTCTCTGCC	0.677000													5	3					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44223605	44223605	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44223605C>T	ENST00000244314.5	+	2	1094	c.895C>T	c.(895-897)Cgt>Tgt	p.R299C		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	299						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				CCACTCACTGCGTGGCTACCA	0.662000													26	46					0	0	1	0	0
PCDHGB1	0	broad.mit.edu	37	5	140731333	140731333	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140731333C>T	ENST00000523390.1	+	1	1506	c.1506C>T	c.(1504-1506)tcC>tcT	p.S502S	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTACGTGTCCGTGAGCCCGC	0.662000													23	46					0	0	1	0	0
CEP290	80184	broad.mit.edu	37	12	88479887	88479887	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:88479887C>T	ENST00000552810.1	-	34	4709	c.4366G>A	c.(4366-4368)Gct>Act	p.A1456T	CEP290_ENST00000547691.2_Missense_Mutation_p.A516T|CEP290_ENST00000397838.3_Missense_Mutation_p.A516T|CEP290_ENST00000309041.7_Missense_Mutation_p.A1458T	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	1456					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						TTCCTTAGAGCGATCTCAAGT	0.348000													10	19					0	0	1	0	0
GEMIN7	0	broad.mit.edu	37	19	45593396	45593396	+	Silent	SNP	C	C	T	rs151025211		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45593396C>T	ENST00000270257.4	+	3	271	c.24C>T	c.(22-24)ccC>ccT	p.P8P	GEMIN7_ENST00000591607.1_Silent_p.P8P|CTB-179K24.3_ENST00000586556.1_RNA|GEMIN7_ENST00000391951.2_Silent_p.P8P|CTB-179K24.4_ENST00000586744.1_RNA|GEMIN7_ENST00000591747.1_Silent_p.P8P	NM_001007269.1|NM_001007270.1|NM_024707.2	NP_001007270.1|NP_001007271.1|NP_078983.1	Q9H840	GEMI7_HUMAN	gem (nuclear organelle) associated protein 7	8					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			endometrium(1)|kidney(1)|lung(4)|ovary(1)	7		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		TGAACATTCCCGTGCCTGTGC	0.572000													36	53					0	0	1	0	0
TMEM138	51524	broad.mit.edu	37	11	61131887	61131887	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61131887C>A	ENST00000542946.1	+	2	224	c.25C>A	c.(25-27)Ctg>Atg	p.L9M	TMEM138_ENST00000540194.1_3'UTR|TMEM138_ENST00000278826.6_Missense_Mutation_p.L9M			Q9NPI0	TM138_HUMAN	transmembrane protein 138	9						integral to membrane				central_nervous_system(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5						TAACTACAGCCTGGTGCTCTC	0.532000													8	52					0.27861	0.27891	1	1	0
CALHM2	51063	broad.mit.edu	37	10	105209329	105209329	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:105209329G>A	ENST00000393235.1	-	3	1567	c.370C>T	c.(370-372)Cgt>Tgt	p.R124C	CALHM2_ENST00000260743.5_Missense_Mutation_p.R124C|CALHM2_ENST00000369788.3_Missense_Mutation_p.R124C			Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	124						integral to membrane				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)|skin(1)	11						GCCTCACCACGCAGCAGGGAG	0.607000													18	26					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64497799	64497799	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:64497799C>T	ENST00000358025.3	+	45	7175	c.6945C>T	c.(6943-6945)tcC>tcT	p.S2315S	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000554584.1_Silent_p.S2315S|SYNE2_ENST00000344113.4_Silent_p.S2315S	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2315					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TAGCAAAATCCGTCAAGCAAA	0.343000													29	57					0	0	1	0	0
DIS3	22894	broad.mit.edu	37	13	73346001	73346001	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:73346001T>C	ENST00000377767.4	-	11	1637	c.1537A>G	c.(1537-1539)Att>Gtt	p.I513V	DIS3_ENST00000377780.4_Missense_Mutation_p.I483V|DIS3_ENST00000545453.1_Missense_Mutation_p.I351V	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	513					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		CCTGGCCTAATAAAATGGCTC	0.333000										Multiple Myeloma(4;0.011)			5	70					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30659555	30659555	+	Silent	SNP	C	C	T	rs112610391		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:30659555C>T	ENST00000534862.1	+	3	456	c.93C>T	c.(91-93)taC>taT	p.Y31Y	HCK_ENST00000518730.1_Silent_p.Y30Y|HCK_ENST00000375862.2_Silent_p.Y51Y|HCK_ENST00000520553.1_Silent_p.Y30Y|HCK_ENST00000375852.2_Silent_p.Y51Y|HCK_ENST00000538448.1_Silent_p.Y30Y	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	51					interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GTCCTGTGTACGTGCCGGATC	0.582000													18	14					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66475239	66475239	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66475239G>A	ENST00000533211.1	-	13	1732	c.1401C>T	c.(1399-1401)caC>caT	p.H467H	SPTBN2_ENST00000309996.2_Silent_p.H467H|SPTBN2_ENST00000529997.1_Silent_p.H467H			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	467					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CAATGGCTTCGTGCTTCCGTA	0.657000													5	36					0	0	1	0	0
C9orf117	286207	broad.mit.edu	37	9	130473655	130473655	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130473655C>T	ENST00000373295.2	+	4	775	c.735C>T	c.(733-735)ggC>ggT	p.G245G		NM_001012502.2	NP_001012520.2	Q5JU67	CI117_HUMAN	chromosome 9 open reading frame 117	245										breast(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	6						CCCAGCAAGGCATGAAGCTGC	0.562000													10	24					0	0	1	0	0
STX8	9482	broad.mit.edu	37	17	9471774	9471774	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:9471774C>T	ENST00000306357.3	-	2	458	c.31G>A	c.(31-33)Gat>Aat	p.D11N	STX8_ENST00000573373.1_Missense_Mutation_p.D11N|STX8_ENST00000574431.1_Intron|STX8_ENST00000573077.3_5'UTR	NM_004853.2	NP_004844.1	Q9UNK0	STX8_HUMAN	syntaxin 8	11					transport	endoplasmic reticulum|integral to plasma membrane		p.D11N(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(1)	12						CAAGTAGAATCGTATGTGGAG	0.403000													17	44					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82450315	82450315	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:82450315G>T	ENST00000370728.1	+	22	3964	c.3319G>T	c.(3319-3321)Ggc>Tgc	p.G1107C	LPHN2_ENST00000359929.3_Missense_Mutation_p.G1094C|LPHN2_ENST00000370730.1_Missense_Mutation_p.G1107C|LPHN2_ENST00000319517.6_Missense_Mutation_p.G1094C|LPHN2_ENST00000335786.5_Missense_Mutation_p.G1107C|LPHN2_ENST00000370723.1_Missense_Mutation_p.G1109C|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000394879.1_Missense_Mutation_p.G1109C|LPHN2_ENST00000370721.1_Missense_Mutation_p.G1032C|LPHN2_ENST00000370713.1_Missense_Mutation_p.G1094C|LPHN2_ENST00000370727.1_Missense_Mutation_p.G1122C|LPHN2_ENST00000370717.2_Missense_Mutation_p.G1122C|LPHN2_ENST00000370715.1_Missense_Mutation_p.G1094C|LPHN2_ENST00000271029.4_Missense_Mutation_p.G1122C|LPHN2_ENST00000370725.1_Missense_Mutation_p.G1122C			O95490	LPHN2_HUMAN	latrophilin 2	1107					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CTGCTGTGGAGGCCTCCCAAC	0.468000													5	88					0.014758	0.0148771	1	1	0
TTLL4	9654	broad.mit.edu	37	2	219618908	219618908	+	Silent	SNP	G	G	A	rs148310172		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219618908G>A	ENST00000392102.1	+	20	3736	c.3396G>A	c.(3394-3396)acG>acA	p.T1132T	TTLL4_ENST00000442769.1_Silent_p.T1068T|TTLL4_ENST00000258398.4_Silent_p.T1132T|TTLL4_ENST00000457313.1_Intron	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	1132					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		ACGGGACCACGCCCAAATCCA	0.493000													47	81					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6610467	6610467	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:6610467C>T	ENST00000433363.2	-	2	344	c.111G>A	c.(109-111)agG>agA	p.R37R	SLC13A5_ENST00000293800.6_Silent_p.R37R|SLC13A5_ENST00000381074.4_Intron|SLC13A5_ENST00000573648.1_Silent_p.R37R	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	37						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						CGTAGGCACACCTGACAAACT	0.572000													9	12					0	0	1	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220363470	220363470	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:220363470T>C	ENST00000358951.2	-	16	1766	c.1650A>G	c.(1648-1650)cgA>cgG	p.R550R		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	550					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		TATCCTTGGCTCGTTCACTCT	0.318000													20	23					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100392853	100392853	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100392853G>A	ENST00000542585.1	+	0	8371				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TCAGAATGACGGGCAGTGTCG	0.627000													6	14					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30131521	30131521	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30131521G>A	ENST00000376694.4	+	1	529	c.60G>A	c.(58-60)gcG>gcA	p.A20A	TRIM15_ENST00000376688.1_Silent_p.A20A	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	20					mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						CCCTCTGTGCGGGGCCGCTGG	0.677000													9	6					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178410056	178410056	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:178410056G>A	ENST00000231188.5	-	9	2469	c.2291C>T	c.(2290-2292)aCg>aTg	p.T764M	GRM6_ENST00000517717.1_Missense_Mutation_p.T764M|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	764					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CACTGTGCACGTGACCATGAG	0.627000													23	27					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72056884	72056884	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:72056884C>T	ENST00000378743.3	-	1	865	c.507G>A	c.(505-507)aaG>aaA	p.K169K	ZFC3H1_ENST00000548100.1_Silent_p.K169K|ZFC3H1_ENST00000552037.1_Silent_p.K169K|THAP2_ENST00000308086.2_5'UTR|ZFC3H1_ENST00000549407.1_5'UTR	NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	169					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						TGCACCCCGGCTTGCCTCCTC	0.657000													31	56					0	0	1	0	0
TKTL1	8277	broad.mit.edu	37	X	153524218	153524218	+	Silent	SNP	G	G	A	rs150445227	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153524218G>A	ENST00000369915.3	+	1	195	c.6G>A	c.(4-6)gcG>gcA	p.A2A	TKTL1_ENST00000217905.7_5'UTR	NM_001145933.1|NM_012253.3	NP_001139405.1|NP_036385.3	P51854	TKTL1_HUMAN	transketolase-like 1	2					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			NS(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(5)|prostate(1)|skin(1)|urinary_tract(2)	34	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GACTAATGGCGGATGCTGAGG	0.597000													8	17					0	0	1	0	0
GDF6	392255	broad.mit.edu	37	8	97156824	97156824	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:97156824C>T	ENST00000287020.5	-	2	1434	c.1335G>A	c.(1333-1335)gaG>gaA	p.E445E		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	445					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					CCACCATGTCCTCGTACTGCT	0.632000													8	9					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12975905	12975905	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12975905C>T	ENST00000251472.4	+	14	1590	c.1551C>T	c.(1549-1551)ggC>ggT	p.G517G		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	517	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CAGATTTCGGCCTCTCCAAGA	0.572000													19	31					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51138419	51138419	+	Missense_Mutation	SNP	G	G	A	rs138370328	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:51138419G>A	ENST00000301180.5	+	38	4562	c.4528G>A	c.(4528-4530)Ggc>Agc	p.G1510S		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	1510						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						GGAACTGTGCGGCTCTGAACA	0.483000													14	101					0	0	1	0	0
hsa-mir-6080	0	broad.mit.edu	37	17	62748014	62748014	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62748014C>A	ENST00000400873.3	-	0	2295					NR_026899.1																						ATTTTGTCTACGCCTCCACAT	0.343000													5	93					1.23904e-05	1.28158e-05	1	1	0
RBFA	79863	broad.mit.edu	37	18	77798609	77798609	+	Silent	SNP	G	G	A	rs143262320	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:77798609G>A	ENST00000306735.5	+	4	621	c.483G>A	c.(481-483)gcG>gcA	p.A161A	RBFA_ENST00000262197.7_Silent_p.A161A|RBFADN_ENST00000569722.1_Intron	NM_024805.2	NP_079081.2	Q8N0V3	RBFA_HUMAN	ribosome binding factor A (putative)	161					rRNA processing	mitochondrion				endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|urinary_tract(1)	15						GAAGTGCCGCGCACATGAGGT	0.498000													6	22					0	0	1	0	0
MEN1	0	broad.mit.edu	37	11	64575422	64575422	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64575422G>A	ENST00000337652.1	-	3	1113	c.610C>T	c.(610-612)Cac>Tac	p.H204Y	MEN1_ENST00000394374.2_Missense_Mutation_p.H204Y|MEN1_ENST00000443283.1_Missense_Mutation_p.H204Y|MEN1_ENST00000394376.1_Missense_Mutation_p.H204Y|MEN1_ENST00000377326.3_Missense_Mutation_p.H199Y|MEN1_ENST00000377313.1_Missense_Mutation_p.H204Y|MEN1_ENST00000377321.1_Intron|MEN1_ENST00000315422.4_Missense_Mutation_p.H199Y|MEN1_ENST00000312049.6_Missense_Mutation_p.H199Y|MEN1_ENST00000377316.2_Missense_Mutation_p.H199Y	NM_130803.2	NP_570715.1	O00255	MEN1_HUMAN	multiple endocrine neoplasia I	204					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						CCCTTGCCGTGCCAGGTGACC	0.632000			"""D, Mis, N, F, S"""		"""parathyroid tumors, Pancreatic neuroendocrine tumors"""	"""parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"""			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated				14	19					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103310685	103310685	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:103310685G>A	ENST00000520539.1	-	26	3965	c.3359C>T	c.(3358-3360)gCt>gTt	p.A1120V	UBR5_ENST00000220959.4_Missense_Mutation_p.A1120V|UBR5_ENST00000521922.1_Missense_Mutation_p.A1114V	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1120					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GCCACTTACAGCTGACATAAA	0.318000													25	31					0	0	1	0	0
ARL6	84100	broad.mit.edu	37	3	97503809	97503809	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:97503809G>T	ENST00000463745.1	+	5	742	c.265G>T	c.(265-267)Gct>Tct	p.A89S	ARL6_ENST00000335979.2_Missense_Mutation_p.A89S|ARL6_ENST00000496713.1_3'UTR|ARL6_ENST00000394206.1_Missense_Mutation_p.A89S	NM_001278293.1	NP_001265222.1	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	89			A -> V (in RP55).		cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding			large_intestine(1)|lung(4)	5		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		AGAAGGCCAAGCTATTATTTT	0.318000													14	34					0.00244969	0.00248438	1	1	0
RP11-1055B8.7	0	broad.mit.edu	37	17	79409833	79409833	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79409833C>T	ENST00000307745.7	+	9	1458	c.1458C>T	c.(1456-1458)agC>agT	p.S486S																								TCCCTAAAAGCGGTCTGGACA	0.677000													5	16					0	0	1	0	0
ANKRD13C	81573	broad.mit.edu	37	1	70771970	70771970	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:70771970G>T	ENST00000370944.4	-	6	1026	c.713C>A	c.(712-714)cCt>cAt	p.P238H	ANKRD13C_ENST00000262346.6_Missense_Mutation_p.P203H	NM_030816.4	NP_110443.3	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	238					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	19						GGAAAGTAAAGGCACTGTATT	0.274000													24	39					7.01153e-11	7.51403e-11	1	1	0
ZNF658	26149	broad.mit.edu	37	9	40774425	40774425	+	Missense_Mutation	SNP	C	C	T	rs144950113	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:40774425C>T	ENST00000602553.1	-	5	1144	c.850G>A	c.(850-852)Gct>Act	p.A284T	ZNF658_ENST00000377626.3_Missense_Mutation_p.A284T|ZNF658_ENST00000441795.1_Missense_Mutation_p.A282T			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	284					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.A284T(1)		breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TATTCAACAGCGGTGGTTTTG	0.388000													53	80					0	0	1	0	0
FBXO36	130888	broad.mit.edu	37	2	230861622	230861622	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:230861622T>G	ENST00000373652.3	+	4	689	c.268T>G	c.(268-270)Tca>Gca	p.S90A	FBXO36_ENST00000409992.1_Missense_Mutation_p.S101A|FBXO36_ENST00000283946.3_Missense_Mutation_p.S121A			Q8NEA4	FBX36_HUMAN	F-box protein 36	121										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(1)	7		Renal(207;0.0112)|all_lung(227;0.0179)|Lung NSC(271;0.0804)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;7.56e-14)|all cancers(144;7.74e-11)|Lung(119;0.00488)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTGTCAAACATCACACAGATT	0.333000													16	108					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141754812	141754812	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:141754812G>A	ENST00000520151.1	-	4	417	c.356C>T	c.(355-357)cCt>cTt	p.P119L	PTK2_ENST00000340930.3_Silent_p.L525L|PTK2_ENST00000521059.1_Silent_p.L525L|PTK2_ENST00000538769.1_Silent_p.L193L|PTK2_ENST00000517887.1_Silent_p.L569L|PTK2_ENST00000522684.1_Silent_p.L525L|PTK2_ENST00000519419.1_Silent_p.L569L|PTK2_ENST00000535192.1_Silent_p.L525L|PTK2_ENST00000519465.1_Silent_p.L153L|PTK2_ENST00000395218.2_Silent_p.L525L			Q05397	FAK1_HUMAN	protein tyrosine kinase 2	0	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TAGGCATACAGGATCAAAGAT	0.343000													56	85					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32239701	32239701	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:32239701G>A	ENST00000400246.1	+	29	2846	c.2704G>A	c.(2704-2706)Gtc>Atc	p.V902I	DEPDC5_ENST00000266091.3_Missense_Mutation_p.V902I|DEPDC5_ENST00000535622.1_Missense_Mutation_p.V824I|DEPDC5_ENST00000400248.1_Missense_Mutation_p.V893I|DEPDC5_ENST00000400249.2_Missense_Mutation_p.V893I|DEPDC5_ENST00000382105.2_Missense_Mutation_p.V824I|DEPDC5_ENST00000382111.2_Missense_Mutation_p.V902I|DEPDC5_ENST00000382112.3_Missense_Mutation_p.V893I			O75140	DEPD5_HUMAN	DEP domain containing 5	893					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CTCAGAGTTCGTCTCCTGCTG	0.498000													28	50					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107589390	107589390	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:107589390C>T	ENST00000374736.3	-	16	2570	c.2176G>A	c.(2176-2178)Gct>Act	p.A726T	ABCA1_ENST00000494467.1_5'UTR	NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	726					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTCACCACAGCAAACACGGAC	0.527000													4	11					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47125634	47125634	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47125634C>T	ENST00000409792.3	-	12	5678	c.5636G>A	c.(5635-5637)cGc>cAc	p.R1879H		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1879					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TTTCAGTCTGCGAAACATTAG	0.443000			"""N, F, S, Mis"""		clear cell renal carcinoma								57	77					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69973026	69973026	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:69973026G>A	ENST00000359154.2	+	22	2541	c.2440_splice	c.e22+1	p.G814_splice	WWP2_ENST00000356003.2_Splice_Site_p.G814_splice|WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000542271.1_Splice_Site_p.G698_splice|WWP2_ENST00000568684.1_Splice_Site_p.G375_splice|WWP2_ENST00000448661.1_Splice_Site_p.G814_splice	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	814	HECT.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CGAACTCATCGGTATGTTTTC	0.607000													8	5					0	0	1	0	0
SIGIRR	59307	broad.mit.edu	37	11	406440	406440	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:406440G>A	ENST00000431843.2	-	9	1284	c.978C>T	c.(976-978)gaC>gaT	p.D326D	SIGIRR_ENST00000382520.2_Silent_p.D326D|SIGIRR_ENST00000397632.3_Silent_p.D326D|SIGIRR_ENST00000531205.1_Silent_p.D326D|SIGIRR_ENST00000332725.3_Silent_p.D326D	NM_001135054.1	NP_001128526.1	Q6IA17	SIGIR_HUMAN	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	326					acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity			cervix(2)|endometrium(1)|liver(1)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	13		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGTCCTTGTCGTCCTGCAGCT	0.642000													20	39					0	0	1	0	0
MYCN	4613	broad.mit.edu	37	2	16086001	16086001	+	Missense_Mutation	SNP	C	C	T	rs104893647		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:16086001C>T	ENST00000281043.3	+	3	1474	c.1177C>T	c.(1177-1179)Cgc>Tgc	p.R393C		NM_005378.4	NP_005369.2	P04198	MYCN_HUMAN	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog	393			R -> H (in MODED).|R -> S (in MODED).		regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			GGAGCGCCAGCGCCGCAACGA	0.572000			A		neuroblastoma								22	39					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21139370	21139370	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:21139370G>A	ENST00000377122.4	-	11	1466	c.1070C>T	c.(1069-1071)aCa>aTa	p.T357I	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	357					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						ATATGATGGTGTCTCAACAAA	0.308000													19	52					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53854688	53854688	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53854688C>T	ENST00000458035.1	+	4	877	c.760C>T	c.(760-762)Caa>Taa	p.Q254*	ZNF845_ENST00000595091.1_Nonsense_Mutation_p.Q254*	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						GGTCTTTAATCAAAAGCGATA	0.388000													23	28					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42331427	42331427	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:42331427C>T	ENST00000217026.4	+	8	1376	c.1249C>T	c.(1249-1251)Cgt>Tgt	p.R417C	MYBL2_ENST00000396863.4_Missense_Mutation_p.R393C	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	417						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.R417C(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GAGGAAGAGGCGTGTGGCTCT	0.617000													13	17					0	0	1	0	0
PARN	5073	broad.mit.edu	37	16	14693776	14693776	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:14693776G>A	ENST00000437198.2	-	12	966	c.825C>T	c.(823-825)caC>caT	p.H275H	PARN_ENST00000539279.1_Silent_p.H100H|PARN_ENST00000420015.2_Silent_p.H229H|PARN_ENST00000341484.7_Silent_p.H214H	NM_001134477.2|NM_002582.3	NP_001127949.1|NP_002573.1	O95453	PARN_HUMAN	poly(A)-specific ribonuclease	275					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|urinary_tract(1)	21						TAGCAATGGCGTGAATGACTC	0.313000													18	26					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60028341	60028341	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:60028341G>A	ENST00000397786.2	-	28	6212	c.6136C>T	c.(6136-6138)Cta>Tta	p.L2046L		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2046					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GTTGATAGTAGCCGATCAGTA	0.383000													28	37					0	0	1	0	0
CCT3	7203	broad.mit.edu	37	1	156279038	156279038	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156279038G>A	ENST00000295688.3	-	14	1870	c.1590C>T	c.(1588-1590)ggC>ggT	p.G530G	CCT3_ENST00000472765.2_Silent_p.G485G|CCT3_ENST00000368261.3_Silent_p.G485G|CCT3_ENST00000368259.2_Silent_p.G492G	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	530					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					TCTGGTCATCGCCTTTCTTTT	0.527000													32	57					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41525896	41525896	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:41525896G>A	ENST00000263253.7	+	5	2390	c.1171G>A	c.(1171-1173)Gca>Aca	p.A391T		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	391					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CTCTTTAGTGGCACACTGTGC	0.348000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				10	41					0	0	1	0	0
INPP4B	8821	broad.mit.edu	37	4	142950057	142950057	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:142950057G>A	ENST00000513000.1	-	27	3086	c.2653C>T	c.(2653-2655)Cgc>Tgc	p.R885C	INPP4B_ENST00000262992.4_Missense_Mutation_p.R885C|INPP4B_ENST00000308502.4_Missense_Mutation_p.R885C|INPP4B_ENST00000508116.1_Missense_Mutation_p.R885C	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	885					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TTCTCTATGCGGCATCCTTCT	0.403000													23	47					0	0	1	0	0
COMMD2	51122	broad.mit.edu	37	3	149470004	149470004	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:149470004G>A	ENST00000473414.1	-	2	192	c.138C>T	c.(136-138)ggC>ggT	p.G46G		NM_016094.3	NP_057178.2	Q86X83	COMD2_HUMAN	COMM domain containing 2	46							protein binding			NS(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	9			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TACTGGCGGCGCCTTCGTAGA	0.567000													42	64					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104922612	104922612	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:104922612G>T	ENST00000262231.10	+	3	1360	c.1112G>T	c.(1111-1113)aGg>aTg	p.R371M	RIMS2_ENST00000507740.1_Intron|RIMS2_ENST00000436393.2_Intron|RIMS2_ENST00000406091.3_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	594					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TCTAACACCAGGTCTGAGAGA	0.413000										HNSCC(12;0.0054)			18	48					3.8784e-16	4.25337e-16	1	1	0
HECTD1	25831	broad.mit.edu	37	14	31613366	31613366	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:31613366T>C	ENST00000399332.1	-	17	3217	c.2729A>G	c.(2728-2730)gAa>gGa	p.E910G	HECTD1_ENST00000553700.1_Missense_Mutation_p.E910G	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	910					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GCTACACATTTCATATGGTGA	0.308000													43	53					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46893139	46893139	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46893139G>T	ENST00000378623.1	-	31	4871	c.4629C>A	c.(4627-4629)gaC>gaA	p.D1543E	LRP4-AS1_ENST00000531719.1_RNA|LRP4-AS1_ENST00000502049.2_RNA	NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1543					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		TCCCATTGAGGTCAGCACTCT	0.557000													10	3					2.80697e-09	2.97546e-09	1	1	0
TLX1	3195	broad.mit.edu	37	10	102894092	102894092	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:102894092G>A	ENST00000370196.6	+	2	2771	c.729G>A	c.(727-729)gcG>gcA	p.A243A	TLX1_ENST00000467928.2_Silent_p.A243A			P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	243						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|upper_aerodigestive_tract(1)	2				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGACCGATGCGCAGGTCAAAA	0.687000			T	"""TRB@, TRD@"""	T-ALL								9	8					0	0	1	0	0
STAMBPL1	57559	broad.mit.edu	37	10	90673111	90673111	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:90673111T>C	ENST00000371927.3	+	6	1632	c.674T>C	c.(673-675)gTa>gCa	p.V225A	STAMBPL1_ENST00000371926.3_Missense_Mutation_p.V225A|STAMBPL1_ENST00000371922.1_Missense_Mutation_p.V59A|STAMBPL1_ENST00000371924.1_Missense_Mutation_p.V225A			Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	225							metal ion binding|metallopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(1)	11		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TTGCTGAATGTATTTGCAGAT	0.468000													44	58					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131140295	131140295	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:131140295G>A	ENST00000357668.1	-	15	1286	c.1259C>T	c.(1258-1260)aCc>aTc	p.T420I	ASAP1_ENST00000518721.1_Missense_Mutation_p.T420I			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	420					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						GAAGGCCATGGTTAGGGCCTC	0.433000													19	25					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33134217	33134217	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:33134217G>A	ENST00000306065.4	-	8	839	c.681C>T	c.(679-681)taC>taT	p.Y227Y	ANKRD27_ENST00000587352.1_Silent_p.Y227Y	NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	227					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					TGGTCCCCACGTATTTAAAGA	0.453000													56	83					0	0	1	0	0
RBBP8	5932	broad.mit.edu	37	18	20562268	20562268	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:20562268C>T	ENST00000399722.2	+	7	867	c.516C>T	c.(514-516)ggC>ggT	p.G172G	RBBP8_ENST00000585177.1_3'UTR|RBBP8_ENST00000327155.5_Silent_p.G172G|RBBP8_ENST00000360790.5_Silent_p.G172G|RBBP8_ENST00000399725.2_Silent_p.G172G	NM_203291.1	NP_976036.1	Q99708	COM1_HUMAN	retinoblastoma binding protein 8	172					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			central_nervous_system(1)|cervix(2)|endometrium(5)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	24	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			CATTTTCTGGCGTTAACCGGC	0.438000								Homologous recombination					17	50					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112666494	112666494	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112666494G>A	ENST00000550722.1	-	42	6598	c.6203C>T	c.(6202-6204)aCa>aTa	p.T2068I	HECTD4_ENST00000377560.5_Missense_Mutation_p.T2042I|HECTD4_ENST00000430131.2_Missense_Mutation_p.T1792I	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		AATAGTCAATGTGTCTGACGC	0.403000													10	45					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008357	120008357	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:120008357C>T	ENST00000341846.5	-	1	804	c.383G>A	c.(382-384)cGc>cAc	p.R128H		NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	128					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		AATGGACTTGCGCAGCTCGCC	0.637000													45	130					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142137378	142137378	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:142137378G>A	ENST00000264951.4	-	12	1431	c.1314C>T	c.(1312-1314)taC>taT	p.Y438Y	XRN1_ENST00000392981.2_Silent_p.Y438Y|XRN1_ENST00000463916.1_Silent_p.Y438Y|XRN1_ENST00000544157.1_Silent_p.Y228Y	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	438					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						TCTTCGTCATGTAATATGTTC	0.303000													6	54					0	0	1	0	0
PTK6	5753	broad.mit.edu	37	20	62163964	62163964	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:62163964C>T	ENST00000217185.2	-	5	774	c.747G>A	c.(745-747)gcG>gcA	p.A249A	PTK6_ENST00000542869.1_Silent_p.A148A	NM_005975.3	NP_005966.1	Q13882	PTK6_HUMAN	protein tyrosine kinase 6	249	Protein kinase.					cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(3)|kidney(1)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	15	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)			CGGCGTACAGCGCCAGGATGT	0.652000													19	26					0	0	1	0	0
TUBBP1	0	broad.mit.edu	37	8	30209642	30209642	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:30209642G>T	ENST00000518096.1	+	0	254																											CACGGGGACAGCGACCTGCAG	0.567000													18	35					5.01169e-05	5.15048e-05	1	1	0
FBLIM1	54751	broad.mit.edu	37	1	16101296	16101296	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16101296G>A	ENST00000441801.2	+	6	1102	c.895G>A	c.(895-897)Gag>Aag	p.E299K	FBLIM1_ENST00000400773.1_Intron|FBLIM1_ENST00000375766.3_Intron|FBLIM1_ENST00000375771.1_Intron|FBLIM1_ENST00000332305.5_Intron	NM_001024215.1	NP_001019386.1	Q8WUP2	FBLI1_HUMAN	filamin binding LIM protein 1	299	LIM zinc-binding 2.|PLEKHC1-binding.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	16		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		CTACAGGTACGAGAAGGGTTT	0.612000													23	38					0	0	1	0	0
GPD1L	23171	broad.mit.edu	37	3	32180128	32180128	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:32180128T>C	ENST00000282541.5	+	3	476	c.275T>C	c.(274-276)gTg>gCg	p.V92A		NM_015141.3	NP_055956.1	Q8N335	GPD1L_HUMAN	glycerol-3-phosphate dehydrogenase 1-like	92					glycerol-3-phosphate catabolic process	glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|NAD binding|protein homodimerization activity			large_intestine(4)|lung(7)|ovary(1)	12						GACCTGCTGGTGTTTGTCATT	0.493000													40	49					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138936733	138936733	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:138936733G>T	ENST00000288561.8	+	3	593	c.344G>T	c.(343-345)cGg>cTg	p.R115L	UBN2_ENST00000473989.2_Missense_Mutation_p.R198L	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	198	Pro-rich.									NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						CGGAAGGATCGGCTACAAGAT	0.383000													32	33					2.87052e-16	3.15041e-16	1	1	0
ALDH6A1	4329	broad.mit.edu	37	14	74534170	74534170	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:74534170C>T	ENST00000553458.1	-	8	1053	c.955G>A	c.(955-957)Gct>Act	p.A319T	ALDH6A1_ENST00000350259.4_Missense_Mutation_p.A306T|AC005484.5_ENST00000492026.1_RNA|CCDC176_ENST00000553773.1_Intron|ALDH6A1_ENST00000555126.1_Missense_Mutation_p.A36T	NM_001278593.1|NM_005589.2	NP_001265522.1|NP_005580.1	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6 family, member A1	319						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(3)|skin(3)	21				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	GTTGAAAGAGCCATGCAGCGC	0.527000													34	57					0	0	1	0	0
HIST1H1T	3010	broad.mit.edu	37	6	26107855	26107855	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:26107855G>A	ENST00000338379.4	-	1	509	c.467C>T	c.(466-468)cCg>cTg	p.P156L		NM_005323.3	NP_005314.2	P22492	H1T_HUMAN	histone cluster 1, H1t	156					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			breast(2)|endometrium(1)|lung(3)|ovary(2)|prostate(1)	9						TGTCGCTCTCGGCTTCTTGGC	0.488000													49	67					0	0	1	0	0
ZNF496	84838	broad.mit.edu	37	1	247492667	247492667	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247492667G>A	ENST00000294753.4	-	3	678	c.214C>T	c.(214-216)Cgg>Tgg	p.R72W	ZNF496_ENST00000366498.2_Missense_Mutation_p.R72W	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	72	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			CTCTCAGGCCGCAGCCAGCCC	0.706000													14	14					0	0	1	0	0
LPAL2	0	broad.mit.edu	37	6	160908419	160908419	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:160908419G>A	ENST00000335388.5	-	0	553					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		AACACCAAGGGCCTGCCGAAC	0.478000													25	38					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84203510	84203510	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:84203510C>T	ENST00000378553.5	+	8	1200	c.1076C>T	c.(1075-1077)gCg>gTg	p.A359V	DNAAF1_ENST00000334315.5_Missense_Mutation_p.A359V|DNAAF1_ENST00000563818.1_3'UTR	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	359					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						CCCGCCAGTGCGGAAGGCAAG	0.537000													14	32					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861456	52861456	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:52861456G>A	ENST00000343457.3	-	4	1738	c.1732C>T	c.(1732-1734)Cct>Tct	p.P578S		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	578						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						GAGAGGGAAGGGTCTAATTCA	0.502000													35	74					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39263574	39263574	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:39263574G>A	ENST00000280481.7	+	1	2309	c.2093G>A	c.(2092-2094)cGc>cAc	p.R698H		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	698					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCTGTGGATCGCCTCCCTCCG	0.557000													30	29					0	0	1	0	0
CES2	8824	broad.mit.edu	37	16	66976084	66976084	+	Missense_Mutation	SNP	C	C	T	rs141601821		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:66976084C>T	ENST00000317091.4	+	9	2390	c.1406C>T	c.(1405-1407)gCg>gTg	p.A469V	CES2_ENST00000417689.1_Missense_Mutation_p.A469V	NM_003869.5	NP_003860.2	O00748	EST2_HUMAN	carboxylesterase 2	405					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		ACCCTCCAAGCGCAGTTCCAG	0.537000													15	24					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841860	13841860	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:13841860C>T	ENST00000265104.4	-	33	5529	c.5425G>A	c.(5425-5427)Gca>Aca	p.A1809T		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1809	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGAATATTTGCGGCTGCCTGG	0.398000									Kartagener syndrome				30	33					0	0	1	0	0
ACKR2	1238	broad.mit.edu	37	3	42906501	42906501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:42906501G>A	ENST00000422265.1	+	3	682	c.507G>A	c.(505-507)tgG>tgA	p.W169*	KRBOX1_ENST00000426937.1_Intron|ACKR2_ENST00000442925.1_Nonsense_Mutation_p.W169*|CYP8B1_ENST00000437102.1_Intron|ACKR2_ENST00000273145.2_Nonsense_Mutation_p.W169*|ACKR2_ENST00000471537.1_Intron	NM_001296.4	NP_001287.2			atypical chemokine receptor 2																		CCATAGTATGGGCTGTGTCCC	0.567000													7	80					0	0	1	0	0
ZNF70	7621	broad.mit.edu	37	22	24086194	24086194	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:24086194C>T	ENST00000341976.3	-	2	1594	c.1134G>A	c.(1132-1134)gcG>gcA	p.A378A		NM_021916.2	NP_068735.1	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	378						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	21						GCTGGATCAGCGCAGAGCTGT	0.582000													28	40					0	0	1	0	0
PBOV1	59351	broad.mit.edu	37	6	138539134	138539134	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:138539134C>T	ENST00000527246.2	-	1	493	c.399G>A	c.(397-399)caG>caA	p.Q133Q	KIAA1244_ENST00000251691.4_Intron	NM_021635.2	NP_067648.1	Q9GZY1	PBOV1_HUMAN	prostate and breast cancer overexpressed 1	133						cytoplasm|nucleus				endometrium(1)	1	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00055)|GBM - Glioblastoma multiforme(68;0.000674)		TTTATATGATCTGTGGATGTA	0.393000													24	28					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81111197	81111197	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:81111197C>T	ENST00000228644.3	+	1	507	c.355C>T	c.(355-357)Ccc>Tcc	p.P119S		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	119	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						CCAGAGGCTGCCCAAGGTGGA	0.587000													23	28					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109691436	109691436	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:109691436C>T	ENST00000277225.5	+	3	5532	c.5243C>T	c.(5242-5244)cCg>cTg	p.P1748L	ZNF462_ENST00000457913.1_Missense_Mutation_p.P1748L|ZNF462_ENST00000441147.2_Missense_Mutation_p.P593L			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1748					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						ATCCCATCCCCGCCCAAGGAC	0.567000													4	30					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28548969	28548969	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:28548969G>A	ENST00000401766.2	-	2	520	c.8C>T	c.(7-9)aCg>aTg	p.T3M	SLC6A4_ENST00000261707.3_Missense_Mutation_p.T3M			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	3					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CAAGGGCGTCGTCTCCATCCT	0.502000													11	37					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84811192	84811192	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:84811192C>T	ENST00000389394.3	+	15	2436	c.2299C>T	c.(2299-2301)Ccc>Tcc	p.P767S	DNAH6_ENST00000237449.6_Missense_Mutation_p.P767S|DNAH6_ENST00000398278.2_Missense_Mutation_p.P767S	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	767	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						ATATCAGGTGCCCACACCTCC	0.393000													32	48					0	0	1	0	0
NAA20	51126	broad.mit.edu	37	20	20007509	20007509	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:20007509G>A	ENST00000398602.2	+	4	850	c.215G>A	c.(214-216)cGa>cAa	p.R72Q	NAA20_ENST00000310450.4_Missense_Mutation_p.R84Q|NAA20_ENST00000334982.4_Missense_Mutation_p.R84Q|NAA20_ENST00000484480.1_3'UTR	NM_181527.3	NP_852668.1	P61599	NAA20_HUMAN	N(alpha)-acetyltransferase 20, NatB catalytic subunit	84	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity	p.R84Q(1)		endometrium(3)|lung(2)|prostate(1)	6						CCAGAATTTCGACGCCTTGGT	0.448000													54	48					0	0	1	0	0
PER1	5187	broad.mit.edu	37	17	8049394	8049394	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8049394T>C	ENST00000317276.4	-	17	2337	c.2100A>G	c.(2098-2100)ggA>ggG	p.G700G	PER1_ENST00000578089.1_5'UTR|PER1_ENST00000354903.5_Silent_p.G684G|PER1_ENST00000581082.1_Silent_p.G680G	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	700	CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TCAGGGTGCCTCCCACCACTG	0.647000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					19	28					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142311642	142311642	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:142311642G>A	ENST00000378004.3	+	11	1414	c.1059G>A	c.(1057-1059)tcG>tcA	p.S353S	ARHGAP26_ENST00000274498.4_Silent_p.S353S	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	353	PH.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGCTTTGTCGGAAGAGGACC	0.502000													19	36					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45169828	45169828	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:45169828C>T	ENST00000429094.2	-	8	1372	c.868G>A	c.(868-870)Ggc>Agc	p.G290S	NELL2_ENST00000452445.2_Missense_Mutation_p.G290S|NELL2_ENST00000437801.2_Missense_Mutation_p.G340S|NELL2_ENST00000395487.2_Missense_Mutation_p.G289S|NELL2_ENST00000333837.4_Missense_Mutation_p.G313S|NELL2_ENST00000549027.1_Missense_Mutation_p.G289S|NELL2_ENST00000551601.1_Missense_Mutation_p.G289S	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	290	VWFC 1.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TTCTTACAGCCGTCTATCCAG	0.418000													11	21					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175722173	175722173	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:175722173C>T	ENST00000443967.1	+	5	1922	c.1515C>T	c.(1513-1515)atC>atT	p.I505I	SIMC1_ENST00000429602.2_Silent_p.I524I|SIMC1_ENST00000430704.2_Silent_p.I90I|SIMC1_ENST00000341199.6_Silent_p.I90I					SUMO-interacting motifs containing 1																		CAAGAGAAATCGTGGCTCACA	0.433000													21	32					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6540483	6540483	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:6540483G>T	ENST00000263125.5	-	5	516	c.417C>A	c.(415-417)ttC>ttA	p.F139L	PRKCQ_ENST00000397176.2_Missense_Mutation_p.F139L|PRKCQ_ENST00000539722.1_Missense_Mutation_p.F14L	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	139					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						GCAAAGCAAAGAAGCCTTCCG	0.502000													10	23					0.000442599	0.000451009	1	1	0
GON4L	54856	broad.mit.edu	37	1	155734786	155734786	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155734786C>T	ENST00000361040.5	-	21	4549	c.4478G>A	c.(4477-4479)aGa>aAa	p.R1493K	GON4L_ENST00000271883.5_Intron|GON4L_ENST00000368331.1_Intron|GON4L_ENST00000437809.1_Intron|GON4L_ENST00000471341.1_5'UTR	NM_032292.4	NP_115668.4	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	0	Glu-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTCTCCAGCTCTCACCTGGAG	0.433000													19	34					0	0	1	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138742168	138742168	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:138742168C>A	ENST00000389532.4	-	6	1012	c.948_splice	c.e6+1	p.K316_splice	CAMSAP1_ENST00000409386.3_Splice_Site_p.K327_splice|CAMSAP1_ENST00000312405.6_Splice_Site_p.K38_splice	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	316	CH.					cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		TCGTTATTACCTTCAACACTA	0.318000													36	37					4.62619e-21	5.13336e-21	1	1	0
SCMH1	22955	broad.mit.edu	37	1	41503052	41503052	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:41503052G>A	ENST00000402904.2	-	13	1998	c.1630C>T	c.(1630-1632)Cgc>Tgc	p.R544C	SCMH1_ENST00000456518.2_Missense_Mutation_p.R386C|SCMH1_ENST00000472037.1_5'UTR|SCMH1_ENST00000397171.2_Missense_Mutation_p.R483C|SCMH1_ENST00000397174.2_Missense_Mutation_p.R524C|SCMH1_ENST00000372595.1_Missense_Mutation_p.R483C|SCMH1_ENST00000372596.1_Missense_Mutation_p.R483C|SCMH1_ENST00000372597.1_Missense_Mutation_p.R497C|SCMH1_ENST00000361705.3_Missense_Mutation_p.R497C|SCMH1_ENST00000361191.5_Missense_Mutation_p.R483C|SCMH1_ENST00000337495.5_Missense_Mutation_p.R554C|SCMH1_ENST00000326197.7_Missense_Mutation_p.R544C	NM_001031694.2	NP_001026864.1	Q96GD3	SCMH1_HUMAN	sex comb on midleg homolog 1 (Drosophila)	544					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(2)|pancreas(2)|upper_aerodigestive_tract(1)	15	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				CATAGCCTGCGCACAGCTGAG	0.597000													18	39					0	0	1	0	0
CEP112	201134	broad.mit.edu	37	17	63898327	63898327	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:63898327G>A	ENST00000392769.2	-	20	2324	c.2106C>T	c.(2104-2106)cgC>cgT	p.R702R	CEP112_ENST00000541355.1_Silent_p.R337R|CEP112_ENST00000537949.1_Silent_p.R660R|CEP112_ENST00000535342.2_Silent_p.R702R	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	702						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						TATTGGCAGCGCGAAGCTGTT	0.408000													33	44					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20807127	20807127	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:20807127A>G	ENST00000359062.3	+	15	3212	c.3172A>G	c.(3172-3174)Aat>Gat	p.N1058D	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	1058	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTGTGAAAATAATGAATCTCC	0.383000													6	41					0	0	1	0	0
TAF6	6878	broad.mit.edu	37	7	99711885	99711885	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99711885G>A	ENST00000472509.1	-	1	296	c.119C>T	c.(118-120)cCg>cTg	p.P40L	TAF6_ENST00000418432.2_5'UTR|TAF6_ENST00000452041.1_5'UTR|TAF6_ENST00000497233.1_5'UTR|TAF6_ENST00000437822.2_Missense_Mutation_p.P20L|TAF6_ENST00000453269.2_5'UTR|TAF6_ENST00000344095.4_5'UTR			P49848	TAF6_HUMAN	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	661					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTGGAGAGACGGAGACCCTGG	0.582000													23	22					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936788	15936788	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:15936788C>T	ENST00000504595.1	+	4	1450	c.969C>T	c.(967-969)tgC>tgT	p.C323C	FBXL7_ENST00000329673.7_Silent_p.C311C|FBXL7_ENST00000510662.1_Silent_p.C276C	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	323					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						TGATCTACTGCGCCTCCATCA	0.667000													4	9					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236195715	236195715	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:236195715C>A	ENST00000264187.6	-	6	1605	c.1523G>T	c.(1522-1524)gGg>gTg	p.G508V	NID1_ENST00000366595.3_Missense_Mutation_p.G508V	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	508	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GATGCTGAACCCATTCTTGAA	0.507000													27	33					1.16021e-09	1.23406e-09	1	1	0
OSBP2	23762	broad.mit.edu	37	22	31289530	31289530	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31289530G>A	ENST00000332585.6	+	10	2175	c.2071G>A	c.(2071-2073)Gtg>Atg	p.V691M	OSBP2_ENST00000382310.3_Missense_Mutation_p.V642M|OSBP2_ENST00000496575.1_3'UTR|OSBP2_ENST00000407373.1_Missense_Mutation_p.V518M|OSBP2_ENST00000535268.1_Missense_Mutation_p.V235M|OSBP2_ENST00000401475.1_Missense_Mutation_p.V324M|OSBP2_ENST00000403222.3_Missense_Mutation_p.V525M|OSBP2_ENST00000446658.2_Missense_Mutation_p.V690M|OSBP2_ENST00000437268.2_Missense_Mutation_p.V433M	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	691					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						CAACATCATCGTGGGCAAGCT	0.632000													16	21					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123725196	123725196	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:123725196C>T	ENST00000223642.1	-	35	4402	c.4373G>A	c.(4372-4374)gGa>gAa	p.G1458E		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1458					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	AATAACATGTCCATCTTTGAT	0.338000													46	90					0	0	1	0	0
RRP7A	27341	broad.mit.edu	37	22	42908986	42908986	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:42908986C>T	ENST00000323013.6	-	7	788	c.773G>A	c.(772-774)cGc>cAc	p.R258H		NM_015703.4	NP_056518.2	Q9Y3A4	RRP7A_HUMAN	ribosomal RNA processing 7 homolog A (S. cerevisiae)	258							nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	10						GAACTTCTTGCGCAGCTGCGC	0.657000													17	22					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	63964619	63964619	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:63964619G>A	ENST00000324472.4	-	20	2102	c.1919C>T	c.(1918-1920)gCc>gTc	p.A640V	DPY19L2_ENST00000413230.2_Missense_Mutation_p.A87V	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	640					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TGTAGGCATGGCACCTGCAAA	0.368000													21	36					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101639889	101639889	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:101639889C>T	ENST00000342239.3	-	16	4390	c.4299G>A	c.(4297-4299)ccG>ccA	p.P1433P	DNMBP_ENST00000324109.4_Silent_p.P1409P|DNMBP_ENST00000543621.1_Silent_p.P655P|DNMBP_ENST00000540316.1_Silent_p.P345P			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1409	Ser-rich.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		ATTCTTTTGGCGGAGGAGATG	0.547000													16	94					0	0	1	0	0
MIB2	142678	broad.mit.edu	37	1	1562801	1562801	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1562801G>A	ENST00000357210.4	+	12	1890	c.1674G>A	c.(1672-1674)acG>acA	p.T558T	MIB2_ENST00000504599.1_Silent_p.T514T|MIB2_ENST00000378712.1_Silent_p.T435T|MIB2_ENST00000520777.1_Silent_p.T611T|MIB2_ENST00000360522.4_Silent_p.T523T|MIB2_ENST00000378708.1_Silent_p.T464T|MIB2_ENST00000505820.2_Silent_p.T615T|MIB2_ENST00000378710.3_Silent_p.T522T|MIB2_ENST00000518681.1_Silent_p.T550T|MIB2_ENST00000355826.5_Silent_p.T601T	NM_080875.2	NP_543151.2	Q96AX9	MIB2_HUMAN	mindbomb E3 ubiquitin protein ligase 2	558					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.T558T(1)		central_nervous_system(1)|endometrium(5)|lung(7)|prostate(4)|upper_aerodigestive_tract(1)	18	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGGGCAACACGGCACTGCACT	0.736000													18	23					0	0	1	0	0
SRI	6717	broad.mit.edu	37	7	87846500	87846500	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:87846500G>A	ENST00000265729.2	-	3	194	c.142C>T	c.(142-144)Cag>Tag	p.Q48*	SRI_ENST00000431660.1_Nonsense_Mutation_p.Q33*|CTB-167B5.1_ENST00000520993.1_RNA|SRI_ENST00000394641.3_Nonsense_Mutation_p.Q33*|SRI_ENST00000490437.1_Nonsense_Mutation_p.Q5*|SRI_ENST00000419179.1_Nonsense_Mutation_p.Q48*	NM_003130.3	NP_003121.1	P30626	SORCN_HUMAN	sorcin	48	EF-hand 1.				heart development|intracellular sequestering of iron ion|muscle organ development|regulation of action potential|regulation of heart contraction|regulation of striated muscle contraction|signal transduction	sarcoplasmic reticulum membrane	calcium channel regulator activity|calcium ion binding|receptor binding			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(14;0.00202)					GCATCTATCTGCCCATCCTTT	0.353000													20	36					0	0	1	0	0
DNAJC18	202052	broad.mit.edu	37	5	138761897	138761897	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:138761897G>T	ENST00000302060.5	-	4	603	c.523C>A	c.(523-525)Ctg>Atg	p.L175M		NM_152686.3	NP_689899.1	Q9H819	DJC18_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 18	175					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACGTTGAACAGCTCTTCTGGA	0.408000													26	54					5.45727e-16	5.98296e-16	1	1	0
ITGA2	3673	broad.mit.edu	37	5	52344197	52344197	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:52344197G>A	ENST00000296585.5	+	5	535	c.392G>A	c.(391-393)tGt>tAt	p.C131Y		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	131					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TTGAAGACATGTGGTCCTCTG	0.423000													20	19					0	0	1	0	0
PADI6	353238	broad.mit.edu	37	1	17727705	17727705	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:17727705G>A	ENST00000434762.2	+	0	1907							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TAACAGTTGCGGATGATTGTG	0.582000													16	15					0	0	1	0	0
NACAP1	0	broad.mit.edu	37	8	102381497	102381497	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:102381497G>A	ENST00000419462.1	+	0	909					NR_002182.1																						TACCTACATGGTTTTTGGGGA	0.418000													20	40					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133150184	133150184	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:133150184A>G	ENST00000388996.4	-	12	2068	c.1648T>C	c.(1648-1650)Tat>Cat	p.Y550H	KCNQ3_ENST00000519445.1_Missense_Mutation_p.Y550H|KCNQ3_ENST00000521134.1_Missense_Mutation_p.Y430H	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	550					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CCGGCAGAATACTGCTCAATC	0.468000													52	77					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10794725	10794725	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:10794725C>T	ENST00000361367.2	+	21	3058	c.2632C>T	c.(2632-2634)Cgg>Tgg	p.R878W		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	878	Lys-rich.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TTTGGAACAGCGGGCCCAGTA	0.413000													25	34					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27835613	27835613	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:27835613C>T	ENST00000318304.8	+	23	2525	c.2242C>T	c.(2242-2244)Cga>Tga	p.R748*	PPFIBP1_ENST00000228425.6_Nonsense_Mutation_p.R742*|PPFIBP1_ENST00000537927.1_Nonsense_Mutation_p.R595*|PPFIBP1_ENST00000542629.1_Nonsense_Mutation_p.R717*	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	748	SAM 2.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					GGTTGATGGTCGAATGCTACA	0.453000													42	49					0	0	1	0	0
MAP7	9053	broad.mit.edu	37	6	136683812	136683812	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:136683812G>T	ENST00000354570.3	-	11	1712	c.1302C>A	c.(1300-1302)gcC>gcA	p.A434A	MAP7_ENST00000438100.2_Silent_p.A419A|MAP7_ENST00000454590.1_Silent_p.A456A|MAP7_ENST00000432797.2_Silent_p.A288A|MAP7_ENST00000544465.1_Silent_p.A419A	NM_001198616.1|NM_001198617.1|NM_001198619.1|NM_003980.4	NP_001185545.1|NP_001185546.1|NP_001185548.1|NP_003971.1	Q14244	MAP7_HUMAN	microtubule-associated protein 7	434	Pro-rich.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(11)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		ctggggccgaggctggagctg	0.572000													9	17					2.52707e-12	2.73248e-12	1	1	0
CDH26	60437	broad.mit.edu	37	20	58571005	58571005	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:58571005G>A	ENST00000348616.4	+	12	2084	c.1784G>A	c.(1783-1785)tGc>tAc	p.C595Y	CDH26_ENST00000244047.5_Missense_Mutation_p.C595Y|CDH26_ENST00000497614.1_3'UTR	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	595					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GTAAGGATCTGCCCCTGTGCC	0.532000													22	27					0	0	1	0	0
MAD1L1	8379	broad.mit.edu	37	7	2259032	2259032	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2259032C>T	ENST00000406869.1	-	6	1088	c.531G>A	c.(529-531)gaG>gaA	p.E177E	MAD1L1_ENST00000265854.7_Silent_p.E177E|MAD1L1_ENST00000402746.1_Silent_p.E85E|MAD1L1_ENST00000399654.2_Silent_p.E177E			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	177					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TCACCCGCATCTCCTGGTCCA	0.632000													14	17					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43822102	43822102	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:43822102T>A	ENST00000389420.3	-	26	3886	c.3887A>T	c.(3886-3888)aAt>aTt	p.N1296I	ADAMTS20_ENST00000395541.2_Missense_Mutation_p.N414I|ADAMTS20_ENST00000553158.1_Missense_Mutation_p.N1296I	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1296						proteinaceous extracellular matrix	zinc ion binding	p.N1296S(1)		breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GACCACCTGATTTTCATTATC	0.423000													41	69					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73020418	73020418	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:73020418T>C	ENST00000263674.3	+	1	1085	c.735T>C	c.(733-735)agT>agC	p.S245S		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	245					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						TCAGCCGCAGTCGTGCTGCCA	0.677000													8	12					0	0	1	0	0
PITX1	5307	broad.mit.edu	37	5	134367190	134367190	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:134367190G>A	ENST00000265340.7	-	2	594	c.178C>T	c.(178-180)Cgc>Tgc	p.R60C	PITX1_ENST00000506438.1_Missense_Mutation_p.R60C	NM_002653.4	NP_002644.4	P78337	PITX1_HUMAN	paired-like homeodomain 1	60						nucleolus	sequence-specific DNA binding			central_nervous_system(1)|cervix(3)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)		TCCCCGCCGCGCTCCTTCTCT	0.721000													10	10					0	0	1	0	0
MOK	5891	broad.mit.edu	37	14	102695636	102695636	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:102695636C>T	ENST00000361847.2	-	12	1481	c.1250G>A	c.(1249-1251)gGc>gAc	p.G417D	MOK_ENST00000519058.1_3'UTR|MOK_ENST00000193029.6_Intron|MOK_ENST00000517966.1_3'UTR|MOK_ENST00000561150.1_Intron|MOK_ENST00000520266.1_5'UTR|MOK_ENST00000523231.1_3'UTR|MOK_ENST00000522874.1_Missense_Mutation_p.G416D|MOK_ENST00000524214.1_Missense_Mutation_p.G387D|MOK_ENST00000522534.1_3'UTR|MOK_ENST00000522867.1_3'UTR|MOK_ENST00000524370.1_3'UTR	NM_014226.1	NP_055041.1	Q9UQ07	MOK_HUMAN	MOK protein kinase	417					signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding										TTATCTTCCGCCTTTCCGCAC	0.582000													15	21					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210560392	210560392	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:210560392C>T	ENST00000360351.4	+	7	4004	c.3498C>T	c.(3496-3498)gcC>gcT	p.A1166A	MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Silent_p.A1162A|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000361559.4_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1166					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	ATGAGATTGCCGTCAAATTGT	0.458000													21	31					0	0	1	0	0
RP11-93K22.13	0	broad.mit.edu	37	3	129810973	129810973	+	RNA	SNP	G	G	A	rs114865400	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:129810973G>A	ENST00000514010.1	-	0	157				ALG1L2_ENST00000507643.1_RNA																							GACACAGAGCGGTCGGCCTTC	0.632000													11	14					0	0	1	0	0
ATF5	22809	broad.mit.edu	37	19	50436130	50436130	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50436130C>T	ENST00000423777.2	+	3	1007	c.630C>T	c.(628-630)cgC>cgT	p.R210R	CTC-326K19.6_ENST00000451973.1_Intron|ATF5_ENST00000595125.1_Silent_p.R210R	NM_001193646.1	NP_001180575.1	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5	210	Interaction with PTP4A1 (By similarity).				regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			NS(1)|endometrium(2)|large_intestine(1)|skin(3)	7		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		GAGGGGACCGCAAGCAAAAGA	0.682000													3	7					0	0	1	0	0
IRAK1BP1	134728	broad.mit.edu	37	6	79607593	79607593	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:79607593C>A	ENST00000369940.2	+	3	534	c.429C>A	c.(427-429)aaC>aaA	p.N143K	IRAK1BP1_ENST00000607739.1_Missense_Mutation_p.N56K	NM_001010844.2	NP_001010844.1	Q5VVH5	IKBP1_HUMAN	interleukin-1 receptor-associated kinase 1 binding protein 1	143					I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(3)	12		all_cancers(76;0.0398)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)		BRCA - Breast invasive adenocarcinoma(397;0.21)		ATATTTGTAACTTTCTTGTTG	0.353000													19	43					1.00905e-13	1.09755e-13	1	1	0
SS18L1	26039	broad.mit.edu	37	20	60733759	60733759	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:60733759G>A	ENST00000331758.3	+	2	127	c.101G>A	c.(100-102)tGc>tAc	p.C34Y	SS18L1_ENST00000421564.1_Missense_Mutation_p.C34Y	NM_198935.1	NP_945173.1	O75177	CREST_HUMAN	synovial sarcoma translocation gene on chromosome 18-like 1	34	N-terminal auto-inhibitory domain; necessary for interaction with SMARCA4/BRG1 (By similarity).				chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome kinetochore			SS18L1/SSX1(2)	ovary(2)|skin(1)	3	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.92e-08)			CTGATCCAGTGCATCCTGGAG	0.627000			T	SSX1	synovial sarcoma								19	19					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101368636	101368636	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:101368636T>C	ENST00000392979.3	+	6	827	c.466T>C	c.(466-468)Tac>Cac	p.Y156H	ANO4_ENST00000299222.9_5'UTR|ANO4_ENST00000538618.1_3'UTR|ANO4_ENST00000392977.3_Missense_Mutation_p.Y191H	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	191						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						AAAAATCTATTACCTGCCCCG	0.463000										HNSCC(74;0.22)			45	62					0	0	1	0	0
COL6A2	0	broad.mit.edu	37	21	47552194	47552194	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:47552194C>T	ENST00000300527.4	+	28	2892	c.2788C>T	c.(2788-2790)Cgc>Tgc	p.R930C		NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	930	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		TGCCATCGTGCGCAGCCCGCG	0.667000													3	1					0	0	1	0	0
FBXO5	26271	broad.mit.edu	37	6	153296250	153296250	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:153296250T>C	ENST00000367241.3	-	2	852	c.472A>G	c.(472-474)Aca>Gca	p.T158A	FBXO5_ENST00000229758.3_Missense_Mutation_p.T204A	NM_001142522.1	NP_001135994.1	Q9UKT4	FBX5_HUMAN	F-box protein 5	204	Interaction with EVI5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm|spindle	metal ion binding|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)	15		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.38e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0893)		TTTTTTAATGTTGAACAAACC	0.373000													34	55					0	0	1	0	0
RFC5	5985	broad.mit.edu	37	12	118454653	118454653	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:118454653G>A	ENST00000454402.2	+	1	139	c.21G>A	c.(19-21)aaG>aaA	p.K7K	RFC5_ENST00000229043.3_5'UTR|RFC5_ENST00000392542.2_5'UTR	NM_001206801.1|NM_007370.5	NP_001193730.1|NP_031396.1	P40937	RFC5_HUMAN	replication factor C (activator 1) 5, 36.5kDa	7					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGCACTCAAGCAGCAGGAGC	0.701000													6	7					0	0	1	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1606354	1606354	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:1606354G>A	ENST00000382171.2	-	1	159	c.126C>T	c.(124-126)tgC>tgT	p.C42C	KRTAP5-AS1_ENST00000532922.1_RNA|KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000424148.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	42	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CGGGCACACAGCAGCTGGAGC	0.682000													40	56					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142606707	142606707	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142606707C>T	ENST00000265310.1	-	14	2192	c.1844G>A	c.(1843-1845)cGc>cAc	p.R615H		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	615					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GATCCCGGAGCGAGGCCACAG	0.597000													12	17					0	0	1	0	0
RASGRP4	115727	broad.mit.edu	37	19	38912645	38912645	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38912645C>T	ENST00000454404.2	-	2	385	c.172G>A	c.(172-174)Gaa>Aaa	p.E58K	RASGRP4_ENST00000587753.1_Missense_Mutation_p.E58K|RASGRP4_ENST00000293062.9_Missense_Mutation_p.E58K|RASGRP4_ENST00000586305.1_Missense_Mutation_p.E58K|RASGRP4_ENST00000426920.2_Missense_Mutation_p.E58K|RASGRP4_ENST00000433821.2_Missense_Mutation_p.E58K|RASGRP4_ENST00000587738.1_Missense_Mutation_p.E58K	NM_001146205.1|NM_170604.2	NP_001139677.1|NP_733749.1	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4	58	N-terminal Ras-GEF.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|prostate(3)|skin(1)	23	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGCTCATCTTCGCTGCAGCCG	0.622000													7	11					0	0	1	0	0
SGK3	23678	broad.mit.edu	37	8	67759502	67759502	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:67759502A>G	ENST00000396596.1	+	15	1363	c.1149A>G	c.(1147-1149)ggA>ggG	p.G383G	SGK3_ENST00000521198.2_Silent_p.G383G|SGK3_ENST00000345714.4_Silent_p.G383G|SGK3_ENST00000522398.1_Silent_p.G383G|SGK3_ENST00000520976.1_Silent_p.G351G|C8orf44-SGK3_ENST00000519289.1_Silent_p.G383G	NM_013257.4	NP_037389.4	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase family, member 3	383	Protein kinase.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	18	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TGAGGCCAGGAGTGAGTCTTA	0.398000													43	58					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203020974	203020974	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:203020974G>A	ENST00000367240.2	+	13	2053	c.1526G>A	c.(1525-1527)cGc>cAc	p.R509H	PPFIA4_ENST00000272198.6_Missense_Mutation_p.R24H|PPFIA4_ENST00000414050.2_Missense_Mutation_p.R237H|PPFIA4_ENST00000599966.1_Missense_Mutation_p.R24H|PPFIA4_ENST00000447715.2_Missense_Mutation_p.R534H|PPFIA4_ENST00000295706.4_Missense_Mutation_p.R24H			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	24	SAM 2.				cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						GTGCATCGCCGCTACTCGGCA	0.637000													7	14					0	0	1	0	0
AKAP8L	26993	broad.mit.edu	37	19	15512317	15512317	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:15512317C>T	ENST00000397410.4	-	5	524	c.460G>A	c.(460-462)Gaa>Aaa	p.E154K	AKAP8L_ENST00000595136.1_Intron|AKAP8L_ENST00000595465.1_Missense_Mutation_p.E93K	NM_014371.2	NP_055186.2	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	154						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11						TAGGCCATTTCCATCTCAGGG	0.612000													10	18					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	65032614	65032614	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:65032614G>A	ENST00000394156.3	-	4	827	c.374C>T	c.(373-375)aCg>aTg	p.T125M	CDH11_ENST00000566827.1_De_novo_Start_InFrame|CDH11_ENST00000268603.4_Missense_Mutation_p.T125M			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	125	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AGCCATCAACGTGTACTGGGC	0.527000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			17	22					0	0	1	0	0
ZNF778	197320	broad.mit.edu	37	16	89293364	89293364	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:89293364G>T	ENST00000433976.2	+	6	916	c.584G>T	c.(583-585)aGa>aTa	p.R195I	RP11-46C24.6_ENST00000563182.1_RNA|ZNF778_ENST00000306502.6_Missense_Mutation_p.R153I	NM_001201407.1|NM_182531.3	NP_001188336.1|NP_872337.2	Q96MU6	ZN778_HUMAN	zinc finger protein 778	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|skin(2)	24				BRCA - Breast invasive adenocarcinoma(80;0.0269)		ACTCGGGACAGATCTCTTGAC	0.478000													4	123					0.00024832	0.000253518	1	1	0
TFE3	7030	broad.mit.edu	37	X	48891660	48891660	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:48891660C>T	ENST00000315869.7	-	6	1251	c.992G>A	c.(991-993)cGg>cAg	p.R331Q	TFE3_ENST00000493583.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	331					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						AGAGATCTCCCGTTTGATGTT	0.562000			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								8	2					0	0	1	0	0
TIRAP	114609	broad.mit.edu	37	11	126162816	126162816	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:126162816C>T	ENST00000392679.1	+	4	795	c.512C>T	c.(511-513)gCc>gTc	p.A171V	TIRAP_ENST00000392678.3_Missense_Mutation_p.A171V|TIRAP_ENST00000392680.2_Missense_Mutation_p.A171V|RP11-712L6.7_ENST00000533378.1_RNA			P58753	TIRAP_HUMAN	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	171	TIR.				3'-UTR-mediated mRNA stabilization|cellular response to bacterial lipopeptide|cellular response to lipoteichoic acid|defense response to Gram-positive bacterium|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|myeloid cell differentiation|negative regulation of growth of symbiont in host|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 1 production|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of ERK1 and ERK2 cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-12 production|positive regulation of interleukin-15 production|positive regulation of interleukin-6 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of JNK cascade|positive regulation of neutrophil chemotaxis|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein homodimerization activity|positive regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|regulation of interferon-beta production|response to lipopolysaccharide|TIRAP-dependent toll-like receptor 4 signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway	endocytic vesicle|intrinsic to membrane|ruffle membrane	phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|protein heterodimerization activity|protein homodimerization activity|protein kinase C delta binding|Toll-like receptor 2 binding|Toll-like receptor 4 binding|transmembrane receptor activity			breast(1)|endometrium(1)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	6	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0739)		GCTCCAGGGGCCGAGGGCTGC	0.647000													3	11					0	0	1	0	0
OR52M1	119772	broad.mit.edu	37	11	4566922	4566922	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:4566922C>T	ENST00000360213.1	+	1	502	c.502C>T	c.(502-504)Cgg>Tgg	p.R168W		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GATCCGCCTGCGGCTGCCCCT	0.517000													40	60					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21562221	21562221	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:21562221G>A	ENST00000382592.4	-	4	2103	c.1698C>T	c.(1696-1698)ggC>ggT	p.G566G	LATS2_ENST00000542899.1_Silent_p.G566G	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	566					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		TATCCTTTCCGCCTTTGTCCC	0.597000													5	117					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53165939	53165939	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53165939G>A	ENST00000332411.2	-	5	1129	c.1076C>T	c.(1075-1077)gCc>gTc	p.A359V		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	359	Coil 2.|Rod.		A -> T (in dbSNP:rs6580904).		cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTCATACTGGGCGCGGACCTC	0.582000													21	21					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100452721	100452721	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:100452721C>T	ENST00000279907.7	-	14	2546	c.2334G>A	c.(2332-2334)gaG>gaA	p.E778E	UHRF1BP1L_ENST00000545232.2_Silent_p.E428E	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	778										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						TTGTCAAAGGCTCAGACTCTG	0.418000													28	86					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156764468	156764468	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156764468G>A	ENST00000271526.4	+	5	1463	c.1191G>A	c.(1189-1191)ctG>ctA	p.L397L	PRCC_ENST00000353233.3_Silent_p.L365L	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	397					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTAAGCGGCTGCAGGGCAAGA	0.473000			T	TFE3	papillary renal								13	19					0	0	1	0	0
TM7SF3	51768	broad.mit.edu	37	12	27127112	27127112	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:27127112G>A	ENST00000343028.4	-	12	1724	c.1499C>T	c.(1498-1500)aCg>aTg	p.T500M	RP11-421F16.3_ENST00000500632.1_RNA	NM_016551.2	NP_057635.1	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3	500						integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	18	Colorectal(261;0.0847)					AATCTGTAACGTAATTCCACT	0.428000													13	38					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202276013	202276013	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:202276013G>A	ENST00000367278.3	+	13	1243	c.1154G>A	c.(1153-1155)cGc>cAc	p.R385H	LGR6_ENST00000439764.2_Missense_Mutation_p.R246H|LGR6_ENST00000308543.3_3'UTR|LGR6_ENST00000255432.7_Missense_Mutation_p.R333H	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	385						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						CAACACAACCGCATCTGGGAA	0.637000													7	18					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1807829	1807829	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1807829G>A	ENST00000340107.4	+	14	2150	c.1894G>A	c.(1894-1896)Gtg>Atg	p.V632M	FGFR3_ENST00000412135.2_Missense_Mutation_p.V518M|FGFR3_ENST00000481110.2_Missense_Mutation_p.V631M|FGFR3_ENST00000440486.2_Missense_Mutation_p.V630M|FGFR3_ENST00000352904.1_Missense_Mutation_p.V518M|FGFR3_ENST00000260795.2_Missense_Mutation_p.V630M	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	630	Protein kinase.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.V630M(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CGAGGACAACGTGATGAAGAT	0.657000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				10	16					0	0	1	0	0
KRT7	3855	broad.mit.edu	37	12	52629021	52629021	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:52629021G>A	ENST00000331817.5	+	2	590	c.407G>A	c.(406-408)cGc>cAc	p.R136H		NM_005556.3	NP_005547.3	P08729	K2C7_HUMAN	keratin 7	136	Linker 1.|Rod.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(357;0.105)		AAGAGCAGCCGCCTCCCAGAC	0.637000													13	32					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19339180	19339180	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19339180G>A	ENST00000252575.5	+	8	2794	c.2751G>A	c.(2749-2751)ccG>ccA	p.P917P	NCAN_ENST00000538881.1_Silent_p.P368P	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	917					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			CAGTGCCTCCGCATCAGAGCA	0.617000													24	55					0	0	1	0	0
KCNA7	3743	broad.mit.edu	37	19	49573733	49573733	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49573733A>G	ENST00000221444.1	-	2	1313	c.958T>C	c.(958-960)Ttc>Ctc	p.F320L		NM_031886.2	NP_114092.2	Q96RP8	KCNA7_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 7	320						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|skin(2)	11		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000397)|OV - Ovarian serous cystadenocarcinoma(262;0.000519)|GBM - Glioblastoma multiforme(486;0.00541)|Epithelial(262;0.0441)		ACACCGATGAAGAGGAAAAAG	0.582000													4	9					0	0	1	0	0
MED26	9441	broad.mit.edu	37	19	16687136	16687136	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16687136G>A	ENST00000263390.3	-	3	1767	c.1505C>T	c.(1504-1506)gCg>gTg	p.A502V	CTD-3222D19.2_ENST00000409035.1_Intron	NM_004831.3	NP_004822.2	O95402	MED26_HUMAN	mediator complex subunit 26	502					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	8						TGGGGTCTGCGCGCCCGATGA	0.617000													19	19					0	0	1	0	0
FBXL19	54620	broad.mit.edu	37	16	30958065	30958065	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30958065C>T	ENST00000338343.4	+	10	2029	c.1642C>T	c.(1642-1644)Cgt>Tgt	p.R548C	FBXL19_ENST00000380310.2_Missense_Mutation_p.R568C|FBXL19_ENST00000562319.1_Missense_Mutation_p.R548C|FBXL19_ENST00000471231.2_Missense_Mutation_p.R256C|FBXL19_ENST00000565690.1_Missense_Mutation_p.R432C			Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	568							DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						AACAGAGAGCCGTGGTCGGCT	0.652000													4	10					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155199255	155199255	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:155199255G>A	ENST00000460012.1	-	23	4827	c.4470C>T	c.(4468-4470)ggC>ggT	p.G1490G	PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000414191.1_Silent_p.G1490G|PLCH1_ENST00000340059.7_Silent_p.G1528G|PLCH1_ENST00000334686.6_Silent_p.G1490G			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1528					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity	p.G1490G(1)		NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCACAGTCACGCCCTTCTTGT	0.463000													20	70					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105411328	105411328	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105411328G>A	ENST00000333244.5	-	7	10579	c.10460C>T	c.(10459-10461)gCc>gTc	p.A3487V	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3487						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTGCCTGGGGCCGACACCCC	0.622000													98	164					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19345871	19345871	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:19345871G>A	ENST00000261537.6	+	2	632	c.368G>A	c.(367-369)cGc>cAc	p.R123H	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	123					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			TTAAGACATCGCTTTTACCGA	0.408000													13	77					0	0	1	0	0
ARMC6	93436	broad.mit.edu	37	19	19162543	19162543	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19162543C>T	ENST00000535612.1	+	5	824	c.392C>T	c.(391-393)gCg>gTg	p.A131V	ARMC6_ENST00000546344.1_Missense_Mutation_p.A38V|ARMC6_ENST00000392335.2_Missense_Mutation_p.A106V|ARMC6_ENST00000269932.6_Missense_Mutation_p.A106V|ARMC6_ENST00000392336.3_Missense_Mutation_p.A131V	NM_001199196.1	NP_001186125.1	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	131							protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|prostate(1)	14			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			CGCTTCCTCGCGGCCCAGAAG	0.642000													14	20					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65393124	65393124	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65393124G>A	ENST00000355703.3	+	19	3676	c.3135_splice	c.e19-1	p.R1046_splice		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1046						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						GCCCTGCAGCGTGAGGTCTTG	0.622000													4	14					0	0	1	0	0
EBI3	10148	broad.mit.edu	37	19	4234688	4234688	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4234688T>G	ENST00000221847.5	+	4	457	c.404T>G	c.(403-405)gTg>gGg	p.V135G		NM_005755.2	NP_005746.2	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3	135	Fibronectin type-III 2.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGAAGGCGTGCGCCTAAGC	0.577000													29	49					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136700842	136700842	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:136700842C>T	ENST00000445907.2	+	3	1758	c.1230C>T	c.(1228-1230)aaC>aaT	p.N410N	AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000425981.2_RNA|CHRM2_ENST00000402486.3_Silent_p.N410N|AC009264.1_ENST00000598184.1_RNA|CHRM2_ENST00000397608.3_Silent_p.N410N|CHRM2_ENST00000401861.1_Silent_p.N410N|AC009264.1_ENST00000593789.1_RNA|AC009264.1_ENST00000439694.1_RNA|CHRM2_ENST00000320658.5_Silent_p.N410N|CHRM2_ENST00000453373.1_Silent_p.N410N	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	410					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	TGCTCATTAACACCTTTTGTG	0.473000													4	106					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50720614	50720614	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50720614G>A	ENST00000449103.1	-	19	3256	c.3117_splice	c.e19+1	p.T1039_splice	PLXNB2_ENST00000359337.4_Splice_Site_p.T1039_splice			O15031	PLXB2_HUMAN	plexin B2	1039	IPT/TIG 3.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGGACTGACCGTCATGGGCTG	0.692000													12	13					0	0	1	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151247370	151247370	+	Missense_Mutation	SNP	C	C	T	rs151023222		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:151247370C>T	ENST00000367321.3	+	11	1469	c.1195C>T	c.(1195-1197)Cgt>Tgt	p.R399C		NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	399	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		AGCCAAAGTACGTTTGTCCGT	0.413000													42	50					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4016805	4016805	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4016805G>A	ENST00000294016.3	-	11	3571	c.3033C>T	c.(3031-3033)gaC>gaT	p.D1011D		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	1011					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CCGCTTCCACGTCTCCGTGGT	0.572000													35	59					0	0	1	0	0
CALM1	801	broad.mit.edu	37	14	90870762	90870762	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:90870762G>A	ENST00000356978.4	+	5	573	c.325G>A	c.(325-327)Gtc>Atc	p.V109I	RP11-471B22.2_ENST00000555853.1_RNA|CALM1_ENST00000544280.2_Missense_Mutation_p.V73I|CALM1_ENST00000447653.3_Missense_Mutation_p.V110I|CALM1_ENST00000553542.1_Missense_Mutation_p.V73I	NM_006888.4	NP_008819.1	P62158	CALM_HUMAN	calmodulin 1 (phosphorylase kinase, delta)	109	EF-hand 3.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(1)	10		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.208)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	ACTACGTCACGTCATGACAAA	0.393000													22	34					0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1834632	1834632	+	Missense_Mutation	SNP	G	G	A	rs144099418		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1834632G>A	ENST00000302787.2	-	6	1215	c.919C>T	c.(919-921)Cgt>Tgt	p.R307C		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	307	LETM1.				cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			TTGGAAAAACGCATGATTTCC	0.602000													25	49					0	0	1	0	0
PTGER2	5732	broad.mit.edu	37	14	52782026	52782026	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:52782026G>A	ENST00000245457.5	+	1	914	c.760G>A	c.(760-762)Gtg>Atg	p.V254M	PTGER2_ENST00000557436.1_5'UTR	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	254						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	AGGGGAAAGGGTGTCCATGGC	0.657000													4	25					0	0	1	0	0
AP1G2	8906	broad.mit.edu	37	14	24033829	24033829	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24033829G>A	ENST00000308724.5	-	8	1618	c.863C>T	c.(862-864)gCg>gTg	p.A288V	AP1G2_ENST00000556277.1_5'UTR|AP1G2_ENST00000397120.3_Missense_Mutation_p.A288V|RP11-66N24.3_ENST00000555968.1_RNA	NM_003917.2	NP_003908.1	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2 subunit	288					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	28	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		AAACAGGACCGCATTTCCGGC	0.562000													26	29					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93127645	93127645	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:93127645G>A	ENST00000298050.3	+	10	1162	c.1062G>A	c.(1060-1062)caG>caA	p.Q354Q	CCDC67_ENST00000525646.1_Silent_p.Q96Q	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	354										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				AACTCCAACAGGTGGAAGAGT	0.383000													3	7					0	0	1	0	0
FN3KRP	79672	broad.mit.edu	37	17	80678199	80678199	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80678199G>A	ENST00000269373.6	+	3	418	c.345G>A	c.(343-345)aaG>aaA	p.K115K	FN3KRP_ENST00000535965.1_Silent_p.K65K	NM_024619.3	NP_078895.2	Q9HA64	KT3K_HUMAN	fructosamine 3 kinase related protein	115							kinase activity			breast(1)|large_intestine(2)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	7	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			TTGATAACAAGAAGCTTGGAG	0.562000													26	46					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31434701	31434701	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31434701C>T	ENST00000389202.2	+	25	2937	c.2888C>T	c.(2887-2889)gCc>gTc	p.A963V		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	963					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CGAGATCTGGCCATCAGCATT	0.547000													16	30					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16945623	16945623	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16945623G>A	ENST00000412962.1	-	0	1896																											GGGACAAAGGGCTTGGGGGAT	0.612000													17	234					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65342334	65342334	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:65342334G>A	ENST00000402939.2	-	23	4107	c.4108C>T	c.(4108-4110)Cgg>Tgg	p.R1370W	MAGI1_ENST00000330909.8_3'UTR	NM_001033057.1	NP_001028229.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1399					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GACCGTCTCCGCCGGCTGGGG	0.697000													12	45					0	0	1	0	0
FBXO6	26270	broad.mit.edu	37	1	11733379	11733379	+	Silent	SNP	G	G	C	rs150995826	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11733379G>C	ENST00000376753.4	+	5	690	c.555G>C	c.(553-555)gtG>gtC	p.V185V		NM_018438.5	NP_060908.1	Q9NRD1	FBX6_HUMAN	F-box protein 6	185	FBA.				DNA damage checkpoint|DNA repair|ER-associated protein catabolic process|response to unfolded protein|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	glycoprotein binding			breast(1)|large_intestine(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(2)	6	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.25e-06)|COAD - Colon adenocarcinoma(227;0.000251)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		AACTCAAAGTGCAGCTGGCCT	0.622000													4	17					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2983405	2983405	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:2983405G>A	ENST00000342628.2	-	2	353	c.240C>T	c.(238-240)aaC>aaT	p.N80N	FOXM1_ENST00000361953.3_Silent_p.N80N|FOXM1_ENST00000359843.3_Silent_p.N80N	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	80					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TATTAGCATTGTTGGGGATGG	0.507000													25	40					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183689508	183689508	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:183689508C>T	ENST00000334444.6	-	11	1844	c.1604G>A	c.(1603-1605)cGc>cAc	p.R535H	ABCC5_ENST00000265586.6_Missense_Mutation_p.R535H	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	535						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity	p.R535L(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ATGCTCAGTGCGCTGCAGCTG	0.582000													6	34					0	0	1	0	0
CAMKK2	10645	broad.mit.edu	37	12	121712246	121712246	+	Silent	SNP	G	G	A	rs146079022		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:121712246G>A	ENST00000324774.5	-	2	912	c.84C>T	c.(82-84)agC>agT	p.S28S	CAMKK2_ENST00000538733.1_Silent_p.S28S|CAMKK2_ENST00000412367.2_Silent_p.S28S|CAMKK2_ENST00000337174.3_Silent_p.S28S|CAMKK2_ENST00000446440.2_Silent_p.S28S|CAMKK2_ENST00000402834.4_Silent_p.S28S|CAMKK2_ENST00000535524.1_5'UTR|CAMKK2_ENST00000392474.2_Silent_p.S28S|CAMKK2_ENST00000347034.2_Silent_p.S28S|CAMKK2_ENST00000404169.3_Silent_p.S28S|CAMKK2_ENST00000392473.2_Silent_p.S28S	NM_006549.3	NP_006540.3	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase kinase 2, beta	28					calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	17	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCTGGCTTTCGCTGCTGCTGC	0.647000													9	7					0	0	1	0	0
SLC2A7	155184	broad.mit.edu	37	1	9067389	9067389	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:9067389G>A	ENST00000400906.1	-	10	1171	c.1172C>T	c.(1171-1173)gCg>gTg	p.A391V		NM_207420.2	NP_997303.2	Q6PXP3	GTR7_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 7	391						integral to membrane|plasma membrane	sugar transmembrane transporter activity			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|lung(4)|prostate(2)|skin(2)	24	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		GGAATGTCCCGCGATGTAGGC	0.627000													11	17					0	0	1	0	0
YWHAQ	10971	broad.mit.edu	37	2	9731520	9731520	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:9731520C>T	ENST00000381844.4	-	2	582		c.e2+1		YWHAQ_ENST00000238081.3_Splice_Site|YWHAQ_ENST00000474715.1_Splice_Site			P27348	1433T_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide						negative regulation of transcription, DNA-dependent	centrosome|nucleus	protein N-terminus binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.241)		AATAAACTTACGTTTTCGATC	0.383000													14	31					0	0	1	0	0
PUS7	54517	broad.mit.edu	37	7	105148785	105148785	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:105148785G>A	ENST00000356362.2	-	2	389	c.175C>T	c.(175-177)Cct>Tct	p.P59S	PUS7_ENST00000469408.1_Missense_Mutation_p.P59S	NM_019042.3	NP_061915.2	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)	59					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						GGAGGCCGAGGCACGTCTTCA	0.478000													41	65					0	0	1	0	0
NUP62	23636	broad.mit.edu	37	19	50412681	50412681	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50412681G>A	ENST00000596217.1	-	2	2271	c.384C>T	c.(382-384)acC>acT	p.T128T	NUP62_ENST00000597029.1_Silent_p.T128T|IL4I1_ENST00000595948.1_Intron|NUP62_ENST00000422090.2_Silent_p.T128T|NUP62_ENST00000597723.1_Silent_p.T128T|NUP62_ENST00000413454.1_Silent_p.T128T|NUP62_ENST00000352066.3_Silent_p.T128T|IL4I1_ENST00000341114.3_Intron			P37198	NUP62_HUMAN	nucleoporin 62kDa	128	15 X 9 AA approximate repeats.|Thr-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|stomach(1)|urinary_tract(2)	19		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TGGAGGTGACGGTGCTCGATA	0.597000													18	31					0	0	1	0	0
AMIGO3	386724	broad.mit.edu	37	3	49755492	49755492	+	Missense_Mutation	SNP	C	C	A	rs149938600		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49755492C>A	ENST00000535833.1	-	10	4857	c.1407G>T	c.(1405-1407)caG>caT	p.Q469H	GMPPB_ENST00000480687.1_3'UTR|AMIGO3_ENST00000320431.7_Missense_Mutation_p.Q469H|RNF123_ENST00000327697.6_Intron|RNF123_ENST00000433785.1_Intron			Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	469					heterophilic cell-cell adhesion	integral to membrane				endometrium(1)|pancreas(1)|prostate(2)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTACTGCCAGCTGCACGCGGC	0.637000													22	39					8.04996e-18	8.87193e-18	1	1	0
DKFZP761J1410	0	broad.mit.edu	37	19	11474850	11474850	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11474850G>A	ENST00000251473.5	+	9	1337	c.961G>A	c.(961-963)Gca>Aca	p.A321T	DKFZP761J1410_ENST00000591608.1_Missense_Mutation_p.C301Y	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					CCCGAGGTCTGCAGGCCGCAT	0.652000													30	61					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89522750	89522750	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:89522750G>A	ENST00000370473.4	-	7	1161	c.942C>T	c.(940-942)aaC>aaT	p.N314N		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	314					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		CCAGGACTGCGTTCTCCATGC	0.532000													22	35					0	0	1	0	0
EPC1	80314	broad.mit.edu	37	10	32576142	32576142	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:32576142G>A	ENST00000319778.6	-	7	1338	c.1036C>T	c.(1036-1038)Cca>Tca	p.P346S	EPC1_ENST00000263062.8_Missense_Mutation_p.P346S|EPC1_ENST00000375110.2_Missense_Mutation_p.P296S	NM_001272004.1|NM_001272019.1	NP_001258933.1|NP_001258948.1	Q9H2F5	EPC1_HUMAN	enhancer of polycomb homolog 1 (Drosophila)	346					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(5)|urinary_tract(1)	24		Prostate(175;0.0199)				GCAGACGATGGTAAGACTTTG	0.448000													45	46					0	0	1	0	0
CHRNB1	1140	broad.mit.edu	37	17	7351905	7351905	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7351905C>T	ENST00000306071.2	+	7	685	c.618C>T	c.(616-618)ggC>ggT	p.G206G	CHRNB1_ENST00000536404.2_Silent_p.G134G|CHRNB1_ENST00000576360.1_Silent_p.G134G	NM_000747.2	NP_000738.2	P11230	ACHB_HUMAN	cholinergic receptor, nicotinic, beta 1 (muscle)	206					behavioral response to nicotine|muscle contraction|muscle fiber development|neuromuscular synaptic transmission|postsynaptic membrane organization|regulation of membrane potential|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine binding|receptor activity			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|ovary(3)	23		Prostate(122;0.157)				CAGAGAATGGCCAGTGGGAGA	0.572000													7	9					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32204494	32204494	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32204494C>T	ENST00000373658.3	-	16	2881	c.2540G>A	c.(2539-2541)cGc>cAc	p.R847H	BAI2_ENST00000398538.1_Missense_Mutation_p.R835H|BAI2_ENST00000527361.1_Missense_Mutation_p.R847H|BAI2_ENST00000373655.2_Missense_Mutation_p.R847H|BAI2_ENST00000398542.1_Missense_Mutation_p.R780H|BAI2_ENST00000440175.2_Missense_Mutation_p.R489H|BAI2_ENST00000398556.3_Missense_Mutation_p.R795H|BAI2_ENST00000398547.1_Missense_Mutation_p.R780H|BAI2_ENST00000257070.4_Missense_Mutation_p.R847H	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	847					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GGTAGGGGGGCGCACAGTCAC	0.627000													18	62					0	0	1	0	0
LIPG	9388	broad.mit.edu	37	18	47093932	47093932	+	Missense_Mutation	SNP	G	G	A	rs144530815		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:47093932G>A	ENST00000261292.4	+	3	678	c.400G>A	c.(400-402)Gcg>Acg	p.A134T	LIPG_ENST00000577628.1_Missense_Mutation_p.A170T|LIPG_ENST00000580036.1_Missense_Mutation_p.A134T|LIPG_ENST00000427224.2_Missense_Mutation_p.A134T	NM_006033.2	NP_006024.1	Q9Y5X9	LIPE_HUMAN	lipase, endothelial	134					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(2)	18						TTACACGGATGCGGTCAATAA	0.572000													16	22					0	0	1	0	0
WNT6	7475	broad.mit.edu	37	2	219738492	219738492	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219738492G>A	ENST00000233948.3	+	4	1240	c.1023G>A	c.(1021-1023)ctG>ctA	p.L341L		NM_006522.3	NP_006513.1	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family, member 6	341					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			large_intestine(1)|ovary(2)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGAACTGCCTGTGCCGCTTCC	0.697000													11	4					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83259056	83259056	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:83259056C>T	ENST00000296591.5	-	10	1679	c.1261G>A	c.(1261-1263)Gta>Ata	p.V421I	EDIL3_ENST00000380138.3_Missense_Mutation_p.V411I	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	421	F5/8 type C 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TCCTGGTATACAGTCCAGTGT	0.393000													10	79					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85611673	85611673	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:85611673C>T	ENST00000322366.6	-	60	9705	c.9298G>A	c.(9298-9300)Gtc>Atc	p.V3100I	WDFY3_ENST00000295888.4_Missense_Mutation_p.V3117I			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3117						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTGAGGGTGACGGTCTTGGCC	0.498000													15	31					0	0	1	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123650019	123650019	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:123650019C>T	ENST00000606320.1	-	18	2803	c.2597G>A	c.(2596-2598)cGt>cAt	p.R866H	MPHOSPH9_ENST00000392425.3_Missense_Mutation_p.R714H|MPHOSPH9_ENST00000302349.5_Missense_Mutation_p.R714H|MPHOSPH9_ENST00000541076.2_Missense_Mutation_p.R836H			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	714					M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		CAGAGGTGAACGGTGCCTTAA	0.423000													5	74					0	0	1	0	0
BCOR	54880	broad.mit.edu	37	X	39930266	39930266	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:39930266G>T	ENST00000342274.4	-	6	3560	c.3198C>A	c.(3196-3198)acC>acA	p.T1066T	BCOR_ENST00000378444.4_Silent_p.T1066T|BCOR_ENST00000378455.4_Silent_p.T1048T|BCOR_ENST00000397354.3_Silent_p.T1066T	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	1066					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						CCTCCTCCAGGGTGACCGACT	0.517000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						21	8					2.48779e-11	2.67617e-11	1	1	0
F13B	2165	broad.mit.edu	37	1	197009752	197009752	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:197009752C>A	ENST00000367412.1	-	11	1895	c.1852G>T	c.(1852-1854)Gga>Tga	p.G618*	F13B_ENST00000490002.1_5'UTR	NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	618	Sushi 10.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TAAGTATCTCCTCTACAAATA	0.313000													15	24					3.35478e-16	3.68069e-16	1	1	0
OSR2	116039	broad.mit.edu	37	8	99961116	99961116	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:99961116G>A	ENST00000457907.2	+	3	464	c.299G>A	c.(298-300)cGc>cAc	p.R100H	OSR2_ENST00000522510.1_5'UTR|OSR2_ENST00000297565.4_5'UTR|OSR2_ENST00000523368.1_5'UTR|OSR2_ENST00000435298.2_5'UTR			Q8N2R0	OSR2_HUMAN	odd-skipped related transciption factor 2	0					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			GGAGCCCCACGCCCTCCGGCC	0.587000													8	11					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81236213	81236213	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:81236213C>T	ENST00000599697.1	-	6	1034	c.1035G>A	c.(1033-1035)acG>acA	p.T345T	PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000337114.4_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	345					neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TCACACTGAGCGTCTCCATCT	0.577000													22	25					0	0	1	0	0
IBTK	25998	broad.mit.edu	37	6	82922423	82922423	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:82922423C>T	ENST00000306270.7	-	13	2841		c.e13+1		IBTK_ENST00000503631.1_Splice_Site|IBTK_ENST00000510291.1_Splice_Site	NM_015525.2	NP_056340.2	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton agammaglobulinemia tyrosine kinase						negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TCCTTACTTACCATTTTTTCT	0.333000													4	25					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213921699	213921699	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:213921699G>A	ENST00000457361.1	-	4	432	c.264C>T	c.(262-264)agC>agT	p.S88S	IKZF2_ENST00000421754.2_Silent_p.S88S|IKZF2_ENST00000374327.4_Intron|IKZF2_ENST00000434687.1_Silent_p.S88S|IKZF2_ENST00000342002.2_Silent_p.S94S|IKZF2_ENST00000451136.2_Silent_p.S88S|IKZF2_ENST00000413091.3_Silent_p.S88S|IKZF2_ENST00000374319.4_Silent_p.S88S	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CAGCCACCTCGCTGCTCTCAA	0.527000													22	34					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200953989	200953989	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:200953989G>C	ENST00000332129.2	-	27	4117	c.3801C>G	c.(3799-3801)gaC>gaG	p.D1267E	KIF21B_ENST00000422435.2_Missense_Mutation_p.D1267E|KIF21B_ENST00000461742.2_Missense_Mutation_p.D1267E|KIF21B_ENST00000360529.5_Missense_Mutation_p.D1267E	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1267					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CTGCTTACTTGTCCAGCGCTG	0.622000													15	15					0	0	1	0	0
KRBA2	124751	broad.mit.edu	37	17	8273378	8273378	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8273378G>A	ENST00000396267.1	-	2	1138	c.307C>T	c.(307-309)Cgg>Tgg	p.R103W	RP11-849F2.5_ENST00000583963.1_RNA|RP11-849F2.7_ENST00000582471.1_3'UTR|RP11-849F2.5_ENST00000580537.1_RNA|KRBA2_ENST00000331336.2_Missense_Mutation_p.R185W			Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	185	KRAB.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding	p.R185W(1)		endometrium(2)|kidney(2)|large_intestine(7)|lung(5)|stomach(1)|urinary_tract(1)	18						ACATAATACCGTATTCGATCA	0.448000													56	84					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350261	100350261	+	RNA	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100350261A>G	ENST00000542585.1	+	0	2681				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AAAACTCACCATCCCCATGGA	0.488000													6	95					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46658026	46658026	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:46658026G>T	ENST00000253255.5	-	1	1193	c.1194C>A	c.(1192-1194)gtC>gtA	p.V398V		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	398	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CGGGGTGACAGACTTCCTTGC	0.532000													28	62					4.87955e-14	5.31433e-14	1	1	0
E4F1	1877	broad.mit.edu	37	16	2285489	2285489	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2285489G>T	ENST00000301727.4	+	14	2319	c.2271G>T	c.(2269-2271)gaG>gaT	p.E757D	E4F1_ENST00000564139.1_3'UTR|E4F1_ENST00000565090.1_Missense_Mutation_p.E580D	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	757					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						TGTCATCAGAGGACATCGAGA	0.647000													3	7					0.004672	0.00472505	1	1	0
MAP4K4	9448	broad.mit.edu	37	2	102505311	102505311	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:102505311C>T	ENST00000413150.2	+	28	3350	c.3295C>T	c.(3295-3297)Cga>Tga	p.R1099*	MAP4K4_ENST00000347699.4_Nonsense_Mutation_p.R1184*|MAP4K4_ENST00000324219.4_Nonsense_Mutation_p.R1265*|MAP4K4_ENST00000350198.4_Nonsense_Mutation_p.R1111*|MAP4K4_ENST00000425019.1_Nonsense_Mutation_p.R1217*|MAP4K4_ENST00000302217.5_Nonsense_Mutation_p.R987*|MAP4K4_ENST00000350878.4_Nonsense_Mutation_p.R1224*|MAP4K4_ENST00000456652.1_Nonsense_Mutation_p.R983*	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	1184	CNH.|Mediates interaction with RAP2A.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CATAGAGATCCGATCTGTGGA	0.438000													4	18					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14031458	14031458	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:14031458C>T	ENST00000318003.7	+	13	1686	c.1445C>T	c.(1444-1446)cCc>cTc	p.P482L	CC2D1A_ENST00000589606.1_Missense_Mutation_p.P482L	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	482					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GCCAAAGCGCCCCCCAAAGCC	0.652000													4	4					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69726202	69726202	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:69726202A>G	ENST00000349945.1	+	14	3744	c.2192A>G	c.(2191-2193)cAg>cGg	p.Q731R	NFAT5_ENST00000567239.1_Missense_Mutation_p.Q824R|NFAT5_ENST00000393742.2_Missense_Mutation_p.Q731R|NFAT5_ENST00000432919.1_Missense_Mutation_p.Q825R|NFAT5_ENST00000354436.2_Missense_Mutation_p.Q807R|NFAT5_ENST00000566899.1_Missense_Mutation_p.Q731R	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	807					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GCACAGCAGCAGTTATCTTCA	0.433000													13	58					0	0	1	0	0
SETD7	80854	broad.mit.edu	37	4	140439119	140439119	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:140439119G>T	ENST00000274031.3	-	7	1476	c.840C>A	c.(838-840)ccC>ccA	p.P280P	SETD7_ENST00000506866.2_Silent_p.P280P	NM_030648.2	NP_085151.1	Q8WTS6	SETD7_HUMAN	SET domain containing (lysine methyltransferase) 7	280	SET.				peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	8	all_hematologic(180;0.156)					CGTGGTTATAGGGCTCAGGCA	0.493000													12	60					0.00136819	0.00138908	1	1	0
MBD5	0	broad.mit.edu	37	2	149247602	149247602	+	Silent	SNP	C	C	A	rs144957555	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:149247602C>A	ENST00000407073.1	+	12	4699	c.3702C>A	c.(3700-3702)gtC>gtA	p.V1234V	MBD5_ENST00000404807.1_Silent_p.V1467V	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1234						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CCAACAATGTCTCTACACTGC	0.453000													21	19					9.95505e-16	1.0907e-15	1	1	0
ANAPC1	64682	broad.mit.edu	37	2	112630929	112630929	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:112630929G>A	ENST00000341068.3	-	5	1256	c.484C>T	c.(484-486)Cat>Tat	p.H162Y	ANAPC1_ENST00000489177.1_5'UTR	NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	162					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						TCTATGCTATGCATGTTAATA	0.333000													22	47					0	0	1	0	0
SPINK14	408187	broad.mit.edu	37	5	147553880	147553880	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:147553880C>T	ENST00000356972.1	+	3	195	c.195C>T	c.(193-195)tgC>tgT	p.C65C	SPINK14_ENST00000562793.1_Intron	NM_001001325.1	NP_001001325.1	Q6IE38	ISK14_HUMAN	serine peptidase inhibitor, Kazal type 14 (putative)	65	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|large_intestine(1)|lung(1)	3						AACCCATCTGCGGCACCAATT	0.423000													6	58					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56393793	56393793	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56393793G>A	ENST00000355701.3	-	15	2851	c.1981C>T	c.(1981-1983)Cgt>Tgt	p.R661C	BZRAP1_ENST00000268893.6_Missense_Mutation_p.R601C|BZRAP1_ENST00000343736.4_Missense_Mutation_p.R661C	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	661	SH3 1.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CACCTATAACGTGCTAGGAAG	0.647000													23	36					0	0	1	0	0
CD86	942	broad.mit.edu	37	3	121822507	121822507	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:121822507C>T	ENST00000330540.2	+	3	329	c.213C>T	c.(211-213)ggC>ggT	p.G71G	CD86_ENST00000393627.2_Silent_p.G65G|CD86_ENST00000264468.5_Intron|CD86_ENST00000469710.1_5'UTR|CD86_ENST00000493101.1_Intron	NM_175862.4	NP_787058.4	P42081	CD86_HUMAN	CD86 molecule	71	Ig-like V-type.				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	TATACTTAGGCAAAGAGAAAT	0.428000													44	80					0	0	1	0	0
NAPG	8774	broad.mit.edu	37	18	10546334	10546334	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:10546334C>T	ENST00000322897.6	+	9	587	c.518C>T	c.(517-519)gCg>gTg	p.A173V	NAPG_ENST00000542979.1_Missense_Mutation_p.A91V	NM_003826.2	NP_003817.1	Q99747	SNAG_HUMAN	N-ethylmaleimide-sensitive factor attachment protein, gamma	173					cellular membrane fusion|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein complex assembly|protein stabilization	membrane|membrane fraction|mitochondrion	protein binding			large_intestine(2)|lung(2)	4						TTTGATGAGGCGGCACTCTCT	0.318000													3	7					0	0	1	0	0
PTPRB	0	broad.mit.edu	37	12	71003069	71003069	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:71003069C>A	ENST00000334414.6	-	4	803	c.759G>T	c.(757-759)aaG>aaT	p.K253N	PTPRB_ENST00000551525.1_Missense_Mutation_p.K252N|PTPRB_ENST00000550358.1_Missense_Mutation_p.K253N|PTPRB_ENST00000550857.1_Missense_Mutation_p.K35N|PTPRB_ENST00000451516.2_Missense_Mutation_p.K35N|PTPRB_ENST00000538708.1_Missense_Mutation_p.K35N|PTPRB_ENST00000261266.5_Missense_Mutation_p.K35N|PTPRB_ENST00000538174.2_5'UTR	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	35	Fibronectin type-III 3.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGCTGGAGGCCTTGGACTCCG	0.537000													15	16					1.49906e-05	1.54943e-05	1	1	0
DHX38	9785	broad.mit.edu	37	16	72142736	72142736	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:72142736C>A	ENST00000268482.3	+	24	3802	c.3293C>A	c.(3292-3294)cCc>cAc	p.P1098H	DHX38_ENST00000536867.1_Missense_Mutation_p.P410H	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	1098					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				ACAGGGATGCCCTGCCACTTG	0.547000													16	20					1.67942e-08	1.77343e-08	1	1	0
ARMCX2	9823	broad.mit.edu	37	X	100911832	100911832	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:100911832G>A	ENST00000328766.5	-	5	1196	c.743C>T	c.(742-744)gCg>gTg	p.A248V	ARMCX2_ENST00000330154.2_Missense_Mutation_p.A248V|ARMCX2_ENST00000356824.4_Missense_Mutation_p.A248V	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	248	Ala-rich.					integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						AGGAACCACCGCTGTTCTAGG	0.607000													30	8					0	0	1	0	0
SLC12A9	56996	broad.mit.edu	37	7	100463550	100463550	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100463550G>A	ENST00000354161.3	+	14	2193	c.2068G>A	c.(2068-2070)Gcc>Acc	p.A690T		NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	690						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGTGGCCGACGCCCTCAAGAT	0.701000													28	26					0	0	1	0	0
ADAM15	8751	broad.mit.edu	37	1	155026631	155026631	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155026631C>A	ENST00000356955.2	+	5	449	c.348C>A	c.(346-348)aaC>aaA	p.N116K	ADAM15_ENST00000368410.2_Intron|ADAM15_ENST00000271836.6_Missense_Mutation_p.N116K|ADAM15_ENST00000368413.1_Intron|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000531455.1_Missense_Mutation_p.N126K|ADAM15_ENST00000368412.3_Missense_Mutation_p.N116K|ADAM15_ENST00000360674.4_Missense_Mutation_p.N116K|ADAM15_ENST00000355956.2_Missense_Mutation_p.N116K|ADAM15_ENST00000359280.4_Missense_Mutation_p.N116K|ADAM15_ENST00000447332.3_Missense_Mutation_p.N100K|ADAM15_ENST00000449910.2_Missense_Mutation_p.N116K	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	116					angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TGCAGGAGAACTGCTGCTACC	0.532000													21	43					3.5997e-14	3.92294e-14	1	1	0
OR51G2	81282	broad.mit.edu	37	11	4935968	4935968	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:4935968G>A	ENST00000322013.3	-	1	954	c.926C>T	c.(925-927)aCg>aTg	p.T309M	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAAGGCATGCGTCACTCGATC	0.438000													5	12					0	0	1	0	0
GBP5	115362	broad.mit.edu	37	1	89730602	89730602	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:89730602C>T	ENST00000343435.5	-	8	1452	c.916G>A	c.(916-918)Gat>Aat	p.D306N	GBP5_ENST00000370459.3_Missense_Mutation_p.D306N|RP4-620F22.2_ENST00000437128.1_RNA|GBP5_ENST00000481145.1_5'UTR	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	306						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		CAAGGCAGATCCCCACTGCTG	0.463000													18	42					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24524777	24524777	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24524777C>T	ENST00000342740.5	+	9	785	c.631C>T	c.(631-633)Ctg>Ttg	p.L211L	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	211										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GGTAGCAGCCCTGGCCTACAA	0.572000													32	32					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47685270	47685270	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:47685270G>A	ENST00000393331.3	-	9	1150	c.680C>T	c.(679-681)gCc>gTc	p.A227V	SPOP_ENST00000347630.2_Missense_Mutation_p.A227V|SPOP_ENST00000504102.1_Missense_Mutation_p.A227V|SPOP_ENST00000503676.1_Missense_Mutation_p.A227V|SPOP_ENST00000393328.2_Missense_Mutation_p.A227V	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	227	BTB.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						TTCAAACATGGCACTAAAAAC	0.408000										Prostate(2;0.17)			4	131					0	0	1	0	0
DEAF1	10522	broad.mit.edu	37	11	686974	686974	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:686974G>A	ENST00000382409.3	-	5	1172	c.688C>T	c.(688-690)Cag>Tag	p.Q230*	DEAF1_ENST00000338675.6_Intron	NM_021008.2	NP_066288.2	O75398	DEAF1_HUMAN	DEAF1 transcription factor	230	SAND.				embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		TTCTCCCCCTGCTTGATGCAC	0.612000													12	14					0	0	1	0	0
LASP1	3927	broad.mit.edu	37	17	37074902	37074902	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:37074902C>T	ENST00000318008.6	+	7	988	c.657C>T	c.(655-657)gaC>gaT	p.D219D	LASP1_ENST00000435347.3_Silent_p.D219D|LASP1_ENST00000433206.2_Silent_p.D163D	NM_006148.2	NP_006139.1	Q14847	LASP1_HUMAN	LIM and SH3 protein 1	219	SH3.					cortical actin cytoskeleton	ion transmembrane transporter activity|SH3/SH2 adaptor activity|zinc ion binding			breast(1)|large_intestine(2)|lung(4)|urinary_tract(2)	9						CCGACGAGGACGAGGTCTCCT	0.662000			T	MLL	AML								16	70					0	0	1	0	0
RP1-274L7.1	0	broad.mit.edu	37	X	129629515	129629515	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:129629515C>T	ENST00000458525.1	-	0	1015				FAM45B_ENST00000592932.1_RNA																							AGTTATATTGCAGTTCTCACA	0.438000													33	35					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71788950	71788950	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:71788950G>A	ENST00000258104.3	+	23	2508	c.2231G>A	c.(2230-2232)cGc>cAc	p.R744H	DYSF_ENST00000429174.2_Missense_Mutation_p.R744H|DYSF_ENST00000410020.3_Missense_Mutation_p.R762H|DYSF_ENST00000409762.1_Missense_Mutation_p.R761H|DYSF_ENST00000409744.1_Missense_Mutation_p.R731H|DYSF_ENST00000409651.1_Missense_Mutation_p.R776H|DYSF_ENST00000409366.1_Missense_Mutation_p.R745H|DYSF_ENST00000394120.2_Missense_Mutation_p.R745H|DYSF_ENST00000413539.2_Missense_Mutation_p.R775H|DYSF_ENST00000409582.3_Missense_Mutation_p.R761H|DYSF_ENST00000410041.1_Missense_Mutation_p.R762H	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	744						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TACCAGCTGCGCACCCATCAC	0.632000													14	20					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47251793	47251793	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:47251793C>A	ENST00000296861.2	-	3	1517	c.1124G>T	c.(1123-1125)aGg>aTg	p.R375M		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	375					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			TTTCAGAGTCCTCGAGCTTTT	0.512000													4	80					0.014758	0.0148771	1	1	0
MKX	283078	broad.mit.edu	37	10	27964290	27964290	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:27964290G>A	ENST00000375790.5	-	7	1359	c.927C>T	c.(925-927)aaC>aaT	p.N309N	MKX_ENST00000419761.1_Silent_p.N309N			Q8IYA7	MKX_HUMAN	mohawk homeobox	309					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						CCATAGCTGCGTTGATCTCCT	0.453000													46	75					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145106948	145106948	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145106948G>A	ENST00000426825.1	-	25	3574	c.3493C>T	c.(3493-3495)Cgg>Tgg	p.R1165W	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1165							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GCCCCCCGCCGCAGCTCGAAG	0.741000													10	20					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179401677	179401677	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179401677T>C	ENST00000589042.1	-	356	100383	c.100159A>G	c.(100159-100161)Aag>Gag	p.K33387E	TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.K24514E|TTN_ENST00000591111.1_Missense_Mutation_p.K31746E|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.K24322E|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.K30819E|TTN_ENST00000359218.5_Missense_Mutation_p.K24447E|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000588804.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31746	Ig-like 146.		T -> M.				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATGGACTCTTAATGATCACA	0.383000													8	8					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8757907	8757907	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:8757907C>T	ENST00000229335.6	-	3	434	c.331G>A	c.(331-333)Gcg>Acg	p.A111T	AICDA_ENST00000537228.1_Missense_Mutation_p.A111T	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	111					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding	p.A111T(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					TAGAGGCGCGCGGTGAAGATC	0.637000													12	17					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468348	56468348	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:56468348C>T	ENST00000312153.1	+	1	485	c.485C>T	c.(484-486)aCg>aTg	p.T162M		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						ACCAAGAAAACGTTTTCCTTT	0.448000													17	67					0	0	1	0	0
GALNT2	2590	broad.mit.edu	37	1	230372099	230372099	+	Splice_Site	SNP	C	C	T	rs143842900	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:230372099C>T	ENST00000366672.4	+	5	546	c.473_splice	c.e5-1	p.S158_splice	GALNT2_ENST00000543760.1_Splice_Site_p.S120_splice|GALNT2_ENST00000541865.1_Splice_Site_p.S68_splice	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	158	Catalytic subdomain A.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				CTTTTCTTAGCGTGCTTAAGA	0.398000													13	53					0	0	1	0	0
INCENP	3619	broad.mit.edu	37	11	61908487	61908487	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61908487C>T	ENST00000394818.3	+	10	1766	c.1564C>T	c.(1564-1566)Cgc>Tgc	p.R522C	INCENP_ENST00000278849.4_Missense_Mutation_p.R522C	NM_001040694.1	NP_001035784.1	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	522					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						CTTTATTAAGCGCAACACTCC	0.622000													6	14					0	0	1	0	0
ARL17A	51326	broad.mit.edu	37	17	44594546	44594546	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:44594546C>T	ENST00000445552.2	-	4	399	c.313G>A	c.(313-315)Ggc>Agc	p.G105S	LRRC37A2_ENST00000576629.1_Intron|ARL17A_ENST00000329240.4_Missense_Mutation_p.G105S|ARL17A_ENST00000337845.7_Silent_p.P193P|LRRC37A2_ENST00000333412.3_Intron	NM_016632.2	NP_057716.2	Q8IVW1	ARL17_HUMAN	ADP-ribosylation factor-like 17A	0					protein transport|vesicle-mediated transport	Golgi apparatus	GTP binding			lung(1)	1						TCATTTGTGCCGGTGACCCCG	0.403000													64	118					0	0	1	0	0
GTF2E1	2960	broad.mit.edu	37	3	120469788	120469788	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:120469788C>A	ENST00000283875.5	+	2	482	c.389C>A	c.(388-390)cCt>cAt	p.P130H		NM_005513.2	NP_005504.2	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1, alpha 56kDa	130					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)	22				GBM - Glioblastoma multiforme(114;0.159)		TTCAAATGTCCTGTCTGTAGT	0.393000													16	37					3.41278e-10	3.64137e-10	1	1	0
C2orf53	339779	broad.mit.edu	37	2	27360640	27360640	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27360640G>A	ENST00000335524.3	-	3	1083	c.558C>T	c.(556-558)tcC>tcT	p.S186S		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	186										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGGGACCCGGACCCAGTGT	0.637000													22	22					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156247016	156247016	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156247016C>A	ENST00000361813.5	-	4	458	c.314G>T	c.(313-315)aGc>aTc	p.S105I	SMG5_ENST00000368267.4_Missense_Mutation_p.S105I	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	105					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					TTCCAAAGTGCTCCGGCTGTG	0.522000													6	10					0.00116845	0.0011864	1	1	0
COX7A1	1346	broad.mit.edu	37	19	36642611	36642611	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36642611C>T	ENST00000292907.3	-	2	523	c.62G>A	c.(61-63)cGc>cAc	p.R21H	COX7A1_ENST00000437291.2_5'UTR	NM_001864.2	NP_001855.1	P24310	CX7A1_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)	21					generation of precursor metabolites and energy	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity			endometrium(2)|large_intestine(1)	3	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GTTCTGAAAGCGGTTCCGGGC	0.706000													3	6					0	0	1	0	0
DHRS4L2	317749	broad.mit.edu	37	14	24459436	24459436	+	Silent	SNP	C	C	T	rs11556286		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24459436C>T	ENST00000335125.6	+	2	300	c.174C>T	c.(172-174)caC>caT	p.H58H	DHRS4L2_ENST00000558753.1_Silent_p.H58H|DHRS4L2_ENST00000545240.1_Silent_p.H58H|DHRS4L2_ENST00000543805.1_5'UTR|DHRS4L2_ENST00000537912.1_Silent_p.H58H|DHRS4L2_ENST00000534993.1_5'UTR|DHRS4L2_ENST00000382755.4_Silent_p.H56H|DHRS4L2_ENST00000397071.1_Silent_p.H58H	NM_198083.3	NP_932349.2	D5KJA1	D5KJA1_HUMAN	dehydrogenase/reductase (SDR family) member 4 like 2	30							binding|oxidoreductase activity			breast(1)|endometrium(2)|kidney(1)|lung(2)|ovary(1)|skin(2)|stomach(1)	10				GBM - Glioblastoma multiforme(265;0.00962)		ACAGGGCCCACGTGGTCGTCA	0.652000													24	43					0	0	1	0	0
ANAPC7	51434	broad.mit.edu	37	12	110815420	110815420	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:110815420G>A	ENST00000455511.3	-	9	1237	c.1237C>T	c.(1237-1239)Ctt>Ttt	p.L413F	ANAPC7_ENST00000450008.2_Missense_Mutation_p.L413F|ANAPC7_ENST00000481473.1_5'UTR	NM_016238.2	NP_057322.2	Q9UJX3	APC7_HUMAN	anaphase promoting complex subunit 7	413					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)	19						CATTCGATAAGACCTGAAAAA	0.413000													26	30					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109271293	109271293	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109271293C>T	ENST00000370017.3	+	8	1686	c.1409C>T	c.(1408-1410)gCa>gTa	p.A470V	FNDC7_ENST00000271311.2_Missense_Mutation_p.A471V	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	471	Fibronectin type-III 6.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		TCAAGGGATGCATTCTCCATG	0.413000													15	45					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143092710	143092710	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:143092710G>A	ENST00000367603.2	-	5	3908	c.3166C>T	c.(3166-3168)Ctg>Ttg	p.L1056L	HIVEP2_ENST00000367604.1_Silent_p.L1056L|HIVEP2_ENST00000012134.2_Silent_p.L1056L	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1056					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GCATGGGACAGATTCCCATAA	0.552000													19	14					0	0	1	0	0
PTPRA	0	broad.mit.edu	37	20	2967425	2967425	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:2967425A>G	ENST00000216877.6	+	6	830	c.430A>G	c.(430-432)Att>Gtt	p.I144V	PTPRA_ENST00000399903.2_Missense_Mutation_p.I153V|PTPRA_ENST00000425918.2_Missense_Mutation_p.I164V|PTPRA_ENST00000380393.3_Missense_Mutation_p.I153V|PTPRA_ENST00000356147.3_Missense_Mutation_p.I144V|PTPRA_ENST00000358719.4_5'UTR|PTPRA_ENST00000318266.5_Missense_Mutation_p.I144V	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	144					axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GACACCAATTATTGCGGTGAT	0.433000													31	58					0	0	1	0	0
IYD	389434	broad.mit.edu	37	6	150719366	150719366	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:150719366C>T	ENST00000344419.3	+	5	1003	c.863C>T	c.(862-864)aCa>aTa	p.T288I	IYD_ENST00000229447.5_3'UTR	NM_203395.2	NP_981932.1	Q6PHW0	IYD1_HUMAN	iodotyrosine deiodinase	288					cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	15		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		ATCATGGTGACAGTGTAGGCA	0.622000													11	29					0	0	1	0	0
TXLNA	200081	broad.mit.edu	37	1	32653640	32653640	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32653640G>A	ENST00000373609.1	+	4	964	c.683G>A	c.(682-684)cGc>cAc	p.R228H	TXLNA_ENST00000373610.3_Missense_Mutation_p.R228H			P40222	TXLNA_HUMAN	taxilin alpha	228				R -> C (in Ref. 5; AAH80578).	cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GACCACCTGCGCGGTGAGCAC	0.617000													5	6					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14578311	14578311	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:14578311C>T	ENST00000544627.1	+	2	1806	c.1486C>T	c.(1486-1488)Cca>Tca	p.P496S	ATF7IP_ENST00000543189.1_Missense_Mutation_p.P488S|ATF7IP_ENST00000536444.1_Missense_Mutation_p.P488S|ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000540793.1_Missense_Mutation_p.P488S|ATF7IP_ENST00000261168.4_Missense_Mutation_p.P488S			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	488	Glu-rich.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TGAGAGTTTGCCAAAAGAAGC	0.393000													22	41					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3807828	3807828	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3807828T>C	ENST00000262367.5	-	18	4400	c.3591A>G	c.(3589-3591)ggA>ggG	p.G1197G	CREBBP_ENST00000382070.3_Silent_p.G1159G	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1197					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CACAGCAATATCCAAGGGACT	0.453000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						15	22					0	0	1	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411907	39411907	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39411907C>T	ENST00000394008.1	+	1	272	c.270C>T	c.(268-270)tgC>tgT	p.C90C		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	90						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GGTCCAGCTGCTGTGGCCAAA	0.632000													33	31					0	0	1	0	0
OR4C12	283093	broad.mit.edu	37	11	50003697	50003697	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:50003697G>A	ENST00000335238.4	-	1	374	c.341C>T	c.(340-342)aCa>aTa	p.T114I		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						GGCCATCACTGTCAGCAGGAT	0.483000													35	63					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32169087	32169087	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32169087C>T	ENST00000375023.3	-	22	4084	c.3946G>A	c.(3946-3948)Gcc>Acc	p.A1316T		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1316					cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						AGCACCCGGGCCAGGGCAAAC	0.647000													19	15					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157527546	157527546	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:157527546C>T	ENST00000346085.5	+	20	5272	c.5271C>T	c.(5269-5271)agC>agT	p.S1757S	ARID1B_ENST00000367148.1_Silent_p.S1797S|ARID1B_ENST00000350026.5_Silent_p.S1744S|ARID1B_ENST00000275248.4_Silent_p.S1739S	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1744					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		AGACAGAAAGCGATGAAAAGA	0.527000													33	60					0	0	1	0	0
RHOJ	57381	broad.mit.edu	37	14	63747840	63747840	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:63747840T>C	ENST00000316754.3	+	3	851	c.389T>C	c.(388-390)cTc>cCc	p.L130P	RHOJ_ENST00000555125.1_Missense_Mutation_p.L130P	NM_020663.4	NP_065714.1	Q9H4E5	RHOJ_HUMAN	ras homolog family member J	130					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|upper_aerodigestive_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		CCTTATGTCCTCATAGGGACC	0.527000													3	15					0	0	1	0	0
WEE1	7465	broad.mit.edu	37	11	9608137	9608137	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:9608137C>T	ENST00000299613.6	+	9	1725	c.970C>T	c.(970-972)Ctt>Ttt	p.L324F	WEE1_ENST00000450114.2_Missense_Mutation_p.L538F	NM_001143976.1	NP_001137448.1	P30291	WEE1_HUMAN	WEE1 G2 checkpoint kinase	538	Protein kinase.				blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	23				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		ACCACAAGTGCTTTCCCAAGA	0.398000													35	53					0	0	1	0	0
ZNF429	353088	broad.mit.edu	37	19	21720843	21720843	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:21720843G>A	ENST00000358491.4	+	4	2196	c.1988G>A	c.(1987-1989)cGg>cAg	p.R663Q	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	663					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						agaggtgggcggatcacgagg	0.453000													13	37					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85863022	85863022	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:85863022G>A	ENST00000304195.3	-	14	1811	c.1605C>T	c.(1603-1605)ggC>ggT	p.G535G	FRMD3_ENST00000465485.1_5'UTR|FRMD3_ENST00000328788.1_Silent_p.G192G|FRMD3_ENST00000376438.1_Silent_p.G535G|FRMD3_ENST00000376434.1_Silent_p.G341G	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	535						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						GCAGTCCCAGGCCCACCACAA	0.527000													11	14					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53012272	53012272	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53012272C>T	ENST00000305748.3	-	1	71	c.37G>A	c.(37-39)Gcc>Acc	p.A13T		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	13	Gly-rich.|Head.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCCCCCTTGGCAGCAGCTCCC	0.617000													23	36					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70909410	70909410	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:70909410C>T	ENST00000322773.4	+	49	3295	c.3193C>T	c.(3193-3195)Cct>Tct	p.P1065S	COL19A1_ENST00000393344.1_Missense_Mutation_p.P687S	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	1065	Triple-helical region 6 (COL6).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GGATGGGTTGCCTGGGCCACC	0.493000													16	39					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233407646	233407646	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:233407646C>T	ENST00000389494.3	+	7	680	c.659C>T	c.(658-660)gCg>gTg	p.A220V	CHRNG_ENST00000389492.3_Missense_Mutation_p.A168V	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	220					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CTGGACCCAGCGGCGCCAGCC	0.632000													14	16					0	0	1	0	0
CAPN1	823	broad.mit.edu	37	11	64974115	64974115	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64974115G>A	ENST00000527323.1	+	12	1775	c.1535G>A	c.(1534-1536)cGc>cAc	p.R512H	CAPN1_ENST00000279247.6_Missense_Mutation_p.R512H|CAPN1_ENST00000524773.1_Missense_Mutation_p.R512H|CAPN1_ENST00000533820.1_Missense_Mutation_p.R512H|CAPN1_ENST00000533129.1_Missense_Mutation_p.R512H			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	512	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		TTCGTGCTGCGCTTCTTCTCA	0.647000													14	25					0	0	1	0	0
SMARCD1	6602	broad.mit.edu	37	12	50483696	50483696	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:50483696C>T	ENST00000394963.4	+	7	1199	c.801C>T	c.(799-801)acC>acT	p.T267T	SMARCD1_ENST00000381513.4_Silent_p.T267T|SMARCD1_ENST00000548573.1_Silent_p.T65T	NM_003076.4	NP_003067.3	Q96GM5	SMRD1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	267	Interaction with SMARCC1 and SMARCC2.|Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin; required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo.				chromatin-mediated maintenance of transcription|nervous system development|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	protein complex scaffold|transcription coactivator activity			NS(1)|breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	18						CCCAGGAGACCGATGGCTTTC	0.577000													8	19					0	0	1	0	0
MXD3	83463	broad.mit.edu	37	5	176734595	176734595	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176734595C>T	ENST00000439742.2	-	6	1093	c.615G>A	c.(613-615)tgG>tgA	p.W205*	MXD3_ENST00000423571.2_Missense_Mutation_p.G231D|MXD3_ENST00000427908.2_Intron|MXD3_ENST00000513063.1_Nonsense_Mutation_p.W205*	NM_031300.3	NP_112590.1	Q9BW11	MAD3_HUMAN	MAX dimerization protein 3	205					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding					all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AACATCATAGCCAGGCGCCGC	0.687000													6	15					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1573865	1573865	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1573865G>A	ENST00000426508.2	-	25	3597	c.3234C>T	c.(3232-3234)ggC>ggT	p.G1078G	IFT140_ENST00000361339.5_Silent_p.G272G	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	1078										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				CCATCTGCACGCCCTTCTCCT	0.667000													7	20					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42761257	42761257	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:42761257C>T	ENST00000379274.2	+	14	1632	c.1203C>T	c.(1201-1203)gcC>gcT	p.A401A	DGKH_ENST00000540693.1_Silent_p.A537A|DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000337343.4_Silent_p.A537A|DGKH_ENST00000538674.1_Silent_p.A292A|DGKH_ENST00000536612.1_Silent_p.A401A|DGKH_ENST00000261491.4_Silent_p.A537A			Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta	537	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		TGGAAAATGCCGTTGTAGCTG	0.413000													25	43					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209167059	209167059	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:209167059G>A	ENST00000264380.4	+	10	1460	c.1302G>A	c.(1300-1302)gcG>gcA	p.A434A	PIKFYVE_ENST00000392202.3_Silent_p.A337A|PIKFYVE_ENST00000308862.6_Silent_p.A348A|PIKFYVE_ENST00000407449.1_Silent_p.A434A	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	434	DEP.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						ATGAGTATGCGCTGTATAGAC	0.408000													4	34					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240072217	240072217	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:240072217C>T	ENST00000255380.4	+	5	2245	c.1466C>T	c.(1465-1467)gCg>gTg	p.A489V		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	489					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GAGAAGAAAGCGGCCCAGACC	0.512000													29	44					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68591960	68591960	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:68591960C>T	ENST00000570495.1	+	3	385	c.93C>T	c.(91-93)gtC>gtT	p.V31V	ZFP90_ENST00000564323.1_Silent_p.V31V|ZFP90_ENST00000563169.2_Silent_p.V31V|ZFP90_ENST00000570884.1_3'UTR|ZFP90_ENST00000398253.2_Silent_p.V31V			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	31	KRAB.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.V31V(1)		breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		GGTACCATGTCGACCCTGCTC	0.478000													42	64					0	0	1	0	0
MAP10	54627	broad.mit.edu	37	1	232940773	232940773	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:232940773G>A	ENST00000418460.1	+	1	131	c.4G>A	c.(4-6)Gcc>Acc	p.A2T		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		CACAGAGATGGCCCACTGTGG	0.483000													4	75					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20648287	20648287	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:20648287G>A	ENST00000525748.1	+	8	1567	c.1294G>A	c.(1294-1296)Gta>Ata	p.V432I		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	432					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	CCCGTATGTCGTACTCGTGAT	0.582000													22	28					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153696474	153696474	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153696474C>T	ENST00000369682.3	+	22	4045	c.3870C>T	c.(3868-3870)gaC>gaT	p.D1290D		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1290					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCACATGGACGAGGTGCAGA	0.622000													21	3					0	0	1	0	0
COQ5	84274	broad.mit.edu	37	12	120960094	120960094	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:120960094C>T	ENST00000288532.6	-	2	315	c.275G>A	c.(274-276)cGt>cAt	p.R92H	COQ5_ENST00000445328.2_Missense_Mutation_p.R92H	NM_032314.3	NP_115690.3	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	92					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity	p.R92H(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(3)	20	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTTCCAAACACGATGGATACC	0.458000													19	37					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47629002	47629002	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:47629002G>A	ENST00000546455.1	+	4	887	c.156G>A	c.(154-156)ggG>ggA	p.G52G	PCED1B_ENST00000432328.1_Silent_p.G52G					PC-esterase domain containing 1B																		GAGCAAGGGGGGAGCTGAACT	0.612000													12	17					0	0	1	0	0
TMEM55A	55529	broad.mit.edu	37	8	92033484	92033484	+	Splice_Site	SNP	C	C	T	rs145247675	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:92033484C>T	ENST00000285419.3	-	2	569	c.255_splice	c.e2+1	p.T85_splice		NM_018710.2	NP_061180.1	Q8N4L2	TM55A_HUMAN	transmembrane protein 55A	85						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	13			BRCA - Breast invasive adenocarcinoma(11;0.033)			CTCCACTTACCGTAGCTTCAT	0.348000													25	65					0	0	1	0	0
ELP3	55140	broad.mit.edu	37	8	28017893	28017893	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:28017893G>A	ENST00000256398.8	+	13	1782	c.1405G>A	c.(1405-1407)Gtc>Atc	p.V469I	ELP3_ENST00000524103.1_Missense_Mutation_p.V397I|ELP3_ENST00000521015.1_Missense_Mutation_p.V455I|ELP3_ENST00000380353.4_Missense_Mutation_p.V377I|ELP3_ENST00000537665.1_Missense_Mutation_p.V350I|ELP3_ENST00000542181.1_Missense_Mutation_p.V340I	NM_018091.5	NP_060561.3	Q9H9T3	ELP3_HUMAN	elongator acetyltransferase complex subunit 3	469	N-acetyltransferase.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding			kidney(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		GGGTGGAGGTGTCTCCATAGT	0.458000													15	23					0	0	1	0	0
TTLL4	9654	broad.mit.edu	37	2	219609893	219609893	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219609893C>A	ENST00000392102.1	+	6	2063	c.1723C>A	c.(1723-1725)Ctc>Atc	p.L575I	TTLL4_ENST00000442769.1_Missense_Mutation_p.L575I|TTLL4_ENST00000258398.4_Missense_Mutation_p.L575I|TTLL4_ENST00000457313.1_Missense_Mutation_p.L410I	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	575					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		CCGACCAGCCCTCATCTACAG	0.473000													42	67					2.24893e-16	2.47033e-16	1	1	0
KLRC1	3821	broad.mit.edu	37	12	10603748	10603748	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:10603748T>C	ENST00000544822.1	-	3	395	c.8A>G	c.(7-9)aAc>aGc	p.N3S	KLRC1_ENST00000408006.3_Missense_Mutation_p.N3S|KLRC1_ENST00000347831.5_Missense_Mutation_p.N3S|KLRC1_ENST00000536188.1_Missense_Mutation_p.N3S|KLRC1_ENST00000359151.3_Missense_Mutation_p.N3S	NM_213658.2	NP_998823.1	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C, member 1	3					cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16						TACTCCTTGGTTATCCATCTC	0.393000													11	19					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42855367	42855367	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42855367G>T	ENST00000334370.4	+	15	3170		c.e15-1		MEGF8_ENST00000251268.6_Splice_Site	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8							integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				CTGACCCCCAGGACCCCTTCT	0.667000													3	2					0.00024832	0.000253518	1	1	0
ELANE	1991	broad.mit.edu	37	19	852991	852991	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:852991G>A	ENST00000590230.1	+	3	324	c.183G>A	c.(181-183)gcG>gcA	p.A61A	ELANE_ENST00000263621.1_Silent_p.A61A			P08246	ELNE_HUMAN	elastase, neutrophil expressed	61	Peptidase S1.				cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(1)|lung(4)|pancreas(1)	13					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CCCTGATTGCGCCCAACTTCG	0.716000													3	6					0	0	1	0	0
YES1	7525	broad.mit.edu	37	18	756827	756827	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:756827T>C	ENST00000577961.1	-	2	86	c.16A>G	c.(16-18)Atg>Gtg	p.M6V	YES1_ENST00000577611.1_5'UTR|YES1_ENST00000314574.4_Start_Codon_SNP_p.M1V|YES1_ENST00000584307.1_Start_Codon_SNP_p.M1V			P07947	YES_HUMAN	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	1					blood coagulation|leukocyte migration|regulation of vascular permeability|T cell costimulation	cytosol|plasma membrane	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(1)	17					Dasatinib(DB01254)	ATGCAGCCCATTATCAAATCT	0.343000													12	24					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7067910	7067910	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7067910G>A	ENST00000299481.4	+	5	2316	c.1970G>A	c.(1969-1971)cGc>cAc	p.R657H		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	657					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding	p.R657H(2)		breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GATGGTGATCGCATTACTCAC	0.373000													53	79					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8175995	8175995	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8175995C>T	ENST00000600128.1	-	33	4571	c.4157G>A	c.(4156-4158)cGc>cAc	p.R1386H	FBN3_ENST00000270509.2_Missense_Mutation_p.R1386H|FBN3_ENST00000601739.1_Missense_Mutation_p.R1386H			Q75N90	FBN3_HUMAN	fibrillin 3	1386	EGF-like 21; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ACATTCACAGCGGTACCCGCC	0.652000													9	12					0	0	1	0	0
CACTIN	58509	broad.mit.edu	37	19	3623889	3623889	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3623889G>A	ENST00000429344.2	-	2	491	c.439C>T	c.(439-441)Cgg>Tgg	p.R147W	CACTIN_ENST00000248420.5_Missense_Mutation_p.R147W|CACTIN_ENST00000221899.3_Missense_Mutation_p.R79W	NM_001080543.1	NP_001074012.1			cactin, spliceosome C complex subunit																		CGCTCCTCCCGCAGCCGCAGC	0.711000													11	15					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137681047	137681047	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:137681047G>A	ENST00000371817.3	+	32	3107	c.2693G>A	c.(2692-2694)gGc>gAc	p.G898D		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	898	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGAGAGAAGGGCGGCAGGGTA	0.572000													7	10					0	0	1	0	0
ARMC9	80210	broad.mit.edu	37	2	232209767	232209767	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:232209767C>T	ENST00000349938.4	+	21	2153	c.1959C>T	c.(1957-1959)ccC>ccT	p.P653P	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.3	NP_001258395.1|NP_079415.3	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	653							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		TGCAAAGGCCCGTCACCCCCG	0.537000													20	39					0	0	1	0	0
MAU2	23383	broad.mit.edu	37	19	19451659	19451659	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19451659C>T	ENST00000392313.5	+	6	602	c.556C>T	c.(556-558)Ctg>Ttg	p.L186L	MAU2_ENST00000585823.2_3'UTR|MAU2_ENST00000262815.8_Silent_p.L186L	NM_015329.3	NP_056144.3	Q9Y6X3	SCC4_HUMAN	MAU2 sister chromatid cohesion factor	186					cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	18						TTGCAGGGCGCTGTTCCTCCT	0.597000													8	16					0	0	1	0	0
CYTH3	9265	broad.mit.edu	37	7	6210502	6210502	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:6210502C>T	ENST00000350796.3	-	8	806	c.670G>A	c.(670-672)Ggc>Agc	p.G224S	CYTH3_ENST00000396741.2_Missense_Mutation_p.G139S|CYTH3_ENST00000488964.1_5'UTR	NM_004227.3	NP_004218.1	O43739	CYH3_HUMAN	cytohesin 3	224					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|urinary_tract(1)	19						TCGTTGATGCCGCGGTTCATG	0.647000													6	12					0	0	1	0	0
YY1	7528	broad.mit.edu	37	14	100705584	100705584	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:100705584G>A	ENST00000262238.4	+	1	263	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	1					cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				CCTCAGCCATGGCCTCGGGCG	0.741000													3	6					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214819539	214819539	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:214819539G>T	ENST00000366955.3	+	13	6794	c.6626G>T	c.(6625-6627)aGg>aTg	p.R2209M		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2305	2 X 177 AA tandem repeats.|Interaction with NDE1 and NDEL1.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GTCACGTTAAGGTCTGAAAAA	0.353000													15	29					7.93312e-07	8.27737e-07	1	1	0
DDOST	1650	broad.mit.edu	37	1	20982022	20982022	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:20982022C>T	ENST00000375048.3	-	5	618	c.513G>A	c.(511-513)acG>acA	p.T171T	DDOST_ENST00000415136.2_Silent_p.T134T|DDOST_ENST00000602624.2_Silent_p.T154T	NM_005216.4	NP_005207.2	P39656	OST48_HUMAN	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)	171					innate immune response|post-translational protein modification|response to cytokine stimulus|T cell activation	integral to membrane|microsome|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|skin(1)	13		all_lung(284;2.98e-05)|Lung NSC(340;3.25e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000141)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00046)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCACGATGAGCGTATGCTGCA	0.527000													14	46					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126212986	126212986	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:126212986G>A	ENST00000373624.2	-	18	1543	c.1342C>T	c.(1342-1344)Cgc>Tgc	p.R448C	DENND1A_ENST00000542603.1_Missense_Mutation_p.R190C|DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000394215.2_Missense_Mutation_p.R418C|DENND1A_ENST00000373620.3_Missense_Mutation_p.R448C|DENND1A_ENST00000394219.3_Missense_Mutation_p.R416C|DENND1A_ENST00000373618.1_Missense_Mutation_p.R416C	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	448						cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						TGCTTCAAGCGGTTTTTCACC	0.368000													7	44					0	0	1	0	0
TRIM5	85363	broad.mit.edu	37	11	5701287	5701287	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5701287C>T	ENST00000305836.5	-	2	423	c.121G>A	c.(121-123)Gca>Aca	p.A41T	TRIM5_ENST00000380027.1_Missense_Mutation_p.A41T|TRIM5_ENST00000380034.3_Missense_Mutation_p.A41T|TRIM5_ENST00000396853.4_Missense_Mutation_p.A41T|TRIM5_ENST00000396855.3_Missense_Mutation_p.A41T|TRIM5_ENST00000396847.3_Missense_Mutation_p.A41T			Q9C035	TRIM5_HUMAN	tripartite motif containing 5	41					interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		TTGTGGTTTGCAGTGAGGCAT	0.552000													29	39					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110510781	110510781	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:110510781C>T	ENST00000378402.5	+	66	10794	c.10690C>T	c.(10690-10692)Cgg>Tgg	p.R3564W		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3564					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGCTGCTCATCGGAGTCCTAG	0.343000										HNSCC(38;0.096)			16	20					0	0	1	0	0
CNTROB	116840	broad.mit.edu	37	17	7842986	7842986	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7842986C>A	ENST00000380262.3	+	8	2008	c.1083C>A	c.(1081-1083)acC>acA	p.T361T	CNTROB_ENST00000563694.1_Silent_p.T361T|CNTROB_ENST00000565740.1_Silent_p.T361T|CNTROB_ENST00000380255.3_Silent_p.T361T	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	361					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				AACGGCAGACCTGGGCCCAGC	0.587000													21	21					1.15919e-05	1.19923e-05	1	1	0
ABCB1	5243	broad.mit.edu	37	7	87179861	87179861	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:87179861G>A	ENST00000265724.3	-	12	1564	c.1147C>T	c.(1147-1149)Cac>Tac	p.H383Y	ABCB1_ENST00000543898.1_Missense_Mutation_p.H319Y	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	383					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCTGGTTTGTGCCCACTCTTC	0.323000													14	94					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98340697	98340697	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:98340697C>T	ENST00000264972.5	+	3	413	c.198C>T	c.(196-198)aaC>aaT	p.N66N		NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	66	SH2 1.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						GCCAGCTCAACGGCACCTACG	0.667000													10	8					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56350205	56350205	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56350205C>A	ENST00000340482.3	-	9	1968	c.1792G>T	c.(1792-1794)Gat>Tat	p.D598Y	MPO_ENST00000225275.3_Missense_Mutation_p.D566Y			P05164	PERM_HUMAN	myeloperoxidase	566					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	CGGATCTCATCCACTGCAATT	0.612000													41	83					1.62957e-23	1.81649e-23	1	1	0
UACA	55075	broad.mit.edu	37	15	70959254	70959254	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:70959254C>A	ENST00000322954.6	-	16	3954	c.3769G>T	c.(3769-3771)Gta>Tta	p.V1257L	UACA_ENST00000560441.1_Missense_Mutation_p.V1242L|UACA_ENST00000539319.1_Missense_Mutation_p.V1148L|UACA_ENST00000379983.2_Missense_Mutation_p.V1244L	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	1257						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						TCCTCACATACTTCCTCATAC	0.333000													6	123					0.000157383	0.000161063	1	1	0
SLC6A19	340024	broad.mit.edu	37	5	1216688	1216688	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1216688G>T	ENST00000304460.10	+	7	959	c.903G>T	c.(901-903)aaG>aaT	p.K301N		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	301					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACTGCGAGAAGGACTCGGTGA	0.607000													11	63					0.00010058	0.000103117	1	1	0
SYNE2	23224	broad.mit.edu	37	14	64637027	64637027	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:64637027C>T	ENST00000357395.3	+	95	17381	c.6237C>T	c.(6235-6237)gaC>gaT	p.D2079D	SYNE2_ENST00000358025.3_Silent_p.D5694D|SYNE2_ENST00000554584.1_Silent_p.D5569D|SYNE2_ENST00000344113.4_Silent_p.D5694D|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000555002.1_Silent_p.D2328D|SYNE2_ENST00000394768.2_Silent_p.D2079D			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5694					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GGAAGGGTGACGTTGATGGGC	0.502000													20	37					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180044193	180044193	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:180044193G>T	ENST00000367607.3	+	28	6022	c.5604G>T	c.(5602-5604)cgG>cgT	p.R1868R		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1868						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TAATGCAACGGCGACAACATG	0.443000													8	6					0.0477658	0.0480142	1	1	0
TEKT2	27285	broad.mit.edu	37	1	36552435	36552435	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:36552435C>T	ENST00000207457.3	+	5	746	c.619C>T	c.(619-621)Cgt>Tgt	p.R207C		NM_014466.2	NP_055281.2	Q9UIF3	TEKT2_HUMAN	tektin 2 (testicular)	207					cell projection organization|microtubule cytoskeleton organization	actin cytoskeleton|cilium axoneme|flagellar axoneme|focal adhesion|microtubule|nucleolus		p.R207C(1)		breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|pancreas(1)|skin(2)	13		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGACCCCACACGTGTACCTGA	0.562000													26	47					0	0	1	0	0
AP1G1	164	broad.mit.edu	37	16	71803538	71803538	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:71803538C>T	ENST00000299980.4	-	6	1071	c.630G>A	c.(628-630)gcG>gcA	p.A210A	AP1G1_ENST00000433195.2_Silent_p.A233A|AP1G1_ENST00000423132.2_Silent_p.A210A|AP1G1_ENST00000393512.3_Silent_p.A210A|AP1G1_ENST00000569748.1_Silent_p.A210A	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	210					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				TTCTGAAATGCGCAAGCATGT	0.383000													4	86					0	0	1	0	0
HPS5	11234	broad.mit.edu	37	11	18318477	18318477	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18318477C>A	ENST00000396253.3	-	11	1498	c.1036G>T	c.(1036-1038)Ggc>Tgc	p.G346C	HPS5_ENST00000438420.2_Missense_Mutation_p.G346C|HPS5_ENST00000531848.1_Missense_Mutation_p.G346C|HPS5_ENST00000349215.3_Missense_Mutation_p.G460C	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	460						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						GACTGACTGCCTCTTCTACTA	0.378000									Hermansky-Pudlak syndrome				23	46					2.89027e-11	3.10618e-11	1	1	0
TYW1B	441250	broad.mit.edu	37	7	72040531	72040531	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:72040531G>A	ENST00000438125.1	-	0	1399							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										GATGTCTTGTGTCCTTGGGAT	0.408000													18	36					0	0	1	0	0
SLC25A23	79085	broad.mit.edu	37	19	6454479	6454479	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6454479G>T	ENST00000301454.4	-	6	756	c.650C>A	c.(649-651)gCc>gAc	p.A217D	SLC25A23_ENST00000334510.5_Missense_Mutation_p.A217D|SLC25A23_ENST00000414491.2_Missense_Mutation_p.A34D	NM_024103.2	NP_077008.2	Q9BV35	SCMC3_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	217					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|pancreas(1)|skin(1)	17						GGTCTTTGAGGCATGGACCTG	0.607000													40	39					8.16277e-20	9.0371e-20	1	1	0
SLC6A10P	0	broad.mit.edu	37	16	32890652	32890652	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:32890652G>A	ENST00000330048.5	-	0	3146					NR_003083.2																						AGTACACAACGTTGAAGATGA	0.632000													10	14					0	0	1	0	0
FAM5B	0	broad.mit.edu	37	1	177250177	177250177	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:177250177C>T	ENST00000361539.4	+	8	2177	c.1865C>T	c.(1864-1866)gCc>gTc	p.A622V	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		622						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						GATGCAGCTGCCCAGTGCCAA	0.522000													12	22					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47047523	47047523	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47047523C>T	ENST00000450053.3	+	43	7068	c.6889C>T	c.(6889-6891)Ctc>Ttc	p.L2297F	NBEAL2_ENST00000292309.5_Missense_Mutation_p.L2113F|NBEAL2_ENST00000383740.2_Missense_Mutation_p.L576F	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2297	BEACH.						binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CGAGGAGGCCCTCAATGTCTT	0.597000													22	47					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129744711	129744711	+	Missense_Mutation	SNP	C	C	T	rs148845897		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:129744711C>T	ENST00000446488.3	-	18	2058	c.1955G>A	c.(1954-1956)cGt>cAt	p.R652H	NFRKB_ENST00000524794.1_Missense_Mutation_p.R677H|NFRKB_ENST00000524746.1_Missense_Mutation_p.R652H|NFRKB_ENST00000304521.5_Missense_Mutation_p.R652H	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	652					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		ACTCCGGTCACGATGCAGGTA	0.478000													28	56					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14924838	14924838	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrY:14924838C>T	ENST00000338981.3	+	31	5405	c.4460C>T	c.(4459-4461)gCt>gTt	p.A1487V	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	1487					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GAACTACCAGCTGAGCAGGCT	0.403000													34	10					0	0	1	0	0
TACR2	6865	broad.mit.edu	37	10	71174882	71174882	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:71174882C>T	ENST00000373306.4	-	2	949	c.406G>A	c.(406-408)Gtc>Atc	p.V136I		NM_001057.2	NP_001048.2	P21452	NK2R_HUMAN	tachykinin receptor 2	136					excretion|muscle contraction	integral to plasma membrane	tachykinin receptor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	11					Clonidine(DB00575)|Octreotide(DB00104)	AAGGGGTGGACGATGGCCATG	0.642000													9	20					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382718	22382718	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:22382718G>T	ENST00000328795.4	+	1	337	c.246G>T	c.(244-246)ttG>ttT	p.L82F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	82					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CCAGGATGTTGGTGGACTTCC	0.512000													35	125					3.54909e-21	3.94031e-21	1	1	0
B4GALT4	8702	broad.mit.edu	37	3	118931506	118931506	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:118931506A>G	ENST00000483209.1	-	8	1566	c.925T>C	c.(925-927)Tca>Cca	p.S309P	B4GALT4_ENST00000393765.2_Missense_Mutation_p.S309P|B4GALT4_ENST00000467604.1_3'UTR|B4GALT4_ENST00000471675.1_Intron|B4GALT4_ENST00000359213.3_Missense_Mutation_p.S309P			O60513	B4GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4	309					membrane lipid metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding|N-acetyllactosamine synthase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(6)|skin(2)|stomach(2)	14				GBM - Glioblastoma multiforme(114;0.222)	N-Acetyl-D-glucosamine(DB00141)	CAGACTCGTGACACTTGGTGT	0.358000													10	16					0	0	1	0	0
MRPL44	65080	broad.mit.edu	37	2	224828620	224828620	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:224828620G>T	ENST00000258383.3	+	3	865	c.796G>T	c.(796-798)Gct>Tct	p.A266S		NM_022915.3	NP_075066.1	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44	266	DRBM.				RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGGCACCACAGCTTTGCCTTT	0.378000													19	32					5.26018e-13	5.704e-13	1	1	0
HIF1A	3091	broad.mit.edu	37	14	62193429	62193429	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:62193429G>A	ENST00000394997.1	+	5	731	c.466G>A	c.(466-468)Gtg>Atg	p.V156M	HIF1A_ENST00000323441.6_Missense_Mutation_p.V155M|HIF1A_ENST00000539097.1_Missense_Mutation_p.V179M|HIF1A_ENST00000337138.4_Missense_Mutation_p.V155M|HIF1A_ENST00000557206.1_3'UTR|HIF1A_ENST00000557538.1_Missense_Mutation_p.V96M|HIF1A-AS2_ENST00000554254.1_lincRNA			Q16665	HIF1A_HUMAN	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	155	Interaction with TSGA10 (By similarity).|PAS 1.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|endometrium(8)|kidney(6)|large_intestine(3)|lung(4)	23				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		ATTAGGCCTTGTGAAAAAGGG	0.343000													16	24					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55987346	55987346	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:55987346C>T	ENST00000263923.4	-	2	374	c.79G>A	c.(79-81)Gtt>Att	p.V27I		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	27					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TCAAGAGAAACACTAGGCAAA	0.348000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			12	35					0	0	1	0	0
MLIP	90523	broad.mit.edu	37	6	54025229	54025229	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:54025229A>G	ENST00000514921.1	+	6	2434	c.2322_splice	c.e6+1	p.E774_splice	MLIP_ENST00000502396.1_Splice_Site_p.E785_splice|MLIP_ENST00000370876.2_Intron|MLIP_ENST00000274897.5_Splice_Site_p.E250_splice|MLIP_ENST00000370877.2_Splice_Site_p.E174_splice|MLIP_ENST00000509997.1_Intron|MLIP_ENST00000511744.1_3'UTR|MLIP_ENST00000358276.5_Intron			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	250						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						CCACCAGTGGAGGTAATAACT	0.413000													19	20					0	0	1	0	0
ZNF775	285971	broad.mit.edu	37	7	150094021	150094021	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150094021C>T	ENST00000329630.5	+	3	559	c.452C>T	c.(451-453)gCg>gTg	p.A151V		NM_173680.3	NP_775951.2	Q96BV0	ZN775_HUMAN	zinc finger protein 775	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(7)|skin(1)	11	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCGAACCTGGCGCGCCACCAG	0.672000													7	10					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103572	53103572	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:53103572C>T	ENST00000408890.4	+	1	224	c.208C>T	c.(208-210)Cgc>Tgc	p.R70C		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	70								p.R70S(1)		endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCAGTGGGGGCGCCCGGTGCC	0.706000													13	21					0	0	1	0	0
ACRV1	56	broad.mit.edu	37	11	125547966	125547966	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:125547966A>G	ENST00000533904.1	-	2	621	c.279T>C	c.(277-279)caT>caC	p.H93H	ACRV1_ENST00000348856.3_Intron|ACRV1_ENST00000353070.1_Intron|ACRV1_ENST00000453509.1_Intron|ACRV1_ENST00000257382.2_Intron|ACRV1_ENST00000345274.1_Intron|ACRV1_ENST00000426183.1_Intron|ACRV1_ENST00000445562.1_Intron|ACRV1_ENST00000433875.1_Silent_p.H93H|ACRV1_ENST00000425431.1_Intron			P26436	ASPX_HUMAN	acrosomal vesicle protein 1	93	3 X 5 AA repeats of S-E-H-[GA]-S.|4 X 4 AA repeats of S-G-E-H.				multicellular organismal development	acrosomal vesicle				kidney(1)|large_intestine(3)|lung(2)	6	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0179)|Lung NSC(97;0.0185)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0713)		CACCTGAAGCATGCTCACTCT	0.542000													4	63					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228547486	228547486	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228547486C>T	ENST00000284548.11	+	81	18967	c.18893C>T	c.(18892-18894)cCc>cTc	p.P6298L	OBSCN_ENST00000366709.4_Missense_Mutation_p.P3417L|OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000570156.2_Intron|OBSCN_ENST00000422127.1_Intron			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7121					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGCCAGAAGCCCGTGGTGCCC	0.706000													6	14					0	0	1	0	0
ZNF382	84911	broad.mit.edu	37	19	37118007	37118007	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:37118007C>T	ENST00000435416.1	+	3	2700	c.1205C>T	c.(1204-1206)aCa>aTa	p.T402I	ZNF382_ENST00000439428.1_Missense_Mutation_p.T402I|ZNF382_ENST00000292928.2_Missense_Mutation_p.T403I|ZNF382_ENST00000423582.1_Missense_Mutation_p.T354I			Q96SR6	ZN382_HUMAN	zinc finger protein 382	403	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGAACTCACACAGGAGAGAAA	0.453000													32	51					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169533417	169533417	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:169533417C>T	ENST00000449804.2	+	1	501	c.456C>T	c.(454-456)taC>taT	p.Y152Y	FOXI1_ENST00000306268.6_Silent_p.Y152Y	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	152					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTACCAGTACGTGGCCGACA	0.602000									Pendred syndrome				6	14					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47674369	47674369	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:47674369A>G	ENST00000397708.1	-	20	4327	c.4073T>C	c.(4072-4074)gTg>gCg	p.V1358A	MCM3AP_ENST00000291688.1_Missense_Mutation_p.V1358A|MCM3AP_ENST00000467026.1_5'UTR|MCM3AP-AS1_ENST00000590829.1_RNA			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1358					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					CTTCCAAAACACATGCTCCTG	0.597000													12	4					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165947857	165947857	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:165947857T>C	ENST00000360093.3	-	28	5299		c.e28-2		SCN3A_ENST00000409101.3_Splice_Site|SCN3A_ENST00000283254.7_Splice_Site|SCN3A_ENST00000540861.1_Splice_Site	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit							voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	GAAACATACCTATGGAAAACA	0.378000													20	30					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39096286	39096286	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39096286C>T	ENST00000591517.1	-	18	1313	c.1285G>A	c.(1285-1287)Gcc>Acc	p.A429T	MAP4K1_ENST00000589130.1_Missense_Mutation_p.A425T|MAP4K1_ENST00000586296.1_Intron|MAP4K1_ENST00000423454.2_Missense_Mutation_p.A91T|MAP4K1_ENST00000396857.2_Missense_Mutation_p.A429T	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	429					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGCCCACTGGCACACCGGACC	0.662000													12	6					0	0	1	0	0
SLC22A5	6584	broad.mit.edu	37	5	131729951	131729951	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:131729951G>A	ENST00000245407.3	+	10	1882	c.1661G>A	c.(1660-1662)aGc>aAc	p.S554N	SLC22A5_ENST00000435065.2_Missense_Mutation_p.S578N	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	554					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	ATCCTTAAAAGCACAGCCTTC	0.418000													35	33					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180003188	180003188	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:180003188C>T	ENST00000367607.3	+	16	4335	c.3917C>T	c.(3916-3918)aCa>aTa	p.T1306I		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1306						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						GCCAGCAGAACAACGACAGAG	0.388000													4	12					0	0	1	0	0
KLF15	28999	broad.mit.edu	37	3	126071361	126071361	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:126071361C>T	ENST00000296233.3	-	2	635	c.405G>A	c.(403-405)cgG>cgA	p.R135R		NM_014079.3	NP_054798.1	Q9UIH9	KLF15_HUMAN	Kruppel-like factor 15	135						nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(7)|ovary(2)|skin(2)	12				GBM - Glioblastoma multiforme(114;0.147)		GCTGGAAGGGCCGTGGGACGT	0.612000													4	21					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46929866	46929866	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:46929866G>A	ENST00000262738.3	-	1	3201	c.3202C>T	c.(3202-3204)Cgg>Tgg	p.R1068W	CELSR1_ENST00000497509.1_5'UTR|CELSR1_ENST00000395964.1_Missense_Mutation_p.R1068W	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1068	Cadherin 8.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ACATACTCCCGCCGGACCTCA	0.612000													15	26					0	0	1	0	0
ANKRD6	22881	broad.mit.edu	37	6	90337305	90337305	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:90337305C>T	ENST00000369408.5	+	13	1619	c.1270C>T	c.(1270-1272)Cgt>Tgt	p.R424C	LYRM2_ENST00000520441.1_Intron|ANKRD6_ENST00000520793.1_Missense_Mutation_p.R400C|ANKRD6_ENST00000339746.4_Missense_Mutation_p.R459C|ANKRD6_ENST00000522441.1_Missense_Mutation_p.R459C|ANKRD6_ENST00000447838.2_Missense_Mutation_p.R459C	NM_001242813.1	NP_001229742.1	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	459							protein binding			NS(1)|endometrium(3)|large_intestine(7)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|stomach(2)	21		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		CTCCTAGATGCGTGTTTTGGA	0.552000													13	17					0	0	1	0	0
GPR62	118442	broad.mit.edu	37	3	51990266	51990266	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:51990266C>T	ENST00000322241.4	+	1	937	c.598C>T	c.(598-600)Cgt>Tgt	p.R200C		NM_080865.3	NP_543141.3	Q9BZJ7	GPR62_HUMAN	G protein-coupled receptor 62	200						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)|upper_aerodigestive_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CGTGGTGGCGCGTCGCGCTGC	0.756000													4	3					0	0	1	0	0
SPHK1	8877	broad.mit.edu	37	17	74382513	74382513	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74382513G>A	ENST00000545180.1	+	7	1107	c.298G>A	c.(298-300)Gcc>Acc	p.A100T	SPHK1_ENST00000323374.4_Missense_Mutation_p.A186T|SPHK1_ENST00000590959.1_Missense_Mutation_p.A114T|SPHK1_ENST00000592299.1_Missense_Mutation_p.A100T|SPHK1_ENST00000392496.3_Missense_Mutation_p.A100T			Q9NYA1	SPHK1_HUMAN	sphingosine kinase 1	100	DAGKc.				'de novo' posttranslational protein folding|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|calcium-mediated signaling|positive regulation of angiogenesis|positive regulation of cell growth|positive regulation of cell migration|positive regulation of fibroblast proliferation|positive regulation of mitotic cell cycle|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|positive regulation of smooth muscle contraction|regulation of tumor necrosis factor-mediated signaling pathway|sphingoid catabolic process|sphingosine metabolic process	cytosol|membrane fraction|nucleus|plasma membrane|soluble fraction	ATP binding|calmodulin binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|DNA binding|magnesium ion binding|protein phosphatase 2A binding|sphinganine kinase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)	11						CTGGGAGACCGCCATCCAGAA	0.657000											OREG0024750	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	22					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	55922477	55922477	+	Missense_Mutation	SNP	G	G	A	rs138285241	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:55922477G>A	ENST00000288221.6	-	14	2759	c.2504C>T	c.(2503-2505)gCg>gTg	p.A835V		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	835						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding	p.A835V(1)		breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GGCCAAGTGCGCTTCTTTTTC	0.532000													70	70					0	0	1	0	0
TRIM62	55223	broad.mit.edu	37	1	33612987	33612987	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33612987G>T	ENST00000291416.5	-	5	1452	c.1219C>A	c.(1219-1221)Ctt>Att	p.L407I	TRIM62_ENST00000543586.1_Missense_Mutation_p.L286I	NM_018207.2	NP_060677.2	Q9BVG3	TRI62_HUMAN	tripartite motif containing 62	407	B30.2/SPRY.					intracellular	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)				CGGACGTTAAGCCGCGTCCAG	0.582000													25	31					4.43304e-23	4.93775e-23	1	1	0
CNKSR1	10256	broad.mit.edu	37	1	26510233	26510233	+	Missense_Mutation	SNP	G	G	A	rs139571283		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26510233G>A	ENST00000361530.6	+	9	912	c.767G>A	c.(766-768)cGt>cAt	p.R256H	CNKSR1_ENST00000531191.1_5'UTR|CNKSR1_ENST00000374253.5_Missense_Mutation_p.R263H			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	263	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		GGATGGCCCCGTAAGAACATG	0.602000													29	35					0	0	1	0	0
CHD6	0	broad.mit.edu	37	20	40126825	40126825	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:40126825G>A	ENST00000373233.3	-	7	1134	c.957C>T	c.(955-957)taC>taT	p.Y319Y	CHD6_ENST00000373222.3_Silent_p.Y354Y|CHD6_ENST00000309279.7_Silent_p.Y319Y	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	319	Chromo 1.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TATACTTAACGTAGAACAGCT	0.383000													17	23					0	0	1	0	0
TEKT3	64518	broad.mit.edu	37	17	15234866	15234866	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:15234866C>T	ENST00000395930.1	-	3	223	c.37G>A	c.(37-39)Gcc>Acc	p.A13T	TEKT3_ENST00000338696.2_Missense_Mutation_p.A13T	NM_031898.2	NP_114104.1	Q9BXF9	TEKT3_HUMAN	tektin 3	13					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				endometrium(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	23				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		CTAGGGTGGGCGTAAGTTGTC	0.433000													9	25					0	0	1	0	0
DUSP8	1850	broad.mit.edu	37	11	1579038	1579038	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:1579038G>A	ENST00000397374.3	-	6	934	c.807C>T	c.(805-807)tcC>tcT	p.S269S	DUSP8_ENST00000528778.1_5'UTR|DUSP8_ENST00000331588.4_Silent_p.S269S	NM_004420.2	NP_004411.2	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	269	Tyrosine-protein phosphatase.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(1)|lung(2)|prostate(1)|urinary_tract(1)	5		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		AGGCGTCGTCGGAGGACATGC	0.622000													6	25					0	0	1	0	0
SLC16A11	162515	broad.mit.edu	37	17	6945091	6945091	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:6945091C>T	ENST00000308009.1	-	4	1660	c.1323G>A	c.(1321-1323)acG>acA	p.T441T	SLC16A11_ENST00000447225.1_Silent_p.T409T	NM_153357.1	NP_699188.1	Q8NCK7	MOT11_HUMAN	solute carrier family 16, member 11	441						integral to membrane|plasma membrane	symporter activity			endometrium(2)|kidney(2)|lung(2)|ovary(1)|skin(2)	9						CTGGGGGAGGCGTGGCTGGAG	0.617000													4	11					0	0	1	0	0
BAG6	7917	broad.mit.edu	37	6	31614220	31614220	+	Missense_Mutation	SNP	C	C	T	rs143680960		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31614220C>T	ENST00000404765.2	-	8	1158	c.869G>A	c.(868-870)cGc>cAc	p.R290H	BAG6_ENST00000375976.4_Missense_Mutation_p.R290H|BAG6_ENST00000362049.6_Missense_Mutation_p.R290H|BAG6_ENST00000211379.5_Missense_Mutation_p.R290H|BAG6_ENST00000439687.2_Missense_Mutation_p.R290H|BAG6_ENST00000375964.6_Missense_Mutation_p.R296H			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	296	4 X 29 AA approximate repeats.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						CTCGTAGTAGCGCTGCAAGAA	0.592000													16	25					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42793372	42793372	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:42793372G>A	ENST00000379274.2	+	27	3241	c.2812G>A	c.(2812-2814)Gaa>Aaa	p.E938K	DGKH_ENST00000540693.1_Missense_Mutation_p.E1074K|DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000337343.4_Missense_Mutation_p.E1074K|DGKH_ENST00000538674.1_Missense_Mutation_p.E829K|DGKH_ENST00000536612.1_Missense_Mutation_p.E938K|DGKH_ENST00000261491.4_Missense_Mutation_p.E1074K			Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta	1074					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		ATAGCAGCTGGAATCGCCACA	0.423000													57	97					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107605029	107605029	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:107605029G>A	ENST00000393561.1	-	12	1922	c.1738C>T	c.(1738-1740)Ctc>Ttc	p.L580F	LAMB1_ENST00000222399.6_Missense_Mutation_p.L556F|LAMB1_ENST00000393560.1_Missense_Mutation_p.L556F			P07942	LAMB1_HUMAN	laminin, beta 1	556	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTTCATAGAGGTAGTGATCC	0.537000													30	61					0	0	1	0	0
SERPINC1	462	broad.mit.edu	37	1	173878765	173878765	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:173878765C>T	ENST00000367698.3	-	5	1196	c.1078G>A	c.(1078-1080)Ggc>Agc	p.G360S		NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	360					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity	p.G360S(1)		NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	AAACTGAAGCCGTCCTCAATG	0.542000													19	45					0	0	1	0	0
BAG6	7917	broad.mit.edu	37	6	31614295	31614295	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31614295G>T	ENST00000404765.2	-	8	1083	c.794C>A	c.(793-795)cCt>cAt	p.P265H	BAG6_ENST00000375976.4_Missense_Mutation_p.P265H|BAG6_ENST00000362049.6_Missense_Mutation_p.P265H|BAG6_ENST00000211379.5_Missense_Mutation_p.P265H|BAG6_ENST00000439687.2_Missense_Mutation_p.P265H|BAG6_ENST00000375964.6_Missense_Mutation_p.P271H			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	271	4 X 29 AA approximate repeats.|Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						CGCAGGGGAAGGATGGCTGTG	0.592000													16	39					1.02788e-11	1.10723e-11	1	1	0
RLF	6018	broad.mit.edu	37	1	40704481	40704481	+	Nonsense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:40704481T>A	ENST00000372771.4	+	8	4134	c.4107T>A	c.(4105-4107)tgT>tgA	p.C1369*		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1369					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			ATAAGGAATGTAATAAACGCT	0.363000													28	39					0	0	1	0	0
ABHD17B	51104	broad.mit.edu	37	9	74481729	74481729	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:74481729C>T	ENST00000333421.6	-	4	952	c.841G>A	c.(841-843)Gtg>Atg	p.V281M	ABHD17B_ENST00000377041.2_Missense_Mutation_p.V281M	NM_001025780.1	NP_001020951.1			abhydrolase domain containing 17B																		TCCTGTGACACAAACTGTTTC	0.398000													7	40					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33405973	33405973	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33405973C>A	ENST00000418600.2	+	8	1392	c.1291C>A	c.(1291-1293)Ctg>Atg	p.L431M	SYNGAP1_ENST00000428982.2_Missense_Mutation_p.L372M|SYNGAP1_ENST00000293748.5_Missense_Mutation_p.L431M|SYNGAP1_ENST00000496374.1_3'UTR	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	431					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						TTATCGGATGCTGTGTGCAGT	0.527000													66	82					2.02796e-37	2.27767e-37	1	1	0
THRA	7067	broad.mit.edu	37	17	38244663	38244663	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38244663G>A	ENST00000450525.2	+	8	1383	c.892G>A	c.(892-894)Gcc>Acc	p.A298T	THRA_ENST00000584985.1_Missense_Mutation_p.A298T|THRA_ENST00000546243.1_Missense_Mutation_p.A298T|THRA_ENST00000394121.4_Missense_Mutation_p.A298T|THRA_ENST00000264637.4_Missense_Mutation_p.A298T	NM_199334.3	NP_955366.1	P10827	THA_HUMAN	thyroid hormone receptor, alpha	298	Ligand-binding.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)	11	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	AGTCTCCGACGCCATCTTTGA	0.587000													65	70					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179478930	179478930	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179478930C>T	ENST00000589042.1	-	262	49418	c.49194G>A	c.(49192-49194)tgG>tgA	p.W16398*	TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.W7525*|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.W14757*|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.W7333*|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.W13830*|TTN_ENST00000359218.5_Nonsense_Mutation_p.W7458*|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14757	Ig-like 100.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGCTTGTGCCACACTTCAC	0.438000													6	27					0	0	1	0	0
TRAF3IP1	26146	broad.mit.edu	37	2	239261531	239261531	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:239261531G>T	ENST00000373327.4	+	13	1737	c.1515G>T	c.(1513-1515)gaG>gaT	p.E505D	TRAF3IP1_ENST00000391993.3_Missense_Mutation_p.E439D|TRAF3IP1_ENST00000391994.2_Missense_Mutation_p.E505D	NM_015650.3	NP_056465.2	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting protein 1	505	DISC1-interaction domain.					cytoplasm|cytoskeleton	protein binding	p.E505E(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(2)	23		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		ACAATGAAGAGGATGATCAAT	0.328000													23	28					3.6726e-16	4.02897e-16	1	1	0
TAGAP	117289	broad.mit.edu	37	6	159457259	159457259	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:159457259G>A	ENST00000367066.3	-	10	2127	c.1796C>T	c.(1795-1797)gCc>gTc	p.A599V	RP1-111C20.4_ENST00000607391.1_RNA|RP1-111C20.4_ENST00000606466.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000606470.1_RNA|TAGAP_ENST00000326965.6_Missense_Mutation_p.A421V	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	599					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		GCCCTGCATGGCCTCTTCATA	0.667000													20	23					0	0	1	0	0
BCL9	607	broad.mit.edu	37	1	147096365	147096365	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:147096365C>T	ENST00000234739.3	+	10	4626	c.3886C>T	c.(3886-3888)Cca>Tca	p.P1296S		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1296	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					AGGTCCAGGGCCAGTGGGAAC	0.597000			T	"""IGH@, IGL@"""	B-ALL								6	22					0	0	1	0	0
UBASH3B	84959	broad.mit.edu	37	11	122680579	122680579	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:122680579C>A	ENST00000284273.5	+	14	2310	c.1935C>A	c.(1933-1935)acC>acA	p.T645T		NM_032873.4	NP_116262.2	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing B	645	Protein tyrosine phosphatase (By similarity).					cytoplasm|nucleus	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|prostate(1)|skin(2)|stomach(2)	26		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		GGAGAGAGACCTTGCTTCAAG	0.458000													17	34					8.28177e-16	9.07663e-16	1	1	0
CFB	629	broad.mit.edu	37	6	31917903	31917903	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31917903G>A	ENST00000456570.1	+	23	3046	c.2991G>A	c.(2989-2991)tgG>tgA	p.W997*	CFB_ENST00000425368.2_Nonsense_Mutation_p.W495*|CFB_ENST00000477310.1_Nonsense_Mutation_p.W846*|CFB_ENST00000556679.1_Nonsense_Mutation_p.W997*			P00751	CFAB_HUMAN	complement factor B	495					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						AGCAACCATGGCAGGCCAAGA	0.512000													30	39					0	0	1	0	0
CRYBG3	131544	broad.mit.edu	37	3	97596502	97596502	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:97596502C>T	ENST00000182096.4	+	1	684	c.620C>T	c.(619-621)gCa>gTa	p.A207V		NM_153605.3	NP_705833.3			beta-gamma crystallin domain containing 3											breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(10)|stomach(1)|upper_aerodigestive_tract(2)	32						GAGGAGGAGGCAGCAGTATTG	0.468000													14	21					0	0	1	0	0
PLAGL2	5326	broad.mit.edu	37	20	30785232	30785232	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:30785232G>A	ENST00000246229.4	-	3	778	c.514C>T	c.(514-516)Cta>Tta	p.L172L		NM_002657.3	NP_002648.1	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	172						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|liver(1)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGGTGCTCTAGCAGGGCCTGG	0.632000													7	3					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71492735	71492735	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:71492735G>A	ENST00000296755.7	+	5	3851	c.3553G>A	c.(3553-3555)Gga>Aga	p.G1185R		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1185						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ACCGCTCAACGGATTTTCTGA	0.423000													28	20					0	0	1	0	0
LCAT	3931	broad.mit.edu	37	16	67976325	67976325	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67976325A>G	ENST00000264005.5	-	5	718	c.689T>C	c.(688-690)tTc>tCc	p.F230S		NM_000229.1	NP_000220.1	P04180	LCAT_HUMAN	lecithin-cholesterol acyltransferase	230					cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|reverse cholesterol transport|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein A-I binding|phosphatidylcholine-sterol O-acyltransferase activity			cervix(4)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)	16		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00418)|Epithelial(162;0.0183)|all cancers(182;0.12)		AAGAGAGATGAAGCCATCAAT	0.582000													11	16					0	0	1	0	0
PELI2	57161	broad.mit.edu	37	14	56746451	56746451	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:56746451G>A	ENST00000267460.4	+	3	551	c.265G>A	c.(265-267)Gtg>Atg	p.V89M		NM_021255.2	NP_067078.1	Q9HAT8	PELI2_HUMAN	pellino E3 ubiquitin protein ligase family member 2	89					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			kidney(6)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	22						GAATCAGACTGTGGTGGTGGA	0.308000													40	59					0	0	1	0	0
CTC-260F20.3	0	broad.mit.edu	37	19	19645851	19645851	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19645851G>A	ENST00000555938.1	+	5	336	c.324G>A	c.(322-324)ccG>ccA	p.P108P	YJEFN3_ENST00000514277.3_Silent_p.P109P|YJEFN3_ENST00000436027.4_Silent_p.P59P																							AGGCGTTCCCGTTGCCCGCTC	0.657000													14	104					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814118	106814118	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:106814118C>T	ENST00000407775.2	+	8	2058	c.1808C>T	c.(1807-1809)tCc>tTc	p.S603F	ZFPM2_ENST00000378472.4_Missense_Mutation_p.S334F|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.S471F|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.S471F|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	603					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GGCCAAACCTCCATAAACCTT	0.468000													38	45					0	0	1	0	0
ZNF143	7702	broad.mit.edu	37	11	9492877	9492877	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:9492877C>T	ENST00000396602.2	+	2	141	c.22C>T	c.(22-24)Cga>Tga	p.R8*	ZNF143_ENST00000530463.1_Nonsense_Mutation_p.R8*|ZNF143_ENST00000396604.1_Nonsense_Mutation_p.R8*|ZNF143_ENST00000396597.3_Nonsense_Mutation_p.R8*|ZNF143_ENST00000299606.2_Nonsense_Mutation_p.R8*	NM_003442.5	NP_003433.3	P52747	ZN143_HUMAN	zinc finger protein 143	8					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding			endometrium(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	13				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		CCAAATAAATCGAGATTCTCA	0.418000													13	27					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24350743	24350743	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:24350743G>A	ENST00000175238.6	+	16	1925		c.e16+1		ADAM7_ENST00000380789.1_Splice_Site|RP11-624C23.1_ENST00000519689.1_RNA|ADAM7_ENST00000520720.1_Splice_Site|RP11-561E1.1_ENST00000519364.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7						proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		AGAGGGAATGGTAAGACAAAA	0.358000													13	29					0	0	1	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21935361	21935361	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:21935361C>T	ENST00000542643.2	-	17	1442	c.1140G>A	c.(1138-1140)gaG>gaA	p.E380E	RAP1GAP_ENST00000374761.2_Silent_p.E411E|RAP1GAP_ENST00000374763.2_Silent_p.E380E|RAP1GAP_ENST00000290101.4_Silent_p.E444E|RAP1GAP_ENST00000374765.4_Silent_p.E380E	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	380	Rap-GAP.				regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		TGGCAAACTTCTCTGCCTTGT	0.512000													70	126					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2978406	2978406	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2978406G>A	ENST00000396946.4	-	7	1327	c.924C>T	c.(922-924)gaC>gaT	p.D308D		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	308					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CCTCCTTGCGGTCGTGTTCCA	0.647000			Mis		DLBCL								6	25					0	0	1	0	0
GALNT3	2591	broad.mit.edu	37	2	166613680	166613680	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166613680A>G	ENST00000392701.3	-	7	2044	c.1269T>C	c.(1267-1269)caT>caC	p.H423H	GALNT3_ENST00000409882.1_Silent_p.H161H	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	423					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						TTGGAAAGCTATGAGGGCTTT	0.403000													31	37					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44463274	44463274	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:44463274C>T	ENST00000372310.3	-	14	2010	c.1845G>A	c.(1843-1845)gcG>gcA	p.A615A	SLC6A9_ENST00000357730.2_Silent_p.A634A|SLC6A9_ENST00000475075.2_Silent_p.A504A|SLC6A9_ENST00000360584.2_Silent_p.A688A|SLC6A9_ENST00000372307.3_Intron|SLC6A9_ENST00000372306.3_Intron	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	688						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity	p.A688A(1)|p.A615A(1)		endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	TGGGGATCTGCGCCTTGTCCG	0.692000													16	76					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184045675	184045675	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:184045675C>T	ENST00000342981.4	+	25	4255	c.3841C>T	c.(3841-3843)Cgg>Tgg	p.R1281W	EIF4G1_ENST00000350481.5_Missense_Mutation_p.R1116W|EIF4G1_ENST00000352767.3_Missense_Mutation_p.R1287W|EIF4G1_ENST00000435046.2_Missense_Mutation_p.R1084W|EIF4G1_ENST00000427845.1_Missense_Mutation_p.R1194W|EIF4G1_ENST00000424196.1_Missense_Mutation_p.R1287W|EIF4G1_ENST00000414031.1_Missense_Mutation_p.R1240W|EIF4G1_ENST00000411531.1_Missense_Mutation_p.R1241W|EIF4G1_ENST00000346169.2_Missense_Mutation_p.R1280W|EIF4G1_ENST00000392537.2_Missense_Mutation_p.R1193W|EIF4G1_ENST00000441154.1_Missense_Mutation_p.R1117W|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000434061.2_Missense_Mutation_p.R1085W|EIF4G1_ENST00000382330.3_Missense_Mutation_p.R1287W|EIF4G1_ENST00000319274.6_Missense_Mutation_p.R1280W	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	1280	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CATCTTTGTACGGCATGGTGT	0.602000													19	35					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57751078	57751078	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:57751078T>C	ENST00000269122.3	+	15	2637	c.2363T>C	c.(2362-2364)gTg>gCg	p.V788A	CLTC_ENST00000393043.1_Missense_Mutation_p.V788A|CLTC_ENST00000579456.1_Intron|CLTC_ENST00000579815.1_3'UTR	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	788	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CATGATTTGGTGCTCTATTTA	0.294000			T	"""ALK, TFE3"""	"""ALCL, renal """								17	22					0	0	1	0	0
ZNF890P	0	broad.mit.edu	37	7	5167333	5167333	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:5167333C>T	ENST00000422060.2	-	0	518					NR_034163.1																						GCCACTCTTTCCGGGTGAAGC	0.577000													4	9					0	0	1	0	0
CNTNAP3B	728577	broad.mit.edu	37	9	43816768	43816768	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:43816768A>G	ENST00000377564.3	+	6	1267	c.874A>G	c.(874-876)Act>Gct	p.T292A	CNTNAP3B_ENST00000276974.6_Missense_Mutation_p.T292A	NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	292	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						GGACAAACACACTCATCATTT	0.433000													18	85					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10438444	10438444	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:10438444C>T	ENST00000245503.5	-	19	2510	c.2126G>A	c.(2125-2127)cGc>cAc	p.R709H	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.R709H	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	709	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CCTACAGATGCGGATGCCTTC	0.433000													18	52					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102843240	102843240	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:102843240G>A	ENST00000359520.7	+	2	408	c.182G>A	c.(181-183)tGc>tAc	p.C61Y	TECPR2_ENST00000561228.1_3'UTR|TECPR2_ENST00000558678.1_Missense_Mutation_p.C61Y	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	61							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						TATCTGTACTGCCGGCACCTC	0.557000													11	11					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12387744	12387744	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12387744C>T	ENST00000358136.3	+	36	8160	c.8030C>T	c.(8029-8031)gCg>gTg	p.A2677V	VPS13D_ENST00000356315.4_Missense_Mutation_p.A2677V	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2677					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTTAAGAATGCGGAACCTCTG	0.502000													61	124					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247694914	247694914	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247694914G>A	ENST00000366487.3	-	2	1261	c.900C>T	c.(898-900)agC>agT	p.S300S	GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000463359.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			GCCGGAGGGCGCTCTTCACCT	0.522000													17	32					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62026114	62026114	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62026114G>A	ENST00000435607.1	-	16	3077	c.3001C>T	c.(3001-3003)Cgc>Tgc	p.R1001C	SCN4A_ENST00000578147.1_Missense_Mutation_p.R1001C	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1001					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CAGGGCCAGCGCTGCACGCAG	0.642000													8	13					0	0	1	0	0
LCE2B	26239	broad.mit.edu	37	1	152659385	152659385	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:152659385A>G	ENST00000368780.3	+	2	120	c.66A>G	c.(64-66)ccA>ccG	p.P22P	LCE2B_ENST00000417924.2_Silent_p.P22P	NM_014357.4	NP_055172.1	O14633	LCE2B_HUMAN	late cornified envelope 2B	22	Cys-rich.|Pro-rich.				keratinization					endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	11	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGTACCCCAAAATGTCCAC	0.547000													4	102					0	0	1	0	0
TTC17	55761	broad.mit.edu	37	11	43513610	43513610	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:43513610C>T	ENST00000039989.4	+	23	3205	c.3191C>T	c.(3190-3192)gCc>gTc	p.A1064V		NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	1064							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						TTGCACAATGCCAAGCTCTGG	0.498000													63	84					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84751069	84751069	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:84751069G>A	ENST00000284136.6	-	1	182	c.139C>T	c.(139-141)Cta>Tta	p.L47L	SEMA3D_ENST00000444867.1_Silent_p.L47L	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	47	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TTGTAGGTTAGCTTGAGTCTT	0.299000													13	23					0	0	1	0	0
METTL23	124512	broad.mit.edu	37	17	74729657	74729657	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74729657C>T	ENST00000341249.6	+	5	794	c.462C>T	c.(460-462)caC>caT	p.H154H	METTL23_ENST00000588302.1_3'UTR|RP11-318A15.7_ENST00000587459.1_Intron|METTL23_ENST00000591571.1_3'UTR|METTL23_ENST00000586752.1_Silent_p.H87H|METTL23_ENST00000586738.1_3'UTR|METTL23_ENST00000590964.1_Silent_p.H87H|METTL23_ENST00000586200.1_Silent_p.H35H|METTL23_ENST00000588783.1_3'UTR|METTL23_ENST00000588822.1_Silent_p.H87H	NM_001206984.1	NP_001193913.1	Q86XA0	MET23_HUMAN	methyltransferase like 23	154						integral to membrane	methyltransferase activity			large_intestine(2)|lung(1)	3						AATGTGTCCACATTCCTCTTG	0.368000													41	90					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10934954	10934954	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:10934954C>T	ENST00000298232.7	-	14	1152	c.785G>A	c.(784-786)cGa>cAa	p.R262Q	TPTE_ENST00000361285.4_Missense_Mutation_p.R280Q|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.R242Q	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	280	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R262Q(1)|p.R262L(1)|p.R280L(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTGTAGACTCGATAGTGGTT	0.333000													20	150					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4927006	4927006	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4927006C>T	ENST00000320785.5	+	23	3229	c.2872C>T	c.(2872-2874)Cgg>Tgg	p.R958W		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	958				SGGRGGGL -> LWGPGRGV (in Ref. 1; AAC52117).	microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						CTCTGGGGGCCGGGGCGGGGG	0.687000													21	13					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47835606	47835606	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:47835606G>A	ENST00000289672.2	-	55	8386	c.8336C>T	c.(8335-8337)gCt>gTt	p.A2779V	C7orf69_ENST00000258776.4_Intron|C7orf69_ENST00000418326.2_Intron	NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2779					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AACCATCTCAGCCTCTTCCAA	0.398000													11	61					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7415850	7415850	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7415850C>T	ENST00000322644.6	+	27	4946	c.4547C>T	c.(4546-4548)gCc>gTc	p.A1516V		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1516					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				ATCTCTCCTGCCATGACACCT	0.572000													20	28					0	0	1	0	0
LGMN	5641	broad.mit.edu	37	14	93182559	93182559	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:93182559G>A	ENST00000393218.2	-	6	663	c.326C>T	c.(325-327)aCc>aTc	p.T109I	LGMN_ENST00000555699.1_Missense_Mutation_p.T109I|LGMN_ENST00000334869.4_Missense_Mutation_p.T109I|LGMN_ENST00000557434.1_Missense_Mutation_p.T109I	NM_001008530.2	NP_001008530.1	Q99538	LGMN_HUMAN	legumain	109					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|skin(2)	18		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		ATTTTGTGGGGTAACATCCTA	0.507000													41	73					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136259426	136259426	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136259426C>T	ENST00000371957.3	+	8	699	c.592C>T	c.(592-594)Cgt>Tgt	p.R198C	C9orf96_ENST00000371955.1_5'UTR	NM_153710.3	NP_714921.3	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	198	Protein kinase.						ATP binding|protein kinase activity	p.R198C(1)		autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		AGACCCCTTTCGTAAGTCCTG	0.567000													38	68					0	0	1	0	0
DCPS	28960	broad.mit.edu	37	11	126215288	126215288	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:126215288T>C	ENST00000263579.4	+	6	1123	c.794T>C	c.(793-795)gTa>gCa	p.V265A	DCPS_ENST00000530860.1_3'UTR	NM_014026.3	NP_054745.1	Q96C86	DCPS_HUMAN	decapping enzyme, scavenger	265					deadenylation-dependent decapping of nuclear-transcribed mRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	exoribonuclease activity|protein binding			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00949)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.08)		CATCTGCGAGTATACCTGCAC	0.662000													12	38					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131092213	131092213	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:131092213G>A	ENST00000357668.1	-	25	2604	c.2577C>T	c.(2575-2577)aaC>aaT	p.N859N	ASAP1_ENST00000518721.1_Silent_p.N859N			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	859	Pro-rich.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						GACCCCCATCGTTACCTACAA	0.468000													39	64					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47891423	47891423	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47891423G>A	ENST00000446256.2	+	23	3853	c.3281G>A	c.(3280-3282)cGt>cAt	p.R1094H	DHX30_ENST00000445061.1_Missense_Mutation_p.R1133H|DHX30_ENST00000348968.4_Missense_Mutation_p.R1105H|DHX30_ENST00000457607.1_Missense_Mutation_p.R1161H	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	1133						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GGTGACTCGCGTACCGTGCGG	0.677000											OREG0015550	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	23					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28483803	28483803	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28483803C>T	ENST00000261609.7	-	24	3801	c.3693G>A	c.(3691-3693)aaG>aaA	p.K1231K		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1231	Cytochrome b5 heme-binding.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TATCATACACCTTCCCGTCAA	0.373000													3	45					0	0	1	0	0
GJB6	0	broad.mit.edu	37	13	20797027	20797027	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:20797027G>A	ENST00000356192.6	-	5	1213	c.593C>T	c.(592-594)gCg>gTg	p.A198V	GJB6_ENST00000400066.3_Missense_Mutation_p.A198V|GJB6_ENST00000400065.3_Missense_Mutation_p.A198V|GJB6_ENST00000241124.6_Missense_Mutation_p.A198V	NM_001110219.2	NP_001103689.1	O95452	CXB6_HUMAN	gap junction protein, beta 6, 30kDa	198					cell communication|sensory perception of sound	connexon complex|integral to membrane|intracellular membrane-bounded organelle				biliary_tract(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	9		all_cancers(29;2.04e-22)|all_epithelial(30;1.19e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;2.17e-05)|Epithelial(112;0.00075)|OV - Ovarian serous cystadenocarcinoma(117;0.00978)|Lung(94;0.0238)|GBM - Glioblastoma multiforme(144;0.0323)|LUSC - Lung squamous cell carcinoma(192;0.0744)		AATCACAGACGCAGAAATCAT	0.448000													19	28					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177069450	177069450	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:177069450G>A	ENST00000393643.2	+	13	2113	c.1861G>A	c.(1861-1863)Gtg>Atg	p.V621M	WDR17_ENST00000280190.4_Missense_Mutation_p.V645M|WDR17_ENST00000507824.2_Missense_Mutation_p.V628M|WDR17_ENST00000508596.1_Missense_Mutation_p.V621M	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	645										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		AGGAACTTGTGTGGATACTGT	0.373000													29	51					0	0	1	0	0
TTLL9	164395	broad.mit.edu	37	20	30507689	30507689	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:30507689G>A	ENST00000375938.4	+	7	780	c.527G>A	c.(526-528)gGc>gAc	p.G176D	TTLL9_ENST00000375922.4_Intron|TTLL9_ENST00000375934.4_Missense_Mutation_p.G158D|TTLL9_ENST00000375921.2_Intron|TTLL9_ENST00000535842.1_Missense_Mutation_p.G176D|TTLL9_ENST00000310998.4_Missense_Mutation_p.G126D			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	176	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CAAGGGAAAGGCATCTTCCTC	0.622000													13	27					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48457572	48457572	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48457572G>A	ENST00000358536.4	-	18	3754	c.3485C>T	c.(3484-3486)cCg>cTg	p.P1162L	PLXNB1_ENST00000358459.4_Missense_Mutation_p.P979L|PLXNB1_ENST00000296440.6_Missense_Mutation_p.P1162L|PLXNB1_ENST00000448774.2_Intron|PLXNB1_ENST00000456774.1_Missense_Mutation_p.P979L	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1162	IPT/TIG 2.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATGGACCTTCGGATCCTGTGG	0.647000													3	6					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26582334	26582334	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26582334G>A	ENST00000252992.4	+	4	1012	c.881G>A	c.(880-882)cGt>cAt	p.R294H	CEP85_ENST00000451429.2_Missense_Mutation_p.R243H	NM_022778.2	NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	294						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						GAATTGATTCGTTTACAGATG	0.463000													23	29					0	0	1	0	0
IL19	29949	broad.mit.edu	37	1	206972299	206972299	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:206972299G>A	ENST00000340758.2	+	1	85	c.60G>A	c.(58-60)gtG>gtA	p.V20V		NM_153758.2	NP_715639.1	Q9UHD0	IL19_HUMAN	interleukin 19	0					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			central_nervous_system(2)|large_intestine(1)|lung(2)|ovary(1)|stomach(1)	7			BRCA - Breast invasive adenocarcinoma(75;0.211)			TCACACATGTGCACACACATA	0.527000													19	29					0	0	1	0	0
TPRA1	131601	broad.mit.edu	37	3	127298945	127298945	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:127298945C>T	ENST00000355552.3	-	2	421	c.45G>A	c.(43-45)gcG>gcA	p.A15A	TPRA1_ENST00000296210.7_Silent_p.A15A|TPRA1_ENST00000450633.2_Silent_p.A15A|TPRA1_ENST00000489960.1_Silent_p.A15A	NM_001136053.1	NP_001129525.1	Q86W33	TPRA1_HUMAN	transmembrane protein, adipocyte asscociated 1	15					aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity			endometrium(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	9						GTGGGGGTAGCGCTGTGCTCC	0.642000													7	18					0	0	1	0	0
AGFG1	3267	broad.mit.edu	37	2	228399714	228399714	+	Missense_Mutation	SNP	C	C	T	rs142955065	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:228399714C>T	ENST00000310078.7	+	8	1438	c.1178C>T	c.(1177-1179)gCg>gTg	p.A393V	AGFG1_ENST00000373671.3_Missense_Mutation_p.A353V|AGFG1_ENST00000409171.1_Missense_Mutation_p.A393V|AGFG1_ENST00000409315.1_Missense_Mutation_p.A372V|AGFG1_ENST00000409979.2_Missense_Mutation_p.A417V	NM_001135188.1|NM_004504.4	NP_001128660.1|NP_004495.2	P52594	AGFG1_HUMAN	ArfGAP with FG repeats 1	393					cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(2)|ovary(1)|prostate(1)|skin(4)|stomach(1)	18						TCCAGTAATGCGTATACTTCC	0.418000													20	28					0	0	1	0	0
MUS81	80198	broad.mit.edu	37	11	65633303	65633303	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65633303C>A	ENST00000308110.4	+	15	1876	c.1527C>A	c.(1525-1527)gcC>gcA	p.A509A	MUS81_ENST00000533035.1_Silent_p.A434A	NM_025128.4	NP_079404.3	Q96NY9	MUS81_HUMAN	MUS81 structure-specific endonuclease subunit	509					DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	13				READ - Rectum adenocarcinoma(159;0.166)		CCTATGATGCCTGTGCCACCC	0.632000								Homologous recombination					20	38					1.55795e-14	1.69983e-14	1	1	0
RGL3	57139	broad.mit.edu	37	19	11527598	11527598	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11527598C>T	ENST00000380456.3	-	3	346	c.283G>A	c.(283-285)Gcc>Acc	p.A95T	RGL3_ENST00000393423.3_Missense_Mutation_p.A95T	NM_001035223.2|NM_001161616.1	NP_001030300.2|NP_001155088.1	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation stimulator-like 3	95	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				breast(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(1)|skin(1)	18						GCCAGGAAGGCGGGCATGAAG	0.652000													8	29					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186332113	186332113	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:186332113C>T	ENST00000367478.3	-	6	848	c.552G>A	c.(550-552)gaG>gaA	p.E184E	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	184					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CCTTTTCTTGCTCCAAGCGTT	0.348000			T	NTRK1	papillary thyroid								12	18					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187173195	187173195	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:187173195G>A	ENST00000264690.6	+	11	1356	c.1169G>A	c.(1168-1170)cGc>cAc	p.R390H	KLKB1_ENST00000513864.1_Missense_Mutation_p.R390H	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	390					blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity	p.R390H(2)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		ACAAGCACACGCATTGTTGGA	0.502000													6	61					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25886785	25886785	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:25886785C>T	ENST00000376351.3	+	11	2589	c.2230C>T	c.(2230-2232)Cgg>Tgg	p.R744W	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	744						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R744W(1)		breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CCAGAAAAAGCGGTGCTCGAA	0.498000													35	50					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50143074	50143074	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50143074C>T	ENST00000347869.3	+	10	962	c.787C>T	c.(787-789)Cgc>Tgc	p.R263C		NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	263	RRM 2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CAATAACATCCGCCTCATAAA	0.473000													6	92					0	0	1	0	0
PPP3CB	5532	broad.mit.edu	37	10	75234727	75234727	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:75234727C>T	ENST00000360663.5	-	4	584	c.473G>A	c.(472-474)gGc>gAc	p.G158D	PPP3CB_ENST00000394829.2_Missense_Mutation_p.G158D|PPP3CB_ENST00000545874.1_Missense_Mutation_p.G72D|PPP3CB_ENST00000342558.3_Missense_Mutation_p.G158D|PPP3CB_ENST00000394828.2_Missense_Mutation_p.G158D|PPP3CB_ENST00000394822.2_Missense_Mutation_p.G176D			P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta isozyme	158	Catalytic.									breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(7)|skin(1)|urinary_tract(1)	22	Prostate(51;0.0119)					TTCATGGTTGCCTCTCAGAAG	0.348000													14	25					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77290768	77290768	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:77290768T>C	ENST00000388914.3	-	10	1310	c.1158A>G	c.(1156-1158)ctA>ctG	p.L386L		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	386										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						CCCTTTTGTGTAGATCAGCCT	0.418000													10	36					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113704168	113704168	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:113704168C>T	ENST00000003302.4	-	7	801	c.733G>A	c.(733-735)Gca>Aca	p.A245T	USP28_ENST00000260188.5_Missense_Mutation_p.A245T|USP28_ENST00000545540.1_Missense_Mutation_p.A120T|USP28_ENST00000542033.1_5'UTR|USP28_ENST00000537706.1_Missense_Mutation_p.A245T	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	245					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		GATCGGAATGCTCCCTTTAAT	0.408000													35	57					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19746242	19746242	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19746242G>A	ENST00000203556.4	-	15	1679	c.1542C>T	c.(1540-1542)agC>agT	p.S514S	GMIP_ENST00000587238.1_Silent_p.S488S|GMIP_ENST00000586269.1_5'UTR|GMIP_ENST00000445806.2_Silent_p.S485S	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	514					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						ACTCCGTCCCGCTGACCATGA	0.612000													18	26					0	0	1	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21924989	21924989	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:21924989C>T	ENST00000542643.2	-	24	2163	c.1861G>A	c.(1861-1863)Gtg>Atg	p.V621M	RAP1GAP_ENST00000374761.2_Missense_Mutation_p.V626M|RAP1GAP_ENST00000374763.2_Missense_Mutation_p.V680M|RAP1GAP_ENST00000290101.4_Missense_Mutation_p.V659M|RAP1GAP_ENST00000374765.4_Missense_Mutation_p.V595M	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	595					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		GAGGATGACACGCTCTCCTGG	0.622000													6	30					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76805865	76805865	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:76805865C>T	ENST00000286719.7	-	8	984	c.628G>A	c.(628-630)Gtg>Atg	p.V210M		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	210	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CCTCGATCCACAAAGTCACCG	0.453000													35	166					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1217047	1217047	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1217047C>T	ENST00000304460.10	+	8	1216	c.1160C>T	c.(1159-1161)gCc>gTc	p.A387V		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	387					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GACATCAACGCCTTCCTCTCA	0.657000													25	53					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9224815	9224815	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:9224815G>A	ENST00000382496.5	-	8	1282	c.617C>T	c.(616-618)aCg>aTg	p.T206M		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	206	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GTACTGCGCCGTGCGGAGAGG	0.512000													11	12					0	0	1	0	0
ATL2	64225	broad.mit.edu	37	2	38525431	38525431	+	Missense_Mutation	SNP	C	C	T	rs114096962	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:38525431C>T	ENST00000378954.4	-	12	1488	c.1487G>A	c.(1486-1488)gGc>gAc	p.G496D	ATL2_ENST00000539122.1_Missense_Mutation_p.G325D|ATL2_ENST00000406122.1_Missense_Mutation_p.G325D|ATL2_ENST00000402054.1_Missense_Mutation_p.G325D|ATL2_ENST00000419554.2_Missense_Mutation_p.G496D|ATL2_ENST00000332337.4_Missense_Mutation_p.G478D|ATL2_ENST00000452935.2_Missense_Mutation_p.G478D|ATL2_ENST00000546051.1_Missense_Mutation_p.G325D	NM_001135673.1|NM_022374.2	NP_001129145.1|NP_071769.2	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2	496					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22						AGAGTTTAGGCCAATGAAGCC	0.418000													20	29					0	0	1	0	0
EMC1	23065	broad.mit.edu	37	1	19559589	19559589	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:19559589C>T	ENST00000477853.1	-	14	1515	c.1473G>A	c.(1471-1473)caG>caA	p.Q491Q	RP1-43E13.2_ENST00000437898.1_RNA|EMC1_ENST00000375199.3_Silent_p.Q490Q|EMC1_ENST00000375208.3_Silent_p.Q469Q	NM_001271428.1|NM_015047.1	NP_001258357.1|NP_055862.1			ER membrane protein complex subunit 1																		GCAGGATAAGCTGAGACGAGA	0.473000													25	46					0	0	1	0	0
PLSCR2	57047	broad.mit.edu	37	3	146167020	146167020	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:146167020G>A	ENST00000497985.1	-	8	1276	c.837C>T	c.(835-837)gcC>gcT	p.A279A	PLSCR2_ENST00000336685.2_Silent_p.A206A	NM_001199978.1	NP_001186907.1	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	206					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity			endometrium(2)|large_intestine(5)|lung(7)|stomach(1)	15						CAATCATCACGGCTTTCATTT	0.383000													47	56					0	0	1	0	0
TMCO3	55002	broad.mit.edu	37	13	114201677	114201677	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:114201677T>C	ENST00000434316.2	+	11	2112	c.1753T>C	c.(1753-1755)Tca>Cca	p.S585P	TMCO3_ENST00000375391.1_Intron	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	585						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			CCTCACCTTGTCAGTGGTGGT	0.612000													26	35					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34856988	34856988	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:34856988G>A	ENST00000431794.3	-	22	2690	c.2168C>T	c.(2167-2169)gCc>gTc	p.A723V	MYO19_ENST00000268852.9_Missense_Mutation_p.A523V	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	723						mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ACCAGTTATGGCTGCTGCCTG	0.582000													31	38					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176860173	176860173	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176860173G>A	ENST00000355472.5	+	6	634	c.466G>A	c.(466-468)Gcc>Acc	p.A156T	GRK6_ENST00000355958.5_Missense_Mutation_p.A156T|GRK6_ENST00000528793.1_Missense_Mutation_p.A156T|GRK6_ENST00000393576.3_Missense_Mutation_p.A156T|GRK6_ENST00000507633.1_Missense_Mutation_p.A156T	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	156	N-terminal.|RGS.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTGAGCGTGGCCCCTTTTGC	0.632000													24	32					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146266673	146266673	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:146266673G>A	ENST00000367503.3	-	8	1820	c.1422C>T	c.(1420-1422)taC>taT	p.Y474Y	SHPRH_ENST00000275233.7_Silent_p.Y474Y|SHPRH_ENST00000367505.2_Silent_p.Y474Y|SHPRH_ENST00000438092.2_Silent_p.Y474Y	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	474	H15.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GTTGAACATCGTATCTATATA	0.378000													4	44					0	0	1	0	0
SIM2	6493	broad.mit.edu	37	21	38072205	38072205	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:38072205C>T	ENST00000290399.6	+	1	772	c.159C>T	c.(157-159)cgC>cgT	p.R53R	SIM2_ENST00000430056.3_Silent_p.R53R|AP000697.6_ENST00000430607.1_RNA|SIM2_ENST00000460783.1_3'UTR	NM_005069.3	NP_005060.1	Q14190	SIM2_HUMAN	single-minded family bHLH transcription factor 2	53	Helix-loop-helix motif.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(6)|prostate(1)|skin(2)	16						TGAAGATGCGCGCCGTCTTCC	0.697000													7	1					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43896661	43896661	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43896661C>T	ENST00000562955.1	+	32	4645	c.4645C>T	c.(4645-4647)Cga>Tga	p.R1549*	SZT2_ENST00000372442.1_Nonsense_Mutation_p.R707*	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1606						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						AGTTGGAGGCCGAGTTCCCTT	0.602000													16	23					0	0	1	0	0
SUN5	140732	broad.mit.edu	37	20	31571729	31571729	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31571729C>T	ENST00000356173.3	-	13	1103	c.1011G>A	c.(1009-1011)gcG>gcA	p.A337A	SUN5_ENST00000375523.3_Silent_p.A312A	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	337	SUN.				spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						TCACCTTGACCGCACTGAAAG	0.607000													30	51					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48753279	48753279	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48753279C>T	ENST00000285238.8	+	22	2975	c.2895C>T	c.(2893-2895)gcC>gcT	p.A965A	ABCC3_ENST00000510891.1_3'UTR	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	965					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	ATGCCAAGGCCGTGGGGCTCT	0.592000													18	15					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77272943	77272943	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:77272943C>T	ENST00000251089.2	-	5	1308	c.1196G>A	c.(1195-1197)cGg>cAg	p.R399Q		NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	399										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		GACATCGCCCCGGCGTGGGTT	0.592000													11	24					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125154676	125154676	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:125154676C>T	ENST00000362012.2	+	11	1658	c.1653C>T	c.(1651-1653)ggC>ggT	p.G551G	PTGS1_ENST00000373698.5_Silent_p.G442G|PTGS1_ENST00000540753.1_Silent_p.G489G|PTGS1_ENST00000223423.4_Silent_p.G514G	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	551					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	CATTTGGCGGCGAGGTGGGCT	0.552000													33	39					0	0	1	0	0
CLCN2	1181	broad.mit.edu	37	3	184075770	184075770	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:184075770C>T	ENST00000265593.4	-	5	766	c.595G>A	c.(595-597)Ggg>Agg	p.G199R	CLCN2_ENST00000434054.2_Missense_Mutation_p.G155R|CLCN2_ENST00000423355.2_5'UTR|EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000344937.7_Missense_Mutation_p.G199R|CLCN2_ENST00000457512.1_Missense_Mutation_p.G199R	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	199			G -> A (no effect).			chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	AGCGGCATCCCGCTGCCTAGG	0.592000													13	27					0	0	1	0	0
CDHR5	53841	broad.mit.edu	37	11	617465	617465	+	Silent	SNP	C	C	T	rs139083373		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:617465C>T	ENST00000358353.3	-	16	2746	c.2424G>A	c.(2422-2424)gcG>gcA	p.A808A	CDHR5_ENST00000397542.2_Silent_p.A808A|CDHR5_ENST00000349570.7_Silent_p.A614A			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	808					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						CCAGGGTGGGCGCGTTGAGAA	0.701000													13	27					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89347321	89347321	+	Missense_Mutation	SNP	G	G	A	rs142527333	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:89347321G>A	ENST00000301030.4	-	9	6089	c.5629C>T	c.(5629-5631)Ccg>Tcg	p.P1877S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P1877S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1877	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCTGGAGACGGGGTGACAGTG	0.622000													17	24					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156816382	156816382	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:156816382C>T	ENST00000347377.6	+	29	3824	c.3393C>T	c.(3391-3393)agC>agT	p.S1131S	CYFIP2_ENST00000522463.1_Silent_p.S935S|CYFIP2_ENST00000377576.3_Silent_p.S1131S|CYFIP2_ENST00000541131.1_Silent_p.S1056S|CYFIP2_ENST00000521420.1_Silent_p.S1105S|CYFIP2_ENST00000435847.2_Silent_p.S830S|CYFIP2_ENST00000442283.2_3'UTR|CYFIP2_ENST00000318218.6_Silent_p.S1156S	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1156					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGCTGTGGAGCGCCATGCAGT	0.622000													13	27					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53668564	53668564	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53668564C>T	ENST00000600412.1	-	2	1099	c.984G>A	c.(982-984)caG>caA	p.Q328Q	ZNF665_ENST00000396424.3_Silent_p.Q393Q			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TATGGATGATCTGATGCTTAG	0.398000													10	46					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3832871	3832871	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3832871C>A	ENST00000262367.5	-	6	2196	c.1387G>T	c.(1387-1389)Ggg>Tgg	p.G463W	CREBBP_ENST00000382070.3_Missense_Mutation_p.G425W	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	463					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TTCTGTTGCCCTGTGCCAACA	0.493000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						16	35					7.07596e-05	7.26534e-05	1	1	0
FAM211B	388886	broad.mit.edu	37	22	24982100	24982100	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:24982100G>A	ENST00000318753.8	-	4	725	c.702C>T	c.(700-702)gaC>gaT	p.D234D	GGT1_ENST00000248923.4_Intron	NM_207644.2	NP_997527.2	Q2VPJ9	LRC6X_HUMAN	family with sequence similarity 211, member B	234																	ACTTGGTGGTGTCCTTGATGG	0.677000													15	102					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32151335	32151335	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32151335G>T	ENST00000373672.3	-	29	2437	c.1921C>A	c.(1921-1923)Ctt>Att	p.L641I	COL16A1_ENST00000373668.3_Missense_Mutation_p.L641I|COL16A1_ENST00000271069.6_Missense_Mutation_p.L640I	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	641	Nonhelical region 7 (NC7).				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CCATCCTGAAGGTTGGACAGG	0.632000													32	72					6.05902e-23	6.74593e-23	1	1	0
PCDHGA8	0	broad.mit.edu	37	5	140773156	140773156	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140773156C>T	ENST00000398604.2	+	1	776	c.776C>T	c.(775-777)aCg>aTg	p.T259M	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCCAGGCACGCGGCTGCTT	0.488000													27	69					0	0	1	0	0
CAB39L	81617	broad.mit.edu	37	13	49956951	49956951	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:49956951G>A	ENST00000355854.4	-	2	593	c.96C>T	c.(94-96)gaC>gaT	p.D32D	CAB39L_ENST00000409308.1_Silent_p.D32D|CAB39L_ENST00000476943.1_5'UTR|CAB39L_ENST00000410043.1_Silent_p.D32D|CAB39L_ENST00000347776.5_Silent_p.D32D	NM_030925.2	NP_112187.2	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	32					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding			breast(1)|endometrium(2)|large_intestine(4)|lung(3)|pancreas(1)|stomach(1)	12		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		CTGTCTTTTTGTCTTGCTTTT	0.318000													12	24					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96829259	96829259	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:96829259G>A	ENST00000359933.4	-	1	948	c.55C>T	c.(55-57)Cag>Tag	p.Q19*		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	19										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AGGTACCTCTGCAGGAGGTAC	0.642000													22	47					0	0	1	0	0
MED26	9441	broad.mit.edu	37	19	16687031	16687031	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16687031G>A	ENST00000263390.3	-	3	1872	c.1610C>T	c.(1609-1611)cCc>cTc	p.P537L	CTD-3222D19.2_ENST00000409035.1_Intron	NM_004831.3	NP_004822.2	O95402	MED26_HUMAN	mediator complex subunit 26	537					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	8						GAGGTCCGTGGGCGGGCTTTG	0.647000													25	21					0	0	1	0	0
RIC8A	60626	broad.mit.edu	37	11	214299	214299	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:214299C>T	ENST00000526104.1	+	10	2889	c.1545C>T	c.(1543-1545)tgC>tgT	p.C515C	RIC8A_ENST00000527696.1_Silent_p.C509C|RIC8A_ENST00000325207.5_Silent_p.C521C|RIC8A_ENST00000531541.1_3'UTR			Q9NPQ8	RIC8A_HUMAN	RIC8 guanine nucleotide exchange factor A	515						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)	13		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		ATGCCATGTGCGAGACTATGG	0.607000													6	13					0	0	1	0	0
HCAR1	27198	broad.mit.edu	37	12	123214176	123214176	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:123214176C>T	ENST00000432564.1	-	1	953	c.711G>A	c.(709-711)gtG>gtA	p.V237V	HCAR1_ENST00000436083.2_Silent_p.V237V|HCAR1_ENST00000356987.2_Silent_p.V237V	NM_032554.3	NP_115943.1	Q9BXC0	HCAR1_HUMAN	hydroxycarboxylic acid receptor 1	237					response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)	10						GTCTAGCAGACACGCTGGGCA	0.582000													8	38					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228401957	228401957	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228401957G>T	ENST00000570156.2	+	4	1415	c.1341G>T	c.(1339-1341)ccG>ccT	p.P447P	OBSCN_ENST00000284548.11_Silent_p.P447P|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000422127.1_Silent_p.P447P	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	447	Ig-like 5.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGGCGGTCCCGGTGGGCCCCG	0.701000													4	73					0.150653	0.151081	1	1	0
ZEB2	9839	broad.mit.edu	37	2	145147501	145147501	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:145147501G>T	ENST00000558170.2	-	10	4346	c.3162C>A	c.(3160-3162)ccC>ccA	p.P1054P	ZEB2_ENST00000409487.3_Silent_p.P1054P|ZEB2_ENST00000303660.4_Silent_p.P1054P|ZEB2_ENST00000539609.3_Silent_p.P1030P	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	1054						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		CACACTGATAGGGCTTCTCGC	0.512000													12	17					0.00010058	0.000103117	1	1	0
AP2B1	163	broad.mit.edu	37	17	33966626	33966626	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:33966626C>A	ENST00000262325.7	+	11	1837	c.1284C>A	c.(1282-1284)atC>atA	p.I428I	AP2B1_ENST00000545922.2_3'UTR|AP2B1_ENST00000537622.2_Silent_p.I428I|AP2B1_ENST00000589344.1_Silent_p.I428I|AP2B1_ENST00000312678.8_Silent_p.I428I|AP2B1_ENST00000592545.1_Silent_p.I390I|AP2B1_ENST00000538556.1_Silent_p.I371I	NM_001282.2	NP_001273.1	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1 subunit	428					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		ATGAAAGTATCATCGCCACTC	0.398000													24	47					3.01185e-09	3.19065e-09	1	1	0
HERC2	8924	broad.mit.edu	37	15	28502369	28502369	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28502369G>A	ENST00000261609.7	-	17	2463	c.2355C>T	c.(2353-2355)ggC>ggT	p.G785G		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	785					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GGACACGGAGGCCAATGGACC	0.512000													6	7					0	0	1	0	0
VDR	0	broad.mit.edu	37	12	48251320	48251320	+	Silent	SNP	G	G	A	rs140864473		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48251320G>A	ENST00000229022.3	-	6	710	c.429C>T	c.(427-429)taC>taT	p.Y143Y	VDR_ENST00000535672.1_Silent_p.Y111Y|VDR_ENST00000395324.2_Silent_p.Y143Y|VDR_ENST00000549336.1_Silent_p.Y143Y|VDR_ENST00000550325.1_Silent_p.Y193Y	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	143	Hinge.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	AGGTGGGGTCGTAGGTCTTAT	0.617000													14	16					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56381740	56381740	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56381740G>A	ENST00000268893.6	-	30	6224	c.5385C>T	c.(5383-5385)gtC>gtT	p.V1795V	BZRAP1_ENST00000355701.3_Intron|BZRAP1_ENST00000343736.4_Silent_p.V1855V	NM_024418.2	NP_077729.1	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1855	SH3 3.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCTAGCACTGGACTCTTCTCC	0.567000											OREG0024610	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	85					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18872438	18872438	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18872438C>T	ENST00000317977.6	+	6	930	c.359C>T	c.(358-360)aCg>aTg	p.T120M	FAM83G_ENST00000388995.6_3'UTR|SLC5A10_ENST00000395645.3_Missense_Mutation_p.T176M|SLC5A10_ENST00000417251.2_Missense_Mutation_p.T176M|SLC5A10_ENST00000395642.1_Missense_Mutation_p.T120M|SLC5A10_ENST00000395643.2_Missense_Mutation_p.T176M|SLC5A10_ENST00000395647.2_Missense_Mutation_p.T176M			A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	176					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						ACCATCCTCACGCTCGGCATC	0.627000													9	19					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9025600	9025600	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9025600G>A	ENST00000397910.4	-	15	37057	c.36854C>T	c.(36853-36855)aCc>aTc	p.T12285I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12287	SEA 2.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCTGAGCAAGGTCAATCTGCA	0.517000													29	46					0	0	1	0	0
MIR373	0	broad.mit.edu	37	19	54291980	54291980	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54291980C>T	ENST00000362273.1	+	0	22					NR_029866.1																						AATGGGGGCGCTTTCCTTTTT	0.527000													4	8					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30724641	30724641	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30724641C>T	ENST00000262518.4	+	15	2628	c.2243C>T	c.(2242-2244)gCg>gTg	p.A748V	SRCAP_ENST00000344771.4_Missense_Mutation_p.A748V|SRCAP_ENST00000395059.2_Missense_Mutation_p.A748V	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	748	Helicase ATP-binding.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CTGGATGAGGCGCAGAACATC	0.522000													20	36					0	0	1	0	0
BASP1	10409	broad.mit.edu	37	5	17275931	17275931	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:17275931C>T	ENST00000322611.3	+	2	866	c.606C>T	c.(604-606)ccC>ccT	p.P202P		NM_001271606.1|NM_006317.3	NP_001258535.1|NP_006308.3	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein 1	202					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding			endometrium(1)|lung(8)	9						CCCAGGGCCCCGCAGCCTCTG	0.617000													12	18					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41410696	41410696	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:41410696A>G	ENST00000551295.2	+	19	2514	c.2397A>G	c.(2395-2397)gcA>gcG	p.A799A	CNTN1_ENST00000347616.1_Silent_p.A799A|CNTN1_ENST00000348761.2_Silent_p.A788A|CNTN1_ENST00000550305.1_3'UTR	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	799	Fibronectin type-III 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GCCTAGTAGCAGTCATTAATT	0.418000													11	33					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6167158	6167158	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6167158C>T	ENST00000261405.5	-	14	1840	c.1586G>A	c.(1585-1587)gGc>gAc	p.G529D		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	529	VWFD 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GCCCTGGTTGCCATTGTAATT	0.667000													28	43					0	0	1	0	0
CHD6	0	broad.mit.edu	37	20	40076586	40076586	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:40076586A>G	ENST00000373233.3	-	24	3886	c.3709T>C	c.(3709-3711)Tac>Cac	p.Y1237H	CHD6_ENST00000309279.7_Missense_Mutation_p.Y720H	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1237					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TTTAGGTAGTACAGCATCCGG	0.398000													23	122					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126707689	126707689	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:126707689G>A	ENST00000251772.4	+	1	253	c.184G>A	c.(184-186)Gtc>Atc	p.V62I	PLXNA1_ENST00000393409.2_Missense_Mutation_p.V85I			Q9UIW2	PLXA1_HUMAN	plexin A1	85	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		GCGGGCCCACGTCACGGGCCC	0.632000													18	24					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105830199	105830199	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:105830199C>T	ENST00000353479.5	-	9	882	c.592G>A	c.(592-594)Gcg>Acg	p.A198T	COL17A1_ENST00000369733.3_Missense_Mutation_p.A198T|COL17A1_ENST00000393211.3_Missense_Mutation_p.A198T	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	198	Necessary for interaction with DST and for the recruitment of DST to hemidesmosome.|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TGGGAGCTCGCTGTCACAATT	0.562000													21	22					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156482274	156482274	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:156482274C>T	ENST00000339252.3	-	2	849	c.317G>A	c.(316-318)cGt>cAt	p.R106H	HAVCR1_ENST00000544197.1_Missense_Mutation_p.R106H|HAVCR1_ENST00000523175.1_Missense_Mutation_p.R106H|HAVCR1_ENST00000425854.1_Missense_Mutation_p.R106H|HAVCR1_ENST00000522693.1_Missense_Mutation_p.R106H	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	106	Ig-like V-type.				interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGCTCAACACGGCAACAATA	0.418000													32	73					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50222881	50222881	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50222881G>A	ENST00000002829.3	+	14	1946	c.1462G>A	c.(1462-1464)Ggg>Agg	p.G488R	SEMA3F_ENST00000434342.1_Missense_Mutation_p.G457R|SEMA3F_ENST00000413852.1_Missense_Mutation_p.G389R	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	488	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity	p.G488W(1)		central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		TCCAGACCGCGGGACAGTGCA	0.657000													4	10					0	0	1	0	0
CLN8	2055	broad.mit.edu	37	8	1728597	1728597	+	Missense_Mutation	SNP	C	C	T	rs138821993	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:1728597C>T	ENST00000331222.4	+	3	972	c.725C>T	c.(724-726)aCg>aTg	p.T242M	CLN8_ENST00000523237.1_3'UTR	NM_018941.3	NP_061764.2	Q9UBY8	CLN8_HUMAN	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)	242	TLC.				cell death|ceramide biosynthetic process|cholesterol metabolic process|lipid transport|negative regulation of proteolysis|phospholipid metabolic process	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.67e-05)|READ - Rectum adenocarcinoma(644;0.0913)		GCTCTGCTTACGCTAATCATT	0.522000													44	62					0	0	1	0	0
ENPP5	59084	broad.mit.edu	37	6	46135419	46135419	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:46135419C>T	ENST00000371383.2	-	3	841	c.581G>A	c.(580-582)gGc>gAc	p.G194D	ENPP5_ENST00000230565.3_Missense_Mutation_p.G194D			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	194						extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						CAAATGGTGGCCCATGTCATC	0.413000													26	43					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32933082	32933082	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:32933082C>T	ENST00000383763.4	+	4	2449	c.2386C>T	c.(2386-2388)Cgc>Tgc	p.R796C		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	796					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GCAGTTCCTGCGCCCACAAGG	0.592000													25	45					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102290602	102290602	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:102290602C>T	ENST00000370103.4	-	4	785	c.572G>A	c.(571-573)cGt>cAt	p.R191H	OLFM3_ENST00000536598.1_Missense_Mutation_p.R116H|OLFM3_ENST00000359814.3_Missense_Mutation_p.R211H|OLFM3_ENST00000338858.5_Missense_Mutation_p.R211H|OLFM3_ENST00000462354.1_5'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	211						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CATGCAGTCACGAAGTCTTGT	0.373000													4	38					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73834034	73834034	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:73834034G>A	ENST00000334126.7	-	8	1590	c.1365_splice	c.e8+1	p.P455_splice	C2CD3_ENST00000313663.7_Splice_Site_p.P455_splice			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	455						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					GTGACTTACAGGTGCTGTATA	0.398000													22	42					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87242323	87242323	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:87242323T>C	ENST00000297524.3	-	1	287	c.184A>G	c.(184-186)Aca>Gca	p.T62A	SLC7A13_ENST00000520624.1_Intron|SLC7A13_ENST00000419776.2_Missense_Mutation_p.T62A	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	62						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						AGAGTTGATGTCATGGCCAGT	0.473000													13	46					0	0	1	0	0
COL10A1	1300	broad.mit.edu	37	6	116442996	116442996	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:116442996C>A	ENST00000327673.4	-	2	690	c.283G>T	c.(283-285)Ggg>Tgg	p.G95W	AL121963.1_ENST00000430695.1_Missense_Mutation_p.P126H|COL10A1_ENST00000243222.4_Missense_Mutation_p.G95W|NT5DC1_ENST00000319550.4_Intron			Q03692	COAA1_HUMAN	collagen, type X, alpha 1	95	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)|endometrium(2)|lung(6)|skin(3)|upper_aerodigestive_tract(1)	13		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		CCTGGCAACCCTGGCTCTCCT	0.602000													23	27					2.00529e-23	2.23482e-23	1	1	0
CLPTM1L	81037	broad.mit.edu	37	5	1321902	1321902	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1321902G>A	ENST00000320895.5	-	14	1605	c.1348C>T	c.(1348-1350)Ccc>Tcc	p.P450S	CLPTM1L_ENST00000507807.1_Missense_Mutation_p.P281S|CLPTM1L_ENST00000320927.6_Missense_Mutation_p.P414S|CLPTM1L_ENST00000506641.1_5'UTR	NM_030782.3	NP_110409.2	Q96KA5	CLP1L_HUMAN	CLPTM1-like	450					apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		AAGAGCTGGGGCAGCATGAAG	0.627000													13	14					0	0	1	0	0
MTF1	4520	broad.mit.edu	37	1	38289411	38289411	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:38289411G>A	ENST00000373036.4	-	8	1282	c.1142C>T	c.(1141-1143)aCg>aTg	p.T381M		NM_005955.2	NP_005946.2	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	381						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			endometrium(3)|kidney(5)|large_intestine(6)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)	31	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CTGAATTGCCGTATCATCTGA	0.453000													9	16					0	0	1	0	0
DIO2	1734	broad.mit.edu	37	14	80677658	80677658	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:80677658C>T	ENST00000557010.1	-	3	543	c.158G>A	c.(157-159)cGc>cAc	p.R53H	DIO2_ENST00000422005.3_Missense_Mutation_p.R53H|DIO2_ENST00000555750.1_Missense_Mutation_p.R53H|DIO2_ENST00000438257.4_Missense_Mutation_p.R53H|DIO2_ENST00000557125.1_Intron	NM_000793.5|NM_001242502.1|NM_001242503.1	NP_000784.2|NP_001229431.1|NP_001229432.1	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	53					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		GGTCAGCATGCGCCGCCACTC	0.587000													11	9					0	0	1	0	0
KIAA0355	9710	broad.mit.edu	37	19	34791425	34791425	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:34791425G>A	ENST00000299505.6	+	2	920	c.47G>A	c.(46-48)cGc>cAc	p.R16H		NM_014686.3	NP_055501.2	O15063	K0355_HUMAN	KIAA0355	16										breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					TACAAGCGGCGCTTCCTGCTT	0.597000													14	22					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53998224	53998224	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:53998224C>T	ENST00000396328.1	-	10	1241	c.1002G>A	c.(1000-1002)gaG>gaA	p.E334E	WDR72_ENST00000557913.1_Silent_p.E331E|WDR72_ENST00000360509.5_Silent_p.E334E|WDR72_ENST00000559418.1_Silent_p.E344E	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	334										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TGTAAAAAGGCTCTTTCCTTT	0.403000													10	40					0	0	1	0	0
RNF212	285498	broad.mit.edu	37	4	1107206	1107206	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1107206C>A	ENST00000382968.5	-	1	144	c.47G>T	c.(46-48)aGg>aTg	p.R16M	RNF212_ENST00000333673.5_Missense_Mutation_p.R16M|RNF212_ENST00000433731.2_Missense_Mutation_p.R16M|RNF212_ENST00000505730.1_5'UTR	NM_001131034.3|NM_194439.4	NP_001124506.1|NP_919420.1	Q495C1	RN212_HUMAN	ring finger protein 212	16							zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(23;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (64;0.151)		GCACGACGTCCTGTGGGGCGG	0.692000													13	10					4.14922e-12	4.48033e-12	1	1	0
TRIM33	51592	broad.mit.edu	37	1	114968110	114968110	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:114968110C>T	ENST00000358465.2	-	9	1739	c.1656G>A	c.(1654-1656)caG>caA	p.Q552Q	TRIM33_ENST00000369543.2_Silent_p.Q552Q|TRIM33_ENST00000450349.2_Silent_p.Q160Q	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	552					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTCTAGGATGCTGTTGTGTTG	0.413000			T	RET	papillary thyroid								21	159					0	0	1	0	0
C8orf58	541565	broad.mit.edu	37	8	22458719	22458719	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22458719G>A	ENST00000409586.3	+	2	485	c.365G>A	c.(364-366)cGc>cAc	p.R122H	C8orf58_ENST00000453427.2_3'UTR|C8orf58_ENST00000289989.5_Missense_Mutation_p.R122H	NM_001013842.2|NM_001198827.1|NM_173686.2	NP_001013864.1|NP_001185756.1|NP_775957.2	Q8NAV2	CH058_HUMAN	chromosome 8 open reading frame 58	122										endometrium(1)|lung(1)|ovary(1)|skin(1)	4		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GAGCGGTCCCGCCGGCTCCCA	0.657000													6	8					0	0	1	0	0
KLHL32	114792	broad.mit.edu	37	6	97587107	97587107	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:97587107C>T	ENST00000369261.4	+	11	2175	c.1812C>T	c.(1810-1812)tgC>tgT	p.C604C	KLHL32_ENST00000539200.1_Silent_p.C535C|KLHL32_ENST00000544166.1_Silent_p.C160C|KLHL32_ENST00000536676.1_Silent_p.C568C	NM_052904.3	NP_443136.2	Q96NJ5	KLH32_HUMAN	kelch-like family member 32	604										breast(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(13)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		ATTTTACATGCCCTAACCTTC	0.448000													31	45					0	0	1	0	0
FOXRED1	55572	broad.mit.edu	37	11	126145710	126145710	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:126145710G>A	ENST00000263578.5	+	7	829	c.755G>A	c.(754-756)cGc>cAc	p.R252H	FOXRED1_ENST00000442061.2_Missense_Mutation_p.R82H|FOXRED1_ENST00000534011.1_3'UTR|FOXRED1_ENST00000532125.1_Missense_Mutation_p.R238H	NM_017547.3	NP_060017.1	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing 1	252						integral to membrane|mitochondrion	oxidoreductase activity|protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	15	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		TCATCTCAACGCATGTTGACC	0.428000													18	37					0	0	1	0	0
GPAT2	150763	broad.mit.edu	37	2	96690302	96690302	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:96690302C>T	ENST00000434632.1	-	16	2001	c.1542G>A	c.(1540-1542)gcG>gcA	p.A514A	GPAT2_ENST00000377137.3_Silent_p.A514A|GPAT2_ENST00000453542.1_Silent_p.A443A|GPAT2_ENST00000359548.4_Silent_p.A514A			Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2, mitochondrial	514					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(5)|skin(3)	16						GGGCCACGTGCGCCCGCAGCA	0.647000													6	32					0	0	1	0	0
NSUN2	54888	broad.mit.edu	37	5	6605395	6605395	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:6605395C>T	ENST00000264670.6	-	15	2039	c.1728G>A	c.(1726-1728)gaG>gaA	p.E576E	NSUN2_ENST00000539938.1_Silent_p.E340E|NSUN2_ENST00000506139.1_Silent_p.E541E	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	576						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						CCTTCATCTTCTCACTGTTAT	0.498000													35	62					0	0	1	0	0
FOXL1	2300	broad.mit.edu	37	16	86612535	86612535	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:86612535G>T	ENST00000320241.3	+	1	421	c.206G>T	c.(205-207)aGg>aTg	p.R69M		NM_005250.2	NP_005241.1	Q12952	FOXL1_HUMAN	forkhead box L1	69					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(2)|prostate(3)|skin(1)|urinary_tract(1)	15						CCCGAGCAGAGGGTCACGCTC	0.647000													24	37					5.35356e-11	5.74024e-11	1	1	0
KDM5A	5927	broad.mit.edu	37	12	464374	464374	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:464374C>T	ENST00000399788.2	-	7	1182	c.820G>A	c.(820-822)Gca>Aca	p.A274T	KDM5A_ENST00000382815.4_Missense_Mutation_p.A274T	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	274					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						ATGTTAAATGCGTCTGACCTG	0.373000			T	NUP98	AML								25	46					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35987305	35987305	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:35987305G>A	ENST00000490799.1	-	2	533	c.180C>T	c.(178-180)gtC>gtT	p.V60V	SLC26A8_ENST00000394602.2_Silent_p.V60V|SLC26A8_ENST00000355574.2_Silent_p.V60V	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	60					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						ACCGGCACTGGACGTGGTGTC	0.512000													7	15					0	0	1	0	0
CAMK1D	57118	broad.mit.edu	37	10	12708804	12708804	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:12708804G>A	ENST00000378847.3	+	3	631	c.294G>A	c.(292-294)atG>atA	p.M98I	CAMK1D_ENST00000487696.1_3'UTR|CAMK1D_ENST00000378845.1_Missense_Mutation_p.M98I	NM_153498.2	NP_705718.1	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	98	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)	16				GBM - Glioblastoma multiforme(1;3.16e-05)		ACTTGGTCATGCAGCTGTAAG	0.388000													4	93					0	0	1	0	0
CEBPZ	10153	broad.mit.edu	37	2	37454884	37454884	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:37454884G>A	ENST00000234170.5	-	2	1597	c.1452C>T	c.(1450-1452)agC>agT	p.S484S		NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	484					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				TTAAAAGGGCGCTAAGCATTT	0.368000													26	45					0	0	1	0	0
SIRT6	51548	broad.mit.edu	37	19	4174911	4174911	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4174911G>A	ENST00000594279.1	-	8	733	c.515C>T	c.(514-516)aCg>aTg	p.T172M	SIRT6_ENST00000381935.3_Silent_p.Y185Y|SIRT6_ENST00000337491.2_Silent_p.Y257Y|SIRT6_ENST00000305232.6_Silent_p.Y230Y|SIRT6_ENST00000601488.1_Missense_Mutation_p.T183M			Q8N6T7	SIRT6_HUMAN	sirtuin 6	0	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation	nuclear telomeric heterochromatin|nucleoplasm	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|protein binding|zinc ion binding			central_nervous_system(1)|kidney(1)|lung(4)|ovary(1)|skin(1)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.023)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCGTCAACGTAGCCATGGA	0.711000													8	30					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23530642	23530642	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23530642G>A	ENST00000262710.1	-	17	3790	c.3463C>T	c.(3463-3465)Cgg>Tgg	p.R1155W	ACIN1_ENST00000338631.6_Missense_Mutation_p.R428W|ACIN1_ENST00000397341.3_Missense_Mutation_p.R397W|ACIN1_ENST00000557515.1_Missense_Mutation_p.R396W|ACIN1_ENST00000605057.1_Missense_Mutation_p.R1097W|ACIN1_ENST00000457657.1_Missense_Mutation_p.R1115W|ACIN1_ENST00000357481.2_Missense_Mutation_p.R397W|ACIN1_ENST00000555053.1_Missense_Mutation_p.R1142W	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1155	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding	p.R1155W(1)		breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CGCTCCCGCCGCTCCATTTCC	0.677000													6	55					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121409891	121409891	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:121409891C>A	ENST00000393667.3	-	14	8430	c.8320G>T	c.(8320-8322)Gca>Tca	p.A2774S	GOLGB1_ENST00000340645.5_Missense_Mutation_p.A2769S	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	2769					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TTCAACTGTGCCAATTCCTTC	0.408000													39	56					6.29468e-14	6.85409e-14	1	1	0
CDC23	8697	broad.mit.edu	37	5	137548685	137548685	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137548685T>C	ENST00000394886.2	-	2	259	c.229A>G	c.(229-231)Aca>Gca	p.T77A	CDC23_ENST00000394884.3_Missense_Mutation_p.T77A|CDC23_ENST00000505120.1_Missense_Mutation_p.T77A	NM_004661.3	NP_004652.2	Q9UJX2	CDC23_HUMAN	cell division cycle 23	77					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(6)|prostate(2)|skin(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTTACCTCTGTAATAGGCGGA	0.572000													11	33					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	72998426	72998426	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:72998426C>T	ENST00000322038.5	+	2	1513	c.929C>T	c.(928-930)gCg>gTg	p.A310V	TSHZ1_ENST00000580243.1_Missense_Mutation_p.A355V	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	355						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		AAAAAGCGGGCGCTTCAGGAC	0.602000													8	16					0	0	1	0	0
SLC22A5	6584	broad.mit.edu	37	5	131724688	131724688	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:131724688G>A	ENST00000245407.3	+	6	1248	c.1027G>A	c.(1027-1029)Gtc>Atc	p.V343I	SLC22A5_ENST00000435065.2_Missense_Mutation_p.V367I|SLC22A5_ENST00000479605.1_3'UTR	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	343					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	TATCCGGATGGTCACCATCAT	0.463000											OREG0003454	type=REGULATORY REGION|Gene=SLC22A5|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	14	28					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32363946	32363946	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32363946A>G	ENST00000454136.3	-	5	952	c.948T>C	c.(946-948)agT>agC	p.S316S	BTNL2_ENST00000429232.2_Silent_p.S223S|BTNL2_ENST00000374993.1_Silent_p.S316S|BTNL2_ENST00000374995.3_Silent_p.S222S|BTNL2_ENST00000544175.1_Silent_p.S39S|BTNL2_ENST00000540315.1_Silent_p.S106S|BTNL2_ENST00000414363.1_Silent_p.S106S			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	316	Ig-like V-type 3.					integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						CAATGGCGTCACTCACCAGTA	0.552000													14	23					0	0	1	0	0
IMMT	10989	broad.mit.edu	37	2	86406606	86406606	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:86406606C>T	ENST00000410111.3	-	3	646	c.259G>A	c.(259-261)Gag>Aag	p.E87K	IMMT_ENST00000449247.2_Missense_Mutation_p.E87K|IMMT_ENST00000409051.2_Missense_Mutation_p.E87K|IMMT_ENST00000254636.5_5'UTR|IMMT_ENST00000442664.2_Missense_Mutation_p.E87K	NM_001100169.1|NM_001100170.1|NM_006839.2	NP_001093639.1|NP_001093640.1|NP_006830.2	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial	87						integral to mitochondrial inner membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						AGAACCATCTCGAAGAGTTTG	0.383000													5	14					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143633212	143633212	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:143633212A>G	ENST00000408955.2	+	1	954	c.887A>G	c.(886-888)gAg>gGg	p.E296G		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					AGGAATAAAGAGGTGAAGGGG	0.433000													21	34					0	0	1	0	0
PRR5L	79899	broad.mit.edu	37	11	36467868	36467868	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:36467868C>T	ENST00000378867.3	+	8	818	c.463C>T	c.(463-465)Cgc>Tgc	p.R155C	PRR5L_ENST00000527487.1_Missense_Mutation_p.R155C|PRR5L_ENST00000311599.5_Intron|PRR5L_ENST00000389693.3_Intron|PRR5L_ENST00000530639.1_Missense_Mutation_p.R155C	NM_024841.4	NP_079117.3	Q6MZQ0	PRR5L_HUMAN	proline rich 5 like	155										breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)	19						GCTGACTATCCGCCAGATCTC	0.597000													7	17					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147131197	147131197	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:147131197C>T	ENST00000282928.4	+	3	1932	c.1203C>T	c.(1201-1203)taC>taT	p.Y401Y		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	401	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						GCTCTGGCTACGAATCCTCCA	0.617000													26	29					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90425472	90425472	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:90425472G>A	ENST00000369393.3	-	45	6875	c.6760C>T	c.(6760-6762)Cgt>Tgt	p.R2254C	MDN1_ENST00000428876.1_Missense_Mutation_p.R2254C			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	2254					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GCATTCAAACGATCCAACACT	0.478000													29	41					0	0	1	0	0
OLFML2B	25903	broad.mit.edu	37	1	161954013	161954013	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161954013C>T	ENST00000294794.3	-	8	2128	c.1705G>A	c.(1705-1707)Gtg>Atg	p.V569M	OLFML2B_ENST00000367940.2_Missense_Mutation_p.V570M|OLFML2B_ENST00000367938.1_Missense_Mutation_p.V52M	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	569	Olfactomedin-like.									breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TTGTATACCACGTGGCCTGTG	0.582000													18	29					0	0	1	0	0
DDX58	23586	broad.mit.edu	37	9	32491392	32491392	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:32491392G>A	ENST00000379882.1	-	4	620	c.463C>T	c.(463-465)Ctt>Ttt	p.L155F	DDX58_ENST00000379868.1_5'UTR|DDX58_ENST00000542096.1_Missense_Mutation_p.L129F|DDX58_ENST00000379883.2_Missense_Mutation_p.L200F|DDX58_ENST00000545044.1_5'UTR			O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	200	CARD 2.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		TTATCCTCAAGATCTTCTGTT	0.348000													8	21					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	404916	404916	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:404916C>T	ENST00000399788.2	-	26	4640	c.4278G>A	c.(4276-4278)gtG>gtA	p.V1426V	KDM5A_ENST00000382815.4_Silent_p.V1426V	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1426					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						AACTTCGGGGCACCAAAGGGC	0.438000			T	NUP98	AML								45	60					0	0	1	0	0
ADCK4	79934	broad.mit.edu	37	19	41209498	41209498	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41209498G>A	ENST00000324464.3	-	9	1048	c.747C>T	c.(745-747)agC>agT	p.S249S	ADCK4_ENST00000450541.1_Silent_p.S208S|ADCK4_ENST00000243583.6_Silent_p.S208S	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	249	Protein kinase.					integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			TCTGGACATCGCTCTGAATGC	0.642000													9	13					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48173142	48173142	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:48173142C>T	ENST00000311303.3	-	5	1108	c.763G>A	c.(763-765)Gcc>Acc	p.A255T	ABCC12_ENST00000448542.1_Missense_Mutation_p.A255T|ABCC12_ENST00000416054.1_Missense_Mutation_p.A255T	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	255	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				ATGAAAAAGGCGTACGCCGCA	0.473000													28	35					0	0	1	0	0
PRIM2	5558	broad.mit.edu	37	6	57246843	57246843	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:57246843T>C	ENST00000607273.1	+	7	657	c.570T>C	c.(568-570)gaT>gaC	p.D190D	PRIM2_ENST00000389488.2_3'UTR	NM_000947.2	NP_000938.2	P49643	PRI2_HUMAN	primase, DNA, polypeptide 2 (58kDa)	190					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(34)|prostate(6)|stomach(4)|upper_aerodigestive_tract(1)	59				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CTTTTGCTGATGCTCTGGATT	0.363000													5	26					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201356061	201356061	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:201356061C>T	ENST00000391967.2	-	3	729	c.428G>A	c.(427-429)cGc>cAc	p.R143H	LAD1_ENST00000367313.3_Missense_Mutation_p.R157H	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	143						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						CAGTCTCCGGCGAGGTGGGAT	0.617000													22	56					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11905843	11905843	+	Missense_Mutation	SNP	G	G	A	rs140179571		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:11905843G>A	ENST00000256720.2	+	2	269	c.176G>A	c.(175-177)cGc>cAc	p.R59H	LPIN1_ENST00000396098.1_Missense_Mutation_p.R65H|LPIN1_ENST00000449576.2_Missense_Mutation_p.R108H|LPIN1_ENST00000425416.2_Missense_Mutation_p.R65H|LPIN1_ENST00000396099.1_Missense_Mutation_p.R65H	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	59	N-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity	p.R59H(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		GGGGTCCTGCGCTCCCGAGAG	0.572000													27	24					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62285540	62285540	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62285540G>A	ENST00000378024.4	-	5	16623	c.16349C>T	c.(16348-16350)cCg>cTg	p.P5450L	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5450					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GTCCACATTCGGTGCTGAAAT	0.562000													6	70					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870105	51870105	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:51870105C>T	ENST00000371497.5	+	2	995	c.108C>T	c.(106-108)agC>agT	p.S36S	TSHZ2_ENST00000329613.6_Silent_p.S33S|TSHZ2_ENST00000603338.2_Silent_p.S33S	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	36					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.S36S(1)		NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			aggaggaCAGCGGTTCAGTAG	0.527000													8	10					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3850872	3850872	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3850872G>A	ENST00000309890.7	-	8	1058	c.908C>T	c.(907-909)gCg>gTg	p.A303V	ATP2A3_ENST00000397043.3_Missense_Mutation_p.A303V|ATP2A3_ENST00000352011.3_Missense_Mutation_p.A303V|ATP2A3_ENST00000359983.3_Missense_Mutation_p.A303V|ATP2A3_ENST00000397041.3_Missense_Mutation_p.A303V|ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000397035.3_Missense_Mutation_p.A303V	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	303					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GGCCGCCACCGCCAGGGCCAC	0.682000													18	19					0	0	1	0	0
ZNF496	84838	broad.mit.edu	37	1	247464531	247464531	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247464531T>C	ENST00000294753.4	-	9	1518	c.1054A>G	c.(1054-1056)Acc>Gcc	p.T352A	ZNF496_ENST00000366498.2_Missense_Mutation_p.T388A|ZNF496_ENST00000462139.1_5'UTR	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	352					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			ATCTCGATGGTCACTTCTTCA	0.612000													15	26					0	0	1	0	0
PPP1R36	145376	broad.mit.edu	37	14	65031490	65031490	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:65031490C>T	ENST00000298705.1	+	4	300	c.204C>T	c.(202-204)gtC>gtT	p.V68V	RP11-973N13.3_ENST00000556634.1_RNA|RP11-973N13.3_ENST00000554454.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	68																	CAGCAGAAGTCAAGGAAAAAG	0.398000													40	68					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181706764	181706764	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:181706764G>A	ENST00000526775.1	+	22	3634	c.3469G>A	c.(3469-3471)Gtc>Atc	p.V1157I	CACNA1E_ENST00000367570.1_Missense_Mutation_p.V1176I|CACNA1E_ENST00000360108.3_Missense_Mutation_p.V1157I|CACNA1E_ENST00000367567.4_Missense_Mutation_p.V783I|CACNA1E_ENST00000367573.2_Missense_Mutation_p.V1176I|CACNA1E_ENST00000357570.5_Missense_Mutation_p.V1127I|CACNA1E_ENST00000358338.5_Missense_Mutation_p.V1108I	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1176					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AGAGGACCCCGTCCTGACCAA	0.617000													32	40					0	0	1	0	0
KIAA1967	0	broad.mit.edu	37	8	22472943	22472943	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22472943G>A	ENST00000308511.4	+	12	1460	c.1211G>A	c.(1210-1212)cGc>cAc	p.R404H	KIAA1967_ENST00000389279.3_Missense_Mutation_p.R404H|RP11-582J16.5_ENST00000521025.1_RNA|KIAA1967_ENST00000520861.1_Missense_Mutation_p.R79H			Q8N163	K1967_HUMAN		404					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|skin(5)	25		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		TGCAGGTGGCGCTTTGCCGAG	0.567000													29	68					0	0	1	0	0
ZC3H3	23144	broad.mit.edu	37	8	144620919	144620919	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144620919G>A	ENST00000262577.5	-	2	649	c.618C>T	c.(616-618)ggC>ggT	p.G206G		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	206					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CGCCCACACTGCCCACTGACT	0.642000													5	13					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212799339	212799339	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:212799339G>T	ENST00000294829.3	+	1	1551	c.1120G>T	c.(1120-1122)Gga>Tga	p.G374*	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	374	Ala-rich.									breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		GGCCATTGCAGGAGTAGTACT	0.612000													8	22					5.18039e-06	5.37127e-06	1	1	0
CHRNA10	57053	broad.mit.edu	37	11	3687407	3687407	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3687407C>T	ENST00000250699.2	-	5	1354	c.1283G>A	c.(1282-1284)cGc>cAc	p.R428H	CHRNA10_ENST00000534359.1_3'UTR	NM_020402.2	NP_065135.2	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10 (neuronal)	428					elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			breast(1)|endometrium(2)|lung(3)|ovary(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	CAGGAAGAAGCGGTCCATCAC	0.622000													8	32					0	0	1	0	0
SIRT1	23411	broad.mit.edu	37	10	69676052	69676052	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:69676052G>A	ENST00000212015.6	+	9	1999	c.1946G>A	c.(1945-1947)cGt>cAt	p.R649H	SIRT1_ENST00000432464.1_Missense_Mutation_p.R354H|SIRT1_ENST00000406900.1_Missense_Mutation_p.R346H|SIRT1_ENST00000403579.1_Missense_Mutation_p.R346H	NM_012238.4	NP_036370.2	Q96EB6	SIRT1_HUMAN	sirtuin 1	649					apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	14						CCACCAAATCGTTACATTTTC	0.393000													42	58					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77415342	77415342	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:77415342C>T	ENST00000451710.3	-	17	2303	c.2066G>A	c.(2065-2067)cGc>cAc	p.R689H	TRPM6_ENST00000360774.1_Missense_Mutation_p.R689H|TRPM6_ENST00000361255.3_Missense_Mutation_p.R684H|TRPM6_ENST00000376864.4_Missense_Mutation_p.R689H|TRPM6_ENST00000449912.2_Missense_Mutation_p.R684H|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000376871.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	689					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CATGGCCATGCGCTCATTCTG	0.512000													32	35					0	0	1	0	0
PARP10	84875	broad.mit.edu	37	8	145051962	145051962	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145051962C>T	ENST00000313028.7	-	11	2862	c.2768G>A	c.(2767-2769)cGc>cAc	p.R923H	PARP10_ENST00000525773.1_Missense_Mutation_p.R935H|PARP10_ENST00000524918.1_Missense_Mutation_p.R914H	NM_032789.3	NP_116178.2	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	923	PARP catalytic.					Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(2)	27	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CAGGGAGGCGCGCCTGGCGAA	0.716000													5	7					0	0	1	0	0
RCE1	9986	broad.mit.edu	37	11	66613420	66613420	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66613420C>T	ENST00000309657.3	+	8	888	c.844C>T	c.(844-846)Cgg>Tgg	p.R282W	RCE1_ENST00000525356.1_Missense_Mutation_p.R159W|RCE1_ENST00000524506.1_Missense_Mutation_p.R261W	NM_001032279.1|NM_005133.2	NP_001027450.1|NP_005124.1	Q9Y256	FACE2_HUMAN	Ras converting CAAX endopeptidase 1	282					proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			breast(2)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						CCCACAGAGGCGGCCCCTGCT	0.612000													6	88					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610366	47610366	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47610366C>T	ENST00000371891.3	+	8	1073	c.1042C>T	c.(1042-1044)Cgg>Tgg	p.R348W	CYP4A22_ENST00000485117.1_Intron|CYP4A22_ENST00000371890.3_Intron|CYP4A22_ENST00000294337.3_Missense_Mutation_p.R348W|CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	348						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GGAGAGGTGCCGGGAGGAGAT	0.612000													12	28					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115231344	115231344	+	Missense_Mutation	SNP	C	C	T	rs140601541		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:115231344C>T	ENST00000369538.3	-	2	187	c.140G>A	c.(139-141)cGc>cAc	p.R47H	AMPD1_ENST00000520113.2_Missense_Mutation_p.R51H|AMPD1_ENST00000353928.6_Missense_Mutation_p.R18H	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	18					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding	p.R18H(1)		NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	AGCAAAGTTGCGCATTGCATC	0.418000													25	63					0	0	1	0	0
CRLF1	9244	broad.mit.edu	37	19	18709605	18709605	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18709605G>A	ENST00000392386.3	-	3	697	c.504C>T	c.(502-504)aaC>aaT	p.N168N		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	168	Fibronectin type-III 1.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						TGAGGGAGTAGTTGGTGTGGA	0.602000													8	17					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6043354	6043354	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:6043354C>T	ENST00000265849.7	-	4	425	c.320G>A	c.(319-321)cGg>cAg	p.R107Q	PMS2_ENST00000441476.2_Intron|PMS2_ENST00000469652.1_Intron|PMS2_ENST00000382321.4_Missense_Mutation_p.R107Q|PMS2_ENST00000406569.3_Missense_Mutation_p.R107Q	NM_000535.5	NP_000526.1	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	107					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		AGCTTCCCCCCGAAAGCCAAA	0.408000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				22	35					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37746200	37746200	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:37746200G>A	ENST00000539465.1	+	16	4764	c.4171G>A	c.(4171-4173)Gca>Aca	p.A1391T	RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Missense_Mutation_p.A1391T			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1391						cytoskeleton|cytosol|plasma membrane		p.A1391T(1)		NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CTGCACCACCGCACCCCTGTC	0.662000													31	6					0	0	1	0	0
RFC1	5981	broad.mit.edu	37	4	39318570	39318570	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:39318570C>T	ENST00000381897.1	-	10	1301	c.1168G>A	c.(1168-1170)Ggt>Agt	p.G390S	RFC1_ENST00000349703.2_Missense_Mutation_p.G390S	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	390					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						GCCTTGGGACCTTCTCGATTT	0.443000													23	29					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152515628	152515628	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:152515628T>C	ENST00000427231.2	-	47	6228	c.6026A>G	c.(6025-6027)gAt>gGt	p.D2009G	NEB_ENST00000172853.10_Missense_Mutation_p.D2009G|NEB_ENST00000409198.1_Missense_Mutation_p.D2009G|NEB_ENST00000604864.1_Missense_Mutation_p.D2009G|NEB_ENST00000603639.1_Missense_Mutation_p.D2009G|NEB_ENST00000397345.3_Missense_Mutation_p.D2009G	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2009					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTGGGGGATATCAGGCATGAT	0.373000													65	97					0	0	1	0	0
MAD1L1	8379	broad.mit.edu	37	7	1937867	1937867	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:1937867G>A	ENST00000406869.1	-	18	2524	c.1967C>T	c.(1966-1968)gCc>gTc	p.A656V	MAD1L1_ENST00000265854.7_Missense_Mutation_p.A656V|MAD1L1_ENST00000402746.1_Missense_Mutation_p.A564V|MAD1L1_ENST00000399654.2_Missense_Mutation_p.A656V			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	656					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TGGGTGCTCGGCGTACAGCGA	0.627000													8	12					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	108970442	108970442	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:108970442C>T	ENST00000276659.5	-	5	1102	c.482G>A	c.(481-483)cGc>cAc	p.R161H	RSPO2_ENST00000378439.2_Missense_Mutation_p.R97H|RSPO2_ENST00000517781.1_Missense_Mutation_p.R97H|RSPO2_ENST00000517939.1_Missense_Mutation_p.R94H	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	161	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			TCCACATGTGCGATTATTTCT	0.388000													25	50					0	0	1	0	0
WDR36	134430	broad.mit.edu	37	5	110439987	110439987	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:110439987C>T	ENST00000506538.2	+	8	1583	c.1010C>T	c.(1009-1011)gCc>gTc	p.A337V	WDR36_ENST00000505303.1_Missense_Mutation_p.A281V|WDR36_ENST00000513710.2_Missense_Mutation_p.A337V	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	337					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		ACAGCAATTGCCGGACTGACA	0.428000													26	115					0	0	1	0	0
UNK	85451	broad.mit.edu	37	17	73815809	73815809	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73815809G>A	ENST00000293218.3	+	13	1819	c.1819G>A	c.(1819-1821)Gcc>Acc	p.A607T	UNK_ENST00000589666.1_Missense_Mutation_p.A531T|RP11-552F3.4_ENST00000586808.1_RNA			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	531							nucleic acid binding|zinc ion binding			cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGGCGTGGCCGCCCTGGAGAA	0.592000													22	23					0	0	1	0	0
SLC35E1	79939	broad.mit.edu	37	19	16677423	16677423	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16677423G>A	ENST00000595753.1	-	4	693	c.676C>T	c.(676-678)Ctg>Ttg	p.L226L	CTD-3222D19.2_ENST00000409035.1_Silent_p.S419S|SLC35E1_ENST00000431408.1_Silent_p.L70L	NM_024881.4	NP_079157.3	Q96K37	S35E1_HUMAN	solute carrier family 35, member E1	226					transport	integral to membrane				central_nervous_system(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(2)|ovary(1)	15						TGGCAGCCCAGGATGTTGAGC	0.532000													17	34					0	0	1	0	0
ACAP2	23527	broad.mit.edu	37	3	195016454	195016454	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195016454G>A	ENST00000326793.6	-	17	1885	c.1655C>T	c.(1654-1656)gCa>gTa	p.A552V		NM_012287.5	NP_036419.3	Q15057	ACAP2_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	552					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	27						TTGGGCAGATGCTCTGACTTG	0.388000													26	34					0	0	1	0	0
SCGN	10590	broad.mit.edu	37	6	25661856	25661856	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:25661856G>A	ENST00000377961.2	+	3	398	c.230G>A	c.(229-231)cGc>cAc	p.R77H	SCGN_ENST00000334979.6_3'UTR	NM_006998.3	NP_008929.2	O76038	SEGN_HUMAN	secretagogin, EF-hand calcium binding protein	77	EF-hand 2.					extracellular region|transport vesicle membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						AAAGATGGTCGCATTCGGATG	0.403000													14	39					0	0	1	0	0
EPHB6	0	broad.mit.edu	37	7	142564789	142564789	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142564789C>T	ENST00000392957.2	+	11	2500	c.1713C>T	c.(1711-1713)taC>taT	p.Y571Y	EPHB6_ENST00000442129.1_Silent_p.Y571Y|EPHB6_ENST00000411471.2_Silent_p.Y294Y	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	571	Fibronectin type-III 2.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					ACGGCCCCTACGGGGGCAAAG	0.637000													17	24					0	0	1	0	0
NONO	4841	broad.mit.edu	37	X	70519912	70519912	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:70519912C>T	ENST00000535149.1	+	10	1778	c.1135C>T	c.(1135-1137)Cgt>Tgt	p.R379C	NONO_ENST00000490044.1_3'UTR|NONO_ENST00000373856.3_Missense_Mutation_p.R468C|NONO_ENST00000373841.1_Missense_Mutation_p.R468C|NONO_ENST00000276079.8_Missense_Mutation_p.R468C	NM_001145410.1	NP_001138882.1	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	468					DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	19	Renal(35;0.156)					CCCAAACAAACGTCGCCGATA	0.468000			T	TFE3	papillary renal cancer								8	26					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55929685	55929685	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:55929685G>A	ENST00000388975.3	-	2	121	c.5C>T	c.(4-6)gCa>gTa	p.A2V	SEPT14_ENST00000477628.1_5'UTR	NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	2					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TGTTCTTTCTGCCATGCTACA	0.289000													3	11					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	G	rs121913530		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:25398285C>G	ENST00000311936.3	-	2	225	c.34G>C	c.(34-36)Ggt>Cgt	p.G12R	KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000256078.4_Missense_Mutation_p.G12R	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			18	36					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128495288	128495288	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128495288C>T	ENST00000325888.8	+	43	7432	c.7171C>T	c.(7171-7173)Cac>Tac	p.H2391Y	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Missense_Mutation_p.H2358Y	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2391					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CAATGATGAGCACATCCCAGA	0.622000													38	53					0	0	1	0	0
SLC3A1	6519	broad.mit.edu	37	2	44502871	44502871	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:44502871C>T	ENST00000260649.6	+	1	273	c.197C>T	c.(196-198)gCg>gTg	p.A66V	SLC3A1_ENST00000410056.3_Missense_Mutation_p.A66V|SLC3A1_ENST00000409387.1_Missense_Mutation_p.A66V|SLC3A1_ENST00000409741.1_Missense_Mutation_p.A66V|SLC3A1_ENST00000409229.3_Missense_Mutation_p.A66V	NM_000341.3	NP_000332.2	Q07837	SLC31_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 1	66					carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(3)	26		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	CAGCCCTATGCGGGGATGCCC	0.622000													12	10					0	0	1	0	0
OXCT1	5019	broad.mit.edu	37	5	41794151	41794151	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:41794151G>A	ENST00000196371.5	-	13	1362	c.1202C>T	c.(1201-1203)gCg>gTg	p.A401V	OXCT1_ENST00000510634.1_Missense_Mutation_p.A4V|OXCT1_ENST00000513081.1_5'UTR|OXCT1_ENST00000509987.1_Missense_Mutation_p.A215V|OXCT1_ENST00000512084.1_Missense_Mutation_p.A4V	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	401					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	AACCTGCATCGCTCCTAGCAT	0.383000													49	98					0	0	1	0	0
PVRL3	25945	broad.mit.edu	37	3	110852711	110852711	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:110852711G>A	ENST00000485303.1	+	6	1574	c.1299G>A	c.(1297-1299)acG>acA	p.T433T	PVRL3_ENST00000493615.1_Intron|PVRL3_ENST00000319792.3_3'UTR	NM_001243286.1|NM_015480.2	NP_001230215.1|NP_056295.1	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3	433					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(3)	19						GAAGACGGACGTTTCGTGGAG	0.413000													7	70					0	0	1	0	0
DDX41	51428	broad.mit.edu	37	5	176943194	176943194	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176943194G>A	ENST00000507955.1	-	4	822	c.298_splice	c.e4-1	p.A100_splice	DDX41_ENST00000506965.1_5'UTR	NM_016222.2	NP_057306.2	Q9UJV9	DDX41_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	100					apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding					all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			CTCTTTGCGCGCTGAGAAAAG	0.537000													65	88					0	0	1	0	0
MAP1S	55201	broad.mit.edu	37	19	17838376	17838376	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17838376G>A	ENST00000324096.4	+	5	2334	c.2183G>A	c.(2182-2184)cGc>cAc	p.R728H	MAP1S_ENST00000597681.1_3'UTR|MAP1S_ENST00000544059.2_Missense_Mutation_p.R702H	NM_018174.4	NP_060644.4	Q66K74	MAP1S_HUMAN	microtubule-associated protein 1S	728	Necessary for association with microtubules.|Necessary for interaction with RASSF1 isoform A and isoform C.|Necessary for the microtubule-organizing center localization.|Pro-rich.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	25						CGGGCGCGGCGCTCGGCTTCC	0.697000													3	8					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99155420	99155420	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:99155420C>T	ENST00000074304.5	+	9	1039	c.646C>T	c.(646-648)Cga>Tga	p.R216*	INPP4A_ENST00000409540.3_Nonsense_Mutation_p.R216*|INPP4A_ENST00000523221.1_Nonsense_Mutation_p.R216*|INPP4A_ENST00000545415.1_Nonsense_Mutation_p.R216*|INPP4A_ENST00000409851.3_Nonsense_Mutation_p.R216*|INPP4A_ENST00000409016.3_Nonsense_Mutation_p.R216*|INPP4A_ENST00000409463.1_Intron	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	216					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						CGCTTCATTGCGAAAGGACAC	0.478000													4	19					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16895569	16895569	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16895569G>A	ENST00000430580.2	-	23	3500	c.2614_splice	c.e23+1	p.G871_splice	NBPF1_ENST00000420031.2_3'UTR|NBPF1_ENST00000432949.1_Intron	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	871	NBPF 4.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AGTACTCACCGCCTATGTCAA	0.498000													137	1186					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14942551	14942551	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:14942551G>A	ENST00000285046.5	+	9	3357	c.3247G>A	c.(3247-3249)Gac>Aac	p.D1083N	FGD5_ENST00000543601.1_Missense_Mutation_p.D842N|FGD5_ENST00000476851.1_3'UTR	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1083	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						CCGTGCCAACGACAGCATGGA	0.622000													15	37					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70991496	70991496	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:70991496C>T	ENST00000256389.3	-	2	373	c.129G>A	c.(127-129)tgG>tgA	p.W43*	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	0					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		CATTATGGAGCCATCTGTCTA	0.527000													4	74					0	0	1	0	0
CLNS1A	1207	broad.mit.edu	37	11	77336825	77336825	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:77336825C>T	ENST00000525428.1	-	3	391	c.301G>A	c.(301-303)Gac>Aac	p.D101N	CLNS1A_ENST00000532069.1_Intron|CLNS1A_ENST00000525064.1_Missense_Mutation_p.D101N|CLNS1A_ENST00000263309.3_Intron|CLNS1A_ENST00000528364.1_Missense_Mutation_p.D101N	NM_001293.2	NP_001284.1	P54105	ICLN_HUMAN	chloride channel, nucleotide-sensitive, 1A	101					blood circulation|cell volume homeostasis|chloride transport|ncRNA metabolic process|spliceosomal snRNP assembly	cytoskeleton|cytosol|nucleus|plasma membrane	protein binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	5	all_cancers(14;5.43e-17)|all_epithelial(13;1.78e-19)		Epithelial(5;1.02e-48)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			TCATCACTGTCTTCCTCTTCT	0.318000													9	17					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119203009	119203009	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:119203009C>T	ENST00000313400.4	-	22	3761	c.3661G>A	c.(3661-3663)Gcc>Acc	p.A1221T	ASTN2_ENST00000373996.3_Missense_Mutation_p.A1217T|ASTN2_ENST00000341734.4_Missense_Mutation_p.A273T|ASTN2_ENST00000361477.3_Missense_Mutation_p.A273T|ASTN2_ENST00000361209.2_Missense_Mutation_p.A1170T|ASTN2_ENST00000288520.5_Missense_Mutation_p.A322T			O75129	ASTN2_HUMAN	astrotactin 2	1221						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GTGTTGTAGGCCATCTGCTGC	0.498000													28	53					0	0	1	0	0
ZWINT	0	broad.mit.edu	37	10	58119813	58119813	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:58119813C>A	ENST00000373944.3	-	3	260	c.222G>T	c.(220-222)aaG>aaT	p.K74N	ZWINT_ENST00000395405.1_Missense_Mutation_p.K74N|ZWINT_ENST00000361148.6_Missense_Mutation_p.K74N			O95229	ZWINT_HUMAN	ZW10 interacting kinetochore protein	74					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)	20						GGTCGAGACCCTTAGCAGTGT	0.552000													19	39					2.89027e-11	3.10618e-11	1	1	0
USP28	57646	broad.mit.edu	37	11	113675698	113675698	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:113675698C>T	ENST00000003302.4	-	20	2539	c.2471G>A	c.(2470-2472)cGa>cAa	p.R824Q	USP28_ENST00000260188.5_Missense_Mutation_p.R792Q|USP28_ENST00000545540.1_Missense_Mutation_p.R667Q|USP28_ENST00000544967.1_Missense_Mutation_p.R500Q	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	824					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		ATGCTGAAGTCGAGGATCACT	0.428000													15	25					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895851	90895851	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:90895851C>T	ENST00000287934.2	+	1	2069	c.1656C>T	c.(1654-1656)atC>atT	p.I552I		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	552					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CCATCGTCATCGCCTGCTACT	0.607000													19	25					0	0	1	0	0
PRKAR1A	5573	broad.mit.edu	37	17	66524014	66524014	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:66524014G>A	ENST00000589228.1	+	8	870	c.742G>A	c.(742-744)Gaa>Aaa	p.E248K	PRKAR1A_ENST00000536854.2_Missense_Mutation_p.E248K|PRKAR1A_ENST00000586397.1_Missense_Mutation_p.E248K|PRKAR1A_ENST00000358598.2_Missense_Mutation_p.E248K|PRKAR1A_ENST00000588188.2_Missense_Mutation_p.E248K|PRKAR1A_ENST00000392711.1_Missense_Mutation_p.E248K	NM_001276289.1|NM_001278433.1	NP_001263218.1|NP_001265362.1	P10644	KAP0_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, alpha	248					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|soft_tissue(2)|stomach(2)|testis(1)|thyroid(2)|upper_aerodigestive_tract(1)	31	Breast(10;1.64e-13)					GATGTATGAGGAATTCCTTAG	0.358000			"""T, Mis, N, F, S"""	RET	papillary thyroid	"""myxoma, endocrine, papillary thyroid"""			Primary Pigmented Nodular Adrenocortical Disease, Familial;Carney Complex;Cardiac Myxomas, Familial Clustering of				19	29					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63554635	63554635	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:63554635G>A	ENST00000307078.5	-	2	417	c.104C>T	c.(103-105)cCg>cTg	p.P35L	AXIN2_ENST00000375702.5_Missense_Mutation_p.P35L|CTD-2535L24.2_ENST00000577662.1_3'UTR	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	35					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						TGGCTGACACGGTGGGGTCTC	0.667000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				17	24					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136634554	136634554	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136634554C>T	ENST00000371851.1	-	26	2714	c.2389G>A	c.(2389-2391)Gct>Act	p.A797T	VAV2_ENST00000406606.3_Intron|VAV2_ENST00000371850.3_Missense_Mutation_p.A807T			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	807					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CAGAAGGGAGCGGAGGGGCCC	0.637000													3	7					0	0	1	0	0
TFB1M	51106	broad.mit.edu	37	6	155581523	155581523	+	Silent	SNP	G	G	A	rs149796947	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:155581523G>A	ENST00000367166.4	-	6	733	c.678C>T	c.(676-678)ggC>ggT	p.G226G		NM_016020.3	NP_057104.2	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		AGTGCACCACGCCCACGTCCA	0.438000													11	16					0	0	1	0	0
PLIN2	123	broad.mit.edu	37	9	19116297	19116297	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:19116297C>A	ENST00000276914.2	-	8	1442	c.1263G>T	c.(1261-1263)gaG>gaT	p.E421D	PLIN2_ENST00000411567.1_Missense_Mutation_p.E340D	NM_001122.3	NP_001113.2	Q99541	PLIN2_HUMAN	perilipin 2	421					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	19						TCTTGTCCATCTCTGCACCTT	0.498000													27	47					5.91797e-21	6.56533e-21	1	1	0
KIF13B	23303	broad.mit.edu	37	8	28974382	28974382	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:28974382C>T	ENST00000524189.1	-	31	3841	c.3803G>A	c.(3802-3804)cGc>cAc	p.R1268H	CTD-2647L4.1_ENST00000523661.1_RNA	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1268					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		GATTCTCTTGCGTAACACCAG	0.592000													22	26					0	0	1	0	0
NKTR	4820	broad.mit.edu	37	3	42679568	42679568	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:42679568G>T	ENST00000232978.8	+	13	2560	c.2372G>T	c.(2371-2373)aGg>aTg	p.R791M	RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	791	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GGTAGAGACAGGTCTTCATGT	0.413000													21	35					2.21704e-12	2.3975e-12	1	1	0
ERN1	2081	broad.mit.edu	37	17	62130708	62130708	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62130708C>T	ENST00000433197.2	-	16	2072	c.1977G>A	c.(1975-1977)gcG>gcA	p.A659A		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	659	Protein kinase.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						GGCCGAGATGCGCAAAGTCCT	0.582000													10	26					0	0	1	0	0
KIAA0355	9710	broad.mit.edu	37	19	34818459	34818459	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:34818459C>T	ENST00000299505.6	+	4	1712	c.839C>T	c.(838-840)gCt>gTt	p.A280V		NM_014686.3	NP_055501.2	O15063	K0355_HUMAN	KIAA0355	280										breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					ATCGACAGTGCTTTGCAAGTA	0.393000													18	40					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	68107673	68107673	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:68107673G>A	ENST00000262210.5	+	29	3542	c.3511G>A	c.(3511-3513)Gga>Aga	p.G1171R	CSPP1_ENST00000412460.1_Missense_Mutation_p.G826R|ARFGEF1_ENST00000520381.1_Intron|CSPP1_ENST00000521168.1_3'UTR	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	1206						centrosome|microtubule|spindle		p.G1171*(1)		NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AGGGGATGACGGATCAAACTC	0.532000													71	105					0	0	1	0	0
ADTRP	84830	broad.mit.edu	37	6	11768593	11768593	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:11768593C>T	ENST00000414691.3	-	2	587	c.177G>A	c.(175-177)ggG>ggA	p.G59G	ADTRP_ENST00000379413.2_Silent_p.G59G|ADTRP_ENST00000229583.5_Silent_p.G77G	NM_032744.3	NP_116133.1	Q96IZ2	CF105_HUMAN	androgen-dependent TFPI-regulating protein	59						integral to membrane											GGCAGGTGACCCCGTAGAAAA	0.418000													35	69					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	662797	662797	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:662797G>A	ENST00000266383.5	+	14	1721	c.1708G>A	c.(1708-1710)Gca>Aca	p.A570T		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	570						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GTCGTACATCGCAGAGCAGAG	0.662000													22	25					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123058925	123058925	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:123058925G>A	ENST00000333479.7	+	27	2557	c.2380G>A	c.(2380-2382)Gac>Aac	p.D794N	KNTC1_ENST00000450485.2_Missense_Mutation_p.D757N	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	794					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		ATCTGACACGGACGTAAGTAA	0.368000													4	13					0	0	1	0	0
ADC	113451	broad.mit.edu	37	1	33560279	33560279	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33560279C>T	ENST00000294517.6	+	8	1305	c.718C>T	c.(718-720)Cct>Tct	p.P240S	ADC_ENST00000373443.3_Missense_Mutation_p.P240S|ADC_ENST00000398167.1_Missense_Mutation_p.P240S|ADC_ENST00000358680.3_Intron|ADC_ENST00000373440.1_Intron|ADC_ENST00000484656.1_3'UTR|ADC_ENST00000373441.1_Missense_Mutation_p.P240S	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	240					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	TGGTGGCTTCCCTGGCACAGA	0.577000											OREG0013339	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	39					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30897908	30897908	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:30897908C>T	ENST00000375712.3	+	2	495	c.328C>T	c.(328-330)Cgt>Tgt	p.R110C		NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	110	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding	p.R110C(1)		NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGAAGGAATCCGTGGTGACCC	0.463000													38	38					0	0	1	0	0
SLBP	7884	broad.mit.edu	37	4	1696566	1696566	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1696566G>A	ENST00000489418.1	-	7	997	c.629_splice	c.e7-1	p.H211_splice	SLBP_ENST00000318386.4_Splice_Site_p.H218_splice|SLBP_ENST00000429429.2_Splice_Site_p.H172_splice|SLBP_ENST00000488267.1_Splice_Site_p.H176_splice	NM_006527.2	NP_006518.1	Q14493	SLBP_HUMAN	stem-loop binding protein	211					DNA replication involved in S phase|histone mRNA 3'-end processing|mRNA export from nucleus|regulation of S phase|termination of RNA polymerase II transcription	cytosol|histone pre-mRNA 3'end processing complex|nucleoplasm	histone pre-mRNA DCP binding|histone pre-mRNA stem-loop binding|protein binding			endometrium(1)|large_intestine(2)|lung(2)	5		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.0055)			TCTACAGGGTGTCTGTTAAAC	0.498000													19	32					0	0	1	0	0
PCDHA1	0	broad.mit.edu	37	5	140167325	140167325	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140167325G>A	ENST00000504120.2	+	1	1450	c.1450G>A	c.(1450-1452)Gcg>Acg	p.A484T	PCDHA1_ENST00000394633.3_Missense_Mutation_p.A484T|PCDHA1_ENST00000378133.3_Missense_Mutation_p.A484T	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGCGGACGCGCAGGAGAA	0.662000													26	46					0	0	1	0	0
DTNBP1	84062	broad.mit.edu	37	6	15638018	15638018	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:15638018G>A	ENST00000338950.5	-	4	284	c.179C>T	c.(178-180)gCt>gTt	p.A60V	DTNBP1_ENST00000355917.3_Missense_Mutation_p.A60V|DTNBP1_ENST00000344537.5_Missense_Mutation_p.A60V	NM_183040.2	NP_898861.1	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1	60					actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|skin(2)	14	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			GTGAAGTGCAGCCCATGTATC	0.358000									Hermansky-Pudlak syndrome				25	39					0	0	1	0	0
C17orf104	284071	broad.mit.edu	37	17	42744798	42744798	+	Missense_Mutation	SNP	G	G	T	rs144667654		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42744798G>T	ENST00000409122.2	+	5	1661	c.1519G>T	c.(1519-1521)Gct>Tct	p.A507S	C17orf104_ENST00000359945.3_Missense_Mutation_p.A507S|C17orf104_ENST00000409464.1_Missense_Mutation_p.A341S	NM_001145080.2	NP_001138552.2	A2RUB1	CQ104_HUMAN	chromosome 17 open reading frame 104	507										autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|pancreas(1)|skin(1)	24						TTTAAGTGCAGCTTCAAAAGG	0.333000													17	23					2.35188e-11	2.53156e-11	1	1	0
LRRC32	2615	broad.mit.edu	37	11	76371565	76371565	+	Missense_Mutation	SNP	G	G	A	rs150096749		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:76371565G>A	ENST00000407242.2	-	3	1314	c.1072C>T	c.(1072-1074)Cgc>Tgc	p.R358C	LRRC32_ENST00000260061.5_Missense_Mutation_p.R358C|LRRC32_ENST00000464145.1_Intron|LRRC32_ENST00000404995.1_Missense_Mutation_p.R358C|AP001189.4_ENST00000447519.1_RNA	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	358						integral to plasma membrane		p.R358C(1)		endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						GAGCCTAAGCGCCGGGCCTCA	0.597000													3	13					0	0	1	0	0
CUL4B	8450	broad.mit.edu	37	X	119694003	119694003	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:119694003G>A	ENST00000371322.5	-	1	552	c.491C>T	c.(490-492)aCc>aTc	p.T164I	CUL4B_ENST00000336592.6_Missense_Mutation_p.T169I|CUL4B_ENST00000404115.3_Missense_Mutation_p.T182I	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B	182	Ser-rich.				cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GCTAGAGACGGTGGTAGAAGA	0.418000													32	7					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74648511	74648511	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:74648511C>T	ENST00000354431.4	-	3	475	c.284G>A	c.(283-285)gGa>gAa	p.G95E	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.G95E|LRRIQ3_ENST00000370911.3_Missense_Mutation_p.G95E|LRRIQ3_ENST00000370909.2_Intron	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	95										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						GTTCTTCAATCCATTCCAAAA	0.308000													8	44					0	0	1	0	0
NRBP1	29959	broad.mit.edu	37	2	27664668	27664668	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27664668G>A	ENST00000233557.3	+	19	2429	c.1597G>A	c.(1597-1599)Gtc>Atc	p.V533I	NRBP1_ENST00000379863.3_Missense_Mutation_p.V541I|NRBP1_ENST00000379852.3_Missense_Mutation_p.V533I			Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein 1	533					ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					CGCTGTCACCGTCTCCTCTTA	0.587000													49	56					0	0	1	0	0
LOXL1	4016	broad.mit.edu	37	15	74241882	74241882	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:74241882G>A	ENST00000261921.7	+	6	2011	c.1685G>A	c.(1684-1686)cGc>cAc	p.R562H	LOXL1_ENST00000567675.1_Intron	NM_005576.2	NP_005567.2	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1	562	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10						TACACAGGTCGCTACGTTTCT	0.507000													13	81					0	0	1	0	0
TRAV38-1	0	broad.mit.edu	37	14	22740374	22740374	+	RNA	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22740374A>G	ENST00000390464.2	+	0	281																											AAAGCAGCCAAATCCTTCAGT	0.483000													5	32					0	0	1	0	0
IDI2	91734	broad.mit.edu	37	10	1065665	1065665	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:1065665A>G	ENST00000277517.1	-	5	540	c.476T>C	c.(475-477)gTc>gCc	p.V159A	GTPBP4_ENST00000360803.4_3'UTR	NM_033261.2	NP_150286.1	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	159	Nudix hydrolase.				carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	9		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		GTTCAGAGTGACGTTTTTCCT	0.493000													10	61					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125526622	125526622	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:125526622C>T	ENST00000241305.3	-	10	1500	c.1346G>A	c.(1345-1347)gGa>gAa	p.G449E	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	449					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GATGTCAATTCCATCGTGGGT	0.542000													16	22					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195475931	195475931	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195475931G>A	ENST00000463781.3	-	24	16335	c.15876C>T	c.(15874-15876)aaC>aaT	p.N5292N	MUC4_ENST00000475231.1_Silent_p.N5240N|MUC4_ENST00000349607.4_Silent_p.N1005N|MUC4_ENST00000346145.4_Silent_p.N1056N	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	2049					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GCGTGCTCACGTTCACTGTCG	0.517000													4	23					0	0	1	0	0
SLC22A12	116085	broad.mit.edu	37	11	64368360	64368360	+	Silent	SNP	C	C	T	rs145764379		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64368360C>T	ENST00000377574.1	+	9	2295	c.1548C>T	c.(1546-1548)ccC>ccT	p.P516P	SLC22A12_ENST00000336464.7_Silent_p.P482P|SLC22A12_ENST00000377567.2_Silent_p.P408P|SLC22A12_ENST00000473690.1_Silent_p.P295P|SLC22A12_ENST00000377572.1_Silent_p.P408P	NM_144585.2	NP_653186.2	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12	516					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						TGCTTCTGCCCGAGACCCAGA	0.667000													25	59					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10524604	10524604	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:10524604G>A	ENST00000396560.2	+	3	354	c.127G>A	c.(127-129)Ggg>Agg	p.G43R	ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000396559.1_Missense_Mutation_p.G43R|ATF7IP2_ENST00000324570.5_Missense_Mutation_p.G43R|ATF7IP2_ENST00000356427.2_Missense_Mutation_p.G43R	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						AACAGCAATTGGGAGTAATGT	0.418000													27	39					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55594809	55594809	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55594809T>C	ENST00000378397.1	+	1	115	c.115T>C	c.(115-117)Ttg>Ctg	p.L39L		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				TGGAGTCACGTTGTTAGCCAA	0.507000										HNSCC(27;0.073)			5	169					0	0	1	0	0
ZCWPW1	55063	broad.mit.edu	37	7	99998766	99998766	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99998766G>A	ENST00000398027.2	-	18	2065	c.1818C>T	c.(1816-1818)gaC>gaT	p.D606D	ZCWPW1_ENST00000490721.1_Silent_p.D435D|ZCWPW1_ENST00000360951.4_3'UTR|ZCWPW1_ENST00000324725.6_Silent_p.D435D	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	606							zinc ion binding	p.D606D(1)		breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGGAGGCTTCGTCCTCAAGGG	0.622000													9	24					0	0	1	0	0
OTUD3	23252	broad.mit.edu	37	1	20220882	20220882	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:20220882G>A	ENST00000375120.3	+	3	393	c.392G>A	c.(391-393)gGt>gAt	p.G131D	OTUD3_ENST00000466697.1_3'UTR	NM_015207.1	NP_056022.1	Q5T2D3	OTUD3_HUMAN	OTU domain containing 3	131	OTU.									breast(1)|kidney(2)|large_intestine(4)|lung(1)|skin(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000276)|Lung NSC(340;0.000338)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.12e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.000408)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCAAAGCCTGGTACTTTTGCT	0.398000													19	32					0	0	1	0	0
PSMD5	5711	broad.mit.edu	37	9	123580192	123580192	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:123580192C>T	ENST00000210313.3	-	10	1581	c.1507G>A	c.(1507-1509)Gcc>Acc	p.A503T	PSMD5_ENST00000373904.5_Missense_Mutation_p.A460T|PSMD5_ENST00000604848.1_Intron	NM_001270427.1|NM_005047.3	NP_001257356.1|NP_005038.1	Q16401	PSMD5_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	503					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)	10						AATCATTCGGCTCCTTCTACT	0.423000													26	42					0	0	1	0	0
SURF6	6838	broad.mit.edu	37	9	136198745	136198745	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136198745C>T	ENST00000372022.4	-	5	1311	c.1046G>A	c.(1045-1047)cGc>cAc	p.R349H	SURF6_ENST00000468290.1_5'UTR	NM_006753.4	NP_006744.2	O75683	SURF6_HUMAN	surfeit 6	349						granular component	DNA binding|RNA binding			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	12				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		CGGCAGGATGCGGCCCTTCTT	0.697000													3	7					0	0	1	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39387493	39387493	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:39387493C>T	ENST00000402182.3	+	6	935	c.880C>T	c.(880-882)Cgt>Tgt	p.R294C	APOBEC3B_ENST00000333467.3_Missense_Mutation_p.R294C|APOBEC3B_ENST00000407298.3_Missense_Mutation_p.R269C			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	294					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					CGGGGAAGTGCGTGCGTTCCT	0.582000													55	117					0	0	1	0	0
HSPA4	3308	broad.mit.edu	37	5	132437570	132437570	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:132437570G>T	ENST00000304858.2	+	17	2446	c.2157_splice	c.e17+1	p.K719_splice		NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	719					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCAAAAACAAGGTAACTTTTT	0.328000													4	16					0.00024832	0.000253518	1	1	0
EGR1	1958	broad.mit.edu	37	5	137803153	137803153	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137803153G>A	ENST00000239938.4	+	2	1287	c.1015G>A	c.(1015-1017)Gct>Act	p.A339T		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	339					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACGCCCTTACGCTTGCCCAGT	0.647000													22	35					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47959821	47959821	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:47959821C>T	ENST00000318711.7	+	17	2139	c.1956C>T	c.(1954-1956)aaC>aaT	p.N652N	DIP2A_ENST00000427143.2_Silent_p.N587N|DIP2A_ENST00000400274.1_Silent_p.N647N|DIP2A_ENST00000466639.1_Silent_p.N608N|DIP2A_ENST00000457905.3_Silent_p.N651N|DIP2A_ENST00000435722.3_Silent_p.N651N|DIP2A_ENST00000417564.2_Silent_p.N651N	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	651					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CCTTCCTCAACGTCTTCCAGT	0.587000													28	22					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124827614	124827614	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:124827614G>A	ENST00000356219.3	-	34	5049	c.4894C>T	c.(4894-4896)Cgc>Tgc	p.R1632C	NCOR2_ENST00000404621.1_Missense_Mutation_p.R1615C|NCOR2_ENST00000429285.2_Missense_Mutation_p.R1615C|NCOR2_ENST00000405201.1_Missense_Mutation_p.R1625C|NCOR2_ENST00000404121.2_Missense_Mutation_p.R1186C|NCOR2_ENST00000397355.1_Missense_Mutation_p.R1616C	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1633					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		ATGTGGCTGCGATACAGGTCC	0.672000													8	17					0	0	1	0	0
NBR1	4077	broad.mit.edu	37	17	41341626	41341626	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41341626G>A	ENST00000422280.1	+	8	961	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K	NBR1_ENST00000341165.6_Missense_Mutation_p.E168K|NBR1_ENST00000590996.1_Missense_Mutation_p.E168K|NBR1_ENST00000589872.1_Missense_Mutation_p.E168K|NBR1_ENST00000542611.1_Missense_Mutation_p.E147K|NBR1_ENST00000389312.4_Missense_Mutation_p.E168K	NM_031858.2	NP_114064.1	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	168					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding	p.E168K(1)		NS(1)|breast(1)|cervix(1)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	24		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		AGTGGTTAACGAAACGGTTGA	0.393000													22	34					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243303262	243303262	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:243303262G>A	ENST00000366542.1	-	16	4258	c.4207C>T	c.(4207-4209)Cgg>Tgg	p.R1403W	CEP170_ENST00000481987.1_Missense_Mutation_p.R139W|CEP170_ENST00000366544.1_Missense_Mutation_p.R1305W|CEP170_ENST00000468254.1_5'UTR|RP11-261C10.5_ENST00000439562.1_RNA|CEP170_ENST00000490813.1_Missense_Mutation_p.R112W|CEP170_ENST00000366543.1_Missense_Mutation_p.R1279W	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	1403	Targeting to centrosomes.|Targeting to microtubules.					centriole|microtubule|spindle		p.R1403W(1)		NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CAGGTTCTCCGCCTTGTAATT	0.428000													11	23					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41025863	41025863	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41025863C>T	ENST00000352632.3	+	16	3545	c.3459C>T	c.(3457-3459)agC>agT	p.S1153S	SPTBN4_ENST00000595535.1_Silent_p.S1153S|SPTBN4_ENST00000338932.3_Silent_p.S1153S|SPTBN4_ENST00000598249.1_Silent_p.S1153S|SPTBN4_ENST00000344104.3_Silent_p.S1153S			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1153					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGGCGGCCAGCGAGGCGCTGC	0.687000													3	5					0	0	1	0	0
HGS	9146	broad.mit.edu	37	17	79667775	79667775	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79667775G>A	ENST00000329138.4	+	20	2202	c.2067G>A	c.(2065-2067)ccG>ccA	p.P689P		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	689	Gln-rich.|Interaction with NF2.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			CTCAGCCTCCGCAGTCCAGCA	0.662000													8	18					0	0	1	0	0
CHST3	9469	broad.mit.edu	37	10	73767545	73767545	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:73767545C>T	ENST00000373115.4	+	3	1193	c.756C>T	c.(754-756)tgC>tgT	p.C252C		NM_004273.4	NP_004264.2	Q7LGC8	CHST3_HUMAN	carbohydrate (chondroitin 6) sulfotransferase 3	252					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity			endometrium(1)|lung(5)	6						ACCGCCGCTGCGGCCCCCTCA	0.682000													5	13					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88162166	88162166	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:88162166C>T	ENST00000357081.3	-	26	3683	c.3539G>A	c.(3538-3540)cGa>cAa	p.R1180Q	AGTPBP1_ENST00000376109.3_Missense_Mutation_p.R1192Q|AGTPBP1_ENST00000376083.3_Missense_Mutation_p.R1140Q|AGTPBP1_ENST00000337006.4_3'UTR|AGTPBP1_ENST00000432218.1_Missense_Mutation_p.D629N			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1180					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						TTCAAGGAATCGAGGTTCATC	0.378000													5	47					0	0	1	0	0
PRICKLE1	0	broad.mit.edu	37	12	42854165	42854165	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:42854165G>A	ENST00000455697.1	-	8	2227	c.1942C>T	c.(1942-1944)Cgg>Tgg	p.R648W	RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.R648W|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.R648W|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.R648W|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.R648W	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	648					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GGAGGCTGCCGGATTTCAATG	0.507000													25	48					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45523680	45523680	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:45523680G>A	ENST00000361462.2	+	16	4670	c.4487G>A	c.(4486-4488)cGa>cAa	p.R1496Q	FAM179B_ENST00000382233.2_3'UTR|FAM179B_ENST00000361577.3_Missense_Mutation_p.R1443Q			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	1443							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						AAAGGAAGACGATCTCATACT	0.343000													32	43					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85343171	85343171	+	Missense_Mutation	SNP	C	C	T	rs118045501	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:85343171C>T	ENST00000299927.3	+	7	3258	c.3236C>T	c.(3235-3237)aCg>aTg	p.T1079M	ZNF592_ENST00000560079.2_Missense_Mutation_p.T1079M			Q92610	ZN592_HUMAN	zinc finger protein 592	1079					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TTGAGCCAGACGTCCAAAGTG	0.582000													29	43					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48680423	48680423	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48680423C>T	ENST00000352832.5	+	20	4335	c.3963C>T	c.(3961-3963)agC>agT	p.S1321S	CACNA1G_ENST00000513689.2_Silent_p.S1344S|CACNA1G_ENST00000507510.2_Silent_p.S1344S|CACNA1G_ENST00000512389.1_Silent_p.S1344S|CACNA1G_ENST00000514079.1_Silent_p.S1344S|CACNA1G_ENST00000510115.1_Silent_p.S1321S|CACNA1G_ENST00000510366.1_Silent_p.S1344S|CACNA1G_ENST00000515411.1_Silent_p.S1344S|CACNA1G_ENST00000515765.1_Silent_p.S1344S|CACNA1G_ENST00000507896.1_Silent_p.S1344S|CACNA1G_ENST00000503485.1_Silent_p.S1344S|CACNA1G_ENST00000358244.5_Silent_p.S1321S|CACNA1G_ENST00000513964.1_Silent_p.S1344S|CACNA1G_ENST00000505165.1_Silent_p.S1344S|CACNA1G_ENST00000515165.1_Silent_p.S1344S|CACNA1G_ENST00000442258.2_Silent_p.S1321S|CACNA1G_ENST00000360761.4_Silent_p.S1321S|CACNA1G_ENST00000502264.1_Silent_p.S1321S|CACNA1G_ENST00000514181.1_Silent_p.S1344S|CACNA1G_ENST00000507336.1_Silent_p.S1344S|CACNA1G_ENST00000507609.1_Silent_p.S1344S|CACNA1G_ENST00000359106.5_Silent_p.S1344S|CACNA1G_ENST00000514717.1_Silent_p.S1321S|CACNA1G_ENST00000429973.2_Silent_p.S1344S|CACNA1G_ENST00000354983.4_Silent_p.S1321S|CACNA1G_ENST00000416767.4_Silent_p.S1344S	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1344					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	ACCTGCGGAGCAGTTGGAACG	0.647000													24	55					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287624	16287624	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:16287624C>T	ENST00000343518.6	-	1	313	c.262G>A	c.(262-264)Gat>Aat	p.D88N		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	88										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						ATAGCAGAATCGTCGTGGTCT	0.607000													8	301					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99641123	99641123	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:99641123C>T	ENST00000345514.2	-	3	2103	c.1837G>A	c.(1837-1839)Gcc>Acc	p.A613T	BCL11B_ENST00000357195.3_Missense_Mutation_p.A684T|BCL11B_ENST00000443726.2_Missense_Mutation_p.A490T	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	684	Gly-rich.					nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CGCTTGGCGGCGCTGTTGAGC	0.741000			T	TLX3	T-ALL								9	20					0	0	1	0	0
CEP57	9702	broad.mit.edu	37	11	95532505	95532505	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:95532505G>A	ENST00000325542.5	+	2	393	c.155G>A	c.(154-156)cGc>cAc	p.R52H	CEP57_ENST00000325486.5_Missense_Mutation_p.R52H|CEP57_ENST00000538658.1_Missense_Mutation_p.R52H|CEP57_ENST00000537677.1_Missense_Mutation_p.R25H|CEP57_ENST00000541150.1_Missense_Mutation_p.R43H	NM_001243776.1|NM_014679.4	NP_001230705.1|NP_055494.2	Q86XR8	CEP57_HUMAN	centrosomal protein 57kDa	52					fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GATCTACGACGCTCCCCAAGT	0.418000									Mosaic Variegated Aneuploidy Syndrome				9	117					0	0	1	0	0
TAS2R5	54429	broad.mit.edu	37	7	141490986	141490986	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:141490986G>A	ENST00000247883.4	+	1	970	c.825G>A	c.(823-825)ggG>ggA	p.G275G		NM_018980.2	NP_061853.1	Q9NYW4	TA2R5_HUMAN	taste receptor, type 2, member 5	275					chemosensory behavior|sensory perception of taste		taste receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9	Melanoma(164;0.0171)					TGATCATGGGGATTCCTAGGG	0.498000													26	64					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179486290	179486290	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179486290C>T	ENST00000589042.1	-	245	45485	c.45261G>A	c.(45259-45261)ctG>ctA	p.L15087L	TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Silent_p.L6214L|TTN_ENST00000591111.1_Silent_p.L13446L|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Silent_p.L6022L|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Silent_p.L12519L|TTN_ENST00000359218.5_Silent_p.L6147L|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13446	Fibronectin type-III 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGAATGACCAGGATTCTCT	0.453000													7	20					0	0	1	0	0
TXNDC15	79770	broad.mit.edu	37	5	134223831	134223831	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:134223831G>T	ENST00000358387.4	+	2	1175	c.550G>T	c.(550-552)Gga>Tga	p.G184*	TXNDC15_ENST00000546290.1_Nonsense_Mutation_p.G161*	NM_024715.3	NP_078991.3	Q96J42	TXD15_HUMAN	thioredoxin domain containing 15	184	Thioredoxin.				cell redox homeostasis	integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AAACATTACAGGATTAGAAAA	0.368000													9	20					0.00448238	0.00453641	1	1	0
TAF5L	27097	broad.mit.edu	37	1	229730823	229730823	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:229730823C>T	ENST00000258281.2	-	5	1156	c.991G>A	c.(991-993)Gca>Aca	p.A331T	TAF5L_ENST00000366676.1_Missense_Mutation_p.A331T	NM_014409.3	NP_055224.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	331					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				TCCGTGCCTGCATTATCATCC	0.517000													15	35					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31731813	31731813	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31731813G>A	ENST00000266269.5	-	3	2001	c.1372C>T	c.(1372-1374)Cgc>Tgc	p.R458C	RP3-400N23.6_ENST00000440456.1_RNA|RP3-400N23.6_ENST00000451161.1_RNA|PATZ1_ENST00000405309.3_Missense_Mutation_p.R458C|PATZ1_ENST00000351933.4_Missense_Mutation_p.R458C	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	458					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						AGGTGGGAGCGCAGACGGTCT	0.562000													18	26					0	0	1	0	0
BAG6	7917	broad.mit.edu	37	6	31608917	31608917	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31608917C>A	ENST00000404765.2	-	20	3040	c.2751G>T	c.(2749-2751)caG>caT	p.Q917H	BAG6_ENST00000375976.4_Missense_Mutation_p.Q881H|BAG6_ENST00000362049.6_Missense_Mutation_p.Q881H|BAG6_ENST00000211379.5_Missense_Mutation_p.Q881H|BAG6_ENST00000439687.2_Missense_Mutation_p.Q755H|BAG6_ENST00000375964.6_Missense_Mutation_p.Q887H			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	887					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GCTCCATCTGCTGTCCCCCCA	0.517000													33	45					3.86903e-22	4.30158e-22	1	1	0
ERF	2077	broad.mit.edu	37	19	42753014	42753014	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42753014G>A	ENST00000222329.4	-	4	1407	c.1250C>T	c.(1249-1251)gCc>gTc	p.A417V	ERF_ENST00000440177.2_Missense_Mutation_p.A342V|AC006486.9_ENST00000594664.1_Intron	NM_006494.2	NP_006485.2	P50548	ERF_HUMAN	Ets2 repressor factor	417					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	17		Prostate(69;0.00682)				GGGCGGTGGGGCTAGCGCCCC	0.677000													41	49					0	0	1	0	0
HOOK2	29911	broad.mit.edu	37	19	12883026	12883026	+	Missense_Mutation	SNP	G	G	A	rs145148176	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12883026G>A	ENST00000264827.5	-	7	667	c.497C>T	c.(496-498)aCg>aTg	p.T166M	HOOK2_ENST00000589965.1_Intron|HOOK2_ENST00000397668.3_Missense_Mutation_p.T166M	NM_001100176.1	NP_001093646.1	Q96ED9	HOOK2_HUMAN	hook microtubule-tethering protein 2	166	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(5)|skin(1)	20						GTTGCCATACGTCTCTGGTGA	0.507000													27	38					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150028074	150028074	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150028074G>A	ENST00000394243.1	+	3	1343	c.969G>A	c.(967-969)acG>acA	p.T323T	SYNPO_ENST00000522122.1_Silent_p.T323T|SYNPO_ENST00000518872.1_3'UTR|SYNPO_ENST00000307662.4_Silent_p.T79T|SYNPO_ENST00000519664.1_Silent_p.T79T	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	323					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAGTGCCACGCTCACCACAC	0.592000													7	78					0	0	1	0	0
ZNF214	0	broad.mit.edu	37	11	7021457	7021457	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7021457T>C	ENST00000278314.4	-	3	1772	c.1457A>G	c.(1456-1458)cAc>cGc	p.H486R	ZNF214_ENST00000536068.1_Missense_Mutation_p.H486R	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	486					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		TTGATGAGTGTGAAGCTTTGA	0.453000													45	44					0	0	1	0	0
DCAF15	90379	broad.mit.edu	37	19	14070278	14070278	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:14070278G>A	ENST00000254337.6	+	7	1227	c.1206G>A	c.(1204-1206)acG>acA	p.T402T		NM_138353.2	NP_612362.2	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	402										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)	11						GAGAGGGGACGGAGCCGGAGG	0.697000													12	25					0	0	1	0	0
HTR7	3363	broad.mit.edu	37	10	92509039	92509039	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:92509039G>A	ENST00000371721.3	-	2	1094	c.852C>T	c.(850-852)gaC>gaT	p.D284D	HTR7_ENST00000277874.6_Silent_p.D284D|HTR7_ENST00000336152.3_Silent_p.D284D|HTR7_ENST00000371719.2_Silent_p.D284D			P34969	5HT7R_HUMAN	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	284					blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	CGATGACGCTGTCTGGCTCCA	0.502000													14	11					0	0	1	0	0
ZBTB4	57659	broad.mit.edu	37	17	7367125	7367125	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7367125C>T	ENST00000311403.4	-	4	1515	c.1176G>A	c.(1174-1176)ccG>ccA	p.P392P	ZBTB4_ENST00000380599.4_Silent_p.P392P	NM_020899.3	NP_065950.2	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(3)|skin(6)	36		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		CAAGGAGGCCCGGGCTAATGC	0.577000													33	39					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99549847	99549847	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:99549847G>A	ENST00000376460.1	-	15	1684	c.1604C>T	c.(1603-1605)gCa>gTa	p.A535V	DOCK9_ENST00000339416.2_Missense_Mutation_p.A536V|DOCK9_ENST00000448493.2_Missense_Mutation_p.A547V|DOCK9_ENST00000442173.1_Missense_Mutation_p.A535V	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	536					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ATTTCCAGATGCATCCTTAAA	0.358000													31	61					0	0	1	0	0
FHOD3	80206	broad.mit.edu	37	18	34156465	34156465	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:34156465G>A	ENST00000257209.4	+	6	685	c.563G>A	c.(562-564)cGc>cAc	p.R188H	FHOD3_ENST00000591635.1_5'UTR|FHOD3_ENST00000590592.1_Missense_Mutation_p.R188H|FHOD3_ENST00000359247.4_Missense_Mutation_p.R188H|FHOD3_ENST00000445677.1_Missense_Mutation_p.R188H	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	188	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				GTAATAAACCGCAATGAAACC	0.373000													19	31					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110897213	110897213	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:110897213T>A	ENST00000265171.5	+	13	2320	c.1875T>A	c.(1873-1875)agT>agA	p.S625R	EGF_ENST00000503392.1_Missense_Mutation_p.S625R|EGF_ENST00000509793.1_Missense_Mutation_p.S583R	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	625					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GAATTGAAAGTTCTTCCCTCC	0.393000													64	55					0	0	1	0	0
EEF1DP3	0	broad.mit.edu	37	13	32527390	32527390	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:32527390G>T	ENST00000428783.1	+	0	1090																											GGAAGCTGCAGATTCAGCGTG	0.612000													3	18					0.115264	0.115739	1	1	0
RASGRF1	5923	broad.mit.edu	37	15	79356790	79356790	+	Missense_Mutation	SNP	C	C	T	rs144681233		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:79356790C>T	ENST00000419573.3	-	2	629	c.355G>A	c.(355-357)Gaa>Aaa	p.E119K	RASGRF1_ENST00000558480.2_Missense_Mutation_p.E119K|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	119	PH 1.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GCCACCCATTCGTCACAATCT	0.527000													36	69					0	0	1	0	0
PRRC2B	84726	broad.mit.edu	37	9	134350749	134350749	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:134350749G>A	ENST00000357304.4	+	15	3288	c.3233G>A	c.(3232-3234)gGt>gAt	p.G1078D	PRRC2B_ENST00000372249.1_5'UTR|PRRC2B_ENST00000458550.1_Intron|PRRC2B_ENST00000405995.1_Intron	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	1078							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						ACTTTTCGTGGTCGGCCTGCT	0.637000													7	14					0	0	1	0	0
NUDT16L1	84309	broad.mit.edu	37	16	4743810	4743810	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4743810G>A	ENST00000405142.1	+	1	92	c.83G>A	c.(82-84)tGc>tAc	p.C28Y	NUDT16L1_ENST00000586536.1_Missense_Mutation_p.C28Y|NUDT16L1_ENST00000304301.6_Missense_Mutation_p.C28Y|NUDT16L1_ENST00000586252.1_Missense_Mutation_p.C28Y			Q9BRJ7	SDOS_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1	28						cytoplasm	hydrolase activity			endometrium(1)|large_intestine(1)|lung(1)|skin(1)	4						AGCCACTCGTGCCACGCCATG	0.706000													7	4					0	0	1	0	0
WDR5B	54554	broad.mit.edu	37	3	122133439	122133439	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:122133439C>T	ENST00000330689.4	-	1	1443	c.937G>A	c.(937-939)Gca>Aca	p.A313T		NM_019069.3	NP_061942.2	Q86VZ2	WDR5B_HUMAN	WD repeat domain 5B	313										kidney(2)|large_intestine(4)|lung(2)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	13				GBM - Glioblastoma multiforme(114;0.0704)		GCTGCTGATGCGATGAGGTTT	0.383000													29	42					0	0	1	0	0
SPAM1	0	broad.mit.edu	37	7	123594143	123594143	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:123594143G>A	ENST00000340011.5	+	3	876	c.519G>A	c.(517-519)caG>caA	p.Q173Q	SPAM1_ENST00000223028.7_Silent_p.Q173Q|SPAM1_ENST00000439500.1_Silent_p.Q173Q|SPAM1_ENST00000460182.1_Silent_p.Q173Q|SPAM1_ENST00000402183.2_Silent_p.Q173Q	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	173					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	AATTGGTTCAGCAACAAAATG	0.403000													21	30					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204434416	204434416	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:204434416C>T	ENST00000367187.3	-	4	1521	c.965G>A	c.(964-966)gGc>gAc	p.G322D	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.G322D	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	322					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			CAACTCATGGCCATTGGCAAC	0.517000													19	45					0	0	1	0	0
ANGEL2	90806	broad.mit.edu	37	1	213178540	213178540	+	Silent	SNP	C	C	T	rs148141428	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:213178540C>T	ENST00000366962.3	-	5	1123	c.969G>A	c.(967-969)acG>acA	p.T323T	ANGEL2_ENST00000535388.1_Silent_p.T154T|ANGEL2_ENST00000540642.1_Silent_p.T197T|ANGEL2_ENST00000360506.2_Silent_p.T154T|ANGEL2_ENST00000544555.1_Silent_p.T154T	NM_144567.3	NP_653168.2	Q5VTE6	ANGE2_HUMAN	angel homolog 2 (Drosophila)	323								p.T323T(1)		central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(1)	24				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		TTGCCAATTGCGTCAGCTTAA	0.458000													17	52					0	0	1	0	0
ZNF789	285989	broad.mit.edu	37	7	99084395	99084395	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99084395C>A	ENST00000331410.5	+	5	832	c.562C>A	c.(562-564)Ctt>Att	p.L188I	ZNF789_ENST00000448667.1_3'UTR|ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron	NM_213603.2	NP_998768.2	Q5FWF6	ZN789_HUMAN	zinc finger protein 789	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AAGATCTTTGCTTTTGGGGCA	0.418000													46	45					4.44401e-20	4.92268e-20	1	1	0
ANKFN1	162282	broad.mit.edu	37	17	54559800	54559800	+	Silent	SNP	C	C	T	rs146193202	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:54559800C>T	ENST00000566473.2	+	17	2184	c.2184C>T	c.(2182-2184)gaC>gaT	p.D728D	ANKFN1_ENST00000318698.2_Silent_p.D728D			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	728										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						CTGCCTCAGACGACGTCTGTA	0.512000													43	64					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872367	51872367	+	Silent	SNP	C	C	T	rs138612067		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:51872367C>T	ENST00000371497.5	+	2	3257	c.2370C>T	c.(2368-2370)caC>caT	p.H790H	TSHZ2_ENST00000329613.6_Silent_p.H787H|TSHZ2_ENST00000603338.2_Silent_p.H787H	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	790					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.H790H(1)		NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CTCAGAAGCACGCTCTGTCTG	0.557000													22	32					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67692587	67692587	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:67692587G>A	ENST00000335894.4	+	14	2107	c.2041G>A	c.(2041-2043)Gtg>Atg	p.V681M	IQCH_ENST00000358767.3_Missense_Mutation_p.V417M|IQCH_ENST00000360277.4_Missense_Mutation_p.V342M|IQCH_ENST00000546225.1_Missense_Mutation_p.V338M	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	681										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		CTACAAATGGGTGCTAAAGGA	0.448000													11	46					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004665	75004665	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:75004665C>T	ENST00000373359.2	-	1	414	c.222G>A	c.(220-222)gaG>gaA	p.E74E		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	74										autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GTCTGGACTGCTCGTCGATCA	0.562000													8	27					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61412650	61412650	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:61412650G>A	ENST00000395348.3	-	6	2046	c.1410C>T	c.(1408-1410)tgC>tgT	p.C470C	SLC16A9_ENST00000395347.1_Silent_p.C470C	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	470					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						CCAGCAGGACGCAGAAGCCAC	0.438000													22	33					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157771295	157771295	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:157771295G>A	ENST00000368176.3	-	6	1026	c.959C>T	c.(958-960)gCc>gTc	p.A320V	FCRL1_ENST00000489998.1_Intron|FCRL1_ENST00000358292.3_Intron|FCRL1_ENST00000491942.1_Missense_Mutation_p.A320V	NM_001159398.1|NM_052938.4	NP_001152870.1|NP_443170.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	320						integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GGCCACGGTGGCTGGACCAAG	0.458000													19	34					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71384050	71384050	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:71384050C>T	ENST00000392650.3	-	30	4319	c.4319G>A	c.(4318-4320)cGc>cAc	p.R1440H	SDK2_ENST00000388726.3_Missense_Mutation_p.R1440H	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1440	Fibronectin type-III 9.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GGGCAGCTCGCGGGTCTGGAT	0.647000													5	6					0	0	1	0	0
ABR	29	broad.mit.edu	37	17	916348	916348	+	Silent	SNP	G	G	A	rs141106809		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:916348G>A	ENST00000544583.2	-	17	2309	c.1710C>T	c.(1708-1710)aaC>aaT	p.N570N	ABR_ENST00000574437.1_Silent_p.N570N|ABR_ENST00000536794.2_Silent_p.N398N|ABR_ENST00000572441.1_Silent_p.N67N|ABR_ENST00000543210.2_Silent_p.N67N|ABR_ENST00000291107.2_Silent_p.N579N|ABR_ENST00000302538.5_Silent_p.N616N	NM_001159746.2	NP_001153218.1	Q12979	ABR_HUMAN	active BCR-related	616	C2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		GGCTCACCCCGTTCATCTCAA	0.642000													25	41					0	0	1	0	0
STOML1	9399	broad.mit.edu	37	15	74281124	74281124	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:74281124G>A	ENST00000316900.5	-	4	534	c.410C>T	c.(409-411)gCt>gTt	p.A137V	STOML1_ENST00000564777.1_Missense_Mutation_p.A87V|STOML1_ENST00000541638.1_Missense_Mutation_p.A95V|STOML1_ENST00000359750.4_Missense_Mutation_p.A137V|STOML1_ENST00000316911.6_Missense_Mutation_p.A87V|STOML1_ENST00000561656.1_Missense_Mutation_p.A50V	NM_001256672.1|NM_001256675.1|NM_001256677.1|NM_004809.4	NP_001243601.1|NP_001243604.1|NP_001243606.1|NP_004800.2	Q9UBI4	STML1_HUMAN	stomatin (EPB72)-like 1	137						integral to membrane	sterol binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						GGACAGCACAGCCCCGTCCTT	0.632000													15	38					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534794	92534794	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:92534794C>T	ENST00000298047.6	+	9	8632	c.8615C>T	c.(8614-8616)aCg>aTg	p.T2872M	FAT3_ENST00000409404.2_Missense_Mutation_p.T2872M|FAT3_ENST00000525166.1_Missense_Mutation_p.T2722M			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2872	Cadherin 26.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GACAGCAACACGGGCTGGATC	0.507000										TCGA Ovarian(4;0.039)			14	13					0	0	1	0	0
FAM129B	64855	broad.mit.edu	37	9	130286015	130286015	+	Missense_Mutation	SNP	C	C	A	rs144153796		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130286015C>A	ENST00000373312.3	-	5	745	c.532G>T	c.(532-534)Gcc>Tcc	p.A178S	FAM129B_ENST00000373314.3_Missense_Mutation_p.A165S|FAM129B_ENST00000468379.1_Intron	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	178	PH.						protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						TCCTGCTCGGCTTCTGTCATC	0.607000											OREG0019507	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	31					0.000442599	0.000451009	1	1	0
HEATR5A	25938	broad.mit.edu	37	14	31813196	31813196	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:31813196C>T	ENST00000543095.2	-	21	3318	c.3134G>A	c.(3133-3135)tGc>tAc	p.C1045Y	HEATR5A_ENST00000404677.3_Missense_Mutation_p.C1045Y|HEATR5A_ENST00000439727.1_Missense_Mutation_p.C752Y|HEATR5A_ENST00000389961.3_Missense_Mutation_p.C1039Y|HEATR5A_ENST00000439348.1_Missense_Mutation_p.C1039Y	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1039							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		TTGAACAAGGCAGTCTGGGTT	0.438000													10	17					0	0	1	0	0
C1orf194	127003	broad.mit.edu	37	1	109650563	109650563	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109650563C>T	ENST00000369949.4	-	2	321	c.142G>A	c.(142-144)Gcc>Acc	p.A48T	C1orf194_ENST00000369945.3_Intron|C1orf194_ENST00000369948.3_Missense_Mutation_p.A60T	NM_001122961.1	NP_001116433.1	Q5T5A4	CA194_HUMAN	chromosome 1 open reading frame 194	60										large_intestine(2)|lung(2)|ovary(2)	6						AAATAGTAGGCATCCCGCCTC	0.473000													17	19					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57829414	57829414	+	Silent	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:57829414A>T	ENST00000371030.2	+	5	4650	c.4650A>T	c.(4648-4650)ggA>ggT	p.G1550G		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1550						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CTTCATCTGGACAAAGAATTT	0.498000													7	10					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128979598	128979598	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:128979598G>A	ENST00000314797.6	+	12	1180	c.1076G>A	c.(1075-1077)cGc>cAc	p.R359H		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	359					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										AGCATCGACCGCCTCATGAAG	0.562000													13	27					0	0	1	0	0
SLC36A1	206358	broad.mit.edu	37	5	150867696	150867696	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150867696G>A	ENST00000243389.3	+	11	1535	c.1312G>A	c.(1312-1314)Gcc>Acc	p.A438T	SLC36A1_ENST00000520701.1_Missense_Mutation_p.A438T	NM_078483.2	NP_510968.2	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 1	438					cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			endometrium(5)|kidney(9)|lung(8)|skin(2)|urinary_tract(1)	25		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	CTTTAAGGACGCCCTGATCAG	0.582000													14	28					0	0	1	0	0
THNSL1	79896	broad.mit.edu	37	10	25312242	25312242	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:25312242G>A	ENST00000524413.1	+	3	437	c.90G>A	c.(88-90)caG>caA	p.Q30Q	THNSL1_ENST00000376356.4_Silent_p.Q30Q			Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1 (S. cerevisiae)	30					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(5)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	AACATGCACAGCGATTTCTTT	0.378000													29	32					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21114442	21114442	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:21114442C>T	ENST00000269228.5	-	23	4113	c.3559G>A	c.(3559-3561)Gcg>Acg	p.A1187T	NPC1_ENST00000412552.2_Missense_Mutation_p.A869T	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	1187					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GCCTCTTCCGCGCGCTCCACG	0.587000													15	19					0	0	1	0	0
G6PC	2538	broad.mit.edu	37	17	41056010	41056010	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41056010C>T	ENST00000253801.2	+	2	372	c.293C>T	c.(292-294)tCc>tTc	p.S98F	G6PC_ENST00000592383.1_Missense_Mutation_p.S98F|G6PC_ENST00000585489.1_Missense_Mutation_p.S98F	NM_000151.3	NP_000142.2	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	98					gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		AGCAACACTTCCGTGCCCCTG	0.493000													15	80					0	0	1	0	0
CHRNA6	8973	broad.mit.edu	37	8	42611543	42611543	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:42611543C>T	ENST00000276410.2	-	5	1154	c.799G>A	c.(799-801)Gac>Aac	p.D267N	CHRNA6_ENST00000534622.1_Missense_Mutation_p.D252N	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	267						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TCACCACAGTCCGAAGGAAGG	0.408000													11	25					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5021063	5021063	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:5021063C>T	ENST00000382545.3	+	2	1626	c.519C>T	c.(517-519)tcC>tcT	p.S173S	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	173					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CCATCGTCTCCGTCATGGTCA	0.627000													6	55					0	0	1	0	0
AC022007.5	0	broad.mit.edu	37	3	10050219	10050219	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:10050219C>T	ENST00000383808.2	-	0	559																											CTCAGCAGGGCGGGTTCCCAA	0.587000													15	11					0	0	1	0	0
NME7	29922	broad.mit.edu	37	1	169206902	169206902	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:169206902C>T	ENST00000367811.3	-	8	1034	c.778G>A	c.(778-780)Gct>Act	p.A260T	NME7_ENST00000472647.1_Missense_Mutation_p.A224T	NM_013330.3	NP_037462.1	Q9Y5B8	NDK7_HUMAN	NME/NM23 family member 7	260					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(8)|skin(1)	16	all_hematologic(923;0.208)					TCTCGGATAGCCATCAGGATC	0.303000													24	85					0	0	1	0	0
EIF3B	8662	broad.mit.edu	37	7	2409152	2409152	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2409152G>A	ENST00000360876.4	+	10	1505	c.1449G>A	c.(1447-1449)gtG>gtA	p.V483V	EIF3B_ENST00000397011.2_Silent_p.V483V	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	483					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CCTTCTGGGTGCCTGAAGACA	0.473000													5	209					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215813957	215813957	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:215813957G>A	ENST00000366943.2	-	68	15297	c.14911C>T	c.(14911-14913)Cga>Tga	p.R4971*	USH2A_ENST00000307340.3_Nonsense_Mutation_p.R4971*			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4971	Fibronectin type-III 35.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TACACGCGTCGCCCTCCGTCG	0.532000										HNSCC(13;0.011)			4	24					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114401162	114401162	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:114401162G>A	ENST00000359785.5	-	4	442	c.307C>T	c.(307-309)Cag>Tag	p.Q103*	PTPN22_ENST00000538253.1_5'UTR|AP4B1-AS1_ENST00000419536.1_RNA|PTPN22_ENST00000534519.1_5'UTR|PTPN22_ENST00000528414.1_Nonsense_Mutation_p.Q103*|PTPN22_ENST00000525799.1_Nonsense_Mutation_p.Q103*|PTPN22_ENST00000420377.2_Nonsense_Mutation_p.Q103*|PTPN22_ENST00000460620.1_Nonsense_Mutation_p.Q103*	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	103	Tyrosine-protein phosphatase.				negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAGGACCCTGGGTGGCAATA	0.438000													5	12					0	0	1	0	0
LDOC1L	84247	broad.mit.edu	37	22	44892885	44892885	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:44892885C>T	ENST00000341255.3	-	2	1061	c.552G>A	c.(550-552)gcG>gcA	p.A184A		NM_032287.2	NP_115663.2	Q6ICC9	LDOCL_HUMAN	leucine zipper, down-regulated in cancer 1-like	184										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(3)|prostate(2)	11		Ovarian(80;0.024)|all_neural(38;0.0416)		LUAD - Lung adenocarcinoma(64;0.0161)		GGGCGCGCCGCGCATGCCGGA	0.632000													5	6					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	161056553	161056553	+	Translation_Start_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:161056553G>T	ENST00000428609.2	-	0	210				ITGB6_ENST00000485635.1_Intron|ITGB6_ENST00000283249.2_Missense_Mutation_p.L8M|ITGB6_ENST00000409967.2_Missense_Mutation_p.L8M|ITGB6_ENST00000409872.1_Missense_Mutation_p.L8M			P18564	ITB6_HUMAN	integrin, beta 6						cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						AGAAAGAACAGGCAAAGCAGT	0.403000													11	26					6.40141e-05	6.5734e-05	1	1	0
STAB1	23166	broad.mit.edu	37	3	52557678	52557678	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52557678C>T	ENST00000321725.6	+	66	7377	c.7301C>T	c.(7300-7302)aCa>aTa	p.T2434I		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	2434	FAS1 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCCCCAGGGACAGTTGTGGTT	0.637000													7	16					0	0	1	0	0
ECT2	1894	broad.mit.edu	37	3	172480331	172480331	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:172480331T>C	ENST00000417960.1	+	9	1265	c.788T>C	c.(787-789)aTg>aCg	p.M263T	ECT2_ENST00000427830.1_Missense_Mutation_p.M264T|ECT2_ENST00000441497.2_Missense_Mutation_p.M264T|ECT2_ENST00000392692.3_Missense_Mutation_p.M295T|ECT2_ENST00000232458.5_Missense_Mutation_p.M264T|ECT2_ENST00000540509.1_Missense_Mutation_p.M295T	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	264	BRCT 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			ATGACTGAAATGCAAGGTAAA	0.299000													19	16					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62397734	62397734	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62397734G>A	ENST00000346178.4	-	14	1609	c.1594C>T	c.(1594-1596)Cct>Tct	p.P532S	GANAB_ENST00000534779.1_Missense_Mutation_p.P418S|GANAB_ENST00000356638.3_Missense_Mutation_p.P510S|GANAB_ENST00000540933.1_Missense_Mutation_p.P413S	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	510					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						GTGAAGTCAGGGTAACCAGCT	0.542000													7	10					0	0	1	0	0
CCDC110	256309	broad.mit.edu	37	4	186381043	186381043	+	Missense_Mutation	SNP	C	C	T	rs77987360	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:186381043C>T	ENST00000307588.3	-	6	773	c.698G>A	c.(697-699)gGa>gAa	p.G233E	CCDC110_ENST00000393540.3_Missense_Mutation_p.G196E|CCDC110_ENST00000510617.1_Missense_Mutation_p.G233E	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110	233						nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTCACAAAATCCATGCTTGAG	0.353000													24	27					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41536147	41536147	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:41536147C>T	ENST00000263253.7	+	9	2983	c.1764C>T	c.(1762-1764)gtC>gtT	p.V588V		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	588	KIX.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TTTCCAGCGTCCAAGCCATAT	0.373000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				30	55					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003519	57003519	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57003519G>C	ENST00000606794.1	-	1	1156	c.960C>G	c.(958-960)tgC>tgG	p.C320W		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	320						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						GCATGGAGGTGCAGGCCTGGC	0.617000													8	18					0	0	1	0	0
ZFP69	339559	broad.mit.edu	37	1	40961711	40961711	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:40961711G>A	ENST00000372706.1	+	6	2567	c.1561G>A	c.(1561-1563)Gcc>Acc	p.A521T	RP11-656D10.3_ENST00000450713.1_RNA|ZFP69_ENST00000372705.3_Missense_Mutation_p.A521T					ZFP69 zinc finger protein																		CAGGAGGAACGCCTTCCGAAA	0.368000													17	39					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13731575	13731575	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:13731575C>T	ENST00000383314.2	+	3	299	c.59C>T	c.(58-60)gCg>gTg	p.A20V	RNMT_ENST00000543302.2_Missense_Mutation_p.A20V|RNMT_ENST00000262173.3_Missense_Mutation_p.A20V|RNMT_ENST00000589866.1_Missense_Mutation_p.A20V|RNMT_ENST00000592764.1_Missense_Mutation_p.A20V|RNMT_ENST00000535051.1_Intron			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	20					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						CAGGCAAAAGCGTCAGTGAAT	0.363000													40	57					0	0	1	0	0
TNFRSF8	0	broad.mit.edu	37	1	12175745	12175745	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12175745C>A	ENST00000263932.2	+	8	1127	c.905C>A	c.(904-906)cCc>cAc	p.P302H	TNFRSF8_ENST00000417814.2_Missense_Mutation_p.P191H	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	302					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		CGCTGTGTCCCCTACCCAATC	0.617000													11	32					3.86212e-05	3.97146e-05	1	1	0
TKTL2	84076	broad.mit.edu	37	4	164394675	164394675	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:164394675C>T	ENST00000280605.3	-	1	372	c.212G>A	c.(211-213)cGg>cAg	p.R71Q		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	71						cytoplasm	metal ion binding|transketolase activity	p.R71Q(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GAGGATGAACCGGTCGTTGTC	0.542000													10	13					0	0	1	0	0
RFX5	5993	broad.mit.edu	37	1	151316303	151316303	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151316303G>A	ENST00000290524.4	-	9	789	c.611C>T	c.(610-612)gCg>gTg	p.A204V	RFX5_ENST00000452513.2_Missense_Mutation_p.A164V|RFX5_ENST00000452671.2_Missense_Mutation_p.A204V|RFX5_ENST00000368870.2_Missense_Mutation_p.A204V	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	204						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGGGCACACGCTGCCTCCAC	0.552000													18	36					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26898078	26898078	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26898078A>G	ENST00000374168.2	+	18	1883	c.1729A>G	c.(1729-1731)Aca>Gca	p.T577A	RPS6KA1_ENST00000526792.1_Missense_Mutation_p.T485A|RPS6KA1_ENST00000374162.2_Missense_Mutation_p.T485A|RPS6KA1_ENST00000374166.4_Missense_Mutation_p.T566A|RPS6KA1_ENST00000530003.1_Missense_Mutation_p.T561A|RPS6KA1_ENST00000531382.1_Missense_Mutation_p.T586A	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	577	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		ACCTTGCTACACAGCCAACTT	0.597000													6	16					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20799802	20799802	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:20799802C>T	ENST00000359062.3	+	12	2523	c.2483C>T	c.(2482-2484)gCg>gTg	p.A828V	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	828	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GAGTTGATGGCGCTGTATGTG	0.428000													28	73					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873427	91873427	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:91873427T>A	ENST00000373094.1	+	7	4377	c.3532T>A	c.(3532-3534)Tca>Aca	p.S1178T	PCDH11X_ENST00000373088.1_Missense_Mutation_p.S1141T|PCDH11X_ENST00000298274.8_Missense_Mutation_p.S1141T|PCDH11X_ENST00000373097.1_Missense_Mutation_p.S1168T|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000361655.2_Missense_Mutation_p.S1160T|PCDH11X_ENST00000406881.1_Missense_Mutation_p.S1170T	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1178					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CCCACCACTGTCACAGGCCTC	0.582000													28	4					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95481557	95481557	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95481557C>T	ENST00000356884.6	-	5	1437	c.1370G>A	c.(1369-1371)cGc>cAc	p.R457H	BICD2_ENST00000375512.3_Missense_Mutation_p.R457H	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	457					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						GTGCGTGCTGCGCAGTGCCTT	0.637000													19	20					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90344395	90344395	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:90344395G>A	ENST00000300060.6	-	12	2079	c.1766C>T	c.(1765-1767)aCa>aTa	p.T589I	ANPEP_ENST00000558177.1_5'UTR	NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	589	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TCTGATGGATGTGATGGGCAC	0.562000													4	80					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11123674	11123674	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11123674G>A	ENST00000358026.2	+	16	2608	c.2324G>A	c.(2323-2325)gGc>gAc	p.G775D	SMARCA4_ENST00000589677.1_Missense_Mutation_p.G775D|SMARCA4_ENST00000541122.2_Missense_Mutation_p.G775D|SMARCA4_ENST00000590574.1_Missense_Mutation_p.G775D|SMARCA4_ENST00000413806.3_Missense_Mutation_p.G775D|CTC-215O4.4_ENST00000587831.1_RNA|SMARCA4_ENST00000344626.4_Missense_Mutation_p.G775D|SMARCA4_ENST00000450717.3_Missense_Mutation_p.G775D|SMARCA4_ENST00000429416.3_Missense_Mutation_p.G775D|SMARCA4_ENST00000444061.3_Missense_Mutation_p.G775D	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	775	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AACCTGAACGGCATCCTGGCC	0.587000			"""F, N, Mis"""		NSCLC								8	18					0	0	1	0	0
KRT13	3860	broad.mit.edu	37	17	39658806	39658806	+	Missense_Mutation	SNP	C	C	T	rs148296285	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39658806C>T	ENST00000246635.3	-	6	1110	c.1064G>A	c.(1063-1065)cGc>cAc	p.R355H	KRT13_ENST00000587544.1_Missense_Mutation_p.R355H|KRT13_ENST00000336861.3_Missense_Mutation_p.R355H	NM_153490.2	NP_705694.2	P13646	K1C13_HUMAN	keratin 13	355	Coil 2.|Rod.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				CAGGGCATAGCGGCACTCCGT	0.602000													4	97					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48414814	48414814	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48414814C>T	ENST00000296438.5	+	3	293	c.107C>T	c.(106-108)gCa>gTa	p.A36V	FBXW12_ENST00000445170.1_Missense_Mutation_p.A17V|FBXW12_ENST00000415155.1_Missense_Mutation_p.A36V|FBXW12_ENST00000436231.1_Intron	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	36	F-box.									breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AATAGGATTGCAGACAGTGAT	0.502000													32	50					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90177027	90177027	+	Missense_Mutation	SNP	C	C	T	rs143915145		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:90177027C>T	ENST00000394412.3	-	12	2558	c.2482G>A	c.(2482-2484)Gtg>Atg	p.V828M		NM_198525.2	NP_940927.2	Q2M1P5	KIF7_HUMAN	kinesin family member 7	828					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	25	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			ATGAGCTGCACGTTCCGCTCG	0.647000													8	12					0	0	1	0	0
ACSL1	2180	broad.mit.edu	37	4	185687880	185687880	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:185687880G>A	ENST00000515030.1	-	13	1484	c.1159C>T	c.(1159-1161)Cga>Tga	p.R387*	ACSL1_ENST00000454703.2_Nonsense_Mutation_p.R216*|ACSL1_ENST00000504342.1_Nonsense_Mutation_p.R387*|ACSL1_ENST00000513317.1_Nonsense_Mutation_p.R387*|ACSL1_ENST00000507295.1_Nonsense_Mutation_p.R353*|ACSL1_ENST00000437665.3_Nonsense_Mutation_p.R216*|ACSL1_ENST00000281455.2_Nonsense_Mutation_p.R387*			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	387					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AAGAGCCATCGCTTCAGCGTG	0.488000													13	45					0	0	1	0	0
ZNF514	84874	broad.mit.edu	37	2	95818980	95818980	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:95818980C>T	ENST00000295208.2	-	3	481	c.19G>A	c.(19-21)Gct>Act	p.A7T	ZNF514_ENST00000411425.1_Missense_Mutation_p.A7T	NM_032788.1	NP_116177.1	Q96K75	ZN514_HUMAN	zinc finger protein 514	7	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(4)|lung(6)|urinary_tract(1)	11						AATTCCACAGCCACATCTTCA	0.478000													20	31					0	0	1	0	0
CSTF2T	23283	broad.mit.edu	37	10	53457674	53457674	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:53457674C>A	ENST00000331173.4	-	1	1681	c.1636G>T	c.(1636-1638)Gga>Tga	p.G546*	PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373980.4_Intron|PRKG1_ENST00000373985.1_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	546	9 X 5 AA tandem repeats of G-[AT]-G-[MI]- Q.|Gly-rich.				mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		tgtatacctcctccttgtata	0.547000													5	9					0.000602214	0.000612743	1	1	0
ACSL6	23305	broad.mit.edu	37	5	131323905	131323905	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:131323905C>T	ENST00000379264.2	-	7	775	c.667G>A	c.(667-669)Gtg>Atg	p.V223M	ACSL6_ENST00000379246.1_Missense_Mutation_p.V209M|ACSL6_ENST00000379272.2_Missense_Mutation_p.V213M|ACSL6_ENST00000379244.1_Missense_Mutation_p.V198M|ACSL6_ENST00000543479.1_Missense_Mutation_p.V198M|ACSL6_ENST00000544770.1_Missense_Mutation_p.V107M|ACSL6_ENST00000379255.1_Missense_Mutation_p.V163M|ACSL6_ENST00000431707.1_Missense_Mutation_p.V178M|ACSL6_ENST00000379249.3_Missense_Mutation_p.V198M|ACSL6_ENST00000379240.1_Missense_Mutation_p.V198M|ACSL6_ENST00000296869.4_Missense_Mutation_p.V223M|ACSL6_ENST00000357096.1_Missense_Mutation_p.V163M	NM_001009185.2	NP_001009185.1	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	198					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCCACAATCACGGTGCTGATG	0.582000													68	102					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80504231	80504231	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:80504231A>G	ENST00000265080.4	+	22	3197	c.3130A>G	c.(3130-3132)Atg>Gtg	p.M1044V	CTC-281B15.1_ENST00000503483.2_RNA	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	1044	Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TCCTTACATTATGAAAACCAG	0.403000													8	27					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105411299	105411299	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105411299C>T	ENST00000333244.5	-	7	10608	c.10489G>A	c.(10489-10491)Gat>Aat	p.D3497N	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3497						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCAGACACATCCAGCGAGGCC	0.607000													6	219					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118970052	118970052	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:118970052G>A	ENST00000515256.1	+	3	781	c.609G>A	c.(607-609)ctG>ctA	p.L203L				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	203						intracellular	zinc ion binding	p.L203L(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						CAGACAGCCTGCCAGGCTCAC	0.592000													4	51					0	0	1	0	0
CTDSPL	10217	broad.mit.edu	37	3	38012927	38012927	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38012927C>T	ENST00000443503.2	+	5	663	c.423C>T	c.(421-423)gaC>gaT	p.D141D	CTDSPL_ENST00000310189.3_3'UTR|CTDSPL_ENST00000273179.5_Silent_p.D152D	NM_005808.2	NP_005799.2	O15194	CTDSL_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	152	FCP1 homology.					nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|large_intestine(4)|skin(1)	8		Melanoma(1037;0.0122)		KIRC - Kidney renal clear cell carcinoma(284;0.0729)|Kidney(284;0.0902)		CACATGTGGACGAGTTCCTCC	0.597000													16	14					0	0	1	0	0
RFTN2	130132	broad.mit.edu	37	2	198511274	198511274	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:198511274C>T	ENST00000295049.3	-	2	792	c.256G>A	c.(256-258)Gtg>Atg	p.V86M		NM_144629.2	NP_653230.2	Q52LD8	RFTN2_HUMAN	raftlin family member 2	86						plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(13)|urinary_tract(3)	30						CGCTGCCCCACAGGTTGTATA	0.388000													68	125					0	0	1	0	0
INPP5A	3632	broad.mit.edu	37	10	134591246	134591246	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:134591246G>A	ENST00000368594.3	+	13	1326	c.1049G>A	c.(1048-1050)cGc>cAc	p.R350H	INPP5A_ENST00000368593.3_Missense_Mutation_p.R350H	NM_005539.3	NP_005530.3	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase, 40kDa	350					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			cervix(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		TGGTGTGACCGCATCCTCATG	0.652000													15	13					0	0	1	0	0
MOGS	7841	broad.mit.edu	37	2	74688821	74688821	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74688821G>A	ENST00000233616.4	-	4	2257	c.2095C>T	c.(2095-2097)Ctg>Ttg	p.L699L	MOGS_ENST00000452063.2_Silent_p.L593L|MOGS_ENST00000409065.1_3'UTR	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	699					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						AGCAGTCGCAGCAGCAAGGGA	0.622000													18	20					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031252	79031252	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:79031252A>G	ENST00000446378.2	+	2	6695	c.6664A>G	c.(6664-6666)Aca>Gca	p.T2222A		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2222						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TCCTGAAGGTACAATTCCCAC	0.393000													43	48					0	0	1	0	0
SYT14	255928	broad.mit.edu	37	1	210267703	210267703	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:210267703T>C	ENST00000537238.1	+	6	756	c.365T>C	c.(364-366)cTg>cCg	p.L122P	SYT14_ENST00000422431.1_Missense_Mutation_p.L205P|SYT14_ENST00000534859.1_Missense_Mutation_p.L160P|SYT14_ENST00000472886.1_Missense_Mutation_p.L160P|SYT14_ENST00000399639.2_Missense_Mutation_p.L160P|SYT14_ENST00000367015.1_Missense_Mutation_p.L122P|SYT14_ENST00000271745.7_3'UTR|SYT14_ENST00000367019.1_Missense_Mutation_p.L160P	NM_001256006.1|NM_153262.3	NP_001242935.1|NP_694994.2	Q8NB59	SYT14_HUMAN	synaptotagmin XIV	160						integral to membrane				endometrium(4)|large_intestine(11)|lung(17)|ovary(1)|prostate(1)|skin(3)	37				OV - Ovarian serous cystadenocarcinoma(81;0.085)		ACACCCCCGCTGGATGAATTG	0.438000													25	27					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139410012	139410012	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139410012C>A	ENST00000277541.6	-	11	1901	c.1826G>T	c.(1825-1827)aGc>aTc	p.S609I		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	609	EGF-like 16; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCAGGGCTGGCTGGAGCACTC	0.697000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			9	12					1.08611e-07	1.14056e-07	1	1	0
ROR2	4920	broad.mit.edu	37	9	94486292	94486292	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:94486292C>T	ENST00000375708.3	-	9	2682	c.2484G>A	c.(2482-2484)ccG>ccA	p.P828P	ROR2_ENST00000375715.1_Intron|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	828	Pro-rich.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CCCCATAGGCCGGCACCGGCT	0.657000													11	22					0	0	1	0	0
MAP3K1	4214	broad.mit.edu	37	5	56177976	56177976	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:56177976G>A	ENST00000399503.3	+	14	2949	c.2949G>A	c.(2947-2949)ttG>ttA	p.L983L		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	983					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		TTCCAGCCTTGTCAACCCCTT	0.458000													28	28					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214170503	214170503	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:214170503C>T	ENST00000366958.4	+	2	1233	c.625C>T	c.(625-627)Cgc>Tgc	p.R209C	PROX1_ENST00000498508.2_Missense_Mutation_p.R209C|PROX1_ENST00000435016.1_Missense_Mutation_p.R209C|PROX1_ENST00000261454.4_Missense_Mutation_p.R209C	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	209					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		AGAAAACAAACGCAAGCAAAA	0.517000													14	19					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55727937	55727937	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:55727937G>A	ENST00000379906.2	+	6	1189	c.934G>A	c.(934-936)Gca>Aca	p.A312T	SLC6A2_ENST00000568943.1_Missense_Mutation_p.A312T|SLC6A2_ENST00000566163.1_Missense_Mutation_p.A267T|SLC6A2_ENST00000567238.1_Missense_Mutation_p.A207T|SLC6A2_ENST00000219833.8_Missense_Mutation_p.A312T|SLC6A2_ENST00000414754.3_Missense_Mutation_p.A312T|SLC6A2_ENST00000561820.1_Missense_Mutation_p.A312T	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	312					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GATTGATGCCGCAACTCAGAT	0.453000													33	49					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178096565	178096565	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:178096565T>C	ENST00000397062.3	-	5	1320	c.766A>G	c.(766-768)Agc>Ggc	p.S256G	NFE2L2_ENST00000397063.4_Missense_Mutation_p.S240G|NFE2L2_ENST00000446151.2_Missense_Mutation_p.S233G|NFE2L2_ENST00000464747.1_Missense_Mutation_p.S240G	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	256					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			GAGAGGATGCTGCTGAAGGAA	0.373000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			27	42					0	0	1	0	0
ZNF853	54753	broad.mit.edu	37	7	6662232	6662232	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:6662232G>A	ENST00000457543.3	+	3	2168	c.1610G>A	c.(1609-1611)gGc>gAc	p.G537D		NM_017560.1	NP_060030.1	P0CG23	ZN853_HUMAN	zinc finger protein 853	537						intracellular	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)	2						ATCCACACGGGCGAGAAACCC	0.687000													4	1					0	0	1	0	0
CTNNA1	1495	broad.mit.edu	37	5	138118999	138118999	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:138118999C>T	ENST00000302763.7	+	3	329	c.239C>T	c.(238-240)gCg>gTg	p.A80V	CTNNA1_ENST00000518825.1_Missense_Mutation_p.A80V|CTNNA1_ENST00000355078.5_Intron	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	80	Involved in homodimerization.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GATAAAATTGCGAAGGAGAGC	0.453000													30	62					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44086637	44086637	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:44086637G>T	ENST00000359947.4	+	32	5833	c.5493G>T	c.(5491-5493)caG>caT	p.Q1831H	PTPRF_ENST00000372414.3_Missense_Mutation_p.Q1831H|PTPRF_ENST00000438120.1_Missense_Mutation_p.Q1822H|PTPRF_ENST00000372413.3_Missense_Mutation_p.Q1822H|PTPRF_ENST00000422171.2_Missense_Mutation_p.Q1190H|PTPRF_ENST00000496447.1_3'UTR	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1831	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGTTTGGACAGGATGGGCCTA	0.622000													11	15					3.86212e-05	3.97146e-05	1	1	0
MED15	51586	broad.mit.edu	37	22	20940935	20940935	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:20940935G>A	ENST00000263205.7	+	18	2380	c.2311G>A	c.(2311-2313)Gcc>Acc	p.A771T	MED15_ENST00000541476.1_Missense_Mutation_p.A705T|MED15_ENST00000425759.2_Missense_Mutation_p.A620T|MED15_ENST00000292733.7_Missense_Mutation_p.A731T|MED15_ENST00000382974.2_Missense_Mutation_p.A660T|MED15_ENST00000542773.1_3'UTR|MED15_ENST00000406969.1_Missense_Mutation_p.A705T	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	771					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			CTCGGTCACCGCCTTGCTCAA	0.672000													24	28					0	0	1	0	0
TCF23	150921	broad.mit.edu	37	2	27372993	27372993	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27372993C>T	ENST00000296096.5	+	2	355	c.225C>T	c.(223-225)agC>agT	p.S75S		NM_175769.2	NP_786951.1	Q7RTU1	TCF23_HUMAN	transcription factor 23	75					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus				large_intestine(2)|lung(11)|prostate(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGTGCAGAGCGAGGCCAGTC	0.657000													11	11					0	0	1	0	0
HSD3B1	3283	broad.mit.edu	37	1	120056532	120056532	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:120056532C>T	ENST00000235547.6	+	4	531	c.392C>T	c.(391-393)gCc>gTc	p.A131V	HSD3B1_ENST00000369413.3_Missense_Mutation_p.A129V|HSD3B1_ENST00000528909.1_Missense_Mutation_p.A129V	NM_000862.2	NP_000853.1	P14060	3BHS1_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	129					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(18)|ovary(2)|prostate(1)|skin(1)	32	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	ATAGAGGTAGCCGGGCCCAAC	0.512000													97	130					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149486411	149486411	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149486411C>T	ENST00000378016.2	+	0	4387							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGCCGATGGACGCTGCCTGCC	0.682000													8	16					0	0	1	0	0
TBC1D16	125058	broad.mit.edu	37	17	77914707	77914707	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:77914707C>T	ENST00000310924.2	-	12	2370	c.2255G>A	c.(2254-2256)gGc>gAc	p.G752D	TBC1D16_ENST00000340848.7_Missense_Mutation_p.G390D|TBC1D16_ENST00000576768.1_Missense_Mutation_p.G377D	NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	752						intracellular	Rab GTPase activator activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			GCCCTTCTTGCCTTCCCTCAG	0.687000													3	8					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3613607	3613607	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3613607G>A	ENST00000301749.7	-	0	1736				NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000603507.1_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CGATGCCAACGTCTCCTCTCT	0.572000													7	14					0	0	1	0	0
CTSL	1514	broad.mit.edu	37	9	90345356	90345356	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:90345356G>A	ENST00000343150.5	+	7	1735	c.845G>A	c.(844-846)gGc>gAc	p.G282D	CTSL_ENST00000340342.6_Missense_Mutation_p.G282D|CTSL_ENST00000495822.1_3'UTR					cathepsin L																		CTGGTGGTTGGCTACGGATTT	0.413000													19	34					0	0	1	0	0
MTHFD2	10797	broad.mit.edu	37	2	74441226	74441226	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74441226T>C	ENST00000394053.2	+	8	990	c.910T>C	c.(910-912)Tat>Cat	p.Y304H	MTHFD2_ENST00000264090.4_Missense_Mutation_p.Y202H|RP11-287D1.3_ENST00000451608.2_Intron|MTHFD2_ENST00000409601.1_Missense_Mutation_p.Y221H|MTHFD2_ENST00000394050.3_Missense_Mutation_p.Y140H|MTHFD2_ENST00000409804.1_Missense_Mutation_p.Y176H	NM_006636.3	NP_006627.2	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	304					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	AAAAGCTGGGTATATCACTCC	0.423000													46	76					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71384170	71384170	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:71384170G>A	ENST00000392650.3	-	30	4199	c.4199C>T	c.(4198-4200)cCg>cTg	p.P1400L	SDK2_ENST00000388726.3_Missense_Mutation_p.P1400L	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1400	Fibronectin type-III 9.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GGGGGGCTGCGGACGGTCTGG	0.687000													3	4					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3763443	3763443	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:3763443C>A	ENST00000440314.2	-	10	1454	c.981G>T	c.(979-981)caG>caT	p.Q327H	EFCAB4B_ENST00000444507.1_Missense_Mutation_p.Q327H|EFCAB4B_ENST00000252322.1_Missense_Mutation_p.Q327H	NM_001144958.1	NP_001138430.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	327					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			GCTGAGCATCCTGGAGCTCCC	0.552000													6	40					3.59834e-05	3.7043e-05	1	1	0
DMGDH	29958	broad.mit.edu	37	5	78329225	78329225	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:78329225G>A	ENST00000255189.3	-	8	1228	c.1200C>T	c.(1198-1200)ggC>ggT	p.G400G	DMGDH_ENST00000380311.4_Silent_p.G199G|DMGDH_ENST00000540686.1_Silent_p.G20G	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	400					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		CGTGGATTATGCCATATCTTT	0.388000													45	47					0	0	1	0	0
ZNF57	126295	broad.mit.edu	37	19	2917987	2917987	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2917987C>A	ENST00000306908.5	+	4	1516	c.1368C>A	c.(1366-1368)gcC>gcA	p.A456A	AC006277.2_ENST00000520090.2_RNA|ZNF57_ENST00000523428.1_Silent_p.A424A	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGGAAGGCCTTTACCTCTT	0.438000													26	49					2.48779e-11	2.67617e-11	1	1	0
NPDC1	56654	broad.mit.edu	37	9	139937391	139937391	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139937391G>A	ENST00000371600.3	-	1	1153	c.481C>T	c.(481-483)Cgc>Tgc	p.R161C	NPDC1_ENST00000488145.1_5'UTR|NPDC1_ENST00000371601.4_Missense_Mutation_p.R83C			Q9NQX5	NPDC1_HUMAN	neural proliferation, differentiation and control, 1	83	Pro/Ser/Thr-rich.					integral to membrane				NS(1)|large_intestine(1)|lung(1)|prostate(1)|urinary_tract(1)	5	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		GGAGGCCGGCGCATCCTGGGC	0.657000													8	17					0	0	1	0	0
AARS2	57505	broad.mit.edu	37	6	44272399	44272399	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:44272399C>T	ENST00000244571.4	-	12	1737	c.1735G>A	c.(1735-1737)Gtg>Atg	p.V579M	TMEM151B_ENST00000438774.2_Intron	NM_020745.3	NP_065796.1	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	579					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CCTGCCCGCACCAGGTAGCCA	0.632000											OREG0017473	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	30					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72171492	72171492	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:72171492A>T	ENST00000555818.1	+	13	4049	c.3701A>T	c.(3700-3702)gAa>gTa	p.E1234V	SIPA1L1_ENST00000358550.2_Intron|SIPA1L1_ENST00000554874.1_Intron|SIPA1L1_ENST00000381232.3_Intron|SIPA1L1_ENST00000537413.1_Intron	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1234					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GAGCAGCATGAATATACAGGT	0.398000													12	41					0	0	1	0	0
CLIP1	6249	broad.mit.edu	37	12	122803805	122803805	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:122803805G>A	ENST00000358808.2	-	17	3461	c.3307C>T	c.(3307-3309)Caa>Taa	p.Q1103*	CLIP1_ENST00000545889.1_Nonsense_Mutation_p.Q689*|CLIP1_ENST00000302528.7_Nonsense_Mutation_p.Q1103*|CLIP1_ENST00000540338.1_Nonsense_Mutation_p.Q1114*|CLIP1_ENST00000537178.1_Nonsense_Mutation_p.Q1068*|CLIP1_ENST00000361654.4_Nonsense_Mutation_p.Q992*	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	1114					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		GCATTTGTTTGCTTGGTGTCC	0.403000													20	34					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	26949206	26949206	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:26949206C>T	ENST00000539517.2	-	3	741	c.424G>A	c.(424-426)Gtt>Att	p.V142I	NOVA1_ENST00000465357.2_Missense_Mutation_p.V142I|NOVA1_ENST00000547619.1_Missense_Mutation_p.V142I|NOVA1_ENST00000344429.5_Missense_Mutation_p.V142I|NOVA1_ENST00000267422.7_Missense_Mutation_p.V20I|NOVA1_ENST00000574031.1_Missense_Mutation_p.V142I	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	145					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		TCTGGATTAACGGTGGTCTGG	0.398000													38	86					0	0	1	0	0
AP4M1	9179	broad.mit.edu	37	7	99704333	99704333	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99704333C>T	ENST00000429084.1	+	15	1369	c.1211C>T	c.(1210-1212)gCc>gTc	p.A404V	AP4M1_ENST00000422582.1_Missense_Mutation_p.A269V|AP4M1_ENST00000359593.4_Missense_Mutation_p.A397V|AP4M1_ENST00000421755.1_Missense_Mutation_p.A397V			O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	397	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCCACCTCGGCCTCTCCTCTG	0.672000													20	22					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81626555	81626555	+	Silent	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:81626555A>T	ENST00000356860.3	-	19	1940	c.1602T>A	c.(1600-1602)tcT>tcA	p.S534S	CACNA2D1_ENST00000356253.5_Silent_p.S553S	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	553	Cache.					voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTGGCTCCTGAGATTTGGGGT	0.343000													37	54					0	0	1	0	0
NPEPL1	79716	broad.mit.edu	37	20	57289700	57289700	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:57289700C>A	ENST00000356091.6	+	11	1675	c.1387C>A	c.(1387-1389)Ctg>Atg	p.L463M	STX16-NPEPL1_ENST00000530122.1_3'UTR|NPEPL1_ENST00000525817.1_Missense_Mutation_p.L415M|NPEPL1_ENST00000525967.1_Missense_Mutation_p.L435M	NM_024663.3	NP_078939.3	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	463					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			CTGGGTCCACCTGGACATTGC	0.657000													3	2					1	1	1	1	0
ROPN1B	152015	broad.mit.edu	37	3	125694467	125694467	+	Missense_Mutation	SNP	G	G	A	rs138282395	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:125694467G>A	ENST00000514116.1	+	4	493	c.178G>A	c.(178-180)Gct>Act	p.A60T	ROPN1B_ENST00000251776.4_Missense_Mutation_p.A60T|ROPN1B_ENST00000511082.1_5'UTR|ROPN1B_ENST00000505382.1_5'UTR			Q9BZX4	ROP1B_HUMAN	rhophilin associated tail protein 1B	60					acrosome reaction|cell-cell adhesion|cytokinesis|fusion of sperm to egg plasma membrane|Rho protein signal transduction|sperm motility|spermatogenesis	cytoplasm|flagellum	cAMP-dependent protein kinase regulator activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling complex scaffold activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|stomach(1)	8				GBM - Glioblastoma multiforme(114;0.151)		TGAGCGAGTCGCTTTGTGTAA	0.512000													13	21					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26562621	26562621	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:26562621C>T	ENST00000376261.3	+	11	1652	c.1149C>T	c.(1147-1149)ggC>ggT	p.G383G	GAD2_ENST00000259271.3_Silent_p.G383G	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	383					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	AACTGAGTGGCGTGGAGAGGT	0.383000													19	34					0	0	1	0	0
THOC7	80145	broad.mit.edu	37	3	63823673	63823673	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:63823673G>A	ENST00000295899.5	-	4	443	c.331C>T	c.(331-333)Cga>Tga	p.R111*	C3orf49_ENST00000295896.8_Intron|THOC7_ENST00000498422.1_5'UTR	NM_025075.2	NP_079351.2	Q6I9Y2	THOC7_HUMAN	THO complex 7 homolog (Drosophila)	111	Interaction with NIF3L1.|Interaction with THOC5.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	cytoplasm|THO complex part of transcription export complex	protein binding|RNA binding			central_nervous_system(1)|large_intestine(1)|ovary(1)|pancreas(1)	4				BRCA - Breast invasive adenocarcinoma(55;0.000439)|Kidney(15;0.00194)|KIRC - Kidney renal clear cell carcinoma(15;0.00218)		TTTCGTATTCGTTTTGCTTGA	0.333000													34	52					0	0	1	0	0
LRP3	4037	broad.mit.edu	37	19	33696659	33696659	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:33696659G>A	ENST00000253193.7	+	5	1185	c.983G>A	c.(982-984)cGc>cAc	p.R328H		NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	328	CUB 2.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					CTGTCCTACCGCAGCAACCAC	0.716000													4	3					0	0	1	0	0
IGLV11-55	0	broad.mit.edu	37	22	22556253	22556253	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:22556253C>T	ENST00000390286.2	+	0	79																											CCGGCCCGTGCTGACTCAGCC	0.607000											OREG0026354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	21					0	0	1	0	0
CNPY3	10695	broad.mit.edu	37	6	42905909	42905909	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:42905909C>A	ENST00000372836.4	+	5	948	c.577C>A	c.(577-579)Ctc>Atc	p.L193I	CNPY3_ENST00000394142.3_3'UTR	NM_006586.3	NP_006577.2	Q9BT09	CNPY3_HUMAN	canopy FGF signaling regulator 3	193	Saposin B-type.				innate immune response	endoplasmic reticulum				central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)	6	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			GACTGAATTCCTCTGCGCCAA	0.527000													31	38					5.91797e-21	6.56533e-21	1	1	0
CDH11	1009	broad.mit.edu	37	16	64984908	64984908	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:64984908G>A	ENST00000394156.3	-	12	2109	c.1656C>T	c.(1654-1656)ggC>ggT	p.G552G	CDH11_ENST00000566827.1_Silent_p.G426G|CDH11_ENST00000268603.4_Silent_p.G552G			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	552	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GGGCGTACACGCCTGCTGTGT	0.597000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			4	24					0	0	1	0	0
SLC9A1	6548	broad.mit.edu	37	1	27426937	27426937	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:27426937G>A	ENST00000263980.3	-	12	2884	c.2309C>T	c.(2308-2310)tCg>tTg	p.S770L	SLC9A1_ENST00000545949.1_Missense_Mutation_p.S431L	NM_003047.4	NP_003038.2	P19634	SL9A1_HUMAN	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	770					regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	TCCTGGGGACGAAGTCTCCTT	0.627000													33	57					0	0	1	0	0
MAP1S	55201	broad.mit.edu	37	19	17837219	17837219	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17837219C>T	ENST00000324096.4	+	5	1177	c.1026C>T	c.(1024-1026)tgC>tgT	p.C342C	MAP1S_ENST00000597681.1_Intron|MAP1S_ENST00000544059.2_Silent_p.C316C	NM_018174.4	NP_060644.4	Q66K74	MAP1S_HUMAN	microtubule-associated protein 1S	342	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	25						TCAACGCCTGCGAGGCCGCGT	0.731000													3	2					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43936214	43936214	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:43936214C>T	ENST00000262726.7	-	28	3925	c.3672G>A	c.(3670-3672)atG>atA	p.M1224I	EFCAB6_ENST00000396231.2_Missense_Mutation_p.M1072I|EFCAB6_ENST00000461800.1_5'UTR	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1224	EF-hand 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CATTGACTGGCATCTCGTTCC	0.572000													29	40					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56276416	56276416	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56276416C>T	ENST00000225371.5	+	8	1246	c.1136C>T	c.(1135-1137)aCg>aTg	p.T379M		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	379					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						ACCCGATCAACGGAAACCCCC	0.567000													4	49					0	0	1	0	0
ARHGEF37	389337	broad.mit.edu	37	5	149003654	149003654	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149003654G>A	ENST00000333677.6	+	10	1578	c.1415G>A	c.(1414-1416)cGc>cAc	p.R472H		NM_001001669.2	NP_001001669.2	A1IGU5	ARH37_HUMAN	Rho guanine nucleotide exchange factor (GEF) 37	472					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(5)|lung(6)|ovary(1)|prostate(2)|stomach(3)	17						AACCAGCTTCGCTCCTTTCAA	0.577000													9	29					0	0	1	0	0
LIMS1	3987	broad.mit.edu	37	2	109292448	109292448	+	Silent	SNP	C	C	T	rs111779374		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:109292448C>T	ENST00000393310.1	+	6	776	c.609C>T	c.(607-609)cgC>cgT	p.R203R	LIMS1_ENST00000544547.1_Silent_p.R215R|LIMS1_ENST00000338045.3_Silent_p.R203R|LIMS1_ENST00000409441.1_Silent_p.R240R|LIMS1_ENST00000410093.1_Silent_p.R207R|LIMS1_ENST00000542845.1_Silent_p.R265R|LIMS1_ENST00000332345.6_Silent_p.R203R	NM_001193488.1	NP_001180417.1	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	203	LIM zinc-binding 4.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	10						TCGAAGGGCGCGTGGTGAACG	0.537000													6	9					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39433688	39433688	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:39433688G>A	ENST00000280481.7	+	14	7696	c.7480G>A	c.(7480-7482)Gag>Aag	p.E2494K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2494					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGAAGGCCTGGAGCTCATGAG	0.493000													9	19					0	0	1	0	0
SOCS4	122809	broad.mit.edu	37	14	55510444	55510444	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:55510444G>A	ENST00000395472.2	+	2	1017	c.685G>A	c.(685-687)Gat>Aat	p.D229N	SOCS4_ENST00000555846.1_Missense_Mutation_p.D229N|SOCS4_ENST00000339298.2_Missense_Mutation_p.D229N	NM_080867.2|NM_199421.1	NP_543143.1|NP_955453.1	Q8WXH5	SOCS4_HUMAN	suppressor of cytokine signaling 4	229					intracellular signal transduction|negative regulation of signal transduction|regulation of growth					central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	14						TAGTGATATGGATTCCGATGA	0.403000													28	44					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141135848	141135848	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:141135848C>A	ENST00000389484.3	-	68	11510	c.10539G>T	c.(10537-10539)caG>caT	p.Q3513H		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3513					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGTACATGTCTGTGGCTCTG	0.383000										TSP Lung(27;0.18)			21	30					2.37509e-13	2.57931e-13	1	1	0
FREM2	341640	broad.mit.edu	37	13	39263301	39263301	+	Missense_Mutation	SNP	C	C	T	rs115928688	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:39263301C>T	ENST00000280481.7	+	1	2036	c.1820C>T	c.(1819-1821)aCg>aTg	p.T607M		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	607					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TTCTTAACTACGGGGCATCTG	0.527000													25	28					0	0	1	0	0
FSCN2	25794	broad.mit.edu	37	17	79496288	79496288	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79496288C>T	ENST00000417245.2	+	1	867	c.731C>T	c.(730-732)aCg>aTg	p.T244M	FSCN2_ENST00000334850.7_Missense_Mutation_p.T244M	NM_001077182.2|NM_012418.3	NP_001070650.1|NP_036550.1	O14926	FSCN2_HUMAN	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	244					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging			endometrium(1)|lung(1)|prostate(1)|urinary_tract(1)	4	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GGCCGAAACACGCGACCTGGC	0.647000													8	10					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64085073	64085073	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:64085073C>T	ENST00000295902.6	-	8	2774	c.2189G>A	c.(2188-2190)cGg>cAg	p.R730Q	RP11-129B22.1_ENST00000482609.1_RNA|PRICKLE2_ENST00000564377.1_Missense_Mutation_p.R786Q|PRICKLE2-AS1_ENST00000476308.1_RNA	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	730	Arg-rich.					cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CTGGAAGCTCCGCTGGCGCAT	0.617000													8	35					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54786925	54786925	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:54786925T>C	ENST00000545554.1	+	19	5053	c.5053T>C	c.(5053-5055)Tac>Cac	p.Y1685H	UNC13C_ENST00000260323.11_Missense_Mutation_p.Y1685H|UNC13C_ENST00000537900.1_Missense_Mutation_p.Y1683H			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1685	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGTTCCTGAATACTCCTTGTA	0.353000													42	53					0	0	1	0	0
CHAC1	79094	broad.mit.edu	37	15	41247791	41247791	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:41247791C>T	ENST00000446533.3	+	3	923	c.614C>T	c.(613-615)aCg>aTg	p.T205M	CHAC1_ENST00000444189.2_Missense_Mutation_p.T160M|CHAC1_ENST00000487220.1_5'UTR	NM_001142776.1|NM_024111.3	NP_001136248.1|NP_077016.2	Q9BUX1	CHAC1_HUMAN	ChaC, cation transport regulator homolog 1 (E. coli)	205					apoptosis in response to endoplasmic reticulum stress|response to unfolded protein	cytosol	protein binding			endometrium(1)|large_intestine(1)|skin(1)	3		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.66e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GCCATTGCCACGCAGATCCTG	0.622000													15	108					0	0	1	0	0
AXIN1	8312	broad.mit.edu	37	16	354308	354308	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:354308C>T	ENST00000262320.3	-	5	1621	c.1250G>A	c.(1249-1251)cGc>cAc	p.R417H	AXIN1_ENST00000354866.3_Missense_Mutation_p.R417H|AXIN1_ENST00000481769.1_5'UTR	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	417	Interaction with GSK3B (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding	p.?(1)		biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				ACTCACCATGCGCACGCGCTT	0.677000													16	12					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153914384	153914384	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:153914384C>T	ENST00000361217.4	-	6	1434	c.1016G>A	c.(1015-1017)cGc>cAc	p.R339H		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	339	DENN.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GACGGAGTAGCGGTAAAGGAA	0.657000													12	22					0	0	1	0	0
ARHGAP44	9912	broad.mit.edu	37	17	12846944	12846944	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:12846944A>G	ENST00000379672.5	+	9	991	c.691A>G	c.(691-693)Aca>Gca	p.T231A	ARHGAP44_ENST00000262444.9_Missense_Mutation_p.T231A|ARHGAP44_ENST00000340825.3_Missense_Mutation_p.T231A	NM_014859.4	NP_055674.4	Q17R89	RHG44_HUMAN	Rho GTPase activating protein 44	231	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|urinary_tract(1)	31						GAAGTCCCTGACACTATTGCA	0.557000													4	83					0	0	1	0	0
DLD	1738	broad.mit.edu	37	7	107545875	107545875	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:107545875G>A	ENST00000205402.5	+	7	789	c.508G>A	c.(508-510)Ggc>Agc	p.G170S	DLD_ENST00000537148.1_Missense_Mutation_p.G71S|DLD_ENST00000437604.2_Intron|DLD_ENST00000440410.1_Missense_Mutation_p.G147S	NM_000108.3	NP_000099.2	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase	170					branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(10)|prostate(1)	20					NADH(DB00157)	AGCTGATGGCGGCACTCAGGT	0.358000													44	62					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17410236	17410236	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:17410236G>A	ENST00000375486.4	-	9	1098	c.1035C>T	c.(1033-1035)ggC>ggT	p.G345G	PADI2_ENST00000444885.2_Silent_p.G229G|PADI2_ENST00000375481.1_Silent_p.G345G	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	345					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TCCAGCGATCGCCTCGGTTTA	0.532000													33	37					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197091131	197091131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:197091131C>T	ENST00000367409.4	-	16	4040	c.3784G>A	c.(3784-3786)Gat>Aat	p.D1262N	ASPM_ENST00000367408.1_Missense_Mutation_p.D512N|ASPM_ENST00000294732.7_Missense_Mutation_p.D1262N	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1262					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TTACGAAGATCCAAAAGCCTT	0.333000													21	25					0	0	1	0	0
IL2RB	0	broad.mit.edu	37	22	37539572	37539572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37539572C>T	ENST00000216223.5	-	3	390	c.192G>A	c.(190-192)tgG>tgA	p.W64*		NM_000878.3	NP_000869.1	P14784	IL2RB_HUMAN	interleukin 2 receptor, beta	64					interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(5)	23					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GTCTGTCCGGCCAGGCATGGA	0.537000													8	13					0	0	1	0	0
PABPC5	140886	broad.mit.edu	37	X	90690630	90690630	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:90690630C>T	ENST00000312600.3	+	2	268	c.54C>T	c.(52-54)gcC>gcT	p.A18A	PABPC5_ENST00000373105.1_Intron	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	18	RRM 1.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						ATCTCAAGGCCGCTCTGTACG	0.542000													11	3					0	0	1	0	0
NEO1	4756	broad.mit.edu	37	15	73541550	73541550	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:73541550G>A	ENST00000339362.5	+	11	2202		c.e11+1		NEO1_ENST00000261908.6_Splice_Site|NEO1_ENST00000560262.1_Splice_Site|NEO1_ENST00000560352.1_Splice_Site|NEO1_ENST00000558964.1_Splice_Site			Q92859	NEO1_HUMAN	neogenin 1						axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						TAAAGAACAGGTATGAAGTGA	0.383000													21	18					0	0	1	0	0
ENTHD1	150350	broad.mit.edu	37	22	40257913	40257913	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:40257913C>T	ENST00000325157.6	-	3	699	c.449G>A	c.(448-450)cGt>cAt	p.R150H		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	150										breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					GTGGGAGGTACGCTGTCTAGT	0.448000													22	34					0	0	1	0	0
ZNF746	155061	broad.mit.edu	37	7	149174839	149174839	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149174839C>T	ENST00000340622.3	-	5	808	c.528G>A	c.(526-528)ggG>ggA	p.G176G	ZNF746_ENST00000458143.2_Silent_p.G176G			Q6NUN9	ZN746_HUMAN	zinc finger protein 746	176					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GAACTGGGGGCCCCGAGCCTA	0.657000													11	13					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	104034652	104034652	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:104034652G>A	ENST00000302251.5	-	1	455	c.4C>T	c.(4-6)Cac>Tac	p.H2Y	PDGFD_ENST00000393158.2_Missense_Mutation_p.H2Y	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	2					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		ATGAGCCGGTGCATTTGGGAT	0.602000											OREG0021315	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	21					0	0	1	0	0
AGPAT2	10555	broad.mit.edu	37	9	139571064	139571064	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139571064G>A	ENST00000371696.2	-	4	626	c.561C>T	c.(559-561)ggC>ggT	p.G187G	AGPAT2_ENST00000371694.3_Intron|AGPAT2_ENST00000538402.1_Silent_p.G187G	NM_006412.3	NP_006403.2	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	187					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity	p.G187G(2)		endometrium(1)|large_intestine(1)|lung(2)|prostate(2)	6	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		GGTAGAAGGCGCCCTTCTTAA	0.627000													28	29					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58123441	58123441	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:58123441G>A	ENST00000257897.3	-	13	1615	c.1530C>T	c.(1528-1530)ggC>ggT	p.G510G	AGAP2_ENST00000547588.1_Silent_p.G846G	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	846	G domain.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						GCCCAGCCGAGCCTTCAGTCT	0.587000													30	54					0	0	1	0	0
PDE4A	5141	broad.mit.edu	37	19	10578164	10578164	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10578164C>T	ENST00000380702.2	+	16	2462	c.2462C>T	c.(2461-2463)gCg>gTg	p.A821V	PDE4A_ENST00000592685.1_Missense_Mutation_p.A821V|PDE4A_ENST00000352831.6_Missense_Mutation_p.A843V|PDE4A_ENST00000293683.5_Missense_Mutation_p.A817V|PDE4A_ENST00000440014.2_Missense_Mutation_p.A782V|PDE4A_ENST00000344979.3_Missense_Mutation_p.A604V			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	843					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CCCTCCACGGCGGCCGAGGTG	0.672000													47	40					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10097008	10097008	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10097008C>A	ENST00000264828.3	-	30	2420	c.2335G>T	c.(2335-2337)Ggc>Tgc	p.G779C		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	779	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CCAGCTGAGCCTGGGGGCCCC	0.622000													8	11					0.0381472	0.0383569	1	1	0
ZNF418	147686	broad.mit.edu	37	19	58437963	58437963	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58437963C>T	ENST00000396147.1	-	4	1877	c.1586G>A	c.(1585-1587)cGg>cAg	p.R529Q	ZNF418_ENST00000600989.1_Intron|ZNF418_ENST00000599852.1_Missense_Mutation_p.R444Q|ZNF418_ENST00000425570.3_Missense_Mutation_p.R550Q|ZNF418_ENST00000595830.1_Missense_Mutation_p.R529Q	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	529					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		ATGAACTCTCCGATGTCGAAG	0.453000													25	83					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105203743	105203743	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:105203743C>T	ENST00000369797.3	+	34	5290	c.5196C>T	c.(5194-5196)ggC>ggT	p.G1732G		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	1732					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TCAAATACGGCGCCTTCCTTC	0.602000													8	75					0	0	1	0	0
FBP2	8789	broad.mit.edu	37	9	97349726	97349726	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:97349726C>T	ENST00000375337.3	-	2	262	c.196G>A	c.(196-198)Gtg>Atg	p.V66M		NM_003837.2	NP_003828.2	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	66					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding			endometrium(1)|large_intestine(3)|lung(5)	9		Acute lymphoblastic leukemia(62;0.136)				TCTCCCGTCACGTTAACGCTT	0.493000													13	95					0	0	1	0	0
PKN1	5585	broad.mit.edu	37	19	14574936	14574936	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:14574936C>T	ENST00000242783.6	+	12	1867	c.1702C>T	c.(1702-1704)Cgg>Tgg	p.R568W	PKN1_ENST00000342216.4_Missense_Mutation_p.R574W	NM_002741.3	NP_002732.3	Q16512	PKN1_HUMAN	protein kinase N1	568					activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)	31						GAAGAGCTCGCGGGATCCTCC	0.637000													14	31					0	0	1	0	0
HECA	51696	broad.mit.edu	37	6	139488332	139488332	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:139488332G>A	ENST00000367658.2	+	2	1468	c.1183G>A	c.(1183-1185)Gtg>Atg	p.V395M	RP1-225E12.2_ENST00000415194.2_RNA|RP1-225E12.2_ENST00000589192.1_RNA|RP1-225E12.2_ENST00000586229.1_RNA|RP1-225E12.2_ENST00000586266.1_RNA|RP1-225E12.2_ENST00000590679.1_RNA|RP1-225E12.2_ENST00000588638.1_RNA|RP1-225E12.2_ENST00000587577.1_RNA|RP1-225E12.2_ENST00000588529.1_RNA|RP1-225E12.3_ENST00000585874.1_RNA	NM_016217.2	NP_057301.1	Q9UBI9	HDC_HUMAN	headcase homolog (Drosophila)	395					respiratory tube development					endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)	15				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		CCACAGAAACGTGGTAAACTG	0.577000													11	19					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74648336	74648336	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:74648336C>T	ENST00000354431.4	-	3	650	c.459G>A	c.(457-459)gcG>gcA	p.A153A	LRRIQ3_ENST00000395089.1_Silent_p.A153A|LRRIQ3_ENST00000370911.3_Silent_p.A153A|LRRIQ3_ENST00000370909.2_Intron	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	153	LRRCT.									NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						GATGATCCAGCGCTTTGAGAG	0.388000													21	34					0	0	1	0	0
PFKP	5214	broad.mit.edu	37	10	3146002	3146002	+	Silent	SNP	C	C	T	rs143826212	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:3146002C>T	ENST00000381075.2	+	7	686	c.462C>T	c.(460-462)taC>taT	p.Y154Y	PFKP_ENST00000381125.4_Silent_p.Y162Y	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	162					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		TGCAGAAGTACGCCTACCTCA	0.627000													11	24					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56648724	56648724	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:56648724A>G	ENST00000336078.4	+	10	4062	c.3286A>G	c.(3286-3288)Acc>Gcc	p.T1096A	ZNF532_ENST00000591808.1_Missense_Mutation_p.T1096A|ZNF532_ENST00000591083.1_Missense_Mutation_p.T1096A|ZNF532_ENST00000588956.1_3'UTR|ZNF532_ENST00000589288.1_Missense_Mutation_p.T1096A|ZNF532_ENST00000591230.1_Missense_Mutation_p.T1096A	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1096					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						CTCCAGACGTACCTTTACCAA	0.517000													8	120					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42038144	42038144	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:42038144C>T	ENST00000220809.4	-	10	1205	c.949G>A	c.(949-951)Gcc>Acc	p.A317T	PLAT_ENST00000352041.3_Missense_Mutation_p.A271T|PLAT_ENST00000429710.2_Missense_Mutation_p.A191T|PLAT_ENST00000429089.2_Missense_Mutation_p.A317T|PLAT_ENST00000524009.1_Missense_Mutation_p.A228T|PLAT_ENST00000519510.1_Missense_Mutation_p.A254T|PLAT_ENST00000270189.6_Intron	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	317	Peptidase S1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GCGATGTCGGCGAAGAGCCCT	0.642000													16	22					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424125	56424125	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56424125A>G	ENST00000588751.1	-	5	1082	c.1058T>C	c.(1057-1059)tTg>tCg	p.L353S	NLRP13_ENST00000342929.3_Missense_Mutation_p.L353S			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	353	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAGGGGAACCAATTCTTTCTT	0.473000													32	67					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128294914	128294914	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:128294914C>T	ENST00000368227.3	-	29	4445	c.4079G>A	c.(4078-4080)cGa>cAa	p.R1360Q	PTPRK_ENST00000532331.1_Missense_Mutation_p.R1365Q|PTPRK_ENST00000368207.3_Missense_Mutation_p.R1375Q|PTPRK_ENST00000368226.4_Missense_Mutation_p.R1343Q|PTPRK_ENST00000368215.3_Missense_Mutation_p.R1342Q|PTPRK_ENST00000368213.5_Missense_Mutation_p.R1349Q|PTPRK_ENST00000368210.3_Missense_Mutation_p.R1361Q			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1342	Tyrosine-protein phosphatase 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		AGGCACTTCTCGATGAGAAGC	0.478000													50	58					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27454973	27454973	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27454973T>C	ENST00000264705.4	+	17	2688	c.2526T>C	c.(2524-2526)cgT>cgC	p.R842R	CAD_ENST00000464159.1_3'UTR|CAD_ENST00000403525.1_Silent_p.R779R	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	842	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GAATGAAGCGTATCATCGCAC	0.552000													12	60					0	0	1	0	0
PTBP1	5725	broad.mit.edu	37	19	804675	804675	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:804675C>T	ENST00000356948.6	+	6	1002	c.579C>T	c.(577-579)taC>taT	p.Y193Y	PTBP1_ENST00000394601.4_Silent_p.Y193Y|PTBP1_ENST00000350092.4_Intron|PTBP1_ENST00000349038.4_Silent_p.Y193Y	NM_002819.4	NP_002810.1	P26599	PTBP1_HUMAN	polypyrimidine tract binding protein 1	193	RRM 2.				negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)	19		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTCTTCTACCCTGTGACCC	0.677000													4	42					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35449581	35449581	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35449581G>A	ENST00000404801.1	-	4	1564	c.1178C>T	c.(1177-1179)gCc>gTc	p.A393V	ZNF792_ENST00000605484.1_Missense_Mutation_p.A326V	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCACTCATGGGCACTTCTGCC	0.463000													5	36					0	0	1	0	0
ZNF846	162993	broad.mit.edu	37	19	9872823	9872823	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9872823C>T	ENST00000397902.2	-	4	577	c.164G>A	c.(163-165)cGt>cAt	p.R55H	ZNF846_ENST00000592859.1_Intron|ZNF846_ENST00000586293.1_Missense_Mutation_p.R55H|ZNF846_ENST00000588267.1_5'UTR	NM_001077624.1	NP_001071092.1	Q147U1	ZN846_HUMAN	zinc finger protein 846	55	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22						CATGAGACTACGTTTGAATAA	0.453000													36	79					0	0	1	0	0
PBK	55872	broad.mit.edu	37	8	27678146	27678146	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:27678146G>A	ENST00000301905.4	-	6	994	c.531C>T	c.(529-531)ggC>ggT	p.G177G	PBK_ENST00000522944.1_Silent_p.G177G	NM_018492.2	NP_060962.2	Q96KB5	TOPK_HUMAN	PDZ binding kinase	177	Protein kinase.				mitosis		ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(1)|large_intestine(2)|lung(1)	4		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|KIRC - Kidney renal clear cell carcinoma(542;0.101)|Kidney(114;0.121)|Colorectal(74;0.141)		TTTCAAAATCGCCTTTAATTA	0.299000													42	85					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52201708	52201708	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:52201708C>T	ENST00000282588.6	+	12	1883	c.1425C>T	c.(1423-1425)atC>atT	p.I475I		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	475					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				ATGGAAACATCAAAATTCTCC	0.368000													52	85					0	0	1	0	0
CAPZB	832	broad.mit.edu	37	1	19775361	19775361	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:19775361G>A	ENST00000264203.3	-	2	541	c.48C>T	c.(46-48)ggC>ggT	p.G16G	CAPZB_ENST00000375142.1_Intron|CAPZB_ENST00000401084.2_Intron|CAPZB_ENST00000264202.6_Intron|CAPZB_ENST00000482808.1_Intron|CAPZB_ENST00000433834.1_Intron			P47756	CAPZB_HUMAN	capping protein (actin filament) muscle Z-line, beta	0					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement	cytosol|F-actin capping protein complex|WASH complex	actin binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	7		Colorectal(325;3.93e-05)|Renal(390;0.000147)|all_lung(284;0.000169)|Lung NSC(340;0.000202)|Breast(348;0.000496)|Ovarian(437;0.00428)|Myeloproliferative disorder(586;0.0262)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Kidney(64;8.63e-06)|BRCA - Breast invasive adenocarcinoma(304;4.06e-05)|KIRC - Kidney renal clear cell carcinoma(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000525)|STAD - Stomach adenocarcinoma(196;0.00779)|READ - Rectum adenocarcinoma(331;0.103)|Lung(427;0.173)		TTCTGGGCTGGCCAAGGCCTG	0.572000													11	14					0	0	1	0	0
CRAT	1384	broad.mit.edu	37	9	131862813	131862813	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131862813G>A	ENST00000318080.2	-	7	1255	c.961C>T	c.(961-963)Cgc>Tgc	p.R321C		NM_000755.3|NM_001257363.1	NP_000746.2|NP_001244292.1	P43155	CACP_HUMAN	carnitine O-acetyltransferase	321					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	TCGAACCAGCGGTTGCCGCTG	0.652000													13	20					0	0	1	0	0
GRM8	0	broad.mit.edu	37	7	126746587	126746587	+	Silent	SNP	G	G	A	rs146491203		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:126746587G>A	ENST00000339582.2	-	3	1498	c.690C>T	c.(688-690)agC>agT	p.S230S	GRM8_ENST00000358373.3_Silent_p.S230S|GRM8_ENST00000444921.2_Silent_p.S230S|GRM8_ENST00000405249.1_Silent_p.S230S|GRM8_ENST00000480995.1_5'UTR			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	230					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCTCCACACCGCTCTCACCAT	0.502000										HNSCC(24;0.065)			7	14					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120996289	120996289	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:120996289C>T	ENST00000392793.1	+	8	1753	c.1482C>T	c.(1480-1482)caC>caT	p.H494H	TECTA_ENST00000264037.2_Silent_p.H494H			O75443	TECTA_HUMAN	tectorin alpha	494	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GTGTGTACCACGCAGACTGGA	0.587000													36	47					0	0	1	0	0
FAM210A	125228	broad.mit.edu	37	18	13666632	13666632	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:13666632C>T	ENST00000322247.3	-	5	1053	c.666G>A	c.(664-666)atG>atA	p.M222I	FAM210A_ENST00000588475.1_5'UTR|FAM210A_ENST00000402563.1_Missense_Mutation_p.M222I	NM_001098801.1	NP_001092271.1	Q96ND0	CR019_HUMAN	family with sequence similarity 210, member A	222	DUF1279.					integral to membrane											GCGGCGTGGACATGTAGCCAT	0.473000													8	25					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123966145	123966145	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:123966145G>A	ENST00000314393.4	+	3	3230	c.2395G>A	c.(2395-2397)Ggg>Agg	p.G799R		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	799						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GGTGACGGTCGGGGAGGAGGA	0.617000													8	13					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1481957	1481957	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:1481957C>T	ENST00000297508.7	-	7	1757	c.1582G>A	c.(1582-1584)Gca>Aca	p.A528T	MICALL2_ENST00000405088.4_Missense_Mutation_p.A316T	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	528						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		AACGCGGATGCCTGAGAGGTA	0.677000													31	38					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67108324	67108324	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:67108324C>T	ENST00000284425.2	-	16	2306	c.2132_splice	c.e16+1	p.S711_splice		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	711	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					AAGTCTTTACCTTAGGTGATA	0.383000													64	93					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43597968	43597968	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:43597968C>A	ENST00000355710.3	+	3	748	c.516C>A	c.(514-516)ccC>ccA	p.P172P	RET_ENST00000340058.5_Silent_p.P172P	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	172	Cadherin.				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	AGACAAGGCCCTCCTTCCGCA	0.627000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				8	16					0.00307968	0.00311927	1	1	0
PIGR	5284	broad.mit.edu	37	1	207106341	207106341	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:207106341C>T	ENST00000356495.4	-	7	2059	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	626						extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTGCCGGAATCCACAGATGCT	0.562000													13	53					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79749053	79749053	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:79749053C>T	ENST00000305428.3	+	2	639	c.564C>T	c.(562-564)cgC>cgT	p.R188R		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	188						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						TGAAAAACCGCGCCGCTTCCC	0.572000													16	24					0	0	1	0	0
ILK	3611	broad.mit.edu	37	11	6631830	6631830	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6631830G>A	ENST00000396751.2	+	12	1803	c.1347G>A	c.(1345-1347)atG>atA	p.M449I	ILK_ENST00000299421.4_Missense_Mutation_p.M449I|ILK_ENST00000537806.1_Missense_Mutation_p.M315I|ILK_ENST00000420936.2_Missense_Mutation_p.M449I|ILK_ENST00000528995.1_Missense_Mutation_p.M388I	NM_001014795.1	NP_001014795.1	Q13418	ILK_HUMAN	integrin-linked kinase	449					cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		TTGAGAAGATGCAGGACAAGT	0.512000													22	33					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12303922	12303922	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:12303922C>T	ENST00000261349.4	-	13	2918	c.2842G>A	c.(2842-2844)Gtg>Atg	p.V948M	LRP6_ENST00000543091.1_Missense_Mutation_p.V948M	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	948	Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				TCATCAATCACCATGCGGTTG	0.468000													17	29					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111398967	111398967	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:111398967T>C	ENST00000535254.1	-	21	2707	c.2640A>G	c.(2638-2640)agA>agG	p.R880R	BUB1_ENST00000478175.1_5'UTR|BUB1_ENST00000302759.6_Silent_p.R900R|BUB1_ENST00000409311.1_Intron	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	900	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TGTAAAGCATTCTCATAGCAA	0.378000													31	44					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65124824	65124824	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:65124824C>T	ENST00000358691.5	-	24	3496	c.3330G>A	c.(3328-3330)cgG>cgA	p.R1110R	HELZ_ENST00000580168.1_Silent_p.R1111R	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GTCTTAGAGCCCGGGGGATAA	0.428000													34	170					0	0	1	0	0
PPAN-P2RY11	0	broad.mit.edu	37	19	10221710	10221710	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10221710C>A	ENST00000428358.1	+	12	1463	c.1291C>A	c.(1291-1293)Ctt>Att	p.L431I	PPAN-P2RY11_ENST00000393796.4_Intron|PPAN_ENST00000393793.1_Missense_Mutation_p.L378I|PPAN_ENST00000556468.1_Intron|PPAN_ENST00000253107.7_Missense_Mutation_p.L431I	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		431					RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			CAGGGGTCGCCTTTGTGACCA	0.662000													7	26					8.12818e-05	8.34155e-05	1	1	0
ZNF536	9745	broad.mit.edu	37	19	30934839	30934839	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:30934839G>A	ENST00000355537.3	+	2	517	c.370G>A	c.(370-372)Gcc>Acc	p.A124T		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CGAGGACGACGCCCGCAAGAA	0.632000													11	20					0	0	1	0	0
RIMS1	0	broad.mit.edu	37	6	72967959	72967959	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:72967959C>T	ENST00000264839.7	+	17	2902	c.2902C>T	c.(2902-2904)Cgt>Tgt	p.R968C	RIMS1_ENST00000348717.5_Missense_Mutation_p.R967C|RIMS1_ENST00000491071.2_Missense_Mutation_p.R968C|RIMS1_ENST00000401910.3_Missense_Mutation_p.R441C|RIMS1_ENST00000521978.1_Missense_Mutation_p.R968C|RIMS1_ENST00000425662.2_Missense_Mutation_p.R361C|RIMS1_ENST00000520567.1_Missense_Mutation_p.R967C|RIMS1_ENST00000517827.1_Missense_Mutation_p.R427C|RIMS1_ENST00000522291.1_Missense_Mutation_p.R967C|RIMS1_ENST00000518273.1_Missense_Mutation_p.R968C|RIMS1_ENST00000538414.1_5'UTR|RIMS1_ENST00000523963.1_Missense_Mutation_p.R442C|RIMS1_ENST00000517960.1_Missense_Mutation_p.R967C			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	968					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GCCGCGTTCACGTTTACCAAA	0.433000													12	17					0	0	1	0	0
KAL1	3730	broad.mit.edu	37	X	8522091	8522091	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:8522091G>A	ENST00000262648.3	-	9	1405	c.1256C>T	c.(1255-1257)cCt>cTt	p.P419L		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	419					axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						TCTTTGAAAAGGGAGTTGTGT	0.413000													30	3					0	0	1	0	0
GRIP1	23426	broad.mit.edu	37	12	66849299	66849299	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:66849299T>C	ENST00000359742.4	-	11	1484	c.1244A>G	c.(1243-1245)tAc>tGc	p.Y415C	GRIP1_ENST00000398016.3_Missense_Mutation_p.Y363C|GRIP1_ENST00000286445.7_Missense_Mutation_p.Y415C			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	415					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		ACTCAGGCTGTATGCACTCAT	0.532000													22	34					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117853141	117853141	+	Missense_Mutation	SNP	C	C	T	rs141377575		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:117853141C>T	ENST00000350763.4	-	2	568	c.157G>A	c.(157-159)Gtt>Att	p.V53I	TNC_ENST00000345230.3_Missense_Mutation_p.V53I|TNC_ENST00000423613.2_Missense_Mutation_p.V53I|TNC_ENST00000535648.1_Missense_Mutation_p.V53I|TNC_ENST00000537320.1_Missense_Mutation_p.V53I|TNC_ENST00000346706.3_Missense_Mutation_p.V53I|TNC_ENST00000340094.3_Missense_Mutation_p.V53I|TNC_ENST00000542877.1_Missense_Mutation_p.V53I|TNC_ENST00000341037.4_Missense_Mutation_p.V53I	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	53					cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						ATGTTGTAAACGTGGTTAAAC	0.572000													32	48					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116599520	116599520	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:116599520C>T	ENST00000395715.3	-	5	2985	c.2408G>A	c.(2407-2409)cGc>cAc	p.R803H	TRPS1_ENST00000220888.5_Missense_Mutation_p.R790H|TRPS1_ENST00000519674.1_Missense_Mutation_p.R790H|TRPS1_ENST00000520276.1_Missense_Mutation_p.R794H|TRPS1_ENST00000519076.1_Missense_Mutation_p.R544H	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	790	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AGTCACATTGCGAAGGTCATC	0.567000									Langer-Giedion syndrome				30	159					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109794459	109794459	+	Silent	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109794459C>G	ENST00000271332.3	+	1	1819	c.1758C>G	c.(1756-1758)ggC>ggG	p.G586G		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	586	Cadherin 4.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GAGACCATGGCACTCCAGCAC	0.542000													12	20					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46656678	46656678	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:46656678C>T	ENST00000544460.1	+	1	1067	c.813C>T	c.(811-813)agC>agT	p.S271S	TDRD6_ENST00000316081.6_Silent_p.S271S	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	271					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AGCTCCGCAGCGTCTCGCAGG	0.627000													4	6					0	0	1	0	0
TBC1D25	4943	broad.mit.edu	37	X	48417680	48417680	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:48417680C>T	ENST00000376771.4	+	5	992	c.651C>T	c.(649-651)ccC>ccT	p.P217P	TBC1D25_ENST00000537536.1_5'UTR|TBC1D25_ENST00000481090.1_3'UTR|TBC1D25_ENST00000427713.1_3'UTR	NM_002536.2	NP_002527.1	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	217						intracellular	Rab GTPase activator activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						TCTCCCGACCCGAGGAGTTGC	0.587000													5	2					0	0	1	0	0
TACR1	6869	broad.mit.edu	37	2	75425955	75425955	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:75425955C>T	ENST00000305249.4	-	1	871	c.106G>A	c.(106-108)Gca>Aca	p.A36T	TACR1_ENST00000409848.3_Missense_Mutation_p.A36T	NM_001058.3	NP_001049.1	P25103	NK1R_HUMAN	tachykinin receptor 1	36					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(8)|ovary(1)|skin(1)	24					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	TAGGCAGCTGCCCAAAGGACA	0.527000													7	8					0	0	1	0	0
EOGT	285203	broad.mit.edu	37	3	69056865	69056865	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:69056865G>A	ENST00000540955.1	-	0	850				EOGT_ENST00000540764.1_Splice_Site_p.T39_splice|EOGT_ENST00000295571.5_Splice_Site_p.T140_splice|EOGT_ENST00000383701.3_Splice_Site_p.T140_splice					EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase																		AATACCCACCGTTTCCTTAGG	0.403000													43	76					0	0	1	0	0
SLC25A10	1468	broad.mit.edu	37	17	79682084	79682084	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79682084C>T	ENST00000331531.5	+	2	315	c.195C>T	c.(193-195)agC>agT	p.S65S	SLC25A10_ENST00000571730.1_Silent_p.S220S|SLC25A10_ENST00000350690.5_Silent_p.S65S|SLC25A10_ENST00000545862.1_Silent_p.S22S|SLC25A10_ENST00000541223.1_Silent_p.S220S	NM_001270888.1	NP_001257817.1	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	65					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	GCGGCCTGAGCGCCTCGCTGT	0.647000													3	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179452941	179452941	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179452941G>A	ENST00000589042.1	-	305	63417	c.63193C>T	c.(63193-63195)Cct>Tct	p.P21065S	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P12192S|TTN_ENST00000591111.1_Missense_Mutation_p.P19424S|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P12000S|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P18497S|TTN_ENST00000359218.5_Missense_Mutation_p.P12125S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19424	Fibronectin type-III 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGGACCAGGTGGCTCTGAA	0.373000													12	32					0	0	1	0	0
CYP2B7P1	0	broad.mit.edu	37	19	41450288	41450288	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41450288G>A	ENST00000599198.1	+	0	1071					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						GCCCTCCAGCGCTTGATGACC	0.498000													4	16					0	0	1	0	0
TUBD1	51174	broad.mit.edu	37	17	57952052	57952052	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:57952052T>C	ENST00000325752.3	-	6	1059	c.782A>G	c.(781-783)gAg>gGg	p.E261G	TUBD1_ENST00000340993.6_Intron|TUBD1_ENST00000394239.3_Missense_Mutation_p.E261G|TUBD1_ENST00000376094.4_Intron|TUBD1_ENST00000346141.6_Intron|TUBD1_ENST00000539018.1_Missense_Mutation_p.E45G|TUBD1_ENST00000592426.1_Missense_Mutation_p.E261G	NM_016261.3	NP_057345.2	Q9UJT1	TBD_HUMAN	tubulin, delta 1	261					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			AACTAAATGCTCCATTAAGTC	0.348000													41	68					0	0	1	0	0
FN3K	64122	broad.mit.edu	37	17	80696418	80696418	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80696418G>A	ENST00000300784.7	+	2	257	c.195G>A	c.(193-195)acG>acA	p.T65T		NM_022158.3	NP_071441.1	Q9H479	FN3K_HUMAN	fructosamine 3 kinase	65					fructoselysine metabolic process		fructosamine-3-kinase activity			central_nervous_system(1)|kidney(1)|lung(1)|urinary_tract(1)	4	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			TCAGGAGCACGGGCCTGGTGC	0.632000													20	28					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160851031	160851031	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160851031C>A	ENST00000326245.3	-	5	592	c.477G>T	c.(475-477)caG>caT	p.Q159H	ITLN1_ENST00000487531.1_5'UTR	NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	159	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TTCTCCAGTGCTGCATGGGGG	0.562000													13	58					4.93089e-13	5.3475e-13	1	1	0
ZNF410	57862	broad.mit.edu	37	14	74371737	74371737	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:74371737G>T	ENST00000555044.1	+	7	1058	c.864G>T	c.(862-864)aaG>aaT	p.K288N	ZNF410_ENST00000442160.3_Missense_Mutation_p.K305N|ZNF410_ENST00000412490.3_3'UTR|ZNF410_ENST00000324593.6_Missense_Mutation_p.K288N|ZNF410_ENST00000540593.1_Missense_Mutation_p.K215N|RP5-1021I20.5_ENST00000554009.1_RNA|ZNF410_ENST00000334521.4_Missense_Mutation_p.K235N	NM_001242928.1|NM_021188.2	NP_001229857.1|NP_067011.1	Q86VK4	ZN410_HUMAN	zinc finger protein 410	288					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(234;0.00369)		GCTGTGGTAAGCAGTTTACTA	0.527000													18	51					1.01871e-10	1.09092e-10	1	1	0
FLNB	2317	broad.mit.edu	37	3	58081884	58081884	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58081884A>G	ENST00000357272.4	+	6	1088	c.923A>G	c.(922-924)gAc>gGc	p.D308G	FLNB_ENST00000490882.1_Missense_Mutation_p.D308G|FLNB_ENST00000295956.4_Missense_Mutation_p.D308G|FLNB_ENST00000493452.1_Missense_Mutation_p.D139G|FLNB_ENST00000358537.3_Missense_Mutation_p.D308G|FLNB_ENST00000429972.2_Missense_Mutation_p.D308G|FLNB_ENST00000419752.2_Missense_Mutation_p.D139G|FLNB_ENST00000348383.5_Missense_Mutation_p.D308G			O75369	FLNB_HUMAN	filamin B, beta	308					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding	p.D308G(1)		NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GTGACCCCTGACAGTGACAAG	0.547000													14	13					0	0	1	0	0
ABCD1	215	broad.mit.edu	37	X	153001621	153001621	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153001621C>T	ENST00000218104.3	+	3	1536	c.1137C>T	c.(1135-1137)agC>agT	p.S379S	U52111.14_ENST00000434284.1_RNA	NM_000033.3	NP_000024.2	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member 1	379	ABC transmembrane type-1.				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(2)	18	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCTGGTGAGCGAGCGCACAG	0.632000													17	3					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29001909	29001909	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:29001909G>T	ENST00000282397.4	-	9	1507	c.1256C>A	c.(1255-1257)aCt>aAt	p.T419N	FLT1_ENST00000539099.1_Missense_Mutation_p.T419N|FLT1_ENST00000541932.1_Missense_Mutation_p.T419N	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	419	Ig-like C2-type 4.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TAGAGTGGCAGTGAGGTTTTT	0.368000													22	31					1.77063e-15	1.9385e-15	1	1	0
LRBA	987	broad.mit.edu	37	4	151826995	151826995	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:151826995C>T	ENST00000535741.1	-	13	2223	c.1750G>A	c.(1750-1752)Gcc>Acc	p.A584T	LRBA_ENST00000357115.3_Missense_Mutation_p.A584T|LRBA_ENST00000507224.1_Missense_Mutation_p.A584T|LRBA_ENST00000510413.1_Missense_Mutation_p.A584T			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	584						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					ATTACCTTGGCTGGGGTATGA	0.343000													4	47					0	0	1	0	0
C22orf31	25770	broad.mit.edu	37	22	29454920	29454920	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:29454920G>A	ENST00000216071.4	-	3	734	c.683C>T	c.(682-684)cCt>cTt	p.P228L		NM_015370.1	NP_056185.1	O95567	CV031_HUMAN	chromosome 22 open reading frame 31	228										cervix(1)|endometrium(1)|kidney(17)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	27						GGTCCCTGAAGGATTCCACAG	0.567000													22	43					0	0	1	0	0
CYLD	1540	broad.mit.edu	37	16	50830336	50830336	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:50830336A>G	ENST00000540145.1	+	19	3203	c.2788A>G	c.(2788-2790)Aga>Gga	p.R930G	CYLD_ENST00000569418.1_Missense_Mutation_p.R927G|RP11-327F22.4_ENST00000575917.1_RNA|CYLD_ENST00000568704.2_Missense_Mutation_p.R745G|CYLD_ENST00000427738.3_Missense_Mutation_p.R930G|RP11-327F22.4_ENST00000564510.1_RNA|CYLD_ENST00000398568.2_Missense_Mutation_p.R927G|CYLD_ENST00000311559.9_Missense_Mutation_p.R930G|CYLD_ENST00000564326.1_Missense_Mutation_p.R927G			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	930					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				GGACTCCAGGAGAATCCAAGG	0.468000			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				15	34					0	0	1	0	0
ATP6V0A1	535	broad.mit.edu	37	17	40652751	40652751	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40652751A>G	ENST00000343619.4	+	16	1829	c.1706A>G	c.(1705-1707)tAc>tGc	p.Y569C	ATP6V0A1_ENST00000544137.1_Missense_Mutation_p.Y215C|ATP6V0A1_ENST00000546249.1_Missense_Mutation_p.Y569C|ATP6V0A1_ENST00000393829.2_Missense_Mutation_p.Y569C|ATP6V0A1_ENST00000537728.1_Missense_Mutation_p.Y526C|ATP6V0A1_ENST00000264649.6_Missense_Mutation_p.Y576C|ATP6V0A1_ENST00000585525.1_Missense_Mutation_p.Y526C	NM_001130021.1	NP_001123493.1	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	569					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		CTGAATATCTACTTTGGATTT	0.383000													37	49					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113748834	113748834	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113748834G>A	ENST00000397030.1	+	27	3096	c.3059G>A	c.(3058-3060)aGc>aAc	p.S1020N	MCF2L_ENST00000442652.2_Missense_Mutation_p.S1017N|MCF2L_ENST00000421756.1_Missense_Mutation_p.S991N|MCF2L_ENST00000375608.3_Missense_Mutation_p.S1017N|MCF2L_ENST00000535094.2_Missense_Mutation_p.S987N|MCF2L_ENST00000434480.2_Missense_Mutation_p.S993N|MCF2L_ENST00000375604.2_Missense_Mutation_p.S1044N|MCF2L_ENST00000375601.3_Missense_Mutation_p.S991N|MCF2L_ENST00000423482.2_Missense_Mutation_p.S985N			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	1017					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TTAGGTTGGAGCAAAACGTCC	0.617000													8	10					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112357079	112357079	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:112357079G>A	ENST00000206423.3	-	2	2627	c.1674C>T	c.(1672-1674)aaC>aaT	p.N558N	CCDC80_ENST00000439685.2_Silent_p.N558N	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	558	Lys-rich.									breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						acttgtctgcgttctcattct	0.373000													9	10					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57741447	57741447	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57741447C>T	ENST00000360716.3	+	8	1155	c.934C>T	c.(934-936)Cgc>Tgc	p.R312C	CCDC135_ENST00000336825.8_Missense_Mutation_p.R247C|CCDC135_ENST00000394337.4_Missense_Mutation_p.R312C			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	312						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						ATCGGGGAAGCGCGAGGTGCC	0.587000													9	14					0	0	1	0	0
SLC15A4	121260	broad.mit.edu	37	12	129293375	129293375	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:129293375C>T	ENST00000266771.5	-	5	1255	c.1216G>A	c.(1216-1218)Gcc>Acc	p.A406T	SLC15A4_ENST00000544112.1_Missense_Mutation_p.A69T	NM_145648.3	NP_663623.1	Q8N697	S15A4_HUMAN	solute carrier family 15 (oligopeptide transporter), member 4	406					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|skin(1)	22	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		ATGCCCACGGCGATCCTCTTC	0.552000													16	23					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23476327	23476327	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:23476327C>T	ENST00000216036.4	-	4	503	c.307G>A	c.(307-309)Gcc>Acc	p.A103T		NM_014433.2	NP_055248.1	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region gene 1	103							binding			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	18	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		TCTAGAAAGGCGTATCTAGGG	0.557000													7	12					0	0	1	0	0
GRM8	0	broad.mit.edu	37	7	126882824	126882824	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:126882824G>A	ENST00000339582.2	-	2	1243	c.435C>T	c.(433-435)gaC>gaT	p.D145D	GRM8_ENST00000358373.3_Silent_p.D145D|GRM8_ENST00000444921.2_Silent_p.D145D|GRM8_ENST00000405249.1_Silent_p.D145D			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	145					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CAGAAATCTTGTCGGGCTTGG	0.443000										HNSCC(24;0.065)			27	39					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17544427	17544427	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:17544427C>T	ENST00000005226.7	-	12	922	c.923G>A	c.(922-924)cGg>cAg	p.R308Q	USH1C_ENST00000527020.1_Missense_Mutation_p.R289Q|USH1C_ENST00000527720.1_Missense_Mutation_p.R277Q|USH1C_ENST00000318024.4_Missense_Mutation_p.R308Q	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	308					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding	p.R308Q(1)		central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						CTCACGCTGCCGCGCCTCTGC	0.657000													5	8					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108382110	108382110	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:108382110G>T	ENST00000265843.4	-	6	4234	c.4124C>A	c.(4123-4125)cCt>cAt	p.P1375H	EXPH5_ENST00000525344.1_Missense_Mutation_p.P1368H|EXPH5_ENST00000428840.1_Missense_Mutation_p.P1299H|EXPH5_ENST00000443411.1_Missense_Mutation_p.P1187H	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1375					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		ATCACCTAGAGGTGTTTTAGC	0.378000													23	34					1.28384e-07	1.34682e-07	1	1	0
TRAPPC12	51112	broad.mit.edu	37	2	3447573	3447573	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:3447573C>T	ENST00000324266.5	+	6	1636	c.1441C>T	c.(1441-1443)Cgc>Tgc	p.R481C	TRAPPC12_ENST00000469147.1_3'UTR|TRAPPC12_ENST00000382110.2_Missense_Mutation_p.R481C	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	481							binding										CTTCTCGATGCGCATCTTGCA	0.547000													4	14					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80046084	80046084	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80046084G>A	ENST00000306749.2	-	17	2911	c.2693C>T	c.(2692-2694)aCg>aTg	p.T898M		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	898					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GCGGGCCAGCGTCTTCCACAC	0.657000													17	19					0	0	1	0	0
TASP1	55617	broad.mit.edu	37	20	13604122	13604122	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:13604122C>T	ENST00000337743.4	-	4	373	c.253G>A	c.(253-255)Gca>Aca	p.A85T	TASP1_ENST00000544472.1_Missense_Mutation_p.A85T|TASP1_ENST00000539805.1_Missense_Mutation_p.A85T|TASP1_ENST00000480436.1_5'UTR	NM_017714.2	NP_060184.2	Q9H6P5	TASP1_HUMAN	taspase, threonine aspartase, 1	85					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(11)|liver(1)|lung(11)|stomach(2)|urinary_tract(2)	31						GCAGTGACTGCGTCAGTTGCA	0.363000													14	17					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7606907	7606907	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7606907G>A	ENST00000221249.6	+	13	1520	c.1089G>A	c.(1087-1089)tcG>tcA	p.S363S	PNPLA6_ENST00000414982.3_Silent_p.S411S|PNPLA6_ENST00000600737.1_Silent_p.S402S|PNPLA6_ENST00000545201.2_Silent_p.S363S|PNPLA6_ENST00000450331.3_Silent_p.S363S	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	402					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						AAACCCCCTCGGCCCCTCTGC	0.627000													16	24					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102494416	102494416	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:102494416C>T	ENST00000360184.4	+	48	9570	c.9406C>T	c.(9406-9408)Cca>Tca	p.P3136S		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3136	AAA 4 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GCTGCCGCAGCCACCATCCCA	0.448000													35	41					0	0	1	0	0
SERPINC1	462	broad.mit.edu	37	1	173876636	173876636	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:173876636G>A	ENST00000367698.3	-	6	1288	c.1170C>T	c.(1168-1170)ggC>ggT	p.G390G		NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	390					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	GGTCATCTCGGCCTTCTGCAA	0.463000													12	137					0	0	1	0	0
SERPINF1	5176	broad.mit.edu	37	17	1680697	1680697	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1680697C>T	ENST00000254722.4	+	8	1377	c.1214C>T	c.(1213-1215)gCc>gTc	p.A405V		NM_002615.5	NP_002606.3	P36955	PEDF_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	405					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	16						GACACAGGGGCCCTTCTCTTC	0.547000													41	76					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19329842	19329842	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19329842G>A	ENST00000252575.5	+	3	235	c.192G>A	c.(190-192)caG>caA	p.Q64Q		NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	64	Ig-like V-type.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			TTACCCTGCAGCCACGGCCAA	0.662000													11	12					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11052975	11052975	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:11052975C>T	ENST00000295082.1	+	1	913	c.423C>T	c.(421-423)atC>atT	p.I141I		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	141						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		TGGAGGAGATCGCGCGCCGCG	0.637000													14	15					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14286996	14286996	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:14286996C>T	ENST00000344204.4	+	4	388	c.364C>T	c.(364-366)Cgt>Tgt	p.R122C	TRIO_ENST00000537187.1_Missense_Mutation_p.R122C|TRIO_ENST00000509967.2_Missense_Mutation_p.R73C	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	122	CRAL-TRIO.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GGTCTGCAAGCGTGGCTTCAC	0.572000													16	35					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23853760	23853760	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23853760G>A	ENST00000405093.3	-	36	5526	c.5456C>T	c.(5455-5457)gCg>gTg	p.A1819V	MYH6_ENST00000356287.3_Missense_Mutation_p.A1819V	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1819					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCGCACCCGCGCTTCCAGCTT	0.632000													19	71					0	0	1	0	0
MRGPRE	116534	broad.mit.edu	37	11	3249775	3249775	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3249775C>T	ENST00000389832.5	-	2	561	c.255G>A	c.(253-255)ctG>ctA	p.L85L	AC109309.4_ENST00000418995.2_RNA|MRGPRE_ENST00000436689.2_Silent_p.L84L			Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	84						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCGGCCTTGCAGCAAGTCGG	0.632000													20	24					0	0	1	0	0
FHOD3	80206	broad.mit.edu	37	18	34320769	34320769	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:34320769G>A	ENST00000257209.4	+	18	3324	c.3202G>A	c.(3202-3204)Gca>Aca	p.A1068T	FHOD3_ENST00000591635.1_Missense_Mutation_p.A264T|FHOD3_ENST00000592128.1_Missense_Mutation_p.A47T|FHOD3_ENST00000590592.1_Missense_Mutation_p.A1243T|FHOD3_ENST00000359247.4_Missense_Mutation_p.A1051T|FHOD3_ENST00000445677.1_Missense_Mutation_p.A1030T	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	1051	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				TCACCTCTGGGCATTCAAAAT	0.512000													4	45					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214826195	214826195	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:214826195C>T	ENST00000366955.3	+	16	8353	c.8185C>T	c.(8185-8187)Cga>Tga	p.R2729*	CENPF_ENST00000467765.1_3'UTR	NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2825	Sufficient for centromere localization.|Sufficient for self-association.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CCAGACATACCGAGAGAAATT	0.338000													10	64					0	0	1	0	0
ZC3H18	124245	broad.mit.edu	37	16	88666280	88666280	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:88666280G>A	ENST00000301011.5	+	6	1212	c.1012G>A	c.(1012-1014)Gaa>Aaa	p.E338K	ZC3H18_ENST00000452588.2_Missense_Mutation_p.E362K	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	338						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		TGGCGAAGACGAACGGGAATT	0.423000													38	77					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897510	175897510	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:175897510G>A	ENST00000359240.3	+	5	1504	c.834G>A	c.(832-834)acG>acA	p.T278T	ADAM29_ENST00000404450.4_Silent_p.T278T|ADAM29_ENST00000514159.1_Silent_p.T278T|ADAM29_ENST00000445694.1_Silent_p.T278T	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	278	Peptidase M12B.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AGAACATTACGCCCCGGATGC	0.428000													16	94					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82880022	82880022	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:82880022G>A	ENST00000298281.4	+	8	3097	c.2645G>A	c.(2644-2646)cGt>cAt	p.R882H		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	882	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						GAGGGACATCGTGGTCAACCT	0.552000													24	30					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26291196	26291196	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:26291196C>T	ENST00000335473.7	+	28	4867	c.4617C>T	c.(4615-4617)tgC>tgT	p.C1539C	MYO18B_ENST00000407587.2_Silent_p.C1540C|CTA-125H2.2_ENST00000600211.1_RNA|CTA-125H2.2_ENST00000599792.1_RNA|CTA-125H2.2_ENST00000597548.1_RNA|CTA-125H2.2_ENST00000596813.1_RNA|CTA-125H2.2_ENST00000600269.1_RNA|CTA-125H2.2_ENST00000595102.1_RNA|CTA-125H2.2_ENST00000597284.1_RNA|CTA-125H2.2_ENST00000594585.1_RNA|CTA-125H2.2_ENST00000594542.1_RNA|CTA-125H2.2_ENST00000593715.1_RNA|CTA-125H2.2_ENST00000453457.2_RNA|CTA-125H2.2_ENST00000599080.1_RNA|CTA-125H2.2_ENST00000594856.1_RNA|MYO18B_ENST00000536101.1_Silent_p.C1539C|CTA-125H2.2_ENST00000597614.1_RNA	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1539	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TGCAGCAATGCGAGGAGAGGC	0.557000													6	5					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152733421	152733421	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:152733421G>T	ENST00000368773.1	+	2	1415	c.1357G>T	c.(1357-1359)Ggg>Tgg	p.G453W	KPRP_ENST00000606109.1_Missense_Mutation_p.G453W	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	453	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTCGCCCAGGGCAGTGTGA	0.617000													23	34					1.10923e-09	1.18008e-09	1	1	0
C3orf17	25871	broad.mit.edu	37	3	112724716	112724716	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:112724716T>C	ENST00000314400.5	-	9	1562	c.1371A>G	c.(1369-1371)ccA>ccG	p.P457P	C3orf17_ENST00000393857.2_Silent_p.P321P|C3orf17_ENST00000383675.2_Silent_p.P387P	NM_015412.3	NP_056227.2	Q6NW34	CC017_HUMAN	chromosome 3 open reading frame 17	457						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(2)|lung(6)|prostate(2)|skin(1)	13						ACTTTCTCTGTGGTTTCCTTT	0.433000													16	33					0	0	1	0	0
PECR	55825	broad.mit.edu	37	2	216923661	216923661	+	Missense_Mutation	SNP	C	C	T	rs138408075		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:216923661C>T	ENST00000265322.7	-	4	537	c.463G>A	c.(463-465)Gtc>Atc	p.V155I	PECR_ENST00000497889.1_5'UTR	NM_018441.5	NP_060911.2	Q9BY49	PECR_HUMAN	peroxisomal trans-2-enoyl-CoA reductase	155					fatty acid biosynthetic process|regulation of apoptosis	peroxisome	binding|trans-2-enoyl-CoA reductase (NADPH) activity			endometrium(2)|kidney(1)|liver(1)|lung(9)|stomach(1)	14		Renal(323;0.0327)		Epithelial(149;3.8e-06)|all cancers(144;0.000272)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Adenine(DB00173)	ATGATATTGACGATAGATCCT	0.383000													12	32					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1730475	1730475	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1730475C>T	ENST00000313288.4	+	4	1452	c.1346C>T	c.(1345-1347)gCt>gTt	p.A449V		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	449						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CAGTTGCATGCTGGGCCTGCC	0.642000													11	13					0	0	1	0	0
DNA2	1763	broad.mit.edu	37	10	70182590	70182590	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:70182590A>G	ENST00000399180.2	-	15	2523	c.2524T>C	c.(2524-2526)Ttt>Ctt	p.F842L	DNA2_ENST00000399179.2_Intron|DNA2_ENST00000358410.3_Missense_Mutation_p.F756L			P51530	DNA2L_HUMAN	DNA replication helicase/nuclease 2	756					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)	20						CAAAAATCAAAAATTTTACGG	0.353000													8	36					0	0	1	0	0
NADSYN1	55191	broad.mit.edu	37	11	71169582	71169582	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:71169582C>T	ENST00000319023.2	+	3	443	c.255C>T	c.(253-255)gaC>gaT	p.D85D		NM_018161.4	NP_060631.2	Q6IA69	NADE_HUMAN	NAD synthetase 1	85	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	25					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TCATCTGCGACGTGGGGATGT	0.567000													22	32					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7330138	7330138	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7330138G>T	ENST00000333870.3	+	3	902	c.828G>T	c.(826-828)tgG>tgT	p.W276C	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_3'UTR	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	276						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				CTGAGCAGTGGGCCTCGTCTC	0.652000													8	18					3.09899e-07	3.24337e-07	1	1	0
EXOC6B	23233	broad.mit.edu	37	2	72562096	72562096	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:72562096C>T	ENST00000272427.6	-	20	2306	c.2176G>A	c.(2176-2178)Gcc>Acc	p.A726T	EXOC6B_ENST00000490919.1_5'UTR	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	726					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						TCGATGAAGGCCAACTGCAGC	0.448000													5	41					0	0	1	0	0
TTC25	83538	broad.mit.edu	37	17	40095414	40095414	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40095414C>T	ENST00000591658.1	+	0	1115							Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25							cytoplasm	protein binding			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				ACCTGGAGATCGCCAAGGAAT	0.587000													8	4					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2397994	2397994	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:2397994G>T	ENST00000202625.2	+	10	1514	c.1453G>T	c.(1453-1455)Gac>Tac	p.D485Y	TGM6_ENST00000381423.1_Missense_Mutation_p.D485Y	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	485					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	CTGGCGTGACGACCTCCTGGA	0.637000													6	15					0.0293803	0.0295506	1	1	0
IP6K3	117283	broad.mit.edu	37	6	33694579	33694579	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33694579G>A	ENST00000451316.1	-	5	1053	c.518C>T	c.(517-519)cCg>cTg	p.P173L	IP6K3_ENST00000293756.4_Missense_Mutation_p.P173L	NM_001142883.1	NP_001136355.1	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	173					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity			skin(1)	1						CAGGCCCCACGGGTTGAAGCT	0.607000													26	45					0	0	1	0	0
PCNA	5111	broad.mit.edu	37	20	5098243	5098243	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:5098243C>T	ENST00000379160.3	-	5	697	c.455G>A	c.(454-456)aGc>aAc	p.S152N	PCNA_ENST00000379143.5_Missense_Mutation_p.S152N	NM_002592.2	NP_002583.1	P12004	PCNA_HUMAN	proliferating cell nuclear antigen	152					cell proliferation|DNA strand elongation involved in DNA replication|mismatch repair|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|positive regulation of deoxyribonuclease activity|regulation of DNA replication|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair|translesion synthesis	cytoplasm|DNA replication factor C complex|microtubule cytoskeleton|nuclear replication fork|nucleoplasm|PCNA complex|PCNA-p21 complex	dinucleotide insertion or deletion binding|DNA polymerase processivity factor activity|MutLalpha complex binding|purine-specific mismatch base pair DNA N-glycosylase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)	9						TCCAATATGGCTGAGATCTCG	0.373000								DNA polymerases (catalytic subunits)					5	114					0	0	1	0	0
ESRRA	2101	broad.mit.edu	37	11	64074903	64074903	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64074903C>T	ENST00000405666.1	+	2	486	c.252C>T	c.(250-252)gaC>gaT	p.D84D	ESRRA_ENST00000406310.1_Silent_p.D84D|ESRRA_ENST00000000442.6_Silent_p.D84D			P11474	ERR1_HUMAN	estrogen-related receptor alpha	84					positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14						TCTGTGGGGACGTGGCCTCCG	0.667000													7	13					0	0	1	0	0
C16orf11	146325	broad.mit.edu	37	16	613342	613342	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:613342G>A	ENST00000409413.3	+	2	327	c.48G>A	c.(46-48)gcG>gcA	p.A16A		NM_145270.2	NP_660313.1	P0CG20	CP011_HUMAN	chromosome 16 open reading frame 11	16										central_nervous_system(1)|endometrium(1)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10						GGGCGAGGGCGCGGTCTCGGA	0.662000													9	15					0	0	1	0	0
LIMS2	55679	broad.mit.edu	37	2	128412098	128412098	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128412098C>T	ENST00000409455.1	-	4	879	c.244G>A	c.(244-246)Gtc>Atc	p.V82I	LIMS2_ENST00000324938.5_Missense_Mutation_p.V111I|LIMS2_ENST00000355119.4_Missense_Mutation_p.V87I|LIMS2_ENST00000409808.2_Missense_Mutation_p.V82I|LIMS2_ENST00000410011.1_Missense_Mutation_p.V82I|LIMS2_ENST00000545738.2_Missense_Mutation_p.V109I			Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	87	LIM zinc-binding 2.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		GCCTTGATGACGCGGCCAATG	0.612000													33	33					0	0	1	0	0
SPATA5L1	79029	broad.mit.edu	37	15	45706807	45706807	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:45706807T>C	ENST00000305560.6	+	4	1572	c.1473T>C	c.(1471-1473)gtT>gtC	p.V491V	SPATA5L1_ENST00000559860.1_Silent_p.V491V	NM_024063.2	NP_076968.2	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	491						cytoplasm	ATP binding|nucleoside-triphosphatase activity			kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		GGGAATTTGTTAGAATGGGCC	0.453000													17	20					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136624249	136624249	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:136624249C>T	ENST00000264156.2	-	5	725	c.665G>A	c.(664-666)cGc>cAc	p.R222H		NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	222					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TTCTAAACTGCGGGGGATACT	0.463000													4	124					0	0	1	0	0
AMPD2	271	broad.mit.edu	37	1	110169887	110169887	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110169887G>A	ENST00000256578.3	+	7	1331	c.971G>A	c.(970-972)cGc>cAc	p.R324H	AMPD2_ENST00000358729.4_Missense_Mutation_p.R249H|AMPD2_ENST00000393688.3_Missense_Mutation_p.R205H|AMPD2_ENST00000342115.4_Missense_Mutation_p.R243H|AMPD2_ENST00000528667.1_Missense_Mutation_p.R324H|AMPD2_ENST00000528454.1_Missense_Mutation_p.R206H|AMPD2_ENST00000526301.1_3'UTR	NM_004037.7	NP_004028.3	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2	324					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding	p.R324H(1)		breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		TTGGGTCTGCGCATGGTGCGG	0.667000													20	46					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027835	37027835	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:37027835G>A	ENST00000358047.3	+	1	1404	c.1352G>A	c.(1351-1353)cGc>cAc	p.R451H		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	451								p.R451P(2)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCCCATCTCCGCCCAGAGCCT	0.617000													58	9					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71047617	71047617	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:71047617C>T	ENST00000272367.2	-	1	115	c.39G>A	c.(37-39)caG>caA	p.Q13Q	CLEC4F_ENST00000426626.1_Silent_p.Q13Q	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	13					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						GGGAGACACACTGGTTATCTG	0.617000													6	7					0	0	1	0	0
RAI14	26064	broad.mit.edu	37	5	34811225	34811225	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:34811225T>C	ENST00000265109.3	+	8	844		c.e8+2		RAI14_ENST00000397449.1_Splice_Site|RAI14_ENST00000428746.2_Splice_Site|RAI14_ENST00000515799.1_Splice_Site|RAI14_ENST00000503673.1_Splice_Site|RAI14_ENST00000512629.1_Splice_Site|RAI14_ENST00000506376.1_Splice_Site	NM_001145522.1|NM_015577.2	NP_001138994.1|NP_056392.2	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14							cell cortex|cytoskeleton	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(19)|lung(22)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(31;0.000191)					AAGTGGAAGGTACTCCAGAAT	0.398000													11	95					0	0	1	0	0
PTPN4	5775	broad.mit.edu	37	2	120714453	120714453	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:120714453T>G	ENST00000263708.2	+	21	2785	c.2014T>G	c.(2014-2016)Tcc>Gcc	p.S672A	PTPN4_ENST00000544261.1_Missense_Mutation_p.S305A	NM_002830.3	NP_002821.1	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	672	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|urinary_tract(1)	30					Alendronate(DB00630)	AATGACAATGTCCTGTGCCAA	0.294000													23	65					0	0	1	0	0
SGTA	6449	broad.mit.edu	37	19	2762503	2762503	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2762503C>T	ENST00000221566.2	-	7	798		c.e7+1			NM_003021.3	NP_003012.1	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha						interspecies interaction between organisms	cytoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGCACTCACGGGGCTGGGG	0.637000													26	40					0	0	1	0	0
PVRL2	5819	broad.mit.edu	37	19	45368708	45368708	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45368708G>A	ENST00000252483.5	+	2	269	c.269G>A	c.(268-270)gGt>gAt	p.G90D	PVRL2_ENST00000252485.4_Missense_Mutation_p.G90D	NM_001042724.1	NP_001036189.1	Q92692	PVRL2_HUMAN	poliovirus receptor-related 2 (herpesvirus entry mediator B)	90	Ig-like V-type.				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(6)|lung(5)	13	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		CCTAAGATGGGTCCCAGCTTC	0.637000													4	10					0	0	1	0	0
NODAL	4838	broad.mit.edu	37	10	72192802	72192802	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:72192802A>G	ENST00000287139.3	-	3	933	c.934T>C	c.(934-936)Tgt>Cgt	p.C312R		NM_018055.4	NP_060525.3	Q96S42	NODAL_HUMAN	nodal growth differentiation factor	312					growth	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	15						GGGGCACAACAAGTGGAAGGG	0.498000													37	46					0	0	1	0	0
EPHX1	2052	broad.mit.edu	37	1	226026519	226026519	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:226026519G>A	ENST00000366837.4	+	4	725	c.529G>A	c.(529-531)Gtt>Att	p.V177I	EPHX1_ENST00000272167.5_Missense_Mutation_p.V177I	NM_000120.3	NP_000111.1	P07099	HYEP_HUMAN	epoxide hydrolase 1, microsomal (xenobiotic)	177					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.197)					CGATGAGCACGTTTTTGAAGT	0.552000													4	87					0	0	1	0	0
NDOR1	27158	broad.mit.edu	37	9	140109367	140109367	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140109367C>T	ENST00000371521.4	+	8	1045	c.962C>T	c.(961-963)tCc>tTc	p.S321F	NDOR1_ENST00000427047.2_Missense_Mutation_p.S287F|NDOR1_ENST00000344894.5_Missense_Mutation_p.S321F|NDOR1_ENST00000458322.2_Missense_Mutation_p.S321F	NM_001144026.1	NP_001137498.1	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	321	FAD-binding FR-type.				cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding			breast(1)|endometrium(5)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GCCTGTCTATCCCTCCATGAG	0.632000													23	35					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2026842	2026842	+	Silent	SNP	G	G	A	rs141170833		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:2026842G>A	ENST00000262113.4	+	12	1431	c.1290G>A	c.(1288-1290)gtG>gtA	p.V430V	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	430	Fibronectin type-III 1.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		ATAATTGGGTGCAGTGCAATG	0.413000													39	76					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132474615	132474615	+	Missense_Mutation	SNP	G	G	A	rs77464971		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:132474615G>A	ENST00000333577.4	+	9	2733	c.2624G>A	c.(2623-2625)cGg>cAg	p.R875Q	EP400_ENST00000332482.4_Missense_Mutation_p.R802Q|EP400_ENST00000389561.2_Missense_Mutation_p.R839Q|EP400_ENST00000389562.2_Missense_Mutation_p.R838Q|EP400_ENST00000330386.6_Missense_Mutation_p.R839Q			Q96L91	EP400_HUMAN	E1A binding protein p400	875					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.R838Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TCCACGGCCCGGGAGATAGAG	0.577000													8	65					0	0	1	0	0
PMF1	11243	broad.mit.edu	37	1	156206122	156206122	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156206122G>T	ENST00000368277.3	+	4	421	c.412G>T	c.(412-414)Gca>Tca	p.A138S	PMF1_ENST00000368273.4_Missense_Mutation_p.A140S|PMF1-BGLAP_ENST00000320139.5_Intron|PMF1_ENST00000368279.3_Intron|PMF1-BGLAP_ENST00000490491.1_Missense_Mutation_p.A138S|PMF1-BGLAP_ENST00000368276.4_Intron|PMF1_ENST00000567140.1_Intron|PMF1_ENST00000565805.1_Intron	NM_007221.3	NP_009152.2			polyamine-modulated factor 1									p.A138S(1)		kidney(1)|large_intestine(2)|lung(3)	6	Hepatocellular(266;0.158)					CAGTGTTATGGCACCCTACTT	0.637000													7	73					2.0095e-06	2.09073e-06	1	1	0
CTNNAL1	8727	broad.mit.edu	37	9	111761528	111761528	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:111761528C>T	ENST00000374595.4	-	2	229	c.150G>A	c.(148-150)acG>acA	p.T50T	CTNNAL1_ENST00000325580.6_Silent_p.T50T|CTNNAL1_ENST00000374593.4_Silent_p.T50T|CTNNAL1_ENST00000325551.4_Silent_p.T50T			Q9UBT7	CTNL1_HUMAN	catenin (cadherin-associated protein), alpha-like 1	50					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity	p.T50T(1)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(4)|urinary_tract(2)	25				STAD - Stomach adenocarcinoma(157;0.0768)		GATTAATAAGCGTGGTGATCT	0.328000													20	102					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886567	3886567	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:3886567G>A	ENST00000319331.3	+	2	1003	c.242G>A	c.(241-243)aGc>aAc	p.S81N	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	81						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CTCTTACAGAGCAATAACATC	0.438000													17	43					0	0	1	0	0
EGR1	1958	broad.mit.edu	37	5	137803314	137803314	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137803314C>T	ENST00000239938.4	+	2	1448	c.1176C>T	c.(1174-1176)ggC>ggT	p.G392G		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	392					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCCACACAGGCGAAAAGCCCT	0.582000													25	42					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123010043	123010043	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:123010043C>T	ENST00000462833.1	-	18	4456	c.3244G>A	c.(3244-3246)Gag>Aag	p.E1082K	ADCY5_ENST00000309879.5_Missense_Mutation_p.E732K|ADCY5_ENST00000491190.1_Missense_Mutation_p.E740K	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	1082	Guanylate cyclase 2.				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		ACGTAGAACTCGGAGAAGTTG	0.592000													4	18					0	0	1	0	0
SLC7A7	9056	broad.mit.edu	37	14	23282294	23282294	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23282294G>A	ENST00000397532.3	-	2	839	c.314C>T	c.(313-315)gCc>gTc	p.A105V	SLC7A7_ENST00000397528.4_Missense_Mutation_p.A105V|SLC7A7_ENST00000554517.1_Intron|SLC7A7_ENST00000555702.1_Missense_Mutation_p.A105V|SLC7A7_ENST00000285850.7_Missense_Mutation_p.A105V|SLC7A7_ENST00000397529.2_Missense_Mutation_p.A105V			Q9UM01	YLAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	105					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		CAGGATATAGGCATAGCTGGC	0.557000													24	43					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4882006	4882006	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4882006G>A	ENST00000321919.9	-	5	587	c.511C>T	c.(511-513)Cgg>Tgg	p.R171W	GLYR1_ENST00000436648.5_Intron|GLYR1_ENST00000381983.3_Missense_Mutation_p.R171W|GLYR1_ENST00000586901.1_5'UTR|GLYR1_ENST00000591451.1_Missense_Mutation_p.R171W	NM_032569.3	NP_115958.2	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	171					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity	p.R171G(1)		endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						GGCCGACCCCGCTTCCGGGGA	0.498000													25	43					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151917819	151917819	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:151917819G>A	ENST00000355193.2	-	23	3719	c.3499_splice	c.e23-1	p.D1167_splice	KMT2C_ENST00000262189.6_Splice_Site_p.D1167_splice					lysine (K)-specific methyltransferase 2C																		TCTTGGGTGGGTCTAAAATTA	0.388000													19	21					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190428718	190428718	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190428718C>T	ENST00000261024.2	-	7	1420	c.994G>A	c.(994-996)Gcc>Acc	p.A332T		NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	332					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			TGAGTGTAGGCGTACCCTGTG	0.488000													5	9					0	0	1	0	0
CD47	961	broad.mit.edu	37	3	107778299	107778299	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:107778299C>A	ENST00000355354.7	-	5	807	c.691_splice	c.e5+1	p.A231_splice	CD47_ENST00000361309.5_Splice_Site_p.A231_splice	NM_198793.2	NP_942088.1	Q08722	CD47_HUMAN	CD47 molecule	231					blood coagulation|cell adhesion|cell junction assembly|integrin-mediated signaling pathway|leukocyte migration|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to plasma membrane	protein binding|thrombospondin receptor activity			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(3;0.0191)|Epithelial(53;0.118)			GAAAACTCACCTGTACTAAAC	0.299000													23	35					2.21704e-12	2.3975e-12	1	1	0
NCAPD2	9918	broad.mit.edu	37	12	6626006	6626006	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6626006C>T	ENST00000315579.5	+	10	1799	c.1000C>T	c.(1000-1002)Cgt>Tgt	p.R334C	NCAPD2_ENST00000545962.1_Missense_Mutation_p.R289C	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	334	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						TTACATGATGCGTAATGCTGT	0.502000													16	28					0	0	1	0	0
MVB12A	93343	broad.mit.edu	37	19	17533145	17533145	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17533145C>A	ENST00000317040.7	+	4	1346	c.291C>A	c.(289-291)gcC>gcA	p.A97A	MVB12A_ENST00000392702.2_Silent_p.A97A|MVB12A_ENST00000528515.1_Intron|MVB12A_ENST00000529939.1_Silent_p.A97A|MVB12A_ENST00000543795.1_Silent_p.A97A					multivesicular body subunit 12A																		TCCCAGAGGCCTCTGTGTCCA	0.597000													18	21					2.4624e-09	2.6129e-09	1	1	0
CR2	1380	broad.mit.edu	37	1	207640140	207640140	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:207640140C>T	ENST00000367057.3	+	2	517	c.328C>T	c.(328-330)Cat>Tat	p.H110Y	CR2_ENST00000367059.3_Missense_Mutation_p.H110Y|CR2_ENST00000367058.3_Missense_Mutation_p.H110Y|CR2_ENST00000458541.2_Missense_Mutation_p.H110Y	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	110	Sushi 2.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						ACCCTACAGACATGGTGATTC	0.418000													11	40					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730821	57730821	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:57730821G>A	ENST00000281282.5	+	2	702	c.624G>A	c.(622-624)ccG>ccA	p.P208P		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	208	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TGGAAGACCCGGCCAAATCTG	0.488000													52	107					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43122251	43122251	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43122251C>T	ENST00000267890.6	-	5	425	c.317G>A	c.(316-318)cGt>cAt	p.R106H	TTBK2_ENST00000567274.1_Missense_Mutation_p.R106H|TTBK2_ENST00000567840.1_Missense_Mutation_p.R106H	NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	106	Protein kinase.				cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		GGACTGGCTACGGCGAAGATC	0.428000													18	31					0	0	1	0	0
ENOSF1	55556	broad.mit.edu	37	18	683281	683281	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:683281G>A	ENST00000319815.6	-	3	1415	c.151C>T	c.(151-153)Cct>Tct	p.P51S	ENOSF1_ENST00000583973.1_5'UTR|ENOSF1_ENST00000383578.3_Missense_Mutation_p.P199S|ENOSF1_ENST00000340116.7_Missense_Mutation_p.P302S|ENOSF1_ENST00000580982.1_Missense_Mutation_p.P205S|ENOSF1_ENST00000251101.7_Missense_Mutation_p.P281S			Q7L5Y1	ENOF1_HUMAN	enolase superfamily member 1	281					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	10						ATGTCATCAGGGGAGGTTGGC	0.547000													33	49					0	0	1	0	0
KIAA1644	85352	broad.mit.edu	37	22	44692748	44692748	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:44692748G>A	ENST00000381176.4	-	3	217	c.85C>T	c.(85-87)Cgg>Tgg	p.R29W		NM_001099294.1	NP_001092764.1	Q3SXP7	K1644_HUMAN	KIAA1644	29						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				TCACAGACCCGGAAATGTGCA	0.592000													31	49					0	0	1	0	0
SEC14L1	6397	broad.mit.edu	37	17	75208225	75208225	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:75208225G>C	ENST00000413679.2	+	15	2108	c.1805G>C	c.(1804-1806)gGc>gCc	p.G602A	SEC14L1_ENST00000443798.4_Missense_Mutation_p.G602A|SEC14L1_ENST00000591437.1_Missense_Mutation_p.G568A|SEC14L1_ENST00000585618.1_Missense_Mutation_p.G602A|SEC14L1_ENST00000392476.2_Missense_Mutation_p.G602A|SEC14L1_ENST00000430767.4_Missense_Mutation_p.G602A|SEC14L1_ENST00000431431.2_Missense_Mutation_p.G568A|SEC14L1_ENST00000436233.4_Missense_Mutation_p.G602A	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	602	GOLD.				transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						TGGCAGCTGGGCCGCGACTAC	0.562000													30	108					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166231267	166231267	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166231267C>T	ENST00000357398.3	+	22	4335	c.4045C>T	c.(4045-4047)Cta>Tta	p.L1349L	SCN2A_ENST00000375427.2_Silent_p.L1349L|SCN2A_ENST00000283256.6_Silent_p.L1349L|SCN2A_ENST00000375437.2_Silent_p.L1349L			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1349					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GATCTTTTGGCTAATATTCAG	0.383000													34	34					0	0	1	0	0
CGGBP1	8545	broad.mit.edu	37	3	88104943	88104943	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:88104943G>A	ENST00000398392.2	-	1	1516	c.184C>T	c.(184-186)Ctc>Ttc	p.L62F	CGGBP1_ENST00000309534.6_Missense_Mutation_p.L62F|CGGBP1_ENST00000482016.1_Missense_Mutation_p.L62F|CGGBP1_ENST00000462901.1_Missense_Mutation_p.L62F			Q9UFW8	CGBP1_HUMAN	CGG triplet repeat binding protein 1	62					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding			kidney(1)|large_intestine(2)|lung(2)	5		Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00359)|Lung(72;0.00677)		TTTGACTTGAGGTGGTCACTA	0.458000													28	56					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111726774	111726774	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:111726774G>A	ENST00000435970.1	-	6	1046	c.230C>T	c.(229-231)gCg>gTg	p.A77V	REV3L_ENST00000358835.3_Missense_Mutation_p.A155V|REV3L_ENST00000368805.1_Missense_Mutation_p.A155V|REV3L_ENST00000368802.3_Missense_Mutation_p.A155V			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	155					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GGGAATATGCGCTTCATGAGG	0.343000								DNA polymerases (catalytic subunits)					41	60					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72903642	72903642	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:72903642C>T	ENST00000339594.4	-	6	1111	c.773G>A	c.(772-774)cGg>cAg	p.R258Q	BAZ1B_ENST00000404251.1_Missense_Mutation_p.R258Q	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	258	Mediates the tyrosine-protein kinase activity.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				TGCATTATGCCGTATAAAGTA	0.423000													29	58					0	0	1	0	0
GALNS	2588	broad.mit.edu	37	16	88902227	88902227	+	Missense_Mutation	SNP	G	G	A	rs146963745		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:88902227G>A	ENST00000268695.5	-	7	752	c.664C>T	c.(664-666)Cgg>Tgg	p.R222W	GALNS_ENST00000542788.1_Missense_Mutation_p.R147W	NM_000512.4	NP_000503.1	P34059	GALNS_HUMAN	galactosamine (N-acetyl)-6-sulfate sulfatase	222						lysosome	metal ion binding|N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(8)	22				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	GGGTGGTGCCGTGCCTGTCTC	0.627000													8	31					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13381471	13381471	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:13381471G>A	ENST00000254508.5	-	25	3436	c.3354C>T	c.(3352-3354)agC>agT	p.S1118S	NUP210_ENST00000485755.1_5'UTR	NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1118					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CCAGCGCAACGCTCTCATTGC	0.652000													39	47					0	0	1	0	0
NIPAL3	57185	broad.mit.edu	37	1	24768584	24768584	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24768584C>T	ENST00000358028.4	+	4	551	c.202C>T	c.(202-204)Cgg>Tgg	p.R68W	NIPAL3_ENST00000374399.4_Missense_Mutation_p.R68W|NIPAL3_ENST00000003912.3_5'UTR|NIPAL3_ENST00000339255.2_Missense_Mutation_p.R68W|NIPAL3_ENST00000428131.1_Missense_Mutation_p.R68W			Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	68						integral to membrane				endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(1)	14						CAAGGATCCCCGGGCCTATTT	0.537000													22	20					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4709136	4709136	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:4709136G>A	ENST00000302640.8	+	17	2094	c.1744G>A	c.(1744-1746)Gcc>Acc	p.A582T	ITPR1_ENST00000443694.2_Missense_Mutation_p.A582T|ITPR1_ENST00000456211.2_Missense_Mutation_p.A582T|ITPR1_ENST00000423119.2_Missense_Mutation_p.A597T|ITPR1_ENST00000354582.6_Missense_Mutation_p.A597T|ITPR1_ENST00000357086.4_Missense_Mutation_p.A597T|ITPR1_ENST00000544951.1_Intron	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	597					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CACTATCACTGCCCTGCTCCA	0.473000													13	16					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	981376	981376	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:981376C>T	ENST00000379370.2	+	16	2763	c.2713C>T	c.(2713-2715)Cgc>Tgc	p.R905C		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	905					axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		TGCGGAGATGCGCTGTGAGTT	0.667000													8	28					0	0	1	0	0
CDC37	11140	broad.mit.edu	37	19	10506866	10506866	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10506866C>T	ENST00000222005.2	-	2	169	c.116G>A	c.(115-117)cGc>cAc	p.R39H		NM_007065.3	NP_008996.1	Q16543	CDC37_HUMAN	cell division cycle 37	39					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	16			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		CTGCTCCATGCGTTCCACCCG	0.647000													23	42					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55191836	55191836	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:55191836G>A	ENST00000337714.3	+	6	2353	c.2120G>A	c.(2119-2121)gGc>gAc	p.G707D	AKAP1_ENST00000572557.1_Missense_Mutation_p.G707D|AKAP1_ENST00000571629.1_Missense_Mutation_p.G707D|AKAP1_ENST00000539273.1_Missense_Mutation_p.G707D	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	707					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					CTGCCTGATGGCATCACCGTG	0.567000											OREG0024595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	23					0	0	1	0	0
MTMR14	64419	broad.mit.edu	37	3	9739506	9739506	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9739506C>A	ENST00000296003.4	+	18	1847	c.1725C>A	c.(1723-1725)tcC>tcA	p.S575S	MTMR14_ENST00000353332.5_Intron|MTMR14_ENST00000420925.1_Intron|MTMR14_ENST00000351233.5_Intron	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	575						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					ACACAGACTCCTCTCTCCCTT	0.572000													103	135					2.41565e-62	2.71757e-62	1	1	0
CUL9	23113	broad.mit.edu	37	6	43160785	43160785	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43160785G>A	ENST00000252050.4	+	9	2311	c.2227G>A	c.(2227-2229)Gga>Aga	p.G743R	CUL9_ENST00000372647.2_Missense_Mutation_p.G743R|CUL9_ENST00000354495.3_Missense_Mutation_p.G633R	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	743					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						CAACCAGGTGGGAGAGAAGAT	0.582000													28	88					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154492814	154492814	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154492814C>A	ENST00000368482.4	+	5	1014	c.176C>A	c.(175-177)cCt>cAt	p.P59H	TDRD10_ENST00000368480.3_Missense_Mutation_p.P59H	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	59	RRM.						nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GACTTCAACCCTCTTGATGTC	0.423000													11	58					2.68362e-12	2.90084e-12	1	1	0
ACTN4	81	broad.mit.edu	37	19	39220008	39220008	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39220008C>T	ENST00000252699.2	+	21	2748	c.2672C>T	c.(2671-2673)gCc>gTc	p.A891V	ACTN4_ENST00000497637.1_3'UTR|ACTN4_ENST00000390009.3_Missense_Mutation_p.A672V|ACTN4_ENST00000424234.2_Missense_Mutation_p.A501V	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	891				AVP -> GVR (in Ref. 3; AAC17470).	platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGCCCTGACGCCGTGCCCGGT	0.667000													11	17					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57603498	57603498	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57603498G>A	ENST00000243077.3	+	80	12752	c.12286G>A	c.(12286-12288)Gac>Aac	p.D4096N		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	4096					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTTCAGCATCGACGTCTTTGA	0.562000													9	12					0	0	1	0	0
MRPL23	6150	broad.mit.edu	37	11	1973409	1973409	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:1973409G>A	ENST00000381514.3	+	3	215	c.193G>A	c.(193-195)Gtg>Atg	p.V65M	MRPL23_ENST00000397294.3_Missense_Mutation_p.V65M|MRPL23_ENST00000397297.3_Missense_Mutation_p.V65M|MRPL23_ENST00000397298.3_Missense_Mutation_p.V65M|MRPL23_ENST00000381519.1_Missense_Mutation_p.V65M			Q16540	RM23_HUMAN	mitochondrial ribosomal protein L23	65					translation	mitochondrial large ribosomal subunit	nucleotide binding|RNA binding|structural constituent of ribosome			large_intestine(2)|lung(1)|ovary(1)	4		all_epithelial(84;6.24e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.0026)|Lung(200;0.0171)|LUSC - Lung squamous cell carcinoma(625;0.0842)		TAACGTGCCCGTGGCTGCTGT	0.582000													9	14					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162622177	162622177	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:162622177G>A	ENST00000366898.1	-	4	622	c.520C>T	c.(520-522)Ctc>Ttc	p.L174F	PARK2_ENST00000366892.1_Missense_Mutation_p.L174F|PARK2_ENST00000338468.3_Intron|PARK2_ENST00000366897.1_Missense_Mutation_p.L174F|PARK2_ENST00000366896.1_Intron|PARK2_ENST00000366894.1_5'UTR	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	174					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		GTCAAGGTGAGCGTTGCCTGC	0.463000													25	31					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196865487	196865487	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:196865487C>T	ENST00000312428.6	-	12	1394	c.1294G>A	c.(1294-1296)Gtc>Atc	p.V432I	DNAH7_ENST00000410072.1_Missense_Mutation_p.V432I	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	432	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTAATCATGACGTCATAAACA	0.338000													5	202					0	0	1	0	0
GBX1	2636	broad.mit.edu	37	7	150845879	150845879	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150845879C>T	ENST00000297537.4	-	2	888	c.889G>A	c.(889-891)Gcc>Acc	p.A297T		NM_001098834.1	NP_001092304.1	Q14549	GBX1_HUMAN	gastrulation brain homeobox 1	297						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(5)|skin(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCTTGAGGGCGTGGGCGATC	0.537000													16	43					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67270021	67270021	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67270021G>A	ENST00000356404.3	-	3	472	c.247C>T	c.(247-249)Cag>Tag	p.Q83*	PITPNM1_ENST00000436757.2_Nonsense_Mutation_p.Q83*|PITPNM1_ENST00000534749.1_Nonsense_Mutation_p.Q83*	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	83					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						TCTTCTACCTGCAGGGCAGCC	0.667000													19	23					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46771921	46771921	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:46771921C>T	ENST00000394809.4	-	3	818	c.703G>A	c.(703-705)Gca>Aca	p.A235T	MYLK3_ENST00000536476.1_Intron	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	235					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CCAGGGAATGCCTGGGCTGGG	0.672000													10	15					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9583864	9583864	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9583864C>A	ENST00000301480.4	-	5	442	c.229G>T	c.(229-231)Gtt>Ttt	p.V77F		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	77	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						CCTTGGAGAACTCCTTGCTGC	0.388000													63	105					3.33906e-19	3.69312e-19	1	1	0
ZNF768	79724	broad.mit.edu	37	16	30536159	30536159	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30536159G>A	ENST00000380412.5	-	2	1477	c.1302C>T	c.(1300-1302)tgC>tgT	p.C434C	ZNF768_ENST00000562803.1_Silent_p.C403C	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	434					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						AGCGCTTGCCGCACTCAGGGC	0.672000													7	9					0	0	1	0	0
ZFX	7543	broad.mit.edu	37	X	24229488	24229488	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:24229488C>T	ENST00000379177.1	+	11	2840	c.2413C>T	c.(2413-2415)Ccc>Tcc	p.P805S	ZFX_ENST00000379188.3_Missense_Mutation_p.P805S|ZFX_ENST00000539115.1_Missense_Mutation_p.P576S|ZFX_ENST00000338565.3_Missense_Mutation_p.P755S|ZFX_ENST00000540034.1_Missense_Mutation_p.P844S|ZFX_ENST00000304543.5_Missense_Mutation_p.P805S	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	805					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						AGTTGGCCTGCCCTAACAATA	0.398000													19	3					0	0	1	0	0
EFNB2	1948	broad.mit.edu	37	13	107145456	107145456	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:107145456C>T	ENST00000245323.4	-	5	1083	c.934G>A	c.(934-936)Ggg>Agg	p.G312R		NM_004093.3	NP_004084.1	P52799	EFNB2_HUMAN	ephrin-B2	312					cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					ACCGGGTGCCCGTAGTCGCCG	0.597000													18	19					0	0	1	0	0
IL21	59067	broad.mit.edu	37	4	123534004	123534004	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:123534004A>G	ENST00000264497.3	-	4	496		c.e4+1			NM_001207006.2|NM_021803.3	NP_001193935.1|NP_068575.1	Q9HBE4	IL21_HUMAN	interleukin 21						cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(3)	8						TAAGGTAGATACCTTTTGGAG	0.333000													7	26					0	0	1	0	0
SLC29A3	55315	broad.mit.edu	37	10	73103989	73103989	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:73103989C>T	ENST00000373189.5	+	3	376	c.324C>T	c.(322-324)gcC>gcT	p.A108A		NM_001174098.1|NM_018344.5	NP_001167569.1|NP_060814.4	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 3	108					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	15						GCTACCTTGCCGTTGCCTCCA	0.592000													4	73					0	0	1	0	0
OR2S2	56656	broad.mit.edu	37	9	35957181	35957181	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35957181C>A	ENST00000341959.2	-	1	970	c.915G>T	c.(913-915)aaG>aaT	p.K305N		NM_019897.2	NP_063950.2	Q9NQN1	OR2S1_HUMAN	olfactory receptor, family 2, subfamily S, member 2	305					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(32;0.00613)|STAD - Stomach adenocarcinoma(86;0.194)			TCACAGCAGCCTTCACATCCT	0.493000													35	46					4.46736e-08	4.70435e-08	1	1	0
NCL	4691	broad.mit.edu	37	2	232321455	232321455	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:232321455G>A	ENST00000322723.4	-	11	1832	c.1592C>T	c.(1591-1593)gCt>gTt	p.A531V		NM_005381.2	NP_005372.2	P19338	NUCL_HUMAN	nucleolin	531	RRM 3.				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(3)	35		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		TTCGAATGAAGCAAACTCTAT	0.448000													26	46					0	0	1	0	0
NTSR1	4923	broad.mit.edu	37	20	61340858	61340858	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:61340858C>T	ENST00000370501.3	+	1	670	c.299C>T	c.(298-300)aCg>aTg	p.T100M		NM_002531.2	NP_002522.2	P30989	NTR1_HUMAN	neurotensin receptor 1 (high affinity)	100						endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(16)|prostate(1)|skin(3)	27	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CTGCAGAGCACGGTGCATTAC	0.662000													6	16					0	0	1	0	0
FZD5	7855	broad.mit.edu	37	2	208631738	208631738	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:208631738A>G	ENST00000295417.3	-	2	2279	c.1726T>C	c.(1726-1728)Tac>Cac	p.Y576H		NM_003468.3	NP_003459.2	Q13467	FZD5_HUMAN	frizzled family receptor 5	576					angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			NS(1)|kidney(1)|lung(1)|ovary(2)|prostate(1)|skin(1)	7				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		TGCTTGTGGTAGGTggcggcg	0.726000													5	33					0	0	1	0	0
HECTD3	79654	broad.mit.edu	37	1	45475738	45475738	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:45475738A>G	ENST00000372172.4	-	4	750	c.679T>C	c.(679-681)Tat>Cat	p.Y227H		NM_024602.5	NP_078878.3	Q5T447	HECD3_HUMAN	HECT domain containing E3 ubiquitin protein ligase 3	227	DOC.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|stomach(1)	28	Acute lymphoblastic leukemia(166;0.155)					AGGTGGTCATACAAGAAGTGG	0.572000													19	23					0	0	1	0	0
DERA	51071	broad.mit.edu	37	12	16109906	16109906	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:16109906C>T	ENST00000428559.2	+	2	280	c.68C>T	c.(67-69)cCg>cTg	p.P23L	DERA_ENST00000532964.1_Missense_Mutation_p.P23L|DERA_ENST00000526530.1_5'UTR	NM_015954.2	NP_057038.2	Q9Y315	DEOC_HUMAN	deoxyribose-phosphate aldolase (putative)	23					deoxyribonucleoside catabolic process|deoxyribonucleotide catabolic process	cytoplasm	deoxyribose-phosphate aldolase activity|protein binding			endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		Hepatocellular(102;0.121)				GTGAATCACCCGGCAGTTCTG	0.418000													6	19					0	0	1	0	0
EFHD1	80303	broad.mit.edu	37	2	233498631	233498631	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:233498631C>T	ENST00000264059.3	+	1	694	c.217C>T	c.(217-219)Cgg>Tgg	p.R73W	EFHD1_ENST00000409613.1_Intron	NM_025202.3	NP_079478.1	Q9BUP0	EFHD1_HUMAN	EF-hand domain family, member D1	73							calcium ion binding|protein binding			NS(1)|breast(1)|large_intestine(2)|lung(3)	7		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Breast(86;0.0199)|Renal(207;0.025)		Epithelial(121;2.08e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00825)|Lung(119;0.0101)		TGCGCGGCCCCGGCGCTGCAG	0.711000													4	8					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79750157	79750157	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:79750157C>T	ENST00000305428.3	+	2	1743	c.1668C>T	c.(1666-1668)tgC>tgT	p.C556C		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	556						integral to membrane		p.C556>?(1)		central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						AGTCAGACTGCGACAGTTCCC	0.527000													14	18					0	0	1	0	0
WDR62	284403	broad.mit.edu	37	19	36557276	36557276	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36557276A>G	ENST00000401500.2	+	5	543	c.508A>G	c.(508-510)Atc>Gtc	p.I170V	WDR62_ENST00000270301.7_Missense_Mutation_p.I170V|WDR62_ENST00000388999.3_Missense_Mutation_p.I170V|WDR62_ENST00000378860.4_3'UTR	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	170					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TATGAAGCACATCGTGTCCAT	0.577000													3	2					0	0	1	0	0
ENPP7	339221	broad.mit.edu	37	17	77709383	77709383	+	Missense_Mutation	SNP	C	C	T	rs148221256	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:77709383C>T	ENST00000328313.5	+	3	1162	c.941C>T	c.(940-942)gCg>gTg	p.A314V		NM_178543.3	NP_848638.2	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 7	314					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(6)|skin(3)	34			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			AAGAAGGAGGCGTTCCCCGAG	0.607000													5	22					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108185257	108185257	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:108185257T>C	ENST00000370056.4	-	20	2172	c.1898A>G	c.(1897-1899)cAc>cGc	p.H633R	VAV3_ENST00000415432.2_Missense_Mutation_p.H73R|VAV3_ENST00000544443.1_Missense_Mutation_p.H37R|VAV3_ENST00000527011.1_Missense_Mutation_p.H633R|VAV3_ENST00000343258.4_5'UTR	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	633	SH3 1.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		AAACAGACTGTGTGCATCTCC	0.517000													17	20					0	0	1	0	0
ARID5A	10865	broad.mit.edu	37	2	97216925	97216925	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:97216925C>T	ENST00000454558.2	+	7	1633	c.456C>T	c.(454-456)ggC>ggT	p.G152G	ARID5A_ENST00000357485.3_Silent_p.G220G			Q03989	ARI5A_HUMAN	AT rich interactive domain 5A (MRF1-like)	220					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						AACAGCAGGGCCTGGCCTCTG	0.597000													17	37					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101906538	101906538	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:101906538C>A	ENST00000348070.1	-	14	1718		c.e14-1		PCSK6_ENST00000331826.7_Splice_Site|PCSK6_ENST00000358417.3_Splice_Site|PCSK6_ENST00000561177.1_Splice_Site|PCSK6_ENST00000344273.2_Splice_Site|PCSK6_ENST00000398181.2_Splice_Site	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6						glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATCCAGCAACCTGCAATTGGA	0.542000													12	20					7.93312e-07	8.27737e-07	1	1	0
DOPEY1	23033	broad.mit.edu	37	6	83848608	83848608	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:83848608A>G	ENST00000349129.2	+	21	5107	c.4847A>G	c.(4846-4848)cAc>cGc	p.H1616R	DOPEY1_ENST00000237163.5_Missense_Mutation_p.H1597R|DOPEY1_ENST00000484282.1_3'UTR|DOPEY1_ENST00000369739.3_Missense_Mutation_p.H1607R	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1616					protein transport			p.H1616R(1)		breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		GACTTAGAACACATCAGTCCC	0.418000													28	78					0	0	1	0	0
MSX1	4487	broad.mit.edu	37	4	4864847	4864847	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:4864847T>C	ENST00000382723.4	+	2	1123	c.889T>C	c.(889-891)Tac>Cac	p.Y297H		NM_002448.3	NP_002439.2	P28360	MSX1_HUMAN	msh homeobox 1	291					apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCATGTGGGCTACAGCATGTA	0.701000													5	2					0	0	1	0	0
CLINT1	9685	broad.mit.edu	37	5	157214774	157214774	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:157214774G>A	ENST00000523094.1	-	12	1963	c.1758C>T	c.(1756-1758)tcC>tcT	p.S586S	CLINT1_ENST00000523908.1_Silent_p.S604S|CLINT1_ENST00000296951.5_Silent_p.S586S|CLINT1_ENST00000411809.2_Silent_p.S586S|CLINT1_ENST00000530742.1_Silent_p.S586S	NM_001195555.1|NM_001195556.1	NP_001182484.1|NP_001182485.1	Q14677	EPN4_HUMAN	clathrin interactor 1	586	Met-rich.				endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|urinary_tract(1)	21	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCCCAGCAGCGGACATCCCTA	0.512000													33	74					0	0	1	0	0
PCDHA5	0	broad.mit.edu	37	5	140203117	140203117	+	Missense_Mutation	SNP	C	C	T	rs138704270		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140203117C>T	ENST00000529859.1	+	1	1757	c.1757C>T	c.(1756-1758)gCg>gTg	p.A586V	PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.A586V|PCDHA5_ENST00000529619.1_Missense_Mutation_p.A586V|PCDHA2_ENST00000526136.1_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGTGGGTGCGGGCCACGTG	0.682000													24	34					0	0	1	0	0
COBLL1	22837	broad.mit.edu	37	2	165550911	165550911	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:165550911C>A	ENST00000375458.2	-	11	3212	c.2991G>T	c.(2989-2991)caG>caT	p.Q997H	COBLL1_ENST00000194871.6_Missense_Mutation_p.Q1102H|COBLL1_ENST00000392717.2_Missense_Mutation_p.Q1073H|COBLL1_ENST00000409184.3_Missense_Mutation_p.Q1035H|COBLL1_ENST00000342193.4_Missense_Mutation_p.Q1035H	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	1073										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						TACTGAAAGACTGTGACCTTT	0.463000													25	31					4.7796e-09	5.06125e-09	1	1	0
NAA15	80155	broad.mit.edu	37	4	140264115	140264115	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:140264115G>A	ENST00000296543.5	+	5	860		c.e5+1		NAA15_ENST00000480277.2_Splice_Site|NAA15_ENST00000398947.1_Splice_Site	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit						angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						AACACAACAGGTAATAACTAG	0.303000													14	16					0	0	1	0	0
NOD1	10392	broad.mit.edu	37	7	30469004	30469004	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:30469004G>A	ENST00000222823.4	-	13	3300	c.2775C>T	c.(2773-2775)ggC>ggT	p.G925G		NM_006092.2	NP_006083.1	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain containing 1	925					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						TCTCTGTTATGCCAGTGTTGC	0.468000													76	131					0	0	1	0	0
DOK3	79930	broad.mit.edu	37	5	176931272	176931272	+	Silent	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176931272C>G	ENST00000501403.2	-	6	1384	c.1035G>C	c.(1033-1035)ctG>ctC	p.L345L	DOK3_ENST00000312943.6_Intron|DOK3_ENST00000357198.4_Silent_p.L401L|DOK3_ENST00000377112.4_Intron			Q7L591	DOK3_HUMAN	docking protein 3	401	Pro-rich.					cytoplasm|plasma membrane	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|lung(7)	13	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			CCAGCACACACAGGTTCTCAT	0.667000													3	1					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42144411	42144411	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42144411C>T	ENST00000320955.6	-	62	10780	c.10553G>A	c.(10552-10554)gGa>gAa	p.G3518E		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3518					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CAGCTGTGCTCCTAGCCCCTG	0.672000													11	12					0	0	1	0	0
DDX18	8886	broad.mit.edu	37	2	118582239	118582239	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:118582239C>T	ENST00000263239.2	+	8	1289	c.1161C>T	c.(1159-1161)ggC>ggT	p.G387G		NM_006773.3	NP_006764.3	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	387							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TGTATGTTGGCGTTGATGATG	0.398000													52	81					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27539921	27539921	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:27539921T>C	ENST00000356183.4	-	6	986	c.971A>G	c.(970-972)aAa>aGa	p.K324R	GTF3C1_ENST00000561623.1_Missense_Mutation_p.K324R	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	324						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						TGCATTACCTTTCTTTGTCTT	0.502000													25	42					0	0	1	0	0
PPM1A	5494	broad.mit.edu	37	14	60749508	60749508	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:60749508G>A	ENST00000395076.4	+	2	517	c.87G>A	c.(85-87)atG>atA	p.M29I	PPM1A_ENST00000325642.3_Missense_Mutation_p.M102I|PPM1A_ENST00000529574.1_Missense_Mutation_p.M29I|PPM1A_ENST00000325658.3_Missense_Mutation_p.M29I	NM_021003.4	NP_066283.1	P35813	PPM1A_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1A	29					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			cervix(1)|endometrium(1)|large_intestine(8)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.046)		TAAGCAGCATGCAAGGCTGGC	0.483000													7	192					0	0	1	0	0
PLEKHA4	0	broad.mit.edu	37	19	49363659	49363659	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49363659G>A	ENST00000263265.6	-	6	979	c.424C>T	c.(424-426)Cgg>Tgg	p.R142W	PLEKHA4_ENST00000355496.5_Missense_Mutation_p.R142W	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	142	PH.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		AGCCAGCCCCGCAGGTCTTCT	0.652000													29	45					0	0	1	0	0
WDHD1	11169	broad.mit.edu	37	14	55474015	55474015	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:55474015G>A	ENST00000360586.3	-	7	648	c.583C>T	c.(583-585)Cag>Tag	p.Q195*	WDHD1_ENST00000421192.1_Nonsense_Mutation_p.Q72*|WDHD1_ENST00000420358.2_Nonsense_Mutation_p.Q72*	NM_007086.3	NP_009017.1	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	195						cytoplasm|nucleoplasm	DNA binding			breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(2)	42						CTTTTTGGCTGCCAAGCAAGT	0.338000													16	42					0	0	1	0	0
UBALD1	124402	broad.mit.edu	37	16	4659782	4659782	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4659782G>A	ENST00000590891.1	-	1	1742	c.491C>T	c.(490-492)tCg>tTg	p.S164L	UBALD1_ENST00000587615.1_Missense_Mutation_p.S104L|UBALD1_ENST00000591401.1_Missense_Mutation_p.S108L|UBALD1_ENST00000591897.1_Missense_Mutation_p.S69L|UBALD1_ENST00000590965.1_3'UTR|UBALD1_ENST00000587649.1_3'UTR|UBALD1_ENST00000283474.7_Missense_Mutation_p.S129L					UBA-like domain containing 1																		CCCCGGGGGCGAGGCCGCCGT	0.741000													5	6					0	0	1	0	0
PIK3R5	23533	broad.mit.edu	37	17	8791557	8791557	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8791557G>A	ENST00000447110.1	-	10	1671	c.1547C>T	c.(1546-1548)aCg>aTg	p.T516M	PIK3R5_ENST00000581552.1_Missense_Mutation_p.T516M|PIK3R5_ENST00000584803.1_Missense_Mutation_p.T516M	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	516					platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						AACACGTAGCGTGGAAGCCTT	0.622000													38	47					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69519894	69519894	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:69519894C>T	ENST00000338206.5	-	5	1183	c.1174G>A	c.(1174-1176)Gtg>Atg	p.V392M		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	392					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										GGAATGCCCACCATAGGGATC	0.458000													62	92					0	0	1	0	0
SERPINI1	5274	broad.mit.edu	37	3	167508391	167508391	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:167508391G>A	ENST00000295777.5	+	3	912		c.e3+1		SERPINI1_ENST00000446050.2_Splice_Site	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1						central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						AACACAAACAGTATGTCACTT	0.353000													11	13					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50402359	50402359	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50402359T>C	ENST00000435965.1	-	38	3454	c.3281A>G	c.(3280-3282)tAc>tGc	p.Y1094C	CACNA2D2_ENST00000360963.3_Missense_Mutation_p.Y1017C|CACNA2D2_ENST00000395083.1_Missense_Mutation_p.Y1087C|XXcos-LUCA11.5_ENST00000606589.1_Intron|CACNA2D2_ENST00000423994.2_Missense_Mutation_p.Y1094C|CACNA2D2_ENST00000479441.1_Missense_Mutation_p.Y1091C|CACNA2D2_ENST00000429770.1_Missense_Mutation_p.Y1085C|CACNA2D2_ENST00000266039.3_Missense_Mutation_p.Y1086C|CACNA2D2_ENST00000424201.2_Missense_Mutation_p.Y1084C			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	1091					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	GCCTCTCCGGTATCGCGGTCT	0.716000													9	18					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1461079	1461079	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1461079T>C	ENST00000535453.1	+	12	3278	c.1565T>C	c.(1564-1566)aTc>aCc	p.I522T	CTB-25B13.12_ENST00000588225.1_RNA|APC2_ENST00000233607.2_Missense_Mutation_p.I522T|APC2_ENST00000238483.4_Missense_Mutation_p.I248T			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	522					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGCCGACATCAACAGCAAG	0.672000													35	63					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100144810	100144810	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:100144810G>A	ENST00000370575.4	-	15	1617	c.1569C>T	c.(1567-1569)tgC>tgT	p.C523C	PYROXD2_ENST00000483923.1_5'UTR	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	523							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						GGGACATGGCGCAGTGGAATA	0.607000													12	25					0	0	1	0	0
MASP2	10747	broad.mit.edu	37	1	11090891	11090891	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11090891T>C	ENST00000400897.3	-	9	1151	c.1136A>G	c.(1135-1137)tAc>tGc	p.Y379C		NM_006610.3	NP_006601.2	O00187	MASP2_HUMAN	mannan-binding lectin serine peptidase 2	379	Sushi 2.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			biliary_tract(1)|endometrium(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		ACCTGTGATGTACTCCACTCG	0.458000													18	20					0	0	1	0	0
PDDC1	347862	broad.mit.edu	37	11	771350	771350	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:771350G>A	ENST00000319863.8	-	6	548	c.527C>T	c.(526-528)tCg>tTg	p.S176L	PDDC1_ENST00000529966.1_5'UTR|PDDC1_ENST00000524550.1_Missense_Mutation_p.S140L|PDDC1_ENST00000397472.2_Missense_Mutation_p.S176L|PDDC1_ENST00000442059.2_Missense_Mutation_p.S126L|PDDC1_ENST00000526325.1_3'UTR	NM_182612.2	NP_872418.1	Q8NB37	PDDC1_HUMAN	Parkinson disease 7 domain containing 1	176						extracellular region				kidney(1)|lung(3)|urinary_tract(1)	5		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;3.66e-26)|Epithelial(43;2.43e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-19)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCAGGCGCCCGAATCCTTCAC	0.697000													10	9					0	0	1	0	0
CUTC	51076	broad.mit.edu	37	10	101499521	101499521	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:101499521G>A	ENST00000370476.5	+	3	317	c.188G>A	c.(187-189)aGc>aAc	p.S63N	CUTC_ENST00000493385.1_3'UTR	NM_015960.2	NP_057044.2	Q9NTM9	CUTC_HUMAN	cutC copper transporter	63					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		ACTACACCCAGCATGGGTAAG	0.398000													42	53					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131394422	131394422	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131394422T>G	ENST00000372739.3	+	53	6889	c.6779T>G	c.(6778-6780)aTc>aGc	p.I2260S	SPTAN1_ENST00000358161.5_Missense_Mutation_p.I2260S|SPTAN1_ENST00000372731.4_Missense_Mutation_p.I2255S	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2255					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						CACCAGGAAATCCGAGCCATG	0.617000													6	12					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104836887	104836887	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:104836887G>C	ENST00000369878.3	+	8	2702	c.2578G>C	c.(2578-2580)Gtg>Ctg	p.V860L	CNNM2_ENST00000457502.2_Missense_Mutation_p.V618L|CNNM2_ENST00000433628.2_Missense_Mutation_p.V838L	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	860					ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ACAGAACTGTGTGACGCACAG	0.597000													20	32					0	0	1	0	0
ATF6B	1388	broad.mit.edu	37	6	32087657	32087657	+	Silent	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32087657T>G	ENST00000375201.4	-	9	946	c.901A>C	c.(901-903)Agg>Cgg	p.R301R	ATF6B_ENST00000375203.3_Silent_p.R304R			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	304					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						ATGCTCTTCCTCTCAGGCCGT	0.597000													9	19					0	0	1	0	0
AHI1	54806	broad.mit.edu	37	6	135769461	135769461	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:135769461G>A	ENST00000367800.4	-	10	1809	c.1593C>T	c.(1591-1593)taC>taT	p.Y531Y	AHI1_ENST00000457866.2_Silent_p.Y531Y|AHI1_ENST00000327035.6_Silent_p.Y531Y	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	531						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TTACAGTTACGTACAGTGTTG	0.363000													8	16					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55729233	55729233	+	Missense_Mutation	SNP	G	G	A	rs5565		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:55729233G>A	ENST00000379906.2	+	7	1321	c.1066G>A	c.(1066-1068)Gtc>Atc	p.V356I	SLC6A2_ENST00000568943.1_Missense_Mutation_p.V356I|SLC6A2_ENST00000566163.1_Missense_Mutation_p.V311I|SLC6A2_ENST00000567238.1_Missense_Mutation_p.V251I|SLC6A2_ENST00000219833.8_Missense_Mutation_p.V356I|SLC6A2_ENST00000414754.3_Missense_Mutation_p.V356I|SLC6A2_ENST00000561820.1_Missense_Mutation_p.V356I	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	356			V -> L (in dbSNP:rs5565).		synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	CACCAGCTTCGTCTCTGGGTT	0.552000													34	32					0	0	1	0	0
ZBED4	9889	broad.mit.edu	37	22	50279587	50279587	+	Silent	SNP	G	G	A	rs113510025		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50279587G>A	ENST00000216268.4	+	2	2754	c.2277G>A	c.(2275-2277)ccG>ccA	p.P759P		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	759						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CAGCCCGGCCGCGCTGTGACG	0.607000													4	16					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61511050	61511050	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61511050C>T	ENST00000257215.5	+	20	2334	c.2218C>T	c.(2218-2220)Cgg>Tgg	p.R740W		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	740					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		CTCGGAGGGGCGGCTGCTGTC	0.687000													7	97					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116692112	116692112	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:116692112C>T	ENST00000357780.3	-	3	776	c.662G>A	c.(661-663)cGc>cAc	p.R221H		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		AGCCAGGCTGCGGCGCAGCTC	0.592000													61	93					0	0	1	0	0
TRIM2	23321	broad.mit.edu	37	4	154216729	154216729	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:154216729G>A	ENST00000338700.5	+	6	1116	c.1051G>A	c.(1051-1053)Gtt>Att	p.V351I	TRIM2_ENST00000437508.2_Missense_Mutation_p.V324I|TRIM2_ENST00000494872.1_3'UTR	NM_015271.3	NP_056086.2	Q9C040	TRIM2_HUMAN	tripartite motif containing 2	324						cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)	19	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		CACCAACGCCGTTGCCTCAGA	0.607000													13	12					0	0	1	0	0
DCST2	127579	broad.mit.edu	37	1	155005967	155005967	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155005967C>T	ENST00000368424.3	-	1	269	c.211G>A	c.(211-213)Gga>Aga	p.G71R	DCST2_ENST00000295536.5_Missense_Mutation_p.G71R	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	71						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CGAGAGAATCCCATGCCCAGG	0.662000													15	34					0	0	1	0	0
ASNSD1	54529	broad.mit.edu	37	2	190531702	190531702	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190531702G>A	ENST00000260952.4	+	4	1257	c.844G>A	c.(844-846)Gta>Ata	p.V282I	ASNSD1_ENST00000607062.1_Intron	NM_019048.2	NP_061921.1	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	282					asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(3)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			CATGAAGGAAGTAATTCAGCA	0.403000													49	79					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169626362	169626362	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:169626362G>A	ENST00000366787.3	-	17	2700	c.2451C>T	c.(2449-2451)taC>taT	p.Y817Y	XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	817					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity	p.Y817Y(1)		NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TGTTGTAGACGTAGGGACAAT	0.502000													18	33					0	0	1	0	0
ADH1A	124	broad.mit.edu	37	4	100208060	100208060	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:100208060T>A	ENST00000209668.2	-	3	319	c.206A>T	c.(205-207)gAg>gTg	p.E69V	RP11-696N14.1_ENST00000500358.2_RNA|ADH1A_ENST00000511656.1_5'UTR	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	69					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	GCCGGCTGCCTCATGGCCTAA	0.502000													51	71					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890683	229890683	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:229890683G>A	ENST00000392054.3	-	4	751	c.412C>T	c.(412-414)Cca>Tca	p.P138S	PID1_ENST00000409462.1_Missense_Mutation_p.P58S|PID1_ENST00000392055.3_Missense_Mutation_p.P107S|PID1_ENST00000482518.2_Intron|PID1_ENST00000354069.6_Missense_Mutation_p.P140S	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	140	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		ACTTGGAATGGCCGGATTTCC	0.572000													3	33					0	0	1	0	0
CLOCK	9575	broad.mit.edu	37	4	56336952	56336952	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:56336952C>T	ENST00000309964.4	-	7	620	c.370G>A	c.(370-372)Gca>Aca	p.A124T	CLOCK_ENST00000381322.1_Missense_Mutation_p.A124T|CLOCK_ENST00000513440.1_Missense_Mutation_p.A124T	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	124	PAS 1.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			GTCATGATTGCTAAAAAAAAA	0.284000													30	74					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	30959709	30959709	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:30959709G>T	ENST00000399914.1	-	11	2246	c.1725C>A	c.(1723-1725)agC>agA	p.S575R	GRIK1_ENST00000389125.3_Missense_Mutation_p.S575R|GRIK1_ENST00000399913.1_Missense_Mutation_p.S590R|GRIK1_ENST00000535441.1_Missense_Mutation_p.S592R|GRIK1_ENST00000327783.4_Missense_Mutation_p.S590R|GRIK1_ENST00000399909.1_Missense_Mutation_p.S575R|GRIK1_ENST00000389124.2_Missense_Mutation_p.S590R|GRIK1_ENST00000309434.7_Missense_Mutation_p.S592R|GRIK1_ENST00000399907.1_Missense_Mutation_p.S590R			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	590					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	AGAGTACACAGCTGACTCCCA	0.468000													6	8					3.59834e-05	3.7043e-05	1	1	0
PACS1	55690	broad.mit.edu	37	11	65960985	65960985	+	Missense_Mutation	SNP	G	G	A	rs115491121	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65960985G>A	ENST00000320580.4	+	2	418	c.385G>A	c.(385-387)Gtc>Atc	p.V129I		NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	129					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						GAAGAAACTCGTCATGCTAAA	0.463000													13	25					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433545	73433545	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:73433545G>A	ENST00000263666.4	-	10	2286	c.2172C>T	c.(2170-2172)agC>agT	p.S724S	PDZRN3_ENST00000535920.1_Silent_p.S446S|PDZRN3_ENST00000462146.2_Silent_p.S381S|PDZRN3_ENST00000466780.1_Silent_p.S381S|PDZRN3_ENST00000479530.1_Silent_p.S441S	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	724							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TGCGGAAGCCGCTGTTGTGCA	0.607000													16	33					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28146975	28146975	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:28146975G>A	ENST00000302326.4	-	2	4845	c.3891C>T	c.(3889-3891)tcC>tcT	p.S1297S	MN1_ENST00000497225.1_5'UTR	NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	1297							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						AGGTGGGCACGGAGGCTCGAG	0.582000			T	ETV6	"""AML, meningioma"""								16	22					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96768374	96768374	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:96768374C>T	ENST00000359933.4	-	34	6002	c.5109G>A	c.(5107-5109)tcG>tcA	p.S1703S	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1703										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GCGGCATCAGCGACACTCTCA	0.458000													9	25					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35770907	35770907	+	Silent	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:35770907G>C	ENST00000187397.4	+	15	1794	c.1338G>C	c.(1336-1338)gtG>gtC	p.V446V	ARPP21_ENST00000444190.1_Silent_p.V392V|ARPP21_ENST00000337271.5_Silent_p.V392V|ARPP21_ENST00000417925.1_Silent_p.V412V|ARPP21_ENST00000458225.1_Silent_p.V412V	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	446						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						CAGGCTGTGTGCCTTATCCAG	0.607000													9	24					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37183047	37183047	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:37183047G>A	ENST00000274258.7	-	26	5466	c.1879C>T	c.(1879-1881)Ctg>Ttg	p.L627L	C5orf42_ENST00000508244.1_Silent_p.L1746L|C5orf42_ENST00000425232.2_Silent_p.L1746L			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1746										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CATTCCAGCAGTCTTCCTATA	0.378000													14	61					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154099885	154099885	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154099885C>T	ENST00000368559.3	-	9	1158	c.1087G>A	c.(1087-1089)Gtc>Atc	p.V363I	NUP210L_ENST00000271854.3_Missense_Mutation_p.V363I	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	363						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CCAGGTTGGACAGTGAAACCT	0.348000													14	29					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11118704	11118704	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:11118704C>T	ENST00000409790.1	+	13	1693	c.1463C>T	c.(1462-1464)gCg>gTg	p.A488V	CLEC16A_ENST00000465491.1_3'UTR|CLEC16A_ENST00000409552.3_Missense_Mutation_p.A470V	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	488								p.0?(1)		breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GTGTACCACGCGCTGGACAGC	0.537000													3	9					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36484378	36484378	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36484378C>T	ENST00000342292.4	-	11	5094	c.5074G>A	c.(5074-5076)Gat>Aat	p.D1692N	GPR179_ENST00000584976.1_5'UTR	NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	1692						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TCCTCCACATCCAAAGGGCAA	0.562000													4	86					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50154651	50154651	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50154651G>A	ENST00000360565.3	+	7	1129	c.1005G>A	c.(1003-1005)acG>acA	p.T335T		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	335					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		CCCCTGGAACGCCGCCCCAGG	0.701000													3	8					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46888394	46888394	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:46888394G>A	ENST00000359759.4	+	2	1611	c.1590G>A	c.(1588-1590)gcG>gcA	p.A530A	COL18A1_ENST00000400337.2_Silent_p.A115A|COL18A1_ENST00000355480.5_Silent_p.A295A			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	530	TSP N-terminal.				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CGGACTCGGCGCAGGCCATGG	0.632000													23	8					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145293504	145293504	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145293504G>T	ENST00000342960.5	+	1	134	c.99G>T	c.(97-99)caG>caT	p.Q33H	NBPF10_ENST00000369339.2_Missense_Mutation_p.Q33H|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	33										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGAAGAAACAGCAGTTCAGAA	0.488000													77	540					1.68508e-47	1.89485e-47	1	1	0
REPS1	85021	broad.mit.edu	37	6	139266738	139266738	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:139266738G>A	ENST00000450536.2	-	3	948	c.374C>T	c.(373-375)tCg>tTg	p.S125L	REPS1_ENST00000409812.2_Missense_Mutation_p.S125L|REPS1_ENST00000415951.2_Missense_Mutation_p.S125L|REPS1_ENST00000367663.4_Missense_Mutation_p.S125L|REPS1_ENST00000258062.5_Missense_Mutation_p.S125L			Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	125						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(2)	19				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		ACCAGAATACGACCCTTGATT	0.478000													74	92					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31578798	31578798	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:31578798T>C	ENST00000399332.1	-	36	6773	c.6285A>G	c.(6283-6285)atA>atG	p.I2095M	HECTD1_ENST00000553700.1_Missense_Mutation_p.I2095M	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	2095	K-box.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GTAACCATACTATTGCTCTGA	0.418000													12	12					0	0	1	0	0
AFG3L2	10939	broad.mit.edu	37	18	12351345	12351345	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:12351345C>T	ENST00000269143.3	-	11	1617	c.1386G>A	c.(1384-1386)gcG>gcA	p.A462A		NM_006796.2	NP_006787.2	Q9Y4W6	AFG32_HUMAN	AFG3-like AAA ATPase 2	462					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|prostate(3)|skin(1)|stomach(3)|urinary_tract(1)	27					Adenosine triphosphate(DB00171)	GCCTAAGCAGCGCGGGGTCCA	0.463000													11	26					0	0	1	0	0
FOXN4	121643	broad.mit.edu	37	12	109723126	109723126	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:109723126C>T	ENST00000299162.5	-	8	988	c.884G>A	c.(883-885)cGg>cAg	p.R295Q	FOXN4_ENST00000355216.1_Missense_Mutation_p.R115Q	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	295					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						GGCCATACTCCGGTGGATGGC	0.627000													3	10					0	0	1	0	0
GNPTAB	79158	broad.mit.edu	37	12	102158675	102158675	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:102158675G>A	ENST00000299314.7	-	13	2282	c.2020C>T	c.(2020-2022)Cgc>Tgc	p.R674C		NM_024312.4	NP_077288.2	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	674					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						TTCGGGAAGCGTTTTTCTTTG	0.418000													17	67					0	0	1	0	0
SCUBE3	222663	broad.mit.edu	37	6	35212573	35212573	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:35212573G>A	ENST00000274938.7	+	18	2386	c.2386G>A	c.(2386-2388)Gtg>Atg	p.V796M	SCUBE3_ENST00000394681.1_Missense_Mutation_p.V812M	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	796					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						CTCTACCAGTGTGGCCCAATG	0.557000													38	57					0	0	1	0	0
EMCN	51705	broad.mit.edu	37	4	101386659	101386659	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:101386659G>T	ENST00000296420.4	-	4	475	c.297C>A	c.(295-297)gaC>gaA	p.D99E	EMCN_ENST00000511970.1_Missense_Mutation_p.D99E|EMCN_ENST00000502327.1_5'UTR|EMCN_ENST00000305864.3_Missense_Mutation_p.D99E	NM_001159694.1|NM_016242.3	NP_001153166.1|NP_057326.2	Q9ULC0	MUCEN_HUMAN	endomucin	99	Thr-rich.					extracellular region|integral to membrane|plasma membrane				endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(123;2.49e-08)		AAATGATGGAGTCATTCTTCC	0.353000													24	28					4.72057e-08	4.96844e-08	1	1	0
PAN2	9924	broad.mit.edu	37	12	56716848	56716848	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56716848G>A	ENST00000425394.2	-	17	2879	c.2503C>T	c.(2503-2505)Cag>Tag	p.Q835*	PAN2_ENST00000548043.1_Nonsense_Mutation_p.Q835*|PAN2_ENST00000257931.5_Nonsense_Mutation_p.Q834*|PAN2_ENST00000440411.3_Nonsense_Mutation_p.Q831*	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	835					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TCAACAACCTGCATCTCATCC	0.483000													14	41					0	0	1	0	0
LMX1B	4010	broad.mit.edu	37	9	129455510	129455510	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:129455510C>T	ENST00000355497.5	+	4	656	c.649C>T	c.(649-651)Cgg>Tgg	p.R217W	LMX1B_ENST00000425646.2_Missense_Mutation_p.R194W|LMX1B_ENST00000526117.1_Missense_Mutation_p.R217W|LMX1B_ENST00000373474.4_Missense_Mutation_p.R217W|LMX1B_ENST00000561065.1_Missense_Mutation_p.R194W	NM_001174146.1	NP_001167617.1	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	194					dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	15						GAAGGACCCGCGGAGGCCCAA	0.652000									Nail-Patella Syndrome				4	4					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144895096	144895096	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144895096G>A	ENST00000356994.2	-	8	684	c.678C>T	c.(676-678)gaC>gaT	p.D226D	SCRIB_ENST00000377533.3_Silent_p.D145D|SCRIB_ENST00000320476.3_Silent_p.D226D	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	226	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TTTCCGACACGTCCAGGCACA	0.692000													5	10					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40711437	40711437	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:40711437C>A	ENST00000454349.2	+	20	5040	c.4829C>A	c.(4828-4830)cCa>cAa	p.P1610Q	TNRC6B_ENST00000402203.1_Missense_Mutation_p.P806Q|TNRC6B_ENST00000301923.9_Missense_Mutation_p.P806Q|TNRC6B_ENST00000335727.8_Missense_Mutation_p.P1500Q	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1610					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						AACCCCAAACCATCATCTCCC	0.582000													15	33					1.3612e-06	1.41782e-06	1	1	0
SUCLG1	8802	broad.mit.edu	37	2	84660507	84660507	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:84660507C>T	ENST00000393868.2	-	6	852	c.642G>A	c.(640-642)acG>acA	p.T214T		NM_003849.3	NP_003840.2	P53597	SUCA_HUMAN	succinate-CoA ligase, alpha subunit	214					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity			kidney(4)|large_intestine(4)|lung(2)	10					Succinic acid(DB00139)	ATCCAACTTGCGTTGTTTGGT	0.378000													11	12					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128971754	128971754	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:128971754G>T	ENST00000314797.6	+	5	383	c.279G>T	c.(277-279)aaG>aaT	p.K93N		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	93					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										TGACCATCAAGGAGATGTCTT	0.532000													38	47					1.30998e-17	1.4425e-17	1	1	0
ZNF184	7738	broad.mit.edu	37	6	27420267	27420267	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:27420267C>T	ENST00000211936.6	-	6	1355	c.1071G>A	c.(1069-1071)acG>acA	p.T357T	ZNF184_ENST00000377419.1_Silent_p.T357T	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	357					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T357T(1)		breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						GTTTTTCTCCCGTATGAATTT	0.378000													32	45					0	0	1	0	0
CCDC65	85478	broad.mit.edu	37	12	49314997	49314997	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49314997A>G	ENST00000266984.5	+	8	1453	c.1226A>G	c.(1225-1227)aAc>aGc	p.N409S	ARF3_ENST00000398092.4_Intron|CCDC65_ENST00000320516.4_Missense_Mutation_p.N409S			Q8IXS2	CCD65_HUMAN	coiled-coil domain containing 65	409										breast(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	15						AAAAGGTACAACAAAGTGAAA	0.498000													4	27					0	0	1	0	0
IL16	3603	broad.mit.edu	37	15	81552188	81552188	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:81552188G>A	ENST00000394660.2	+	3	748	c.388G>A	c.(388-390)Gcc>Acc	p.A130T	IL16_ENST00000302987.4_Missense_Mutation_p.A130T	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	130					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GTTTCCTAAAGCCTGCCACCA	0.468000													30	53					0	0	1	0	0
RAB40C	57799	broad.mit.edu	37	16	676092	676092	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:676092G>A	ENST00000535977.1	+	6	758	c.536G>A	c.(535-537)gGc>gAc	p.G179D	RAB40C_ENST00000248139.3_Missense_Mutation_p.G179D|RAB40C_ENST00000539661.1_Missense_Mutation_p.G179D|RAB40C_ENST00000538492.1_Missense_Mutation_p.G179D	NM_001172663.1	NP_001166134.1	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	179	SOCS box.				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			NS(1)|endometrium(2)|large_intestine(1)|lung(1)|prostate(1)	6		Hepatocellular(780;0.0218)				ATGCGGCACGGCATGGAGAAG	0.627000													19	22					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5568090	5568090	+	Silent	SNP	G	G	A	rs144865943	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:5568090G>A	ENST00000331789.5	-	4	815	c.624C>T	c.(622-624)atC>atT	p.I208I		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	208					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TGTCACGCACGATTTCCCGCT	0.612000													31	46					0	0	1	0	0
PCDHAC2	0	broad.mit.edu	37	5	140348837	140348837	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140348837G>T	ENST00000289269.5	+	1	3018	c.2486G>T	c.(2485-2487)aGc>aTc	p.S829I	PCDHA7_ENST00000525929.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		829					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGACTGACAGCAGGAATCTC	0.517000													8	14					0.000157383	0.000161063	1	1	0
LRRK2	120892	broad.mit.edu	37	12	40653310	40653310	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:40653310G>T	ENST00000298910.7	+	13	1505	c.1447G>T	c.(1447-1449)Gtg>Ttg	p.V483L	LRRK2_ENST00000343742.2_Missense_Mutation_p.V483L	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	483					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AATGGCAGCAGTGGTCCCCAA	0.393000													6	101					0.00198382	0.0020125	1	1	0
TBX4	9496	broad.mit.edu	37	17	59560514	59560514	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:59560514G>A	ENST00000393853.4	+	9	1441	c.1278G>A	c.(1276-1278)ccG>ccA	p.P426P	TBX4_ENST00000589449.1_3'UTR|TBX4_ENST00000240335.1_Silent_p.P425P			P57082	TBX4_HUMAN	T-box 4	425					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CAGTGTCGCCGTACACCAGCT	0.627000													19	31					0	0	1	0	0
ATP13A2	23400	broad.mit.edu	37	1	17322788	17322788	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:17322788G>A	ENST00000452699.1	-	14	1488	c.1299C>T	c.(1297-1299)ctC>ctT	p.L433L	ATP13A2_ENST00000502860.1_5'UTR|ATP13A2_ENST00000341676.5_Silent_p.L433L|RP1-37C10.3_ENST00000446261.1_RNA|ATP13A2_ENST00000326735.8_Silent_p.L438L	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	438					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		AGATGGTGCCGAGGAGAGCTG	0.662000													16	22					0	0	1	0	0
PLEKHA1	59338	broad.mit.edu	37	10	124157456	124157456	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:124157456G>A	ENST00000368988.1	+	3	287	c.164G>A	c.(163-165)cGt>cAt	p.R55H	PLEKHA1_ENST00000433307.1_Missense_Mutation_p.R55H|PLEKHA1_ENST00000538022.1_Missense_Mutation_p.R55H|PLEKHA1_ENST00000494222.1_3'UTR|PLEKHA1_ENST00000368989.2_Missense_Mutation_p.R55H|PLEKHA1_ENST00000368990.3_Missense_Mutation_p.R55H			Q9HB21	PKHA1_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	55	PH 1.				B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	13		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGATCATCACGTGTTGGAGCC	0.294000													6	60					0	0	1	0	0
CTSH	1512	broad.mit.edu	37	15	79229690	79229690	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:79229690C>T	ENST00000220166.5	-	3	308	c.199G>A	c.(199-201)Gcc>Acc	p.A67T		NM_004390.3	NP_004381.2	P09668	CATH_HUMAN	cathepsin H	67					protein destabilization|proteolysis	lysosome	cysteine-type endopeptidase activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)	10						TTGTTGTGGGCGTTTATCTTC	0.512000													33	50					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70265948	70265948	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:70265948A>G	ENST00000346329.3	+	9	973	c.665A>G	c.(664-666)cAc>cGc	p.H222R	CTTN_ENST00000301843.8_Missense_Mutation_p.H222R|CTTN_ENST00000376561.3_Missense_Mutation_p.H222R	NM_138565.2	NP_612632.1	Q14247	SRC8_HUMAN	cortactin	222						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		ACGGAGAAGCACGAGTCCCAG	0.478000													12	17					0	0	1	0	0
BCAR1	9564	broad.mit.edu	37	16	75263755	75263755	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:75263755G>A	ENST00000546196.1	-	7	3832	c.2180C>T	c.(2179-2181)aCc>aTc	p.T727I	BCAR1_ENST00000393420.6_Missense_Mutation_p.T774I|BCAR1_ENST00000542031.2_Missense_Mutation_p.T754I|BCAR1_ENST00000538440.2_Missense_Mutation_p.T756I|BCAR1_ENST00000420641.3_Missense_Mutation_p.T774I|BCAR1_ENST00000535626.2_Missense_Mutation_p.T608I|BCAR1_ENST00000393422.2_Missense_Mutation_p.T774I|BCAR1_ENST00000418647.3_Missense_Mutation_p.T802I|BCAR1_ENST00000566982.1_5'UTR|BCAR1_ENST00000162330.5_Missense_Mutation_p.T756I			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	756					actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGTCAGTGTGGTCAGGTTGGC	0.667000													28	34					0	0	1	0	0
HAS3	3038	broad.mit.edu	37	16	69148911	69148911	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:69148911C>A	ENST00000306560.1	+	4	1560	c.1404C>A	c.(1402-1404)acC>acA	p.T468T	HAS3_ENST00000569188.1_Silent_p.T468T|HAS3_ENST00000219322.3_Intron	NM_005329.2	NP_005320.2	O00219	HAS3_HUMAN	hyaluronan synthase 3	468					carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|urinary_tract(2)	16		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		GCTGGGGCACCTCTGGCCGAA	0.527000													11	75					1.08611e-07	1.14056e-07	1	1	0
FAM86DP	0	broad.mit.edu	37	3	75481979	75481979	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:75481979G>T	ENST00000459803.1	-	0	173					NR_024241.1																						ATATCCCGCAGCAGCTCAGAA	0.488000													27	50					1.26612e-14	1.38261e-14	1	1	0
F13A1	2162	broad.mit.edu	37	6	6197473	6197473	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:6197473G>A	ENST00000264870.3	-	9	1464	c.1199C>T	c.(1198-1200)cCc>cTc	p.P400L		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	400					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	ATTTTCCTGGGGGGTGCTGTC	0.473000													3	37					0	0	1	0	0
TFIP11	24144	broad.mit.edu	37	22	26890809	26890809	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:26890809C>T	ENST00000407690.1	-	13	2229	c.1946G>A	c.(1945-1947)aGc>aAc	p.S649N	TFIP11_ENST00000407148.1_Missense_Mutation_p.S649N|TFIP11_ENST00000407431.1_Missense_Mutation_p.S649N|TFIP11_ENST00000405938.1_Missense_Mutation_p.S649N	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	649					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						TCCCACCAGGCTAGAGACAGA	0.502000													13	30					0	0	1	0	0
SKOR1	390598	broad.mit.edu	37	15	68118589	68118589	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:68118589C>T	ENST00000380035.2	+	2	481	c.423C>T	c.(421-423)gcC>gcT	p.A141A	SKOR1_ENST00000341418.5_Silent_p.A327A|SKOR1_ENST00000554054.1_Silent_p.A113A|SKOR1_ENST00000554240.1_Silent_p.A102A|SKOR1_ENST00000389002.1_Silent_p.A132A			P84550	SKOR1_HUMAN	SKI family transcriptional corepressor 1	141					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity			endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(7)|urinary_tract(1)	23						TGCGTCGGGCCGGGGCCATGC	0.627000													13	17					0	0	1	0	0
SECISBP2	79048	broad.mit.edu	37	9	91940523	91940523	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:91940523T>G	ENST00000375807.3	+	3	435	c.364T>G	c.(364-366)Ttt>Gtt	p.F122V	SECISBP2_ENST00000534113.2_Missense_Mutation_p.F54V|SECISBP2_ENST00000339901.4_Missense_Mutation_p.F49V|SECISBP2_ENST00000470305.1_3'UTR	NM_024077.3	NP_076982.3	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	122					translation	nucleus	mRNA 3'-UTR binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(3)|skin(2)	32						TTACCGAGGTTTTCAAACAGT	0.423000													58	105					0	0	1	0	0
FARP2	9855	broad.mit.edu	37	2	242401943	242401943	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:242401943G>A	ENST00000264042.3	+	15	1763	c.1593G>A	c.(1591-1593)gtG>gtA	p.V531V	FARP2_ENST00000545004.1_Silent_p.V531V|FARP2_ENST00000373287.4_Silent_p.V531V	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	531					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		TTCAGCGCGTGCCTGCAGACG	0.498000													18	31					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158151319	158151319	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158151319G>A	ENST00000368171.3	+	3	635	c.136G>A	c.(136-138)Ggc>Agc	p.G46S		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	46					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					GCGCACCGACGGCTTGGCGTG	0.637000													46	103					0	0	1	0	0
NPTXR	23467	broad.mit.edu	37	22	39218726	39218726	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:39218726C>T	ENST00000333039.2	-	5	1514	c.1391G>A	c.(1390-1392)tGc>tAc	p.C464Y		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	464	Pentaxin.					integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					TGGCGCAGTGCAGTTGGCAAT	0.612000													6	17					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57719789	57719789	+	Silent	SNP	G	G	A	rs150564489		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57719789G>A	ENST00000333493.4	+	11	1652	c.1491G>A	c.(1489-1491)ccG>ccA	p.P497P	GPR97_ENST00000450388.3_Silent_p.P377P|GPR97_ENST00000327655.6_Silent_p.P287P|RP11-405F3.4_ENST00000563062.1_RNA	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	497					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.P497P(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TCTTCACCCCGTTGGGCCTCT	0.612000													22	41					0	0	1	0	0
POLG	5428	broad.mit.edu	37	15	89866119	89866119	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:89866119A>G	ENST00000268124.5	-	14	2613	c.2280T>C	c.(2278-2280)tgT>tgC	p.C760C	POLG_ENST00000442287.2_Silent_p.C760C	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	760					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			TTCCCACATTACAGCTATTAC	0.612000								DNA polymerases (catalytic subunits)					22	37					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67290915	67290915	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67290915G>A	ENST00000299798.11	+	7	1299	c.1234G>A	c.(1234-1236)Gcc>Acc	p.A412T		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	412					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		GGGGGCTGTGGCCTTTGCTCT	0.552000													45	75					0	0	1	0	0
LRIT3	345193	broad.mit.edu	37	4	110789072	110789072	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:110789072A>G	ENST00000327908.3	+	3	1080	c.316A>G	c.(316-318)Aga>Gga	p.R106G	LRIT3_ENST00000379920.3_Missense_Mutation_p.R244G|LRIT3_ENST00000409621.2_Missense_Mutation_p.R106G|LRIT3_ENST00000594814.1_Missense_Mutation_p.R289G			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	244						integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		CACATGGACCAGATCTGACAG	0.453000													25	40					0	0	1	0	0
NME1	4830	broad.mit.edu	37	17	49237346	49237346	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:49237346C>T	ENST00000511355.1	+	3	218	c.132C>T	c.(130-132)tcC>tcT	p.S44S	NME1_ENST00000013034.3_Silent_p.S69S|NME1_ENST00000480143.1_Silent_p.S69S|NME2_ENST00000393193.2_Silent_p.S44S|NME1_ENST00000393196.3_Silent_p.S44S|NME2_ENST00000376392.6_Silent_p.S44S|NME1_ENST00000336097.3_Silent_p.S69S|NME2_ENST00000555572.1_Silent_p.S69S					NME/NM23 nucleoside diphosphate kinase 1											endometrium(1)|large_intestine(1)|lung(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			AATAGGCTTCCGAAGATCTTC	0.463000													14	63					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	57003985	57003985	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57003985G>A	ENST00000179765.5	-	10	1903	c.1704C>T	c.(1702-1704)aaC>aaT	p.N568N	BAZ2A_ENST00000379441.3_Silent_p.N570N|BAZ2A_ENST00000551812.1_Silent_p.N600N|BAZ2A_ENST00000549884.1_Silent_p.N598N			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	600	MBD.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						TGTGTACCACGTTGCGGCTCA	0.493000													25	40					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131222276	131222276	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:131222276C>T	ENST00000337057.3	-	7	1155	c.974G>A	c.(973-975)cGc>cAc	p.R325H	EPB41L2_ENST00000530481.1_Missense_Mutation_p.R325H|EPB41L2_ENST00000368128.2_Missense_Mutation_p.R325H|EPB41L2_ENST00000525193.1_Missense_Mutation_p.R325H|EPB41L2_ENST00000527411.1_Missense_Mutation_p.R325H|EPB41L2_ENST00000528282.1_Missense_Mutation_p.R325H|EPB41L2_ENST00000392427.3_Missense_Mutation_p.R325H|EPB41L2_ENST00000529208.1_Missense_Mutation_p.R325H|EPB41L2_ENST00000527659.1_Missense_Mutation_p.R325H|EPB41L2_ENST00000525271.1_Missense_Mutation_p.R325H|EPB41L2_ENST00000530148.1_5'UTR|EPB41L2_ENST00000445890.2_Missense_Mutation_p.R325H	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	325	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		GCAGGGCAGGCGGCCAGAGGC	0.552000													19	31					0	0	1	0	0
SUCLA2	8803	broad.mit.edu	37	13	48523739	48523739	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:48523739C>T	ENST00000378654.3	-	9	1164		c.e9-1		SUCLA2_ENST00000543413.1_Splice_Site|SUCLA2_ENST00000544100.1_Splice_Site|SUCLA2_ENST00000534875.1_Splice_Site	NM_003850.2	NP_003841.1	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit						succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(4)	15		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	TAGCCAGTACCTATGAATAAA	0.313000													11	50					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34064260	34064260	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:34064260G>A	ENST00000389232.4	+	63	9026	c.8956G>A	c.(8956-8958)Gtt>Att	p.V2986I	RYR3_ENST00000415757.3_Missense_Mutation_p.V2986I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2986					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GATTAAAGGCGTTTCTCAGAA	0.448000													11	10					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41580698	41580698	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:41580698A>G	ENST00000396942.1	-	9	937	c.854T>C	c.(853-855)gTg>gCg	p.V285A	ANK1_ENST00000347528.4_Missense_Mutation_p.V285A|ANK1_ENST00000289734.7_Missense_Mutation_p.V285A|ANK1_ENST00000265709.8_Missense_Mutation_p.V318A|ANK1_ENST00000396945.1_Missense_Mutation_p.V285A|ANK1_ENST00000352337.4_Missense_Mutation_p.V285A|ANK1_ENST00000379758.2_Missense_Mutation_p.V285A			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	285	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGAGATTCGCACGTGCCCATT	0.507000													31	48					0	0	1	0	0
TRIM5	85363	broad.mit.edu	37	11	5686330	5686330	+	Silent	SNP	G	G	A	rs56397848		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5686330G>A	ENST00000305836.5	-	8	1493	c.1191C>T	c.(1189-1191)taC>taT	p.Y397Y	TRIM5_ENST00000380027.1_Intron|TRIM5_ENST00000380034.3_Silent_p.Y397Y|TRIM5_ENST00000483835.1_Intron|TRIM5_ENST00000396853.4_Intron|TRIM5_ENST00000396855.3_Intron|TRIM5_ENST00000396847.3_3'UTR			Q9C035	TRIM5_HUMAN	tripartite motif containing 5	397	B30.2/SPRY.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		CCCAGTAGCCGTATTTAGGTT	0.423000													52	83					0	0	1	0	0
PCDHGB1	0	broad.mit.edu	37	5	140731491	140731491	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140731491C>T	ENST00000523390.1	+	1	1664	c.1664C>T	c.(1663-1665)gCg>gTg	p.A555V	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1												p.A555V(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGACAATGCGCCACGGGTG	0.692000													24	30					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32372925	32372925	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32372925G>T	ENST00000454136.3	-	2	222	c.218C>A	c.(217-219)cCt>cAt	p.P73H	BTNL2_ENST00000429232.2_Missense_Mutation_p.P73H|BTNL2_ENST00000374993.1_Missense_Mutation_p.P73H|BTNL2_ENST00000374995.3_Missense_Mutation_p.P73H|BTNL2_ENST00000544175.1_Intron|BTNL2_ENST00000540315.1_Intron|BTNL2_ENST00000414363.1_Intron			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	73	Ig-like V-type 1.					integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						CACAAACACAGGTGTGCTGGG	0.562000													24	32					1.64293e-13	1.78609e-13	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11593032	11593032	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:11593032A>T	ENST00000262442.3	+	20	3961	c.3893A>T	c.(3892-3894)gAg>gTg	p.E1298V	DNAH9_ENST00000454412.2_Missense_Mutation_p.E1298V	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1298	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGCAGGAAGGAGGTCTGCCAG	0.532000													32	51					0	0	1	0	0
GABBR1	0	broad.mit.edu	37	6	29599295	29599295	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:29599295A>T	ENST00000377034.4	-	3	502	c.167T>A	c.(166-168)tTc>tAc	p.F56Y	GABBR1_ENST00000377016.4_Missense_Mutation_p.F56Y|GABBR1_ENST00000376977.3_Missense_Mutation_p.F56Y	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	56	Sushi 1.				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	CACTGGCAGGAAGTTGATAGC	0.627000													42	47					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20829186	20829186	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:20829186G>A	ENST00000601440.1	-	2	175	c.29C>T	c.(28-30)gCc>gTc	p.A10V	CTC-513N18.7_ENST00000595094.1_lincRNA|ZNF626_ENST00000291750.6_Missense_Mutation_p.A10V	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						GAATTCTATGGCCACATCTCT	0.413000													52	95					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112440445	112440445	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:112440445G>A	ENST00000230538.7	-	34	5132	c.4735C>T	c.(4735-4737)Ctt>Ttt	p.L1579F	LAMA4_ENST00000389463.4_Missense_Mutation_p.L1572F|LAMA4_ENST00000424408.2_Missense_Mutation_p.L1572F|LAMA4_ENST00000522006.1_Missense_Mutation_p.L1572F	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	1579	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GTAGGAGGAAGACTTTCTTCT	0.468000													39	46					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3085292	3085292	+	Silent	SNP	C	C	T	rs144260163	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:3085292C>T	ENST00000397461.1	+	22	3099	c.2715C>T	c.(2713-2715)ccC>ccT	p.P905P	CNTN4-AS1_ENST00000442749.2_RNA|CNTN4_ENST00000397459.2_Silent_p.P577P|CNTN4_ENST00000358480.3_Silent_p.P686P|CNTN4_ENST00000448906.2_Silent_p.P577P|CNTN4_ENST00000418658.1_Silent_p.P905P|CNTN4_ENST00000427331.1_Silent_p.P905P	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	905	Fibronectin type-III 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GTCAACCCCCCGGAAACATCA	0.373000													33	44					0	0	1	0	0
PAX9	5083	broad.mit.edu	37	14	37145538	37145538	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:37145538C>T	ENST00000361487.6	+	4	1132	c.907C>T	c.(907-909)Caa>Taa	p.Q303*	PAX9_ENST00000402703.2_Nonsense_Mutation_p.Q303*|PAX9_ENST00000554201.1_3'UTR|PAX9_ENST00000557107.1_3'UTR			P55771	PAX9_HUMAN	paired box 9	303					multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(3)	12	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		ACATGGGTGGCAACATGCTGG	0.557000													40	58					0	0	1	0	0
FKBP15	23307	broad.mit.edu	37	9	115935780	115935780	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:115935780C>T	ENST00000238256.3	-	23	2602	c.2485G>A	c.(2485-2487)Gca>Aca	p.A829T		NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	829					endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						TCTCTCTGTGCGCACACCTCC	0.488000													23	30					0	0	1	0	0
EZH1	2145	broad.mit.edu	37	17	40870502	40870502	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40870502G>A	ENST00000428826.2	-	9	1022	c.901C>T	c.(901-903)Cgc>Tgc	p.R301C	EZH1_ENST00000590078.1_Missense_Mutation_p.R231C|EZH1_ENST00000585893.1_Missense_Mutation_p.R261C|EZH1_ENST00000435174.1_Missense_Mutation_p.R162C|EZH1_ENST00000415827.2_Missense_Mutation_p.R292C|EZH1_ENST00000592743.1_Missense_Mutation_p.R301C			Q92800	EZH1_HUMAN	enhancer of zeste homolog 1 (Drosophila)	301					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			breast(1)|endometrium(4)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	27		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		TTAAAGCAGCGCCGGCAAAAA	0.532000													8	33					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248781	20248781	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:20248781G>A	ENST00000315957.4	+	1	381	c.300G>A	c.(298-300)caG>caA	p.Q100Q		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCATTGCACAGCTCTTCTTCT	0.468000													63	111					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168281192	168281192	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:168281192G>A	ENST00000366806.2	+	6	1034	c.892G>A	c.(892-894)Gcc>Acc	p.A298T	MLLT4_ENST00000344191.4_Missense_Mutation_p.A298T|MLLT4_ENST00000351017.4_Missense_Mutation_p.A298T|MLLT4_ENST00000392112.1_Missense_Mutation_p.A297T|MLLT4_ENST00000447894.2_Missense_Mutation_p.A298T|MLLT4_ENST00000392108.3_Missense_Mutation_p.A298T|MLLT4_ENST00000400822.3_Missense_Mutation_p.A297T			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	298	Ras-associating 2.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TTACTGCATCGCCCGGGTAAG	0.383000			T	MLL	AL								49	82					0	0	1	0	0
OSBPL2	9885	broad.mit.edu	37	20	60859167	60859167	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:60859167C>T	ENST00000313733.3	+	10	1140	c.938C>T	c.(937-939)tCg>tTg	p.S313L	OSBPL2_ENST00000439951.2_Missense_Mutation_p.S221L|OSBPL2_ENST00000358053.2_Missense_Mutation_p.S301L	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	313					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GATCCTGTTTCGTATGAATCC	0.483000													30	29					0	0	1	0	0
ARHGEF40	55701	broad.mit.edu	37	14	21541329	21541329	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:21541329C>T	ENST00000298694.4	+	2	256	c.129C>T	c.(127-129)gaC>gaT	p.D43D	ARHGEF40_ENST00000298693.3_Silent_p.D43D			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	43					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						ATCGGGAGGACGCACTGAGGT	0.607000													8	17					0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87447713	87447713	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:87447713G>A	ENST00000517970.1	+	15	1941	c.1634G>A	c.(1633-1635)cGc>cAc	p.R545H	WWP1_ENST00000265428.4_Missense_Mutation_p.R545H|WWP1_ENST00000341922.2_Missense_Mutation_p.R415H|WWP1_ENST00000349423.2_Missense_Mutation_p.R327H	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	545					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						GCTTATGAACGCGGCTTTAGG	0.299000													22	51					0	0	1	0	0
TMEM251	26175	broad.mit.edu	37	14	93653013	93653013	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:93653013G>A	ENST00000415050.2	+	2	882	c.507G>A	c.(505-507)acG>acA	p.T169T	RP11-371E8.4_ENST00000557048.1_Intron|RP11-371E8.4_ENST00000557574.1_Intron|TMEM251_ENST00000283534.4_Silent_p.T131T	NM_001098621.1	NP_001092091.1			transmembrane protein 251																		TGATTGACACGTAAAATCAGT	0.428000													48	69					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176310871	176310871	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176310871C>A	ENST00000292432.5	-	15	2045		c.e15-1			NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)						glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTCCACTGCCTGCACACAAA	0.582000													27	54					4.22769e-11	4.54161e-11	1	1	0
SH2B2	10603	broad.mit.edu	37	7	101960818	101960818	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:101960818C>T	ENST00000536178.1	+	9	1578	c.1533C>T	c.(1531-1533)aaC>aaT	p.N511N	SH2B2_ENST00000306803.8_Silent_p.N471N			O14492	SH2B2_HUMAN	SH2B adaptor protein 2	472	SH2.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	9						TGTCCCTGAACGGCCACGGCC	0.637000													22	38					0	0	1	0	0
TEFM	79736	broad.mit.edu	37	17	29231393	29231393	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:29231393G>A	ENST00000580840.1	-	2	222	c.186C>T	c.(184-186)gaC>gaT	p.D62D	TEFM_ENST00000581216.1_Silent_p.D62D			Q96QE5	TEFM_HUMAN	transcription elongation factor, mitochondrial	62					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding										AGAAGAGCTTGTCAAGTGCAT	0.398000													16	61					0	0	1	0	0
ARHGAP19-SLIT1	0	broad.mit.edu	37	10	99025877	99025877	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99025877G>A	ENST00000453547.2	-	2	61	c.62C>T	c.(61-63)gCc>gTc	p.A21V	ARHGAP19_ENST00000358531.4_Missense_Mutation_p.A21V|ARHGAP19-SLIT1_ENST00000316676.8_Missense_Mutation_p.A21V|ARHGAP19_ENST00000355366.5_Missense_Mutation_p.A12V|ARHGAP19-SLIT1_ENST00000358308.3_Missense_Mutation_p.A21V|ARHGAP19_ENST00000371027.1_Missense_Mutation_p.A12V																							ACTGCAGATGGCATCACTGAA	0.408000													30	42					0	0	1	0	0
RANBP3	8498	broad.mit.edu	37	19	5933453	5933453	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5933453C>T	ENST00000340578.6	-	6	501	c.444G>A	c.(442-444)acG>acA	p.T148T	RANBP3_ENST00000591092.1_Silent_p.T80T|RANBP3_ENST00000541471.1_Silent_p.T20T|RANBP3_ENST00000034275.8_Silent_p.T80T|RANBP3_ENST00000439268.2_Silent_p.T148T|RANBP3_ENST00000591124.1_5'UTR	NM_003624.2|NM_007320.2|NM_007322.2	NP_003615.2|NP_015559.2|NP_015561.1	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3	148					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	18						CGTGGATCAGCGTTGGTGGCT	0.622000													9	24					0	0	1	0	0
ZNF793	390927	broad.mit.edu	37	19	38028242	38028242	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38028242G>A	ENST00000445217.1	+	4	717	c.682G>A	c.(682-684)Gtc>Atc	p.V228I	ZNF793_ENST00000587143.1_Missense_Mutation_p.V228I|ZNF793_ENST00000589319.1_Intron|ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000542455.1_Missense_Mutation_p.V228I			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	228					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAAACCCCACGTCTGTAGTGA	0.478000													11	12					0	0	1	0	0
PLK4	0	broad.mit.edu	37	4	128812837	128812837	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:128812837G>A	ENST00000270861.5	+	9	2312		c.e9+1		PLK4_ENST00000507249.1_Splice_Site|PLK4_ENST00000515069.1_Splice_Site|PLK4_ENST00000513090.1_Splice_Site|PLK4_ENST00000514379.1_Splice_Site	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4						G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						AATTTACCAGGTATGTGAATT	0.313000													40	72					0	0	1	0	0
ITGA10	8515	broad.mit.edu	37	1	145533448	145533448	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145533448G>A	ENST00000369304.3	+	12	1506	c.1331G>A	c.(1330-1332)cGc>cAc	p.R444H	ITGA10_ENST00000538811.1_Missense_Mutation_p.R313H|ITGA10_ENST00000539363.1_Missense_Mutation_p.R301H	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	444					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGGGGTGGACGCCGCCTGTTT	0.527000													30	52					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91670089	91670089	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:91670089C>T	ENST00000359028.2	+	19	5055	c.4830C>T	c.(4828-4830)taC>taT	p.Y1610Y	AKAP9_ENST00000358100.2_Silent_p.Y1610Y|AKAP9_ENST00000356239.3_Silent_p.Y1598Y			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1610					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TACGACAATACCAAGAACATC	0.413000			T	BRAF	papillary thyroid								9	25					0	0	1	0	0
NPTXR	23467	broad.mit.edu	37	22	39218732	39218732	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:39218732G>A	ENST00000333039.2	-	5	1508	c.1385C>T	c.(1384-1386)gCc>gTc	p.A462V		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	462	Pentaxin.					integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					AGTGCAGTTGGCAATGCCCAG	0.607000													5	14					0	0	1	0	0
FOXR1	283150	broad.mit.edu	37	11	118849494	118849494	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118849494G>A	ENST00000317011.3	+	2	289	c.64G>A	c.(64-66)Gcc>Acc	p.A22T		NM_181721.2	NP_859072.1	Q6PIV2	FOXR1_HUMAN	forkhead box R1	22					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		TTTGCCAGTTGCCAGGTATAA	0.438000													29	37					0	0	1	0	0
DNA2	1763	broad.mit.edu	37	10	70229775	70229775	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:70229775G>C	ENST00000399180.2	-	2	477	c.478C>G	c.(478-480)Cta>Gta	p.L160V	DNA2_ENST00000399179.2_Missense_Mutation_p.L74V|DNA2_ENST00000358410.3_Missense_Mutation_p.L74V			P51530	DNA2L_HUMAN	DNA replication helicase/nuclease 2	74					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)	20						TTATTTTCTAGTGACTGTGAA	0.413000													21	35					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14787086	14787086	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:14787086C>T	ENST00000358984.4	+	15	1901	c.1721C>T	c.(1720-1722)tCt>tTt	p.S574F	ANKRD30B_ENST00000447268.2_Missense_Mutation_p.S574F|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	574										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						GAAGAAAATTCTTGGGATTCT	0.303000													9	42					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105201637	105201637	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:105201637G>A	ENST00000369797.3	+	31	4706	c.4612G>A	c.(4612-4614)Gct>Act	p.A1538T		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	1538					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTCAGGCTTCGCTTGGAATGT	0.597000													6	24					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31386391	31386391	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31386391G>A	ENST00000328111.2	+	15	1937	c.1616G>A	c.(1615-1617)cGg>cAg	p.R539Q	DNMT3B_ENST00000375623.4_3'UTR|DNMT3B_ENST00000344505.4_Missense_Mutation_p.R519Q|DNMT3B_ENST00000443239.3_Missense_Mutation_p.R477Q|DNMT3B_ENST00000456297.2_Missense_Mutation_p.R443Q|DNMT3B_ENST00000353855.2_Missense_Mutation_p.R519Q|DNMT3B_ENST00000201963.3_Missense_Mutation_p.R531Q|DNMT3B_ENST00000348286.2_Missense_Mutation_p.R519Q	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	539	ADD.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CTGCGGCGCCGGAAGGACTGG	0.642000													6	23					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2329104	2329104	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2329104G>A	ENST00000301732.5	-	29	5087	c.4387C>T	c.(4387-4389)Cag>Tag	p.Q1463*	ABCA3_ENST00000382381.3_Nonsense_Mutation_p.Q1405*	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	1463	ABC transporter 2.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				GCATCAAACTGCGGGCAGTAG	0.677000													17	30					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936658	15936658	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:15936658C>T	ENST00000504595.1	+	4	1320	c.839C>T	c.(838-840)aCg>aTg	p.T280M	FBXL7_ENST00000329673.7_Missense_Mutation_p.T268M|FBXL7_ENST00000510662.1_Missense_Mutation_p.T233M	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	280					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						CTGGACATGACGGACTGCTTC	0.612000													21	12					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118228729	118228729	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118228729C>T	ENST00000369230.3	+	9	1106	c.960C>T	c.(958-960)tgC>tgT	p.C320C		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	320					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		AAGAAGGTTGCCCAACAATGG	0.353000													8	55					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169229212	169229212	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:169229212C>T	ENST00000393743.3	-	4	500	c.209G>A	c.(208-210)cGc>cAc	p.R70H		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	70							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CACAAGATAGCGTTCAACCAG	0.338000													38	62					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41063166	41063166	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41063166G>A	ENST00000352632.3	+	26	5613	c.5527G>A	c.(5527-5529)Gcc>Acc	p.A1843T	SPTBN4_ENST00000595535.1_Missense_Mutation_p.A1843T|SPTBN4_ENST00000392023.1_Missense_Mutation_p.A519T|SPTBN4_ENST00000338932.3_Missense_Mutation_p.A1843T|SPTBN4_ENST00000392025.1_Missense_Mutation_p.A586T|SPTBN4_ENST00000598249.1_Missense_Mutation_p.A1843T			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1843					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton	p.A519S(1)|p.A1843S(1)		breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTTCAGTGACGCCCGAGAGCT	0.662000													14	25					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160277143	160277143	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:160277143G>A	ENST00000264431.4	+	23	4726	c.4307G>A	c.(4306-4308)cGg>cAg	p.R1436Q		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1436					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		CAGAGATCGCGGATGGTCGCA	0.587000													5	8					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248262906	248262906	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:248262906G>A	ENST00000366478.2	+	3	566	c.229G>A	c.(229-231)Gtc>Atc	p.V77I	OR2L13_ENST00000358120.2_Missense_Mutation_p.V77I	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding	p.V77I(2)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CTCCACCACCGTCCCCAAGAT	0.532000													36	65					0	0	1	0	0
SNRNP40	9410	broad.mit.edu	37	1	31734425	31734425	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:31734425G>A	ENST00000263694.4	-	9	993	c.975C>T	c.(973-975)ggC>ggT	p.G325G	SNRNP40_ENST00000373720.3_Silent_p.G95G|SNRNP40_ENST00000489853.1_5'UTR|SNRNP40_ENST00000446633.2_Silent_p.G325G	NM_004814.2	NP_004805.2	Q96DI7	SNR40_HUMAN	small nuclear ribonucleoprotein 40kDa (U5)	325						catalytic step 2 spliceosome|cytoplasm|nucleoplasm|small nucleolar ribonucleoprotein complex|U5 snRNP	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	7						AGCCAGCATGGCCGGGCAGCT	0.498000													4	44					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162451	96162451	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:96162451C>T	ENST00000225235.4	+	1	191	c.81C>T	c.(79-81)ggC>ggT	p.G27G		NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12	27						intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				ACCCCGTGGGCCAGGACAGGA	0.721000													11	6					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475801	120475801	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:120475801C>T	ENST00000355622.6	+	3	1496	c.1395C>T	c.(1393-1395)ggC>ggT	p.G465G	TLR4_ENST00000394487.4_Silent_p.G425G|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	465					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						CTTTCAATGGCATCTTCAATG	0.398000													29	72					0	0	1	0	0
CELF2	10659	broad.mit.edu	37	10	11207596	11207596	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:11207596C>T	ENST00000379261.4	+	2	293	c.201C>T	c.(199-201)taC>taT	p.Y67Y	CELF2_ENST00000416382.2_Silent_p.Y67Y|CELF2_ENST00000354897.3_Silent_p.Y43Y|CELF2_ENST00000450189.1_Silent_p.Y74Y|CELF2_ENST00000315874.3_Silent_p.Y43Y|CELF2_ENST00000399850.3_Silent_p.Y43Y|CELF2_ENST00000542579.1_Silent_p.Y74Y|CELF2_ENST00000537122.1_5'UTR|CELF2_ENST00000354440.2_Silent_p.Y43Y|CELF2_ENST00000427450.1_Silent_p.Y43Y|CELF2_ENST00000417956.2_Silent_p.Y43Y	NM_001025077.2	NP_001020248.1	O95319	CELF2_HUMAN	CUGBP, Elav-like family member 2	67	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.|RRM 1.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	16						GAGCCGTCTACCAGATCAACG	0.602000													7	12					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112711577	112711577	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112711577G>A	ENST00000550722.1	-	11	1787	c.1392C>T	c.(1390-1392)aaC>aaT	p.N464N	HECTD4_ENST00000377560.5_Silent_p.N426N|HECTD4_ENST00000430131.2_Silent_p.N176N	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		ATAGCATGTTGTTCACTGTGT	0.443000													26	37					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105001555	105001555	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:105001555C>T	ENST00000507740.1	+	14	2562	c.2326C>T	c.(2326-2328)Cga>Tga	p.R776*	RIMS2_ENST00000262231.10_Nonsense_Mutation_p.R823*|RIMS2_ENST00000436393.2_Nonsense_Mutation_p.R762*|RIMS2_ENST00000406091.3_Nonsense_Mutation_p.R984*	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1046					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.R762*(1)|p.R776*(1)|p.R1051*(1)		NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACAGGGGCTTCGAGGGACCCG	0.393000										HNSCC(12;0.0054)			43	51					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11361693	11361693	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11361693C>T	ENST00000294618.7	-	6	588	c.577G>A	c.(577-579)Gac>Aac	p.D193N		NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	193					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						TTCCTCAGGTCGAAGATGCTA	0.617000													6	25					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139818200	139818200	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:139818200C>T	ENST00000297183.6	+	3	739	c.615C>T	c.(613-615)gaC>gaT	p.D205D	ANKHD1_ENST00000394723.3_Silent_p.D205D|ANKHD1_ENST00000360839.2_Silent_p.D205D|ANKHD1_ENST00000394722.3_Silent_p.D194D|ANKHD1-EIF4EBP3_ENST00000532219.1_Silent_p.D205D	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAAGTGGACACGTATGTGT	0.408000													33	47					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36846737	36846737	+	Missense_Mutation	SNP	C	C	T	rs139310550		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:36846737C>T	ENST00000279024.4	-	12	2859	c.2588G>A	c.(2587-2589)cGg>cAg	p.R863Q		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	863										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				TTGCAGGCACCGCCTTCCTTC	0.582000													4	24					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4451488	4451488	+	Silent	SNP	G	G	A	rs141617248		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4451488G>A	ENST00000254718.4	-	12	1980	c.1674C>T	c.(1672-1674)aaC>aaT	p.N558N	MYBBP1A_ENST00000381556.2_Silent_p.N558N			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	558	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						CGGTGGTCACGTTGTGGCTGT	0.652000													20	24					0	0	1	0	0
FEM1B	10116	broad.mit.edu	37	15	68583314	68583314	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:68583314G>A	ENST00000306917.4	+	2	2233	c.1618G>A	c.(1618-1620)Gtt>Att	p.V540I		NM_015322.3	NP_056137.1	Q9UK73	FEM1B_HUMAN	fem-1 homolog b (C. elegans)	540					apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	9						TCATATTATCGTTCAGTACAA	0.473000													44	53					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50740993	50740993	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:50740993G>A	ENST00000355832.5	-	2	96	c.18C>T	c.(16-18)atC>atT	p.I6I	ERCC6-PGBD3_ENST00000515869.1_Silent_p.I6I|PGBD3_ENST00000603152.1_Silent_p.I6I|ERCC6-PGBD3_ENST00000447839.2_Silent_p.I6I	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	6					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TTGAGTGGGGGATTCCCTCAT	0.363000								Direct reversal of damage;Nucleotide excision repair (NER)					20	36					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67802360	67802360	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:67802360C>T	ENST00000544246.1	-	2	904	c.213G>A	c.(211-213)ggG>ggA	p.G71G	PCDH9_ENST00000377861.3_Silent_p.G71G|PCDH9_ENST00000328454.5_Silent_p.G71G|PCDH9_ENST00000456367.1_Silent_p.G71G|PCDH9_ENST00000377865.2_Silent_p.G71G	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	71	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.G71G(1)		breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		AAGGGGCATCCCCAGCTTTAG	0.488000													17	7					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27447233	27447233	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27447233C>T	ENST00000264705.4	+	9	1291	c.1129C>T	c.(1129-1131)Cgc>Tgc	p.R377C	CAD_ENST00000403525.1_Missense_Mutation_p.R377C	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	377	Linker.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCTGACTGAGCGCCTCTGTCC	0.577000													8	33					0	0	1	0	0
GAPVD1	26130	broad.mit.edu	37	9	128092363	128092363	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:128092363C>T	ENST00000470056.1	+	11	2199	c.2039C>T	c.(2038-2040)gCa>gTa	p.A680V	GAPVD1_ENST00000312123.9_Missense_Mutation_p.A659V|GAPVD1_ENST00000297933.6_Missense_Mutation_p.A680V|GAPVD1_ENST00000394104.2_Missense_Mutation_p.A680V|GAPVD1_ENST00000495955.1_Missense_Mutation_p.A680V|GAPVD1_ENST00000265956.4_Missense_Mutation_p.A680V|GAPVD1_ENST00000394105.2_Missense_Mutation_p.A680V|GAPVD1_ENST00000394083.2_Missense_Mutation_p.A659V			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	680					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						ACAGGTGCTGCAGCAGAGAAC	0.473000													5	107					0	0	1	0	0
GTDC1	79712	broad.mit.edu	37	2	144765062	144765062	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:144765062G>T	ENST00000409214.1	-	7	840	c.562C>A	c.(562-564)Ctc>Atc	p.L188I	GTDC1_ENST00000542155.1_Missense_Mutation_p.L188I|GTDC1_ENST00000392867.3_Missense_Mutation_p.L188I|GTDC1_ENST00000463875.2_Missense_Mutation_p.L59I|GTDC1_ENST00000241391.5_Missense_Mutation_p.L188I|GTDC1_ENST00000409298.1_Intron|GTDC1_ENST00000392869.1_Missense_Mutation_p.L188I|GTDC1_ENST00000344850.4_Missense_Mutation_p.L188I	NM_001006636.3	NP_001006637.1	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	188					biosynthetic process		transferase activity, transferring glycosyl groups			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(17)|ovary(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.0914)		TTAAGGCCGAGCATCTTCTTT	0.373000													20	27					9.57634e-11	1.02616e-10	1	1	0
C3	718	broad.mit.edu	37	19	6693082	6693082	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6693082G>A	ENST00000245907.6	-	26	3335	c.3243C>T	c.(3241-3243)taC>taT	p.Y1081Y		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1081					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CCTTGACCACGTAGGCGGTCA	0.592000													4	79					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62195572	62195572	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:62195572G>T	ENST00000467148.1	-	8	4672	c.4603C>A	c.(4603-4605)Ctc>Atc	p.L1535I	HELZ2_ENST00000427522.2_Missense_Mutation_p.L966I	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		TCAGCCACGAGCCTATTAAAC	0.642000													6	13					3.59834e-05	3.7043e-05	1	1	0
FMNL2	114793	broad.mit.edu	37	2	153475606	153475606	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:153475606G>A	ENST00000288670.9	+	14	1928	c.1561G>A	c.(1561-1563)Gct>Act	p.A521T		NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	521					actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						AATGGGGGCCGCTTCCTCAGG	0.572000													18	14					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123782717	123782717	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:123782717G>A	ENST00000420886.2	-	30	3846	c.3845_splice	c.e30-1	p.R1283_splice	SBNO1_ENST00000267176.4_Splice_Site_p.R1282_splice|SBNO1_ENST00000602398.1_Splice_Site_p.R1283_splice|SBNO1_ENST00000602750.1_Splice_Site_p.R1282_splice	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1283							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CAATTGCCGCGCCTAAGAAAA	0.378000													11	40					0	0	1	0	0
SLC28A3	64078	broad.mit.edu	37	9	86900404	86900404	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:86900404C>T	ENST00000376238.4	-	14	1552	c.1503G>A	c.(1501-1503)tgG>tgA	p.W501*	SLC28A3_ENST00000537648.1_Nonsense_Mutation_p.W432*|RP11-380F14.2_ENST00000419815.1_RNA	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	501					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						AGCTGTCCTGCCATTCCACTC	0.408000													39	51					0	0	1	0	0
WT1	7490	broad.mit.edu	37	11	32410718	32410718	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:32410718C>A	ENST00000332351.3	-	10	1724	c.1440G>T	c.(1438-1440)aaG>aaT	p.K480N	WT1_ENST00000448076.3_Missense_Mutation_p.K477N|WT1_ENST00000379079.2_Missense_Mutation_p.K265N|WT1_ENST00000530998.1_Missense_Mutation_p.K251N	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1	412					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			AGCTGAAGGGCTTTTCACCTG	0.483000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				22	40					2.79863e-10	2.98826e-10	1	1	0
TMEM147	10430	broad.mit.edu	37	19	36038088	36038088	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36038088G>A	ENST00000392204.2	+	5	678	c.350G>A	c.(349-351)cGg>cAg	p.R117Q	TMEM147_ENST00000392205.1_Missense_Mutation_p.R166Q|TMEM147_ENST00000222284.5_Missense_Mutation_p.R166Q	NM_001242597.1	NP_001229526.1	Q9BVK8	TM147_HUMAN	transmembrane protein 147	166						endoplasmic reticulum membrane|integral to membrane	protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	6	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CACACCTTCCGGCCAGCTGTC	0.552000													19	34					0	0	1	0	0
RAD17	5884	broad.mit.edu	37	5	68692341	68692341	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:68692341C>T	ENST00000509734.1	+	15	2251	c.1573C>T	c.(1573-1575)Cac>Tac	p.H525Y	RAD17_ENST00000305138.4_Missense_Mutation_p.H514Y|RAD17_ENST00000504177.1_Intron|RAD17_ENST00000354868.5_Missense_Mutation_p.H514Y|RAD17_ENST00000380774.3_Missense_Mutation_p.H525Y|RAD17_ENST00000521422.1_Missense_Mutation_p.H349Y|RAD17_ENST00000282891.6_Missense_Mutation_p.H428Y|RAD17_ENST00000354312.3_Missense_Mutation_p.H514Y|RAD17_ENST00000345306.6_Missense_Mutation_p.H514Y|RAD17_ENST00000358030.2_Missense_Mutation_p.H349Y|RAD17_ENST00000361732.2_Missense_Mutation_p.H514Y			O75943	RAD17_HUMAN	RAD17 homolog (S. pombe)	525	Interaction with MCM7.				cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding						Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		TCGACCCTTGCACAAACCTCA	0.358000								Other conserved DNA damage response genes					11	23					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183676028	183676028	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:183676028C>A	ENST00000511685.1	+	22	4631	c.4508C>A	c.(4507-4509)cCt>cAt	p.P1503H	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.P1503H					teneurin transmembrane protein 3																		AAGAATAAGCCTTTACTTAAC	0.423000													31	32					1.99505e-19	2.20731e-19	1	1	0
PRDM9	56979	broad.mit.edu	37	5	23522811	23522811	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:23522811G>A	ENST00000296682.3	+	8	881	c.699G>A	c.(697-699)ggG>ggA	p.G233G		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	233					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						TGGACAAGGGGCACCCCAACC	0.557000										HNSCC(3;0.000094)			11	19					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10976794	10976794	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:10976794G>A	ENST00000254488.2	+	13	1721	c.1655G>A	c.(1654-1656)gGc>gAc	p.G552D		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	552					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TGGGGCTATGGCATTGGCTGG	0.567000													45	70					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156918209	156918209	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156918209G>A	ENST00000368194.3	-	23	3046	c.2007C>T	c.(2005-2007)aaC>aaT	p.N669N	ARHGEF11_ENST00000361409.2_Silent_p.N629N|ARHGEF11_ENST00000315174.8_Silent_p.N45N	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	629					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGCGGGGCACGTTCTCTGCCT	0.602000													24	24					0	0	1	0	0
PGBD5	79605	broad.mit.edu	37	1	230461129	230461129	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:230461129G>A	ENST00000321327.2	-	8	1395	c.1396C>T	c.(1396-1398)Cca>Tca	p.P466S	PGBD5_ENST00000525115.1_Missense_Mutation_p.P367S|PGBD5_ENST00000530424.1_5'UTR|PGBD5_ENST00000391860.1_Missense_Mutation_p.P321S			Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	367						integral to membrane				biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(2)|skin(1)	33	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		AAGGGGCATGGGATCTCCCCA	0.527000													35	55					0	0	1	0	0
EIF2A	83939	broad.mit.edu	37	3	150289880	150289880	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:150289880C>T	ENST00000460851.1	+	10	1056	c.947C>T	c.(946-948)cCt>cTt	p.P316L	SERP1_ENST00000479209.1_Intron|EIF2A_ENST00000406576.3_Missense_Mutation_p.P255L|EIF2A_ENST00000273435.5_Missense_Mutation_p.P311L|EIF2A_ENST00000383043.3_Missense_Mutation_p.P102L|SERP1_ENST00000490945.1_Intron|EIF2A_ENST00000487799.1_Missense_Mutation_p.P291L			Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A, 65kDa	316					regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding			cervix(1)|endometrium(2)|kidney(1)|lung(3)	7		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GGAACTGGTCCTCGTAATGCA	0.398000													14	18					0	0	1	0	0
ESCO2	157570	broad.mit.edu	37	8	27633930	27633930	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:27633930T>C	ENST00000305188.8	+	3	343	c.105T>C	c.(103-105)tgT>tgC	p.C35C	ESCO2_ENST00000397418.2_5'UTR	NM_001017420.2	NP_001017420.1	Q56NI9	ESCO2_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 2	35					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		AAAAGCACTGTTTTTATCAAA	0.308000									SC Phocomelia syndrome				18	26					0	0	1	0	0
ARHGAP12	94134	broad.mit.edu	37	10	32096640	32096640	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:32096640C>A	ENST00000375250.5	-	18	2638	c.2397G>T	c.(2395-2397)caG>caT	p.Q799H	ARHGAP12_ENST00000396144.4_Missense_Mutation_p.Q824H|ARHGAP12_ENST00000311380.4_Missense_Mutation_p.Q777H|ARHGAP12_ENST00000344936.2_Missense_Mutation_p.Q829H|ARHGAP12_ENST00000492028.1_5'UTR|ARHGAP12_ENST00000375245.4_Missense_Mutation_p.Q777H	NM_001270696.1	NP_001257625.1	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	829	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(11)|lung(10)|skin(1)|urinary_tract(2)	31		Prostate(175;0.0199)				CAATCTGATTCTGGTACACAG	0.373000													18	17					1.99824e-07	2.09433e-07	1	1	0
BBS2	583	broad.mit.edu	37	16	56536302	56536302	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:56536302T>A	ENST00000245157.5	-	9	1427	c.1007A>T	c.(1006-1008)gAc>gTc	p.D336V	BBS2_ENST00000568104.1_Missense_Mutation_p.D336V|BBS2_ENST00000561951.1_5'UTR	NM_031885.3	NP_114091.3	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2	336					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)	26						TCGGATCAGGTCCTGCTCTGC	0.527000									Bardet-Biedl syndrome				38	46					0	0	1	0	0
RPUSD1	113000	broad.mit.edu	37	16	836249	836249	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:836249G>A	ENST00000561734.1	-	5	883	c.640C>T	c.(640-642)Cgc>Tgc	p.R214C	RPUSD1_ENST00000567114.1_Missense_Mutation_p.R85C|RPUSD1_ENST00000565809.1_3'UTR|RPUSD1_ENST00000007264.2_Missense_Mutation_p.R214C			Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing 1	214					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			endometrium(3)|lung(2)|skin(2)	7		Hepatocellular(780;0.00335)				GTGGGGATGCGCAGGTAGAAA	0.667000													5	76					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119962120	119962120	+	Silent	SNP	C	C	T	rs150892928	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:119962120C>T	ENST00000543831.1	+	3	471	c.222C>T	c.(220-222)gaC>gaT	p.D74D	HSD3B2_ENST00000471656.1_3'UTR|HSD3B2_ENST00000369416.3_Silent_p.D74D	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	74			D -> N (in dbSNP:rs4986954).		androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CCTGCCAGGACGTCTCGGTCG	0.502000													15	20					0	0	1	0	0
MAP3K1	4214	broad.mit.edu	37	5	56183331	56183331	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:56183331C>T	ENST00000399503.3	+	18	4241	c.4241C>T	c.(4240-4242)gCa>gTa	p.A1414V		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	1414	Protein kinase.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GGGACAATTGCATTTATGGCA	0.418000													17	128					0	0	1	0	0
PAMR1	25891	broad.mit.edu	37	11	35463154	35463154	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:35463154C>T	ENST00000378880.2	-	7	1353	c.908G>A	c.(907-909)cGc>cAc	p.R303H	PAMR1_ENST00000378878.3_Missense_Mutation_p.R192H|PAMR1_ENST00000278360.3_Missense_Mutation_p.R320H|PAMR1_ENST00000532848.1_Missense_Mutation_p.R263H	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	303	Sushi 1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						TTTAGCATGGCGTCCGTTGAT	0.468000													44	88					0	0	1	0	0
SOS2	6655	broad.mit.edu	37	14	50585340	50585340	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:50585340G>A	ENST00000216373.5	-	23	3995	c.3721C>T	c.(3721-3723)Cat>Tat	p.H1241Y	SOS2_ENST00000543680.1_Missense_Mutation_p.H1208Y	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	1241					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					CTGTGAAGATGCCCCAGTGGA	0.517000													29	35					0	0	1	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21946890	21946890	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:21946890G>A	ENST00000319481.3	-	4	454	c.248C>T	c.(247-249)aCg>aTg	p.T83M	OSBPL1A_ENST00000399441.4_Missense_Mutation_p.T83M|RP11-621L6.2_ENST00000579347.1_RNA|OSBPL1A_ENST00000582618.1_5'UTR	NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	83					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					ATGAAGCGGCGTGTCTCCCAT	0.393000													32	43					0	0	1	0	0
C19orf35	374872	broad.mit.edu	37	19	2278607	2278607	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2278607G>A	ENST00000342063.3	-	3	681	c.588C>T	c.(586-588)gaC>gaT	p.D196D		NM_198532.2	NP_940934.1	Q6ZS72	CS035_HUMAN	chromosome 19 open reading frame 35	196										large_intestine(1)|lung(5)|pancreas(1)|prostate(1)	8				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCCAGGCGTCCTCGTGCG	0.657000													9	8					0	0	1	0	0
C1QTNF9B	387911	broad.mit.edu	37	13	24465850	24465850	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:24465850C>T	ENST00000382137.3	-	3	648	c.580G>A	c.(580-582)Ggt>Agt	p.G194S	C1QTNF9B_ENST00000382145.1_Intron|C1QTNF9B-AS1_ENST00000382133.4_RNA|C1QTNF9B-AS1_ENST00000435039.2_RNA|C1QTNF9B_ENST00000556521.1_Intron|C1QTNF9B_ENST00000382057.3_Intron|C1QTNF9B_ENST00000382140.2_Missense_Mutation_p.G194S|C1QTNF9B-AS1_ENST00000417034.1_RNA	NM_001007537.1	NP_001007538.1	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	194						collagen				breast(1)|central_nervous_system(1)|large_intestine(3)|lung(1)	6						AGAGTCTCACCGATTTTCCCT	0.527000													4	44					0	0	1	0	0
PARP6	56965	broad.mit.edu	37	15	72533877	72533877	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:72533877G>A	ENST00000569795.1	-	24	2499	c.1812C>T	c.(1810-1812)ggC>ggT	p.G604G	PARP6_ENST00000413097.2_5'UTR|PARP6_ENST00000287196.9_Silent_p.G604G|PARP6_ENST00000260376.7_3'UTR			Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	604	PARP catalytic.						NAD+ ADP-ribosyltransferase activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	18						TGTTGGCATCGCCCACCTGAC	0.468000													18	31					0	0	1	0	0
JOSD1	9929	broad.mit.edu	37	22	39085305	39085305	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:39085305G>A	ENST00000216039.5	-	2	989	c.310C>T	c.(310-312)Cgc>Tgc	p.R104C		NM_014876.5	NP_055691.1	Q15040	JOS1_HUMAN	Josephin domain containing 1	104	Josephin.						peptidase activity			large_intestine(1)|lung(1)|ovary(2)|pancreas(1)	5	Melanoma(58;0.04)					GATTACCTGCGCTTGTCCCAC	0.483000													8	49					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943091	72943091	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72943091G>A	ENST00000328801.4	+	6	1141	c.1141G>A	c.(1141-1143)Gct>Act	p.A381T		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	381						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CTTCTATGTGGCTGTGCTGCC	0.602000													24	30					0	0	1	0	0
OPN3	23596	broad.mit.edu	37	1	241767567	241767567	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:241767567G>A	ENST00000366554.2	-	2	794	c.688C>T	c.(688-690)Cga>Tga	p.R230*	OPN3_ENST00000469376.1_Intron|OPN3_ENST00000331838.5_Intron	NM_014322.2	NP_055137.2	Q9H1Y3	OPN3_HUMAN	opsin 3	230					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|visual perception	integral to plasma membrane	G-protein coupled photoreceptor activity			endometrium(1)|large_intestine(5)|lung(5)	11	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CTCACCATTCGAATGGAATAT	0.448000													13	21					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10445344	10445344	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:10445344C>T	ENST00000326756.3	-	3	3047	c.2609G>A	c.(2608-2610)aGc>aAc	p.S870N		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						TAATTCACTGCTTCCTTGCTG	0.398000													21	26					0	0	1	0	0
C12orf63	0	broad.mit.edu	37	12	97158977	97158977	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:97158977G>A	ENST00000524981.3	+	27	3615	c.3615G>A	c.(3613-3615)tcG>tcA	p.S1205S				Q6ZTY8	CL063_HUMAN		1179										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						TTTTGTCTTCGTATACAGATT	0.289000													30	51					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75822986	75822986	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:75822986G>A	ENST00000322507.8	-	51	8193	c.7884C>T	c.(7882-7884)ggC>ggT	p.G2628G	COL12A1_ENST00000483888.2_Silent_p.G2628G|COL12A1_ENST00000416123.2_Silent_p.G2628G|COL12A1_ENST00000345356.6_Silent_p.G1464G	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2628	Nonhelical region (NC3).|TSP N-terminal.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TTTGCACCTCGCCTCTTGTAT	0.279000													4	19					0	0	1	0	0
TMED6	146456	broad.mit.edu	37	16	69377529	69377529	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:69377529C>A	ENST00000288025.3	-	4	559	c.504G>T	c.(502-504)aaG>aaT	p.K168N	RP11-343C2.7_ENST00000564737.1_Intron|RP11-343C2.9_ENST00000563634.1_Intron	NM_144676.3	NP_653277.2	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain containing 6	168					transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|kidney(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	9						TGTTCTGCACCTTTTGTGTGC	0.443000													49	80					6.27289e-28	7.01837e-28	1	1	0
MED13L	23389	broad.mit.edu	37	12	116446684	116446684	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:116446684C>A	ENST00000281928.3	-	10	1740	c.1534G>T	c.(1534-1536)Ggg>Tgg	p.G512W		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	512					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GAGTCTATCCCTGCCAACCCT	0.453000													17	16					1.15088e-07	1.20771e-07	1	1	0
ARMC9	80210	broad.mit.edu	37	2	232123790	232123790	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:232123790C>T	ENST00000349938.4	+	11	1195	c.1001C>T	c.(1000-1002)gCc>gTc	p.A334V	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.3	NP_001258395.1|NP_079415.3	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	334							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		CGCTTGAAAGCCTTCTTGTTG	0.448000													4	47					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31324984	31324984	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:31324984C>T	ENST00000269197.5	+	12	5172	c.5172C>T	c.(5170-5172)acC>acT	p.T1724T		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1724					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CCTTGGCTACCGATGCCCTGA	0.557000													3	34					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39760173	39760173	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:39760173G>A	ENST00000395670.3	-	6	1301	c.882C>T	c.(880-882)ggC>ggT	p.G294G	KIF21A_ENST00000544797.2_Silent_p.G294G|KIF21A_ENST00000541463.2_Silent_p.G294G|KIF21A_ENST00000361418.5_Silent_p.G294G|KIF21A_ENST00000361961.3_Silent_p.G294G			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	294	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TGATAGAAATGCCTTCTTTTG	0.383000													11	30					0	0	1	0	0
NAA15	80155	broad.mit.edu	37	4	140306049	140306049	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:140306049G>A	ENST00000296543.5	+	18	2542	c.2219G>A	c.(2218-2220)cGt>cAt	p.R740H	NAA15_ENST00000398947.1_Missense_Mutation_p.R739H	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	740					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						GAAATGAATCGTCTTTTTGGA	0.279000													23	24					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143096397	143096397	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:143096397G>A	ENST00000275815.3	-	5	1031	c.945C>T	c.(943-945)agC>agT	p.S315S		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	315	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TGTAATGGCCGCTCTCACAGG	0.652000													9	19					0	0	1	0	0
RBM34	23029	broad.mit.edu	37	1	235301420	235301420	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:235301420C>T	ENST00000408888.3	-	7	1001	c.771G>A	c.(769-771)acG>acA	p.T257T	RBM34_ENST00000366606.3_Silent_p.T252T			P42696	RBM34_HUMAN	RNA binding motif protein 34	257	RRM 1.					nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			TCAATGCTTGCGTGGCAGCAC	0.313000													14	21					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109814061	109814061	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109814061T>C	ENST00000271332.3	+	27	7791	c.7730T>C	c.(7729-7731)cTg>cCg	p.L2577P	CELSR2_ENST00000498157.1_3'UTR	NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	2577					dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GCCACGTGGCTGCTGGCACTG	0.632000													6	77					0	0	1	0	0
PLEKHA4	0	broad.mit.edu	37	19	49362848	49362848	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49362848G>A	ENST00000263265.6	-	7	1125	c.570C>T	c.(568-570)cgC>cgT	p.R190R	PLEKHA4_ENST00000596713.1_5'UTR|PLEKHA4_ENST00000355496.5_Silent_p.R190R	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	190	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		ATTCTGAGATGCGCCCCTCTT	0.677000													23	37					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162608	33162608	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:33162608C>T	ENST00000510327.1	-	0	346																											GACAGCACACCGTGCCGACAG	0.488000													6	13					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121028673	121028673	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:121028673C>T	ENST00000392793.1	+	14	4700	c.4429C>T	c.(4429-4431)Cgc>Tgc	p.R1477C	TECTA_ENST00000264037.2_Missense_Mutation_p.R1477C			O75443	TECTA_HUMAN	tectorin alpha	1477					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CAACGGGGTGCGCGGCTGCTT	0.687000													10	29					0	0	1	0	0
AP4M1	9179	broad.mit.edu	37	7	99702674	99702674	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99702674G>A	ENST00000429084.1	+	9	859	c.701G>A	c.(700-702)cGc>cAc	p.R234H	AP4M1_ENST00000422582.1_Missense_Mutation_p.R99H|AP4M1_ENST00000359593.4_Missense_Mutation_p.R227H|AP4M1_ENST00000421755.1_Missense_Mutation_p.R227H			O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	227	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACAGAGATGCGCATTGGCTTG	0.542000													9	33					0	0	1	0	0
IL1R2	7850	broad.mit.edu	37	2	102626274	102626274	+	Silent	SNP	C	C	T	rs142963191	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:102626274C>T	ENST00000332549.3	+	3	547	c.318C>T	c.(316-318)taC>taT	p.Y106Y	IL1R2_ENST00000441002.1_Silent_p.Y106Y|IL1R2_ENST00000393414.2_Silent_p.Y106Y	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	106	Ig-like C2-type 1.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	CTGGCACCTACGTCTGCACTA	0.597000													32	44					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34190279	34190279	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:34190279G>T	ENST00000373381.4	-	18	2898	c.2722C>A	c.(2722-2724)Ctg>Atg	p.L908M		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	868	Sushi 5.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCTGGATCCAGACAGTGGTCT	0.527000													20	36					7.21436e-19	7.96902e-19	1	1	0
YTHDF2	51441	broad.mit.edu	37	1	29069960	29069960	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:29069960G>A	ENST00000373812.3	+	4	1540	c.1178G>A	c.(1177-1179)cGg>cAg	p.R393Q	YTHDF2_ENST00000542507.1_Missense_Mutation_p.R393Q|YTHDF2_ENST00000541996.1_Missense_Mutation_p.R343Q|YTHDF2_ENST00000478283.1_3'UTR	NM_016258.2	NP_057342.2	Q9Y5A9	YTHD2_HUMAN	YTH domain family, member 2	393					humoral immune response					NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		GAGAAGCTTCGGTCCATTAAT	0.473000													46	49					0	0	1	0	0
GRIA1	0	broad.mit.edu	37	5	153149800	153149800	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:153149800A>T	ENST00000285900.5	+	13	2438	c.2095A>T	c.(2095-2097)Acc>Tcc	p.T699S	GRIA1_ENST00000518142.1_Missense_Mutation_p.T619S|GRIA1_ENST00000340592.5_Missense_Mutation_p.T699S|GRIA1_ENST00000521843.2_Missense_Mutation_p.T630S|GRIA1_ENST00000518783.1_Missense_Mutation_p.T709S|GRIA1_ENST00000448073.4_Missense_Mutation_p.T709S	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	699					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TTTTGTGCGGACCACAGAGGA	0.473000													23	27					0	0	1	0	0
PER2	8864	broad.mit.edu	37	2	239176769	239176769	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:239176769G>A	ENST00000254657.3	-	8	1174	c.895C>T	c.(895-897)Cgg>Tgg	p.R299W	PER2_ENST00000355768.2_Missense_Mutation_p.R299W|PER2_ENST00000254658.3_Missense_Mutation_p.R299W|PER2_ENST00000440245.1_Missense_Mutation_p.R299W	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	299					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TGTTGGTCCCGCACCTTGACC	0.582000													12	18					0	0	1	0	0
TMEM11	8834	broad.mit.edu	37	17	21101727	21101727	+	Silent	SNP	G	G	A	rs150424039	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:21101727G>A	ENST00000317635.5	-	2	960	c.489C>T	c.(487-489)gaC>gaT	p.D163D	TMEM11_ENST00000584432.1_5'UTR	NM_003876.2	NP_003867.1	P17152	TMM11_HUMAN	transmembrane protein 11	163					mitochondrion organization	integral to mitochondrial inner membrane|integral to plasma membrane	protein binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	5						TGTGCAGGTCGTCCTTCCGGA	0.537000													64	56					0	0	1	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389230	1389230	+	Missense_Mutation	SNP	G	G	A	rs71299249		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1389230G>A	ENST00000324803.4	+	1	3891	c.931G>A	c.(931-933)Gcc>Acc	p.A311T		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	311					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding	p.P310fs*95(1)		NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			TGGAGTGCCCGCCTGCTCACG	0.672000													112	136					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168114118	168114118	+	Silent	SNP	G	G	A	rs148473454	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:168114118G>A	ENST00000519560.1	-	30	3599	c.3180C>T	c.(3178-3180)tgC>tgT	p.C1060C	SLIT3_ENST00000404867.3_Silent_p.C1060C|SLIT3_ENST00000332966.8_Silent_p.C1067C	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1060	EGF-like 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding	p.C1060C(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGACACACTCGCAGCTGGAAC	0.612000													8	15					0	0	1	0	0
ZNF324	25799	broad.mit.edu	37	19	58982235	58982235	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58982235C>T	ENST00000536459.2	+	4	1085	c.376C>T	c.(376-378)Cgg>Tgg	p.R126W	ZNF324_ENST00000196482.3_Missense_Mutation_p.R126W			O75467	Z324A_HUMAN	zinc finger protein 324	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCAGAGACAACGGGGTGCCTC	0.602000													7	66					0	0	1	0	0
DNAI2	64446	broad.mit.edu	37	17	72306164	72306164	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72306164C>T	ENST00000579490.1	+	10	1662	c.1527C>T	c.(1525-1527)gaC>gaT	p.D509D	DNAI2_ENST00000446837.2_Silent_p.D452D|DNAI2_ENST00000582036.1_Intron|DNAI2_ENST00000307504.5_Silent_p.D309D|DNAI2_ENST00000311014.6_Silent_p.D452D			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	452					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						AGGTGTGTGACGAGGCCCTCT	0.617000									Kartagener syndrome				16	27					0	0	1	0	0
PRKAR1B	5575	broad.mit.edu	37	7	590210	590210	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:590210G>A	ENST00000406797.1	-	11	1177	c.1003C>T	c.(1003-1005)Cgg>Tgg	p.R335W	PRKAR1B_ENST00000537384.1_Missense_Mutation_p.R335W|PRKAR1B_ENST00000360274.4_Missense_Mutation_p.R335W|PRKAR1B_ENST00000403562.1_Missense_Mutation_p.R335W|PRKAR1B_ENST00000544935.1_Missense_Mutation_p.R335W	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	335					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		GTGGCCGCCCGGGGCCGGTTC	0.667000													3	8					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94066493	94066493	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:94066493A>G	ENST00000369303.4	-	5	1450	c.1266T>C	c.(1264-1266)tcT>tcC	p.S422S		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	422	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GGCTTAAGTCAGAAACTCCAT	0.433000													7	23					0	0	1	0	0
KDM1B	221656	broad.mit.edu	37	6	18212817	18212817	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:18212817C>T	ENST00000388870.2	+	18	2209	c.1968C>T	c.(1966-1968)ggC>ggT	p.G656G	KDM1B_ENST00000546309.2_Intron|KDM1B_ENST00000397244.1_Silent_p.G424G|KDM1B_ENST00000297792.5_Silent_p.G423G			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	655					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						ACAGCTTAGGCGCAGGCATCA	0.413000													17	76					0	0	1	0	0
APOL2	23780	broad.mit.edu	37	22	36624274	36624274	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36624274C>T	ENST00000249066.6	-	6	666	c.190G>A	c.(190-192)Gtc>Atc	p.V64I	APOL2_ENST00000451256.2_Missense_Mutation_p.V176I|APOL2_ENST00000358502.5_Missense_Mutation_p.V64I	NM_145637.1	NP_663612.1	Q9BQE5	APOL2_HUMAN	apolipoprotein L, 2	64					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(2)	9						TCCTTCATGACCATGTGACTT	0.458000													6	160					0	0	1	0	0
KAT7	11143	broad.mit.edu	37	17	47899039	47899039	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:47899039G>A	ENST00000503935.2	+	11	1841	c.805G>A	c.(805-807)Gcc>Acc	p.A269T	KAT7_ENST00000259021.4_Missense_Mutation_p.A425T|KAT7_ENST00000510819.1_Missense_Mutation_p.A256T|KAT7_ENST00000513980.1_3'UTR|KAT7_ENST00000435742.2_Missense_Mutation_p.A239T|KAT7_ENST00000424009.2_Missense_Mutation_p.A395T|KAT7_ENST00000509773.1_Missense_Mutation_p.A315T|KAT7_ENST00000454930.2_Missense_Mutation_p.A286T			O95251	MYST2_HUMAN	K(lysine) acetyltransferase 7	425					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding										GTGCCTGTTGGCCAAACTTTT	0.448000													32	61					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169791908	169791908	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:169791908G>A	ENST00000263817.6	-	23	2966	c.2842C>T	c.(2842-2844)Cgc>Tgc	p.R948C		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	948	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GCAACAGTGCGGATGTTACTG	0.438000													49	85					0	0	1	0	0
CSF1	1435	broad.mit.edu	37	1	110466717	110466717	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110466717C>T	ENST00000329608.6	+	6	1865	c.1474C>T	c.(1474-1476)Cag>Tag	p.Q492*	CSF1_ENST00000344188.5_Nonsense_Mutation_p.Q376*|CSF1_ENST00000369802.3_Nonsense_Mutation_p.Q492*|CSF1_ENST00000369801.1_Nonsense_Mutation_p.Q376*|CSF1_ENST00000420111.2_Nonsense_Mutation_p.Q194*	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	492					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTTCAGCCCGCAGCTCCAGGA	0.622000													14	30					0	0	1	0	0
LIPC	3990	broad.mit.edu	37	15	58830636	58830636	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:58830636C>T	ENST00000414170.3	+	3	480	c.193C>T	c.(193-195)Cga>Tga	p.R65*	LIPC_ENST00000433326.2_Nonsense_Mutation_p.R65*|LIPC_ENST00000356113.6_Nonsense_Mutation_p.R65*|LIPC_ENST00000299022.5_Nonsense_Mutation_p.R65*			P11150	LIPC_HUMAN	lipase, hepatic	65					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity	p.R65*(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		CTGTCAGATTCGAATCAATCA	0.488000													53	74					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47988033	47988033	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:47988033G>A	ENST00000289672.2	-	1	55	c.5C>T	c.(4-6)gCc>gTc	p.A2V		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TGCCTCCTCGGCCATGTCCTG	0.453000													19	23					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61527732	61527732	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:61527732G>A	ENST00000266070.4	-	8	2392	c.2067C>T	c.(2065-2067)agC>agT	p.S689S	DIDO1_ENST00000395343.1_Silent_p.S689S|DIDO1_ENST00000395340.1_Silent_p.S689S|DIDO1_ENST00000395335.2_Silent_p.S689S	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	689	TFIIS central.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TTAAGTCATCGCTGTCATTGA	0.358000													24	25					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57559687	57559687	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57559687A>G	ENST00000243077.3	+	16	3096	c.2630A>G	c.(2629-2631)aAc>aGc	p.N877S		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	877	LDL-receptor class A 3.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GACGGAGACAACGATTGCCTG	0.652000													19	19					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97427091	97427091	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:97427091C>T	ENST00000377075.2	+	1	453	c.355C>T	c.(355-357)Cag>Tag	p.Q119*		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	119					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						GGTCGTCCAGCAGCTGGTCAA	0.617000													10	15					0	0	1	0	0
HSF1	3297	broad.mit.edu	37	8	145535865	145535865	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145535865C>A	ENST00000528838.1	+	9	1237	c.1077C>A	c.(1075-1077)ggC>ggA	p.G359G	HSF1_ENST00000400780.4_Silent_p.G294G	NM_005526.2	NP_005517.1	Q00613	HSF1_HUMAN	heat shock transcription factor 1	359						cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(3)|prostate(3)|skin(1)|urinary_tract(2)	11	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			ACACCGAGGGCCGGCCTCCCT	0.716000													5	9					0.00116845	0.0011864	1	1	0
TMEM8A	58986	broad.mit.edu	37	16	422215	422215	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:422215C>T	ENST00000431232.2	-	13	2248	c.2088G>A	c.(2086-2088)ctG>ctA	p.L696L	TMEM8A_ENST00000250930.3_Silent_p.L503L	NM_021259.2	NP_067082.2	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8A	696					cell adhesion	integral to plasma membrane				central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	14						AGACGCCGGGCAGGAGGTAGA	0.612000													4	23					0	0	1	0	0
ARMCX2	9823	broad.mit.edu	37	X	100912112	100912112	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:100912112G>A	ENST00000328766.5	-	5	916	c.463C>T	c.(463-465)Cct>Tct	p.P155S	ARMCX2_ENST00000330154.2_Missense_Mutation_p.P155S|ARMCX2_ENST00000356824.4_Missense_Mutation_p.P155S	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	155	Ala-rich.					integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						GCCATTGCAGGGGCTTCTGCA	0.642000													39	4					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202574743	202574743	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:202574743G>A	ENST00000264276.6	-	27	4513	c.4141C>T	c.(4141-4143)Cac>Tac	p.H1381Y	ALS2_ENST00000457679.2_3'UTR	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	1381					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						CCCAGGGGGTGCAGAGGAGTG	0.473000													7	19					0	0	1	0	0
SACM1L	22908	broad.mit.edu	37	3	45746682	45746682	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:45746682C>T	ENST00000541314.1	+	3	193	c.131C>T	c.(130-132)gCa>gTa	p.A44V	SACM1L_ENST00000464524.1_3'UTR|SACM1L_ENST00000418611.1_5'UTR|SACM1L_ENST00000389061.5_Silent_p.G62G			Q9NTJ5	SAC1_HUMAN	SAC1 suppressor of actin mutations 1-like (yeast)	0						Golgi apparatus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		GTATACTGGGCACAATCCATC	0.353000													27	52					0	0	1	0	0
ZNF526	116115	broad.mit.edu	37	19	42729173	42729173	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42729173C>T	ENST00000301215.3	+	3	843	c.618C>T	c.(616-618)tgC>tgT	p.C206C		NM_133444.1	NP_597701.1	Q8TF50	ZN526_HUMAN	zinc finger protein 526	206	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(3)	22		Prostate(69;0.0704)				CTACCCTCTGCGCCACCCCTG	0.587000													42	64					0	0	1	0	0
STK38L	23012	broad.mit.edu	37	12	27450705	27450705	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:27450705C>T	ENST00000389032.3	+	2	221	c.52C>T	c.(52-54)Cgg>Tgg	p.R18W	STK38L_ENST00000539577.1_Intron	NM_015000.3	NP_055815.1	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	18					intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.R18W(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12	Colorectal(261;0.0847)					CAACCATACCCGGGAAAGAGT	0.403000													38	48					0	0	1	0	0
MOB3C	148932	broad.mit.edu	37	1	47075832	47075832	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47075832G>T	ENST00000371940.1	-	2	3606	c.532C>A	c.(532-534)Ctg>Atg	p.L178M	MOB3C_ENST00000477318.1_5'UTR|MOB3C_ENST00000319928.3_Missense_Mutation_p.L155M|MKNK1_ENST00000545730.1_Intron|MOB3C_ENST00000271139.8_Missense_Mutation_p.L207M			Q70IA8	MOL2C_HUMAN	MOB kinase activator 3C	155							metal ion binding										AGGCGGGTCAGGATCTTGGTG	0.567000													18	24					3.52763e-06	3.66169e-06	1	1	0
SYCP2	10388	broad.mit.edu	37	20	58476773	58476773	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:58476773C>T	ENST00000357552.3	-	16	1351	c.1126G>A	c.(1126-1128)Gca>Aca	p.A376T	SYCP2_ENST00000371001.2_Missense_Mutation_p.A376T			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	376					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TCTAGTGATGCGTCAAAATAC	0.274000													16	44					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31139109	31139109	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:31139109C>T	ENST00000538351.1	-	7	832	c.78G>A	c.(76-78)atG>atA	p.M26I	ZNF438_ENST00000331737.6_Missense_Mutation_p.M65I|ZNF438_ENST00000436087.2_Missense_Mutation_p.M75I|ZNF438_ENST00000444692.2_Missense_Mutation_p.M65I|ZNF438_ENST00000452305.1_Missense_Mutation_p.M65I|ZNF438_ENST00000361310.3_Missense_Mutation_p.M75I|ZNF438_ENST00000375311.1_Intron|ZNF438_ENST00000442986.1_Missense_Mutation_p.M75I|ZNF438_ENST00000413025.1_Missense_Mutation_p.M75I	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	75					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				TCTGGGTGGACATCCCCAGCA	0.532000													7	82					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64678561	64678561	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64678561A>G	ENST00000421419.2	-	10	1529	c.1415T>C	c.(1414-1416)tTc>tCc	p.F472S	ATG2A_ENST00000377264.3_Missense_Mutation_p.F472S			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	472							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						AAGGTGATGGAAGTCTCGGGA	0.597000													7	22					0	0	1	0	0
RBM39	9584	broad.mit.edu	37	20	34309768	34309768	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:34309768T>C	ENST00000361162.6	-	9	1103	c.719A>G	c.(718-720)aAc>aGc	p.N240S	RBM39_ENST00000253363.6_Missense_Mutation_p.N240S|RBM39_ENST00000528062.3_Missense_Mutation_p.N218S|RBM39_ENST00000407261.4_Missense_Mutation_p.N83S	NM_004902.3|NM_184234.2	NP_004893.1|NP_909122.1	Q14498	RBM39_HUMAN	RNA binding motif protein 39	240					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					TTGTAAATTGTTTGCCATTGC	0.408000													20	36					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37692065	37692065	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37692065C>A	ENST00000248901.6	+	4	380	c.193C>A	c.(193-195)Ctg>Atg	p.L65M	CYTH4_ENST00000402997.1_Missense_Mutation_p.L65M|CYTH4_ENST00000405206.3_Missense_Mutation_p.L65M|CYTH4_ENST00000439667.1_3'UTR	NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	65	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						GGAGAAGGAGCTGTGTATTGG	0.637000													6	16					5.9392e-07	6.20451e-07	1	1	0
PCDHGA6	0	broad.mit.edu	37	5	140753679	140753679	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140753679G>A	ENST00000517434.1	+	1	29	c.29G>A	c.(28-30)cGc>cAc	p.R10H	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCCGCAGCGCAGCGAGCAG	0.587000													3	9					0	0	1	0	0
EFHB	151651	broad.mit.edu	37	3	19921210	19921210	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:19921210G>A	ENST00000295824.9	-	13	2576	c.2415C>T	c.(2413-2415)caC>caT	p.H805H	EFHB_ENST00000344838.4_Silent_p.H675H	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	805					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						CTTCTCCTCTGTGATGCTTTT	0.368000													34	70					0	0	1	0	0
TTLL13	440307	broad.mit.edu	37	15	90802028	90802028	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:90802028G>T	ENST00000438251.1	+	10	1511	c.1221G>T	c.(1219-1221)aaG>aaT	p.K407N	RP11-697E2.6_ENST00000561573.1_3'UTR|TTLL13_ENST00000339615.5_Missense_Mutation_p.K407N			A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	407	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	16	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			AAGAAGTAAAGGATGCACTTC	0.512000													31	71					9.65021e-13	1.04556e-12	1	1	0
TIAM1	7074	broad.mit.edu	37	21	32554924	32554924	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:32554924G>A	ENST00000286827.3	-	16	3172	c.2701C>T	c.(2701-2703)Cgt>Tgt	p.R901C	TIAM1_ENST00000541036.1_Missense_Mutation_p.R841C	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	901	PDZ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TCAGCAGCACGATTATTGATC	0.488000													12	9					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112622030	112622030	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112622030G>T	ENST00000550722.1	-	61	10697	c.10302C>A	c.(10300-10302)ccC>ccA	p.P3434P	HECTD4_ENST00000377560.5_Silent_p.P3408P|HECTD4_ENST00000430131.2_Silent_p.P3158P	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GGGCGGCGAGGGGCTGGTTGT	0.607000													14	113					2.32078e-09	2.46314e-09	1	1	0
C18orf25	147339	broad.mit.edu	37	18	43796461	43796461	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:43796461T>C	ENST00000282059.6	+	2	989	c.615T>C	c.(613-615)agT>agC	p.S205S	C18orf25_ENST00000321319.6_Silent_p.S205S	NM_145055.3	NP_659492.1	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	205										central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						AGGACAGTAGTACCAGTGATA	0.498000													16	20					0	0	1	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332424	71332424	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:71332424G>A	ENST00000242462.4	-	2	405	c.376C>T	c.(376-378)Cgc>Tgc	p.R126C		NM_020999.3	NP_066279.2	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	126	Helix-loop-helix motif.				central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity	p.R126C(1)		endometrium(4)|large_intestine(2)|lung(6)|prostate(1)	13						TGGGCGAAGCGCAGCGTCTCG	0.652000													7	32					0	0	1	0	0
TXNDC8	255220	broad.mit.edu	37	9	113100054	113100054	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:113100054G>A	ENST00000374507.4	-	1	73	c.24_splice	c.e1+1	p.T8_splice	TXNDC8_ENST00000374510.4_Splice_Site_p.T8_splice|TXNDC8_ENST00000423740.2_Splice_Site_p.T8_splice|TXNDC8_ENST00000374511.3_Splice_Site_p.T8_splice			Q6A555	TXND8_HUMAN	thioredoxin domain containing 8 (spermatozoa)	8	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	Golgi apparatus	electron carrier activity|protein disulfide oxidoreductase activity	p.T8R(1)		endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	4						AATACTTGCCGTGTCTTTAAT	0.368000													10	22					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24532702	24532702	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24532702G>A	ENST00000342740.5	+	31	3093	c.2939G>A	c.(2938-2940)cGc>cAc	p.R980H	LRRC16B_ENST00000334420.7_Missense_Mutation_p.R76H	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	980										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GGGAGGCCCCGCCCCCCCAGG	0.597000													5	21					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35563696	35563696	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:35563696C>T	ENST00000353139.5	-	32	4430		c.e32+1		ACACA_ENST00000394406.2_Splice_Site|ACACA_ENST00000360679.3_Splice_Site|ACACA_ENST00000335166.5_Splice_Site	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha						acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GGACATTATACCTTATCCTCA	0.443000													15	19					0	0	1	0	0
IRAK3	0	broad.mit.edu	37	12	66638758	66638758	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:66638758G>A	ENST00000261233.4	+	10	1538	c.1117G>A	c.(1117-1119)Gta>Ata	p.V373I	IRAK3_ENST00000457197.2_Missense_Mutation_p.V312I	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	373	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		AGGATGTAGAGTAGTGTTAGA	0.318000													34	45					0	0	1	0	0
CSPG5	10675	broad.mit.edu	37	3	47618849	47618849	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47618849C>T	ENST00000383738.2	-	2	2765	c.667G>A	c.(667-669)Gca>Aca	p.A223T	CSPG5_ENST00000456150.1_Missense_Mutation_p.A85T|CSPG5_ENST00000264723.4_Missense_Mutation_p.A223T	NM_001206943.1|NM_001206945.1	NP_001193872.1|NP_001193874.1	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan C)	223					cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	22				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CCCAGATCTGCGCCACGACCC	0.557000													5	13					0	0	1	0	0
LEP	3952	broad.mit.edu	37	7	127894591	127894591	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:127894591C>T	ENST00000308868.4	+	3	330	c.279C>T	c.(277-279)aaC>aaT	p.N93N		NM_000230.2	NP_000221.1	P41159	LEP_HUMAN	leptin	93					adult feeding behavior|energy reserve metabolic process|negative regulation of appetite|placenta development|positive regulation of developmental growth	extracellular space				endometrium(1)|large_intestine(2)|lung(5)	8						CTTCCAGAAACGTGATCCAAA	0.547000													13	55					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81060603	81060603	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:81060603C>T	ENST00000334512.5	+	17	2495	c.1923C>T	c.(1921-1923)cgC>cgT	p.R641R		NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	641					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CCATTGAGCGCGGCGACAACA	0.642000													15	20					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102487001	102487001	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:102487001C>A	ENST00000321521.9	+	9	1524	c.951C>A	c.(949-951)tcC>tcA	p.S317S	PPIP5K2_ENST00000414217.1_Silent_p.S317S|PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000358359.3_Silent_p.S317S			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	317					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						ATGGACAGTCCTATGTCTGTG	0.294000													33	53					1.36615e-20	1.51493e-20	1	1	0
CNTRL	11064	broad.mit.edu	37	9	123912636	123912636	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:123912636A>G	ENST00000373855.1	+	25	4098	c.3838A>G	c.(3838-3840)Act>Gct	p.T1280A	CNTRL_ENST00000373850.1_Missense_Mutation_p.T728A|CNTRL_ENST00000238341.5_Missense_Mutation_p.T1280A|CNTRL_ENST00000373847.1_Missense_Mutation_p.T728A			Q7Z7A1	CNTRL_HUMAN	centriolin	1280	Pro-rich.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						CACCCCTGGCACTGTTGTTTA	0.587000													23	36					0	0	1	0	0
DUS1L	64118	broad.mit.edu	37	17	80016226	80016226	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80016226C>A	ENST00000354321.7	-	12	1758	c.1273G>T	c.(1273-1275)Gac>Tac	p.D425Y	DUS1L_ENST00000306796.5_Missense_Mutation_p.D425Y			Q6P1R4	DUS1L_HUMAN	dihydrouridine synthase 1-like (S. cerevisiae)	425					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|endometrium(1)|lung(2)|ovary(1)|skin(1)	6	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			CCTGGGCAGTCTGCAGTCTCT	0.657000													16	87					4.7546e-09	5.0353e-09	1	1	0
SSBP4	170463	broad.mit.edu	37	19	18538785	18538785	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18538785A>G	ENST00000270061.6	+	4	492	c.272A>G	c.(271-273)cAg>cGg	p.Q91R	SSBP4_ENST00000348495.5_Missense_Mutation_p.Q91R	NM_032627.4	NP_116016.1	Q9BWG4	SSBP4_HUMAN	single stranded DNA binding protein 4	91						nucleus	single-stranded DNA binding			endometrium(2)|kidney(1)|skin(1)	4						AAGGCCTTCCAGGACTATGTG	0.682000													16	17					0	0	1	0	0
OR51B4	79339	broad.mit.edu	37	11	5322930	5322930	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5322930G>T	ENST00000380224.1	-	1	296	c.247C>A	c.(247-249)Ctg>Atg	p.L83M	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTAGCAGCAGGACACCCAGG	0.512000													14	29					0.000151284	0.000155038	1	1	0
ENDOD1	23052	broad.mit.edu	37	11	94862713	94862713	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:94862713G>T	ENST00000278505.4	+	2	1591	c.1473G>T	c.(1471-1473)aaG>aaT	p.K491N		NM_015036.2	NP_055851.1	O94919	ENDD1_HUMAN	endonuclease domain containing 1	491						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				TTGGCTACAAGGTTACTTTTG	0.423000													15	67					3.45872e-05	3.56558e-05	1	1	0
GAS7	8522	broad.mit.edu	37	17	9823007	9823007	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:9823007C>T	ENST00000396115.1	-	12	1284	c.974G>A	c.(973-975)cGc>cAc	p.R325H	GAS7_ENST00000542249.1_Missense_Mutation_p.R330H|GAS7_ENST00000437099.2_Missense_Mutation_p.R321H|GAS7_ENST00000580865.1_Missense_Mutation_p.R245H|GAS7_ENST00000579158.1_Missense_Mutation_p.R337H|GAS7_ENST00000585266.1_Missense_Mutation_p.R321H|GAS7_ENST00000432992.2_Missense_Mutation_p.R385H|GAS7_ENST00000323816.4_Missense_Mutation_p.R321H|GAS7_ENST00000583882.1_Intron|GAS7_ENST00000540214.1_Intron	NM_201432.1	NP_958836.1	O60861	GAS7_HUMAN	growth arrest-specific 7	385					cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(7)|lung(18)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	39						ATCCACACAGCGCATGAGGTC	0.547000			T	MLL	AML*								4	78					0	0	1	0	0
BHMT	635	broad.mit.edu	37	5	78421875	78421875	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:78421875C>T	ENST00000274353.5	+	6	739	c.632C>T	c.(631-633)tCc>tTc	p.S211F	DMGDH_ENST00000520388.1_Intron|BHMT_ENST00000524080.1_Missense_Mutation_p.S58F	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	211	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding	p.S211Y(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	ACAGGAGCATCCATCATTGGT	0.493000													18	27					0	0	1	0	0
AE000661.37	0	broad.mit.edu	37	14	22935300	22935300	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22935300C>T	ENST00000514473.2	-	0	225				AE000661.37_ENST00000556777.1_RNA																							gaattagctccctctgagttc	0.383000													5	58					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42111443	42111443	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42111443G>T	ENST00000457542.2	+	21	2577		c.e21-1		MAPKBP1_ENST00000260357.7_Splice_Site|MAPKBP1_ENST00000514566.1_Splice_Site|MAPKBP1_ENST00000221214.6_Splice_Site|MAPKBP1_ENST00000456763.2_Splice_Site	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1											breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CTCGGACTCAGGCACCAGGCC	0.562000													37	26					4.07013e-28	4.55483e-28	1	1	0
ANXA9	8416	broad.mit.edu	37	1	150960778	150960778	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:150960778A>G	ENST00000368947.4	+	12	1289	c.813A>G	c.(811-813)acA>acG	p.T271T		NM_003568.2	NP_003559.2	O76027	ANXA9_HUMAN	annexin A9	271					cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(4)|skin(2)	8	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCAAGAACACACCGCTGTACT	0.502000													10	95					0	0	1	0	0
SLC25A37	51312	broad.mit.edu	37	8	23423843	23423843	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:23423843G>A	ENST00000519973.1	+	2	631	c.433G>A	c.(433-435)Gcc>Acc	p.A145T	SLC25A37_ENST00000517923.1_3'UTR	NM_016612.2	NP_057696.2	Q9NYZ2	MFRN1_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 37	145					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				NS(1)|endometrium(3)|large_intestine(2)|lung(8)|urinary_tract(1)	15		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)		CAGCCACCTAGCCAACGGTAT	0.507000													4	14					0	0	1	0	0
GH1	2688	broad.mit.edu	37	17	61995794	61995794	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61995794G>A	ENST00000323322.5	-	2	125	c.83C>T	c.(82-84)cCa>cTa	p.P28L	GH1_ENST00000458650.2_Missense_Mutation_p.P28L|GH1_ENST00000342364.4_Missense_Mutation_p.P28L|GH1_ENST00000351388.4_Missense_Mutation_p.P28L|CSHL1_ENST00000392824.4_Intron	NM_000515.3	NP_000506.2	P01241	SOMA_HUMAN	growth hormone 1	28					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	19						GGGAATGGTTGGGAAGGCACT	0.592000													28	120					0	0	1	0	0
TPP1	1200	broad.mit.edu	37	11	6640086	6640086	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6640086G>T	ENST00000299427.6	-	3	210	c.150C>A	c.(148-150)acC>acA	p.T50T	TPP1_ENST00000528657.1_3'UTR|TPP1_ENST00000534644.1_Intron|RP11-732A19.9_ENST00000545572.1_RNA|TPP1_ENST00000533371.1_5'UTR	NM_000391.3	NP_000382.3	O14773	TPP1_HUMAN	tripeptidyl peptidase I	50					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		TCAGGGCAAAGGTGAGACTCA	0.607000													21	23					3.5997e-14	3.92294e-14	1	1	0
VRK1	7443	broad.mit.edu	37	14	97322895	97322895	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:97322895C>T	ENST00000216639.3	+	10	1010	c.861C>T	c.(859-861)gaC>gaT	p.D287D		NM_003384.2	NP_003375.1	Q99986	VRK1_HUMAN	vaccinia related kinase 1	287	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(1)|stomach(1)	12		Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.234)		GTTTGATGGACAAATGTTTTC	0.308000													10	23					0	0	1	0	0
KRT16	3868	broad.mit.edu	37	17	39768447	39768447	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39768447C>A	ENST00000301653.4	-	1	558	c.494G>T	c.(493-495)aGt>aTt	p.S165I		NM_005557.3	NP_005548.2	P08779	K1C16_HUMAN	keratin 16	165	Linker 1.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				GAAGTAGGGACTGTAGTCTTT	0.577000													23	57					3.57733e-08	3.76749e-08	1	1	0
SMOC1	64093	broad.mit.edu	37	14	70477533	70477533	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:70477533C>T	ENST00000381280.4	+	8	980	c.727C>T	c.(727-729)Cgt>Tgt	p.R243C	SMOC1_ENST00000361956.3_Missense_Mutation_p.R243C	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	243	Thyroglobulin type-1 2.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		GCAGAATCCCCGTGAGGGTAT	0.562000													17	23					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519717	113519717	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:113519717A>G	ENST00000284601.3	-	4	1498	c.1430T>C	c.(1429-1431)aTt>aCt	p.I477T		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	477					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TTTTACTTCAATATTTTTAGC	0.393000													33	45					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1118412	1118412	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1118412C>T	ENST00000379290.1	+	11	1246	c.1073C>T	c.(1072-1074)gCg>gTg	p.A358V	TTLL10_ENST00000379288.3_Missense_Mutation_p.A285V|TTLL10_ENST00000379289.1_Missense_Mutation_p.A358V			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	358	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGGCCTCAGGCGCGGGTGGTG	0.726000													9	11					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153709146	153709146	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:153709146G>A	ENST00000297107.6	+	4	553	c.416G>A	c.(415-417)cGc>cAc	p.R139H	GALNT10_ENST00000425427.2_Missense_Mutation_p.R139H|GALNT10_ENST00000377661.2_Missense_Mutation_p.R139H|SAP30L-AS1_ENST00000519727.1_RNA	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	139						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.R139H(1)		cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			AACAGCAAGCGCTACCTGGAG	0.577000													4	35					0	0	1	0	0
TMEM115	11070	broad.mit.edu	37	3	50395884	50395884	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50395884T>C	ENST00000266025.3	-	1	1157	c.611A>G	c.(610-612)tAt>tGt	p.Y204C	XXcos-LUCA11.5_ENST00000606589.1_Intron	NM_007024.4	NP_008955.1	Q12893	TM115_HUMAN	transmembrane protein 115	204					negative regulation of cell proliferation	Golgi apparatus|integral to membrane|nucleus				breast(2)|endometrium(1)|lung(1)|prostate(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GAAGCGAAGATATACCCAACT	0.632000													9	19					0	0	1	0	0
ECD	11319	broad.mit.edu	37	10	74914063	74914063	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:74914063G>A	ENST00000372979.4	-	6	940	c.734C>T	c.(733-735)gCt>gTt	p.A245V	ECD_ENST00000454759.1_Missense_Mutation_p.A245V|ECD_ENST00000430082.1_Missense_Mutation_p.A245V	NM_007265.2	NP_009196.1	O95905	SGT1_HUMAN	ecdysoneless homolog (Drosophila)	245					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(51;0.0119)					AACACGACAAGCTCGCAGGTC	0.473000													4	35					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139258061	139258061	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:139258061G>A	ENST00000406875.3	-	15	3303	c.3209C>T	c.(3208-3210)cCg>cTg	p.P1070L	HIPK2_ENST00000428878.2_Missense_Mutation_p.P1043L	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	1070	Autoinhibitory domain (AID).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					GAAGGAGTACGGAGCCTGGGC	0.687000													23	53					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987555	50987555	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50987555G>A	ENST00000395676.2	+	1	1094	c.960G>A	c.(958-960)gcG>gcA	p.A320A		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	320										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTCTACCTGCGCACCTGCATG	0.716000													33	55					0	0	1	0	0
ZNF813	126017	broad.mit.edu	37	19	53987091	53987091	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53987091G>T	ENST00000396403.4	+	2	143	c.15_splice	c.e2+1	p.Q5_splice	ZNF813_ENST00000396421.4_Splice_Site_p.Q5_splice	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		CTCTTCCTCAGGTGAGATGAT	0.463000													8	21					5.50884e-06	5.70893e-06	1	1	0
CD109	135228	broad.mit.edu	37	6	74519715	74519715	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:74519715C>G	ENST00000437994.2	+	27	3795	c.3364C>G	c.(3364-3366)Caa>Gaa	p.Q1122E	CD109_ENST00000287097.5_Missense_Mutation_p.Q1122E|CD109_ENST00000422508.2_Missense_Mutation_p.Q1045E	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	1122						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AGGTGGCATGCAATTCTGGGT	0.408000													3	33					0	0	1	0	0
ARSG	22901	broad.mit.edu	37	17	66364738	66364738	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:66364738G>A	ENST00000448504.2	+	7	1550	c.754G>A	c.(754-756)Gtg>Atg	p.V252M	ARSG_ENST00000582154.1_3'UTR|ARSG_ENST00000452479.2_Missense_Mutation_p.V88M	NM_014960.4	NP_055775.2	Q96EG1	ARSG_HUMAN	arylsulfatase G	252					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			NS(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	26			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CCACATGCACGTGCCCTTACC	0.602000													30	34					0	0	1	0	0
GRB14	2888	broad.mit.edu	37	2	165404231	165404231	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:165404231C>A	ENST00000263915.3	-	3	958	c.420G>T	c.(418-420)aaG>aaT	p.K140N	GRB14_ENST00000543549.1_Missense_Mutation_p.K53N	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	140	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						TGTAATGATTCTTCAGGATCA	0.438000													16	53					1.99824e-07	2.09433e-07	1	1	0
ARVCF	421	broad.mit.edu	37	22	19969197	19969197	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19969197C>A	ENST00000263207.3	-	5	724	c.433G>T	c.(433-435)Gga>Tga	p.G145*	ARVCF_ENST00000487793.1_5'UTR|ARVCF_ENST00000344269.3_Nonsense_Mutation_p.G82*|ARVCF_ENST00000406522.1_Nonsense_Mutation_p.G82*|ARVCF_ENST00000406259.1_Nonsense_Mutation_p.G145*|ARVCF_ENST00000401994.1_Nonsense_Mutation_p.G82*	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	145					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					AGGGGGAGTCCATCTGGGCCC	0.642000													19	36					5.35356e-11	5.74024e-11	1	1	0
CD1B	910	broad.mit.edu	37	1	158301201	158301201	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158301201G>A	ENST00000368168.3	-	1	120	c.13C>T	c.(13-15)Cca>Tca	p.P5S		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	5					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					AGTTGAAATGGCAGCAGCAGC	0.468000													9	22					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7526122	7526122	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:7526122G>A	ENST00000313599.3	-	14	3581	c.3524C>T	c.(3523-3525)gCc>gTc	p.A1175V	CD163L1_ENST00000416109.2_Missense_Mutation_p.A1185V|CD163L1_ENST00000396630.1_Missense_Mutation_p.A1175V			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1175	SRCR 11.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						GCCTGCTATGGCTGTGGTGAT	0.547000													58	82					0	0	1	0	0
FSD1	79187	broad.mit.edu	37	19	4323367	4323367	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4323367C>T	ENST00000597590.1	+	12	1294	c.1223C>T	c.(1222-1224)cCc>cTc	p.P408L	FSD1_ENST00000221856.6_Silent_p.A438A			Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing 1	406	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTACAATGCCCGCACCAAAC	0.652000													11	18					0	0	1	0	0
CELA2B	51032	broad.mit.edu	37	1	15813853	15813853	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:15813853C>T	ENST00000375910.3	+	7	738	c.713C>T	c.(712-714)aCg>aTg	p.T238M		NM_015849.2	NP_056933.2	P08218	CEL2B_HUMAN	chymotrypsin-like elastase family, member 2B	238	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)	8						GGCAGCCTCACGTCGGTCCTT	0.587000													42	31					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38119611	38119611	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38119611C>T	ENST00000406386.3	+	7	1303	c.1048C>T	c.(1048-1050)Caa>Taa	p.Q350*	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	350					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					ACGAAGCACCCAACTGGATAA	0.577000													21	81					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216074111	216074111	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:216074111G>A	ENST00000366943.2	-	39	7823	c.7437C>T	c.(7435-7437)acC>acT	p.T2479T	USH2A_ENST00000307340.3_Silent_p.T2479T|RP5-1111A8.3_ENST00000414995.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2479	Fibronectin type-III 11.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAAATCCATGGGTGGAGTCGC	0.458000										HNSCC(13;0.011)			32	46					0	0	1	0	0
KNCN	148930	broad.mit.edu	37	1	47016750	47016750	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47016750G>A	ENST00000481882.2	-	1	449	c.138C>T	c.(136-138)ggC>ggT	p.G46G	KNCN_ENST00000396314.3_Silent_p.G46G|MKNK1-AS1_ENST00000602433.1_RNA			A6PVL3	KNCN_HUMAN	kinocilin	46						integral to membrane				central_nervous_system(1)|endometrium(1)|lung(1)|ovary(1)	4	Acute lymphoblastic leukemia(166;0.155)					GAACAGCAGCGCCAATAAAGA	0.622000													24	35					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55964923	55964923	+	Missense_Mutation	SNP	C	C	T	rs1062832		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:55964923C>T	ENST00000263923.4	-	16	2609	c.2314G>A	c.(2314-2316)Gcg>Acg	p.A772T		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	772				A -> T (in Ref. 4; AAA59459/CAA43837).	angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GCAATCACCGCCGTGCCTACT	0.413000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			25	46					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39250102	39250102	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:39250102A>G	ENST00000426016.1	-	11	1553	c.1467T>C	c.(1465-1467)cgT>cgC	p.R489R	SOS1_ENST00000395038.2_Silent_p.R489R|SOS1_ENST00000472480.1_5'UTR|SOS1_ENST00000402219.2_Silent_p.R489R			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	489	PH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				TTTCTTTAAGACGATATTCTG	0.318000									Noonan syndrome				15	50					0	0	1	0	0
GFI1B	8328	broad.mit.edu	37	9	135863747	135863747	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:135863747C>T	ENST00000339463.3	+	8	1221	c.402C>T	c.(400-402)tcC>tcT	p.S134S	GFI1B_ENST00000372124.1_Silent_p.S134S|GFI1B_ENST00000372123.1_Silent_p.S134S|GFI1B_ENST00000534944.1_Silent_p.S134S|GFI1B_ENST00000372122.1_Silent_p.S134S|GFI1B_ENST00000450530.1_Silent_p.S134S			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	134	Interaction with ARIH2.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		TGGAGCACTCCGTCAGCCTGT	0.612000													14	23					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30936384	30936384	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:30936384G>A	ENST00000355537.3	+	2	2062	c.1915G>A	c.(1915-1917)Gtg>Atg	p.V639M		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	639					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CTGCGGCCGGGTGTTCCGCAC	0.632000													44	51					0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4228245	4228245	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:4228245G>A	ENST00000296358.4	-	1	371	c.347C>T	c.(346-348)gCg>gTg	p.A116V		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	116					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCGGCGGTGCGCGGAGCTGCG	0.731000													11	9					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46871632	46871632	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:46871632C>T	ENST00000433608.2	-	1	64	c.11G>A	c.(10-12)gGc>gAc	p.G4D	TTLL6_ENST00000393382.3_Intron	NM_173623.3	NP_775894.2	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	0						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						TGTTGGGGTGCCAATTCTCAT	0.522000													4	15					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128944261	128944261	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128944261T>C	ENST00000375990.3	+	39	4695	c.4292T>C	c.(4291-4293)cTg>cCg	p.L1431P	UGGT1_ENST00000259253.6_Missense_Mutation_p.L1455P			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	1455	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						AAACAGGATCTGCCCAATAAC	0.363000													42	48					0	0	1	0	0
SNX21	90203	broad.mit.edu	37	20	44469548	44469548	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:44469548G>A	ENST00000372542.1	+	3	1003	c.691G>A	c.(691-693)Gtg>Atg	p.V231M	SNX21_ENST00000491381.1_Missense_Mutation_p.V240M|SNX21_ENST00000344780.4_3'UTR|SNX21_ENST00000342644.5_Intron|SNX21_ENST00000462307.1_3'UTR			Q969T3	SNX21_HUMAN	sorting nexin family member 21	240	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|pancreas(1)	7		Myeloproliferative disorder(115;0.0122)				GGACTTCTTCGTGCTGCCGGA	0.647000													22	32					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57372341	57372341	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:57372341T>C	ENST00000361249.3	+	8	1194	c.1096_splice	c.e8-1	p.G366_splice		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	366	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CTGTTGCAGGTATTACCAGCA	0.398000													51	78					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96971776	96971776	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:96971776T>C	ENST00000341686.3	+	6	1022	c.897T>C	c.(895-897)ccT>ccC	p.P299P	C10orf129_ENST00000430183.1_Silent_p.P144P|C10orf129_ENST00000394005.3_Silent_p.P299P	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	299					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		CCTTCTGCCCTGAGACTGTTC	0.493000													12	29					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110509271	110509271	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:110509271G>A	ENST00000378402.5	+	64	10555	c.10451G>A	c.(10450-10452)tGc>tAc	p.C3484Y		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3484					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTGGACATGCTGGGATTAT	0.338000										HNSCC(38;0.096)			36	21					0	0	1	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18067046	18067046	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:18067046A>G	ENST00000506618.2	-	1	440	c.360T>C	c.(358-360)ggT>ggC	p.G120G		NM_175886.2	NP_787082.1	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	120					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					TATGATCCGCACCTGCTATAG	0.468000													19	82					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79348783	79348783	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:79348783C>T	ENST00000233735.1	+	3	263	c.160C>T	c.(160-162)Cgt>Tgt	p.R54C		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	54	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						TAATGAAGACCGTGAGACCTG	0.567000													23	90					0	0	1	0	0
MLLT6	4302	broad.mit.edu	37	17	36872797	36872797	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36872797C>T	ENST00000325718.7	+	10	1305	c.1214C>T	c.(1213-1215)cCc>cTc	p.P405L	CTB-58E17.9_ENST00000579499.1_RNA	NM_005937.3	NP_005928.2	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	405					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(7;4.43e-21)					GGCTTTGGGCCCATCATGCGC	0.677000			T	MLL	AL								24	46					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113723532	113723532	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:113723532G>A	ENST00000295878.3	-	11	2076	c.1930C>T	c.(1930-1932)Ctc>Ttc	p.L644F	KIAA1407_ENST00000545063.1_Missense_Mutation_p.L475F	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	644										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						TTCCTTCTGAGTCCAGAAAGA	0.463000													4	108					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21861824	21861824	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:21861824G>A	ENST00000399982.2	-	31	6194	c.6130C>T	c.(6130-6132)Cga>Tga	p.R2044*	CHD8_ENST00000430710.3_Nonsense_Mutation_p.R1765*|CHD8_ENST00000557364.1_Nonsense_Mutation_p.R2044*	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2044					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GGGGATACTCGCATCTCATAG	0.552000													8	18					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092278	151092278	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:151092278C>A	ENST00000370335.1	+	3	409	c.142C>A	c.(142-144)Cct>Act	p.P48T	MAGEA4_ENST00000276344.2_Missense_Mutation_p.P48T|MAGEA4_ENST00000370337.4_Missense_Mutation_p.P48T|MAGEA4_ENST00000370340.3_Missense_Mutation_p.P48T|MAGEA4_ENST00000393920.1_Missense_Mutation_p.P48T|MAGEA4_ENST00000393921.1_Missense_Mutation_p.P48T|MAGEA4_ENST00000360243.2_Missense_Mutation_p.P48T			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	48				P -> L (in Ref. 3; BAA06841).			protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCTGGTCCCTGGCACCCT	0.627000													12	11					3.07112e-06	3.18879e-06	1	1	0
SLC22A2	6582	broad.mit.edu	37	6	160662547	160662547	+	Missense_Mutation	SNP	C	C	T	rs151282335		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:160662547C>T	ENST00000366953.3	-	9	1718	c.1460G>A	c.(1459-1461)cGg>cAg	p.R487Q	SLC22A2_ENST00000491092.1_5'UTR	NM_003058.3	NP_003049.2	O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	487					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		GTTAGTGAGCCGGTAGACCAG	0.433000													31	37					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35541090	35541090	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:35541090C>T	ENST00000287272.2	+	5	616	c.596C>T	c.(595-597)cCc>cTc	p.P199L	UNC5D_ENST00000453357.2_Missense_Mutation_p.P194L|UNC5D_ENST00000416672.1_Missense_Mutation_p.P199L|UNC5D_ENST00000404895.2_Missense_Mutation_p.P199L|UNC5D_ENST00000420357.1_Missense_Mutation_p.P199L			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	199	Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AATGAAGAGCCCATTGACTCT	0.438000													6	21					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42162698	42162698	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42162698G>A	ENST00000320955.6	-	30	5735	c.5508C>T	c.(5506-5508)acC>acT	p.T1836T		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1836					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GGGTGGTCTCGGTGTCTCGGA	0.652000													11	19					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	117072862	117072862	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:117072862A>G	ENST00000356083.3	+	61	5861	c.5470A>G	c.(5470-5472)Acc>Gcc	p.T1824A		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	1824	Fibrillar collagen NC1.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						GACACTCTTCACCTTCCGGAC	0.532000													21	24					0	0	1	0	0
PPP1R27	116729	broad.mit.edu	37	17	79792477	79792477	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79792477C>T	ENST00000570394.1	-	2	339	c.243G>A	c.(241-243)aaG>aaA	p.K81K	PPP1R27_ENST00000330261.4_Silent_p.K81K			Q86WC6	DYSI1_HUMAN	protein phosphatase 1, regulatory subunit 27	81																	TGACCAGCAGCTTCACGCATT	0.622000													19	27					0	0	1	0	0
TRAV25	0	broad.mit.edu	37	14	22580421	22580421	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22580421C>T	ENST00000390454.2	+	0	122																											GCAATTGTCACGTGAGTTTGA	0.453000													25	29					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6191393	6191393	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6191393C>T	ENST00000530810.1	-	1	245	c.164G>A	c.(163-165)cGt>cAt	p.R55H	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGAAGGTTACGTTCCATGAC	0.483000													29	45					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50669577	50669577	+	Silent	SNP	G	G	A	rs116032070	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:50669577G>A	ENST00000355832.5	-	19	3882	c.3804C>T	c.(3802-3804)caC>caT	p.H1268H	ERCC6_ENST00000542458.1_Silent_p.H638H|ERCC6_ENST00000465653.1_5'UTR|RP11-123B3.2_ENST00000423283.1_RNA	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	1268					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TGATGGCATCGTGCTTCATGA	0.483000								Direct reversal of damage;Nucleotide excision repair (NER)					11	9					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70255719	70255719	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:70255719G>A	ENST00000342771.4	+	19	3838	c.3517G>A	c.(3517-3519)Gcc>Acc	p.A1173T	AUTS2_ENST00000406775.2_Missense_Mutation_p.A1149T	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	1173	His-rich.									breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CGTGCACCCCGCCTCCCTCGA	0.697000													6	8					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47431149	47431149	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:47431149G>A	ENST00000285039.7	-	20	2763	c.2464C>T	c.(2464-2466)Cat>Tat	p.H822Y		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	822	Arg-rich.|IQ 3.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		ATGCGGTAATGTTTCTGGAGC	0.617000													14	21					0	0	1	0	0
MEPE	56955	broad.mit.edu	37	4	88766450	88766450	+	Missense_Mutation	SNP	G	G	A	rs148637496		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:88766450G>A	ENST00000497649.2	+	6	736	c.358G>A	c.(358-360)Gca>Aca	p.A120T	MEPE_ENST00000424957.3_Missense_Mutation_p.A144T|MEPE_ENST00000560249.1_Missense_Mutation_p.A31T|MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000361056.3_Missense_Mutation_p.A144T|MEPE_ENST00000540395.1_Missense_Mutation_p.A31T|MEPE_ENST00000395102.4_Missense_Mutation_p.A175T			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	144					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding	p.A144T(1)		cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AGAATATGGCGCAGCTCTCAT	0.428000													17	30					0	0	1	0	0
YME1L1	10730	broad.mit.edu	37	10	27411890	27411890	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:27411890G>A	ENST00000326799.3	-	12	1434	c.1286C>T	c.(1285-1287)gCg>gTg	p.A429V	YME1L1_ENST00000375972.3_Missense_Mutation_p.A339V|YME1L1_ENST00000376016.3_Missense_Mutation_p.A372V	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	429					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						AGGAGCATTCGCCTTTGCTTC	0.328000													50	71					0	0	1	0	0
AMIGO1	57463	broad.mit.edu	37	1	110050781	110050781	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110050781A>G	ENST00000369864.4	-	2	1103	c.754T>C	c.(754-756)Tac>Cac	p.Y252H	AMIGO1_ENST00000369862.1_Missense_Mutation_p.Y252H			Q86WK6	AMGO1_HUMAN	adhesion molecule with Ig-like domain 1	252	LRRCT.				axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		TTCATGCAGTACAGATCCTCT	0.532000													4	91					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41766626	41766626	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:41766626T>C	ENST00000379483.3	-	1	2076	c.1768A>G	c.(1768-1770)Act>Gct	p.T590A		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	590							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		TCTTCCCTAGTATCATACTCA	0.418000													35	41					0	0	1	0	0
SLC25A13	10165	broad.mit.edu	37	7	95775911	95775911	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:95775911G>T	ENST00000416240.2	-	14	1602	c.1412C>A	c.(1411-1413)gCt>gAt	p.A471D	SLC25A13_ENST00000542654.1_Missense_Mutation_p.A362D|SLC25A13_ENST00000265631.5_Missense_Mutation_p.A470D	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	470					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	GACAGACAGAGCACTGACTCG	0.433000													54	80					3.07002e-29	3.43787e-29	1	1	0
PCBP2	5094	broad.mit.edu	37	12	53861054	53861054	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53861054C>T	ENST00000603815.1	+	11	1126	c.776C>T	c.(775-777)aCg>aTg	p.T259M	PCBP2_ENST00000552819.1_Missense_Mutation_p.T228M|PCBP2_ENST00000546463.1_Missense_Mutation_p.T255M|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000552296.2_Missense_Mutation_p.T255M|PCBP2_ENST00000548933.1_Missense_Mutation_p.T228M|PCBP2_ENST00000549863.1_Missense_Mutation_p.T214M|PCBP2_ENST00000455667.3_Missense_Mutation_p.T224M|PCBP2_ENST00000447282.1_Missense_Mutation_p.T228M|PCBP2_ENST00000439930.3_Missense_Mutation_p.T259M|PCBP2_ENST00000541275.1_Missense_Mutation_p.T255M|PCBP2_ENST00000359462.5_Missense_Mutation_p.T259M|PCBP2_ENST00000437231.1_Missense_Mutation_p.T224M|PCBP2_ENST00000359282.5_Missense_Mutation_p.T224M	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	259					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						TTTCCCATGACGCATGGCAAC	0.488000													25	54					0	0	1	0	0
RGS7BP	401190	broad.mit.edu	37	5	63871674	63871674	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:63871674A>G	ENST00000334025.2	+	3	732	c.406A>G	c.(406-408)Acc>Gcc	p.T136A	RGS7BP_ENST00000508162.1_3'UTR	NM_001029875.1|NM_001271890.1|NM_001271891.1	NP_001025046.1|NP_001258819.1|NP_001258820.1	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding protein	136					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane				breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|stomach(1)	11		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		AGAAATGTATACCACAGAGAT	0.428000													31	50					0	0	1	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110035942	110035942	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:110035942C>T	ENST00000453089.2	+	5	2920	c.2039C>T	c.(2038-2040)cCg>cTg	p.P680L	ZC3H12C_ENST00000278590.3_Missense_Mutation_p.P711L|ZC3H12C_ENST00000528673.1_Missense_Mutation_p.P712L			Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	711							endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		CTGCACCTGCCGCACTCCGCT	0.587000													44	81					0	0	1	0	0
LYPD6	130574	broad.mit.edu	37	2	150325226	150325226	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:150325226C>A	ENST00000334166.4	+	4	542	c.285C>A	c.(283-285)cgC>cgA	p.R95R	LYPD6_ENST00000409381.1_Silent_p.R95R	NM_194317.3	NP_919298.1	Q86Y78	LYPD6_HUMAN	LY6/PLAUR domain containing 6	95	UPAR/Ly6.					extracellular region				large_intestine(1)|lung(4)	5				BRCA - Breast invasive adenocarcinoma(221;0.0667)		TCACCAAACGCTGTGTCCCAC	0.483000													33	74					6.97489e-18	7.68957e-18	1	1	0
MYO1F	4542	broad.mit.edu	37	19	8612935	8612935	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8612935G>A	ENST00000338257.8	-	12	1521	c.1254C>T	c.(1252-1254)acC>acT	p.T418T		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	418	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CGGCCTTCAGGGTAAGTTCGA	0.547000													38	54					0	0	1	0	0
MTHFSD	64779	broad.mit.edu	37	16	86585801	86585801	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:86585801C>T	ENST00000381214.5	-	3	239	c.221G>A	c.(220-222)cGc>cAc	p.R74H	MTHFSD_ENST00000322911.6_Intron|MTHFSD_ENST00000546093.1_5'UTR|MTHFSD_ENST00000543303.2_Missense_Mutation_p.R73H|MTHFSD_ENST00000568037.1_5'UTR|MTHFSD_ENST00000360900.6_Intron	NM_001159378.1	NP_001152850.1	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain containing	74					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding	p.R74H(1)		endometrium(1)|large_intestine(3)|lung(6)|skin(1)	11						GACGAAGAAGCGAGCACTTTT	0.498000													16	23					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78468006	78468006	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:78468006G>A	ENST00000278550.7	-	19	3062	c.2600C>T	c.(2599-2601)cCg>cTg	p.P867L		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		AAGGCACAGCGGGTTGATATG	0.547000													4	16					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12443156	12443156	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12443156C>A	ENST00000358136.3	+	58	11442	c.11312C>A	c.(11311-11313)cCt>cAt	p.P3771H	VPS13D_ENST00000496628.1_3'UTR|VPS13D_ENST00000356315.4_Missense_Mutation_p.P3746H	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3770					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AAAATGAGACCTGGTTCTGGA	0.423000													30	41					1.75199e-13	1.90424e-13	1	1	0
PARD3	56288	broad.mit.edu	37	10	34759156	34759156	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:34759156C>T	ENST00000374789.3	-	4	764	c.439G>A	c.(439-441)Gct>Act	p.A147T	PARD3_ENST00000374794.3_Missense_Mutation_p.A147T|PARD3_ENST00000350537.4_Missense_Mutation_p.A147T|PARD3_ENST00000374788.3_Missense_Mutation_p.A147T|PARD3_ENST00000374773.1_Missense_Mutation_p.A147T|PARD3_ENST00000545693.1_Missense_Mutation_p.A147T|PARD3_ENST00000374776.1_Missense_Mutation_p.A147T|PARD3_ENST00000346874.4_Missense_Mutation_p.A147T|PARD3_ENST00000374790.3_Missense_Mutation_p.A147T|PARD3_ENST00000545260.1_Missense_Mutation_p.A147T|PARD3_ENST00000340077.5_Missense_Mutation_p.A147T	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	147					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				CCAATTAGAGCTGGGTCACTA	0.423000													4	97					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275878	152275878	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:152275878C>T	ENST00000368799.1	-	3	11519	c.11484G>A	c.(11482-11484)tcG>tcA	p.S3828S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3828	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGTGACGCGACCCTGAGT	0.587000									Ichthyosis				105	155					0	0	1	0	0
WEE2	494551	broad.mit.edu	37	7	141427171	141427171	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:141427171G>A	ENST00000397541.2	+	10	1866	c.1460G>A	c.(1459-1461)cGg>cAg	p.R487Q	WEE2-AS1_ENST00000488785.1_RNA	NM_001105558.1	NP_001099028.1	P0C1S8	WEE2_HUMAN	WEE1 homolog 2 (S. pombe)	487					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31	Melanoma(164;0.0171)					ACAGTTCTCCGGCCTTCCCTG	0.473000													55	72					0	0	1	0	0
EXOC7	23265	broad.mit.edu	37	17	74087307	74087307	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74087307C>T	ENST00000607838.1	-	7	912	c.818G>A	c.(817-819)cGt>cAt	p.R273H	EXOC7_ENST00000335146.7_Missense_Mutation_p.R273H|EXOC7_ENST00000332065.5_Intron|EXOC7_ENST00000411744.2_Intron|EXOC7_ENST00000467929.2_Missense_Mutation_p.R232H|EXOC7_ENST00000405575.4_Missense_Mutation_p.R273H|EXOC7_ENST00000589210.1_Missense_Mutation_p.R273H	NM_001145297.2|NM_001145298.2|NM_001145299.2	NP_001138769.1|NP_001138770.1|NP_001138771.1	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7	273					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			CTGAGCCTTACGGATCGTCCC	0.537000													34	55					0	0	1	0	0
GREM2	64388	broad.mit.edu	37	1	240656719	240656719	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:240656719C>T	ENST00000318160.4	-	2	323	c.57G>A	c.(55-57)gcG>gcA	p.A19A		NM_022469.3	NP_071914.3	Q9H772	GREM2_HUMAN	gremlin 2, DAN family BMP antagonist	19					BMP signaling pathway	extracellular space	cytokine activity			endometrium(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	10		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			TCCGGGCTTCCGCCACCTTCA	0.617000													8	14					0	0	1	0	0
XPO6	23214	broad.mit.edu	37	16	28117489	28117489	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:28117489G>A	ENST00000304658.5	-	20	3159	c.2659C>T	c.(2659-2661)Cgg>Tgg	p.R887W	XPO6_ENST00000565698.1_Missense_Mutation_p.R873W	NM_015171.2	NP_055986.1	Q96QU8	XPO6_HUMAN	exportin 6	887					protein export from nucleus		protein binding|protein transporter activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25						TCCACCACCCGGCAGCCTGTG	0.597000													13	23					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	108518288	108518288	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:108518288C>T	ENST00000375915.2	-	1	795	c.657G>A	c.(655-657)tcG>tcA	p.S219S		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	219						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						GGTAAAAATCCGACAAGTTCC	0.577000													28	39					0	0	1	0	0
BUB1B	701	broad.mit.edu	37	15	40512938	40512938	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40512938C>A	ENST00000287598.6	+	23	3326	c.3131C>A	c.(3130-3132)cCt>cAt	p.P1044H	BUB1B_ENST00000412359.3_Missense_Mutation_p.P1058H|RP11-133K1.2_ENST00000558658.1_Intron|PAK6_ENST00000441369.1_Intron|PAK6_ENST00000453867.1_Intron	NM_001211.5	NP_001202.4	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	1044	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TTAACTAGTCCTGGGGCTTTG	0.453000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				19	72					5.35267e-07	5.59292e-07	1	1	0
RP11-85G18.6	0	broad.mit.edu	37	10	27538280	27538280	+	RNA	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:27538280A>G	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							GCTGAGCCCGACCCTTGTCTG	0.512000													52	80					0	0	1	0	0
CXXC1	30827	broad.mit.edu	37	18	47812603	47812603	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:47812603C>T	ENST00000285106.6	-	4	962	c.248G>A	c.(247-249)cGc>cAc	p.R83H	CXXC1_ENST00000587396.1_5'UTR|CXXC1_ENST00000589940.1_Missense_Mutation_p.R83H|CXXC1_ENST00000412036.2_Missense_Mutation_p.R83H	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	83					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						GTGCCGATAGCGAATCTCTAG	0.577000													41	64					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143081568	143081568	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:143081568C>T	ENST00000367603.2	-	9	6599	c.5857G>A	c.(5857-5859)Gta>Ata	p.V1953I	HIVEP2_ENST00000367604.1_Missense_Mutation_p.V1953I|HIVEP2_ENST00000012134.2_Missense_Mutation_p.V1953I	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1953					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CCGTGGGGTACGGCGCCAACA	0.478000													13	38					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39525700	39525700	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:39525700A>G	ENST00000265707.5	+	14	1555	c.1510A>G	c.(1510-1512)Aag>Gag	p.K504E	ADAM18_ENST00000379866.1_Missense_Mutation_p.K480E|ADAM18_ENST00000541111.1_5'UTR	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	504	Cys-rich.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CCAGTGTGCCAAGATATTTGG	0.383000													44	79					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39986551	39986551	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:39986551C>T	ENST00000373257.3	+	17	2160	c.2069C>T	c.(2068-2070)gCg>gTg	p.A690V		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	690	C-LIP.				fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				TACTGCTCGGCGCGGGCCATT	0.617000													21	24					0	0	1	0	0
ZNF302	55900	broad.mit.edu	37	19	35175305	35175305	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35175305C>T	ENST00000505242.1	+	5	857	c.363C>T	c.(361-363)tgC>tgT	p.C121C	ZNF302_ENST00000509528.1_3'UTR|ZNF302_ENST00000423823.2_Silent_p.C121C|ZNF302_ENST00000505365.2_3'UTR|ZNF302_ENST00000507959.1_3'UTR|ZNF302_ENST00000457781.2_Silent_p.C121C|ZNF302_ENST00000446502.2_Silent_p.C165C			Q9NR11	ZN302_HUMAN	zinc finger protein 302	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ATACAGAATGCGACACATTTA	0.303000													10	12					0	0	1	0	0
PDS5B	23047	broad.mit.edu	37	13	33261280	33261280	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:33261280C>T	ENST00000315596.10	+	12	1399	c.1213C>T	c.(1213-1215)Cgc>Tgc	p.R405C		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	405					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding	p.R405C(1)		NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		GTGGAGAGTACGCAAAGAAGC	0.333000													32	122					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35703882	35703882	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35703882C>T	ENST00000314888.9	-	47	6600	c.6247G>A	c.(6247-6249)Gca>Aca	p.A2083T	TLN1_ENST00000540444.1_Missense_Mutation_p.A1977T|TLN1_ENST00000464379.1_5'UTR	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	2083					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCTTTCACTGCGTTGATTAGT	0.537000													8	67					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19348668	19348668	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:19348668C>T	ENST00000261537.6	+	3	750	c.486C>T	c.(484-486)gaC>gaT	p.D162D	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	162	MIB/HERC2 2.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			GAGGAGTGGACTGGCAGTGGG	0.413000													4	10					0	0	1	0	0
ITGA10	8515	broad.mit.edu	37	1	145533526	145533526	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145533526C>A	ENST00000369304.3	+	12	1584	c.1409C>A	c.(1408-1410)gCt>gAt	p.A470D	ITGA10_ENST00000538811.1_Missense_Mutation_p.A339D|ITGA10_ENST00000539363.1_Missense_Mutation_p.A327D	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	470					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAAGATGGGGCTGTGAGGGTT	0.587000													6	35					2.7689e-08	2.91998e-08	1	1	0
KIAA1211L	343990	broad.mit.edu	37	2	99454682	99454682	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:99454682A>G	ENST00000397899.2	-	3	470	c.139T>C	c.(139-141)Tcg>Ccg	p.S47P	KIAA1211L_ENST00000462314.1_5'UTR	NM_207362.2	NP_997245.2			KIAA1211-like																		CCTGTGGACGACGGCGATTCT	0.403000													6	33					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25259028	25259028	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:25259028G>A	ENST00000216962.4	+	8	1039	c.929G>A	c.(928-930)cGc>cAc	p.R310H		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	310					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	GACATCATCCGCCGCTTCAAG	0.607000													9	22					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	7026873	7026873	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:7026873G>A	ENST00000409757.4	+	13	2024	c.1900G>A	c.(1900-1902)Gac>Aac	p.D634N	TBC1D14_ENST00000451522.2_Missense_Mutation_p.D354N|TBC1D14_ENST00000410031.1_Missense_Mutation_p.D406N|TBC1D14_ENST00000446947.2_Missense_Mutation_p.D281N|TBC1D14_ENST00000448507.1_Missense_Mutation_p.D634N	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	634						intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						GACCAAGATGGACTTCATTCA	0.602000													35	41					0	0	1	0	0
LGR4	55366	broad.mit.edu	37	11	27390171	27390171	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:27390171T>C	ENST00000379214.4	-	18	2542	c.2099A>G	c.(2098-2100)gAa>gGa	p.E700G	LGR4_ENST00000389858.4_Missense_Mutation_p.E676G	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	700						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						TGATGGCGTTTCACCTGTAGG	0.408000													30	40					0	0	1	0	0
SRRT	51593	broad.mit.edu	37	7	100483353	100483353	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100483353T>C	ENST00000388793.4	+	11	1566	c.1346T>C	c.(1345-1347)gTg>gCg	p.V449A	SRRT_ENST00000347433.4_Missense_Mutation_p.V450A|SRRT_ENST00000457580.2_Missense_Mutation_p.V450A|SRRT_ENST00000432932.1_Missense_Mutation_p.V449A	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	450					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						TTTATGCGGGTGGCGCTCTCA	0.547000													6	10					0	0	1	0	0
HOOK2	29911	broad.mit.edu	37	19	12875650	12875650	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12875650C>T	ENST00000264827.5	-	19	1969	c.1799G>A	c.(1798-1800)cGc>cAc	p.R600H	HOOK2_ENST00000397668.3_Missense_Mutation_p.R602H	NM_001100176.1	NP_001093646.1	Q96ED9	HOOK2_HUMAN	hook microtubule-tethering protein 2	602	Required for localization to the centrosome and induction of aggresome formation.|Sufficient for interaction with CEP110.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(5)|skin(1)	20						GTCCACGTAGCGGCGGTATCG	0.607000											OREG0025273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	56					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98565172	98565172	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:98565172C>T	ENST00000359863.4	+	50	7551	c.7342C>T	c.(7342-7344)Cgc>Tgc	p.R2448C	TRRAP_ENST00000355540.3_Missense_Mutation_p.R2430C|TRRAP_ENST00000446306.3_Missense_Mutation_p.R2430C	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2448					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CTCTGGGCTGCGCTGTGCCCA	0.542000													27	44					0	0	1	0	0
NANS	54187	broad.mit.edu	37	9	100823218	100823218	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:100823218G>T	ENST00000210444.5	+	2	357	c.287G>T	c.(286-288)aGg>aTg	p.R96M		NM_018946.3	NP_061819.2	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid synthase	96					lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	11		Acute lymphoblastic leukemia(62;0.0559)				GACCAGTACAGGGAGCTGCAG	0.547000													25	43					1.37878e-21	1.53209e-21	1	1	0
AQP12A	375318	broad.mit.edu	37	2	241631739	241631739	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:241631739G>A	ENST00000429564.1	+	2	471	c.408G>A	c.(406-408)gaG>gaA	p.E136E	AQP12A_ENST00000337801.4_Silent_p.E124E			Q8IXF9	AQ12A_HUMAN	aquaporin 12A	124						integral to membrane	transporter activity			endometrium(2)|kidney(3)|large_intestine(2)|lung(7)	14		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		GGGCCTGGGAGCTCAGTGACC	0.706000													10	6					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45000983	45000983	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:45000983T>C	ENST00000429094.2	-	15	2136	c.1632A>G	c.(1630-1632)ccA>ccG	p.P544P	NELL2_ENST00000452445.2_Silent_p.P544P|NELL2_ENST00000437801.2_Silent_p.P594P|NELL2_ENST00000395487.2_Silent_p.P543P|NELL2_ENST00000333837.4_Silent_p.P567P|NELL2_ENST00000549027.1_Silent_p.P543P|NELL2_ENST00000551601.1_Silent_p.P543P	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	544	EGF-like 4.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TGAAGCCTTGTGGGCAGGCAC	0.393000													16	22					0	0	1	0	0
KRT6B	3854	broad.mit.edu	37	12	52844401	52844401	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:52844401G>A	ENST00000252252.3	-	2	591	c.544C>T	c.(544-546)Cgg>Tgg	p.R182W		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	182	Coil 1A.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton	p.R182W(1)		NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		TCTAGGAACCGCACCTGGAGG	0.557000													9	56					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62417235	62417235	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62417235G>T	ENST00000330574.2	-	2	369	c.317C>A	c.(316-318)cCt>cAt	p.P106H	RP11-831H9.11_ENST00000528405.1_3'UTR	NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	106					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						AGAGGGTGGAGGTGGACGGAG	0.597000													35	53					1.26612e-14	1.38261e-14	1	1	0
BCKDK	10295	broad.mit.edu	37	16	31122645	31122645	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31122645C>T	ENST00000394951.1	+	11	1493	c.870C>T	c.(868-870)gaC>gaT	p.D290D	BCKDK_ENST00000394950.3_Silent_p.D290D|BCKDK_ENST00000287507.3_Intron|BCKDK_ENST00000219794.6_Silent_p.D290D			O14874	BCKD_HUMAN	branched chain ketoacid dehydrogenase kinase	290	Histidine kinase.				branched chain family amino acid catabolic process|peptidyl-histidine phosphorylation	mitochondrial alpha-ketoglutarate dehydrogenase complex	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity|ATP binding|protein binding|protein serine/threonine kinase activity|two-component sensor activity			breast(1)|stomach(1)	2						GTCACCTAGACACTCCCTACA	0.547000													16	21					0	0	1	0	0
POU6F1	5463	broad.mit.edu	37	12	51584091	51584091	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:51584091A>T	ENST00000389243.4	-	11	1784	c.845T>A	c.(844-846)tTc>tAc	p.F282Y	POU6F1_ENST00000333640.10_Missense_Mutation_p.F282Y|POU6F1_ENST00000550824.1_Missense_Mutation_p.F282Y			Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	282					brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	11						CCGATTGCAGAACCAGACCCG	0.537000													26	45					0	0	1	0	0
UBP1	7342	broad.mit.edu	37	3	33450268	33450268	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:33450268C>T	ENST00000283629.3	-	8	1370	c.841G>A	c.(841-843)Gaa>Aaa	p.E281K	UBP1_ENST00000283628.5_Missense_Mutation_p.E281K|UBP1_ENST00000447368.2_Intron	NM_001128161.1|NM_014517.4	NP_001121633.1|NP_055332.3	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a)	281					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|urinary_tract(2)	23						ACTGCATCTTCAATTATAGGC	0.438000													31	67					0	0	1	0	0
PDLIM7	9260	broad.mit.edu	37	5	176911074	176911074	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176911074G>A	ENST00000355841.2	-	11	1234	c.1168C>T	c.(1168-1170)Cga>Tga	p.R390*	PDLIM7_ENST00000356618.4_3'UTR|PDLIM7_ENST00000505746.1_5'UTR|PDLIM7_ENST00000359895.2_Nonsense_Mutation_p.R356*	NM_005451.3	NP_005442.2	Q9NR12	PDLI7_HUMAN	PDZ and LIM domain 7 (enigma)	390	LIM zinc-binding 2.				cell differentiation|multicellular organismal development|ossification|receptor-mediated endocytosis	cytoplasm|focal adhesion	protein binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	10	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGGTACCTCGCTCGCAATAG	0.587000													11	20					0	0	1	0	0
SF3B4	10262	broad.mit.edu	37	1	149898267	149898267	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:149898267C>T	ENST00000271628.8	-	3	1291		c.e3+1			NM_005850.4	NP_005841.1	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4, 49kDa							nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			endometrium(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)	17	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			AAAAGCTTTACCTGGTGGAGG	0.512000													18	14					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183772516	183772516	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:183772516C>T	ENST00000318351.1	+	2	109	c.75C>T	c.(73-75)ggC>ggT	p.G25G		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	25						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TAGGAAGAGGCGACGCTTTTA	0.512000													26	40					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826457	43826457	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:43826457G>A	ENST00000389420.3	-	20	2877	c.2878C>T	c.(2878-2880)Cta>Tta	p.L960L	ADAMTS20_ENST00000395541.2_Silent_p.L114L|ADAMTS20_ENST00000553158.1_Silent_p.L960L	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	960	TSP type-1 3.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCATGGCATAGTTCTTGGGTA	0.398000													20	30					0	0	1	0	0
RASA2	5922	broad.mit.edu	37	3	141290329	141290329	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:141290329C>T	ENST00000286364.3	+	11	1137	c.1102C>T	c.(1102-1104)Ctg>Ttg	p.L368L	RASA2_ENST00000452898.1_Silent_p.L368L			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	368	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						TGTACGACTGCTGCTGCACCA	0.368000													41	75					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35091339	35091339	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35091339G>A	ENST00000378617.3	-	7	2939	c.2545C>T	c.(2545-2547)Ctg>Ttg	p.L849L	PIGO_ENST00000361778.2_Intron|PIGO_ENST00000298004.5_Intron|PIGO_ENST00000341666.3_Silent_p.L849L	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	849					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCATGCAACAGCAGAAGTGGG	0.562000													4	8					0	0	1	0	0
GAPDH	2597	broad.mit.edu	37	12	6645760	6645760	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6645760G>A	ENST00000229239.5	+	3	795		c.e3+1		GAPDH_ENST00000396861.1_Splice_Site|GAPDH_ENST00000396858.1_Splice_Site|GAPDH_ENST00000396856.1_Splice_Site|GAPDH_ENST00000396859.1_Splice_Site	NM_002046.4	NP_002037.2	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase						gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|lung(4)	7					NADH(DB00157)	CAACTACATGGTGAGTGCTAC	0.522000													40	59					0	0	1	0	0
RUVBL2	10856	broad.mit.edu	37	19	49510398	49510398	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49510398G>A	ENST00000413176.2	+	5	1402	c.254G>A	c.(253-255)cGc>cAc	p.R85H	RUVBL2_ENST00000595090.1_Missense_Mutation_p.R130H|RUVBL2_ENST00000601968.1_Missense_Mutation_p.R85H			Q9Y230	RUVB2_HUMAN	RuvB-like AAA ATPase 2	130					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding			large_intestine(1)|upper_aerodigestive_tract(1)	2		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		ATCGGCGTTCGCATCAAGTAA	0.657000													22	27					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	825228	825228	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:825228C>T	ENST00000297440.6	+	13	2526	c.2506C>T	c.(2506-2508)Cgc>Tgc	p.R836C	HEATR2_ENST00000403952.3_Missense_Mutation_p.R261C|HEATR2_ENST00000313147.5_Intron	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	836							protein binding	p.R836S(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		CCACAAGCACCGCTCGGCCAC	0.607000													31	46					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13743457	13743457	+	Silent	SNP	C	C	T	rs150190257	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:13743457C>T	ENST00000357447.2	-	14	1226	c.858G>A	c.(856-858)acG>acA	p.T286T	FRMD4A_ENST00000358621.4_Silent_p.T271T|FRMD4A_ENST00000342409.2_Silent_p.T302T|FRMD4A_ENST00000378503.1_Silent_p.T286T|FRMD4A_ENST00000492155.1_5'UTR	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	286	FERM.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						TGTGCCCAAACGTCCTCCTTG	0.498000													21	39					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43010619	43010619	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43010619G>A	ENST00000535468.1	-	19	3904	c.3818C>T	c.(3817-3819)cCt>cTt	p.P1273L	CUL7_ENST00000265348.3_Missense_Mutation_p.P1189L	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	1189					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GGCTGCCCGAGGCCCAAACAG	0.527000													4	24					0	0	1	0	0
RPL10L	140801	broad.mit.edu	37	14	47120929	47120929	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:47120929C>T	ENST00000298283.3	-	1	99	c.11G>A	c.(10-12)cGt>cAt	p.R4H		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	4					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						GCGAGCTGGACGGCGCCCCAT	0.557000													23	50					0	0	1	0	0
PKNOX2	63876	broad.mit.edu	37	11	125221244	125221244	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:125221244G>A	ENST00000298282.9	+	4	314	c.43G>A	c.(43-45)Gcc>Acc	p.A15T	PKNOX2_ENST00000542175.1_5'UTR|PKNOX2_ENST00000530517.1_Intron	NM_022062.2	NP_071345.2	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	15						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(14)|ovary(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	29		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		GACGATGATGGCCACGCAGAA	0.647000													3	5					0	0	1	0	0
CCDC42	146849	broad.mit.edu	37	17	8647479	8647479	+	Missense_Mutation	SNP	G	G	A	rs143164438		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8647479G>A	ENST00000293845.3	-	2	333	c.107C>T	c.(106-108)gCg>gTg	p.A36V	CCDC42_ENST00000539522.2_Missense_Mutation_p.A36V	NM_144681.2	NP_653282.2	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42	36										kidney(1)|large_intestine(4)|lung(3)|ovary(1)	9						GGACTCCGACGCCCCCTCAAC	0.547000													19	44					0	0	1	0	0
PCDHB15	0	broad.mit.edu	37	5	140627234	140627234	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140627234G>A	ENST00000231173.3	+	1	2088	c.2088G>A	c.(2086-2088)tcG>tcA	p.S696S		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		696					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATTGGCCTCGGTGTCTTCGC	0.677000													49	59					0	0	1	0	0
WDR46	9277	broad.mit.edu	37	6	33248658	33248658	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33248658C>T	ENST00000374617.4	-	11	1578	c.1222G>A	c.(1222-1224)Gcc>Acc	p.A408T	B3GALT4_ENST00000606990.1_Intron	NM_001164267.1|NM_005452.5	NP_001157739.1|NP_005443.3	O15213	WDR46_HUMAN	WD repeat domain 46	408										NS(1)|breast(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	20						TGGGAGAAGGCCAGGTGCCCT	0.637000													13	36					0	0	1	0	0
APOC1	341	broad.mit.edu	37	19	45419502	45419502	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45419502G>T	ENST00000588750.1	+	4	439	c.114G>T	c.(112-114)aaG>aaT	p.K38N	APOC1_ENST00000586638.1_Missense_Mutation_p.K38N|APOC1_ENST00000252491.4_Missense_Mutation_p.K38N|APOC1_ENST00000588802.1_Missense_Mutation_p.K38N|APOC1_ENST00000592885.1_Missense_Mutation_p.K38N|APOC1_ENST00000589781.1_Intron			P02654	APOC1_HUMAN	apolipoprotein C-I	38					cholesterol efflux|chylomicron remnant clearance|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol transport|negative regulation of fatty acid biosynthetic process|negative regulation of lipoprotein lipase activity|negative regulation of phosphatidylcholine catabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of very-low-density lipoprotein particle clearance|phospholipid efflux|positive regulation of cholesterol esterification|very-low-density lipoprotein particle assembly|very-low-density lipoprotein particle clearance	chylomicron|endoplasmic reticulum|high-density lipoprotein particle|very-low-density lipoprotein particle	fatty acid binding|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipase inhibitor activity			cervix(1)|large_intestine(1)|lung(2)	4	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)		ATAAGCTGAAGGAGTTTGGAA	0.532000													15	29					3.8784e-16	4.25337e-16	1	1	0
HELB	92797	broad.mit.edu	37	12	66717800	66717800	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:66717800A>G	ENST00000247815.4	+	10	2394	c.2335A>G	c.(2335-2337)Aaa>Gaa	p.K779E		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	779					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		AATTGGTGATAAAATTTGTTG	0.353000													24	52					0	0	1	0	0
PPP1R11	6992	broad.mit.edu	37	6	30036976	30036976	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30036976C>T	ENST00000376772.3	+	3	597	c.274C>T	c.(274-276)Cgt>Tgt	p.R92C	PPP1R11_ENST00000376765.2_Missense_Mutation_p.R40C|PPP1R11_ENST00000376763.1_Missense_Mutation_p.R40C|PPP1R11_ENST00000376758.1_Missense_Mutation_p.R40C|PPP1R11_ENST00000376769.2_Missense_Mutation_p.R40C|PPP1R11_ENST00000376773.1_Missense_Mutation_p.R40C	NM_021959.2	NP_068778.1	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 11	92						soluble fraction	protein binding|protein phosphatase inhibitor activity			lung(2)|ovary(1)|prostate(1)|skin(2)	6						ACACTGTGTACGTGGCCACCG	0.607000													15	28					0	0	1	0	0
BTG3	10950	broad.mit.edu	37	21	18966550	18966550	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:18966550G>T	ENST00000339775.6	-	6	905	c.752C>A	c.(751-753)cCt>cAt	p.P251H	BTG3_ENST00000348354.6_Missense_Mutation_p.P207H	NM_001130914.1	NP_001124386.1	Q14201	BTG3_HUMAN	BTG family, member 3	207					negative regulation of cell proliferation|negative regulation of mitotic cell cycle	cytoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)	8				Epithelial(23;0.000283)|all cancers(11;0.0012)|Lung(58;0.0191)|OV - Ovarian serous cystadenocarcinoma(11;0.0206)|COAD - Colon adenocarcinoma(22;0.0315)|LUSC - Lung squamous cell carcinoma(23;0.0703)|Colorectal(24;0.0971)		TGGAACAGGAGGAGGATAGTG	0.448000													12	25					0.000219431	0.000224427	1	1	0
OSBP2	23762	broad.mit.edu	37	22	31266435	31266435	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31266435C>T	ENST00000332585.6	+	3	977	c.873C>T	c.(871-873)gaC>gaT	p.D291D	OSBP2_ENST00000382310.3_Silent_p.D291D|OSBP2_ENST00000407373.1_Silent_p.D118D|OSBP2_ENST00000401475.1_5'UTR|OSBP2_ENST00000403222.3_Silent_p.D126D|OSBP2_ENST00000446658.2_Silent_p.D291D|OSBP2_ENST00000437268.2_Silent_p.D33D	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	291					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						GGGACGACGACGAGGCTACCA	0.557000													7	18					0	0	1	0	0
AVPR1B	553	broad.mit.edu	37	1	206225087	206225087	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:206225087C>T	ENST00000367126.4	+	1	1112	c.647C>T	c.(646-648)aCg>aTg	p.T216M		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	216					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	ACCATGCTCACGGCCTGCTAC	0.612000													37	36					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028326	37028326	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:37028326G>A	ENST00000358047.3	+	1	1895	c.1843G>A	c.(1843-1845)Gta>Ata	p.V615I		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	615										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGAGACTCGCGTATCTCATCT	0.652000													58	6					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45427302	45427302	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:45427302G>A	ENST00000321429.4	+	6	715	c.307_splice	c.e6-1	p.G103_splice	DUOX1_ENST00000389037.3_Splice_Site_p.G103_splice	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	103	Peroxidase-like; mediates peroxidase activity.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CTGCCCGCAGGCTATCACGTG	0.602000													14	18					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82879713	82879713	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:82879713G>A	ENST00000298281.4	+	8	2788	c.2336G>A	c.(2335-2337)cGa>cAa	p.R779Q		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	779	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						TTAAGCCCTCGAATTGATGGA	0.502000													16	28					0	0	1	0	0
CELA1	1990	broad.mit.edu	37	12	51735033	51735033	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:51735033G>A	ENST00000293636.1	-	5	498	c.458C>T	c.(457-459)aCc>aTc	p.T153I		NM_001971.5	NP_001962.3	Q9UNI1	CELA1_HUMAN	chymotrypsin-like elastase family, member 1	153	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15						CTTACTCTTGGTCTTGCCCCA	0.522000											OREG0021819	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	29					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38952304	38952304	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:38952304G>A	ENST00000357387.3	-	30	3151	c.3121C>T	c.(3121-3123)Cca>Tca	p.P1041S	RICTOR_ENST00000296782.5_Missense_Mutation_p.P1041S	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1041	Ser-rich.				actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					TCACTCGATGGCACAGATTCA	0.333000													4	42					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	21592318	21592318	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:21592318G>T	ENST00000298925.5	+	19	2226	c.2073G>T	c.(2071-2073)aaG>aaT	p.K691N	NELL1_ENST00000529218.1_3'UTR|NELL1_ENST00000325319.5_Missense_Mutation_p.K606N|NELL1_ENST00000532434.1_Missense_Mutation_p.K616N|NELL1_ENST00000357134.5_Missense_Mutation_p.K663N			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	663					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						AGGATGGCAAGATATTCTGCC	0.433000													22	26					9.86323e-18	1.08645e-17	1	1	0
LMAN1L	79748	broad.mit.edu	37	15	75117858	75117858	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75117858G>A	ENST00000309664.5	+	14	1632	c.1493G>A	c.(1492-1494)gGc>gAc	p.G498D	RP11-414J4.2_ENST00000564823.1_RNA|LMAN1L_ENST00000379709.3_Missense_Mutation_p.G486D	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	498						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CTGTCCACAGGCAGCCTTCCT	0.587000													45	107					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112622183	112622183	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112622183C>T	ENST00000550722.1	-	61	10544	c.10149G>A	c.(10147-10149)gcG>gcA	p.A3383A	HECTD4_ENST00000377560.5_Silent_p.A3357A|HECTD4_ENST00000430131.2_Silent_p.A3107A	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GGCTGGACACCGCGTGGGGCT	0.687000													5	8					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333465	70333465	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:70333465C>T	ENST00000338508.4	-	32	2935	c.2936G>A	c.(2935-2937)cGc>cAc	p.R979H	SHANK2_ENST00000423696.2_Missense_Mutation_p.R599H|SHANK2_ENST00000449833.2_Missense_Mutation_p.R383H|SHANK2_ENST00000409161.1_Missense_Mutation_p.R382H			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	599					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TCTCTTGTTGCGGAAGTTGGC	0.597000													42	55					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92472518	92472518	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:92472518C>T	ENST00000267622.4	-	11	2175	c.1802G>A	c.(1801-1803)aGc>aAc	p.S601N		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	601					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		CTTCTGGATGCTTACATTACT	0.338000			T	PDGFRB	AML								14	28					0	0	1	0	0
DHX35	60625	broad.mit.edu	37	20	37662960	37662960	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:37662960G>A	ENST00000252011.3	+	21	2100	c.2067_splice	c.e21+1	p.T689_splice	DHX35_ENST00000373323.4_Splice_Site_p.T658_splice|DHX35_ENST00000373325.2_Splice_Site_p.T665_splice	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	689						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				AACAAGGAACGGTAGGAATGA	0.453000													4	22					0	0	1	0	0
DENND6A	201627	broad.mit.edu	37	3	57631400	57631400	+	Missense_Mutation	SNP	C	C	T	rs150271072	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:57631400C>T	ENST00000311128.5	-	11	1095	c.1025G>A	c.(1024-1026)cGt>cAt	p.R342H	RP11-755B10.2_ENST00000470427.1_RNA	NM_152678.2	NP_689891.1			DENN/MADD domain containing 6A																		AGCTTGGGTACGGGTAGTATA	0.333000													25	31					0	0	1	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77040182	77040182	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:77040182G>A	ENST00000339142.2	+	3	687	c.132G>A	c.(130-132)ccG>ccA	p.P44P	C1QTNF1_ENST00000580474.1_Silent_p.P44P|C1QTNF1_ENST00000583904.1_Silent_p.P44P|C1QTNF1_ENST00000581774.1_Silent_p.P44P|C1QTNF1_ENST00000580454.1_Silent_p.P44P|C1QTNF1_ENST00000579760.1_Silent_p.P44P|C1QTNF1_ENST00000578229.1_5'UTR|C1QTNF1_ENST00000392445.2_Silent_p.P44P|C1QTNF1_ENST00000354124.3_Silent_p.P54P|C1QTNF1_ENST00000311661.4_Intron	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	44						collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			AGGAGCTGCCGTCGCCTCCGG	0.677000													9	10					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73071497	73071497	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:73071497G>A	ENST00000263674.3	+	11	4689	c.4339G>A	c.(4339-4341)Gac>Aac	p.D1447N		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1447					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						CGAGGGCACCGACTCCTACAT	0.607000													44	58					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158617376	158617376	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158617376C>A	ENST00000368148.3	-	27	4029	c.3849G>T	c.(3847-3849)gaG>gaT	p.E1283D	SPTA1_ENST00000368147.3_Missense_Mutation_p.E1283D	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1283					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CATTTAGGCTCTCCTTACGAT	0.542000													19	39					1.33834e-09	1.42249e-09	1	1	0
IGSF22	283284	broad.mit.edu	37	11	18739554	18739554	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18739554G>A	ENST00000513874.1	-	9	1036	c.897C>T	c.(895-897)aaC>aaT	p.N299N	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	299	Ig-like 2.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						TCATGTTCACGTTGCTAATAA	0.552000													31	36					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85731295	85731295	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:85731295C>T	ENST00000322366.6	-	14	2497	c.2090G>A	c.(2089-2091)cGc>cAc	p.R697H	WDFY3_ENST00000295888.4_Missense_Mutation_p.R697H|WDFY3-AS1_ENST00000510449.1_RNA			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	697						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TGGCTCATAGCGCATTGCTGC	0.448000													16	44					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121652880	121652880	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:121652880G>A	ENST00000393386.2	+	12	4191	c.3780G>A	c.(3778-3780)ttG>ttA	p.L1260L	PTPRZ1_ENST00000483028.1_3'UTR|PTPRZ1_ENST00000449182.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1260					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						TTCAAGGTTTGACCATTTCCT	0.393000													30	60					0	0	1	0	0
FSTL3	10272	broad.mit.edu	37	19	681555	681555	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:681555G>A	ENST00000166139.4	+	4	760	c.728G>A	c.(727-729)tGc>tAc	p.C243Y	FSTL3_ENST00000592947.1_3'UTR	NM_005860.2	NP_005851.1	O95633	FSTL3_HUMAN	follistatin-like 3 (secreted glycoprotein)	243	Kazal-like 2.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding						all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGGCAGCTGCGCAGGTGCA	0.687000			T	CCND1	B-CLL								5	17					0	0	1	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123234070	123234070	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:123234070C>T	ENST00000349780.4	-	16	1993	c.1814G>A	c.(1813-1815)cGg>cAg	p.R605Q	CDK5RAP2_ENST00000360190.4_Missense_Mutation_p.R605Q|CDK5RAP2_ENST00000359309.3_Missense_Mutation_p.R605Q|CDK5RAP2_ENST00000360822.3_Missense_Mutation_p.R605Q	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	605					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						caaggtcttccgcaaattctg	0.463000													21	20					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157469870	157469870	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:157469870C>T	ENST00000346085.5	+	9	2665	c.2664C>T	c.(2662-2664)agC>agT	p.S888S	ARID1B_ENST00000367148.1_Silent_p.S875S|ARID1B_ENST00000350026.5_Silent_p.S875S|ARID1B_ENST00000275248.4_Silent_p.S817S	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	875					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		AAGGGCCAAGCCAGCCATGTG	0.592000													47	43					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126049557	126049557	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:126049557G>A	ENST00000318410.7	-	26	3452	c.3103C>T	c.(3103-3105)Cgc>Tgc	p.R1035C	KIAA0196_ENST00000517845.1_Missense_Mutation_p.R887C	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	1035					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TAGGGTAAGCGCTTTGTTGTT	0.313000													40	82					0	0	1	0	0
C18orf8	29919	broad.mit.edu	37	18	21095841	21095841	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:21095841C>A	ENST00000269221.3	+	6	540	c.430C>A	c.(430-432)Ctg>Atg	p.L144M	C18orf8_ENST00000590868.1_Missense_Mutation_p.L96M	NM_013326.3	NP_037458.3	Q96DM3	MIC1_HUMAN	chromosome 18 open reading frame 8	144										endometrium(9)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	21	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GAAACGGAGTCTGAAACTCTT	0.468000											OREG0024894	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	155					0.000602214	0.000612743	1	1	0
SPATA31E1	286234	broad.mit.edu	37	9	90500610	90500610	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:90500610T>C	ENST00000325643.5	+	4	1274	c.1208T>C	c.(1207-1209)cTa>cCa	p.L403P		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		ATCACGACCCTAAATCCCTTC	0.562000													15	31					0	0	1	0	0
VEZF1	7716	broad.mit.edu	37	17	56060232	56060232	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56060232C>T	ENST00000584396.1	-	2	617	c.529G>A	c.(529-531)Gtg>Atg	p.V177M	VEZF1_ENST00000581208.1_Missense_Mutation_p.V186M			Q14119	VEZF1_HUMAN	vascular endothelial zinc finger 1	186					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|lung(5)|ovary(1)	10						AGATGGTACACATCTCGGAAG	0.488000													15	19					0	0	1	0	0
HMMR	3161	broad.mit.edu	37	5	162910328	162910328	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:162910328G>A	ENST00000416990.2	+	15	1892	c.1395G>A	c.(1393-1395)tgG>tgA	p.W465*	RP11-80G7.1_ENST00000521666.1_RNA|HMMR_ENST00000432118.2_Nonsense_Mutation_p.W493*|HMMR_ENST00000353866.3_Nonsense_Mutation_p.W564*|HMMR_ENST00000393915.4_Nonsense_Mutation_p.W580*|HMMR_ENST00000358715.3_Nonsense_Mutation_p.W579*|RP11-80G7.1_ENST00000514724.2_RNA			O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor (RHAMM)	579						cell surface|cytoplasm	hyaluronic acid binding			cervix(1)|kidney(3)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	23	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		TTAACAAGTGGCGTCTCCTCT	0.294000													8	49					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31534279	31534279	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31534279C>T	ENST00000215885.3	-	3	1017	c.765G>A	c.(763-765)gcG>gcA	p.A255A		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	255	Phospholipase A2-like.				cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						ACCAGTACCACGCCACACACG	0.617000													6	13					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53611696	53611696	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53611696A>G	ENST00000455735.2	-	7	2066	c.1746T>C	c.(1744-1746)agT>agC	p.S582S	ZNF415_ENST00000243643.4_Silent_p.S534S|ZNF415_ENST00000595193.1_3'UTR|ZNF415_ENST00000597748.1_3'UTR|ZNF415_ENST00000601493.1_Silent_p.S304S|ZNF415_ENST00000597503.1_3'UTR|ZNF415_ENST00000594011.1_3'UTR|ZNF415_ENST00000500065.4_Silent_p.S534S|ZNF415_ENST00000448501.1_Silent_p.S582S|ZNF415_ENST00000440291.1_Silent_p.S521S|ZNF415_ENST00000421033.1_Silent_p.S546S			Q09FC8	ZN415_HUMAN	zinc finger protein 415	582					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		TTGGGCGCACACTAAAGGACT	0.388000													53	116					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114182104	114182104	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:114182104G>A	ENST00000393081.1	+	17	1805	c.1498G>A	c.(1498-1500)Gtg>Atg	p.V500M	ACSL5_ENST00000354655.4_Missense_Mutation_p.V500M|ACSL5_ENST00000433418.1_Missense_Mutation_p.V500M|ACSL5_ENST00000354273.4_Missense_Mutation_p.V500M|ACSL5_ENST00000369410.3_Missense_Mutation_p.V282M|ACSL5_ENST00000356116.1_Missense_Mutation_p.V556M	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	500					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		GGGTACAAACGTGTTCAAAGG	0.547000													21	23					0	0	1	0	0
PIAS4	51588	broad.mit.edu	37	19	4037780	4037780	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4037780G>T	ENST00000262971.2	+	11	1555	c.1440G>T	c.(1438-1440)gaG>gaT	p.E480D		NM_015897.2	NP_056981.2	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	480	Asp/Glu-rich (acidic).				positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(3)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		aggatgaggaggaggaggaag	0.706000													3	7					1	1	1	1	0
STX11	8676	broad.mit.edu	37	6	144508076	144508076	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:144508076G>A	ENST00000367568.4	+	2	495	c.312G>A	c.(310-312)ctG>ctA	p.L104L		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	104				KL -> NV (in Ref. 1; AAD02107).	cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		ACTGCAAGCTGCGCGCCATGA	0.677000									Familial Hemophagocytic Lymphohistiocytosis				8	13					0	0	1	0	0
COPRS	55352	broad.mit.edu	37	17	30179888	30179888	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:30179888C>T	ENST00000378634.2	-	3	545	c.292G>A	c.(292-294)Gat>Aat	p.D98N	COPRS_ENST00000302362.6_Missense_Mutation_p.D110N					coordinator of PRMT5, differentiation stimulator																		TTAAAAAGATCGCCAGGCTGT	0.517000													4	173					0	0	1	0	0
ALMS1P	0	broad.mit.edu	37	2	73901106	73901106	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:73901106G>A	ENST00000450720.1	+	0	904					NR_003683.2																						AATCGCATGCGCCCACTACCC	0.557000													4	3					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48250197	48250197	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:48250197G>A	ENST00000394747.1	-	6	1128	c.777_splice	c.e6-1	p.A260_splice	ABCC11_ENST00000353782.5_Splice_Site_p.A260_splice|ABCC11_ENST00000394748.1_Splice_Site_p.A260_splice|ABCC11_ENST00000356608.2_Splice_Site_p.A260_splice|ABCC11_ENST00000537808.1_Splice_Site_p.A260_splice	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	260	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GAAGCTGATGGCCTGCAAGAC	0.557000													39	39					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85326360	85326360	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:85326360C>T	ENST00000299927.3	+	1	476	c.454C>T	c.(454-456)Ccc>Tcc	p.P152S	ZNF592_ENST00000560079.2_Missense_Mutation_p.P152S			Q92610	ZN592_HUMAN	zinc finger protein 592	152					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ACCTGAGGATCCCATCAAAGA	0.557000													62	131					0	0	1	0	0
WDR70	55100	broad.mit.edu	37	5	37701190	37701190	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:37701190G>A	ENST00000265107.4	+	12	1379	c.1223G>A	c.(1222-1224)cGa>cAa	p.R408Q	WDR70_ENST00000510699.1_3'UTR	NM_018034.2	NP_060504.1	Q9NW82	WDR70_HUMAN	WD repeat domain 70	408										central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGGGACATCCGACAATTTAAT	0.368000													36	53					0	0	1	0	0
RCAN3	11123	broad.mit.edu	37	1	24861637	24861637	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24861637A>G	ENST00000374395.4	+	5	909	c.596A>G	c.(595-597)cAt>cGt	p.H199R	RCAN3_ENST00000374393.2_Missense_Mutation_p.M84V|RCAN3_ENST00000538532.1_Missense_Mutation_p.H141R|RCAN3_ENST00000436717.2_Missense_Mutation_p.H189R|RCAN3_ENST00000412742.2_Missense_Mutation_p.M142V	NM_001251978.1|NM_001251979.1|NM_001251984.1	NP_001238907.1|NP_001238908.1|NP_001238913.1	Q9UKA8	RCAN3_HUMAN	RCAN family member 3	199					anatomical structure morphogenesis|calcium-mediated signaling		nucleotide binding|RNA binding|troponin I binding			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)	7		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00473)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0427)|OV - Ovarian serous cystadenocarcinoma(117;1.13e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;0.000923)|BRCA - Breast invasive adenocarcinoma(304;0.0018)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.00493)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.14)		GTGGTGGTTCATGTCTGTGAA	0.498000													4	30					0	0	1	0	0
TIA1	7072	broad.mit.edu	37	2	70463280	70463280	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:70463280C>T	ENST00000433529.2	-	2	264	c.54G>A	c.(52-54)gtG>gtA	p.V18V	TIA1_ENST00000445587.1_Silent_p.V18V|TIA1_ENST00000415783.2_Silent_p.V18V|TIA1_ENST00000416149.2_Silent_p.V18V|TIA1_ENST00000282574.4_Silent_p.V18V|C2orf42_ENST00000470096.1_Intron	NM_022173.2	NP_071505.2	P31483	TIA1_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein	18	RRM 1.				apoptosis|induction of apoptosis|regulation of nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|poly(A) RNA binding|protein binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	17						GAGCTTCTGTCACATCTCTGG	0.353000													19	36					0	0	1	0	0
PBX1	5087	broad.mit.edu	37	1	164761860	164761860	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:164761860C>T	ENST00000420696.2	+	3	583	c.395C>T	c.(394-396)gCg>gTg	p.A132V	PBX1_ENST00000367897.1_Missense_Mutation_p.A132V|PBX1_ENST00000540246.1_Missense_Mutation_p.A27V|PBX1_ENST00000540236.1_Missense_Mutation_p.A132V|PBX1_ENST00000559240.1_Missense_Mutation_p.A132V|PBX1_ENST00000560641.1_Missense_Mutation_p.A27V|PBX1_ENST00000401534.1_Missense_Mutation_p.A132V	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	132	Poly-Ala.				negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						gcggcggcagcggcggcggcT	0.617000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								18	22					0	0	1	0	0
SAMM50	25813	broad.mit.edu	37	22	44373826	44373826	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:44373826C>T	ENST00000350028.4	+	10	1081	c.924C>T	c.(922-924)ctC>ctT	p.L308L	SAMM50_ENST00000396202.3_Silent_p.L98L	NM_015380.4	NP_056195.3	Q9Y512	SAM50_HUMAN	SAMM50 sorting and assembly machinery component	308					protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial sorting and assembly machinery complex	protein binding			endometrium(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				ACAAGCAACTCATATTTGATT	0.463000													4	8					0	0	1	0	0
UPP1	7378	broad.mit.edu	37	7	48147888	48147888	+	Silent	SNP	C	C	T	rs2230763	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:48147888C>T	ENST00000331803.4	+	10	1490	c.867C>T	c.(865-867)agC>agT	p.S289S	UPP1_ENST00000341253.4_Silent_p.S289S|UPP1_ENST00000395564.4_Silent_p.S289S|UPP1_ENST00000482015.1_3'UTR|UPP1_ENST00000429491.2_Silent_p.S152S			Q16831	UPP1_HUMAN	uridine phosphorylase 1	289					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	18						ATGTGCTCAGCGAGTACCAGC	0.602000													18	24					0	0	1	0	0
PPOX	5498	broad.mit.edu	37	1	161137271	161137271	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161137271C>T	ENST00000367999.4	+	4	599	c.333C>T	c.(331-333)ggC>ggT	p.G111G	PPOX_ENST00000535223.1_Intron|PPOX_ENST00000432542.2_Intron|PPOX_ENST00000352210.5_Silent_p.G111G|PPOX_ENST00000495483.1_3'UTR|PPOX_ENST00000544598.1_Intron	NM_001122764.1	NP_001116236.1	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	111					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(3)	15	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TACCCACTGGCCTCAGGTAAC	0.498000													4	11					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	136972228	136972228	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:136972228A>G	ENST00000359015.4	-	11	2042	c.1680_splice	c.e11-1	p.V561_splice	MAP3K5_ENST00000355845.4_5'UTR	NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	561					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TAATATTAATACCTTGAAAAG	0.368000													8	13					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65409031	65409031	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65409031C>T	ENST00000394224.3	+	2	935	c.639C>T	c.(637-639)gaC>gaT	p.D213D	SIPA1_ENST00000534313.1_Silent_p.D213D|SIPA1_ENST00000394227.3_Silent_p.D213D|SIPA1_ENST00000527525.1_Silent_p.D213D	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	213					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						AGCACGCAGACCTGGGTGCTG	0.622000													10	18					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128331595	128331595	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128331595C>T	ENST00000389524.4	+	7	746	c.693C>T	c.(691-693)cgC>cgT	p.R231R	MYO7B_ENST00000428314.1_Silent_p.R231R|MYO7B_ENST00000409816.2_Silent_p.R231R			Q6PIF6	MYO7B_HUMAN	myosin VIIB	231	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGGGCGCGCGCATCGAGCAAT	0.582000													10	54					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153137794	153137794	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153137794C>T	ENST00000370060.1	-	5	402	c.213G>A	c.(211-213)agG>agA	p.R71R	L1CAM_ENST00000538883.1_Silent_p.R73R|L1CAM_ENST00000543994.1_Silent_p.R73R|L1CAM_ENST00000370055.1_Silent_p.R66R|L1CAM_ENST00000370057.3_Silent_p.R71R|L1CAM_ENST00000361981.3_Silent_p.R66R|L1CAM_ENST00000361699.4_Silent_p.R71R	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	71	Ig-like C2-type 1.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGACACCATCCCTCGTCCAGC	0.617000													10	3					0	0	1	0	0
PXK	54899	broad.mit.edu	37	3	58381463	58381463	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58381463A>T	ENST00000463280.1	+	7	791	c.700A>T	c.(700-702)Aca>Tca	p.T234S	PXK_ENST00000536660.1_Missense_Mutation_p.T130S|PXK_ENST00000302779.5_Missense_Mutation_p.T250S|PXK_ENST00000383715.4_Missense_Mutation_p.T250S|PXK_ENST00000484288.1_Missense_Mutation_p.T267S|PXK_ENST00000479241.1_Missense_Mutation_p.T250S|PXK_ENST00000383716.3_Missense_Mutation_p.T234S|PXK_ENST00000356151.2_Missense_Mutation_p.T267S			Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	267	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		GCAAATAAAAACATATGGACG	0.358000													32	37					0	0	1	0	0
PCDHA10	0	broad.mit.edu	37	5	140237600	140237600	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140237600C>T	ENST00000307360.5	+	1	1967	c.1967C>T	c.(1966-1968)cCg>cTg	p.P656L	PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATGGCGAGCCGTCGCTGACG	0.682000													7	12					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242814203	242814203	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:242814203G>A	ENST00000343216.3	+	2	524	c.496G>A	c.(496-498)Gcc>Acc	p.A166T		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	166						integral to membrane											GAGCGCCAACGCCACAAAAGG	0.692000													3	8					0	0	1	0	0
HOXB9	3219	broad.mit.edu	37	17	46700277	46700277	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:46700277C>T	ENST00000311177.5	-	2	945	c.738G>A	c.(736-738)gaG>gaA	p.E246E	HOXB9_ENST00000550387.1_3'UTR|HOXB7_ENST00000567101.1_Intron	NM_024017.4	NP_076922.1	P17482	HXB9_HUMAN	homeobox B9	246					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|large_intestine(1)|liver(1)|lung(6)|prostate(1)	12						CTTTGCCCTGCTCCTTATTCA	0.473000													23	28					0	0	1	0	0
SLC17A5	26503	broad.mit.edu	37	6	74331564	74331564	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:74331564G>T	ENST00000355773.5	-	7	1209	c.941C>A	c.(940-942)aCt>aAt	p.T314N	SLC17A5_ENST00000393019.3_3'UTR	NM_012434.4	NP_036566.1	Q9NRA2	S17A5_HUMAN	solute carrier family 17 (acidic sugar transporter), member 5	314					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CTTCATATAAGTAGGCAATAA	0.343000													10	18					0.00621372	0.00628055	1	1	0
FOXA2	3170	broad.mit.edu	37	20	22563481	22563481	+	Silent	SNP	G	G	A	rs151323690		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:22563481G>A	ENST00000419308.2	-	2	583	c.381C>T	c.(379-381)taC>taT	p.Y127Y	FOXA2_ENST00000319993.4_Silent_p.Y133Y|FOXA2_ENST00000377115.4_Silent_p.Y127Y	NM_021784.4	NP_068556.2	Q9Y261	FOXA2_HUMAN	forkhead box A2	127					cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|urinary_tract(1)	22	Lung NSC(19;0.188)					TCATGTTGGCGTAGGGGGCCA	0.751000													19	21					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12382686	12382686	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12382686G>A	ENST00000358136.3	+	34	7928	c.7798G>A	c.(7798-7800)Gca>Aca	p.A2600T	VPS13D_ENST00000356315.4_Missense_Mutation_p.A2600T	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2600					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGCTAATGCTGCAGTGCCAGA	0.488000													20	37					0	0	1	0	0
SLC35F6	54978	broad.mit.edu	37	2	27001128	27001128	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27001128G>A	ENST00000344420.5	+	6	927	c.865G>A	c.(865-867)Gcc>Acc	p.A289T	CENPA_ENST00000475662.1_Intron|SLC35F6_ENST00000416475.2_Missense_Mutation_p.A206T	NM_017877.3	NP_060347.2			solute carrier family 35, member F6									p.A289T(1)									GGAACTGAGCGCCACCACCCG	0.617000													19	36					0	0	1	0	0
MRPL38	64978	broad.mit.edu	37	17	73897876	73897876	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73897876G>A	ENST00000309352.3	-	4	1045	c.508C>T	c.(508-510)Cga>Tga	p.R170*	MRPL38_ENST00000409963.3_5'UTR|MRPL38_ENST00000585475.1_5'UTR	NM_032478.3	NP_115867.2	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38	170						actin cytoskeleton|mitochondrion|ribosome				ovary(1)|pancreas(1)|prostate(2)|skin(1)	5			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGGGGGACTCGGGGCACAAAG	0.607000													4	19					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149430775	149430775	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149430775C>T	ENST00000255992.10	+	18	3128	c.2729C>T	c.(2728-2730)gCa>gTa	p.A910V	KRBA1_ENST00000319551.8_Missense_Mutation_p.A850V|KRBA1_ENST00000485033.2_Missense_Mutation_p.A850V|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	911										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCTCGCCGGGCACGTCCGCTG	0.662000													4	4					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100221465	100221465	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:100221465C>T	ENST00000524871.1	+	24	3353	c.3063C>T	c.(3061-3063)agC>agT	p.S1021S	CNTN5_ENST00000279463.3_Silent_p.S1021S|CNTN5_ENST00000528682.1_Silent_p.S1021S|CNTN5_ENST00000418526.2_Silent_p.S947S|CNTN5_ENST00000524560.1_3'UTR	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	1021	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ACAGCAACAGCCAAGTTATTG	0.383000													7	21					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70476261	70476261	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:70476261G>A	ENST00000260128.4	+	5	768	c.51G>A	c.(49-51)ttG>ttA	p.L17L	SULF1_ENST00000402687.4_Silent_p.L17L|SULF1_ENST00000419716.3_Silent_p.L17L|SULF1_ENST00000458141.2_Silent_p.L17L	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	17					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GCACAGAATTGCTGGGAAGCC	0.473000													21	85					0	0	1	0	0
CPNE9	151835	broad.mit.edu	37	3	9760187	9760187	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9760187C>T	ENST00000383832.3	+	17	1332	c.1142C>T	c.(1141-1143)gCg>gTg	p.A381V	CPNE9_ENST00000383831.3_Missense_Mutation_p.A381V	NM_153635.2	NP_705899.2	Q8IYJ1	CPNE9_HUMAN	copine family member IX	381	VWFA.									breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16	Medulloblastoma(99;0.227)					CCCAACTGTGCGGGCATCGAG	0.562000													19	27					0	0	1	0	0
TRAP1	10131	broad.mit.edu	37	16	3729744	3729744	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3729744C>T	ENST00000246957.5	-	5	607	c.519G>A	c.(517-519)ggG>ggA	p.G173G	TRAP1_ENST00000538171.1_Silent_p.G120G	NM_016292.2	NP_057376.2	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1	173					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(90;0.0261)				TGGCAATCGTCCCCAGGTTGG	0.637000													18	25					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107078653	107078653	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:107078653C>T	ENST00000229387.5	+	1	180	c.62C>T	c.(61-63)tCg>tTg	p.S21L	RFX4_ENST00000357881.4_Intron|RFX4_ENST00000392842.1_Intron|RP11-144F15.1_ENST00000551505.1_Intron	NM_032491.5	NP_115880.2	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	369					transcription, DNA-dependent	nucleus	DNA binding	p.S21L(1)		NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						cagatagattcgagatgccca	0.478000													7	11					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61499109	61499109	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61499109C>T	ENST00000424789.2	+	25	5770	c.5766C>T	c.(5764-5766)ccC>ccT	p.P1922P	TANC2_ENST00000389520.4_Silent_p.P1932P|RP11-269G24.3_ENST00000583552.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1922							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						ATTACAGCCCCCATGGGATGC	0.527000													3	39					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31850722	31850722	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31850722G>A	ENST00000395728.3	-	23	3229	c.3230C>T	c.(3229-3231)gCg>gTg	p.A1077V	EHMT2_ENST00000375528.4_Missense_Mutation_p.A1043V|EHMT2_ENST00000375530.4_Missense_Mutation_p.A986V|EHMT2_ENST00000375537.4_Missense_Mutation_p.A1020V|EHMT2_ENST00000480912.1_5'UTR			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1020	Interaction with histone H3 (By similarity).|SET.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						GCATGAGCACGCCTGGTTACA	0.562000													11	29					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7706925	7706925	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:7706925G>A	ENST00000338316.4	+	8	1267	c.1178G>A	c.(1177-1179)tGt>tAt	p.C393Y	ADCY2_ENST00000537121.1_Missense_Mutation_p.C213Y	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	393					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						AATGTCCTGTGTGGCGTGATT	0.507000													34	73					0	0	1	0	0
ING1	3621	broad.mit.edu	37	13	111371749	111371749	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:111371749C>T	ENST00000375774.3	+	2	1201	c.739C>T	c.(739-741)Cgg>Tgg	p.R247W	ING1_ENST00000333219.7_Missense_Mutation_p.R104W|ING1_ENST00000375775.3_Missense_Mutation_p.R35W|ING1_ENST00000464141.1_3'UTR|ING1_ENST00000338450.7_Missense_Mutation_p.R60W	NM_005537.4	NP_005528.3	Q9UK53	ING1_HUMAN	inhibitor of growth family, member 1	247					cell cycle|negative regulation of cell growth|negative regulation of cell proliferation	nucleus	zinc ion binding			endometrium(4)|large_intestine(6)|lung(1)|ovary(1)	12	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.188)			GAACCGCACGCGGCAGGTGGA	0.677000													22	25					0	0	1	0	0
ZBTB3	79842	broad.mit.edu	37	11	62519768	62519768	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62519768G>A	ENST00000394807.3	-	2	1644	c.1519C>T	c.(1519-1521)Cgg>Tgg	p.R507W		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						GTGTAGCTCCGCAGGCAGTAG	0.587000													19	35					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33656035	33656035	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33656035G>T	ENST00000374316.5	+	49	7455	c.6395G>T	c.(6394-6396)aGc>aTc	p.S2132I	ITPR3_ENST00000605930.1_Missense_Mutation_p.S2132I			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	2132					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						CAGGACCGCAGCATGGAGCAG	0.657000													22	30					5.35356e-11	5.74024e-11	1	1	0
OR10Z1	128368	broad.mit.edu	37	1	158576625	158576625	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158576625G>A	ENST00000361284.1	+	1	397	c.397G>A	c.(397-399)Gcc>Acc	p.A133T		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	133					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					ACTCCACTATGCCAGCCACAT	0.502000													24	31					0	0	1	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18194972	18194972	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18194972C>T	ENST00000314254.3	+	1	589	c.169C>T	c.(169-171)Cgc>Tgc	p.R57C	RP11-113D6.6_ENST00000527671.1_Intron	NM_054032.3	NP_473373.2	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	57						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						CTACCGCATGCGCAGGAACGC	0.537000													24	27					0	0	1	0	0
GYS1	2997	broad.mit.edu	37	19	49494707	49494707	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49494707G>A	ENST00000323798.3	-	2	348	c.152C>T	c.(151-153)gCg>gTg	p.A51V	GYS1_ENST00000544287.1_Intron|GYS1_ENST00000457974.1_5'UTR|GYS1_ENST00000540532.1_Intron|GYS1_ENST00000541188.1_Intron|GYS1_ENST00000263276.6_Missense_Mutation_p.A51V	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	51					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TGTCACCTTCGCCTTCGTCTG	0.672000													54	84					0	0	1	0	0
NEGR1	257194	broad.mit.edu	37	1	72748149	72748149	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:72748149G>A	ENST00000357731.4	-	1	268	c.29C>T	c.(28-30)gCt>gTt	p.A10V	NEGR1_ENST00000434200.1_Missense_Mutation_p.A8V	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	10					cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		CGAGCAACAAGCACCCTGCAC	0.647000													8	14					0	0	1	0	0
MST4	0	broad.mit.edu	37	X	131188701	131188701	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:131188701C>T	ENST00000394334.2	+	3	338	c.85C>T	c.(85-87)Cgc>Tgc	p.R29C	MST4_ENST00000496850.1_Missense_Mutation_p.R29C|MST4_ENST00000394335.2_Intron|MST4_ENST00000481105.1_Missense_Mutation_p.R29C|MST4_ENST00000354719.6_Missense_Mutation_p.R29C	NM_016542.3	NP_057626.2	Q9P289	MST4_HUMAN		29	Protein kinase.				cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(192;0.000127)					AAAATTAGAGCGCATTGGGAA	0.388000													26	7					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65607655	65607655	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:65607655G>A	ENST00000330909.8	-	2	421	c.422C>T	c.(421-423)gCt>gTt	p.A141V	MAGI1_ENST00000497477.2_Missense_Mutation_p.A141V|MAGI1_ENST00000402939.2_Missense_Mutation_p.A141V|MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000483466.1_Missense_Mutation_p.A141V	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	141	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		ACAAGGCACAGCATGGCGGTA	0.488000													17	24					0	0	1	0	0
CCDC3	83643	broad.mit.edu	37	10	12940631	12940631	+	Missense_Mutation	SNP	C	C	T	rs145872952		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:12940631C>T	ENST00000378839.1	-	7	1175	c.223G>A	c.(223-225)Gtc>Atc	p.V75I	CCDC3_ENST00000378825.3_Missense_Mutation_p.V200I			Q9BQI4	CCDC3_HUMAN	coiled-coil domain containing 3	200						endoplasmic reticulum|extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)	11		Ovarian(717;0.0822)	BRCA - Breast invasive adenocarcinoma(52;0.163)			AGTTTCTTGACGTGGTCCTCC	0.602000													18	42					0	0	1	0	0
GATAD2A	54815	broad.mit.edu	37	19	19609379	19609379	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19609379C>T	ENST00000404158.1	+	10	1470	c.1052C>T	c.(1051-1053)gCg>gTg	p.A351V	GATAD2A_ENST00000358713.3_Missense_Mutation_p.A351V|GATAD2A_ENST00000429563.2_Missense_Mutation_p.A178V|GATAD2A_ENST00000252577.5_Missense_Mutation_p.A351V|GATAD2A_ENST00000537887.1_5'UTR|GATAD2A_ENST00000360315.3_Missense_Mutation_p.A351V			Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	351					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13						GCCAAGCTGGCGCTGCGCAAA	0.652000													5	19					0	0	1	0	0
ALPI	248	broad.mit.edu	37	2	233323451	233323451	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:233323451C>T	ENST00000295463.3	+	10	1370	c.1293C>T	c.(1291-1293)agC>agT	p.S431S		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	431					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TGAATGAGAGCGAGAGCGGTG	0.652000													6	16					0	0	1	0	0
NLGN2	57555	broad.mit.edu	37	17	7317763	7317763	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7317763C>A	ENST00000302926.2	+	3	682	c.609C>A	c.(607-609)gcC>gcA	p.A203A	NLGN2_ENST00000575301.1_Silent_p.A203A	NM_020795.2	NP_065846.1	Q8NFZ4	NLGN2_HUMAN	neuroligin 2	203					cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|prostate(2)|skin(3)	22		Prostate(122;0.157)				TCCTGGCTGCCTATGGCAACG	0.607000													22	34					4.26978e-12	4.60954e-12	1	1	0
ANKRD44	91526	broad.mit.edu	37	2	197870470	197870470	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:197870470A>G	ENST00000328737.2	-	21	2296	c.2220T>C	c.(2218-2220)tgT>tgC	p.C740C	ANKRD44_ENST00000450567.1_Silent_p.C740C|ANKRD44_ENST00000337207.5_Silent_p.C740C|ANKRD44_ENST00000282272.8_Silent_p.C757C			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	765							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTTTGAAACAACAGTCCTCCT	0.532000													29	41					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32728305	32728305	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:32728305T>C	ENST00000421745.2	+	49	9633		c.e49+2			NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6						anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CACCCCTCGGTAAGAAAAGTG	0.348000													6	7					0	0	1	0	0
C11orf16	56673	broad.mit.edu	37	11	8942944	8942944	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:8942944C>T	ENST00000326053.5	-	6	1429	c.1323G>A	c.(1321-1323)ccG>ccA	p.P441P	C11orf16_ENST00000525780.1_Intron	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	441										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		GCGGGGTCCGCGGTGGCTTCA	0.522000													42	78					0	0	1	0	0
RBM19	9904	broad.mit.edu	37	12	114397934	114397934	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:114397934C>T	ENST00000545145.2	-	3	347	c.269G>A	c.(268-270)aGc>aAc	p.S90N	RBM19_ENST00000392561.3_Missense_Mutation_p.S90N|RBM19_ENST00000261741.5_Missense_Mutation_p.S90N	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	90					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GGCATGTTTGCTCCAGGCTCT	0.527000													18	21					0	0	1	0	0
ZNF225	7768	broad.mit.edu	37	19	44635250	44635250	+	Silent	SNP	C	C	T	rs150004406	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44635250C>T	ENST00000262894.6	+	5	763	c.483C>T	c.(481-483)tcC>tcT	p.S161S	ZNF225_ENST00000590612.1_Silent_p.S161S|ZNF225_ENST00000592780.1_3'UTR	NM_013362.2	NP_037494.2	Q9UK10	ZN225_HUMAN	zinc finger protein 225	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				GTGATGTCTCCGTCCTTGATC	0.413000													27	33					0	0	1	0	0
TAS2R50	259296	broad.mit.edu	37	12	11139200	11139200	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:11139200G>A	ENST00000506868.1	-	1	311	c.260C>T	c.(259-261)gCc>gTc	p.A87V	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176890.2	NP_795371.2	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	87					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)	17						TACAACCCAGGCATTATAAGA	0.348000													4	94					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5473844	5473844	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:5473844G>A	ENST00000296564.7	+	16	6618	c.6396G>A	c.(6394-6396)acG>acA	p.T2132T		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	2132										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						GGATCTGGACGCATGATAACA	0.328000													10	17					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183976188	183976188	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:183976188C>T	ENST00000324557.4	+	3	638	c.593C>T	c.(592-594)gCt>gTt	p.A198V	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000402825.3_Intron	NM_032331.3	NP_115707.2	O60344	ECE2_HUMAN	endothelin converting enzyme 2	0					brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTGAGGCATGCTACCTATGGC	0.582000													40	75					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99193459	99193459	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:99193459G>A	ENST00000074304.5	+	25	3047	c.2654G>A	c.(2653-2655)cGc>cAc	p.R885H	INPP4A_ENST00000409540.3_Missense_Mutation_p.R846H|INPP4A_ENST00000523221.1_Missense_Mutation_p.R885H|INPP4A_ENST00000545415.1_Missense_Mutation_p.R846H|INPP4A_ENST00000409851.3_Missense_Mutation_p.R880H|INPP4A_ENST00000409016.3_Missense_Mutation_p.R846H|INPP4A_ENST00000409463.1_Missense_Mutation_p.R214H	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	885					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						CAGATCTGCCGCCGCCTTAAT	0.592000													22	40					0	0	1	0	0
KLHL26	55295	broad.mit.edu	37	19	18778931	18778931	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18778931C>T	ENST00000300976.4	+	3	814	c.724C>T	c.(724-726)Ccg>Tcg	p.P242S	KLHL26_ENST00000599006.1_Intron	NM_018316.1	NP_060786.1	Q53HC5	KLH26_HUMAN	kelch-like family member 26	242	BACK.									breast(1)|central_nervous_system(1)|kidney(1)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						ggcccggcggccgcgcgccAG	0.677000													8	11					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109371498	109371498	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:109371498G>A	ENST00000283195.6	+	16	2466	c.2340G>A	c.(2338-2340)ccG>ccA	p.P780P		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	780					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						ATTCTACACCGTCTCCTACCA	0.353000													6	265					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113342297	113342297	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:113342297G>A	ENST00000264852.4	+	22	2840	c.2114G>A	c.(2113-2115)cGc>cAc	p.R705H	SIDT1_ENST00000463226.1_3'UTR|SIDT1_ENST00000393830.3_Missense_Mutation_p.R710H	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	705						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						TTGATATACCGCCCCAGGGAC	0.527000													58	89					0	0	1	0	0
HGFAC	3083	broad.mit.edu	37	4	3446574	3446574	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:3446574C>T	ENST00000382774.3	+	8	985	c.870C>T	c.(868-870)aaC>aaT	p.N290N	HGFAC_ENST00000511533.1_Silent_p.N290N	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	290	Kringle.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TCTTGGGGAACGGCACTGGGT	0.711000													3	1					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45867591	45867591	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:45867591C>T	ENST00000311275.7	-	15	2769	c.2516G>A	c.(2515-2517)cGt>cAt	p.R839H	ZMYND8_ENST00000352431.2_Intron|ZMYND8_ENST00000540497.1_Missense_Mutation_p.R787H|ZMYND8_ENST00000458360.2_Intron|ZMYND8_ENST00000396281.4_Missense_Mutation_p.R839H|ZMYND8_ENST00000262975.4_Intron|ZMYND8_ENST00000536340.1_Missense_Mutation_p.R866H|ZMYND8_ENST00000471951.2_Missense_Mutation_p.R859H|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000355972.4_Missense_Mutation_p.R839H|ZMYND8_ENST00000372023.3_Intron|ZMYND8_ENST00000360911.3_Intron|ZMYND8_ENST00000461685.1_Intron|ZMYND8_ENST00000446994.2_Intron			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	839	Poly-Gln.						protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			ctgctgctgacgctgcATCTT	0.567000													23	43					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56679761	56679761	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56679761C>A	ENST00000389934.3	-	12	1644	c.1527_splice	c.e12+1	p.K509_splice	TEX14_ENST00000349033.5_Splice_Site_p.K509_splice|TEX14_ENST00000240361.8_Splice_Site_p.K515_splice	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	515	Protein kinase.					cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CAGGGCTTGCCTTTAAGTCAT	0.393000													32	43					3.86903e-22	4.30158e-22	1	1	0
ZZEF1	23140	broad.mit.edu	37	17	4020385	4020385	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4020385C>T	ENST00000381638.2	-	3	699	c.575G>A	c.(574-576)cGc>cAc	p.R192H	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	192							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GAGCCGATTGCGGTGCAGGAA	0.507000													17	66					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53547765	53547765	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:53547765C>T	ENST00000371500.3	+	12	2202	c.1861C>T	c.(1861-1863)Cgt>Tgt	p.R621C	PODN_ENST00000312553.5_Missense_Mutation_p.R640C|PODN_ENST00000395871.2_Missense_Mutation_p.R498C|RP11-334A14.5_ENST00000447867.1_RNA	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	592					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TTCCAAGGACCGTGGCCGCTT	0.547000													18	23					0	0	1	0	0
KLC2	64837	broad.mit.edu	37	11	66031140	66031140	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66031140C>T	ENST00000394065.2	+	4	1363	c.345C>T	c.(343-345)aaC>aaT	p.N115N	KLC2_ENST00000394078.1_Intron|KLC2_ENST00000316924.5_Silent_p.N254N|KLC2_ENST00000394067.2_Silent_p.N254N|KLC2_ENST00000421552.1_Silent_p.N177N|KLC2_ENST00000394066.2_Silent_p.N177N|KLC2_ENST00000417856.1_Silent_p.N254N			Q9H0B6	KLC2_HUMAN	kinesin light chain 2	254					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						GGGATCAGAACAAGTACAAGG	0.597000													13	16					0	0	1	0	0
TAS2R13	50838	broad.mit.edu	37	12	11061452	11061452	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:11061452T>C	ENST00000390677.2	-	1	709	c.446A>G	c.(445-447)aAc>aGc	p.N149S	PRR4_ENST00000536668.1_Intron	NM_023920.2	NP_076409.1	Q9NYV9	T2R13_HUMAN	taste receptor, type 2, member 13	149			N -> S (in a breast cancer sample; somatic mutation).		sensory perception of taste	integral to membrane	taste receptor activity	p.N149S(1)		breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9						TATATGCATGTTTATTTGTAT	0.353000													26	49					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39227656	39227656	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:39227656C>T	ENST00000340369.3	-	2	3509	c.3281G>A	c.(3280-3282)cGg>cAg	p.R1094Q	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.R1094Q	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1094							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCCAGCTTTCCGAAGACCGTC	0.592000													31	33					0	0	1	0	0
TRIP10	9322	broad.mit.edu	37	19	6743769	6743769	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6743769C>T	ENST00000600428.1	+	7	886	c.240C>T	c.(238-240)aaC>aaT	p.N80N	TRIP10_ENST00000313285.8_Silent_p.N188N|TRIP10_ENST00000596758.1_Silent_p.N188N|TRIP10_ENST00000313244.9_Silent_p.N188N			Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	188	Induction of membrane tubulation.|Required for podosome formation and interaction with AKAP9 and microtubules.|Required for translocation to the plasma membrane in response to insulin (By similarity).				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	16						AAAGCAAAAACGAATATGCGG	0.527000													19	25					0	0	1	0	0
MS4A8	83661	broad.mit.edu	37	11	60482851	60482851	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:60482851A>G	ENST00000300226.2	+	7	920	c.717A>G	c.(715-717)ccA>ccG	p.P239P		NM_031457.1	NP_113645.1			membrane-spanning 4-domains, subfamily A, member 8																		TGACCTCACCACCAAGTTATT	0.488000													12	15					0	0	1	0	0
C16orf91	283951	broad.mit.edu	37	16	1478455	1478455	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1478455T>C	ENST00000310355.1	-	2	195	c.196A>G	c.(196-198)Agc>Ggc	p.S66G				Q4G0I0	CSMT1_HUMAN	chromosome 16 open reading frame 91	0						integral to membrane				breast(1)|endometrium(1)|kidney(1)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11						GAGGCCGAGCTGAGGTCCACC	0.682000													9	10					0	0	1	0	0
PTBP1	5725	broad.mit.edu	37	19	804602	804602	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:804602C>T	ENST00000356948.6	+	6	929	c.506C>T	c.(505-507)gCg>gTg	p.A169V	PTBP1_ENST00000394601.4_Missense_Mutation_p.A169V|PTBP1_ENST00000350092.4_Intron|PTBP1_ENST00000349038.4_Missense_Mutation_p.A169V	NM_002819.4	NP_002810.1	P26599	PTBP1_HUMAN	polypyrimidine tract binding protein 1	169					negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)	19		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTCGGCGGCGGCCGTGGAC	0.701000													17	23					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228134636	228134636	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:228134636C>T	ENST00000396578.3	+	24	1677	c.1515C>T	c.(1513-1515)ggC>ggT	p.G505G	AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	505	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GAAGACAAGGCGCAGCTGGCT	0.398000													11	15					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924725	188924725	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:188924725G>A	ENST00000326866.4	+	4	1172	c.764G>A	c.(763-765)cGc>cAc	p.R255H	ZFP42_ENST00000509524.1_Missense_Mutation_p.R255H	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	255					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TGCGGAAAGCGCTTCTCTCTG	0.498000													20	35					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086757	100086757	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100086757G>A	ENST00000423930.1	+	4	1572	c.1413G>A	c.(1411-1413)acG>acA	p.T471T	NYAP1_ENST00000300179.2_Silent_p.T471T|NYAP1_ENST00000454988.1_Silent_p.T414T			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	471																	AGGTGACCACGCACTCTGTCC	0.672000													4	7					0	0	1	0	0
KLK6	5653	broad.mit.edu	37	19	51466703	51466703	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:51466703G>A	ENST00000376851.3	-	4	739	c.300C>T	c.(298-300)gcC>gcT	p.A100A	KLK6_ENST00000310157.2_Silent_p.A100A|KLK6_ENST00000391808.1_5'UTR|KLK6_ENST00000594641.1_Silent_p.A100A|CTB-147C22.8_ENST00000601506.1_RNA|KLK6_ENST00000376853.4_Intron	NM_001012964.1	NP_001012982.1	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6	100	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|skin(4)	13		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		CATGGCTGGCGGCATCATAGT	0.582000													12	13					0	0	1	0	0
BCAR1	9564	broad.mit.edu	37	16	75268802	75268802	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:75268802G>T	ENST00000546196.1	-	5	3560	c.1908C>A	c.(1906-1908)gaC>gaA	p.D636E	BCAR1_ENST00000393420.6_Missense_Mutation_p.D683E|BCAR1_ENST00000542031.2_Missense_Mutation_p.D663E|BCAR1_ENST00000538440.2_Missense_Mutation_p.D665E|BCAR1_ENST00000420641.3_Missense_Mutation_p.D683E|BCAR1_ENST00000535626.2_Missense_Mutation_p.D517E|BCAR1_ENST00000393422.2_Missense_Mutation_p.D683E|BCAR1_ENST00000418647.3_Missense_Mutation_p.D711E|BCAR1_ENST00000566982.1_5'UTR|BCAR1_ENST00000162330.5_Missense_Mutation_p.D665E			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	665					actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGTGGACGTAGTCATAGTCCT	0.642000													16	24					1.15088e-07	1.20771e-07	1	1	0
ATP6V0A1	535	broad.mit.edu	37	17	40652859	40652859	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40652859C>T	ENST00000343619.4	+	16	1937	c.1814C>T	c.(1813-1815)gCa>gTa	p.A605V	ATP6V0A1_ENST00000544137.1_Missense_Mutation_p.A251V|ATP6V0A1_ENST00000546249.1_Missense_Mutation_p.A605V|ATP6V0A1_ENST00000393829.2_Missense_Mutation_p.A605V|ATP6V0A1_ENST00000537728.1_Missense_Mutation_p.A562V|ATP6V0A1_ENST00000264649.6_Missense_Mutation_p.A612V|ATP6V0A1_ENST00000585525.1_Missense_Mutation_p.A562V	NM_001130021.1	NP_001123493.1	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	605					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		TCTGAGAATGCACCAAGCCTT	0.408000													43	71					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19136509	19136509	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19136509T>C	ENST00000601879.1	-	3	945	c.648A>G	c.(646-648)ctA>ctG	p.L216L	SUGP2_ENST00000337018.6_Silent_p.L216L|SUGP2_ENST00000598202.1_5'UTR|SUGP2_ENST00000456085.2_Intron|SUGP2_ENST00000452918.2_Silent_p.L216L|SUGP2_ENST00000600377.1_Silent_p.L230L			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	216					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CAACGATGTTTAGAGCTCGAC	0.557000													23	43					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80369158	80369158	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:80369158C>T	ENST00000265080.4	+	5	841	c.774C>T	c.(772-774)taC>taT	p.Y258Y	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	258	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AGTCAGAGTACGTTCACCAGC	0.537000													10	54					0	0	1	0	0
PAXIP1	22976	broad.mit.edu	37	7	154767949	154767949	+	Silent	SNP	G	G	A	rs117838262	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:154767949G>A	ENST00000404141.1	-	6	685	c.531C>T	c.(529-531)gaC>gaT	p.D177D	PAXIP1_ENST00000473219.1_5'UTR|PAXIP1_ENST00000397192.1_Silent_p.D177D			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	177	BRCT 2.|Interaction with PA1 (By similarity).				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		AAAATGCTTCGTCCTTTTTGG	0.403000													23	23					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238053225	238053225	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:238053225C>T	ENST00000366570.4	-	3	500	c.342G>A	c.(340-342)gcG>gcA	p.A114A	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	114			A -> V (in dbSNP:rs34370253).		acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TGTGTTCAGCCGCGCCTGCTC	0.572000													57	99					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17696281	17696281	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:17696281A>G	ENST00000353383.1	+	3	488	c.19A>G	c.(19-21)Agg>Ggg	p.R7G	RAI1_ENST00000261641.6_Missense_Mutation_p.R7G	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	7						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		TTTTCGAGAAAGGTGTGGTTT	0.557000													8	12					0	0	1	0	0
TMEM255B	348013	broad.mit.edu	37	13	114469150	114469150	+	Missense_Mutation	SNP	G	G	A	rs149974408		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:114469150G>A	ENST00000375353.3	+	2	136	c.109G>A	c.(109-111)Gtc>Atc	p.V37I		NM_182614.2	NP_872420.1			transmembrane protein 255B																		GCTGGTGTCCGTCCTCATAGT	0.632000													8	51					0	0	1	0	0
ARMC6	93436	broad.mit.edu	37	19	19154809	19154809	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19154809C>T	ENST00000535612.1	+	4	637	c.205C>T	c.(205-207)Ctg>Ttg	p.L69L	ARMC6_ENST00000546344.1_Intron|ARMC6_ENST00000392335.2_Silent_p.L44L|ARMC6_ENST00000269932.6_Silent_p.L44L|ARMC6_ENST00000392336.3_Silent_p.L69L	NM_001199196.1	NP_001186125.1	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	69							protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|prostate(1)	14			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			AGGGGTTGATCTGAGCAACAT	0.572000													14	28					0	0	1	0	0
KLHL11	55175	broad.mit.edu	37	17	40010842	40010842	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40010842T>C	ENST00000319121.3	-	2	1337	c.1277A>G	c.(1276-1278)tAt>tGt	p.Y426C		NM_018143.1	NP_060613.1	Q9NVR0	KLH11_HUMAN	kelch-like family member 11	426						extracellular region				NS(2)|breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17		Breast(137;0.00156)				ATTTGGGTTATACCTTTCTAC	0.398000													57	72					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35700341	35700341	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35700341G>T	ENST00000314888.9	-	49	6860	c.6507C>A	c.(6505-6507)acC>acA	p.T2169T	TLN1_ENST00000540444.1_Silent_p.T2057T	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	2169					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTGGGGTAGAGGTCTTGGCAG	0.522000													26	29					1.16021e-09	1.23406e-09	1	1	0
BCKDK	10295	broad.mit.edu	37	16	31123313	31123313	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31123313C>T	ENST00000394951.1	+	12	1682	c.1059C>T	c.(1057-1059)gaC>gaT	p.D353D	BCKDK_ENST00000394950.3_Silent_p.D353D|BCKDK_ENST00000287507.3_Silent_p.D323D|BCKDK_ENST00000219794.6_Silent_p.D353D			O14874	BCKD_HUMAN	branched chain ketoacid dehydrogenase kinase	353	Histidine kinase.				branched chain family amino acid catabolic process|peptidyl-histidine phosphorylation	mitochondrial alpha-ketoglutarate dehydrogenase complex	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity|ATP binding|protein binding|protein serine/threonine kinase activity|two-component sensor activity			breast(1)|stomach(1)	2						GCCATCTGGACATGCATAGTG	0.622000													5	27					0	0	1	0	0
KLHL25	64410	broad.mit.edu	37	15	86312337	86312337	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:86312337G>A	ENST00000337975.5	-	2	979	c.705C>T	c.(703-705)agC>agT	p.S235S	KLHL25_ENST00000559131.1_Intron|KLHL25_ENST00000536947.1_Silent_p.S235S	NM_022480.3	NP_071925.2	Q9H0H3	ENC2_HUMAN	kelch-like family member 25	235						cytoplasm		p.S235S(1)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	25						CCAGACGCACGCTGCGGAGGA	0.657000													4	12					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113194840	113194840	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:113194840A>G	ENST00000401783.2	-	31	5471	c.5135T>C	c.(5134-5136)gTa>gCa	p.V1712A	SVEP1_ENST00000374469.1_Missense_Mutation_p.V1689A	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1712	Sushi 6.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTGGTAGGTTACTGTGCTGCC	0.502000													16	66					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	145069579	145069579	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:145069579G>A	ENST00000367545.3	+	54	8137	c.8137G>A	c.(8137-8139)Gtg>Atg	p.V2713M	UTRN_ENST00000367526.4_Missense_Mutation_p.V268M	NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	2713					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GGCAGAGTCCGTGCGGAATGG	0.488000													24	43					0	0	1	0	0
RAD18	56852	broad.mit.edu	37	3	8981263	8981263	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:8981263C>T	ENST00000264926.2	-	6	795	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K		NM_020165.3	NP_064550.3	Q9NS91	RAD18_HUMAN	RAD18 homolog (S. cerevisiae)	227					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(3)	15				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		TTCTTCTCTTCGCGTGATAAA	0.403000								Rad6 pathway					9	56					0	0	1	0	0
PWWP2B	170394	broad.mit.edu	37	10	134218982	134218982	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:134218982G>A	ENST00000305233.5	+	2	1037	c.978G>A	c.(976-978)gcG>gcA	p.A326A	PWWP2B_ENST00000368609.4_Silent_p.A326A	NM_138499.3	NP_612508.3	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2B	326										central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		CGGCCGGCGCGGACCTGCCGC	0.716000													13	9					0	0	1	0	0
CHIC2	26511	broad.mit.edu	37	4	54915146	54915146	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:54915146C>T	ENST00000263921.3	-	3	695	c.306G>A	c.(304-306)tgG>tgA	p.W102*	CHIC2_ENST00000512964.1_Nonsense_Mutation_p.W102*|FIP1L1_ENST00000507166.1_Intron	NM_012110.3	NP_036242.1	Q9UKJ5	CHIC2_HUMAN	cysteine-rich hydrophobic domain 2	102						plasma membrane	protein binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)	4	all_cancers(7;0.0193)|all_neural(26;0.0209)|Lung NSC(11;0.0281)|Glioma(25;0.08)		LUSC - Lung squamous cell carcinoma(32;0.00216)			AAATAACTGGCCACATACTGC	0.343000			T	ETV6	AML								9	8					0	0	1	0	0
PRPF38B	55119	broad.mit.edu	37	1	109241902	109241902	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109241902C>T	ENST00000370021.1	+	7	1205	c.568C>T	c.(568-570)Cgc>Tgc	p.R190C	PRPF38B_ENST00000370025.4_Missense_Mutation_p.R301C			Q5VTL8	PR38B_HUMAN	pre-mRNA processing factor 38B	301					mRNA processing|RNA splicing	spliceosomal complex				NS(1)|kidney(3)|large_intestine(5)|lung(8)|prostate(1)|skin(1)	19		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		AGAGAAAGAACGCCAGCGACT	0.517000													14	30					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	5924497	5924497	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:5924497G>A	ENST00000378156.4	-	28	4162	c.3897C>T	c.(3895-3897)ggC>ggT	p.G1299G	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	1299					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		CAAAGCGGCTGCCGGCCCTAA	0.647000													6	14					0	0	1	0	0
OR4D10	390197	broad.mit.edu	37	11	59245449	59245449	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:59245449C>T	ENST00000530162.1	+	1	604	c.547C>T	c.(547-549)Cgg>Tgg	p.R183W		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R181W(1)		NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TGATGTCCACCGGGTCCTCAA	0.493000													14	82					0	0	1	0	0
SRM	6723	broad.mit.edu	37	1	11119363	11119363	+	Silent	SNP	G	G	A	rs34097618		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11119363G>A	ENST00000376957.2	-	2	287	c.207C>T	c.(205-207)atC>atT	p.I69I		NM_003132.2	NP_003123.2	P19623	SPEE_HUMAN	spermidine synthase	69					spermidine biosynthetic process	cytosol	protein homodimerization activity|spermidine synthase activity			large_intestine(1)|lung(1)|urinary_tract(1)	3	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.228)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)	S-Adenosylmethionine(DB00118)|Spermine(DB00127)	CCGTGCACTGGATGACACCGT	0.612000													30	33					0	0	1	0	0
NUMA1	0	broad.mit.edu	37	11	71725990	71725990	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:71725990C>A	ENST00000393695.3	-	15	2890	c.2559G>T	c.(2557-2559)aaG>aaT	p.K853N	NUMA1_ENST00000351960.6_Intron|NUMA1_ENST00000358965.6_Missense_Mutation_p.K853N|RP11-849H4.4_ENST00000502284.1_RNA	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	853					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CCACCTTCTCCTTTGCCTCCT	0.582000			T	RARA	APL								11	53					1.58986e-06	1.65464e-06	1	1	0
RPSAP52	0	broad.mit.edu	37	12	66151935	66151935	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:66151935G>A	ENST00000489520.2	-	0	1008					NR_026825.2																						CCATTCAGTGGCCTGAGCAGT	0.483000													5	5					0	0	1	0	0
ZNF76	7629	broad.mit.edu	37	6	35261620	35261620	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:35261620T>C	ENST00000373953.3	+	12	1688	c.1422T>C	c.(1420-1422)ccT>ccC	p.P474P	ZNF76_ENST00000440666.2_Silent_p.P448P|ZNF76_ENST00000339411.5_Intron	NM_003427.3	NP_003418.2	P36508	ZNF76_HUMAN	zinc finger protein 76	474					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						TCCCCAGTCCTGATGCCGACC	0.632000													14	22					0	0	1	0	0
NEMF	9147	broad.mit.edu	37	14	50301159	50301159	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:50301159G>A	ENST00000298310.5	-	7	1032	c.583C>T	c.(583-585)Cca>Tca	p.P195S	AL627171.1_ENST00000358799.1_Intron|NEMF_ENST00000545773.1_Missense_Mutation_p.P153S|NEMF_ENST00000546046.1_Missense_Mutation_p.P195S			O60524	NEMF_HUMAN	nuclear export mediator factor	195						cytoplasm|nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(13)|liver(1)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	36						ATGAGAGCTGGTCCATAGGCT	0.353000													9	33					0	0	1	0	0
PRPF40B	25766	broad.mit.edu	37	12	50037897	50037897	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:50037897G>A	ENST00000261897.1	+	25	3050	c.2499G>A	c.(2497-2499)acG>acA	p.T833T	PRPF40B_ENST00000380281.1_Silent_p.T846T|PRPF40B_ENST00000548825.2_Silent_p.T867T|FMNL3_ENST00000335154.5_3'UTR			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	846					mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						GCTGGGACACGTCAGAAAGTG	0.597000											OREG0021798	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	21					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76344440	76344440	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:76344440C>T	ENST00000370014.3	+	5	990	c.371C>T	c.(370-372)aCg>aTg	p.T124M	SENP6_ENST00000370010.2_Missense_Mutation_p.T124M|SENP6_ENST00000447266.2_Missense_Mutation_p.T124M|SENP6_ENST00000327284.8_Missense_Mutation_p.T124M	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6	124					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				ACGCAAAATACGTCATTATGT	0.313000													12	33					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54803281	54803281	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:54803281G>T	ENST00000293379.4	-	3	711	c.450C>A	c.(448-450)ggC>ggA	p.G150G	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	150					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						AGATGGAGGAGCCATGGGCTC	0.642000													5	9					0.014758	0.0148771	1	1	0
EDC4	23644	broad.mit.edu	37	16	67913871	67913871	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67913871C>T	ENST00000358933.5	+	16	2179	c.1940C>T	c.(1939-1941)aCc>aTc	p.T647I		NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	647	Ser-rich.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CCCTCCTTGACCAGGTGAGGC	0.622000													9	9					0	0	1	0	0
GGNBP2	79893	broad.mit.edu	37	17	34913159	34913159	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:34913159A>G	ENST00000304718.4	+	4	727	c.411A>G	c.(409-411)acA>acG	p.T137T		NM_024835.3	NP_079111.1	Q9H3C7	GGNB2_HUMAN	gametogenetin binding protein 2	137					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)	38		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		AGCTTTATACATTATTTTATG	0.388000													10	36					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17523051	17523051	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:17523051A>G	ENST00000005226.7	-	22	2257	c.2258T>C	c.(2257-2259)gTc>gCc	p.V753A	USH1C_ENST00000529563.1_5'UTR|USH1C_ENST00000527020.1_Missense_Mutation_p.V434A|USH1C_ENST00000527720.1_Missense_Mutation_p.V422A|USH1C_ENST00000318024.4_Missense_Mutation_p.V453A	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	453					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						TAGGAGCCGGACATCCTTCCC	0.602000													15	15					0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17418039	17418039	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:17418039C>A	ENST00000470360.1	+	11	1735	c.1618C>A	c.(1618-1620)Cta>Ata	p.L540I	SLC7A2_ENST00000004531.10_Missense_Mutation_p.L541I|SLC7A2_ENST00000522656.1_Missense_Mutation_p.L501I|SLC7A2_ENST00000398090.3_Missense_Mutation_p.L540I|SLC7A2_ENST00000494857.1_Missense_Mutation_p.L501I			P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	501					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	GGTAGGATTCCTAGGTAAGTC	0.507000													9	54					1.12685e-05	1.16601e-05	1	1	0
GLTSCR1	29998	broad.mit.edu	37	19	48183474	48183474	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:48183474G>A	ENST00000396720.3	+	6	1241	c.1047G>A	c.(1045-1047)acG>acA	p.T349T	CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_015711.3	NP_056526.3	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	349							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|pancreas(3)|prostate(4)|skin(2)	20		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		GCACACCCACGCCCATCCAGC	0.746000													7	4					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37168467	37168467	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:37168467G>A	ENST00000262879.6	+	17	2712	c.2428G>A	c.(2428-2430)Gtg>Atg	p.V810M	RALGAPB_ENST00000397038.1_Missense_Mutation_p.V588M|RALGAPB_ENST00000397040.1_Missense_Mutation_p.V810M|RALGAPB_ENST00000397042.3_Missense_Mutation_p.V806M			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	810					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						CATCAGTTCTGTGTGCACCTA	0.468000													10	39					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25966166	25966166	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:25966166G>A	ENST00000435504.4	-	13	3333	c.3040C>T	c.(3040-3042)Cca>Tca	p.P1014S	ASXL2_ENST00000336112.4_Missense_Mutation_p.P986S|ASXL2_ENST00000272341.4_Intron|ASXL2_ENST00000404843.1_Intron			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	1014					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCGTAGCTGGATGGGACTGT	0.527000													10	11					0	0	1	0	0
GNB3	2784	broad.mit.edu	37	12	6954960	6954960	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6954960C>T	ENST00000229264.3	+	10	1315	c.910C>T	c.(910-912)Cgt>Tgt	p.R304C	GNB3_ENST00000435982.2_Missense_Mutation_p.R303C|CDCA3_ENST00000422785.3_3'UTR|CDCA3_ENST00000604599.1_5'UTR	NM_002075.2	NP_002066.1	P16520	GBB3_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 3	304					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|stomach(1)	20						GAAGTCTGAGCGTGTGGGTAA	0.617000													35	61					0	0	1	0	0
FFAR3	2865	broad.mit.edu	37	19	35850518	35850518	+	Silent	SNP	C	C	T	rs147416906		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35850518C>T	ENST00000327809.4	+	2	927	c.726C>T	c.(724-726)aaC>aaT	p.N242N	FFAR3_ENST00000594310.1_Silent_p.N242N	NM_005304.3	NP_005295.1	O14843	FFAR3_HUMAN	free fatty acid receptor 3	242						integral to plasma membrane	G-protein coupled receptor activity|lipid binding	p.N242N(1)|p.N242K(1)		endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|stomach(1)	17	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			GGCCCTACAACGTGTCCCATG	0.632000													34	140					0	0	1	0	0
ZNF586	54807	broad.mit.edu	37	19	58301720	58301720	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58301720C>A	ENST00000598183.1	+	2	291	c.115C>A	c.(115-117)Ctg>Atg	p.L39M	ZNF586_ENST00000598885.1_Missense_Mutation_p.L39M|ZNF586_ENST00000599802.1_Intron			Q9NXT0	ZN586_HUMAN	zinc finger protein 586	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)	15		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCAGGGATGCCTGTACCATGA	0.478000													63	84					1.74971e-23	1.95019e-23	1	1	0
SLC22A5	6584	broad.mit.edu	37	5	131714145	131714145	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:131714145T>C	ENST00000245407.3	+	2	690	c.469T>C	c.(469-471)Tcc>Ccc	p.S157P	SLC22A5_ENST00000435065.2_Missense_Mutation_p.S181P	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	157					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GCTGTTGGGCTCCTTCATTTC	0.557000													61	96					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3704646	3704646	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3704646G>A	ENST00000324932.7	-	30	5122	c.4702C>T	c.(4702-4704)Ctg>Ttg	p.L1568L	NUP98_ENST00000359171.4_Silent_p.L1494L|NUP98_ENST00000355260.3_Silent_p.L1494L	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1585					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CGGGTAAGCAGCTCTCGAACA	0.527000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								11	30					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36486906	36486906	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36486906T>C	ENST00000342292.4	-	11	2566	c.2546A>G	c.(2545-2547)aAg>aGg	p.K849R		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	849						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GAGCAAGGCCTTTTCCCTGGA	0.657000													15	13					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11031734	11031734	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11031734A>G	ENST00000327064.4	+	14	1736	c.1546A>G	c.(1546-1548)Acc>Gcc	p.T516A	CARM1_ENST00000344150.4_Missense_Mutation_p.T516A	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	516	Transactivation domain (By similarity).				cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						AGGGATGCCGACCGCCTATGA	0.662000													9	25					0	0	1	0	0
SVOPL	136306	broad.mit.edu	37	7	138312093	138312093	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:138312093A>G	ENST00000421622.1	-	8	1030		c.e8+1		SVOPL_ENST00000288513.5_Splice_Site|SVOPL_ENST00000463557.1_Splice_Site|SVOPL_ENST00000419765.3_Splice_Site|SVOPL_ENST00000436657.1_Splice_Site			Q8N434	SVOPL_HUMAN	SVOP-like							integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						AACAGAAAATACCTTGAAGTG	0.433000													17	25					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22174233	22174233	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:22174233C>A	ENST00000374695.3	-	61	8053	c.7974G>T	c.(7972-7974)caG>caT	p.Q2658H	HSPG2_ENST00000430507.1_3'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2658	Ig-like C2-type 12.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGATGATAGCCTGGGGCTGCC	0.642000													6	5					3.59834e-05	3.7043e-05	1	1	0
SPRY3	10251	broad.mit.edu	37	X	155003602	155003602	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:155003602T>C	ENST00000302805.2	+	2	500	c.69T>C	c.(67-69)gcT>gcC	p.A23A		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	23					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane						all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTACTCATGCTAGCAATGACT	0.483000													58	62					0	0	1	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123706393	123706393	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:123706393G>A	ENST00000606320.1	-	5	604	c.398C>T	c.(397-399)gCt>gTt	p.A133V	MPHOSPH9_ENST00000392425.3_5'UTR|MPHOSPH9_ENST00000302349.5_5'UTR|MPHOSPH9_ENST00000541076.2_Missense_Mutation_p.A103V|MPHOSPH9_ENST00000539639.1_5'UTR			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	0					M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		AGCTAAGGAAGCACTACTAGT	0.313000													11	17					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8605825	8605825	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:8605825G>A	ENST00000382480.2	+	4	1008	c.208G>A	c.(208-210)Gtg>Atg	p.V70M	CPZ_ENST00000429646.2_5'UTR|CPZ_ENST00000360986.4_Missense_Mutation_p.V207M|CPZ_ENST00000315782.6_Missense_Mutation_p.V196M	NM_001014448.2	NP_001014448.1	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	207	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CTGCGCCCACGTGGCCAGGAC	0.692000													4	6					0	0	1	0	0
CCM2	83605	broad.mit.edu	37	7	45077977	45077977	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:45077977C>T	ENST00000475551.1	+	2	898	c.138C>T	c.(136-138)cgC>cgT	p.R46R	CCM2_ENST00000258781.6_Silent_p.R52R|CCM2_ENST00000544363.1_Silent_p.R52R|CCM2_ENST00000541586.1_Intron|CCM2_ENST00000474617.1_Silent_p.R46R|CCM2_ENST00000381112.3_Silent_p.R73R|CCM2_ENST00000461377.1_3'UTR			Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2	52					endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding			NS(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						TGCCTGAGCGCGTCGAGCCAG	0.517000													18	23					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61466675	61466675	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61466675C>T	ENST00000424789.2	+	15	2603	c.2599C>T	c.(2599-2601)Cga>Tga	p.R867*	TANC2_ENST00000389520.4_Nonsense_Mutation_p.R867*|AC015923.1_ENST00000431604.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	867							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CTAGGTCAGCCGACTGCTGAT	0.358000													6	21					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47855835	47855835	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:47855835C>T	ENST00000359568.5	+	39	8877	c.8770C>T	c.(8770-8772)Cgt>Tgt	p.R2924C	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2924					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AGAACTGCAGCGTCAGCGTGA	0.532000													44	25					0	0	1	0	0
DKFZP761J1410	0	broad.mit.edu	37	19	11471980	11471980	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11471980C>T	ENST00000251473.5	+	6	855	c.479C>T	c.(478-480)tCc>tTc	p.S160F	DKFZP761J1410_ENST00000591608.1_Missense_Mutation_p.S135F	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					CACTTCCTGTCCGTGTGCCGC	0.667000													13	28					0	0	1	0	0
CHRNA2	0	broad.mit.edu	37	8	27321197	27321197	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:27321197C>T	ENST00000407991.1	-	6	1371	c.763G>A	c.(763-765)Gtc>Atc	p.V255I	CHRNA2_ENST00000240132.2_Missense_Mutation_p.V240I|CHRNA2_ENST00000520933.2_Missense_Mutation_p.V255I	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	255						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GCGTAGGTGACGTCGGGGTAG	0.597000													17	29					0	0	1	0	0
AP1M1	8907	broad.mit.edu	37	19	16345076	16345076	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16345076C>T	ENST00000291439.3	+	11	1689	c.1240C>T	c.(1240-1242)Cag>Tag	p.Q414*	AP1M1_ENST00000590756.1_Nonsense_Mutation_p.Q342*|AP1M1_ENST00000444449.2_Nonsense_Mutation_p.Q426*|AP1M1_ENST00000541844.1_Nonsense_Mutation_p.Q342*|AP1M1_ENST00000429941.2_Nonsense_Mutation_p.Q361*	NM_032493.3	NP_115882.1	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	414	MHD.				cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|prostate(2)	21						TTATATCACGCAGAATGGAGG	0.637000													11	7					0	0	1	0	0
LYAR	55646	broad.mit.edu	37	4	4285407	4285407	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:4285407A>G	ENST00000343470.4	-	3	303	c.63T>C	c.(61-63)caT>caC	p.H21H	LYAR_ENST00000452476.1_Silent_p.H21H	NM_017816.2	NP_060286.1	Q9NX58	LYAR_HUMAN	Ly1 antibody reactive	21				H -> R (in Ref. 3; CAG38579).		nucleolus	metal ion binding|protein binding			endometrium(2)|large_intestine(6)|liver(2)|lung(5)|ovary(1)|prostate(1)	17				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AAACAGACACATGCTTTTCCA	0.363000													15	20					0	0	1	0	0
ZBP1	81030	broad.mit.edu	37	20	56185392	56185392	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:56185392C>T	ENST00000340462.4	-	6	1117	c.837G>A	c.(835-837)tcG>tcA	p.S279S	ZBP1_ENST00000395822.3_Silent_p.S227S|ZBP1_ENST00000371173.3_Silent_p.S302S|ZBP1_ENST00000343535.4_Silent_p.S302S			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	302						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding	p.S302S(1)		large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			TTGCTTCAAACGAAGCTTCTG	0.607000													9	141					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5744496	5744496	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5744496C>T	ENST00000381624.3	+	8	693	c.632C>T	c.(631-633)gCg>gTg	p.A211V	CATSPERD_ENST00000381614.2_5'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	211						integral to membrane											TCACAGGTTGCGATGCTTGTA	0.408000													31	53					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179297286	179297286	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:179297286C>T	ENST00000356834.3	-	16	2731	c.2694G>A	c.(2692-2694)ctG>ctA	p.L898L	TBC1D9B_ENST00000444477.2_Silent_p.L56L|TBC1D9B_ENST00000355235.3_Silent_p.L898L|TBC1D9B_ENST00000519746.1_Silent_p.L74L	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	898	EF-hand.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGAAGTTGATCAGCGAGTCCT	0.602000													43	52					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176857946	176857946	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176857946C>T	ENST00000355472.5	+	2	294	c.126C>T	c.(124-126)tgC>tgT	p.C42C	GRK6_ENST00000355958.5_Silent_p.C42C|GRK6_ENST00000528793.1_Silent_p.C42C|GRK6_ENST00000393576.3_Silent_p.C42C|GRK6_ENST00000507633.1_Silent_p.C42C	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	42	N-terminal.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCAGCCAGTGCGAAGAGCTGC	0.642000													4	10					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179422223	179422223	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179422223C>T	ENST00000589042.1	-	329	87990	c.87766G>A	c.(87766-87768)Gtg>Atg	p.V29256M	TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V20383M|TTN_ENST00000591111.1_Missense_Mutation_p.V27615M|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V20191M|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V26688M|TTN_ENST00000359218.5_Missense_Mutation_p.V20316M|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	27615	Fibronectin type-III 113.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCCAGCCCACAGTGATGCTT	0.428000													28	34					0	0	1	0	0
RBCK1	10616	broad.mit.edu	37	20	409724	409724	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:409724C>T	ENST00000356286.5	+	11	2143	c.1438C>T	c.(1438-1440)Cgc>Tgc	p.R480C	RBCK1_ENST00000382181.2_Missense_Mutation_p.R310C|RBCK1_ENST00000353660.3_Missense_Mutation_p.R438C	NM_031229.2	NP_112506.2	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing 1	480					interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(4)	5		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				CAAGGGCCCACGCTGGGGCCC	0.637000													18	14					0	0	1	0	0
FBXL2	25827	broad.mit.edu	37	3	33415377	33415377	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:33415377C>T	ENST00000484457.1	+	9	712	c.621C>T	c.(619-621)tgC>tgT	p.C207C	FBXL2_ENST00000538892.1_Silent_p.C139C|FBXL2_ENST00000538181.1_Silent_p.C123C|FBXL2_ENST00000507198.1_Silent_p.C139C|FBXL2_ENST00000542085.1_5'UTR|FBXL2_ENST00000446237.3_5'UTR|FBXL2_ENST00000283627.6_3'UTR	NM_012157.3	NP_036289.3	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	207					interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|urinary_tract(1)	15						AGAATTACTGCCATGAGCTTG	0.473000													12	27					0	0	1	0	0
LCA5L	150082	broad.mit.edu	37	21	40781905	40781905	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:40781905C>T	ENST00000358268.2	-	9	1810	c.1282_splice	c.e9+1	p.D428_splice	LCA5L_ENST00000288350.3_Splice_Site_p.D428_splice|LCA5L_ENST00000495240.1_5'UTR|LCA5L_ENST00000380671.2_Splice_Site_p.D428_splice|WRB_ENST00000541890.1_Intron			O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	428										breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	24		Prostate(19;1.2e-06)				TTAAAATTACCTTCATATTTT	0.294000													11	10					0	0	1	0	0
RXRA	6256	broad.mit.edu	37	9	137321010	137321010	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:137321010G>A	ENST00000540193.1	+	6	1599	c.676G>A	c.(676-678)Ggg>Agg	p.G226R	RXRA_ENST00000356384.4_3'UTR|RXRA_ENST00000481739.1_Missense_Mutation_p.G323R			P19793	RXRA_HUMAN	retinoid X receptor, alpha	323	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CGTGAAGGACGGGATCCTCCT	0.687000													8	47					0	0	1	0	0
PBXIP1	57326	broad.mit.edu	37	1	154918557	154918557	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154918557C>T	ENST00000368463.3	-	10	1664	c.1593G>A	c.(1591-1593)aaG>aaA	p.K531K	PBXIP1_ENST00000539880.1_Silent_p.K358K|PBXIP1_ENST00000368465.1_Silent_p.K502K|PBXIP1_ENST00000542459.1_Silent_p.K376K	NM_020524.2	NP_065385.2	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein 1	531					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			breast(1)|kidney(2)|large_intestine(6)|lung(13)|prostate(1)|urinary_tract(1)	24	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCTTGCCCTCCTTCTTGCTCC	0.607000													5	140					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109696269	109696269	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:109696269G>A	ENST00000465301.2	+	3	2670	c.2424G>A	c.(2422-2424)acG>acA	p.T808T	RGAG1_ENST00000540313.1_Silent_p.T808T	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	808										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						AGATAGCCACGCCTCTGAGAT	0.542000													46	6					0	0	1	0	0
KATNB1	10300	broad.mit.edu	37	16	57789088	57789088	+	Missense_Mutation	SNP	C	C	T	rs149569503	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57789088C>T	ENST00000379661.3	+	15	1746	c.1354C>T	c.(1354-1356)Cct>Tct	p.P452S		NM_005886.2	NP_005877.2	Q9BVA0	KTNB1_HUMAN	katanin p80 (WD repeat containing) subunit B 1	452	Interaction with KATNA1 and NDEL1 (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_neural(199;0.223)				CAAGGCTGAGCCTGCCATCAT	0.662000													5	16					0	0	1	0	0
LRRC8E	80131	broad.mit.edu	37	19	7965683	7965683	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7965683C>T	ENST00000306708.6	+	3	2377	c.2276C>T	c.(2275-2277)gCg>gTg	p.A759V	AC010336.1_ENST00000539278.1_5'UTR	NM_001268284.1|NM_001268285.1|NM_025061.4	NP_001255213.1|NP_001255214.1|NP_079337.2	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member E	759						integral to membrane				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(10)	35						CGCTTAGAGGCGCTGCCAGAA	0.637000													17	23					0	0	1	0	0
TOPORS	10210	broad.mit.edu	37	9	32541790	32541790	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:32541790G>A	ENST00000360538.2	-	3	2849	c.2733C>T	c.(2731-2733)gaC>gaT	p.D911D	TOPORS_ENST00000379858.1_Silent_p.D846D	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	911	Interaction with UBE2I.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CACTGTCACTGTCAATGGTAA	0.383000													50	78					0	0	1	0	0
B3GNT9	84752	broad.mit.edu	37	16	67183701	67183701	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67183701C>T	ENST00000449549.3	-	2	1223	c.688G>A	c.(688-690)Gca>Aca	p.A230T		NM_033309.2	NP_171608.2	Q6UX72	B3GN9_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	230					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6						AACACATCTGCGTCGCCCTTA	0.577000													7	18					0	0	1	0	0
ANKS6	203286	broad.mit.edu	37	9	101540677	101540677	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:101540677G>A	ENST00000353234.4	-	7	1445	c.1398C>T	c.(1396-1398)ttC>ttT	p.F466F	ANKS6_ENST00000375018.1_Silent_p.F466F|ANKS6_ENST00000540940.1_Silent_p.F271F|ANKS6_ENST00000375019.2_Silent_p.F165F			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	466										endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				TGAGCTTTCGGAACCGATTGG	0.587000													8	10					0	0	1	0	0
SLC9B1	150159	broad.mit.edu	37	4	103822451	103822451	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:103822451G>T	ENST00000296422.7	-	12	1512	c.1371C>A	c.(1369-1371)gtC>gtA	p.V457V	SLC9B1_ENST00000512651.2_5'UTR|SLC9B1_ENST00000394789.3_Intron	NM_139173.3	NP_631912.2	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	457						integral to membrane	solute:hydrogen antiporter activity										GGGGTGCGGAGACTCTTGCTG	0.423000													8	144					0.000978159	0.000994766	1	1	0
MRPL4	51073	broad.mit.edu	37	19	10369391	10369391	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10369391C>T	ENST00000590669.1	+	8	1013	c.769C>T	c.(769-771)Cgc>Tgc	p.R257C	MRPL4_ENST00000253099.6_Intron|MRPL4_ENST00000393733.2_Intron|CTD-2369P2.5_ENST00000592893.1_RNA|MRPL4_ENST00000307422.5_Intron			Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4	0					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		CCCTAGAGTGCGCATGTGCAG	0.592000													12	39					0	0	1	0	0
CLSTN1	22883	broad.mit.edu	37	1	9811643	9811643	+	Silent	SNP	G	G	A	rs141907444	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:9811643G>A	ENST00000377298.4	-	5	1329	c.537C>T	c.(535-537)taC>taT	p.Y179Y	CLSTN1_ENST00000377288.3_Silent_p.Y179Y|CLSTN1_ENST00000361311.4_Silent_p.Y169Y	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	179	Cadherin 2.				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		AAATGCTGTCGTACTGCTTCC	0.537000													20	43					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47200701	47200701	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:47200701G>A	ENST00000296861.2	-	6	2161	c.1768C>T	c.(1768-1770)Cgc>Tgc	p.R590C		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	590					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			GGGTCCAGGCGTACCTGCCGC	0.532000													27	41					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67265031	67265031	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67265031G>A	ENST00000356404.3	-	13	2127	c.1902C>T	c.(1900-1902)agC>agT	p.S634S	PITPNM1_ENST00000436757.2_Silent_p.S634S|PITPNM1_ENST00000534749.1_Silent_p.S634S	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	634					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						TGGCCATGTCGCTGGGGATGC	0.672000													26	41					0	0	1	0	0
KLHL10	317719	broad.mit.edu	37	17	39994252	39994252	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39994252C>T	ENST00000293303.4	+	1	221	c.68C>T	c.(67-69)gCg>gTg	p.A23V	KLHL10_ENST00000485613.1_3'UTR	NM_152467.3	NP_689680.2	Q6JEL2	KLH10_HUMAN	kelch-like family member 10	23						cytoplasm		p.A23V(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26		Breast(137;0.000162)				AAGATGAGTGCGATGGCCTGT	0.562000													29	40					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156846280	156846280	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156846280G>A	ENST00000368196.3	+	13	1823	c.1703G>A	c.(1702-1704)cGc>cAc	p.R568H	NTRK1_ENST00000392302.2_Missense_Mutation_p.R538H|NTRK1_ENST00000358660.3_Missense_Mutation_p.R571H|NTRK1_ENST00000524377.1_Missense_Mutation_p.R574H	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	574	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CACATCGTGCGCTTCTTCGGC	0.642000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			12	21					0	0	1	0	0
PRSS27	83886	broad.mit.edu	37	16	2764112	2764112	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2764112C>T	ENST00000302641.3	-	4	516	c.462G>A	c.(460-462)acG>acA	p.T154T		NM_031948.3	NP_114154.1	Q9BQR3	PRS27_HUMAN	protease, serine 27	154	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	8						AGTTCATGCCCGTCTCAAAGA	0.622000													21	42					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22167685	22167685	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:22167685C>T	ENST00000374695.3	-	71	9501	c.9422G>A	c.(9421-9423)cGc>cAc	p.R3141H		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3141	Ig-like C2-type 17.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGCAGAGGAGCGGGGCTCCCC	0.667000													9	15					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86198984	86198984	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:86198984C>T	ENST00000361228.3	-	2	1172	c.804G>A	c.(802-804)caG>caA	p.Q268Q		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	268					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GTTCTTCCAGCTGTTCAATTC	0.378000													10	50					0	0	1	0	0
DDX46	9879	broad.mit.edu	37	5	134099638	134099638	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:134099638G>A	ENST00000452510.2	+	2	220	c.62G>A	c.(61-63)cGg>cAg	p.R21Q	DDX46_ENST00000354283.4_Missense_Mutation_p.R21Q	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	21	Arg-rich.				mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCTGGAAGTCGGTCTAGAAGT	0.458000													27	37					0	0	1	0	0
MTHFSD	64779	broad.mit.edu	37	16	86582121	86582121	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:86582121T>C	ENST00000322911.6	-	4	347	c.297A>G	c.(295-297)acA>acG	p.T99T	MTHFSD_ENST00000546093.1_5'UTR|MTHFSD_ENST00000543303.2_Silent_p.T99T|MTHFSD_ENST00000568037.1_5'UTR|MTHFSD_ENST00000360900.6_Silent_p.T100T|MTHFSD_ENST00000381214.5_Silent_p.T100T	NM_001159377.1|NM_022764.2	NP_001152849.1|NP_073601.2	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain containing	100					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding			endometrium(1)|large_intestine(3)|lung(6)|skin(1)	11						CAGGGGGTGGTGTGATCTTAT	0.408000													39	48					0	0	1	0	0
SMPD1	6609	broad.mit.edu	37	11	6415469	6415469	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6415469T>C	ENST00000342245.4	+	6	1696	c.1528T>C	c.(1528-1530)Tct>Cct	p.S510P	SMPD1_ENST00000299397.3_Missense_Mutation_p.S466P|SMPD1_ENST00000527275.1_Missense_Mutation_p.S509P|SMPD1_ENST00000356761.2_Missense_Mutation_p.S454P	NM_000543.4|NM_001007593.2	NP_000534.3|NP_001007594.2	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid lysosomal	508					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(3)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	CTCCGGGAGCTCTCACGTGGT	0.572000													14	21					0	0	1	0	0
EEF1D	1936	broad.mit.edu	37	8	144672148	144672148	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144672148G>A	ENST00000532741.1	-	1	482	c.254C>T	c.(253-255)gCg>gTg	p.A85V	EEF1D_ENST00000317198.6_Intron|EEF1D_ENST00000442189.2_Missense_Mutation_p.A35V|EEF1D_ENST00000395119.3_Intron|EEF1D_ENST00000526838.1_Intron|EEF1D_ENST00000423316.2_Missense_Mutation_p.A35V|EEF1D_ENST00000524624.1_Intron|EEF1D_ENST00000532400.1_Intron|EEF1D_ENST00000419152.2_Intron|EEF1D_ENST00000531621.1_Intron|EEF1D_ENST00000529272.1_Intron|EEF1D_ENST00000528610.1_Intron			P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	33					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			breast(2)|cervix(1)|endometrium(1)|kidney(4)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GGAGGCGGCCGCCTGTGTGGC	0.687000													6	21					0	0	1	0	0
FBXO44	93611	broad.mit.edu	37	1	11721246	11721246	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11721246C>T	ENST00000251546.4	+	5	796	c.559C>T	c.(559-561)Cgg>Tgg	p.R187W	FBXO44_ENST00000376768.1_Missense_Mutation_p.R219W|FBXO44_ENST00000376760.1_Missense_Mutation_p.R187W|FBXO44_ENST00000251547.5_Silent_p.G228G|FBXO44_ENST00000376770.1_Silent_p.G228G|FBXO44_ENST00000376762.4_Missense_Mutation_p.R187W	NM_183412.2	NP_904319.1	Q9H4M3	FBX44_HUMAN	F-box protein 44	0	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		TTCAGCACGGCGGCGTGGACA	0.662000													19	32					0	0	1	0	0
KIAA0895L	653319	broad.mit.edu	37	16	67210861	67210861	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67210861C>T	ENST00000290881.7	-	8	2195	c.1269G>A	c.(1267-1269)gtG>gtA	p.V423V	KIAA0895L_ENST00000561679.1_Silent_p.V268V|KIAA0895L_ENST00000561621.1_3'UTR|KIAA0895L_ENST00000563902.1_Silent_p.V423V|KIAA0895L_ENST00000563831.2_5'UTR			Q68EN5	K895L_HUMAN	KIAA0895-like	423										breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|skin(1)	17						GCAGGTGGTCCACATCCTCAT	0.622000													21	35					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233759598	233759598	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:233759598G>A	ENST00000264051.3	-	6	1135	c.857C>T	c.(856-858)gCg>gTg	p.A286V	NGEF_ENST00000409079.1_Missense_Mutation_p.A194V|NGEF_ENST00000539537.1_Missense_Mutation_p.A9V|NGEF_ENST00000373552.4_Missense_Mutation_p.A194V	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	286	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GTAGTAGGACGCCTCGGAAGT	0.582000													31	46					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42795296	42795296	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42795296G>A	ENST00000572681.2	+	11	5171	c.5103G>A	c.(5101-5103)gcG>gcA	p.A1701A	CIC_ENST00000160740.3_Silent_p.A792A|CIC_ENST00000575354.2_Silent_p.A792A			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	792					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GGACCACTGCGGGCTCAGGAG	0.682000			"""Mis, F, S"""		oligodendroglioma								9	17					0	0	1	0	0
LONP1	9361	broad.mit.edu	37	19	5707726	5707726	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5707726G>A	ENST00000360614.3	-	6	1201	c.1044C>T	c.(1042-1044)gaC>gaT	p.D348D	LONP1_ENST00000585374.1_Silent_p.D234D|LONP1_ENST00000593119.1_Silent_p.D284D|LONP1_ENST00000590729.1_Silent_p.D218D|LONP1_ENST00000540670.2_Silent_p.D152D	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	348	Lon.				cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CTTCCAGGACGTCCTGCAGCT	0.682000													31	42					0	0	1	0	0
ULBP2	80328	broad.mit.edu	37	6	150267638	150267638	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:150267638G>A	ENST00000367351.3	+	3	553	c.480G>A	c.(478-480)acG>acA	p.T160T		NM_025217.2	NP_079493.1	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2	160	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		TGTGGACAACGGTTCATCCTG	0.478000													52	87					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170062058	170062058	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:170062058C>T	ENST00000263816.3	-	41	7931	c.7646G>A	c.(7645-7647)aGt>aAt	p.S2549N		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2549					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CATGACCAGACTGCTGTTCAC	0.512000													28	25					0	0	1	0	0
LLGL1	3996	broad.mit.edu	37	17	18141473	18141473	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18141473G>A	ENST00000316843.4	+	15	2093	c.1997G>A	c.(1996-1998)cGc>cAc	p.R666H		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	666					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					TCTTTCCGGCGCATTCGCAAG	0.617000													8	24					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53908404	53908404	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:53908404C>A	ENST00000396328.1	-	15	2238	c.1999G>T	c.(1999-2001)Gtc>Ttc	p.V667F	WDR72_ENST00000557913.1_Missense_Mutation_p.V664F|WDR72_ENST00000360509.5_Missense_Mutation_p.V667F|WDR72_ENST00000559418.1_Missense_Mutation_p.V677F	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	667										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		ACAGGCAAGACATTAAAAGGT	0.343000													24	36					8.58068e-18	9.45481e-18	1	1	0
MFF	56947	broad.mit.edu	37	2	228205038	228205038	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:228205038C>T	ENST00000353339.3	+	6	901	c.460C>T	c.(460-462)Cgg>Tgg	p.R154W	MFF_ENST00000392059.1_Missense_Mutation_p.R154W|MFF_ENST00000354503.6_Missense_Mutation_p.R128W|MFF_ENST00000409616.1_Missense_Mutation_p.R128W|MFF_ENST00000476924.1_3'UTR|MFF_ENST00000349901.7_Missense_Mutation_p.R128W|MFF_ENST00000304593.9_Missense_Mutation_p.R128W|MFF_ENST00000409565.1_Missense_Mutation_p.R128W|MFF_ENST00000524634.1_5'UTR|MFF_ENST00000337110.7_Missense_Mutation_p.R128W	NM_001277061.1	NP_001263990.1	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	154						integral to membrane|mitochondrial outer membrane				breast(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(4)|stomach(2)	21						AAAAAGAGAGCGGTCTATGAG	0.408000													7	14					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9912932	9912932	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:9912932C>T	ENST00000380913.3	+	9	4653	c.4563C>T	c.(4561-4563)gaC>gaT	p.D1521D	SHROOM2_ENST00000418909.2_Silent_p.D356D	NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	1521	ASD2.				apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				ATTTGGACGACGGCGCTTCTC	0.557000													3	1					0	0	1	0	0
MTMR11	10903	broad.mit.edu	37	1	149902422	149902422	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:149902422T>C	ENST00000439741.2	-	15	1732	c.1482A>G	c.(1480-1482)caA>caG	p.Q494Q	MTMR11_ENST00000369140.3_Silent_p.Q422Q|MTMR11_ENST00000361405.6_3'UTR|MTMR11_ENST00000492824.1_5'UTR|MTMR11_ENST00000406732.3_3'UTR	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	494	Myotubularin phosphatase.						phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GGGTGTAGACTTGTGTATAGG	0.453000													31	51					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7674414	7674414	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7674414C>A	ENST00000299492.4	+	24	2984	c.2596C>A	c.(2596-2598)Ctg>Atg	p.L866M	PPFIBP2_ENST00000530181.1_Missense_Mutation_p.L723M|PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000533792.1_Missense_Mutation_p.L708M|PPFIBP2_ENST00000528883.1_Missense_Mutation_p.L754M	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	866					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TGCCCCTGAACTGGATGGGCT	0.572000													20	33					1.01871e-10	1.09092e-10	1	1	0
KIF2C	11004	broad.mit.edu	37	1	45232618	45232618	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:45232618C>T	ENST00000372217.1	+	19	2281	c.1930C>T	c.(1930-1932)Cga>Tga	p.R644*	KIF2C_ENST00000372222.3_Nonsense_Mutation_p.R585*|KIF2C_ENST00000372224.4_Nonsense_Mutation_p.R698*|KIF2C_ENST00000372218.4_Nonsense_Mutation_p.R657*|RP11-269F19.2_ENST00000428791.1_RNA			Q99661	KIF2C_HUMAN	kinesin family member 2C	698					blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(1)|skin(1)|urinary_tract(1)	34	Acute lymphoblastic leukemia(166;0.155)					CTCAGCCCTGCGAGGTGGGTG	0.602000													32	57					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121292281	121292281	+	Missense_Mutation	SNP	G	G	A	rs115901568	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:121292281G>A	ENST00000297848.3	+	29	3859	c.3589G>A	c.(3589-3591)Gcc>Acc	p.A1197T	COL14A1_ENST00000309791.4_Missense_Mutation_p.A1197T|COL14A1_ENST00000247781.3_Missense_Mutation_p.A1102T	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1197	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGACTTTGACGCCTTTAAGAA	0.423000													29	53					0	0	1	0	0
PLOD1	5351	broad.mit.edu	37	1	12017931	12017931	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12017931G>A	ENST00000196061.4	+	8	801	c.774G>A	c.(772-774)ccG>ccA	p.P258P	PLOD1_ENST00000485046.1_3'UTR|PLOD1_ENST00000376369.3_Silent_p.P305P	NM_000302.3	NP_000293.2	Q02809	PLOD1_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	258					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	ACTACATCCCGCGCTTCTGGA	0.627000													41	66					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72047551	72047551	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:72047551G>A	ENST00000265381.4	-	12	2565	c.2343C>T	c.(2341-2343)ggC>ggT	p.G781G		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	781	PDZ 2.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						CCACACGGACGCCTCCTCTCT	0.587000													15	20					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149212721	149212721	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149212721C>T	ENST00000309241.5	+	5	1117	c.1085C>T	c.(1084-1086)gCc>gTc	p.A362V	PPARGC1B_ENST00000403750.1_Missense_Mutation_p.A298V|PPARGC1B_ENST00000360453.4_Missense_Mutation_p.A323V|PPARGC1B_ENST00000394320.3_Missense_Mutation_p.A362V	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	362					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TACCGTCTGGCCACGCCTGTT	0.617000													21	24					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3417578	3417578	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:3417578C>T	ENST00000356575.4	-	20	2753	c.2527G>A	c.(2527-2529)Gga>Aga	p.G843R	MEGF6_ENST00000294599.4_Missense_Mutation_p.G738R	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	843	EGF-like 14.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CTGCAGTGTCCGGTGGCTGGG	0.637000													18	23					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7254672	7254672	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:7254672G>A	ENST00000545280.1	-	2	99	c.83C>T	c.(82-84)tCg>tTg	p.S28L	C1RL_ENST00000545337.1_Silent_p.V104V|C1RL_ENST00000544702.1_Silent_p.V104V|C1RL_ENST00000266542.4_Silent_p.V104V			Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	0					complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GATCCGAACCGACGAATGAGA	0.602000													25	52					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52567466	52567466	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:52567466C>T	ENST00000313234.5	-	5	846	c.749G>A	c.(748-750)gGc>gAc	p.G250D	KRT80_ENST00000394815.2_Missense_Mutation_p.G250D	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	250	Linker 12.|Rod.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		CTCCACGATGCCGCTCAGGTC	0.652000													20	44					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155278424	155278424	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:155278424G>C	ENST00000357232.3	-	6	746	c.747C>G	c.(745-747)gaC>gaG	p.D249E	DCHS2_ENST00000339452.1_Intron	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	249	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ttacttccttgtctgctgaaa	0.438000													37	64					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102883	22102883	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22102883T>C	ENST00000542433.1	-	1	213	c.116A>G	c.(115-117)tAc>tGc	p.Y39C		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		AGTGAGGATGTAAATGATGAA	0.517000													19	20					0	0	1	0	0
RBM10	8241	broad.mit.edu	37	X	47030610	47030610	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:47030610A>G	ENST00000377604.3	+	4	1127	c.385A>G	c.(385-387)Aac>Gac	p.N129D	RBM10_ENST00000345781.6_Intron|RBM10_ENST00000329236.7_Intron|RBM10_ENST00000468791.1_3'UTR	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	129	RRM 1.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						gaaggCCAGTAACATCGTCAT	0.652000													7	1					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145011407	145011407	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145011407G>A	ENST00000322810.4	-	4	848	c.679C>T	c.(679-681)Cgg>Tgg	p.R227W	PLEC_ENST00000436759.2_Missense_Mutation_p.R117W|PLEC_ENST00000398774.2_Missense_Mutation_p.R58W|PLEC_ENST00000356346.3_Missense_Mutation_p.R76W|PLEC_ENST00000357649.2_Missense_Mutation_p.R94W|PLEC_ENST00000354589.3_Missense_Mutation_p.R90W|PLEC_ENST00000527096.1_Missense_Mutation_p.R117W|PLEC_ENST00000345136.3_Missense_Mutation_p.R90W|PLEC_ENST00000354958.2_Missense_Mutation_p.R68W	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	227	Actin-binding.|CH 1.|Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CCCTTCTCCCGGGGCTGTGGG	0.677000													10	17					0	0	1	0	0
PCSK9	255738	broad.mit.edu	37	1	55521752	55521752	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55521752G>A	ENST00000302118.5	+	6	1176	c.886G>A	c.(886-888)Gtc>Atc	p.V296I	PCSK9_ENST00000543384.1_Missense_Mutation_p.V96I|PCSK9_ENST00000490692.1_3'UTR	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	296	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						GTACAGCCGCGTCCTCAACGC	0.677000													4	7					0	0	1	0	0
QPCTL	54814	broad.mit.edu	37	19	46205061	46205061	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46205061C>T	ENST00000012049.5	+	6	1113	c.892C>T	c.(892-894)Cgt>Tgt	p.R298C	QPCTL_ENST00000366382.4_Missense_Mutation_p.R204C	NM_017659.3	NP_060129.2	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like	298					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|lung(5)|skin(1)|stomach(1)	11		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		TCCAGAGAAGCGTCTGCACCG	0.552000													30	61					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6245335	6245335	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6245335C>T	ENST00000265978.4	-	3	640	c.282G>A	c.(280-282)ggG>ggA	p.G94G	FAM160A2_ENST00000449352.2_Silent_p.G94G|FAM160A2_ENST00000524416.1_Silent_p.G94G	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	94					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCAGCAGGGGCCCAGGGCCTG	0.627000													9	12					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56465875	56465875	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56465875C>T	ENST00000291971.3	+	3	522	c.451C>T	c.(451-453)Cgg>Tgg	p.R151W	NLRP8_ENST00000590542.1_Missense_Mutation_p.R151W	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	151						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AGGTAAAATACGGCGGTATAA	0.408000													37	35					0	0	1	0	0
TTC24	164118	broad.mit.edu	37	1	156555582	156555582	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156555582T>C	ENST00000368236.3	+	9	1570	c.1534T>C	c.(1534-1536)Tgc>Cgc	p.C512R	TTC24_ENST00000495690.1_3'UTR|TTC24_ENST00000368237.3_Missense_Mutation_p.C512R	NM_001105669.2	NP_001099139.2	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	512							binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|prostate(1)	20	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCACACGCCCTGCAGAGGGAC	0.522000													18	25					0	0	1	0	0
ACTR3B	57180	broad.mit.edu	37	7	152522194	152522194	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:152522194G>A	ENST00000256001.8	+	9	1072	c.938G>A	c.(937-939)cGc>cAc	p.R313H	ACTR3B_ENST00000377776.3_Missense_Mutation_p.R313H|ACTR3B_ENST00000537264.1_Missense_Mutation_p.R225H|ACTR3B_ENST00000397282.2_Missense_Mutation_p.R225H	NM_020445.5	NP_065178.1	Q9P1U1	ARP3B_HUMAN	ARP3 actin-related protein 3 homolog B (yeast)	313					regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding			breast(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	13		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)		GATGTGCGGCGCCCGCTGTAT	0.413000													9	27					0	0	1	0	0
MKL1	57591	broad.mit.edu	37	22	40827479	40827479	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:40827479C>A	ENST00000396617.3	-	6	659	c.69G>T	c.(67-69)gaG>gaT	p.E23D	MKL1_ENST00000407029.1_Missense_Mutation_p.E23D|MKL1_ENST00000355630.3_Missense_Mutation_p.E23D|MKL1_ENST00000402630.1_Missense_Mutation_p.E23D|MKL1_ENST00000402042.1_Missense_Mutation_p.E23D			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	23	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						TGAGATAGTCCTCTGTCTACA	0.488000			T	RBM15	acute megakaryocytic leukemia								45	64					1.57945e-13	1.71745e-13	1	1	0
COG7	91949	broad.mit.edu	37	16	23400346	23400346	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:23400346G>A	ENST00000307149.5	-	17	2393	c.2208C>T	c.(2206-2208)atC>atT	p.I736I		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	736					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		GTAGCGTCACGATGTGCTGGA	0.617000													14	23					0	0	1	0	0
TRIM25	7706	broad.mit.edu	37	17	54969233	54969233	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:54969233G>A	ENST00000316881.4	-	9	1770	c.1721C>T	c.(1720-1722)gCc>gTc	p.A574V	TRIM25_ENST00000537230.1_Missense_Mutation_p.A574V	NM_005082.4	NP_005073.2	Q14258	TRI25_HUMAN	tripartite motif containing 25	574	B30.2/SPRY.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Breast(9;6.15e-08)					CACCCGCGTGGCCTTGGTGGA	0.572000													10	13					0	0	1	0	0
TMC6	11322	broad.mit.edu	37	17	76120763	76120763	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:76120763C>T	ENST00000590602.1	-	8	892	c.733G>A	c.(733-735)Gtg>Atg	p.V245M	TMC6_ENST00000306591.7_Missense_Mutation_p.V245M|TMC6_ENST00000322914.3_Missense_Mutation_p.V245M|TMC6_ENST00000589553.1_Missense_Mutation_p.V18M|TMC6_ENST00000392467.3_Missense_Mutation_p.V245M|TMC6_ENST00000322933.4_De_novo_Start_InFrame			Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	245						endoplasmic reticulum membrane|integral to membrane				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	14			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TAGGAGAGCACGCTGGAGCCG	0.662000													4	9					0	0	1	0	0
PAF1	54623	broad.mit.edu	37	19	39876748	39876748	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39876748G>A	ENST00000595564.1	-	13	1554	c.1265C>T	c.(1264-1266)gCc>gTc	p.A422V	PAF1_ENST00000221266.7_Missense_Mutation_p.A399V|PAF1_ENST00000221265.3_Silent_p.S493S	NM_001256826.1	NP_001243755.1	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0	Glu-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|urinary_tract(2)	17	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TGTGGCTCCGGCTCCGCTGGC	0.627000													5	60					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984637	41984637	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:41984637G>A	ENST00000333141.5	+	1	925	c.828G>A	c.(826-828)gtG>gtA	p.V276V		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	276										breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						TGACCTCTGTGCAAATCCTCC	0.527000													6	76					0	0	1	0	0
ATF5	22809	broad.mit.edu	37	19	50434121	50434121	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50434121C>T	ENST00000423777.2	+	2	391	c.14C>T	c.(13-15)gCg>gTg	p.A5V	ATF5_ENST00000600336.1_Missense_Mutation_p.A5V|CTC-326K19.6_ENST00000451973.1_Intron|ATF5_ENST00000595125.1_Missense_Mutation_p.A5V	NM_001193646.1	NP_001180575.1	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5	5					regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			NS(1)|endometrium(2)|large_intestine(1)|skin(3)	7		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		TCACTCCTGGCGACCCTGGGG	0.667000													5	10					0	0	1	0	0
ATP5G1	516	broad.mit.edu	37	17	46972665	46972665	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:46972665G>A	ENST00000393366.2	+	4	368	c.265G>A	c.(265-267)Gtg>Atg	p.V89M	RP11-463M16.4_ENST00000508743.1_RNA|ATP5G1_ENST00000506855.1_Missense_Mutation_p.V63M|ATP5G1_ENST00000503641.1_Missense_Mutation_p.V80M|ATP5G1_ENST00000513781.1_3'UTR|ATP5G1_ENST00000514808.1_Missense_Mutation_p.V89M|ATP5G1_ENST00000355938.5_Missense_Mutation_p.V89M	NM_005175.2	NP_005166.1	P05496	AT5G1_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)	89					ATP hydrolysis coupled proton transport|mitochondrial ATP synthesis coupled proton transport|respiratory electron transport chain	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding			liver(1)|lung(1)	2						CATTGGAACCGTGTTTGGCAG	0.552000													16	31					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50792779	50792779	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50792779G>A	ENST00000440075.2	+	35	4886	c.4839G>A	c.(4837-4839)ctG>ctA	p.L1613L	MYH14_ENST00000425460.1_Silent_p.L1580L|MYH14_ENST00000376970.2_Silent_p.L1605L|MYH14_ENST00000262269.8_Silent_p.L1613L|MYH14_ENST00000601313.1_Silent_p.L1613L|MYH14_ENST00000598205.1_Silent_p.L1580L|MYH14_ENST00000596571.1_Silent_p.L1572L			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1572					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		AGGATGAGCTGACAGCGGCCG	0.607000													8	16					0	0	1	0	0
PTK7	0	broad.mit.edu	37	6	43109739	43109739	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43109739C>T	ENST00000230419.4	+	12	2060	c.1839C>T	c.(1837-1839)tgC>tgT	p.C613C	PTK7_ENST00000352931.2_Silent_p.C613C|PTK7_ENST00000345201.2_Silent_p.C573C|PTK7_ENST00000349241.2_Silent_p.C483C|PTK7_ENST00000481273.1_Silent_p.C621C	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	613	Ig-like C2-type 7.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			TACTGCAGTGCGAGGCCCAGG	0.602000													19	19					0	0	1	0	0
MLLT1	4298	broad.mit.edu	37	19	6270767	6270767	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6270767T>C	ENST00000252674.7	-	2	179	c.16A>G	c.(16-18)Acc>Gcc	p.T6A		NM_005934.3	NP_005925.2	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	6					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|skin(2)	17						ACCTGGACGGTGCACTGGAGG	0.612000			T	MLL	AL						OREG0025198	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	15					0	0	1	0	0
TRIM68	55128	broad.mit.edu	37	11	4622021	4622021	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:4622021G>A	ENST00000300747.5	-	7	1232	c.943C>T	c.(943-945)Cgt>Tgt	p.R315C		NM_018073.6	NP_060543.5	Q6AZZ1	TRI68_HUMAN	tripartite motif containing 68	315	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		ACGATGAGACGGGAGTAAGCA	0.493000													18	19					0	0	1	0	0
FAM178A	0	broad.mit.edu	37	10	102709874	102709874	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:102709874T>C	ENST00000238961.3	+	16	3310	c.3162T>C	c.(3160-3162)tcT>tcC	p.S1054S	FAM178A_ENST00000370269.3_Silent_p.S1054S	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	1054																	TGAAGCCTTCTGATTTGTTAA	0.358000													56	68					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123900355	123900355	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:123900355C>T	ENST00000431524.1	+	1	59	c.26C>T	c.(25-27)gCg>gTg	p.A9V		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTACTGACAGCGTTCATCCTC	0.542000													33	58					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225796306	225796306	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:225796306G>T	ENST00000409592.3	-	2	298	c.185C>A	c.(184-186)cCt>cAt	p.P62H	DOCK10_ENST00000258390.7_Missense_Mutation_p.P68H|DOCK10_ENST00000474102.1_5'UTR			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	68							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		ATCTTGAAGAGGATCATTCCG	0.418000													6	18					3.59834e-05	3.7043e-05	1	1	0
SPAG5	10615	broad.mit.edu	37	17	26912639	26912639	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26912639G>A	ENST00000321765.5	-	8	2105	c.1773C>T	c.(1771-1773)caC>caT	p.H591H		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	591					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					GCTGGCTGGCGTGTGCACAGA	0.542000													63	108					0	0	1	0	0
STAMBP	10617	broad.mit.edu	37	2	74086401	74086401	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74086401G>A	ENST00000394070.2	+	8	1529	c.1026G>A	c.(1024-1026)gcG>gcA	p.A342A	STAMBP_ENST00000339566.3_Silent_p.A342A|STAMBP_ENST00000486458.1_3'UTR|STAMBP_ENST00000394073.1_Silent_p.A342A|STAMBP_ENST00000409707.1_Silent_p.A342A	NM_213622.2	NP_998787.1	O95630	STABP_HUMAN	STAM binding protein	342	MPN.				JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	18						CACAGACCGCGTTTCTCTCCA	0.493000													93	122					0	0	1	0	0
SPI1	6688	broad.mit.edu	37	11	47376808	47376808	+	Silent	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:47376808G>C	ENST00000378538.3	-	5	1005	c.783C>G	c.(781-783)ggC>ggG	p.G261G	SPI1_ENST00000227163.4_Silent_p.G262G|SPI1_ENST00000533030.1_3'UTR	NM_001080547.1|NM_003120.2	NP_001074016.1|NP_003111.2	P17947	SPI1_HUMAN	spleen focus forming virus (SFFV) proviral integration oncogene	261					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of erythrocyte differentiation	nucleus	protein binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(4)|ovary(1)	8				Lung(87;0.0967)		GCTCGGCCAGGCCCCCGCGGC	0.736000													2	3					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68995533	68995533	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:68995533C>T	ENST00000356291.2	-	1	65	c.6G>A	c.(4-6)atG>atA	p.M2I		NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	2					proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						CTTACGCGTACATCATGAACC	0.463000													9	28					0	0	1	0	0
KRT39	390792	broad.mit.edu	37	17	39116560	39116560	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39116560C>T	ENST00000355612.2	-	6	1225	c.1190G>A	c.(1189-1191)cGc>cAc	p.R397H	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	397	Coil 2.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				CAGAAGGCTGCGGTATGTGGT	0.478000													18	126					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46628442	46628442	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:46628442C>A	ENST00000470495.1	-	2	1997	c.550G>T	c.(550-552)Ggg>Tgg	p.G184W	HOXB3_ENST00000490677.1_Missense_Mutation_p.G50W|HOXB-AS1_ENST00000435312.1_RNA|HOXB3_ENST00000498678.1_Missense_Mutation_p.G184W|HOXB3_ENST00000311626.4_Missense_Mutation_p.G184W|HOXB3_ENST00000476342.1_Missense_Mutation_p.G184W|HOXB3_ENST00000489475.1_Missense_Mutation_p.G111W|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Missense_Mutation_p.G52W|HOXB3_ENST00000472863.1_Missense_Mutation_p.G111W|HOXB-AS1_ENST00000502764.2_RNA|HOXB3_ENST00000485909.2_Missense_Mutation_p.G52W			P14651	HXB3_HUMAN	homeobox B3	184					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						GCCGCCGACCCCGGGGGGCTC	0.756000													12	54					7.03913e-09	7.44699e-09	1	1	0
ZNF777	27153	broad.mit.edu	37	7	149129128	149129128	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149129128C>T	ENST00000247930.4	-	6	2558	c.2235G>A	c.(2233-2235)tcG>tcA	p.S745S		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	745					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GCCGCTCGCGCGAGTGCACGC	0.672000													31	42					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34824188	34824188	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:34824188T>C	ENST00000192788.5	+	10	1462		c.e10+2		UHRF1BP1_ENST00000452449.2_Splice_Site	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						GAAAAGCAGGTGGGTTATGAG	0.453000													20	29					0	0	1	0	0
NFKBIB	4793	broad.mit.edu	37	19	39399383	39399383	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39399383G>A	ENST00000313582.5	+	6	1016	c.982G>A	c.(982-984)Gac>Aac	p.D328N	NFKBIB_ENST00000392079.3_3'UTR	NM_002503.4	NP_002494.2	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	328					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	8	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			TGAATACGACGACATTGTGGT	0.587000													11	28					0	0	1	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99654769	99654769	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99654769G>A	ENST00000292450.4	+	2	304	c.140G>A	c.(139-141)cGc>cAc	p.R47H	ZSCAN21_ENST00000543588.1_Missense_Mutation_p.R47H|ZSCAN21_ENST00000456748.2_Missense_Mutation_p.R47H|ZSCAN21_ENST00000477297.1_3'UTR	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	47	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TTCCGCCAGCGCTTCAGGCAG	0.597000													34	52					0	0	1	0	0
PUS10	150962	broad.mit.edu	37	2	61175289	61175289	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:61175289C>T	ENST00000316752.6	-	16	1601	c.1340G>A	c.(1339-1341)cGc>cAc	p.R447H	PUS10_ENST00000407787.1_Missense_Mutation_p.R447H	NM_144709.2	NP_653310.2	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	447	RNA binding thumb loop (Potential).				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)	22			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			GTGAAGGACGCGCAAAGGTGT	0.527000													19	50					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28530244	28530244	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:28530244G>A	ENST00000401766.2	-	13	2276	c.1764C>T	c.(1762-1764)tgC>tgT	p.C588C	SLC6A4_ENST00000261707.3_Silent_p.C588C			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	588					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	ATGTGGGGATGCAAATGAAAG	0.398000													22	79					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138732578	138732578	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:138732578G>A	ENST00000242351.5	-	13	2787	c.2471C>T	c.(2470-2472)gCc>gTc	p.A824V	ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.A946V	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	824	PARP catalytic.				response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						GGAATAGATGGCATCTTTTGC	0.318000													23	41					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123514535	123514535	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:123514535T>C	ENST00000422452.2	-	32	8113	c.8050A>G	c.(8050-8052)Aca>Gca	p.T2684A	STAG2_ENST00000469481.1_Intron|TENM1_ENST00000371130.3_Missense_Mutation_p.T2677A	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TCCCCTTCTGTCCATGCCCTA	0.512000													56	18					0	0	1	0	0
ECT2L	345930	broad.mit.edu	37	6	139183810	139183810	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:139183810G>A	ENST00000423192.1	+	10	1406	c.1245G>A	c.(1243-1245)acG>acA	p.T415T	ECT2L_ENST00000367682.2_Silent_p.T415T|ECT2L_ENST00000495970.1_3'UTR|ECT2L_ENST00000541398.1_Silent_p.T346T			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	415					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						TAACTGGCACGTTCTTTACGG	0.468000			"""N, Splice, Mis"""		ETP ALL								37	45					0	0	1	0	0
HYAL2	8692	broad.mit.edu	37	3	50357818	50357818	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50357818G>A	ENST00000447092.1	-	1	2395	c.103C>T	c.(103-105)Ccc>Tcc	p.P35S	TUSC2_ENST00000462137.1_5'UTR|HYAL2_ENST00000395139.3_Missense_Mutation_p.P35S|HYAL2_ENST00000357750.4_Missense_Mutation_p.P35S|HYAL2_ENST00000442581.1_Missense_Mutation_p.P35S			Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2	35						anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			breast(1)|endometrium(2)|kidney(1)|ovary(1)|prostate(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	ACCACAAAGGGCCGGCCAGTG	0.637000													13	12					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180905307	180905307	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:180905307G>A	ENST00000367588.4	+	5	2317	c.2262G>A	c.(2260-2262)acG>acA	p.T754T	KIAA1614_ENST00000367587.1_Silent_p.T375T	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	754										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						CCCCCATGACGCCTGAATCAT	0.622000													4	21					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907837	77907837	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:77907837C>T	ENST00000355300.6	-	2	586	c.412G>A	c.(412-414)Gtc>Atc	p.V138I	LINGO1_ENST00000561030.1_Missense_Mutation_p.V132I	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	138					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						CCAGTGAAGACGCCTAGCGGG	0.572000													18	30					0	0	1	0	0
SASH1	23328	broad.mit.edu	37	6	148865629	148865629	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:148865629G>A	ENST00000367467.3	+	18	3498	c.3023G>A	c.(3022-3024)aGt>aAt	p.S1008N		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	1008	Pro-rich.						protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		ATGGGCCCCAGTGGGGCCCTC	0.637000													15	34					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2987233	2987233	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2987233G>T	ENST00000396946.4	-	3	599	c.196C>A	c.(196-198)Ctg>Atg	p.L66M		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	66	CARD.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity	p.L59L(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTGGATGGCAGCATAGGGGCA	0.542000			Mis		DLBCL								30	52					1.45844e-13	1.58619e-13	1	1	0
PLEKHG1	57480	broad.mit.edu	37	6	151153216	151153216	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:151153216C>T	ENST00000367328.1	+	16	3281	c.2969C>T	c.(2968-2970)gCg>gTg	p.A990V	PLEKHG1_ENST00000358517.2_Missense_Mutation_p.A990V	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	990					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		ATTAAGAAGGCGAATCAACTT	0.498000													5	102					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53572740	53572740	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53572740G>T	ENST00000601421.1	-	3	1815	c.939C>A	c.(937-939)gcC>gcA	p.A313A	ZNF160_ENST00000418871.1_Silent_p.A349A|ZNF160_ENST00000429604.1_Silent_p.A349A|ZNF160_ENST00000599056.1_Silent_p.A349A			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	349					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		GTCCTCTAAAGGCTTTTCCAC	0.403000													26	46					4.59853e-10	4.90296e-10	1	1	0
KIAA0319	9856	broad.mit.edu	37	6	24559300	24559300	+	Missense_Mutation	SNP	C	C	T	rs141240086	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:24559300C>T	ENST00000535378.1	-	18	3290	c.2648G>A	c.(2647-2649)cGg>cAg	p.R883Q	KIAA0319_ENST00000378214.3_Missense_Mutation_p.R892Q|KIAA0319_ENST00000430948.2_Missense_Mutation_p.R847Q|KIAA0319_ENST00000543707.1_Missense_Mutation_p.R892Q|KIAA0319_ENST00000537886.1_Missense_Mutation_p.R892Q	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	892					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						CTTTGAGAGCCGCATGTGCAG	0.478000													15	14					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8668659	8668659	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8668659C>T	ENST00000270328.4	-	4	811	c.545G>A	c.(544-546)cGt>cAt	p.R182H	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.R182H|ADAMTS10_ENST00000596709.1_5'UTR			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	182					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.R182H(14)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						CAGAGAGGAACGCTTGTACAC	0.587000													12	19					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150742338	150742338	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150742338G>A	ENST00000358849.4	+	16	2152	c.2059G>A	c.(2059-2061)Gcc>Acc	p.A687T	ABCB8_ENST00000297504.6_Missense_Mutation_p.A704T|ABCB8_ENST00000356058.4_3'UTR|ABCB8_ENST00000498578.1_Missense_Mutation_p.A662T|ABCB8_ENST00000542328.1_Missense_Mutation_p.A599T	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	704	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGGGCTATACGCCGAGCTCAT	0.632000													18	30					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48615753	48615753	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48615753C>T	ENST00000328333.8	-	64	5640		c.e64+1		COL7A1_ENST00000454817.1_Splice_Site	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1						cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GACACACTCACGTTTTTTCCA	0.562000													13	13					0	0	1	0	0
CELA2B	51032	broad.mit.edu	37	1	15813898	15813898	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:15813898C>T	ENST00000375910.3	+	7	783	c.758C>T	c.(757-759)aCg>aTg	p.T253M		NM_015849.2	NP_056933.2	P08218	CEL2B_HUMAN	chymotrypsin-like elastase family, member 2B	253	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)	8						TCCATCTTCACGCGGGTCTCC	0.597000													39	56					0	0	1	0	0
IGSF9	57549	broad.mit.edu	37	1	159906633	159906633	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:159906633G>T	ENST00000368094.1	-	5	663	c.466C>A	c.(466-468)Ctg>Atg	p.L156M	IGSF9_ENST00000361509.3_Missense_Mutation_p.L156M	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	156	Ig-like 2.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			ACACAACGCAGGGTCACAGGC	0.642000											OREG0013921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	28					0.00116845	0.0011864	1	1	0
CLEC18B	497190	broad.mit.edu	37	16	74444924	74444924	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:74444924G>A	ENST00000339953.5	-	9	1114	c.993C>T	c.(991-993)ggC>ggT	p.G331G		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	331	C-type lectin.					extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						CCAGCACCCCGCCTTTCCTCT	0.617000													9	78					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49420496	49420496	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49420496G>A	ENST00000301067.7	-	48	15252	c.15253C>T	c.(15253-15255)Cac>Tac	p.H5085Y		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		AGTCCTCGGTGCAGGGCAACC	0.597000													19	15					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50820020	50820020	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:50820020C>T	ENST00000374115.3	+	1	1674	c.1234C>T	c.(1234-1236)Cgc>Tgc	p.R412C	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	412					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						GGTGGACGTGCGCCATGTCTC	0.617000													10	17					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118950454	118950454	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:118950454C>A	ENST00000328252.3	+	2	1806	c.1437C>A	c.(1435-1437)acC>acA	p.T479T	PAPPA_ENST00000534838.1_5'UTR	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	479	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						CTGAAATCACCAATGTCACTC	0.488000													14	27					4.7546e-09	5.0353e-09	1	1	0
QRICH2	84074	broad.mit.edu	37	17	74288956	74288956	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74288956G>A	ENST00000262765.5	-	4	1533	c.1354C>T	c.(1354-1356)Cgt>Tgt	p.R452C		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	452	Gln-rich.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						accaaaccacgctgatctgca	0.552000													17	28					0	0	1	0	0
HAVCR2	84868	broad.mit.edu	37	5	156514161	156514161	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:156514161G>A	ENST00000307851.4	-	7	1588	c.858C>T	c.(856-858)agC>agT	p.S286S	HAVCR2_ENST00000522593.1_Silent_p.S258S	NM_032782.4	NP_116171.3	Q8TDQ0	HAVR2_HUMAN	hepatitis A virus cellular receptor 2	286						integral to membrane				cervix(1)|large_intestine(4)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	22	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTGCTGCCTGCTGCTGACAT	0.428000													24	27					0	0	1	0	0
TLE2	7089	broad.mit.edu	37	19	3006490	3006490	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3006490G>A	ENST00000262953.6	-	15	1690	c.1428C>T	c.(1426-1428)ggC>ggT	p.G476G	TLE2_ENST00000443826.3_Silent_p.G354G|TLE2_ENST00000591529.1_Silent_p.G490G|TLE2_ENST00000455444.2_Silent_p.G354G|TLE2_ENST00000586422.1_Intron|TLE2_ENST00000447365.2_Silent_p.G143G|TLE2_ENST00000426948.2_Silent_p.G490G|TLE2_ENST00000590536.1_Silent_p.G477G	NM_003260.4	NP_003251.2	Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	476					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACAGCCCTTGCCGCCCGTGT	0.716000													4	10					0	0	1	0	0
KBTBD6	89890	broad.mit.edu	37	13	41705280	41705280	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:41705280G>A	ENST00000379485.1	-	1	1602	c.1368C>T	c.(1366-1368)tgC>tgT	p.C456C	KBTBD6_ENST00000499385.2_Silent_p.C390C	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	456							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		TAACATTGTAGCATTCCACTT	0.448000													6	54					0	0	1	0	0
FAM162A	26355	broad.mit.edu	37	3	122126189	122126189	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:122126189G>A	ENST00000477892.1	+	4	409	c.325G>A	c.(325-327)Gcc>Acc	p.A109T	FAM162A_ENST00000469967.1_Missense_Mutation_p.A109T|FAM162A_ENST00000232125.5_Missense_Mutation_p.A99T	NM_014367.3	NP_055182.3	Q96A26	F162A_HUMAN	family with sequence similarity 162, member A	109						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	6						TCTAATGATTGCCCTGACGGT	0.418000													24	18					0	0	1	0	0
MORN1	79906	broad.mit.edu	37	1	2288909	2288909	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:2288909G>A	ENST00000378531.3	-	10	1171	c.998C>T	c.(997-999)gCc>gTc	p.A333V	MORN1_ENST00000378529.3_Missense_Mutation_p.A333V|MORN1_ENST00000606372.1_5'UTR	NM_024848.1	NP_079124.1	Q5T089	MORN1_HUMAN	MORN repeat containing 1	333										breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(1)|ovary(2)	9	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		GCCATGGAGGGCACCCAAATG	0.692000													7	56					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222291329	222291329	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:222291329C>T	ENST00000281821.2	-	16	2742	c.2701G>A	c.(2701-2703)Gcc>Acc	p.A901T	EPHA4_ENST00000409938.1_Missense_Mutation_p.A901T|EPHA4_ENST00000409854.1_Missense_Mutation_p.A901T|EPHA4_ENST00000392071.4_Missense_Mutation_p.A850T	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	901						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		TCCAACAAGGCAGTGTTAGGT	0.458000													11	16					0	0	1	0	0
CAPN1	823	broad.mit.edu	37	11	64972270	64972270	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64972270C>T	ENST00000527323.1	+	10	1522	c.1282C>T	c.(1282-1284)Cgt>Tgt	p.R428C	CAPN1_ENST00000279247.6_Missense_Mutation_p.R428C|CAPN1_ENST00000524773.1_Missense_Mutation_p.R428C|CAPN1_ENST00000533820.1_Missense_Mutation_p.R428C|CAPN1_ENST00000533129.1_Missense_Mutation_p.R428C			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	428	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		GCAGAAGCACCGTCGCCGCGA	0.637000											OREG0021073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	50					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241535745	241535745	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:241535745C>T	ENST00000391984.2	+	8	1484	c.1288C>T	c.(1288-1290)Cgg>Tgg	p.R430W	CAPN10_ENST00000352879.4_Intron|CAPN10_ENST00000404753.3_Missense_Mutation_p.R430W|CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000354082.4_Intron	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	430	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		GGTAGAGAAGCGGCGGGTCAA	0.662000													15	22					0	0	1	0	0
C11orf16	56673	broad.mit.edu	37	11	8953852	8953852	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:8953852C>T	ENST00000326053.5	-	2	110	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K	C11orf16_ENST00000525780.1_Missense_Mutation_p.E2K|C11orf16_ENST00000528998.1_5'UTR	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	2										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		GTGGAGGATTCCATGGCCTTC	0.617000													5	7					0	0	1	0	0
ZNF654	55279	broad.mit.edu	37	3	88189696	88189696	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:88189696G>T	ENST00000309495.5	+	1	1443	c.1236G>T	c.(1234-1236)aaG>aaT	p.K412N	CGGBP1_ENST00000462901.1_Intron	NM_018293.2	NP_060763.2	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(1)|ovary(2)|pancreas(1)|prostate(3)	12		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TAGACCAAAAGATGCCTGACA	0.343000													18	28					2.4624e-09	2.6129e-09	1	1	0
MTHFD1L	25902	broad.mit.edu	37	6	151355736	151355736	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:151355736G>T	ENST00000367321.3	+	25	2968	c.2694_splice	c.e25+1	p.Q898_splice		NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	898	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		ACACTCAACAGGTAAAAGTTC	0.413000													13	14					7.03913e-09	7.44699e-09	1	1	0
CAD	790	broad.mit.edu	37	2	27465566	27465566	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27465566C>A	ENST00000264705.4	+	41	6463	c.6301C>A	c.(6301-6303)Ctg>Atg	p.L2101M	CAD_ENST00000403525.1_Missense_Mutation_p.L2038M	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	2101	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TCGTGTCAGCCTGCGCTACGT	0.642000													25	39					9.04412e-07	9.43082e-07	1	1	0
FBXO39	162517	broad.mit.edu	37	17	6684071	6684071	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:6684071A>G	ENST00000321535.4	+	2	1014	c.884A>G	c.(883-885)tAc>tGc	p.Y295C		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	295										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						ATCATGAAGTACGAACGCTTG	0.542000													16	22					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47231891	47231891	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47231891C>T	ENST00000391910.3	-	7	1473	c.1023G>A	c.(1021-1023)ggG>ggA	p.G341G	STRN4_ENST00000263280.6_Silent_p.G341G|STRN4_ENST00000539396.1_Silent_p.G222G|CTB-174O21.2_ENST00000600716.1_RNA			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	341						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		CATGGGGGCTCCCATCCACAG	0.632000													8	17					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94935863	94935863	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:94935863T>C	ENST00000337425.5	-	2	443	c.369A>G	c.(367-369)acA>acG	p.T123T	SERPINA9_ENST00000424550.2_Intron|SERPINA9_ENST00000298845.7_Intron|SERPINA9_ENST00000380365.3_Silent_p.T105T|SERPINA9_ENST00000448305.2_Silent_p.T25T|SERPINA9_ENST00000546329.1_Silent_p.T87T	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	105					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CAGACTCTGGTGTGTGTGTGA	0.577000													27	38					0	0	1	0	0
C11orf35	256329	broad.mit.edu	37	11	555841	555841	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:555841C>T	ENST00000329451.3	-	12	1529	c.1467G>A	c.(1465-1467)ccG>ccA	p.P489P		NM_173573.2	NP_775844.2	Q8IXW0	CK035_HUMAN	chromosome 11 open reading frame 35	489	Pro-rich.									NS(1)|breast(1)|central_nervous_system(1)|lung(4)|pancreas(1)	8		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCTCAGGGAGCGGGAAGCGGT	0.761000													5	11					0	0	1	0	0
FRMD6	122786	broad.mit.edu	37	14	52186847	52186847	+	Missense_Mutation	SNP	C	C	T	rs35856363		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:52186847C>T	ENST00000395718.2	+	11	1360	c.1075C>T	c.(1075-1077)Cgg>Tgg	p.R359W	FRMD6_ENST00000356218.4_Missense_Mutation_p.R359W|FRMD6_ENST00000553556.1_Missense_Mutation_p.R9W|FRMD6_ENST00000554167.1_Missense_Mutation_p.R290W|FRMD6_ENST00000344768.5_Missense_Mutation_p.R367W	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	367						cytoskeleton|mitochondrion|plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					AAAACGGTCGCGGGCCAGCGG	0.582000													11	14					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48699531	48699531	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48699531G>A	ENST00000544264.1	-	1	817	c.537C>T	c.(535-537)caC>caT	p.H179H	CELSR3_ENST00000164024.4_Silent_p.H179H			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	179					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGGGACCGTGGTGCCGAATCA	0.632000													32	50					0	0	1	0	0
EVI5L	115704	broad.mit.edu	37	19	7925513	7925513	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7925513C>T	ENST00000270530.4	+	13	1604	c.1408C>T	c.(1408-1410)Cgg>Tgg	p.R470W	EVI5L_ENST00000538904.2_Missense_Mutation_p.R481W	NM_145245.3	NP_660288.1	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like	470						intracellular	protein binding|Rab GTPase activator activity			breast(1)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	12						GTCGAGGCTGCGGGAGACGGA	0.662000													5	3					0	0	1	0	0
HPX	3263	broad.mit.edu	37	11	6452617	6452617	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6452617C>T	ENST00000265983.3	-	10	1313	c.1213G>A	c.(1213-1215)Gga>Aga	p.G405R		NM_000613.2	NP_000604.1	P02790	HEMO_HUMAN	hemopexin	405					cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding			endometrium(1)|large_intestine(2)|lung(11)|prostate(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		CACAAGGCTCCGTCTACCTTC	0.572000													15	25					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74593948	74593948	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74593948C>T	ENST00000361874.3	-	21	2745	c.2428G>A	c.(2428-2430)Gct>Act	p.A810T	DCTN1_ENST00000394003.3_Missense_Mutation_p.A803T|DCTN1_ENST00000407639.2_Missense_Mutation_p.A676T|DCTN1_ENST00000409567.3_Missense_Mutation_p.A790T|DCTN1_ENST00000409438.1_Missense_Mutation_p.A676T|DCTN1_ENST00000495643.1_5'UTR|DCTN1_ENST00000409240.1_Missense_Mutation_p.A773T|DCTN1_ENST00000409868.1_Missense_Mutation_p.A793T	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	810					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						ATCCCAGGAGCATCTGTCCCT	0.532000													11	62					0	0	1	0	0
CCDC51	79714	broad.mit.edu	37	3	48473935	48473935	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48473935G>A	ENST00000395694.2	-	4	1204	c.1119C>T	c.(1117-1119)gaC>gaT	p.D373D	CCDC51_ENST00000395696.1_Silent_p.D373D|CCDC51_ENST00000447018.1_Silent_p.D264D|CCDC51_ENST00000442740.1_Silent_p.D264D|CCDC51_ENST00000412398.2_Silent_p.D264D	NM_001256964.1	NP_001243893.1	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	373						integral to membrane				endometrium(4)|kidney(4)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCTGCTCCGTGTCTGACAGTG	0.557000													10	13					0	0	1	0	0
GCK	2645	broad.mit.edu	37	7	44185141	44185141	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44185141C>T	ENST00000403799.3	-	9	1677	c.1208G>A	c.(1207-1209)cGc>cAc	p.R403H	GCK_ENST00000395796.3_Missense_Mutation_p.R402H|GCK_ENST00000345378.2_Missense_Mutation_p.R404H|GCK_ENST00000437084.1_Missense_Mutation_p.R386H	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	403					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						CACAGTGATGCGCATTACGTC	0.682000													12	11					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40275408	40275408	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:40275408C>T	ENST00000302541.6	+	12	2306	c.1964C>T	c.(1963-1965)gCc>gTc	p.A655V	MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000539167.1_Missense_Mutation_p.A468V|MYRIP_ENST00000396217.3_Missense_Mutation_p.A566V|MYRIP_ENST00000425621.1_Intron|MYRIP_ENST00000444716.1_Missense_Mutation_p.A655V	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	655	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GTCATCAATGCCACAGAGGAG	0.507000													16	36					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154072581	154072581	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154072581G>A	ENST00000368559.3	-	14	1929	c.1858C>T	c.(1858-1860)Cat>Tat	p.H620Y	NUP210L_ENST00000271854.3_Missense_Mutation_p.H620Y	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	620						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			GCTGCGATATGTGTACTGGAA	0.448000													46	69					0	0	1	0	0
MIER1	57708	broad.mit.edu	37	1	67447511	67447511	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:67447511C>T	ENST00000357692.2	+	14	1428	c.1171C>T	c.(1171-1173)Cga>Tga	p.R391*	MIER1_ENST00000371018.3_Nonsense_Mutation_p.R391*|MIER1_ENST00000371014.1_Nonsense_Mutation_p.R427*|MIER1_ENST00000401041.1_Nonsense_Mutation_p.R427*|MIER1_ENST00000355977.6_Nonsense_Mutation_p.R311*|MIER1_ENST00000401042.3_Nonsense_Mutation_p.R374*|MIER1_ENST00000355356.3_Nonsense_Mutation_p.R374*|MIER1_ENST00000371016.1_Nonsense_Mutation_p.R391*	NM_001146110.1	NP_001139582.1	Q8N108	MIER1_HUMAN	mesoderm induction early response 1, transcriptional regulator	398					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(3)	15						TGCATCTAGTCGAGCACCATC	0.378000													15	21					0	0	1	0	0
DEGS2	123099	broad.mit.edu	37	14	100615732	100615732	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:100615732C>T	ENST00000305631.5	-	2	973	c.398G>A	c.(397-399)cGc>cAc	p.R133H	DEGS2_ENST00000553834.1_Intron|DEGS2_ENST00000557117.1_5'UTR	NM_206918.2	NP_996801.2	Q6QHC5	DEGS2_HUMAN	delta(4)-desaturase, sphingolipid 2	133					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity			breast(1)|lung(6)|skin(1)	8		Melanoma(154;0.212)				GCCCAGGTAGCGGTGGTGGTC	0.697000													9	7					0	0	1	0	0
TNFRSF19	55504	broad.mit.edu	37	13	24242129	24242129	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:24242129C>T	ENST00000382263.3	+	8	931	c.747C>T	c.(745-747)cgC>cgT	p.R249R	TNFRSF19_ENST00000403372.2_Silent_p.R117R|TNFRSF19_ENST00000248484.4_Silent_p.R249R|TNFRSF19_ENST00000382258.4_Silent_p.R249R	NM_001204458.1	NP_001191387.1	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily, member 19	249					apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	22		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		GGCCGGTGCGCTTGCTCCCAT	0.552000													3	6					0	0	1	0	0
HIST1H3J	8356	broad.mit.edu	37	6	27858182	27858182	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:27858182C>T	ENST00000359303.2	-	1	388	c.389G>A	c.(388-390)cGt>cAt	p.R130H		NM_003535.2	NP_003526.1	P68431	H31_HUMAN	histone cluster 1, H3j	130					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	8						GCCACGGATACGACGCGCAAG	0.502000													6	31					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33592426	33592426	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:33592426C>T	ENST00000228567.3	-	1	328	c.32G>A	c.(31-33)aGt>aAt	p.S11N	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	11						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CTGGCACAGACTGTTCACTCC	0.547000													35	70					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66259054	66259054	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66259054C>T	ENST00000532677.1	+	8	1346	c.945C>T	c.(943-945)ggC>ggT	p.G315G	DPP3_ENST00000541961.1_Silent_p.G296G|DPP3_ENST00000531863.1_Silent_p.G316G|DPP3_ENST00000453114.1_Silent_p.G296G|DPP3_ENST00000360510.2_Silent_p.G296G|DPP3_ENST00000530165.1_Silent_p.G266G	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	296					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						ACAAGAGGGGCTCCCGCTTCT	0.657000											OREG0021109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	12					0	0	1	0	0
CPXM1	56265	broad.mit.edu	37	20	2774860	2774860	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:2774860C>T	ENST00000380605.2	-	14	2245	c.2181G>A	c.(2179-2181)gaG>gaA	p.E727E		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	727					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CCCTTAGCCGCTCCAGGCGCC	0.617000													24	32					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21250654	21250654	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:21250654T>C	ENST00000417816.2	-	4	657	c.304A>G	c.(304-306)Acg>Gcg	p.T102A	NEBL_ENST00000377159.4_Missense_Mutation_p.T68A	NM_001173484.1|NM_213569.2	NP_001166955.1|NP_998734.1	O76041	NEBL_HUMAN	nebulette	765					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGAGTGTCCGTGACGATGCTG	0.448000													36	59					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56481480	56481480	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:56481480C>T	ENST00000370765.6	-	24	6892	c.6785G>A	c.(6784-6786)cGt>cAt	p.R2262H	DST_ENST00000370769.4_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000446842.2_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1604					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGGAGGAACACGAATGCCTCT	0.448000													34	48					0	0	1	0	0
TSPAN17	26262	broad.mit.edu	37	5	176083709	176083709	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176083709G>A	ENST00000298564.10	+	4	464	c.315G>A	c.(313-315)gaG>gaA	p.E105E	TSPAN17_ENST00000503045.1_Silent_p.E193E|TSPAN17_ENST00000310032.8_Silent_p.E216E|TSPAN17_ENST00000515708.1_Silent_p.E213E|TSPAN17_ENST00000508164.1_Silent_p.E213E|TSPAN17_ENST00000405525.2_Silent_p.E216E			Q96FV3	TSN17_HUMAN	tetraspanin 17	213						integral to membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|urinary_tract(1)	13	all_cancers(89;0.00141)|Renal(175;0.000269)|Lung NSC(126;0.00814)|all_lung(126;0.0133)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGAGCTGGAGCAGCAGGGCT	0.657000													13	21					0	0	1	0	0
MARCH4	57574	broad.mit.edu	37	2	217234544	217234544	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:217234544C>T	ENST00000273067.4	-	1	2206	c.440G>A	c.(439-441)cGc>cAc	p.R147H		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	147						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		CAGTGAGTAGCGATCCTCGGT	0.587000													15	22					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57325822	57325822	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:57325822G>A	ENST00000326441.9	-	10	4351	c.3988C>T	c.(3988-3990)Cca>Tca	p.P1330S	PEG3_ENST00000593695.1_Missense_Mutation_p.P1204S|PEG3_ENST00000423103.2_Missense_Mutation_p.P1330S|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.P1206S|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000593711.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1330					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCATAGAATGGTATAGCTCCT	0.423000													25	53					0	0	1	0	0
PLAU	5328	broad.mit.edu	37	10	75672731	75672731	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:75672731G>T	ENST00000446342.1	+	4	674	c.192G>T	c.(190-192)aaG>aaT	p.K64N	PLAU_ENST00000494287.1_3'UTR|PLAU_ENST00000372762.4_Missense_Mutation_p.K45N|C10orf55_ENST00000412307.2_Intron|PLAU_ENST00000372764.3_Missense_Mutation_p.K81N|C10orf55_ENST00000409178.1_Intron	NM_001145031.1	NP_001138503.1	P00749	UROK_HUMAN	plasminogen activator, urokinase	81					blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	ACCGAGGAAAGGCCAGCACTG	0.517000													20	33					4.96729e-08	5.22757e-08	1	1	0
PLAA	9373	broad.mit.edu	37	9	26907936	26907936	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:26907936A>G	ENST00000397292.3	-	13	2135	c.1718T>C	c.(1717-1719)tTg>tCg	p.L573S	PLAA_ENST00000520884.1_Missense_Mutation_p.L573S	NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	573	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		AAGAAGTATCAAGTCATCCTC	0.363000													37	40					0	0	1	0	0
OR51M1	390059	broad.mit.edu	37	11	5410880	5410880	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5410880G>A	ENST00000328611.3	+	1	274	c.252G>A	c.(250-252)ggG>ggA	p.G84G	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron	NM_001004756.2	NP_001004756.2	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M, member 1	84						integral to membrane	olfactory receptor activity			NS(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|upper_aerodigestive_tract(1)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGACCTGGGGCTGTGTGTGT	0.478000													40	41					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143094585	143094585	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:143094585G>A	ENST00000367603.2	-	5	2033	c.1291C>T	c.(1291-1293)Cgg>Tgg	p.R431W	HIVEP2_ENST00000367604.1_Missense_Mutation_p.R431W|HIVEP2_ENST00000012134.2_Missense_Mutation_p.R431W	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	431					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R431W(1)		NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GGACTAAGCCGACAGTATTTT	0.448000													22	40					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154143322	154143322	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:154143322G>A	ENST00000404039.1	+	2	662	c.75G>A	c.(73-75)ccG>ccA	p.P25P	DPP6_ENST00000332007.3_Silent_p.P27P|DPP6_ENST00000427557.1_Silent_p.P27P|DPP6_ENST00000406326.1_Silent_p.P89P|DPP6_ENST00000496611.1_3'UTR|DPP6_ENST00000377770.3_Silent_p.P89P	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	89					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GTAACCCTCCGCAGAGGAATT	0.423000													17	23					0	0	1	0	0
ADORA2A	135	broad.mit.edu	37	22	24829532	24829532	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:24829532G>A	ENST00000337539.7	+	2	619	c.160G>A	c.(160-162)Gca>Aca	p.A54T	KB-1896H10.1_ENST00000358654.2_3'UTR|ADORA2A-AS1_ENST00000326341.4_RNA|ADORA2A_ENST00000496497.1_Intron|ADORA2A-AS1_ENST00000543438.1_RNA	NM_000675.4|NM_001278497.1|NM_001278498.1|NM_001278499.1|NM_001278500.1	NP_000666.2|NP_001265426.1|NP_001265427.1|NP_001265428.1|NP_001265429.1	P29274	AA2AR_HUMAN	adenosine A2a receptor	54					apoptosis|blood coagulation|cAMP biosynthetic process|cellular defense response|inflammatory response|nerve growth factor receptor signaling pathway|phagocytosis|sensory perception	integral to plasma membrane|membrane fraction	enzyme binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|skin(1)	21	Colorectal(2;0.196)				Caffeine(DB00201)|Defibrotide(DB04932)|Pegademase bovine(DB00061)|Theophylline(DB00277)	GGCCGACATCGCAGTGGGTGT	0.617000													4	74					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133244173	133244173	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:133244173G>T	ENST00000320574.5	-	20	2278	c.2235C>A	c.(2233-2235)acC>acA	p.T745T	POLE_ENST00000535270.1_Silent_p.T718T	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	745					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GCTGGCAGATGGTGGTGAGAC	0.572000								DNA polymerases (catalytic subunits)					63	113					1.15062e-32	1.29117e-32	1	1	0
UBA1	7317	broad.mit.edu	37	X	47061766	47061766	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:47061766G>A	ENST00000335972.6	+	10	1102	c.919G>A	c.(919-921)Gtg>Atg	p.V307M	UBA1_ENST00000377351.4_Missense_Mutation_p.V307M	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	307	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GAAATCCTTGGTGGCCTCACT	0.577000													8	5					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4070021	4070021	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:4070021G>A	ENST00000274673.3	-	7	839	c.436C>T	c.(436-438)Cca>Tca	p.P146S	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	146																	AGACCTAATGGCATTGGCAGT	0.393000													27	60					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116619253	116619253	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:116619253G>A	ENST00000260210.4	-	10	1828	c.1805C>T	c.(1804-1806)gCc>gTc	p.A602V	BUD13_ENST00000375445.3_Missense_Mutation_p.A468V	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	602										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		CTTCTTGCTGGCAAGCCTGGC	0.478000													20	35					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1630763	1630763	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1630763C>T	ENST00000426508.2	-	13	1884	c.1521G>A	c.(1519-1521)tgG>tgA	p.W507*	LA16c-395F10.2_ENST00000563162.1_RNA|IFT140_ENST00000439987.2_5'UTR	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	507										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				AACTTACCTGCCAGGTTCGAA	0.438000													20	20					0	0	1	0	0
APBB3	10307	broad.mit.edu	37	5	139939991	139939991	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:139939991G>A	ENST00000358580.5	-	11	1101	c.1015C>T	c.(1015-1017)Cgc>Tgc	p.R339C	APBB3_ENST00000412920.3_Silent_p.I375I|APBB3_ENST00000511201.2_Missense_Mutation_p.R337C|APBB3_ENST00000356738.2_Silent_p.I382I|APBB3_ENST00000508496.2_Silent_p.I154I|APBB3_ENST00000357560.4_Silent_p.I377I|APBB3_ENST00000354402.5_Silent_p.I384I			O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	0	PID 2.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGGTCAGCGATGAGGCCAA	0.612000													9	13					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11304609	11304609	+	Silent	SNP	G	G	A	rs142504157		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11304609G>A	ENST00000432929.2	-	4	507	c.147C>T	c.(145-147)taC>taT	p.Y49Y	KANK2_ENST00000589359.1_Silent_p.Y49Y|KANK2_ENST00000586659.1_Silent_p.Y49Y|KANK2_ENST00000589894.1_Silent_p.Y49Y|KANK2_ENST00000355150.5_Silent_p.Y49Y	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	49										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TGTCATCCACGTACTTGAGGA	0.687000													22	26					0	0	1	0	0
OTOR	56914	broad.mit.edu	37	20	16729588	16729588	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:16729588G>A	ENST00000246081.2	+	2	236	c.192G>A	c.(190-192)caG>caA	p.Q64Q		NM_020157.2	NP_064542.1	Q9NRC9	OTOR_HUMAN	otoraplin	64	SH3.				sensory perception of sound	extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|liver(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10						AAAAAGGGCAGCAGATCTATG	0.363000													10	54					0	0	1	0	0
GOLIM4	27333	broad.mit.edu	37	3	167745559	167745559	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:167745559C>T	ENST00000470487.1	-	12	2269	c.1580G>A	c.(1579-1581)cGt>cAt	p.R527H	GOLIM4_ENST00000309027.4_Missense_Mutation_p.R499H	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	527	Glu-rich.				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TCCTTGTTCACGAGGCTCATG	0.468000													4	127					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49940296	49940296	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49940296G>A	ENST00000296474.3	-	1	774	c.747C>T	c.(745-747)taC>taT	p.Y249Y	MST1R_ENST00000344206.4_Silent_p.Y249Y|CTD-2330K9.2_ENST00000435478.1_RNA	NM_002447.2	NP_002438.2	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	249	Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		AGCTGTGCACGTATTCAATAC	0.577000													13	30					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66458794	66458794	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66458794G>A	ENST00000533211.1	-	27	5857	c.5526C>T	c.(5524-5526)caC>caT	p.H1842H	SPTBN2_ENST00000309996.2_Silent_p.H1842H|SPTBN2_ENST00000529997.1_Silent_p.H1842H			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1842					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CGTAGGCACAGTGTCGGCGCT	0.682000													29	53					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189060814	189060814	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:189060814C>A	ENST00000332517.3	+	1	242	c.102C>A	c.(100-102)agC>agA	p.S34R		NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	34					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GTGGGCACAGCTTTTGTCTGG	0.522000													76	115					1.32003e-40	1.48355e-40	1	1	0
CPA2	1358	broad.mit.edu	37	7	129919385	129919385	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:129919385G>T	ENST00000222481.4	+	9	925	c.870G>T	c.(868-870)gtG>gtT	p.V290V		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	290					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					AATCCATAGTGGACTTCATCA	0.493000													30	51					3.99451e-17	4.39387e-17	1	1	0
DNMBP	23268	broad.mit.edu	37	10	101636968	101636968	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:101636968C>T	ENST00000342239.3	-	17	4837	c.4746G>A	c.(4744-4746)gaG>gaA	p.E1582E	DNMBP_ENST00000324109.4_Silent_p.E1558E|DNMBP_ENST00000543621.1_Silent_p.E804E|DNMBP_ENST00000540316.1_Silent_p.E494E			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1558					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TCCCGTTAACCTCAGCTAACC	0.498000													41	63					0	0	1	0	0
DUSP8	1850	broad.mit.edu	37	11	1579048	1579048	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:1579048C>T	ENST00000397374.3	-	6	924	c.797G>A	c.(796-798)gGc>gAc	p.G266D	DUSP8_ENST00000528778.1_5'UTR|DUSP8_ENST00000331588.4_Missense_Mutation_p.G266D	NM_004420.2	NP_004411.2	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	266	Tyrosine-protein phosphatase.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(1)|lung(2)|prostate(1)|urinary_tract(1)	5		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		GGAGGACATGCCCATGGTCTT	0.607000													8	23					0	0	1	0	0
IRF8	3394	broad.mit.edu	37	16	85946826	85946826	+	Silent	SNP	G	G	A	rs146360039	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:85946826G>A	ENST00000268638.5	+	5	959	c.537G>A	c.(535-537)gcG>gcA	p.A179A		NM_002163.2	NP_002154.1	Q02556	IRF8_HUMAN	interferon regulatory factor 8	179					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	24		Prostate(104;0.0771)				ACTGGTGGGCGCAGCAGCCCA	0.617000													8	34					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	107157635	107157635	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:107157635G>T	ENST00000273980.4	-	15	1709	c.1262C>A	c.(1261-1263)tCt>tAt	p.S421Y	TBCK_ENST00000432496.2_Missense_Mutation_p.S421Y|TBCK_ENST00000361687.4_Missense_Mutation_p.S358Y|TBCK_ENST00000394708.2_Missense_Mutation_p.S421Y|TBCK_ENST00000394706.3_Missense_Mutation_p.S382Y			Q8TEA7	TBCK_HUMAN	TBC1 domain containing kinase	421						intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						GGCAGCTGCAGACAACTCATT	0.353000													14	30					4.3838e-07	4.58243e-07	1	1	0
CTD-2139B15.2	0	broad.mit.edu	37	5	17354235	17354235	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:17354235G>A	ENST00000511821.1	+	0	101				FTH1P10_ENST00000401830.3_RNA																							ACACTCCATCGCATTCAGCCC	0.473000													52	71					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997414	115997414	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:115997414A>G	ENST00000264363.2	-	2	1457	c.779T>C	c.(778-780)cTg>cCg	p.L260P		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	260	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATGAAGCCCCAGATCCTGAAT	0.433000													39	76					0	0	1	0	0
HS2ST1	9653	broad.mit.edu	37	1	87538637	87538637	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:87538637G>A	ENST00000370550.5	+	2	508	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	HS2ST1_ENST00000370551.4_Missense_Mutation_p.E49K|HS2ST1_ENST00000356813.4_Missense_Mutation_p.E23K|RP5-1052I5.2_ENST00000370548.2_Missense_Mutation_p.E23K	NM_012262.3	NP_036394.1	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1	49						Golgi membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)	9		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		TGCAAGACACGAAGTCCGAGA	0.413000													7	23					0	0	1	0	0
FBXO43	286151	broad.mit.edu	37	8	101154164	101154164	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:101154164C>T	ENST00000428847.2	-	2	634	c.318G>A	c.(316-318)gaG>gaA	p.E106E		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	106					meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TTTCAGGGTGCTCATAGAGTA	0.363000													18	45					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30703093	30703093	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:30703093C>T	ENST00000256246.2	-	1	3515	c.3441G>A	c.(3439-3441)caG>caA	p.Q1147Q		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1147	Ser-rich.									NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AATAAACTGACTGACTTGTAC	0.413000													22	31					0	0	1	0	0
CDAN1	146059	broad.mit.edu	37	15	43017403	43017403	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43017403A>G	ENST00000356231.3	-	27	3520	c.3497T>C	c.(3496-3498)cTg>cCg	p.L1166P		NM_138477.2	NP_612486.2	Q8IWY9	CDAN1_HUMAN	codanin 1	1166						integral to membrane	protein binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	24		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CCGTCCCATCAGACCCTTCTC	0.582000													6	18					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34067059	34067059	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:34067059C>T	ENST00000397527.1	+	18	2818	c.2098C>T	c.(2098-2100)Cgt>Tgt	p.R700C	RP3-477O4.14_ENST00000444933.1_RNA|RP3-477O4.14_ENST00000453914.1_RNA|CEP250_ENST00000342580.4_Missense_Mutation_p.R700C|RP3-477O4.14_ENST00000416260.1_RNA	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	700	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CCCTCAGTCACGTCACCAGCA	0.587000													8	17					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73729624	73729624	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73729624G>A	ENST00000200181.3	+	13	1695	c.1508G>A	c.(1507-1509)tGc>tAc	p.C503Y	ITGB4_ENST00000579662.1_Missense_Mutation_p.C503Y|ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000450894.3_Missense_Mutation_p.C503Y|ITGB4_ENST00000339591.3_Missense_Mutation_p.C503Y|ITGB4_ENST00000449880.2_Missense_Mutation_p.C503Y	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	503	Cysteine-rich tandem repeats.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			ATTCAGCCCTGCCTGCGGGAG	0.642000													9	24					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85345395	85345395	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:85345395C>T	ENST00000299927.3	+	8	3597	c.3575C>T	c.(3574-3576)gCg>gTg	p.A1192V	ZNF592_ENST00000560079.2_Missense_Mutation_p.A1192V			Q92610	ZN592_HUMAN	zinc finger protein 592	1192					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			gCGGCGGCAGCGGAGATGGCA	0.622000													8	7					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138442183	138442183	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:138442183C>T	ENST00000344876.4	-	4	3794	c.3408G>A	c.(3406-3408)taG>taA	p.*1136*	PCDH18_ENST00000412923.2_Silent_p.*1135*|PCDH18_ENST00000507846.1_Silent_p.*915*|PCDH18_ENST00000510305.1_Silent_p.*347*|PCDH18_ENST00000511115.1_Silent_p.*316*	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	0					brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					CTAAAATCTCCTAGCTCTGGC	0.423000													16	29					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903923	4903923	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:4903923G>A	ENST00000380378.1	+	1	875	c.875G>A	c.(874-876)cGc>cAc	p.R292H	MMP26_ENST00000477339.1_Intron|OR51T1_ENST00000322049.1_Missense_Mutation_p.R265H|MMP26_ENST00000380390.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTGGCACACCGCCTCTTCCAC	0.488000													25	23					0	0	1	0	0
INTS8	55656	broad.mit.edu	37	8	95839603	95839603	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:95839603G>A	ENST00000523731.1	+	3	551	c.418G>A	c.(418-420)Gcc>Acc	p.A140T	INTS8_ENST00000447247.1_Missense_Mutation_p.A140T	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	140					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					TCCGACCACTGCCATGGCTGT	0.413000													53	98					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228412316	228412316	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228412316G>A	ENST00000570156.2	+	10	3160	c.3086G>A	c.(3085-3087)tGc>tAc	p.C1029Y	OBSCN_ENST00000284548.11_Missense_Mutation_p.C937Y|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.C937Y	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1029	Ig-like 10.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCGAAAGTGTGCATGGAGGCC	0.667000													14	21					0	0	1	0	0
UAP1L1	91373	broad.mit.edu	37	9	139975224	139975224	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139975224G>A	ENST00000409858.3	+	7	1294	c.1262G>A	c.(1261-1263)cGc>cAc	p.R421H	UAP1L1_ENST00000360271.3_Missense_Mutation_p.R298H	NM_207309.2	NP_997192.2	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	421							nucleotidyltransferase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		GACAGTCCCCGCACCGCTCGC	0.677000													12	26					0	0	1	0	0
TOPBP1	11073	broad.mit.edu	37	3	133356748	133356748	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:133356748T>C	ENST00000260810.5	-	14	2623	c.2492A>G	c.(2491-2493)aAa>aGa	p.K831R		NM_007027.3	NP_008958.2	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	831					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	40						CTTGAAGAGTTTGTCCTTGGA	0.463000								Other conserved DNA damage response genes					27	45					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2408468	2408468	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2408468C>T	ENST00000332578.3	+	7	855	c.855C>T	c.(853-855)aaC>aaT	p.N285N		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	285	Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCTGTACAACGCGGACACGG	0.677000													25	42					0	0	1	0	0
CADM1	23705	broad.mit.edu	37	11	115099882	115099882	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:115099882G>A	ENST00000542447.2	-	5	800	c.672C>T	c.(670-672)caC>caT	p.H224H	CADM1_ENST00000537058.1_Silent_p.H224H|CADM1_ENST00000452722.2_Silent_p.H224H|CADM1_ENST00000537140.1_5'UTR|CADM1_ENST00000536727.1_Silent_p.H224H|CADM1_ENST00000331581.6_Silent_p.H224H	NM_001098517.1	NP_001091987.1	Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	224	Ig-like C2-type 1.				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		TGACCGCAGGGTGCTCCACCT	0.532000													25	35					0	0	1	0	0
PHKG2	5261	broad.mit.edu	37	16	30768239	30768239	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30768239C>T	ENST00000563588.1	+	10	1281	c.1042C>T	c.(1042-1044)Cac>Tac	p.H348Y	PHKG2_ENST00000424889.3_Missense_Mutation_p.H348Y|PHKG2_ENST00000328273.7_Missense_Mutation_p.H352Y	NM_000294.2	NP_000285.1	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	348	Calmodulin-binding (domain-C) (By similarity).				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)|skin(1)	2			Colorectal(24;0.198)			GTCAGTGCGGCACCTCATCGA	0.627000													34	58					0	0	1	0	0
BNIPL	149428	broad.mit.edu	37	1	151016175	151016175	+	Missense_Mutation	SNP	C	C	T	rs139447919	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151016175C>T	ENST00000295294.7	+	7	1186	c.577C>T	c.(577-579)Cgt>Tgt	p.R193C	BNIPL_ENST00000368931.3_Missense_Mutation_p.R275C	NM_001159642.1	NP_001153114.1	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein like	275	CRAL-TRIO.				apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(1)|lung(4)|skin(1)	10	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AAGCTGGATACGTCAGTGTTA	0.478000													19	31					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36770599	36770599	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:36770599G>A	ENST00000361475.2	-	7	1035	c.862C>T	c.(862-864)Ctg>Ttg	p.L288L	TGM2_ENST00000536724.1_Silent_p.L228L|TGM2_ENST00000536701.1_Silent_p.L207L	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	288					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	AGGCACCTCAGCACTGTTGGA	0.587000													10	26					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112384868	112384868	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:112384868G>A	ENST00000302475.4	-	14	2570	c.2007C>T	c.(2005-2007)tcC>tcT	p.S669S	MCC_ENST00000514701.3_5'UTR|MCC_ENST00000515367.2_Silent_p.S606S|MCC_ENST00000408903.3_Silent_p.S859S	NM_002387.2	NP_002378.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	669					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CCTCCACCTCGGACTTCAGGT	0.617000													23	31					0	0	1	0	0
HOXA3	3200	broad.mit.edu	37	7	27148262	27148262	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:27148262G>A	ENST00000396352.4	-	3	803	c.604C>T	c.(604-606)Cag>Tag	p.Q202*	HOXA3_ENST00000317201.2_Nonsense_Mutation_p.Q202*|HOXA-AS2_ENST00000518088.1_RNA	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	202					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						TCCACCAGCTGCGCGCTCGTG	0.657000													31	57					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74708915	74708915	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:74708915G>A	ENST00000308807.7	-	10	1787	c.1324C>T	c.(1324-1326)Cgg>Tgg	p.R442W	MLKL_ENST00000306247.7_Missense_Mutation_p.R234W	NM_152649.2	NP_689862.1	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like	442	Protein kinase.						ATP binding|protein binding|protein kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(6)|skin(1)|stomach(2)	19						ATGATCTCCCGCAGCTCTGAA	0.552000													12	31					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106769852	106769852	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:106769852G>A	ENST00000276185.4	+	3	133	c.133G>A	c.(133-135)Gag>Aag	p.E45K	FRMPD3-AS1_ENST00000415252.1_RNA			Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	45						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						TATGGAATGTGAGCAGCTGCC	0.527000													26	7					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52380666	52380666	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52380666G>A	ENST00000420323.2	+	11	2096	c.1835G>A	c.(1834-1836)cGc>cAc	p.R612H		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	612	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GACACACTGCGCTTCCTGGTG	0.567000													17	23					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72489064	72489064	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:72489064C>T	ENST00000373208.1	+	5	885	c.885C>T	c.(883-885)taC>taT	p.Y295Y	ADAMTS14_ENST00000373207.1_Silent_p.Y295Y	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	295	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						ATGAGATTTACCACGATGAGT	0.468000													24	50					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73569164	73569164	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73569164C>T	ENST00000392550.3	+	20	2647	c.2530C>T	c.(2530-2532)Cgg>Tgg	p.R844W	LLGL2_ENST00000167462.5_Missense_Mutation_p.R844W|LLGL2_ENST00000577200.1_Missense_Mutation_p.R844W	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	844					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding	p.R844W(2)		NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CTCAAGAGTGCGGCGGGTCAG	0.642000													5	14					0	0	1	0	0
C2orf49	79074	broad.mit.edu	37	2	105959571	105959571	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:105959571C>T	ENST00000258457.2	+	3	762	c.533C>T	c.(532-534)aCg>aTg	p.T178M	C2orf49_ENST00000437250.2_Missense_Mutation_p.T174M|C2orf49_ENST00000410049.1_Missense_Mutation_p.T136M			Q9BVC5	ASHWN_HUMAN	chromosome 2 open reading frame 49	178						tRNA-splicing ligase complex				endometrium(1)|kidney(1)|large_intestine(3)|lung(1)	6						CATGACTTAACGCATAGGAAA	0.438000													24	51					0	0	1	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100802623	100802623	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:100802623C>T	ENST00000268070.4	-	5	912	c.807G>A	c.(805-807)caG>caA	p.Q269Q		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	269	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		GGCTCTGGTGCTGAAACATAT	0.383000													34	53					0	0	1	0	0
PACS1	55690	broad.mit.edu	37	11	65978665	65978665	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65978665C>T	ENST00000320580.4	+	4	628	c.595C>T	c.(595-597)Cgt>Tgt	p.R199C		NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	199				Missing (in Ref. 2; BAC04831).	interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						AAGGAGAAAACGTTACAAGAA	0.483000													8	142					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103322655	103322655	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:103322655G>A	ENST00000424685.2	-	11	1356	c.1197C>T	c.(1195-1197)agC>agT	p.S399S	RELN_ENST00000343529.5_Silent_p.S399S|RELN_ENST00000428762.1_Silent_p.S399S			P78509	RELN_HUMAN	reelin	399					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AATTGAACTCGCTGCCTTCAT	0.448000													27	46					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52664539	52664539	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:52664539C>T	ENST00000399231.3	-	21	2842	c.2599G>A	c.(2599-2601)Gtc>Atc	p.V867I	MYO5A_ENST00000356338.6_Missense_Mutation_p.V867I|MYO5A_ENST00000358212.6_Missense_Mutation_p.V867I|MYO5A_ENST00000399233.2_Missense_Mutation_p.V867I|MYO5A_ENST00000553916.1_Missense_Mutation_p.V867I	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	867	IQ 5.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TGAATGATGACTGCTTTGTGC	0.502000													7	32					0	0	1	0	0
SCTR	6344	broad.mit.edu	37	2	120210887	120210887	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:120210887G>A	ENST00000019103.5	-	8	1094	c.827C>T	c.(826-828)gCc>gTc	p.A276V		NM_002980.2	NP_002971.2	P47872	SCTR_HUMAN	secretin receptor	276					digestion|excretion	integral to plasma membrane	secretin receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)	19					Secretin(DB00021)	AAAGTGTCTGGCAATAGCCCA	0.423000													16	33					0	0	1	0	0
SLC46A1	113235	broad.mit.edu	37	17	26731754	26731754	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26731754C>T	ENST00000440501.1	-	2	1056	c.961G>A	c.(961-963)Gcc>Acc	p.A321T	SLC46A1_ENST00000584729.1_5'UTR|SLC46A1_ENST00000321666.5_Missense_Mutation_p.A321T	NM_080669.4	NP_542400.2	Q96NT5	PCFT_HUMAN	solute carrier family 46 (folate transporter), member 1	321					cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity			lung(5)	5	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	AGCTTCAGGGCCAGCAGGCTG	0.562000													5	20					0	0	1	0	0
BRAT1	221927	broad.mit.edu	37	7	2578022	2578022	+	Missense_Mutation	SNP	G	G	A	rs140802292	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2578022G>A	ENST00000340611.4	-	14	2403	c.2147C>T	c.(2146-2148)gCg>gTg	p.A716V		NM_152743.3	NP_689956.2	Q6PJG6	BRAT1_HUMAN	BRCA1-associated ATM activator 1	716					response to ionizing radiation	nucleus	protein binding	p.A716V(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						AGACTTCTGCGCCACAGGGCG	0.627000													10	15					0	0	1	0	0
KHK	3795	broad.mit.edu	37	2	27320416	27320416	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27320416G>A	ENST00000260599.6	+	5	976	c.463G>A	c.(463-465)Gca>Aca	p.A155T	KHK_ENST00000260598.5_Missense_Mutation_p.A155T|KHK_ENST00000490823.1_3'UTR	NM_000221.2	NP_000212.1	P50053	KHK_HUMAN	ketohexokinase (fructokinase)	155					fructose catabolic process	cytosol	ATP binding|ketohexokinase activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGGATAGACGCACACAACAC	0.622000													15	16					0	0	1	0	0
RHCG	51458	broad.mit.edu	37	15	90019995	90019995	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:90019995G>A	ENST00000268122.4	-	9	1370	c.1302C>T	c.(1300-1302)gtC>gtT	p.V434V	RHCG_ENST00000544600.1_Silent_p.V434V	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	434					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					CCTCCCAGTAGACCGCATCCT	0.562000													4	32					0	0	1	0	0
PRSS21	10942	broad.mit.edu	37	16	2871093	2871093	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2871093G>A	ENST00000455114.1	+	5	788	c.682G>A	c.(682-684)Ggg>Agg	p.G228R	PRSS21_ENST00000005995.3_Missense_Mutation_p.G230R|PRSS21_ENST00000450020.3_Intron|PRSS21_ENST00000575739.1_Intron	NM_001270452.1|NM_006799.3|NM_144956.2	NP_001257381.1|NP_006790.1|NP_659205.1	Q9Y6M0	TEST_HUMAN	protease, serine, 21 (testisin)	230	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	15						TGCCCAAGGCGGGAAGGATGC	0.542000													4	174					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4824396	4824396	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:4824396G>A	ENST00000354582.6	+	49	6786	c.6436G>A	c.(6436-6438)Ggg>Agg	p.G2146R	ITPR1_ENST00000456211.2_Missense_Mutation_p.G2098R|ITPR1_ENST00000443694.2_Missense_Mutation_p.G2146R|ITPR1_ENST00000423119.2_Missense_Mutation_p.G2113R|ITPR1_ENST00000357086.4_Missense_Mutation_p.G2113R|ITPR1_ENST00000302640.8_Missense_Mutation_p.G2146R|ITPR1_ENST00000544951.1_Intron			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2161					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CAGGAACGTGGGGCACAACAT	0.542000													9	21					0	0	1	0	0
RP11-12J10.3	0	broad.mit.edu	37	10	126463302	126463302	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:126463302G>A	ENST00000494792.1	-	4	234	c.235C>T	c.(235-237)Caa>Taa	p.Q79*	METTL10_ENST00000368836.2_Missense_Mutation_p.A114V																							AAGCTGAATTGCAGAAGGAGA	0.229000													20	24					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74019736	74019736	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74019736C>A	ENST00000301607.3	-	3	452		c.e3-1		EVPL_ENST00000586740.1_Splice_Site	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin						keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						TCAGCCGGTCCTGTGGGCAGG	0.667000													5	3					0.184627	0.185007	1	1	0
CXCR2	3579	broad.mit.edu	37	2	219000152	219000152	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219000152C>A	ENST00000318507.2	+	3	1055	c.628C>A	c.(628-630)Ctg>Atg	p.L210M		NM_001557.3	NP_001548.1	P25025	CXCR2_HUMAN	chemokine (C-X-C motif) receptor 2	210					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(11)|skin(1)|stomach(1)	22						CTGGCGGATGCTGTTACGGAT	0.537000													41	44					2.77807e-22	3.09e-22	1	1	0
SPRED2	200734	broad.mit.edu	37	2	65561755	65561755	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:65561755G>A	ENST00000356388.4	-	3	546	c.357C>T	c.(355-357)atC>atT	p.I119I	SPRED2_ENST00000443619.2_Silent_p.I116I|SPRED2_ENST00000474228.1_5'UTR	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	119	WH1.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding	p.I119I(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						TAAGGTCTTCGATTGCTTTCC	0.408000													8	71					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	939316	939316	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:939316G>A	ENST00000537687.1	+	4	1944	c.1301G>A	c.(1300-1302)cGc>cAc	p.R434H	WNK1_ENST00000530271.2_Missense_Mutation_p.R434H|WNK1_ENST00000535572.1_Missense_Mutation_p.R434H|WNK1_ENST00000315939.6_Missense_Mutation_p.R434H|WNK1_ENST00000540360.1_3'UTR	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	434	Protein kinase.				intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ATCTACCGTCGCGTGACCAGT	0.448000													6	26					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143092937	143092937	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:143092937G>A	ENST00000367603.2	-	5	3681	c.2939C>T	c.(2938-2940)tCc>tTc	p.S980F	HIVEP2_ENST00000367604.1_Missense_Mutation_p.S980F|HIVEP2_ENST00000012134.2_Missense_Mutation_p.S980F	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	980	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AAAAGACATGGAGAAACTGGA	0.512000													28	53					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66460263	66460263	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:66460263C>T	ENST00000404260.3	+	29	5573	c.5265C>T	c.(5263-5265)gcC>gcT	p.A1755A	MAST4_ENST00000261569.7_Silent_p.A1558A|MAST4_ENST00000403625.2_Silent_p.A1752A|MAST4_ENST00000403666.1_Silent_p.A1563A|MAST4_ENST00000405643.1_Silent_p.A1573A			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1755						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGATGAGTGCCGTCTCTTTTG	0.622000													6	26					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33779931	33779931	+	Silent	SNP	G	G	A	rs3744902		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:33779931G>A	ENST00000261326.5	+	4	606	c.585G>A	c.(583-585)ccG>ccA	p.P195P		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	195					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	GCCAGCTGCCGCATCTCTTCT	0.557000													7	17					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	205990365	205990365	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:205990365G>T	ENST00000406610.2	+	10	1545	c.1338G>T	c.(1336-1338)caG>caT	p.Q446H	PARD3B_ENST00000349953.3_Missense_Mutation_p.Q446H|PARD3B_ENST00000462231.1_Missense_Mutation_p.Q446H|PARD3B_ENST00000358768.2_Missense_Mutation_p.Q446H|PARD3B_ENST00000351153.1_Missense_Mutation_p.Q446H	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	446	PDZ 2.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GACGAACCCAGGAAGAGCTTG	0.483000													20	34					2.27731e-05	2.3498e-05	1	1	0
VPS33B	26276	broad.mit.edu	37	15	91557641	91557641	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:91557641G>A	ENST00000333371.3	-	4	615	c.262C>T	c.(262-264)Cgc>Tgc	p.R88C	VPS33B_ENST00000535843.1_5'UTR|VPS33B_ENST00000557358.1_5'UTR|VPS33B_ENST00000535906.1_Missense_Mutation_p.R61C	NM_018668.3	NP_061138.3	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33 homolog B (yeast)	88					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|stomach(2)	16	Lung NSC(78;0.0987)|all_lung(78;0.175)					TTCTTGATGCGGGGTCTGACC	0.418000													68	115					0	0	1	0	0
CYP2U1	113612	broad.mit.edu	37	4	108866737	108866737	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:108866737A>G	ENST00000332884.6	+	2	1377	c.1102A>G	c.(1102-1104)Atg>Gtg	p.M368V	RP11-286E11.1_ENST00000513071.1_RNA|CYP2U1_ENST00000508453.1_Missense_Mutation_p.M159V	NM_183075.2	NP_898898.1	Q7Z449	CP2U1_HUMAN	cytochrome P450, family 2, subfamily U, polypeptide 1	368					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|large_intestine(2)|lung(4)|skin(2)|urinary_tract(1)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000128)		CCTGCTGTATATGTCGCTGAA	0.403000													24	105					0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77912930	77912930	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:77912930G>T	ENST00000321110.1	-	2	1283	c.988C>A	c.(988-990)Cat>Aat	p.H330N		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	330							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						CAGAGTTGATGGATGCACTGG	0.458000													11	6					1.08611e-07	1.14056e-07	1	1	0
NEO1	4756	broad.mit.edu	37	15	73585754	73585754	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:73585754C>T	ENST00000339362.5	+	27	4213	c.3766C>T	c.(3766-3768)Cat>Tat	p.H1256Y	NEO1_ENST00000261908.6_Missense_Mutation_p.H1256Y|NEO1_ENST00000560262.1_Intron|NEO1_ENST00000558964.1_Missense_Mutation_p.H1245Y			Q92859	NEO1_HUMAN	neogenin 1	1256					axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						CCATCCCATCCATTCCCTCGA	0.502000													26	99					0	0	1	0	0
PPP3CC	5533	broad.mit.edu	37	8	22355515	22355515	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22355515G>A	ENST00000240139.5	+	4	701	c.372_splice	c.e4-1	p.C125_splice	PPP3CC_ENST00000518852.1_Splice_Site_p.C125_splice|PPP3CC_ENST00000397775.3_Splice_Site_p.C125_splice|PPP3CC_ENST00000289963.8_Splice_Site_p.C125_splice	NM_005605.4	NP_005596.2	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma isozyme	125					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		GTCTTGTAGTGTGTGCTGTAT	0.323000													13	22					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127549253	127549253	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:127549253G>T	ENST00000373580.3	+	2	90		c.e2-1			NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A											endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						CCCCGCAACAGGTGTTTGGGG	0.637000													4	114					0.000602214	0.000612743	1	1	0
CMAS	55907	broad.mit.edu	37	12	22208195	22208195	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:22208195G>A	ENST00000229329.2	+	2	503	c.373G>A	c.(373-375)Gcc>Acc	p.A125T		NM_018686.4	NP_061156.1	Q8NFW8	NEUA_HUMAN	cytidine monophosphate N-acetylneuraminic acid synthetase	125					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24						CTCACTAGATGCCATCATAGA	0.318000													21	27					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16694490	16694490	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:16694490G>A	ENST00000513610.1	-	27	4244	c.3790C>T	c.(3790-3792)Cga>Tga	p.R1264*	MYO10_ENST00000427430.2_Nonsense_Mutation_p.R621*|MYO10_ENST00000505695.1_Nonsense_Mutation_p.R603*|MYO10_ENST00000274203.9_Nonsense_Mutation_p.R621*|MYO10_ENST00000515803.1_Nonsense_Mutation_p.R603*	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1264	PH 1.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						TTTGCCGTTCGCACTTCTACG	0.537000													39	69					0	0	1	0	0
GP1BA	2811	broad.mit.edu	37	17	4837102	4837102	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4837102C>T	ENST00000329125.5	+	2	1278	c.1203C>T	c.(1201-1203)acC>acT	p.T401T		NM_000173.5	NP_000164.5	E7ES66	E7ES66_HUMAN	glycoprotein Ib (platelet), alpha polypeptide	401										central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(5)|stomach(1)|urinary_tract(1)	20						ACATGACCACCCTGGAGCCCA	0.662000													14	15					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161026156	161026156	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:161026156A>G	ENST00000447678.1	-	19	2987	c.2867T>C	c.(2866-2868)gTc>gCc	p.V956A	LPA_ENST00000316300.5_Missense_Mutation_p.V956A	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3464	Kringle 9.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TCTTCCTGTGACAGTAATGAA	0.463000													13	379					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127681174	127681174	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:127681174G>A	ENST00000508053.1	-	30	4066	c.3092C>T	c.(3091-3093)gCg>gTg	p.A1031V	FBN2_ENST00000262464.4_Missense_Mutation_p.A1031V|FBN2_ENST00000508989.1_Missense_Mutation_p.A998V			P35556	FBN2_HUMAN	fibrillin 2	1031	TB 5.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCCCCAAGCCGCCCCGACAGC	0.592000													14	39					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579810	44579810	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44579810C>T	ENST00000289547.4	-	2	241	c.186G>A	c.(184-186)ccG>ccA	p.P62P	NPC1L1_ENST00000381160.3_Silent_p.P62P|NPC1L1_ENST00000423141.1_Silent_p.P62P|NPC1L1_ENST00000546276.1_Silent_p.P62P	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	62					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	TCTTGCGGGCCGGCGTGTTGG	0.592000													7	13					0	0	1	0	0
ZBED1	9189	broad.mit.edu	37	X	2407778	2407778	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:2407778G>A	ENST00000381223.4	-	2	1186	c.983C>T	c.(982-984)gCc>gTc	p.A328V	DHRSX_ENST00000334651.5_Intron|ZBED1_ENST00000381222.2_Missense_Mutation_p.A328V|ZBED1_ENST00000381218.3_Missense_Mutation_p.A328V	NM_001171135.1|NM_001171136.1|NM_004729.3	NP_001164606.1|NP_001164607.1|NP_004720.1	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	328						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	25		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CATGTACATGGCCACGGCAGA	0.627000													17	28					0	0	1	0	0
B3GALT4	8705	broad.mit.edu	37	6	33246264	33246264	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33246264C>A	ENST00000451237.1	+	1	1348	c.1068C>A	c.(1066-1068)ccC>ccA	p.P356P		NM_003782.3	NP_003773.1	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	356					protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	13						GGACTGCGCCCTTTTGCTCCT	0.612000													33	58					3.21399e-22	3.57409e-22	1	1	0
KLHL22	84861	broad.mit.edu	37	22	20800831	20800831	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:20800831G>A	ENST00000328879.4	-	6	1594	c.1438C>T	c.(1438-1440)Cct>Tct	p.P480S	KLHL22_ENST00000440659.2_Missense_Mutation_p.P337S	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	480					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CGCCGCACAGGCCCATCAGCC	0.592000													29	38					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43654236	43654236	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:43654236C>T	ENST00000360835.3	-	6	842	c.716G>A	c.(715-717)cGc>cAc	p.R239H	SCUBE1_ENST00000290460.7_Missense_Mutation_p.R239H	NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	239	EGF-like 6 (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				GATGCACGTGCGACCGTCTGA	0.647000													14	27					0	0	1	0	0
NUMA1	0	broad.mit.edu	37	11	71725527	71725527	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:71725527G>A	ENST00000393695.3	-	15	3353	c.3022C>T	c.(3022-3024)Cgg>Tgg	p.R1008W	NUMA1_ENST00000351960.6_Intron|NUMA1_ENST00000358965.6_Missense_Mutation_p.R1008W|RP11-849H4.4_ENST00000502284.1_RNA	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1008					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						TGGGTCAGCCGCGCCACCTCC	0.682000			T	RARA	APL								20	40					0	0	1	0	0
NUPL2	11097	broad.mit.edu	37	7	23235498	23235498	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:23235498C>T	ENST00000258742.5	+	4	745	c.486C>T	c.(484-486)taC>taT	p.Y162Y	NUPL2_ENST00000487595.1_3'UTR	NM_007342.2	NP_031368.1	O15504	NUPL2_HUMAN	nucleoporin like 2	162	Interaction with HIV-1 Vpr.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGCTTGAATACCATAACTTCT	0.318000													25	43					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9122871	9122871	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:9122871C>T	ENST00000382496.5	-	14	2343	c.1678G>A	c.(1678-1680)Gtg>Atg	p.V560M		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	560	TSP type-1 1.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						CAGGATCCCACGGCGCTGCCA	0.632000													4	50					0	0	1	0	0
RANBP9	10048	broad.mit.edu	37	6	13644886	13644886	+	Missense_Mutation	SNP	C	C	T	rs78716684	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:13644886C>T	ENST00000011619.3	-	6	1061	c.1003G>A	c.(1003-1005)Gtg>Atg	p.V335M	RANBP9_ENST00000539980.1_Missense_Mutation_p.V106M	NM_005493.2	NP_005484.2	Q96S59	RANB9_HUMAN	RAN binding protein 9	335					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	16	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ATATCAAACACGAAAGGATGT	0.428000													41	66					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113487330	113487330	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113487330G>A	ENST00000487903.1	+	14	1640	c.1552G>A	c.(1552-1554)Gtc>Atc	p.V518I	ATP11A_ENST00000375630.2_Missense_Mutation_p.V518I|ATP11A_ENST00000283558.8_Missense_Mutation_p.V518I|ATP11A_ENST00000375645.3_Missense_Mutation_p.V518I			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	518					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GGTCGAAGGTGTCCAGAGGTA	0.627000													36	63					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68940102	68940102	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:68940102C>T	ENST00000433211.1	-	7	1194	c.1020G>A	c.(1018-1020)caG>caA	p.Q340Q	CTNNA3_ENST00000373744.4_Silent_p.Q340Q|CTNNA3_ENST00000545309.1_Silent_p.Q340Q|CTNNA3_ENST00000494580.1_5'UTR	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	340					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						AAAGCAGATCCTGAAGAGCCT	0.502000													15	21					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27437606	27437606	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27437606C>A	ENST00000527372.1	-	18	3115	c.2935G>T	c.(2935-2937)Ggc>Tgc	p.G979C	MYO18A_ENST00000354329.4_Missense_Mutation_p.G979C|MYO18A_ENST00000533112.1_Missense_Mutation_p.G979C|MYO18A_ENST00000531253.1_Missense_Mutation_p.G979C	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	979	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GTGGCACTGCCTGCGCGGCCC	0.627000													7	9					0.00198382	0.0020125	1	1	0
SLC45A2	51151	broad.mit.edu	37	5	33951686	33951686	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:33951686T>C	ENST00000382102.3	-	5	1186	c.1129A>G	c.(1129-1131)Aac>Gac	p.N377D	SLC45A2_ENST00000296589.4_Missense_Mutation_p.N377D|SLC45A2_ENST00000342059.3_Missense_Mutation_p.N318D|SLC45A2_ENST00000345083.5_Missense_Mutation_p.N269D|SLC45A2_ENST00000509381.1_3'UTR	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	377					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						AACACGGAGTTGATGCACAAG	0.433000													40	48					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896956	175896956	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:175896956C>T	ENST00000359240.3	+	5	950	c.280C>T	c.(280-282)Cca>Tca	p.P94S	ADAM29_ENST00000404450.4_Missense_Mutation_p.P94S|ADAM29_ENST00000514159.1_Missense_Mutation_p.P94S|ADAM29_ENST00000445694.1_Missense_Mutation_p.P94S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	94					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGAGGACCAGCCATTTGTCCA	0.453000													24	30					0	0	1	0	0
DECR2	26063	broad.mit.edu	37	16	457453	457453	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:457453G>A	ENST00000219481.5	+	4	368	c.230G>A	c.(229-231)gGc>gAc	p.G77D	DECR2_ENST00000461947.1_Intron|DECR2_ENST00000397710.1_Missense_Mutation_p.G128D|DECR2_ENST00000424398.2_Missense_Mutation_p.G65D	NM_020664.3	NP_065715.1	Q9NUI1	DECR2_HUMAN	2,4-dienoyl CoA reductase 2, peroxisomal	77						peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity|binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)	9		Hepatocellular(16;0.00015)				GGGGCCACCGGCCGGCGCTGC	0.637000													13	25					0	0	1	0	0
TOX3	27324	broad.mit.edu	37	16	52484395	52484395	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:52484395C>T	ENST00000219746.9	-	4	756	c.472G>A	c.(472-474)Gtc>Atc	p.V158I	TOX3_ENST00000407228.3_Missense_Mutation_p.V153I	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	158					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						GTCATGTGGACGATGGACCGC	0.567000													12	53					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37698931	37698931	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:37698931G>A	ENST00000315215.7	+	16	2787	c.2424G>A	c.(2422-2424)acG>acA	p.T808T	GPR124_ENST00000412232.2_Silent_p.T1025T			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	1025					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TGGTGACCACGCACTTCCTGT	0.682000													4	14					0	0	1	0	0
RP9	6100	broad.mit.edu	37	7	33136124	33136124	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:33136124G>A	ENST00000297157.3	-	5	465	c.448C>T	c.(448-450)Cga>Tga	p.R150*		NM_203288.1	NP_976033.1	Q8TA86	RP9_HUMAN	retinitis pigmentosa 9 (autosomal dominant)	150	PIM1-binding (By similarity).				RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding	p.R150*(2)		large_intestine(3)|lung(3)|urinary_tract(1)	7			GBM - Glioblastoma multiforme(11;0.0403)			TTTTCATGTCGTTTATTGTCT	0.373000													27	33					0	0	1	0	0
ACLY	47	broad.mit.edu	37	17	40062868	40062868	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40062868C>T	ENST00000352035.2	-	8	909	c.779G>A	c.(778-780)aGt>aAt	p.S260N	ACLY_ENST00000537919.1_Intron|ACLY_ENST00000353196.1_Missense_Mutation_p.S260N|ACLY_ENST00000393896.2_Missense_Mutation_p.S260N|ACLY_ENST00000590151.1_Missense_Mutation_p.S260N	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	260					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				GCTTGCCCCACTTTTGGCATC	0.612000													27	36					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16255500	16255500	+	Missense_Mutation	SNP	C	C	T	rs140341054		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16255500C>T	ENST00000375759.3	+	11	2969	c.2765C>T	c.(2764-2766)aCg>aTg	p.T922M		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	922					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GTCTCTCAGACGGAGCCTGCA	0.443000													78	127					0	0	1	0	0
ZNF18	7566	broad.mit.edu	37	17	11886664	11886664	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:11886664G>A	ENST00000322748.3	-	8	1416	c.812C>T	c.(811-813)gCa>gTa	p.A271V	ZNF18_ENST00000580613.1_Missense_Mutation_p.A219V|ZNF18_ENST00000580306.1_Missense_Mutation_p.A271V|ZNF18_ENST00000454073.3_Missense_Mutation_p.A270V	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	271	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		GTATATTCCTGCCAGCTCTTC	0.433000													30	54					0	0	1	0	0
PCDHA8	0	broad.mit.edu	37	5	140222774	140222774	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140222774G>A	ENST00000531613.1	+	1	1868	c.1868G>A	c.(1867-1869)cGc>cAc	p.R623H	PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.R623H|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018911.2	NP_061734.1												p.R623H(2)		NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCCCGTTCCGCGTGGGGCTG	0.642000													38	60					0	0	1	0	0
NOL9	79707	broad.mit.edu	37	1	6589156	6589156	+	Missense_Mutation	SNP	C	C	T	rs150821604		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:6589156C>T	ENST00000377705.5	-	10	1755	c.1723G>A	c.(1723-1725)Gcc>Acc	p.A575T		NM_024654.4	NP_078930.3	Q5SY16	NOL9_HUMAN	nucleolar protein 9	575					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(2)|urinary_tract(1)	19	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCAGCTGGCGTTTACAGCA	0.507000													13	29					0	0	1	0	0
GPR26	2849	broad.mit.edu	37	10	125426420	125426420	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:125426420G>A	ENST00000284674.1	+	1	550	c.497G>A	c.(496-498)cGc>cAc	p.R166H		NM_153442.3	NP_703143.1	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	166					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	20		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				CCAGACGAGCGCCTGCGCTTC	0.682000													7	11					0	0	1	0	0
MESDC1	59274	broad.mit.edu	37	15	81295207	81295207	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:81295207G>A	ENST00000267984.2	+	1	1913	c.595G>A	c.(595-597)Gcc>Acc	p.A199T		NM_022566.2	NP_072088.1	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	199										endometrium(1)|lung(2)	3						GGACGCGTGCGCCCTGGCCAG	0.687000													6	3					0	0	1	0	0
PPP6R1	22870	broad.mit.edu	37	19	55743183	55743183	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55743183C>T	ENST00000412770.2	-	19	2859	c.2293G>A	c.(2293-2295)Gcc>Acc	p.A765T	PPP6R1_ENST00000587283.1_Missense_Mutation_p.A765T	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	765	Pro-rich.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						AGCTGCAGGGCGTCACGGGCA	0.677000													5	3					0	0	1	0	0
GDF11	0	broad.mit.edu	37	12	56143436	56143436	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56143436G>A	ENST00000257868.5	+	3	1031	c.994G>A	c.(994-996)Gca>Aca	p.A332T		NM_005811.3	NP_005802.1	O95390	GDF11_HUMAN	growth differentiation factor 11	332					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|urinary_tract(1)	12						CTGGATCATCGCACCTAAGCG	0.562000													54	81					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28714037	28714037	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:28714037G>A	ENST00000257197.3	-	13	2194	c.1933C>T	c.(1933-1935)Cct>Tct	p.P645S	DSC1_ENST00000257198.5_Missense_Mutation_p.P645S|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	645	Cadherin 5.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding	p.P645S(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ATTTGAATAGGCACAGAATAA	0.348000													37	48					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433499	55433499	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55433499C>T	ENST00000314259.3	+	1	886	c.857C>T	c.(856-858)aCa>aTa	p.T286I		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TTGATCTATACACTGAGGAAT	0.438000													21	24					0	0	1	0	0
DDX1	1653	broad.mit.edu	37	2	15747405	15747405	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:15747405G>A	ENST00000381341.2	+	14	1313	c.924G>A	c.(922-924)caG>caA	p.Q308Q	DDX1_ENST00000233084.3_Silent_p.Q308Q			Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 1	308	Helicase ATP-binding.|Necessary for interaction with RELA.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(13)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		ACATCAAGCAGTTTAAGAAAT	0.363000													30	38					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045161	87045161	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:87045161G>A	ENST00000370563.3	+	13	2289	c.2247G>A	c.(2245-2247)ttG>ttA	p.L749L	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	749						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GCCTTCCCTTGCCTGACCAAT	0.463000													30	53					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43908202	43908202	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43908202A>G	ENST00000562955.1	+	57	7893	c.7893A>G	c.(7891-7893)cgA>cgG	p.R2631R	SZT2_ENST00000372442.1_Silent_p.R1789R	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2688						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						AGAATGCACGAGCCCATCTCA	0.597000													31	42					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104089546	104089546	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104089546C>T	ENST00000388887.2	+	33	3710	c.3506C>T	c.(3505-3507)gCc>gTc	p.A1169V		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1169	FAS1 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.A1169V(1)		NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						ATTGAGGCTGCCGATGCCTAC	0.458000													19	37					0	0	1	0	0
GRHL3	57822	broad.mit.edu	37	1	24673992	24673992	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24673992G>A	ENST00000361548.4	+	14	1808	c.1578G>A	c.(1576-1578)gtG>gtA	p.V526V	GRHL3_ENST00000356046.2_Silent_p.V480V|GRHL3_ENST00000342072.4_Silent_p.V433V|GRHL3_ENST00000350501.5_Silent_p.V526V|GRHL3_ENST00000236255.4_Silent_p.V531V	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	526					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CTGAGGAGGTGTTTGACGCGC	0.582000													9	68					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150718707	150718707	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150718707T>C	ENST00000335244.4	-	5	570		c.e5-2		SLC36A2_ENST00000521967.1_Splice_Site	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2						cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACGATATGCCTAGAAGGGAGA	0.408000													29	39					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49735362	49735362	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49735362C>T	ENST00000327697.6	+	6	531	c.387C>T	c.(385-387)tgC>tgT	p.C129C	RNF123_ENST00000432042.1_5'UTR	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	129	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CTACCACATGCGTGTACAAAG	0.562000													90	147					0	0	1	0	0
PTPN18	26469	broad.mit.edu	37	2	131116855	131116855	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:131116855C>T	ENST00000175756.5	+	3	353	c.252C>T	c.(250-252)agC>agT	p.S84S	PTPN18_ENST00000347849.3_Intron|PTPN18_ENST00000420717.1_3'UTR	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	84	Tyrosine-protein phosphatase.					cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					AGGGACACAGCGACTACATTA	0.557000													22	35					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15640580	15640580	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:15640580G>A	ENST00000269703.2	+	4	482	c.283G>A	c.(283-285)Gta>Ata	p.V95I	CYP4F22_ENST00000601005.2_Missense_Mutation_p.V95I	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	95						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						CATGCACCATGTACTCTTGGT	0.547000													19	29					0	0	1	0	0
GTDC2	0	broad.mit.edu	37	3	43121705	43121705	+	Missense_Mutation	SNP	G	G	A	rs138480528	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:43121705G>A	ENST00000344697.2	-	2	1564	c.1219C>T	c.(1219-1221)Cgg>Tgg	p.R407W	GTDC2_ENST00000441964.1_Missense_Mutation_p.R407W	NM_032806.4	NP_116195.2																					TCCCAGGGCCGCTCAGGGTGT	0.612000													5	23					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107589250	107589250	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:107589250G>A	ENST00000374736.3	-	16	2710	c.2316C>T	c.(2314-2316)ggC>ggT	p.G772G	ABCA1_ENST00000494467.1_5'UTR	NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	772					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGAGTGTGAAGCCCACGTAGT	0.537000													6	14					0	0	1	0	0
UHMK1	127933	broad.mit.edu	37	1	162469789	162469789	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:162469789C>T	ENST00000489294.1	+	2	471	c.313C>T	c.(313-315)Cca>Tca	p.P105S	UHMK1_ENST00000282169.8_3'UTR|UHMK1_ENST00000545294.1_Missense_Mutation_p.P31S|UHMK1_ENST00000538489.1_Missense_Mutation_p.P105S	NM_175866.4	NP_787062.1	Q8TAS1	UHMK1_HUMAN	U2AF homology motif (UHM) kinase 1	105	Protein kinase.				cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding			endometrium(1)|large_intestine(2)|lung(6)|prostate(2)	11	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TCCAAATGTGCCATCACGCTG	0.383000													24	82					0	0	1	0	0
PXK	54899	broad.mit.edu	37	3	58351637	58351637	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58351637G>A	ENST00000356151.2	+	2	248	c.139G>A	c.(139-141)Gaa>Aaa	p.E47K	PXK_ENST00000463280.1_Intron|PXK_ENST00000536660.1_Intron|PXK_ENST00000302779.5_Intron|PXK_ENST00000383715.4_Intron|PXK_ENST00000484288.1_Missense_Mutation_p.E47K|PXK_ENST00000479241.1_Intron|PXK_ENST00000383716.3_Intron	NM_017771.3	NP_060241.2	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	47	PX.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		AATTTCTGTGGAAAACAGCTG	0.353000													18	27					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11259693	11259693	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11259693T>G	ENST00000361445.4	-	27	4088	c.4012A>C	c.(4012-4014)Atc>Ctc	p.I1338L		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1338					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						ATGCTTCTGATGAGCTCATCC	0.483000													29	30					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80895147	80895147	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80895147C>T	ENST00000355528.4	+	35	3322	c.3191_splice	c.e35-1	p.D1064_splice	TBCD_ENST00000539345.2_Splice_Site_p.D1064_splice	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	1064					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			GTTCTTCCAGCCACCCCTTTG	0.478000													13	23					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62385158	62385158	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:62385158C>T	ENST00000383710.4	-	30	4334	c.3985G>A	c.(3985-3987)Gca>Aca	p.A1329T	CADPS_ENST00000283269.9_Missense_Mutation_p.A1290T|CADPS_ENST00000357948.3_Missense_Mutation_p.A1250T	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1329	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CTCACTGATGCTGTGGCTTCC	0.517000													27	66					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119052898	119052898	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:119052898C>T	ENST00000409109.1	+	9	3037	c.2450C>T	c.(2449-2451)aCg>aTg	p.T817M	NLRX1_ENST00000525863.1_Missense_Mutation_p.T817M|NLRX1_ENST00000469103.2_3'UTR|NLRX1_ENST00000409991.1_Missense_Mutation_p.T817M|NLRX1_ENST00000409265.4_Missense_Mutation_p.T817M|NLRX1_ENST00000292199.2_Missense_Mutation_p.T817M			Q86UT6	NLRX1_HUMAN	NLR family member X1	817	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CTGCTGCACACGGGCCTTGGG	0.647000													29	39					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90422347	90422347	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:90422347C>T	ENST00000369393.3	-	48	7492	c.7377G>A	c.(7375-7377)caG>caA	p.Q2459Q	MDN1_ENST00000428876.1_Silent_p.Q2459Q			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	2459					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ATACTAAGATCTGTCCATCTC	0.483000													33	52					0	0	1	0	0
ETV1	2115	broad.mit.edu	37	7	13949324	13949324	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:13949324G>T	ENST00000343495.5	-	10	1557	c.817_splice	c.e10-1	p.G273_splice	ETV1_ENST00000405358.4_Splice_Site_p.G305_splice|ETV1_ENST00000242066.5_Splice_Site_p.G273_splice|ETV1_ENST00000405192.2_Splice_Site_p.G268_splice|ETV1_ENST00000399357.3_Splice_Site_p.G188_splice|ETV1_ENST00000403685.1_Splice_Site_p.G273_splice|ETV1_ENST00000420159.2_Splice_Site_p.G233_splice|ETV1_ENST00000405218.2_Splice_Site_p.G291_splice|ETV1_ENST00000403527.1_Splice_Site_p.G251_splice|ETV1_ENST00000430479.1_Splice_Site_p.G291_splice			P50549	ETV1_HUMAN	ets variant 1	291				Missing (in Ref. 5; AAC62435).	transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						CAAACATACAGCCTGTGGATG	0.343000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								12	42					6.40141e-05	6.5734e-05	1	1	0
RASAL2	9462	broad.mit.edu	37	1	178420766	178420766	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:178420766G>A	ENST00000448150.3	+	10	2452	c.1634G>A	c.(1633-1635)tGt>tAt	p.C545Y	RASAL2_ENST00000367649.3_Missense_Mutation_p.C563Y|RASAL2_ENST00000462775.1_Missense_Mutation_p.C415Y	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	415					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						CCCAGCAAATGTTCATCTAGT	0.408000													54	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179598396	179598396	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179598396G>A	ENST00000589042.1	-	53	15944	c.15720C>T	c.(15718-15720)tgC>tgT	p.C5240C	TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.C4923C|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Silent_p.C3996C|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4923	Ig-like 33.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCAGCCAGGCACGTGTATT	0.368000													30	35					0	0	1	0	0
PGM5	5239	broad.mit.edu	37	9	71144510	71144510	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:71144510G>A	ENST00000396396.1	+	11	1871	c.1642G>A	c.(1642-1644)Gca>Aca	p.A548T		NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	548					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						CATAGCCATCGCACTGAAAAT	0.483000													13	21					0	0	1	0	0
SLC18A1	6570	broad.mit.edu	37	8	20036993	20036993	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:20036993G>A	ENST00000440926.1	-	4	597	c.127C>T	c.(127-129)Cca>Tca	p.P43S	SLC18A1_ENST00000519026.1_Missense_Mutation_p.P43S|SLC18A1_ENST00000437980.1_Missense_Mutation_p.P43S|SLC18A1_ENST00000381608.4_Missense_Mutation_p.P43S|SLC18A1_ENST00000276373.5_Missense_Mutation_p.P43S|SLC18A1_ENST00000265808.7_Missense_Mutation_p.P43S	NM_001135691.2	NP_001129163.1	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 1	43					neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29				Colorectal(74;0.0747)		GGCACAATTGGCACTGAAAGT	0.507000													19	26					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28601284	28601284	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:28601284C>T	ENST00000380982.4	-	17	2229	c.2148G>A	c.(2146-2148)gaG>gaA	p.E716E	FLT3_ENST00000241453.7_Silent_p.E716E|FLT3_ENST00000537084.1_Silent_p.E716E			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	716	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CCTTGAAAATCTCTGTCCAAG	0.363000			"""Mis, O"""		"""AML, ALL"""								52	57					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107423293	107423293	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:107423293G>A	ENST00000340010.5	-	11	1444	c.1260C>T	c.(1258-1260)atC>atT	p.I420I	SLC26A3_ENST00000422236.2_Silent_p.I385I	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	420					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						CAATCAGCACGATGATGGCAC	0.418000													12	24					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101731785	101731785	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:101731785C>T	ENST00000342239.3	-	2	188	c.97G>A	c.(97-99)Gca>Aca	p.A33T	DNMBP_ENST00000324109.4_Missense_Mutation_p.A33T			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	33	SH3 1.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TCCACCACTGCCAGCACCTCA	0.463000													71	119					0	0	1	0	0
FZD9	8326	broad.mit.edu	37	7	72849210	72849210	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:72849210C>T	ENST00000344575.3	+	1	1102	c.873C>T	c.(871-873)agC>agT	p.S291S		NM_003508.2	NP_003499.1	O00144	FZD9_HUMAN	frizzled family receptor 9	291					B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	14		Lung NSC(55;0.0659)|all_lung(88;0.152)				GAGCGCAGAGCGTGGCCTGTG	0.637000													22	56					0	0	1	0	0
TREML3P	0	broad.mit.edu	37	6	41185472	41185472	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:41185472C>T	ENST00000564680.1	-	0	213																											CAGTAGGATCCCGAGTCCTCC	0.463000													4	4					0	0	1	0	0
PAOX	196743	broad.mit.edu	37	10	135204901	135204901	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:135204901C>T	ENST00000278060.5	+	7	1561	c.1478C>T	c.(1477-1479)gCc>gTc	p.A493V	RP11-108K14.8_ENST00000468317.2_Silent_p.G32G|PAOX_ENST00000357296.3_Silent_p.G440G|PAOX_ENST00000480071.2_3'UTR|PAOX_ENST00000368539.4_3'UTR|PAOX_ENST00000368535.2_3'UTR	NM_152911.2	NP_690875.1	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino)	631					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|urinary_tract(2)	23		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		TGGAGGGAGGCCGACCGCCTC	0.662000													19	46					0	0	1	0	0
NKPD1	284353	broad.mit.edu	37	19	45656163	45656163	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45656163G>A	ENST00000317951.4	-	4	1531	c.1532C>T	c.(1531-1533)aCg>aTg	p.T511M	NKPD1_ENST00000429338.1_Missense_Mutation_p.T289M|NKPD1_ENST00000438936.2_Missense_Mutation_p.T289M|NKPD1_ENST00000589776.1_Missense_Mutation_p.T289M	NM_198478.3	NP_940880.3			NTPase, KAP family P-loop domain containing 1											endometrium(1)|lung(4)|prostate(2)|urinary_tract(1)	8		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		GTTATCGGCCGTGCCCTTCAT	0.637000													4	3					0	0	1	0	0
FAM120B	84498	broad.mit.edu	37	6	170626692	170626692	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:170626692C>T	ENST00000476287.1	+	2	322	c.214C>T	c.(214-216)Cga>Tga	p.R72*	FAM120B_ENST00000537664.1_Nonsense_Mutation_p.R95*|FAM120B_ENST00000540480.1_Nonsense_Mutation_p.R84*|FAM120B_ENST00000252510.9_Intron	NM_032448.1	NP_115824.1	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	72					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.R72*(1)		endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(2)	44		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		TTCTGCTTTGCGAGATTTTGT	0.443000													26	39					0	0	1	0	0
PRKCE	5581	broad.mit.edu	37	2	46237637	46237637	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:46237637A>G	ENST00000306156.3	+	10	1745	c.1418A>G	c.(1417-1419)tAc>tGc	p.Y473C	PRKCE_ENST00000394874.1_Missense_Mutation_p.Y196C	NM_005400.2	NP_005391.1	Q02156	KPCE_HUMAN	protein kinase C, epsilon	473	Protein kinase.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity		MBOAT2/PRKCE(2)	breast(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(13)|ovary(3)|upper_aerodigestive_tract(2)	34		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			ACCCAACTCTACTGCTGCTTC	0.478000													23	21					0	0	1	0	0
XAB2	56949	broad.mit.edu	37	19	7687308	7687308	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7687308C>T	ENST00000358368.4	-	12	1563	c.1526G>A	c.(1525-1527)cGc>cAc	p.R509H	XAB2_ENST00000534844.1_Missense_Mutation_p.R506H	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	509					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						GTCCAGGATGCGGTCGTACAC	0.617000								Direct reversal of damage;Nucleotide excision repair (NER)					48	72					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5988467	5988467	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:5988467A>G	ENST00000399933.3	-	2	671	c.672T>C	c.(670-672)tgT>tgC	p.C224C	KIAA2026_ENST00000381461.2_Silent_p.C224C	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	224										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTGTTGAGGTACATGCAGTTC	0.433000													6	58					0	0	1	0	0
TPD52L3	89882	broad.mit.edu	37	9	6328941	6328941	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:6328941G>A	ENST00000344545.5	+	1	593	c.346G>A	c.(346-348)Gcc>Acc	p.A116T	TPD52L3_ENST00000381428.1_Missense_Mutation_p.A116T|TPD52L3_ENST00000314556.3_Missense_Mutation_p.A116T	NM_033516.5	NP_277051.3	Q96J77	TPD55_HUMAN	tumor protein D52-like 3	116							protein binding			large_intestine(1)|lung(9)|skin(1)	11		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		GAAGAAGTCGGCCACATTCAG	0.517000													22	40					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79581055	79581055	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:79581055C>T	ENST00000372391.2	-	15	3192	c.3187G>A	c.(3187-3189)Gca>Aca	p.A1063T	DLG5_ENST00000459739.1_5'UTR|DLG5_ENST00000372388.2_Intron	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1063	Pro-rich.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GGGGGTGATGCGTGCATGGGC	0.647000													10	16					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101203801	101203801	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:101203801T>C	ENST00000294728.2	+	9	2283	c.2182T>C	c.(2182-2184)Tca>Cca	p.S728P	VCAM1_ENST00000347652.2_Missense_Mutation_p.S636P|VCAM1_ENST00000370115.1_Missense_Mutation_p.S529P|VCAM1_ENST00000370119.4_Missense_Mutation_p.S666P	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	728					heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CATGAAGGGGTCATATAGTCT	0.378000													29	45					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10916630	10916630	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10916630C>T	ENST00000314646.5	+	13	1696	c.1532C>T	c.(1531-1533)gCc>gTc	p.A511V	DNM2_ENST00000359692.6_Missense_Mutation_p.A511V|DNM2_ENST00000355667.6_Missense_Mutation_p.A511V|DNM2_ENST00000585892.1_Missense_Mutation_p.A511V|DNM2_ENST00000408974.4_Missense_Mutation_p.A511V|DNM2_ENST00000389253.4_Missense_Mutation_p.A511V			P50570	DYN2_HUMAN	dynamin 2	511					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			AAGAAGAGAGCCATCCCCAAT	0.607000			"""F, N, Splice, Mis, O"""		ETP ALL								13	15					0	0	1	0	0
PCDHGB7	0	broad.mit.edu	37	5	140799298	140799298	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140799298C>T	ENST00000398594.2	+	1	1872	c.1872C>T	c.(1870-1872)ggC>ggT	p.G624G	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGAACAGGCGAGGTGCGCA	0.657000													4	72					0	0	1	0	0
COMMD7	149951	broad.mit.edu	37	20	31294522	31294522	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31294522C>T	ENST00000446419.1	-	4	895	c.279G>A	c.(277-279)gcG>gcA	p.A93A	COMMD7_ENST00000278980.6_Silent_p.A94A	NM_001099339.1	NP_001092809.1	Q86VX2	COMD7_HUMAN	COMM domain containing 7	94					negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|tumor necrosis factor-mediated signaling pathway		NF-kappaB binding	p.A94A(1)		breast(1)|endometrium(1)|lung(3)	5						TTATGAAATCCGCCTGGACCT	0.473000													18	31					0	0	1	0	0
ZNF655	79027	broad.mit.edu	37	7	99170592	99170592	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99170592C>A	ENST00000424881.1	+	4	1186	c.966C>A	c.(964-966)agC>agA	p.S322R	ZNF655_ENST00000394163.2_Missense_Mutation_p.S287R|ZNF655_ENST00000425063.1_3'UTR|ZNF655_ENST00000493277.1_Missense_Mutation_p.S322R|ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000252713.4_Missense_Mutation_p.S287R	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	287					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GTAGTCCAAGCTCAGGCATAA	0.388000													24	41					4.47668e-21	4.96907e-21	1	1	0
NPC1	4864	broad.mit.edu	37	18	21124372	21124372	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:21124372A>G	ENST00000269228.5	-	13	2620	c.2066T>C	c.(2065-2067)gTc>gCc	p.V689A	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Missense_Mutation_p.V371A	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	689	SSD.				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GAACGGGATGACTTCAATCAC	0.532000													11	14					0	0	1	0	0
ACTR6	64431	broad.mit.edu	37	12	100613796	100613796	+	Silent	SNP	G	G	A	rs140292829		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:100613796G>A	ENST00000188312.2	+	10	1698	c.933G>A	c.(931-933)ccG>ccA	p.P311P	ACTR6_ENST00000546902.1_Silent_p.P229P|ACTR6_ENST00000551617.1_Intron|ACTR6_ENST00000552376.1_Intron	NM_022496.4	NP_071941.1	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog (yeast)	311						cytoplasm|cytoskeleton				autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	14						AAATGCAGCCGCATTTTTTTA	0.373000													6	46					0	0	1	0	0
CNOT6L	246175	broad.mit.edu	37	4	78647372	78647372	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:78647372G>A	ENST00000504123.1	-	11	1534	c.1404C>T	c.(1402-1404)agC>agT	p.S468S	CNOT6L_ENST00000264903.4_Silent_p.S468S			Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	468					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	9						TTTCATAGGCGCTCTTAAGTT	0.408000													22	118					0	0	1	0	0
DDIT4	54541	broad.mit.edu	37	10	74034170	74034170	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:74034170C>T	ENST00000307365.3	+	2	397	c.196C>T	c.(196-198)Ccg>Tcg	p.P66S		NM_019058.2	NP_061931.1	Q9NX09	DDIT4_HUMAN	DNA-damage-inducible transcript 4	66					apoptosis					cervix(1)|endometrium(2)|lung(5)|pancreas(1)|prostate(2)|urinary_tract(1)	12						TGGCTTCGGGCCGGAGGAAGG	0.711000													7	12					0	0	1	0	0
FADS2	9415	broad.mit.edu	37	11	61583828	61583828	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61583828C>A	ENST00000257261.6	+	1	101	c.71C>A	c.(70-72)aCt>aAt	p.T24N	FADS1_ENST00000350997.7_Intron|FADS1_ENST00000541683.1_Intron|FADS2_ENST00000574708.1_Intron			O95864	FADS2_HUMAN	fatty acid desaturase 2	0	Cytochrome b5 heme-binding.				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			breast(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20					Alpha-Linolenic Acid(DB00132)	ACTCCCCAGACTCCACTTCTC	0.622000													12	19					9.05144e-12	9.75833e-12	1	1	0
SOS1	6654	broad.mit.edu	37	2	39250215	39250215	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:39250215G>A	ENST00000426016.1	-	11	1440	c.1354C>T	c.(1354-1356)Cgt>Tgt	p.R452C	SOS1_ENST00000395038.2_Missense_Mutation_p.R452C|SOS1_ENST00000472480.1_5'UTR|SOS1_ENST00000402219.2_Missense_Mutation_p.R452C			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	452	PH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				GCTCCTACACGTGTAAGAGTT	0.388000									Noonan syndrome				37	47					0	0	1	0	0
CYS1	192668	broad.mit.edu	37	2	10199026	10199026	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:10199026G>A	ENST00000381813.4	-	3	618	c.431C>T	c.(430-432)tCg>tTg	p.S144L	CYS1_ENST00000477304.1_5'UTR	NM_001037160.2	NP_001032237.1	Q717R9	CYS1_HUMAN	cystin 1	144						cilium axoneme				large_intestine(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.166)|OV - Ovarian serous cystadenocarcinoma(76;0.227)		CCCCTCTTCCGAGTGGTCGTA	0.672000													7	7					0	0	1	0	0
TDRKH	11022	broad.mit.edu	37	1	151752566	151752566	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151752566G>A	ENST00000368822.1	-	4	915	c.282C>T	c.(280-282)ggC>ggT	p.G94G	TDRKH_ENST00000368827.6_Silent_p.G94G|TDRKH_ENST00000458431.2_Silent_p.G94G|TDRKH_ENST00000368823.1_Silent_p.G90G|TDRKH_ENST00000484421.1_5'UTR|TDRKH_ENST00000440583.2_5'UTR|TDRKH_ENST00000368825.3_Silent_p.G94G|TDRKH_ENST00000368824.3_Silent_p.G94G			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	94	KH 1.						RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTCGCTCATCGCCTACATCCT	0.502000													24	59					0	0	1	0	0
THRA	7067	broad.mit.edu	37	17	38241019	38241019	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38241019G>A	ENST00000450525.2	+	6	1018	c.527G>A	c.(526-528)cGc>cAc	p.R176H	THRA_ENST00000584985.1_Missense_Mutation_p.R176H|THRA_ENST00000546243.1_Missense_Mutation_p.R176H|THRA_ENST00000394121.4_Missense_Mutation_p.R176H|THRA_ENST00000264637.4_Missense_Mutation_p.R176H	NM_199334.3	NP_955366.1	P10827	THA_HUMAN	thyroid hormone receptor, alpha	176					negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)	11	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	GAGGCCCATCGCAGCACCAAT	0.602000													19	41					0	0	1	0	0
PILRA	29992	broad.mit.edu	37	7	99971947	99971947	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99971947G>A	ENST00000198536.2	+	2	557	c.345G>A	c.(343-345)ctG>ctA	p.L115L	PILRA_ENST00000394000.2_Silent_p.L115L|PILRA_ENST00000453419.1_Silent_p.L115L|PILRA_ENST00000474013.1_3'UTR|PILRA_ENST00000350573.2_Silent_p.L115L	NM_013439.2	NP_038467.2	Q9UKJ1	PILRA_HUMAN	paired immunoglobin-like type 2 receptor alpha	115	Ig-like V-type.				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity	p.L115L(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	15	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCTCCAACCTGCAGAAGCAGG	0.557000													53	58					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95132766	95132766	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:95132766G>A	ENST00000371501.4	-	24	2500	c.2378C>T	c.(2377-2379)gCa>gTa	p.A793V	MYOF_ENST00000358334.5_Missense_Mutation_p.A780V|MYOF_ENST00000359263.4_Missense_Mutation_p.A793V|MYOF_ENST00000371502.4_Missense_Mutation_p.A793V			Q9NZM1	MYOF_HUMAN	myoferlin	793					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GACCTGATGTGCGGGAATTCG	0.483000													40	52					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7334785	7334785	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7334785G>A	ENST00000318881.6	+	3	894	c.657G>A	c.(655-657)aaG>aaA	p.K219K	SYT9_ENST00000396716.2_Silent_p.K187K	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	219						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GTAACAGCAAGGCTTGTGGGA	0.398000													33	55					0	0	1	0	0
TSSK6	83983	broad.mit.edu	37	19	19625628	19625628	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19625628G>A	ENST00000360913.3	-	1	1210	c.609C>T	c.(607-609)taC>taT	p.Y203Y	TSSK6_ENST00000585580.3_Silent_p.Y203Y			Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6	203	Protein kinase.				multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	16						TGACCATGACGTAGAGCACGA	0.662000													22	24					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71394314	71394314	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:71394314G>A	ENST00000392650.3	-	24	3214	c.3214C>T	c.(3214-3216)Cgc>Tgc	p.R1072C	SDK2_ENST00000388726.3_Missense_Mutation_p.R1072C	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1072	Fibronectin type-III 5.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						TTCACCTGGCGCATGCGGAAG	0.622000													8	22					0	0	1	0	0
SMC6	79677	broad.mit.edu	37	2	17902486	17902486	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:17902486G>A	ENST00000448223.2	-	10	1038	c.769C>T	c.(769-771)Cgt>Tgt	p.R257C	SMC6_ENST00000351948.4_Missense_Mutation_p.R257C|SMC6_ENST00000381272.4_Missense_Mutation_p.R283C|SMC6_ENST00000402989.1_Missense_Mutation_p.R257C	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	257					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTTTGAAAACGTTCCTCTTTC	0.333000													11	63					0	0	1	0	0
EMC1	23065	broad.mit.edu	37	1	19568918	19568918	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:19568918C>T	ENST00000477853.1	-	5	472	c.430G>A	c.(430-432)Gca>Aca	p.A144T	EMC1_ENST00000375199.3_Missense_Mutation_p.A144T|EMC1_ENST00000375208.3_Missense_Mutation_p.A122T	NM_001271428.1|NM_015047.1	NP_001258357.1|NP_055862.1			ER membrane protein complex subunit 1																		TTCAGGACTGCGATGTACCTT	0.562000													4	48					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103191670	103191670	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:103191670G>A	ENST00000424685.2	-	41	6305	c.6146C>T	c.(6145-6147)gCg>gTg	p.A2049V	RELN_ENST00000343529.5_Missense_Mutation_p.A2049V|RELN_ENST00000428762.1_Missense_Mutation_p.A2049V			P78509	RELN_HUMAN	reelin	2049					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.A2049V(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GTGCCAGGTCGCCCCGAAGTC	0.547000													9	15					0	0	1	0	0
SLC51A	200931	broad.mit.edu	37	3	195955719	195955719	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195955719C>T	ENST00000296327.5	+	6	770	c.561C>T	c.(559-561)taC>taT	p.Y187Y		NM_152672.5	NP_689885.4			solute carrier family 51, alpha subunit																		CTTTCCAATACGCCTTCTTGA	0.582000													4	111					0	0	1	0	0
KLHL10	317719	broad.mit.edu	37	17	40001400	40001400	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40001400C>T	ENST00000293303.4	+	3	860	c.707C>T	c.(706-708)gCt>gTt	p.A236V		NM_152467.3	NP_689680.2	Q6JEL2	KLH10_HUMAN	kelch-like family member 10	236						cytoplasm				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26		Breast(137;0.000162)				CTAATGCATGCTGAGTACTTC	0.443000													17	21					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79461527	79461527	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:79461527C>T	ENST00000376718.3	-	4	535	c.412G>A	c.(412-414)Gtt>Att	p.V138I	PRUNE2_ENST00000376713.3_Missense_Mutation_p.V138I|PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	138					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CGGAACTCAACGTTGGCATCG	0.488000													20	25					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32221864	32221864	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32221864T>C	ENST00000373658.3	-	4	915	c.574A>G	c.(574-576)Aac>Gac	p.N192D	BAI2_ENST00000398538.1_Missense_Mutation_p.N180D|BAI2_ENST00000527361.1_Missense_Mutation_p.N192D|BAI2_ENST00000373655.2_Missense_Mutation_p.N192D|BAI2_ENST00000398542.1_Missense_Mutation_p.N180D|BAI2_ENST00000398556.3_Missense_Mutation_p.N195D|BAI2_ENST00000398547.1_Missense_Mutation_p.N180D|BAI2_ENST00000257070.4_Missense_Mutation_p.N192D	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	192	Poly-Asn.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TGGCTAGAGTTGTTGTTGTTG	0.662000													17	33					0	0	1	0	0
C16orf72	29035	broad.mit.edu	37	16	9210616	9210616	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:9210616G>A	ENST00000327827.7	+	4	1072	c.675G>A	c.(673-675)agG>agA	p.R225R		NM_014117.2	NP_054836.2	Q14CZ0	CP072_HUMAN	chromosome 16 open reading frame 72	225										endometrium(4)|large_intestine(2)|lung(2)	8						CTAGTCGAAGGAGAAATGGAC	0.473000													35	61					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51372228	51372228	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:51372228G>A	ENST00000216392.7	-	20	2758	c.2426C>T	c.(2425-2427)tCg>tTg	p.S809L	PYGL_ENST00000544180.2_Missense_Mutation_p.S775L|PYGL_ENST00000532462.1_Intron	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	809					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	GAATTTCCCCGAGGCAGCTAT	0.423000													51	80					0	0	1	0	0
SCAP	22937	broad.mit.edu	37	3	47455371	47455371	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47455371C>T	ENST00000265565.5	-	23	4225	c.3813G>A	c.(3811-3813)gtG>gtA	p.V1271V	SCAP_ENST00000441517.2_Silent_p.V1015V|SCAP_ENST00000545718.1_Silent_p.V878V	NM_012235.2	NP_036367.2	Q12770	SCAP_HUMAN	SREBF chaperone	1271	Interaction with SREBF2 (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GCACAGAGGGCACATACACCA	0.627000													54	82					0	0	1	0	0
WIPF3	644150	broad.mit.edu	37	7	29927787	29927787	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:29927787G>A	ENST00000409290.1	+	5	1203	c.1203G>A	c.(1201-1203)acG>acA	p.T401T	WIPF3_ENST00000409123.1_Silent_p.T401T|WIPF3_ENST00000242140.5_Silent_p.T401T	NM_001080529.2	NP_001073998.2	B8ZZV2	B8ZZV2_HUMAN	WAS/WASL interacting protein family, member 3	401										breast(2)|large_intestine(3)|lung(6)|ovary(1)	12						GGACCCCGACGCAGCAGCCTG	0.587000													6	1					0	0	1	0	0
CLPTM1	1209	broad.mit.edu	37	19	45490618	45490618	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45490618G>A	ENST00000541297.2	+	8	1398	c.933G>A	c.(931-933)tcG>tcA	p.S311S	CLPTM1_ENST00000546079.1_Silent_p.S223S|CLPTM1_ENST00000589158.1_3'UTR|CLPTM1_ENST00000337392.5_Silent_p.S325S			O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane protein 1	325					cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GCACCAAGTCGCCCTGGAACT	0.642000													24	17					0	0	1	0	0
SIX2	10736	broad.mit.edu	37	2	45235795	45235795	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:45235795C>T	ENST00000303077.6	-	1	774	c.455G>A	c.(454-456)cGc>cAc	p.R152H		NM_016932.4	NP_058628.3	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	152						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(6)|large_intestine(3)|lung(8)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	22		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				ACGCTTCTCGCGGGGTGAAGG	0.667000													12	52					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	183056679	183056679	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:183056679A>G	ENST00000328913.3	-	5	692	c.395T>C	c.(394-396)aTa>aCa	p.I132T	MCF2L2_ENST00000447025.2_Missense_Mutation_p.I132T|MCF2L2_ENST00000473233.1_Missense_Mutation_p.I132T|MCF2L2_ENST00000414362.2_Missense_Mutation_p.I132T	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	132	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			AAGGATGAATATGAGCTGTAA	0.423000													16	20					0	0	1	0	0
MIR7-2	0	broad.mit.edu	37	15	89155150	89155150	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:89155150G>A	ENST00000384970.1	+	0	95					NR_029606.1|NR_039867.1																						TCTACCTAATGGTGCCAGCCA	0.502000													7	14					0	0	1	0	0
ZNF106	64397	broad.mit.edu	37	15	42740533	42740533	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42740533G>A	ENST00000263805.4	-	3	3129	c.2803C>T	c.(2803-2805)Cga>Tga	p.R935*	ZNF106_ENST00000565611.1_Nonsense_Mutation_p.R120*|ZNF106_ENST00000565380.1_Nonsense_Mutation_p.R163*	NM_022473.1	NP_071918.1			zinc finger protein 106																		GCACTATGTCGCCTTTGGGTA	0.478000													73	82					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124906083	124906083	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:124906083G>A	ENST00000423114.2	-	4	474	c.475C>T	c.(475-477)Cag>Tag	p.Q159*	SLC12A8_ENST00000469902.1_Nonsense_Mutation_p.Q130*|SLC12A8_ENST00000393469.4_Nonsense_Mutation_p.Q130*|SLC12A8_ENST00000314584.7_5'UTR			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	130					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						GGCCTCACCTGTCCAAACACA	0.637000													14	15					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43270090	43270090	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43270090C>T	ENST00000372585.5	+	8	1309	c.1214C>T	c.(1213-1215)aCg>aTg	p.T405M	SLC22A7_ENST00000372574.3_Missense_Mutation_p.T403M|SLC22A7_ENST00000372589.3_Missense_Mutation_p.T403M	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	405						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CGCCGCCTCACGCAAGCTGGG	0.637000													7	7					0	0	1	0	0
GLYATL2	219970	broad.mit.edu	37	11	58602079	58602079	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:58602079G>A	ENST00000287275.1	-	6	1098	c.708C>T	c.(706-708)ggC>ggT	p.G236G	GLYATL2_ENST00000532258.1_Silent_p.G236G	NM_145016.3	NP_659453.3	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	236						mitochondrion	glycine N-acyltransferase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	23		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	GCAACATGTTGCCTTGGTGTC	0.423000													11	36					0	0	1	0	0
ZC2HC1C	79696	broad.mit.edu	37	14	75538516	75538516	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:75538516C>T	ENST00000524913.1	+	2	1729	c.1240C>T	c.(1240-1242)Cgg>Tgg	p.R414W	ZC2HC1C_ENST00000439583.2_Intron|ZC2HC1C_ENST00000526748.1_Intron|ZC2HC1C_ENST00000238686.8_Intron	NM_024643.2	NP_078919.2	Q53FD0	F164C_HUMAN	zinc finger, C2HC-type containing 1C	0																	CAGCAGGATGCGGGGTTCCAA	0.577000													11	18					0	0	1	0	0
PCDHAC1	0	broad.mit.edu	37	5	140307447	140307447	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140307447G>A	ENST00000253807.2	+	1	970	c.970G>A	c.(970-972)Gct>Act	p.A324T	PCDHA7_ENST00000525929.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.A324T|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTAGCACCGCTAAACTGCT	0.567000													47	66					0	0	1	0	0
IPPK	64768	broad.mit.edu	37	9	95400457	95400457	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95400457C>T	ENST00000287996.3	-	9	1018	c.742G>A	c.(742-744)Gcc>Acc	p.A248T		NM_022755.5	NP_073592.1	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	248					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(2)|urinary_tract(1)	15						GGCCCACTGGCCAGGCCGTTG	0.637000													8	14					0	0	1	0	0
PFKM	5213	broad.mit.edu	37	12	48537872	48537872	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48537872A>G	ENST00000340802.6	+	22	2361	c.2137A>G	c.(2137-2139)Aac>Gac	p.N713D	PFKM_ENST00000547587.1_Missense_Mutation_p.N642D|PFKM_ENST00000395233.2_Missense_Mutation_p.N611D|PFKM_ENST00000359794.5_Missense_Mutation_p.N642D|PFKM_ENST00000551804.1_Missense_Mutation_p.N611D|PFKM_ENST00000312352.7_Missense_Mutation_p.N642D	NM_001166686.1	NP_001160158.1	P08237	K6PF_HUMAN	phosphofructokinase, muscle	642					fructose 6-phosphate metabolic process|glycolysis|muscle cell homeostasis	6-phosphofructokinase complex|apical plasma membrane	6-phosphofructokinase activity|ATP binding|identical protein binding|kinase binding|metal ion binding|protein C-terminus binding			NS(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						CTTCATTTTCAACCTGTACTC	0.502000													43	65					0	0	1	0	0
LONRF1	91694	broad.mit.edu	37	8	12594257	12594257	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:12594257T>C	ENST00000398246.3	-	6	1473	c.1404A>G	c.(1402-1404)ccA>ccG	p.P468P	LONRF1_ENST00000533751.1_Silent_p.P111P	NM_152271.3	NP_689484.3	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger 1	468					proteolysis		ATP-dependent peptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19				READ - Rectum adenocarcinoma(644;0.236)		TTAATTCTTCTGGAATATCAC	0.313000													46	60					0	0	1	0	0
METTL4	64863	broad.mit.edu	37	18	2544202	2544202	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:2544202G>A	ENST00000574538.1	-	8	2040	c.1265C>T	c.(1264-1266)cCg>cTg	p.P422L	METTL4_ENST00000319888.6_Intron	NM_022840.3	NP_073751.3	Q8N3J2	METL4_HUMAN	methyltransferase like 4	422					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						ACCAGCAAGCGGTGGCTTATG	0.358000													27	29					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834537	101834537	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:101834537G>A	ENST00000506729.1	-	1	183	c.12C>T	c.(10-12)ggC>ggT	p.G4G	SLCO6A1_ENST00000379810.1_Silent_p.G4G|SLCO6A1_ENST00000513675.1_Silent_p.G4G|SLCO6A1_ENST00000379807.3_Silent_p.G4G|SLCO6A1_ENST00000389019.3_Silent_p.G4G			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	4						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		GCCGGGCGACGCCTACGAACA	0.701000													53	81					0	0	1	0	0
KIT	3815	broad.mit.edu	37	4	55602953	55602953	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:55602953G>A	ENST00000288135.5	+	19	2760	c.2663G>A	c.(2662-2664)cGg>cAg	p.R888Q		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	888	Protein kinase.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GAAGGCTTCCGGATGCTCAGC	0.428000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				16	49					0	0	1	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100537606	100537606	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:100537606G>A	ENST00000268070.4	-	19	2885	c.2780C>T	c.(2779-2781)gCg>gTg	p.A927V		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	927	TSP type-1 4.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CCACTCAGACGCCTCCCAGAT	0.662000													17	28					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156617818	156617818	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156617818G>A	ENST00000329117.4	+	5	1021	c.685G>A	c.(685-687)Gat>Aat	p.D229N	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000361588.5_Missense_Mutation_p.D229N	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	229	Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGGAGACATGGATGGCTTCCC	0.532000													22	44					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599627	136599627	+	Missense_Mutation	SNP	C	C	A	rs149799182		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:136599627C>A	ENST00000531224.1	-	4	644	c.392G>T	c.(391-393)cGg>cTg	p.R131L	BCLAF1_ENST00000392348.2_Missense_Mutation_p.R129L|BCLAF1_ENST00000353331.4_Missense_Mutation_p.R129L|BCLAF1_ENST00000527759.1_Missense_Mutation_p.R129L|BCLAF1_ENST00000530767.1_Missense_Mutation_p.R131L|BCLAF1_ENST00000527536.1_Missense_Mutation_p.R131L	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	131					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding	p.R131P(1)		haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCTATATGACCGGCGAGATCT	0.448000													44	161					2.47872e-24	2.76515e-24	1	1	0
PKD2L1	9033	broad.mit.edu	37	10	102056787	102056787	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:102056787G>A	ENST00000318222.3	-	6	1517	c.1135C>T	c.(1135-1137)Ctt>Ttt	p.L379F	PKD2L1_ENST00000338519.3_Missense_Mutation_p.L304F|PKD2L1_ENST00000353274.3_Missense_Mutation_p.L379F	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	379					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		AGGTAGCGAAGCCGGTGAATG	0.517000													19	19					0	0	1	0	0
ACPL2	92370	broad.mit.edu	37	3	141011925	141011925	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:141011925C>T	ENST00000508812.1	+	5	3201	c.1294C>T	c.(1294-1296)Cgt>Tgt	p.R432C	ACPL2_ENST00000502783.1_Missense_Mutation_p.R403C|ACPL2_ENST00000504264.1_Missense_Mutation_p.R424C|ACPL2_ENST00000286353.4_Missense_Mutation_p.R441C|ACPL2_ENST00000393007.1_Missense_Mutation_p.R425C|RP11-438D8.2_ENST00000507698.1_RNA|ACPL2_ENST00000393010.2_Missense_Mutation_p.R441C			Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2	441						extracellular region	acid phosphatase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(2)	23						CCACCACAAGCGTTCTCCCAA	0.493000													33	56					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57161695	57161695	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:57161695G>A	ENST00000371244.4	+	6	717	c.651G>A	c.(649-651)gaG>gaA	p.E217E		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	217	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						TTGATGATGAGCATGTACCTA	0.433000													92	148					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15693592	15693592	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:15693592C>T	ENST00000281513.5	-	5	318	c.293G>A	c.(292-294)gGa>gAa	p.G98E	NBAS_ENST00000441750.1_Missense_Mutation_p.G98E	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	98										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						CAAAAGCTTTCCATTGCTTTT	0.299000													31	48					0	0	1	0	0
TNKS	8658	broad.mit.edu	37	8	9413926	9413926	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:9413926T>C	ENST00000310430.6	+	1	503	c.477T>C	c.(475-477)gtT>gtC	p.V159V	TNKS_ENST00000522110.1_Silent_p.V159V|RP11-375N15.2_ENST00000607598.1_RNA|TNKS_ENST00000520408.1_Silent_p.V159V	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	159					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		CGGCCGGAGTTAGCAGCACAG	0.647000													22	38					0	0	1	0	0
OR4L1	122742	broad.mit.edu	37	14	20528812	20528812	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:20528812C>T	ENST00000315683.1	+	1	609	c.609C>T	c.(607-609)agC>agT	p.S203S		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TTGCTGACAGCGGGCTGCTCT	0.433000													43	68					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179444834	179444834	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179444834G>A	ENST00000589042.1	-	318	67404	c.67180C>T	c.(67180-67182)Cgt>Tgt	p.R22394C	TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R13521C|TTN_ENST00000591111.1_Missense_Mutation_p.R20753C|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R13329C|TTN-AS1_ENST00000438095.1_RNA|RP11-171I2.2_ENST00000603521.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R19826C|TTN_ENST00000359218.5_Missense_Mutation_p.R13454C|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20753	Ig-like 116.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGCATCACGTTTTTGTACC	0.443000													35	74					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84208159	84208159	+	Silent	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:84208159A>C	ENST00000376499.3	-	15	2426	c.1362T>G	c.(1360-1362)ggT>ggG	p.G454G		NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	454					negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						GCTGCATCTGACCGTCTGCAG	0.542000													14	30					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61255918	61255918	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:61255918C>T	ENST00000344731.5	+	2	119	c.17C>T	c.(16-18)gCc>gTc	p.A6V	SERPINB13_ENST00000269489.5_Missense_Mutation_p.A6V	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	6					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						TCACTTGGCGCCGTCAGCACT	0.423000													24	41					0	0	1	0	0
TRAK1	22906	broad.mit.edu	37	3	42167092	42167092	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:42167092C>T	ENST00000327628.5	+	2	672	c.272C>T	c.(271-273)aCg>aTg	p.T91M	TRAK1_ENST00000487159.1_3'UTR	NM_001042646.2	NP_001036111.1	Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	91	HAP1 N-terminal.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						ATTGAAGAGACGTTAAAATAC	0.463000													6	83					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103067347	103067347	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:103067347G>T	ENST00000264260.2	+	11	1839	c.1250G>T	c.(1249-1251)tGg>tTg	p.W417L	IL18RAP_ENST00000409369.1_Missense_Mutation_p.W275L	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	417	TIR.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						TATGCAAAATGGAGCTCTTTT	0.343000													4	94					0.00024832	0.000253518	1	1	0
KALRN	8997	broad.mit.edu	37	3	124385389	124385389	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:124385389C>T	ENST00000360013.3	+	46	6563	c.6436C>T	c.(6436-6438)Cgc>Tgc	p.R2146C	KALRN_ENST00000393496.1_Missense_Mutation_p.R487C|KALRN_ENST00000428018.2_Missense_Mutation_p.R417C|KALRN_ENST00000459915.1_Missense_Mutation_p.R238C|KALRN_ENST00000291478.4_Missense_Mutation_p.R449C	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2145	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CAAAGAGAGGCGCGTGTTCCT	0.547000													21	31					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4433428	4433428	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4433428C>T	ENST00000301280.5	+	13	2666	c.2565C>T	c.(2563-2565)agC>agT	p.S855S		NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	855	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGTGGCAGCGTCCCCTCCA	0.642000								Chromatin Structure					21	33					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22272129	22272129	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:22272129G>A	ENST00000594947.1	+	4	1721	c.1577G>A	c.(1576-1578)cGt>cAt	p.R526H		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	526				R -> T (in Ref. 1; AAD20957).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R526H(1)		haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCTTTTAATCGTTTCTCATAC	0.398000													18	30					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62648833	62648833	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:62648833T>C	ENST00000337910.5	-	6	930	c.593A>G	c.(592-594)gAt>gGt	p.D198G	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.D198G	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	198	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					GTCAAACACATCCTTGATACC	0.468000													63	104					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43319589	43319589	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:43319589C>T	ENST00000321925.4	+	8	1140	c.908C>T	c.(907-909)gCg>gTg	p.A303V	SLC14A1_ENST00000586142.1_Missense_Mutation_p.A303V|RP11-116O18.3_ENST00000589510.1_RNA|SLC14A1_ENST00000535474.1_Missense_Mutation_p.A171V|SLC14A1_ENST00000502059.2_Missense_Mutation_p.A195V|RP11-116O18.3_ENST00000586213.1_RNA|SLC14A1_ENST00000589700.1_Missense_Mutation_p.R254C|SLC14A1_ENST00000402943.2_Missense_Mutation_p.A198V|SLC14A1_ENST00000591541.1_Missense_Mutation_p.A7V|SLC14A1_ENST00000415427.3_Missense_Mutation_p.A359V|SLC14A1_ENST00000436407.3_Missense_Mutation_p.A359V	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	303						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						ATGTTCATGGCGCTCACCTGG	0.547000													18	36					0	0	1	0	0
PTDSS2	81490	broad.mit.edu	37	11	489597	489597	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:489597G>A	ENST00000308020.5	+	10	1155	c.979G>A	c.(979-981)Gca>Aca	p.A327T		NM_030783.1	NP_110410.1	Q9BVG9	PTSS2_HUMAN	phosphatidylserine synthase 2	327						integral to membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(1)	9		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;2.76e-26)|Epithelial(43;2.56e-25)|OV - Ovarian serous cystadenocarcinoma(40;7.54e-20)|BRCA - Breast invasive adenocarcinoma(625;8.76e-05)|Lung(200;0.0407)|LUSC - Lung squamous cell carcinoma(625;0.0735)	Phosphatidylserine(DB00144)	GTTCCTGTTGGCAGAACTGAA	0.647000													5	3					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50901310	50901310	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50901310C>T	ENST00000380817.2	-	17	2140	c.1957G>A	c.(1957-1959)Gcc>Acc	p.A653T	SBF1_ENST00000348911.6_Missense_Mutation_p.A654T|SBF1_ENST00000390679.3_Missense_Mutation_p.A653T	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	653					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CGGCAGAAGGCTGTGACCAGA	0.657000													8	16					0	0	1	0	0
NAT8L	339983	broad.mit.edu	37	4	2065672	2065672	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2065672G>A	ENST00000423729.2	+	3	727	c.727G>A	c.(727-729)Gcg>Acg	p.A243T	NAT8L_ENST00000331662.3_Missense_Mutation_p.A75T	NM_178557.3	NP_848652.2	Q8N9F0	NAT8L_HUMAN	N-acetyltransferase 8-like (GCN5-related, putative)	243	N-acetyltransferase.					integral to membrane|microsome|mitochondrial membrane|rough endoplasmic reticulum membrane	aspartate N-acetyltransferase activity			haematopoietic_and_lymphoid_tissue(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(23;0.0315)			CAACTACTCCGCGGTGGTGCT	0.657000													12	16					0	0	1	0	0
DPM1	8813	broad.mit.edu	37	20	49552742	49552742	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:49552742G>A	ENST00000371582.4	-	9	733	c.702C>T	c.(700-702)taC>taT	p.Y234Y	DPM1_ENST00000466152.1_5'UTR|DPM1_ENST00000371588.5_Silent_p.Y207Y|RP5-914P20.5_ENST00000558899.2_RNA|DPM1_ENST00000371583.5_Silent_p.Y202Y			O60762	DPM1_HUMAN	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit	207					C-terminal protein lipidation|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|protein N-linked glycosylation via asparagine|protein O-linked mannosylation	dolichol-phosphate-mannose synthase complex|endoplasmic reticulum membrane|membrane fraction	dolichyl-phosphate beta-D-mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	7						TCTGGAAGACGTAGCCTTTAG	0.333000													21	42					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76412444	76412444	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:76412444C>A	ENST00000370014.3	+	19	2991	c.2372C>A	c.(2371-2373)gCt>gAt	p.A791D	SENP6_ENST00000370010.2_Missense_Mutation_p.A784D|SENP6_ENST00000447266.2_Missense_Mutation_p.A791D|SENP6_ENST00000541192.1_Intron	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6	791	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				CATGAAAATGCTGTCATACAG	0.383000													24	47					1.9806e-07	2.07755e-07	1	1	0
SLC18A2	6571	broad.mit.edu	37	10	119029690	119029690	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:119029690G>A	ENST00000298472.5	+	14	1438	c.1295G>A	c.(1294-1296)gGg>gAg	p.G432E	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	432					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TTTTGTATGGGGTATGCTATA	0.428000													57	109					0	0	1	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88924393	88924393	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:88924393A>G	ENST00000277141.6	-	21	3858	c.1434T>C	c.(1432-1434)atT>atC	p.I478I	ZCCHC6_ENST00000375961.2_Intron|ZCCHC6_ENST00000375960.2_Silent_p.I953I|ZCCHC6_ENST00000375963.3_Silent_p.I1189I|ZCCHC6_ENST00000375957.1_Intron			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	1189					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						GAAGGACAGGAATGACTGGTG	0.398000													25	40					0	0	1	0	0
OR5V1	81696	broad.mit.edu	37	6	29323599	29323599	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:29323599G>A	ENST00000377154.1	-	4	673	c.374C>T	c.(373-375)gCa>gTa	p.A125V	OR5V1_ENST00000543825.1_Missense_Mutation_p.A125V			Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V, member 1	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(3)|large_intestine(3)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						ATTGCAGATTGCAATGTAACG	0.418000													8	46					0	0	1	0	0
HGS	9146	broad.mit.edu	37	17	79663968	79663968	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79663968T>C	ENST00000329138.4	+	18	1957	c.1822T>C	c.(1822-1824)Tac>Cac	p.Y608H		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	608	Gln-rich.|Interaction with NF2.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			GCACGGCGTGTACATGAGCCA	0.687000													13	26					0	0	1	0	0
NT5DC1	221294	broad.mit.edu	37	6	116432053	116432053	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:116432053G>A	ENST00000319550.4	+	4	380	c.298G>A	c.(298-300)Gca>Aca	p.A100T		NM_152729.2	NP_689942.2	Q5TFE4	NT5D1_HUMAN	5'-nucleotidase domain containing 1	100							hydrolase activity|metal ion binding			large_intestine(2)|lung(2)|prostate(2)|skin(1)|stomach(1)	8		all_cancers(87;0.00367)|all_epithelial(87;0.00449)|Colorectal(196;0.0469)		all cancers(137;0.0327)|OV - Ovarian serous cystadenocarcinoma(136;0.0445)|GBM - Glioblastoma multiforme(226;0.0719)|Epithelial(106;0.112)		AGAGGTGCTGGCAGAGGCATA	0.517000													7	39					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43076730	43076730	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43076730C>T	ENST00000428554.2	+	17	2608	c.1465C>T	c.(1465-1467)Cga>Tga	p.R489*	CCDC30_ENST00000342022.4_Nonsense_Mutation_p.R489*|CCDC30_ENST00000390640.4_Nonsense_Mutation_p.R278*|CCDC30_ENST00000507855.1_Nonsense_Mutation_p.R278*|CCDC30_ENST00000340612.4_Nonsense_Mutation_p.R489*			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	489										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						AGAATATTTGCGATTATTGAA	0.373000													12	16					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34147037	34147037	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:34147037C>A	ENST00000389232.4	+	98	14001	c.13931C>A	c.(13930-13932)gCt>gAt	p.A4644D	RYR3_ENST00000415757.3_Missense_Mutation_p.A4639D|RYR3_ENST00000559917.1_3'UTR	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	4644					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTCTTTGCTGCTCACCTATTG	0.453000													36	64					6.29468e-14	6.85409e-14	1	1	0
NDRG1	10397	broad.mit.edu	37	8	134292492	134292492	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:134292492G>A	ENST00000414097.2	-	3	949	c.82C>T	c.(82-84)Caa>Taa	p.Q28*	NDRG1_ENST00000518066.1_Intron|NDRG1_ENST00000518176.1_Intron|NDRG1_ENST00000522476.1_Intron|NDRG1_ENST00000323851.7_Nonsense_Mutation_p.Q28*|NDRG1_ENST00000537882.1_5'UTR|NDRG1_ENST00000354944.5_Nonsense_Mutation_p.Q28*	NM_001135242.1	NP_001128714.1	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	28					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding		NDRG1/ERG(5)	endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(4)|prostate(1)|skin(1)	17	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			TCAAACTCTTGCAGGAGGCCG	0.403000			T	ERG	prostate								7	38					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156626136	156626136	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156626136C>T	ENST00000329117.4	+	9	2341	c.2005C>T	c.(2005-2007)Cgc>Tgc	p.R669C	RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	669	EGF-like.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding	p.R669C(1)		cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGAAGGGGTCCGCTGCCTATG	0.642000													31	40					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3614738	3614738	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3614738C>T	ENST00000301749.7	-	0	605				NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000603507.1_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CAGGGCCTTGCGGTGCCTCTG	0.677000													10	11					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113168745	113168745	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:113168745G>T	ENST00000401783.2	-	38	9471	c.9135C>A	c.(9133-9135)acC>acA	p.T3045T	SVEP1_ENST00000297826.5_Silent_p.T971T|SVEP1_ENST00000374469.1_Silent_p.T3022T	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3045	Sushi 27.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CGGCTTCACAGGTGATTTCAG	0.483000													14	28					1.49906e-05	1.54943e-05	1	1	0
CRK	1398	broad.mit.edu	37	17	1339932	1339932	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1339932C>T	ENST00000300574.2	-	2	899	c.759G>A	c.(757-759)aaG>aaA	p.K253K	CRK_ENST00000574295.1_Intron|CRK_ENST00000572145.1_Intron|CRK_ENST00000398970.5_Intron	NM_016823.3	NP_058431.2	P46108	CRK_HUMAN	v-crk avian sarcoma virus CT10 oncogene homolog	253	SH3 2.				actin cytoskeleton organization|activation of MAPKK activity|blood coagulation|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of transcription from RNA polymerase II promoter	cytosol|endosome|nucleus|plasma membrane	protein binding|SH2 domain binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)	9				UCEC - Uterine corpus endometrioid carcinoma (25;0.083)		CCAAGGCTGTCTTGTCGTAGG	0.527000													17	70					0	0	1	0	0
TBC1D15	64786	broad.mit.edu	37	12	72278612	72278612	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:72278612G>A	ENST00000550746.1	+	5	429	c.365G>A	c.(364-366)gGg>gAg	p.G122E	TBC1D15_ENST00000393309.3_Intron|TBC1D15_ENST00000319106.8_Missense_Mutation_p.G130E|TBC1D15_ENST00000485960.2_Missense_Mutation_p.G122E	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	122							protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CATAGAAATGGGAAAAGCAAA	0.388000													10	22					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11118668	11118668	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11118668G>A	ENST00000358026.2	+	14	2376	c.2092G>A	c.(2092-2094)Gtc>Atc	p.V698I	SMARCA4_ENST00000589677.1_Missense_Mutation_p.V698I|SMARCA4_ENST00000541122.2_Missense_Mutation_p.V698I|SMARCA4_ENST00000590574.1_Missense_Mutation_p.V698I|SMARCA4_ENST00000413806.3_Missense_Mutation_p.V698I|SMARCA4_ENST00000344626.4_Missense_Mutation_p.V698I|SMARCA4_ENST00000450717.3_Missense_Mutation_p.V698I|SMARCA4_ENST00000429416.3_Missense_Mutation_p.V698I|SMARCA4_ENST00000444061.3_Missense_Mutation_p.V698I	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	698					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CAGCGATGACGTCTCTGAGGT	0.602000			"""F, N, Mis"""		NSCLC								7	13					0	0	1	0	0
PPAN	56342	broad.mit.edu	37	19	10225358	10225358	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10225358A>G	ENST00000556468.1	+	13	2356	c.2329A>G	c.(2329-2331)Aat>Gat	p.N777D	P2RY11_ENST00000321826.4_Missense_Mutation_p.N357D|PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.N777D|PPAN-P2RY11_ENST00000428358.1_3'UTR					peter pan homolog (Drosophila)											endometrium(3)|liver(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			CCTGCCCCTCAATGCCACAGC	0.657000													3	29					0	0	1	0	0
TMEM161A	54929	broad.mit.edu	37	19	19231627	19231627	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19231627T>C	ENST00000450333.2	-	9	861	c.824A>G	c.(823-825)tAc>tGc	p.Y275C	TMEM161A_ENST00000587583.2_Missense_Mutation_p.Y353C|TMEM161A_ENST00000162044.9_Missense_Mutation_p.Y378C	NM_001256766.1	NP_001243695.1	Q9NX61	T161A_HUMAN	transmembrane protein 161A	378					cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			CGGCGTCAGGTACTGCAAGCT	0.617000													12	29					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13941491	13941491	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13941491T>C	ENST00000254323.2	+	13	2786	c.2597T>C	c.(2596-2598)gTc>gCc	p.V866A	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.V700A	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	866							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			TCTGCCATCGTCCCCCTCATC	0.652000													43	70					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	18022110	18022110	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:18022110T>C	ENST00000262608.8	+	15	2215	c.2215T>C	c.(2215-2217)Tat>Cat	p.Y739H	CECR2_ENST00000400573.4_Missense_Mutation_p.Y738H|CECR2_ENST00000400585.2_Missense_Mutation_p.Y597H	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	780					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		CAGCCATATGTATCGATCGTA	0.562000													10	16					0	0	1	0	0
TUBA8	51807	broad.mit.edu	37	22	18613794	18613794	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:18613794A>G	ENST00000330423.3	+	5	1314	c.1241A>G	c.(1240-1242)gAa>gGa	p.E414G	TUBA8_ENST00000316027.6_Missense_Mutation_p.E348G	NM_018943.2	NP_061816.1	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	414					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	14						GAGGGGATGGAAGAAGGAGAA	0.542000													31	41					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23528663	23528663	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23528663C>T	ENST00000262710.1	-	19	4047	c.3720G>A	c.(3718-3720)gaG>gaA	p.E1240E	ACIN1_ENST00000338631.6_Silent_p.E513E|ACIN1_ENST00000397341.3_Silent_p.E482E|ACIN1_ENST00000557515.1_Silent_p.E481E|ACIN1_ENST00000605057.1_Silent_p.E1182E|ACIN1_ENST00000457657.1_Silent_p.E1200E|ACIN1_ENST00000357481.2_Silent_p.E482E|ACIN1_ENST00000555053.1_Silent_p.E1227E	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1240	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GTTCGGCCCGCTCTGCCTCTT	0.592000													19	34					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52632448	52632448	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:52632448G>A	ENST00000399231.3	-	32	4427	c.4184C>T	c.(4183-4185)gCc>gTc	p.A1395V	MYO5A_ENST00000356338.6_Missense_Mutation_p.A1368V|MYO5A_ENST00000358212.6_Missense_Mutation_p.A1395V|MYO5A_ENST00000399233.2_Missense_Mutation_p.A1392V|MYO5A_ENST00000553916.1_Missense_Mutation_p.A1368V	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1395					actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTCAATGCGGGCCTCTGGGGG	0.622000													10	59					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104128502	104128502	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:104128502C>T	ENST00000369983.3	+	23	3143	c.2883C>T	c.(2881-2883)tgC>tgT	p.C961C		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	961					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		ACAGGAAGTGCGCCATGATCT	0.537000													16	31					0	0	1	0	0
GNA11	2767	broad.mit.edu	37	19	3119007	3119007	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3119007G>A	ENST00000078429.4	+	5	933	c.691G>A	c.(691-693)Gcc>Acc	p.A231T	AC005262.3_ENST00000587701.1_RNA|GNA11_ENST00000586180.1_3'UTR	NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	231					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		GTTTCTCGTCGCCCTCAGCGA	0.632000			Mis		uveal melanoma								32	49					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13611972	13611972	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:13611972G>A	ENST00000404922.3	+	2	236	c.117G>A	c.(115-117)ccG>ccA	p.P39P	FBLN2_ENST00000535798.1_Silent_p.P65P|FBLN2_ENST00000492059.1_Silent_p.P39P|FBLN2_ENST00000295760.7_Silent_p.P39P	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	39	N.|Subdomain NA (Cys-rich).					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			TGGAGTGCCCGCCGCTGGAGA	0.706000													5	6					0	0	1	0	0
PDE9A	5152	broad.mit.edu	37	21	44152048	44152048	+	Missense_Mutation	SNP	G	G	A	rs139833833		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:44152048G>A	ENST00000291539.6	+	5	491	c.431G>A	c.(430-432)cGc>cAc	p.R144H	PDE9A_ENST00000398236.3_Intron|PDE9A_ENST00000380328.2_Intron|PDE9A_ENST00000335512.4_Intron|PDE9A_ENST00000398232.3_Missense_Mutation_p.R77H|PDE9A_ENST00000398227.3_Intron|PDE9A_ENST00000349112.3_Intron|PDE9A_ENST00000398229.3_Intron|PDE9A_ENST00000328862.6_Missense_Mutation_p.R118H|PDE9A_ENST00000398225.3_Missense_Mutation_p.R103H|PDE9A_ENST00000398234.3_Intron|PDE9A_ENST00000539837.1_Intron|PDE9A_ENST00000398224.3_Intron|PDE9A_ENST00000335440.6_Intron|PDE9A_ENST00000470987.1_Intron	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	144					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						GAAGGCCAGCGCATCCCTCCA	0.632000													5	2					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204403686	204403686	+	Silent	SNP	G	G	A	rs150291272		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:204403686G>A	ENST00000367187.3	-	25	4123	c.3567C>T	c.(3565-3567)taC>taT	p.Y1189Y	RP11-739N20.2_ENST00000443515.1_RNA|PIK3C2B_ENST00000424712.2_Silent_p.Y1161Y	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	1189	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TGCCCAAGACGTACGTGGCCA	0.547000													4	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179408999	179408999	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179408999G>A	ENST00000589042.1	-	345	96181	c.95957C>T	c.(95956-95958)gCt>gTt	p.A31986V	TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.A23113V|TTN_ENST00000591111.1_Missense_Mutation_p.A30345V|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.A22921V|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.A29418V|TTN_ENST00000359218.5_Missense_Mutation_p.A23046V|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30345	Ig-like 142.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTCACGGCAGCAACTCTGAA	0.423000													22	28					0	0	1	0	0
LMTK2	22853	broad.mit.edu	37	7	97821546	97821546	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:97821546C>T	ENST00000297293.5	+	11	2062	c.1769C>T	c.(1768-1770)aCg>aTg	p.T590M		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	590					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					TCCCAGCTCACGGCGCTCAGG	0.512000													4	31					0	0	1	0	0
SESN1	27244	broad.mit.edu	37	6	109321872	109321872	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:109321872G>A	ENST00000436639.2	-	4	1296	c.551C>T	c.(550-552)gCg>gTg	p.A184V	SESN1_ENST00000356644.7_Missense_Mutation_p.A125V|SESN1_ENST00000302071.2_Missense_Mutation_p.A59V	NM_014454.2	NP_055269.1	Q9Y6P5	SESN1_HUMAN	sestrin 1	125					cell cycle arrest|negative regulation of cell proliferation|response to DNA damage stimulus	nucleus				cervix(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	10		all_cancers(87;6.45e-05)|Acute lymphoblastic leukemia(125;3.55e-10)|all_hematologic(75;1.68e-07)|all_epithelial(87;0.0106)|Colorectal(196;0.0637)		Epithelial(106;0.0014)|BRCA - Breast invasive adenocarcinoma(108;0.00146)|all cancers(137;0.0031)|OV - Ovarian serous cystadenocarcinoma(136;0.0117)		ATGTCTTGCCGCAGCCTTAAA	0.348000													21	33					0	0	1	0	0
OR51B4	79339	broad.mit.edu	37	11	5322273	5322273	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5322273G>A	ENST00000380224.1	-	1	953	c.904C>T	c.(904-906)Cgc>Tgc	p.R302C	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAAATAGGCGAATAATGCTT	0.433000													14	19					0	0	1	0	0
CDC45	8318	broad.mit.edu	37	22	19502541	19502541	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19502541C>T	ENST00000407835.1	+	16	1666	c.1410C>T	c.(1408-1410)agC>agT	p.S470S	CDC45_ENST00000437685.2_Silent_p.S502S|CDC45_ENST00000263201.1_Silent_p.S470S|CDC45_ENST00000404724.3_Silent_p.S424S			O75419	CDC45_HUMAN	cell division cycle 45	470					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding	p.S470R(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	19						GCCTGCTCAGCAAACACCTGC	0.602000													9	16					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527522	23527522	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:23527522C>A	ENST00000296682.3	+	11	2507	c.2325C>A	c.(2323-2325)ccC>ccA	p.P775P		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	775					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GGGAGAAGCCCTATGTCTGCA	0.577000										HNSCC(3;0.000094)			51	56					1.46156e-29	1.63704e-29	1	1	0
VPS13D	55187	broad.mit.edu	37	1	12371652	12371652	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12371652G>A	ENST00000358136.3	+	28	6922	c.6792G>A	c.(6790-6792)cgG>cgA	p.R2264R	VPS13D_ENST00000356315.4_Silent_p.R2264R	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2264					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AATTTATGCGGCCTTATGATT	0.443000													47	76					0	0	1	0	0
STAG3	10734	broad.mit.edu	37	7	99779743	99779743	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99779743C>T	ENST00000426455.1	+	3	554	c.147C>T	c.(145-147)gaC>gaT	p.D49D	STAG3_ENST00000394018.2_Silent_p.D49D|STAG3_ENST00000317296.5_Silent_p.D49D			Q9UJ98	STAG3_HUMAN	stromal antigen 3	49					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(11)|lung(30)|ovary(5)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	66	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGATGAAGACACTGACTTTG	0.393000													31	23					0	0	1	0	0
PCDHGA2	0	broad.mit.edu	37	5	140720865	140720865	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140720865C>T	ENST00000394576.2	+	1	2327	c.2327C>T	c.(2326-2328)gCg>gTg	p.A776V	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCAACTATGCGGACACGCTC	0.527000													46	85					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102509648	102509648	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:102509648C>A	ENST00000321521.9	+	21	3074	c.2501C>A	c.(2500-2502)tCt>tAt	p.S834Y	PPIP5K2_ENST00000414217.1_Missense_Mutation_p.S834Y|PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000358359.3_Missense_Mutation_p.S834Y			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	834					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TCTTTGCTGTCTATTCTTCGC	0.308000													25	27					1.66031e-10	1.77558e-10	1	1	0
LPHN2	23266	broad.mit.edu	37	1	82450947	82450947	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:82450947G>A	ENST00000370728.1	+	23	4049	c.3404G>A	c.(3403-3405)cGt>cAt	p.R1135H	LPHN2_ENST00000359929.3_Missense_Mutation_p.R1122H|LPHN2_ENST00000370730.1_Missense_Mutation_p.R1135H|LPHN2_ENST00000319517.6_Missense_Mutation_p.R1122H|LPHN2_ENST00000335786.5_Missense_Mutation_p.R1135H|LPHN2_ENST00000370723.1_Missense_Mutation_p.R1137H|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000394879.1_Missense_Mutation_p.R1137H|LPHN2_ENST00000370721.1_Missense_Mutation_p.R1060H|LPHN2_ENST00000370713.1_Intron|LPHN2_ENST00000370727.1_Missense_Mutation_p.R1150H|LPHN2_ENST00000370717.2_Missense_Mutation_p.R1150H|LPHN2_ENST00000370715.1_Missense_Mutation_p.R1122H|LPHN2_ENST00000271029.4_Missense_Mutation_p.R1150H|LPHN2_ENST00000370725.1_Missense_Mutation_p.R1150H			O95490	LPHN2_HUMAN	latrophilin 2	1135					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TAATAGAGTCGTATAAGAAGA	0.323000													9	15					0	0	1	0	0
INPP5K	51763	broad.mit.edu	37	17	1401384	1401384	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1401384C>T	ENST00000406424.4	-	10	1441	c.581G>A	c.(580-582)cGc>cAc	p.R194H	INPP5K_ENST00000397335.3_Missense_Mutation_p.R178H|INPP5K_ENST00000421807.2_Missense_Mutation_p.R270H|INPP5K_ENST00000542125.1_Missense_Mutation_p.R174H|INPP5K_ENST00000320345.6_Missense_Mutation_p.R194H	NM_001135642.1	NP_001129114.1	Q9BT40	INP5K_HUMAN	inositol polyphosphate-5-phosphatase K	270	Catalytic (Potential).				actin cytoskeleton organization	cytosol|endoplasmic reticulum|membrane fraction|neuron projection|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol bisphosphate phosphatase activity|inositol trisphosphate phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|lipid phosphatase activity|protein binding			endometrium(1)|large_intestine(7)|lung(3)|skin(1)	12						CCACAGGATGCGATCGGTCCA	0.582000													44	76					0	0	1	0	0
NUDT14	256281	broad.mit.edu	37	14	105643040	105643040	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105643040G>A	ENST00000392568.2	-	4	352	c.259C>T	c.(259-261)Cgg>Tgg	p.R87W	RP11-44N21.4_ENST00000548203.1_RNA	NM_177533.4	NP_803877.2	O95848	NUD14_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 14	87	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity	p.R87G(1)		cervix(2)|endometrium(1)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	14		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TGTAGCTCCCGAGGCCCGTCC	0.667000										HNSCC(42;0.11)			16	25					0	0	1	0	0
CABP1	9478	broad.mit.edu	37	12	121098077	121098077	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:121098077G>A	ENST00000453000.1	+	3	1084	c.572G>A	c.(571-573)cGc>cAc	p.R191H	CABP1_ENST00000316803.3_Missense_Mutation_p.R255H|CABP1_ENST00000288616.3_Missense_Mutation_p.R112H|CABP1_ENST00000351200.2_Missense_Mutation_p.R52H			Q9NZU7	CABP1_HUMAN	calcium binding protein 1	255						cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)	9	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AACTGCATGCGCACCATGGGC	0.572000													4	25					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154863323	154863323	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:154863323C>T	ENST00000287907.2	+	1	1290	c.714C>T	c.(712-714)agC>agT	p.S238S		NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	238						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		AGACCAATAGCGTCTCACCCA	0.552000													8	18					0	0	1	0	0
PTPN7	5778	broad.mit.edu	37	1	202128602	202128602	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:202128602G>A	ENST00000367279.4	-	1	517	c.46C>T	c.(46-48)Cgg>Tgg	p.R16W	PTPN7_ENST00000309017.3_Intron|PTPN7_ENST00000544762.1_Intron|PTPN7_ENST00000308986.5_Intron|PTPN7_ENST00000543735.1_Intron	NM_080588.2	NP_542155.1	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type 7	0						cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|soft_tissue(1)|urinary_tract(1)	13						AGGGCCCTCCGCTGCTGTTCT	0.637000													10	18					0	0	1	0	0
MLLT1	4298	broad.mit.edu	37	19	6222297	6222297	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6222297C>T	ENST00000252674.7	-	6	1108	c.945G>A	c.(943-945)tcG>tcA	p.S315S		NM_005934.3	NP_005925.2	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	315					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|skin(2)	17						AGGTGCGGGGCGAGGTGCCTG	0.667000			T	MLL	AL								8	17					0	0	1	0	0
NOSIP	0	broad.mit.edu	37	19	50062167	50062167	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50062167G>A	ENST00000391853.3	-	5	396	c.245C>T	c.(244-246)gCc>gTc	p.A82V	NOSIP_ENST00000596358.1_Missense_Mutation_p.A82V|NOSIP_ENST00000339093.3_Missense_Mutation_p.A82V	NM_015953.3	NP_057037.1	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	82					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|skin(2)|urinary_tract(1)	11		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		CATCTGCCGGGCAATCTCCTT	0.562000													106	187					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81372379	81372379	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:81372379C>T	ENST00000555265.1	-	5	656	c.281G>A	c.(280-282)cGt>cAt	p.R94H	CEP128_ENST00000281129.3_Missense_Mutation_p.R94H|CEP128_ENST00000327841.2_Missense_Mutation_p.R34H|CEP128_ENST00000216517.6_Missense_Mutation_p.R94H			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	94						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						TCTCAATAAACGTTGACTCCG	0.368000													18	48					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49690940	49690940	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49690940C>T	ENST00000296452.4	+	5	4065	c.3951C>T	c.(3949-3951)ctC>ctT	p.L1317L		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1317					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCACCCAGCTCGCTGCCCCTG	0.547000													14	32					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18562759	18562759	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:18562759G>A	ENST00000399799.1	-	21	3464	c.2524C>T	c.(2524-2526)Cta>Tta	p.L842L		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	842	Glu-rich.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					TGATCTTGTAGCTCCCGCATC	0.353000													31	32					0	0	1	0	0
RBL1	5933	broad.mit.edu	37	20	35690594	35690594	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:35690594C>T	ENST00000373664.3	-	8	1042	c.976G>A	c.(976-978)Gca>Aca	p.A326T	RBL1_ENST00000344359.3_Missense_Mutation_p.A326T	NM_002895.2	NP_002886.2	P28749	RBL1_HUMAN	retinoblastoma-like 1 (p107)	326				Missing (in Ref. 8; AA sequence).	cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				TCCTCTTCTGCGTCTGCTCCC	0.413000													7	51					0	0	1	0	0
FTCD	10841	broad.mit.edu	37	21	47556899	47556899	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:47556899C>T	ENST00000397748.1	-	14	1651	c.1608G>A	c.(1606-1608)acG>acA	p.T536T	FTCD_ENST00000498355.2_5'UTR|FTCD_ENST00000359679.2_Silent_p.T536T|FTCD_ENST00000291670.5_3'UTR|FTCD_ENST00000397746.3_3'UTR|FTCD_ENST00000355384.2_3'UTR|FTCD_ENST00000397743.1_3'UTR			O95954	FTCD_HUMAN	formimidoyltransferase cyclodeaminase	43	Cyclodeaminase/cyclohydrolase (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			endometrium(1)|large_intestine(2)|lung(9)|pancreas(1)|prostate(3)|skin(3)	19	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CCTCCCGCACCGTCACTCCTG	0.657000													9	1					0	0	1	0	0
MTAP	4507	broad.mit.edu	37	9	21854832	21854832	+	Missense_Mutation	SNP	C	C	T	rs143080527	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:21854832C>T	ENST00000380172.4	+	6	859	c.653C>T	c.(652-654)gCg>gTg	p.A218V	MTAP_ENST00000460874.2_Missense_Mutation_p.A235V|MTAP_ENST00000580900.1_Missense_Mutation_p.A218V|RP11-145E5.5_ENST00000404796.2_Intron	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase	218				A -> G (in Ref. 2; AAG38871/AAR24607).	nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	ATCGCCATGGCGACAGATTAT	0.493000													18	24					0	0	1	0	0
PBX1	5087	broad.mit.edu	37	1	164761813	164761813	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:164761813C>T	ENST00000420696.2	+	3	536	c.348C>T	c.(346-348)ggC>ggT	p.G116G	PBX1_ENST00000367897.1_Silent_p.G116G|PBX1_ENST00000540246.1_Silent_p.G11G|PBX1_ENST00000540236.1_Silent_p.G116G|PBX1_ENST00000559240.1_Silent_p.G116G|PBX1_ENST00000560641.1_Silent_p.G11G|PBX1_ENST00000401534.1_Silent_p.G116G	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	116					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						TAGCGGAAGGCGTGGCGGGGC	0.627000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								5	28					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74672658	74672658	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:74672658C>T	ENST00000253159.8	+	30	5458	c.5260C>T	c.(5260-5262)Ctt>Ttt	p.L1754F	ZNF236_ENST00000320610.9_Missense_Mutation_p.L1756F	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1754					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCATTGCACGCTTTGTGAGAA	0.527000													38	63					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55537593	55537593	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55537593G>A	ENST00000294383.6	-	67	7693	c.7694C>T	c.(7693-7695)aCg>aTg	p.T2565M	USP24_ENST00000484447.1_5'UTR|USP24_ENST00000407756.1_Missense_Mutation_p.T2405M	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	2565					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						ATACGCTAACGTGTCCTGCAG	0.493000											OREG0013507	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	5					0	0	1	0	0
CYB5R4	51167	broad.mit.edu	37	6	84634191	84634191	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:84634191C>T	ENST00000369681.4	+	10	834	c.694C>T	c.(694-696)Cgg>Tgg	p.R232W		NM_016230.3	NP_057314.2	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	232	CS.				cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	23		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		CTTTTCAGTGCGGGTTGTTGA	0.333000													22	34					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39225883	39225883	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:39225883G>A	ENST00000340369.3	-	2	5282	c.5054C>T	c.(5053-5055)aCt>aTt	p.T1685I	XIRP1_ENST00000421646.1_Missense_Mutation_p.T368I|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1685	Interaction with FLNC.						actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AAAGCTGGGAGTCTCTAGAGG	0.532000													32	59					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60689317	60689317	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:60689317G>A	ENST00000335712.6	-	4	957	c.730C>T	c.(730-732)Cca>Tca	p.P244S	BCL11A_ENST00000537768.1_Intron|BCL11A_ENST00000356842.4_Missense_Mutation_p.P244S|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000358510.4_Missense_Mutation_p.P210S|BCL11A_ENST00000538214.1_Missense_Mutation_p.P210S	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	244					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ACTGATCCTGGTATTCTTAGC	0.542000			T	IGH@	B-CLL								8	15					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196765102	196765102	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:196765102C>T	ENST00000312428.6	-	28	4552	c.4452G>A	c.(4450-4452)acG>acA	p.T1484T		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1484	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ACAAGCGATACGTAGCCACAA	0.458000													39	63					0	0	1	0	0
INSR	0	broad.mit.edu	37	19	7166397	7166397	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7166397C>T	ENST00000341500.5	-	8	1668	c.1629G>A	c.(1627-1629)acG>acA	p.T543T	INSR_ENST00000302850.5_Silent_p.T543T	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	543					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGTCGAACTCCGTCACATTCT	0.537000													13	10					0	0	1	0	0
CTC-490E21.12	0	broad.mit.edu	37	19	41307260	41307260	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41307260C>T	ENST00000601627.1	+	1	59	c.59C>T	c.(58-60)aCg>aTg	p.T20M	RAB4B-EGLN2_ENST00000594136.1_3'UTR|EGLN2_ENST00000406058.2_Silent_p.D261D|EGLN2_ENST00000303961.4_Silent_p.D261D|EGLN2_ENST00000593726.1_Silent_p.D261D																							CCCATGTGGACGCCGTCATCC	0.657000													9	16					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43992576	43992576	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:43992576G>A	ENST00000282406.4	+	30	4431	c.4321G>A	c.(4321-4323)Gcc>Acc	p.A1441T		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1441	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCTTTTGATCGCCAGTTACAT	0.453000													6	49					0	0	1	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41626154	41626154	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:41626154C>T	ENST00000216237.5	+	17	2175	c.2017C>T	c.(2017-2019)Cgt>Tgt	p.R673C	CHADL_ENST00000216241.9_Intron	NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	673					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CATTGCTGTGCGTGTGAAGGA	0.607000													9	42					0	0	1	0	0
CCNT2	905	broad.mit.edu	37	2	135712081	135712081	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:135712081A>G	ENST00000264157.5	+	9	2086	c.2056A>G	c.(2056-2058)Aaa>Gaa	p.K686E	CCNT2_ENST00000537343.1_Missense_Mutation_p.E477G|CCNT2_ENST00000295238.6_Missense_Mutation_p.E652G	NM_001241.3|NM_058241.2	NP_001232.1|NP_490595.1	O60583	CCNT2_HUMAN	cyclin T2	686					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein kinase binding			endometrium(2)|kidney(3)|large_intestine(10)|lung(6)|ovary(2)|prostate(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.107)		CACCCTCGTGAAACTGGACAA	0.507000													4	42					0	0	1	0	0
IRX3	79191	broad.mit.edu	37	16	54319369	54319369	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:54319369G>C	ENST00000329734.3	-	2	1136	c.424C>G	c.(424-426)Ctg>Gtg	p.L142V		NM_024336.2	NP_077312.2	P78415	IRX3_HUMAN	iroquois homeobox 3	142					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|soft_tissue(1)|urinary_tract(1)	14						CAGGCCTTCAGCGTGCTGGTG	0.637000													18	22					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86207816	86207816	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:86207816G>A	ENST00000394518.2	+	13	4917	c.4822G>A	c.(4822-4824)Gga>Aga	p.G1608R	RP11-815J21.4_ENST00000558980.1_RNA|AKAP13_ENST00000361243.2_Missense_Mutation_p.G1612R|AKAP13_ENST00000560579.1_3'UTR	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1608					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						AGGCTTGACAGGAGGAGCTGG	0.458000													19	67					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29618458	29618458	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:29618458G>A	ENST00000356870.3	+	15	2506	c.2396G>A	c.(2395-2397)aGc>aAc	p.S799N	PTPRU_ENST00000460170.2_Missense_Mutation_p.S799N|PTPRU_ENST00000323874.8_Missense_Mutation_p.S799N|PTPRU_ENST00000345512.3_Missense_Mutation_p.S809N|PTPRU_ENST00000415600.2_3'UTR|PTPRU_ENST00000428026.2_Missense_Mutation_p.S799N|PTPRU_ENST00000373779.3_Missense_Mutation_p.S799N	NM_133177.3	NP_573438.3	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	809	Mediates interaction with CTNNB1 (By similarity).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GTGGACCGCAGCTTCACAGAC	0.642000													20	25					0	0	1	0	0
FAM5B	0	broad.mit.edu	37	1	177250404	177250404	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:177250404C>T	ENST00000361539.4	+	8	2404	c.2092C>T	c.(2092-2094)Cgg>Tgg	p.R698W	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		698						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						AGATGCTATCCGGGACTTAAT	0.502000													32	66					0	0	1	0	0
ZNF876P	0	broad.mit.edu	37	4	248113	248113	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:248113G>A	ENST00000356347.3	+	0	937					NR_027481.1																						ATACACAGGAGCATTCATTCT	0.368000													13	36					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107834557	107834557	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:107834557C>T	ENST00000379028.3	-	17	2159	c.1689G>A	c.(1687-1689)gtG>gtA	p.V563V	NRCAM_ENST00000413765.2_Silent_p.V544V|NRCAM_ENST00000379022.4_Silent_p.V563V|NRCAM_ENST00000425651.2_Silent_p.V563V|NRCAM_ENST00000351718.4_Silent_p.V557V|NRCAM_ENST00000379024.4_Silent_p.V544V			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	563	Ig-like 6.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						ATTCAAAGGACACCATGCTCC	0.453000													32	57					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64519438	64519438	+	Nonsense_Mutation	SNP	G	G	A	rs119103255		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64519438G>A	ENST00000164139.3	-	14	2124	c.1726C>T	c.(1726-1728)Cga>Tga	p.R576*	PYGM_ENST00000462303.1_5'UTR|PYGM_ENST00000377432.3_Nonsense_Mutation_p.R488*	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	576					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	AGGAGCTGTCGTTTATATTCG	0.522000													15	34					0	0	1	0	0
XYLB	9942	broad.mit.edu	37	3	38408366	38408366	+	Splice_Site	SNP	T	T	C	rs149290		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38408366T>C	ENST00000207870.3	+	7	663		c.e7+2		XYLB_ENST00000542835.1_Splice_Site	NM_005108.3	NP_005099.2	O75191	XYLB_HUMAN	xylulokinase homolog (H. influenzae)						D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			endometrium(3)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|prostate(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		CATACGGAGGTTGGTTAAATG	0.363000													15	29					0	0	1	0	0
PNN	5411	broad.mit.edu	37	14	39647050	39647050	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:39647050G>A	ENST00000216832.4	+	6	495	c.428G>A	c.(427-429)cGg>cAg	p.R143Q	PNN_ENST00000553331.1_Silent_p.P111P	NM_002687.3	NP_002678.2	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	143	Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)|stomach(1)	27	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		TTTAGGAACCGGCGAATATTT	0.343000													108	180					0	0	1	0	0
WTIP	126374	broad.mit.edu	37	19	34984203	34984203	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:34984203C>T	ENST00000590071.2	+	4	1210	c.873C>T	c.(871-873)agC>agT	p.S291S	WTIP_ENST00000270288.6_Silent_p.S515S	NM_001080436.1	NP_001073905.1			Wilms tumor 1 interacting protein											NS(1)|large_intestine(2)|lung(1)	4	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			ACAAATGCAGCGTGTGTGGAC	0.622000													5	21					0	0	1	0	0
STRAP	11171	broad.mit.edu	37	12	16055902	16055902	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:16055902T>C	ENST00000419869.2	+	10	1356	c.1043T>C	c.(1042-1044)gTt>gCt	p.V348A	STRAP_ENST00000025399.6_Missense_Mutation_p.V361A|STRAP_ENST00000538352.1_Missense_Mutation_p.V254A	NM_007178.3	NP_009109.3	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated protein	348					mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|skin(1)	15		Hepatocellular(102;0.121)				GCTCCTGATGTTAAGGCCTGA	0.348000													36	62					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68678939	68678939	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:68678939C>T	ENST00000539224.1	+	4	537	c.481C>T	c.(481-483)Cac>Tac	p.H161Y	IGHMBP2_ENST00000255078.3_Silent_p.D193D			P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	0					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CCTGCCTGGACACCTCCCAGA	0.547000													10	15					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3430395	3430395	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:3430395T>C	ENST00000336727.3	+	16	4426	c.3522T>C	c.(3520-3522)atT>atC	p.I1174I	RGS12_ENST00000344733.5_Silent_p.I1174I|RGS12_ENST00000382788.3_Silent_p.I1174I|RGS12_ENST00000338806.4_Silent_p.I526I|RGS12_ENST00000538395.1_Intron|RGS12_ENST00000306648.7_Intron	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1174						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTGCAAAGATTGGGAAAAAAA	0.333000													25	31					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119942901	119942901	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:119942901C>T	ENST00000327554.2	+	7	1141	c.676C>T	c.(676-678)Cga>Tga	p.R226*	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	226										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		TCCCACAATGCGAGTCACCAA	0.517000													17	35					0	0	1	0	0
DENND5A	23258	broad.mit.edu	37	11	9173944	9173944	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:9173944G>A	ENST00000328194.3	-	13	2802	c.2482C>T	c.(2482-2484)Cgg>Tgg	p.R828W	DENND5A_ENST00000527700.1_Missense_Mutation_p.R171W|DENND5A_ENST00000530044.1_Missense_Mutation_p.R828W	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	828	RUN 1.									breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TTTCTCTGCCGGTTGTCCTGA	0.498000													40	59					0	0	1	0	0
TMEM86A	144110	broad.mit.edu	37	11	18722575	18722575	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18722575C>T	ENST00000280734.2	+	2	213	c.117C>T	c.(115-117)agC>agT	p.S39S	TMEM86A_ENST00000527002.1_3'UTR	NM_153347.1	NP_699178.1	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	39						integral to membrane				endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|skin(2)	11						CGTGGGTCAGCACCCTCATCA	0.592000													62	80					0	0	1	0	0
CA4	762	broad.mit.edu	37	17	58235717	58235717	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:58235717C>A	ENST00000300900.4	+	7	753	c.654C>A	c.(652-654)ttC>ttA	p.F218L		NM_000717.3	NP_000708.1	P22748	CAH4_HUMAN	carbonic anhydrase IV	218					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(5)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	GGCACTACTTCCGCTACCTGG	0.577000													15	14					1.3612e-06	1.41782e-06	1	1	0
MBTPS1	8720	broad.mit.edu	37	16	84129223	84129223	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:84129223C>T	ENST00000343411.3	-	4	1104	c.609G>A	c.(607-609)tgG>tgA	p.W203*		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	203					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						ATCCCATCTGCCAGAGCACAT	0.567000													15	29					0	0	1	0	0
ASNSD1	54529	broad.mit.edu	37	2	190532519	190532519	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190532519G>A	ENST00000260952.4	+	5	1907	c.1494G>A	c.(1492-1494)gaG>gaA	p.E498E	ASNSD1_ENST00000607062.1_Silent_p.E17E	NM_019048.2	NP_061921.1	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	498	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(3)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			GTGCAGATGAGCAACTTGCAG	0.388000													20	34					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67314108	67314108	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67314108G>A	ENST00000360461.5	+	1	2696	c.161G>A	c.(160-162)gGg>gAg	p.G54E	PLEKHG4_ENST00000450733.1_Missense_Mutation_p.G54E|PLEKHG4_ENST00000379344.3_Missense_Mutation_p.G54E|PLEKHG4_ENST00000427155.2_Missense_Mutation_p.G54E	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	54					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CCACCAGCCGGGGCCACCCAG	0.597000													15	15					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11221443	11221443	+	Silent	SNP	C	C	T	rs13306515	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11221443C>T	ENST00000558518.1	+	7	1243	c.1056C>T	c.(1054-1056)tgC>tgT	p.C352C	LDLR_ENST00000545707.1_Silent_p.C225C|LDLR_ENST00000535915.1_Silent_p.C311C|LDLR_ENST00000455727.2_Silent_p.C184C|LDLR_ENST00000558013.1_Silent_p.C352C|LDLR_ENST00000557933.1_Silent_p.C352C	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	352	EGF-like 1.		C -> Y (in Mexico-2).		cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	AGCGAAGATGCGAAGGTGATT	0.597000													11	31					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124457684	124457684	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:124457684G>A	ENST00000329446.4	-	3	604	c.573C>T	c.(571-573)cgC>cgT	p.R191R		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	191										endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				GAAATGAGGAGCGTGTAAACC	0.488000													17	53					0	0	1	0	0
GLDN	342035	broad.mit.edu	37	15	51696718	51696718	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:51696718G>A	ENST00000335449.6	+	10	1479	c.1423G>A	c.(1423-1425)Gcc>Acc	p.A475T	GLDN_ENST00000396399.2_Missense_Mutation_p.A351T	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	475	Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane		p.A475T(1)		central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		GGCTGGCAACGCCTTCATTGC	0.473000													35	61					0	0	1	0	0
LAMP3	27074	broad.mit.edu	37	3	182870252	182870252	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:182870252C>T	ENST00000265598.3	-	3	1054	c.799G>A	c.(799-801)Gca>Aca	p.A267T	LAMP3_ENST00000466939.1_Missense_Mutation_p.A243T	NM_014398.3	NP_055213.2	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	267					cell proliferation	integral to membrane|lysosomal membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(2)	28	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			GCTTGCGTTGCGTTGGGGTCG	0.453000													66	97					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65489526	65489526	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:65489526C>T	ENST00000261883.4	-	9	3264	c.3098G>A	c.(3097-3099)tGc>tAc	p.C1033Y		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	1033					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						GGCTCGACGGCAGCTGCCCTG	0.577000													17	28					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45515271	45515271	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45515271C>T	ENST00000221452.8	+	4	391	c.241C>T	c.(241-243)Cgc>Tgc	p.R81C	RELB_ENST00000540120.1_Missense_Mutation_p.R81C|RELB_ENST00000505236.1_Missense_Mutation_p.R78C	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	81						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		GGGGCTGCCACGCCTGGTGTC	0.711000													4	9					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	197990131	197990131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:197990131C>T	ENST00000328737.2	-	6	525	c.449G>A	c.(448-450)cGt>cAt	p.R150H	ANKRD44_ENST00000337207.5_Missense_Mutation_p.R150H|ANKRD44_ENST00000409919.1_Missense_Mutation_p.R175H|ANKRD44_ENST00000282272.8_Missense_Mutation_p.R167H|ANKRD44_ENST00000409153.1_Missense_Mutation_p.R175H|ANKRD44_ENST00000450567.1_Missense_Mutation_p.R150H|ANKRD44_ENST00000539527.1_Missense_Mutation_p.R103H			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	175							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTGCAGAGCACGCCGGTCCTT	0.423000													29	34					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28483299	28483299	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28483299C>T	ENST00000261609.7	-	25	3921	c.3813G>A	c.(3811-3813)cgG>cgA	p.R1271R		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1271	Cytochrome b5 heme-binding.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCATGGATTCCCGGGTGTCTT	0.493000													29	50					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158725070	158725070	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158725070C>T	ENST00000368144.2	+	1	561	c.465C>T	c.(463-465)tgC>tgT	p.C155C		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					TAGCTATCTGCAATCCACTCC	0.483000													22	41					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925427	27925427	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:27925427C>T	ENST00000244623.1	+	1	409	c.409C>T	c.(409-411)Cac>Tac	p.H137Y		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						AGTTATCATGCACCAGAGACT	0.498000													38	79					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	91009601	91009601	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:91009601C>T	ENST00000268182.5	+	17	2092	c.1968C>T	c.(1966-1968)gtC>gtT	p.V656V	IQGAP1_ENST00000560738.1_Silent_p.V84V	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	656					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TGTATGGAGTCATCCCTGAGT	0.458000													29	27					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62417078	62417078	+	Silent	SNP	C	C	T	rs143580769		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62417078C>T	ENST00000330574.2	-	2	526	c.474G>A	c.(472-474)acG>acA	p.T158T		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	158					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						GGCCTGAGTACGTGCTGCTCA	0.562000													19	23					0	0	1	0	0
OBP2B	29989	broad.mit.edu	37	9	136081320	136081320	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136081320G>A	ENST00000372034.3	-	6	539	c.498C>T	c.(496-498)tgC>tgT	p.C166C	OBP2B_ENST00000461961.1_5'UTR|OBP2B_ENST00000372032.2_3'UTR	NM_014581.2	NP_055396.1	Q9NPH6	OBP2B_HUMAN	odorant binding protein 2B	166					chemosensory behavior|sensory perception of smell	extracellular region	odorant binding|transporter activity			central_nervous_system(2)|large_intestine(1)|lung(3)|skin(1)	7				OV - Ovarian serous cystadenocarcinoma(145;3.41e-06)|Epithelial(140;1.88e-05)		GTTCGGGAACGCAGCTTCCTG	0.622000													5	103					0	0	1	0	0
TTC23	64927	broad.mit.edu	37	15	99715278	99715278	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:99715278G>A	ENST00000394132.2	-	10	1659	c.842C>T	c.(841-843)gCt>gTt	p.A281V	TTC23_ENST00000394130.1_Missense_Mutation_p.A281V|TTC23_ENST00000558663.1_Missense_Mutation_p.A281V|TTC23_ENST00000394129.2_Missense_Mutation_p.A281V|TTC23_ENST00000394136.1_Missense_Mutation_p.A281V|TTC23_ENST00000394135.3_Missense_Mutation_p.A281V|TTC23_ENST00000262074.4_Missense_Mutation_p.A281V|TTC23_ENST00000558613.1_Missense_Mutation_p.A281V			Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	281							binding			endometrium(2)|large_intestine(3)|lung(9)|urinary_tract(2)	16	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			TCTCCCTGAAGCGACAGCAGC	0.517000													11	18					0	0	1	0	0
GAB2	9846	broad.mit.edu	37	11	77961318	77961318	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:77961318G>A	ENST00000361507.4	-	3	590	c.505C>T	c.(505-507)Ctg>Ttg	p.L169L	GAB2_ENST00000526030.1_Intron|GAB2_ENST00000340149.2_Silent_p.L131L	NM_080491.2	NP_536739.1	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2	169					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity		INTS4/GAB2(2)	NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			AACGTGAACAGAGTTGGCTGG	0.582000													32	62					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1670057	1670057	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:1670057C>A	ENST00000252804.4	-	10	1270	c.1220G>T	c.(1219-1221)aGc>aTc	p.S407I	PXDN_ENST00000483018.1_5'UTR	NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	407	Ig-like C2-type 2.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ATACTCTCCGCTGTCCCCCTG	0.587000													8	32					1.26484e-09	1.34508e-09	1	1	0
MBOAT1	154141	broad.mit.edu	37	6	20124743	20124743	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:20124743A>G	ENST00000541730.1	-	7	951	c.356T>C	c.(355-357)gTg>gCg	p.V119A	MBOAT1_ENST00000324607.7_Missense_Mutation_p.V268A			Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain containing 1	268					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(5)	20	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			CCAGTCATCCACAAGGCAGGT	0.468000													29	66					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50241791	50241791	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:50241791C>A	ENST00000338821.5	-	18	2220	c.1956G>T	c.(1954-1956)gaG>gaT	p.E652D	ATP9A_ENST00000402822.1_Missense_Mutation_p.E531D|ATP9A_ENST00000311637.5_Missense_Mutation_p.E516D	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	652					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GCAGCTGGTCCTCCACGCCCG	0.647000													11	10					4.3838e-07	4.58243e-07	1	1	0
SLIT2	9353	broad.mit.edu	37	4	20597356	20597356	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:20597356C>T	ENST00000504154.1	+	31	3471	c.3219C>T	c.(3217-3219)tgC>tgT	p.C1073C	SLIT2_ENST00000503837.1_Silent_p.C1069C|SLIT2_ENST00000503823.1_Silent_p.C1065C|SLIT2_ENST00000273739.5_Silent_p.C1086C	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1073	EGF-like 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GTGAACACTGCGACATCGATT	0.463000													6	96					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220164504	220164504	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:220164504G>T	ENST00000295718.2	-	10	1681	c.1441C>A	c.(1441-1443)Ctg>Atg	p.L481M	PTPRN_ENST00000423636.2_Missense_Mutation_p.L391M|AC114803.3_ENST00000417355.1_RNA|PTPRN_ENST00000409251.3_Intron	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	481					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GCCAGGCTCAGGGGCCTGGAG	0.577000													20	27					2.94398e-08	3.10271e-08	1	1	0
TIMM44	10469	broad.mit.edu	37	19	7992563	7992563	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7992563G>A	ENST00000270538.3	-	12	1486	c.1218C>T	c.(1216-1218)ggC>ggT	p.G406G	TIMM44_ENST00000598968.1_5'UTR	NM_006351.3	NP_006342.2	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44 homolog (yeast)	406					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	17						CCACCACCTCGCCTTTGGGGT	0.637000													28	33					0	0	1	0	0
OR13D1	286365	broad.mit.edu	37	9	107457453	107457453	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:107457453G>A	ENST00000318763.5	+	1	794	c.751G>A	c.(751-753)Gtg>Atg	p.V251M		NM_001004484.1	NP_001004484.1	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D, member 1	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(10)|ovary(1)|prostate(2)|skin(2)	19						CATCTCCTATGTGTTTATTCT	0.368000													40	46					0	0	1	0	0
SUV420H1	51111	broad.mit.edu	37	11	67941332	67941332	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67941332A>C	ENST00000304363.4	-	6	945	c.592T>G	c.(592-594)Ttg>Gtg	p.L198V	SUV420H1_ENST00000402185.2_Missense_Mutation_p.L175V|SUV420H1_ENST00000405515.1_Missense_Mutation_p.L198V|SUV420H1_ENST00000402789.1_Missense_Mutation_p.L198V|SUV420H1_ENST00000401547.2_Missense_Mutation_p.L198V	NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	198	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						TTACATGGCAATATTTCAAAT	0.294000													6	114					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98658505	98658505	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:98658505A>G	ENST00000261574.5	+	17	1853	c.1673A>G	c.(1672-1674)cAc>cGc	p.H558R	IPO5_ENST00000539640.1_Missense_Mutation_p.H415R|IPO5_ENST00000490680.1_Missense_Mutation_p.H540R|IPO5_ENST00000493492.2_3'UTR	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	540					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						TCACTGAAGCACATCGTTGAG	0.393000													4	88					0	0	1	0	0
USP19	10869	broad.mit.edu	37	3	49153358	49153358	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49153358C>A	ENST00000453664.1	-	11	1773	c.1455G>T	c.(1453-1455)aaG>aaT	p.K485N	USP19_ENST00000434032.2_Missense_Mutation_p.K495N|USP19_ENST00000417901.1_Missense_Mutation_p.K497N|USP19_ENST00000398892.3_Missense_Mutation_p.K434N|USP19_ENST00000398888.2_Missense_Mutation_p.K394N|USP19_ENST00000398896.1_Missense_Mutation_p.K202N|USP19_ENST00000398898.2_Missense_Mutation_p.K434N	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	394					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCACGGCAACCTTTGCACCAC	0.617000													17	30					2.94398e-08	3.10271e-08	1	1	0
ZCCHC11	23318	broad.mit.edu	37	1	52940596	52940596	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:52940596T>C	ENST00000371544.3	-	13	2897	c.2635A>G	c.(2635-2637)Aca>Gca	p.T879A	ZCCHC11_ENST00000257177.4_Missense_Mutation_p.T879A|ZCCHC11_ENST00000371541.1_5'UTR	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	879					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						GCATCTTCTGTAGCTTTGCAG	0.403000													26	62					0	0	1	0	0
NEURL	0	broad.mit.edu	37	10	105331341	105331341	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:105331341G>A	ENST00000369780.4	+	3	820	c.411G>A	c.(409-411)tcG>tcA	p.S137S	NEURL_ENST00000369777.2_Silent_p.S120S	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		137	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		ACCCTGACTCGCTGCCCAAGT	0.647000													8	9					0	0	1	0	0
ADRA2B	151	broad.mit.edu	37	2	96781468	96781468	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:96781468C>T	ENST00000409345.3	-	1	516	c.421G>A	c.(421-423)Gcc>Acc	p.A141T		NM_000682.5	NP_000673.2	P18089	ADA2B_HUMAN	adrenoceptor alpha 2B	141					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(3)	16					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	GAGATGACGGCGGCGATGAGC	0.682000													8	14					0	0	1	0	0
F2	2147	broad.mit.edu	37	11	46744817	46744817	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46744817G>A	ENST00000311907.5	+	5	460	c.404G>A	c.(403-405)cGc>cAc	p.R135H	F2_ENST00000530231.1_Missense_Mutation_p.R135H	NM_000506.3	NP_000497.1	P00734	THRB_HUMAN	coagulation factor II (thrombin)	135	Kringle 1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity	p.R135H(1)		endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	27		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	TGGAGGAGTCGCTACCCACAT	0.602000													40	40					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25468929	25468929	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:25468929C>T	ENST00000264709.3	-	12	1771	c.1434G>A	c.(1432-1434)cgG>cgA	p.R478R	DNMT3A_ENST00000321117.5_Silent_p.R478R|DNMT3A_ENST00000402667.1_Silent_p.R255R|DNMT3A_ENST00000380746.4_Silent_p.R289R	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	478					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTACACCAGCCGCTCTGCAA	0.627000			"""Mis, F, N, S"""		AML								7	41					0	0	1	0	0
MPC1	51660	broad.mit.edu	37	6	166780295	166780295	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:166780295G>A	ENST00000360961.6	-	3	281	c.160C>T	c.(160-162)Cgg>Tgg	p.R54W	MPC1_ENST00000487218.1_5'UTR|MPC1_ENST00000341756.6_Missense_Mutation_p.R54W	NM_016098.2	NP_057182.1			mitochondrial pyruvate carrier 1																		AATGTCATCCGCCCACTGATA	0.433000													33	60					0	0	1	0	0
ZYX	7791	broad.mit.edu	37	7	143085619	143085619	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:143085619G>A	ENST00000322764.5	+	7	1527	c.1182G>A	c.(1180-1182)gcG>gcA	p.A394A	ZYX_ENST00000392910.2_Silent_p.A237A|ZYX_ENST00000449423.2_Silent_p.A307A	NM_001010972.1|NM_003461.4	NP_001010972.1|NP_003452.1	Q15942	ZYX_HUMAN	zyxin	394	LIM zinc-binding 1.				cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)	17	Melanoma(164;0.205)					TGGCCCGGGCGCAGCCAGCCG	0.617000													21	20					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25606390	25606390	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:25606390C>T	ENST00000329474.6	+	35	4104	c.3736C>T	c.(3736-3738)Cgg>Tgg	p.R1246W		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1246	Poly-Ser.				actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						CTCCAGGTCTCGGAGCTCATC	0.587000													8	15					0	0	1	0	0
PPP2R1B	5519	broad.mit.edu	37	11	111625257	111625257	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:111625257G>A	ENST00000527614.1	-	8	1060	c.995C>T	c.(994-996)aCc>aTc	p.T332I	PPP2R1B_ENST00000427203.2_Missense_Mutation_p.T171I|PPP2R1B_ENST00000311129.5_Missense_Mutation_p.T332I|PPP2R1B_ENST00000426998.2_Missense_Mutation_p.T268I|PPP2R1B_ENST00000393055.2_Missense_Mutation_p.T205I|PPP2R1B_ENST00000341980.6_Missense_Mutation_p.T332I	NM_001177562.1|NM_002716.4	NP_001171033.1|NP_002707.3	P30154	2AAB_HUMAN	protein phosphatase 2, regulatory subunit A, beta	332							protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|liver(1)|lung(10)|prostate(1)|urinary_tract(2)	22		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		CATAATTATGGTCTCTCTATC	0.313000													11	24					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12904067	12904067	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:12904067C>T	ENST00000380659.3	+	3	579	c.440C>T	c.(439-441)cCg>cTg	p.P147L		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	147					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	CAGGGCCTCCCGCCTAGCTTA	0.458000													41	8					0	0	1	0	0
ZNF616	90317	broad.mit.edu	37	19	52619034	52619034	+	Silent	SNP	G	G	A	rs139023956		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:52619034G>A	ENST00000600228.1	-	4	1644	c.1383C>T	c.(1381-1383)ggC>ggT	p.G461G	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		AAGCTTTCTCGCCGGTATGAA	0.383000													52	97					0	0	1	0	0
KLRAP1	0	broad.mit.edu	37	12	10746521	10746521	+	RNA	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:10746521T>C	ENST00000510134.2	-	0	398																				breast(1)|large_intestine(1)|lung(1)	3						CAAGTCTGTTTACATCCCTTC	0.368000													21	26					0	0	1	0	0
CCDC146	57639	broad.mit.edu	37	7	76888316	76888316	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:76888316A>G	ENST00000285871.4	+	7	816	c.689A>G	c.(688-690)gAa>gGa	p.E230G	CCDC146_ENST00000431197.1_5'UTR	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	230										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				TACTAGGATGAAGTGGCCCAC	0.318000													3	46					0	0	1	0	0
RAB3A	5864	broad.mit.edu	37	19	18313528	18313528	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18313528C>T	ENST00000222256.4	-	2	201	c.23G>A	c.(22-24)cGc>cAc	p.R8H	RAB3A_ENST00000464076.2_Intron	NM_002866.4	NP_002857.1	P20336	RAB3A_HUMAN	RAB3A, member RAS oncogene family	8					glutamate secretion|protein transport|small GTPase mediated signal transduction	clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|plasma membrane|synaptic vesicle	GTP binding|GTPase activity			NS(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	8						CTGCCCATAGCGCGAGTCTGT	0.587000											OREG0025360	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	90					0	0	1	0	0
TLK2	11011	broad.mit.edu	37	17	60685410	60685410	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:60685410C>T	ENST00000582809.1	+	22	2236	c.1533C>T	c.(1531-1533)ggC>ggT	p.G511G	TLK2_ENST00000326270.9_Silent_p.G682G|TLK2_ENST00000542523.1_Silent_p.G628G|TLK2_ENST00000346027.5_Silent_p.G660G|TLK2_ENST00000343388.7_Silent_p.G628G			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	682	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						AGCCTTTTGGCCATAACCAGT	0.403000													15	27					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43479517	43479517	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:43479517C>T	ENST00000282041.5	-	27	4695	c.4661G>A	c.(4660-4662)cGg>cAg	p.R1554Q	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	1554					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						CTGAGATTCCCGAAGAGCTGC	0.453000													11	21					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155629458	155629458	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155629458C>T	ENST00000368340.5	-	10	2705	c.2597G>A	c.(2596-2598)gGa>gAa	p.G866E	YY1AP1_ENST00000368339.5_Missense_Mutation_p.G886E|YY1AP1_ENST00000368330.2_Missense_Mutation_p.G748E|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000311573.5_Missense_Mutation_p.G717E|YY1AP1_ENST00000361831.5_Missense_Mutation_p.G737E|YY1AP1_ENST00000404643.1_Missense_Mutation_p.G728E|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000407221.1_Missense_Mutation_p.G717E|YY1AP1_ENST00000295566.4_Missense_Mutation_p.G794E|YY1AP1_ENST00000535662.1_Missense_Mutation_p.G594E|YY1AP1_ENST00000347088.5_Missense_Mutation_p.G748E|YY1AP1_ENST00000355499.4_Missense_Mutation_p.G748E|YY1AP1_ENST00000359205.5_Missense_Mutation_p.G737E	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TCAAAGAAATCCACTGATTTC	0.493000													5	91					0	0	1	0	0
MAP3K12	7786	broad.mit.edu	37	12	53876414	53876414	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53876414G>A	ENST00000267079.2	-	12	2299	c.2074C>T	c.(2074-2076)Cgg>Tgg	p.R692W	MAP3K12_ENST00000547488.1_Missense_Mutation_p.R725W|MAP3K12_ENST00000547035.1_Missense_Mutation_p.R725W	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	692					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding	p.R692R(1)|p.R725R(1)		NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						GACCCAGCCCGGCTTCCTCCC	0.627000													40	51					0	0	1	0	0
SCUBE2	57758	broad.mit.edu	37	11	9049017	9049017	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:9049017C>T	ENST00000457346.2	-	20	2669	c.2595G>A	c.(2593-2595)acG>acA	p.T865T	SCUBE2_ENST00000450649.2_Intron|RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000309263.3_Silent_p.T836T|SCUBE2_ENST00000520467.1_Silent_p.T808T			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	836	CUB.					extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		TGATGGTCCACGTACACTCGG	0.552000													14	21					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62960181	62960181	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:62960181C>T	ENST00000393630.3	+	30	4668	c.4277C>T	c.(4276-4278)gCg>gTg	p.A1426V	MON2_ENST00000280379.6_Missense_Mutation_p.A1426V|MON2_ENST00000552738.1_Missense_Mutation_p.A1396V|MON2_ENST00000393632.2_Missense_Mutation_p.A1425V|MON2_ENST00000546600.1_Missense_Mutation_p.A1425V|MON2_ENST00000393629.2_Missense_Mutation_p.A1419V	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	1426					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CAAAAAACAGCGTGTCACAAA	0.353000													19	57					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467314	74467314	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:74467314C>T	ENST00000249842.3	+	2	472	c.115C>T	c.(115-117)Cgc>Tgc	p.R39C	RP11-665J16.1_ENST00000561647.1_RNA|ISLR_ENST00000395118.1_Missense_Mutation_p.R39C	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	39	LRRNT.				cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						CTGTGCCTACCGCGACCTAGA	0.647000													19	29					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3648065	3648065	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:3648065A>G	ENST00000378295.4	+	13	1678	c.1523A>G	c.(1522-1524)tAt>tGt	p.Y508C	TP73_ENST00000603362.1_Intron|TP73_ENST00000378290.4_Missense_Mutation_p.Y437C|TP73_ENST00000378288.4_Missense_Mutation_p.Y459C|TP73_ENST00000357733.3_Intron|TP73_ENST00000354437.4_Intron|TP73_ENST00000346387.4_Missense_Mutation_p.Y412C|TP73_ENST00000604479.1_Missense_Mutation_p.Y412C|TP73_ENST00000378280.1_Silent_p.V409V|TP73_ENST00000378285.1_Intron|TP73_ENST00000604074.1_Intron	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	508	SAM.				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		TGCATCGAGTATTTCACCTCC	0.542000													62	78					0	0	1	0	0
SGK223	0	broad.mit.edu	37	8	8175954	8175954	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:8175954G>A	ENST00000520004.1	-	6	4195	c.3931C>T	c.(3931-3933)Cgt>Tgt	p.R1311C	SGK223_ENST00000330777.4_Missense_Mutation_p.R1311C			Q86YV5	SG223_HUMAN		1311	Protein kinase.		R -> H.				ATP binding|non-membrane spanning protein tyrosine kinase activity										ATGCGGATACGCTTGATGGGG	0.711000													21	20					0	0	1	0	0
INCENP	3619	broad.mit.edu	37	11	61912668	61912668	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61912668G>A	ENST00000394818.3	+	13	1945	c.1743G>A	c.(1741-1743)gtG>gtA	p.V581V	INCENP_ENST00000278849.4_Silent_p.V577V	NM_001040694.1	NP_001035784.1	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	581					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TCCGCAAGGTGCTGCAGGCCC	0.607000													25	35					0	0	1	0	0
EHBP1	23301	broad.mit.edu	37	2	63175805	63175805	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:63175805C>A	ENST00000263991.5	+	14	2411	c.1929C>A	c.(1927-1929)taC>taA	p.Y643*	EHBP1_ENST00000405015.3_Nonsense_Mutation_p.Y608*|EHBP1_ENST00000354487.3_Nonsense_Mutation_p.Y608*|EHBP1_ENST00000431489.1_Nonsense_Mutation_p.Y608*|EHBP1_ENST00000405289.1_Nonsense_Mutation_p.Y608*	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	643						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			CCTCCCCTTACTGTCGCAGGA	0.468000													14	19					1.49906e-05	1.54943e-05	1	1	0
DHX34	9704	broad.mit.edu	37	19	47884452	47884452	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47884452G>A	ENST00000328771.4	+	16	3518	c.3169G>A	c.(3169-3171)Gac>Aac	p.D1057N		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	1057						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GAATGACACAGACCTGTACAG	0.672000													19	37					0	0	1	0	0
PCNXL4	64430	broad.mit.edu	37	14	60600823	60600823	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:60600823C>T	ENST00000406854.1	+	11	3957	c.3403C>T	c.(3403-3405)Cgt>Tgt	p.R1135C	PCNXL4_ENST00000535349.1_3'UTR|PCNXL4_ENST00000406949.1_Intron|PCNXL4_ENST00000404681.2_Missense_Mutation_p.R1135C|PCNXL4_ENST00000317623.4_Missense_Mutation_p.R901C					pecanex-like 4 (Drosophila)																		TGATGAAGAACGTTATAGTAT	0.398000													23	40					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92577883	92577883	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:92577883C>T	ENST00000298047.6	+	18	11367	c.11350C>T	c.(11350-11352)Cgt>Tgt	p.R3784C	FAT3_ENST00000409404.2_Missense_Mutation_p.R3784C|FAT3_ENST00000533797.1_Missense_Mutation_p.R119C|FAT3_ENST00000525166.1_Missense_Mutation_p.R3634C			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3784					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGGAACGTGCGTTGCACCTG	0.507000										TCGA Ovarian(4;0.039)			3	3					0	0	1	0	0
PROCR	10544	broad.mit.edu	37	20	33764034	33764034	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:33764034T>C	ENST00000216968.4	+	3	468	c.386T>C	c.(385-387)gTc>gCc	p.V129A	EDEM2_ENST00000540582.1_Intron	NM_006404.3	NP_006395.2	Q9UNN8	EPCR_HUMAN	protein C receptor, endothelial	129					antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity			breast(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	AGAGCCCATGTCTTCTTCGAA	0.602000													26	38					0	0	1	0	0
MRPL41	64975	broad.mit.edu	37	9	140446702	140446702	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140446702G>A	ENST00000371443.5	+	2	957	c.169G>A	c.(169-171)Gtc>Atc	p.V57I		NM_032477.2	NP_115866.1	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	57					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			breast(1)|lung(1)	2	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		CAAGGAGATGGTCCCGGAGTT	0.687000													12	21					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28986322	28986322	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:28986322T>A	ENST00000359747.4	+	12	1948	c.1919T>A	c.(1918-1920)aTc>aAc	p.I640N	RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.I640N	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	640					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GTTCTGGGCATCCTGCTACTG	0.458000													35	56					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65623855	65623855	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:65623855G>A	ENST00000327987.4	-	8	1542	c.1291C>T	c.(1291-1293)Cgg>Tgg	p.R431W	IGDCC3_ENST00000559231.1_5'UTR	NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	431	Fibronectin type-III 1.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GAGACTGCCCGCACATTGCGG	0.627000													5	23					0	0	1	0	0
ACKR2	1238	broad.mit.edu	37	3	42906816	42906816	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:42906816G>A	ENST00000422265.1	+	3	997	c.822G>A	c.(820-822)acG>acA	p.T274T	KRBOX1_ENST00000426937.1_Intron|ACKR2_ENST00000442925.1_Silent_p.T274T|CYP8B1_ENST00000437102.1_Intron|ACKR2_ENST00000273145.2_Silent_p.T274T|ACKR2_ENST00000471537.1_Intron	NM_001296.4	NP_001287.2			atypical chemokine receptor 2																		TTCTGCATACGCTGTTGGACC	0.537000													50	64					0	0	1	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28275623	28275623	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:28275623T>C	ENST00000373894.3	+	3	514	c.323T>C	c.(322-324)gTa>gCa	p.V108A	SMPDL3B_ENST00000373888.4_Missense_Mutation_p.V108A|SMPDL3B_ENST00000549094.1_Missense_Mutation_p.V108A|RP11-460I13.2_ENST00000448015.1_RNA	NM_014474.2	NP_055289.2	Q92485	ASM3B_HUMAN	sphingomyelin phosphodiesterase, acid-like 3B	108					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	16		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		GAGGCAGCTGTACTGGAAATT	0.527000													8	22					0	0	1	0	0
WFS1	7466	broad.mit.edu	37	4	6304076	6304076	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:6304076G>A	ENST00000226760.1	+	8	2724	c.2554G>A	c.(2554-2556)Gcc>Acc	p.A852T	WFS1_ENST00000503569.1_Missense_Mutation_p.A852T	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	852					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		CAACTGCATGGCCCAGCTCTC	0.627000													12	16					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130332480	130332480	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:130332480G>A	ENST00000299164.2	+	4	1347	c.1347G>A	c.(1345-1347)gaG>gaA	p.E449E		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	449	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		AGCAGTGCGAGCTGGCTTTTG	0.642000													19	44					0	0	1	0	0
KRT35	3886	broad.mit.edu	37	17	39635746	39635746	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39635746C>T	ENST00000246639.2	-	3	606	c.474G>A	c.(472-474)acG>acA	p.T158T	KRT35_ENST00000393989.1_Silent_p.T188T			Q92764	KRT35_HUMAN	keratin 35	188	Coil 1B.|Rod.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.000286)				GGGACACCTCCGTCTCATACC	0.587000													14	31					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33653961	33653961	+	Silent	SNP	C	C	T	rs149221361		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33653961C>T	ENST00000374316.5	+	43	6859	c.5799C>T	c.(5797-5799)aaC>aaT	p.N1933N	ITPR3_ENST00000605930.1_Silent_p.N1933N			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	1933					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						ATGAGGACAACGTGGGCCTCG	0.607000													4	15					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2930332	2930332	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:2930332C>T	ENST00000254695.8	+	22	2165	c.2075C>T	c.(2074-2076)gCc>gTc	p.A692V	RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.A677V|RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.A692V|RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.A673V	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	692	Ser-rich.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						GGGGCAGCTGCCACCCCGATC	0.647000													4	1					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74631983	74631983	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:74631983C>T	ENST00000358632.4	-	6	1323	c.628G>A	c.(628-630)Gcc>Acc	p.A210T	CYP11A1_ENST00000268053.6_Missense_Mutation_p.A368T|CYP11A1_ENST00000419019.2_Missense_Mutation_p.A210T	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	368					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	AGCATCGTGGCCATGTCTCCC	0.617000													7	10					0	0	1	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25363868	25363868	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:25363868G>A	ENST00000302874.4	+	10	1178	c.1154G>A	c.(1153-1155)cGg>cAg	p.R385Q		NM_024936.2	NP_079212.2	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	385							methyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)	9		Breast(46;0.0503)				CCGTGTCAACGGTATGTTTCT	0.333000													12	25					0	0	1	0	0
SERPINE1	5054	broad.mit.edu	37	7	100779042	100779042	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100779042C>T	ENST00000223095.4	+	7	1204	c.1047C>T	c.(1045-1047)atC>atT	p.I349I	SERPINE1_ENST00000445463.2_Silent_p.I334I	NM_000602.4	NP_000593.1	P05121	PAI1_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	349					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)	20	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	AAGTGAAGATCGAGGTGAACG	0.577000													10	25					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57760785	57760785	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57760785C>T	ENST00000360716.3	+	15	2237	c.2016C>T	c.(2014-2016)taC>taT	p.Y672Y	CCDC135_ENST00000336825.8_Silent_p.Y607Y|CCDC135_ENST00000394337.4_Silent_p.Y672Y			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	672						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						TCTACCAGTACGAGGCCATGA	0.577000													7	14					0	0	1	0	0
NEIL1	79661	broad.mit.edu	37	15	75646188	75646188	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75646188G>A	ENST00000564784.1	+	7	1456	c.827G>A	c.(826-828)gGc>gAc	p.G276D	NEIL1_ENST00000569035.1_Missense_Mutation_p.G276D|NEIL1_ENST00000355059.4_Missense_Mutation_p.G276D			Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1 (E. coli)	276					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)	13						GACCGGCATGGCCGTACCATC	0.622000								Base excision repair (BER), DNA glycosylases					40	75					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111074	7111074	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7111074C>T	ENST00000306904.5	+	1	910	c.723C>T	c.(721-723)cgC>cgT	p.R241R		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	241	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACACCCACCGCGATTACGGCC	0.657000													9	18					0	0	1	0	0
EMID1	129080	broad.mit.edu	37	22	29611568	29611568	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:29611568G>A	ENST00000334018.6	+	3	456	c.268G>A	c.(268-270)Gcc>Acc	p.A90T	EMID1_ENST00000484039.1_3'UTR|EMID1_ENST00000404820.3_Missense_Mutation_p.A90T|EMID1_ENST00000404755.3_Missense_Mutation_p.A90T	NM_001267895.1|NM_133455.3	NP_001254824.1|NP_597712.2	Q96A84	EMID1_HUMAN	EMI domain containing 1	90	EMI.					collagen				NS(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(2)|skin(3)	12						GATAGTGACCGCCCGTGAGTG	0.627000													14	26					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71977912	71977912	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:71977912G>A	ENST00000266674.5	+	18	2433	c.2122G>A	c.(2122-2124)Gcc>Acc	p.A708T	LGR5_ENST00000540815.2_Missense_Mutation_p.A684T|LGR5_ENST00000536515.1_Missense_Mutation_p.A636T			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	708						integral to plasma membrane	protein-hormone receptor activity	p.A708T(1)	NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						CAAGTATGGCGCCTCCCCTCT	0.552000													61	70					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216062234	216062234	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:216062234G>A	ENST00000366943.2	-	41	8143	c.7757C>T	c.(7756-7758)aCa>aTa	p.T2586I	USH2A_ENST00000307340.3_Missense_Mutation_p.T2586I|RP5-1111A8.3_ENST00000414995.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2586	Fibronectin type-III 12.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATGCATCACTGTGCAATTAGT	0.423000										HNSCC(13;0.011)			40	49					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49159636	49159636	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49159636G>A	ENST00000418109.1	-	29	4905	c.4741C>T	c.(4741-4743)Cgt>Tgt	p.R1581C	LAMB2_ENST00000305544.4_Missense_Mutation_p.R1581C	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1581	Domain I.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCGGCACGACGCACATCTCCT	0.607000													12	21					0	0	1	0	0
SMTN	6525	broad.mit.edu	37	22	31489822	31489822	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31489822G>A	ENST00000404574.1	+	1	479	c.389G>A	c.(388-390)cGc>cAc	p.R130H	SMTN_ENST00000333137.7_Intron|SMTN_ENST00000347557.2_Intron|SMTN_ENST00000358743.1_Intron			P53814	SMTN_HUMAN	smoothelin	533					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						TTCAGCACCCGCCGCCGCTCC	0.687000													3	12					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	114948128	114948128	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:114948128G>A	ENST00000358465.2	-	15	2755	c.2672C>T	c.(2671-2673)gCt>gTt	p.A891V	TRIM33_ENST00000476908.1_5'UTR|TRIM33_ENST00000369543.2_Missense_Mutation_p.A891V|TRIM33_ENST00000450349.2_Missense_Mutation_p.A523V	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	891					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGGCAGACAGCACACCAGTC	0.453000			T	RET	papillary thyroid								60	73					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203186921	203186921	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:203186921A>T	ENST00000367229.1	-	10	1136	c.1102T>A	c.(1102-1104)Ttc>Atc	p.F368I	CHIT1_ENST00000255427.3_Missense_Mutation_p.F349I|CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000535569.1_Missense_Mutation_p.F359I	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	368					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						TTGCAGGAGAAGCCGGCAAAG	0.602000													9	12					0	0	1	0	0
SLC3A1	6519	broad.mit.edu	37	2	44541157	44541157	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:44541157C>T	ENST00000409229.3	+	9	1684	c.1684C>T	c.(1684-1686)Cac>Tac	p.H562Y	SLC3A1_ENST00000409294.1_Missense_Mutation_p.H182Y|SLC3A1_ENST00000409740.3_Intron|SLC3A1_ENST00000409387.1_Intron|SLC3A1_ENST00000409380.1_Intron|SLC3A1_ENST00000260649.6_Intron			Q07837	SLC31_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 1	0					carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(3)	26		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	TGAAAGTACACACTCACCCTG	0.343000													6	10					0	0	1	0	0
GNPDA1	10007	broad.mit.edu	37	5	141384537	141384537	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:141384537G>A	ENST00000508177.1	-	4	1312	c.554C>T	c.(553-555)gCc>gTc	p.A185V	GNPDA1_ENST00000513454.1_Missense_Mutation_p.A185V|GNPDA1_ENST00000503794.1_Missense_Mutation_p.A185V|GNPDA1_ENST00000500692.2_Missense_Mutation_p.A185V|GNPDA1_ENST00000542860.1_Missense_Mutation_p.A108V|GNPDA1_ENST00000311337.6_Missense_Mutation_p.A185V|GNPDA1_ENST00000458112.2_Missense_Mutation_p.A151V			P46926	GNPI1_HUMAN	glucosamine-6-phosphate deaminase 1	185					generation of precursor metabolites and energy|glucosamine catabolic process|N-acetylglucosamine metabolic process|single fertilization	cytoplasm	glucosamine-6-phosphate deaminase activity|hydrolase activity			central_nervous_system(1)|lung(1)|skin(3)|stomach(1)	6		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCGTCAAGGCCATGGTGGG	0.562000													8	2					0	0	1	0	0
C19orf66	55337	broad.mit.edu	37	19	10200616	10200616	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10200616C>T	ENST00000397881.3	+	5	601	c.124C>T	c.(124-126)Cgc>Tgc	p.R42C	C19orf66_ENST00000591813.1_Missense_Mutation_p.R93C|CTD-2240E14.4_ENST00000589622.1_RNA|C19orf66_ENST00000253110.11_Missense_Mutation_p.R93C			Q9NUL5	CS066_HUMAN	chromosome 19 open reading frame 66	93										large_intestine(3)|skin(1)	4						AGCCAACCTACGCATGTTTCA	0.647000													5	9					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43544999	43544999	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43544999G>A	ENST00000220420.5	-	6	827	c.820C>T	c.(820-822)Cgc>Tgc	p.R274C	TGM5_ENST00000349114.4_Missense_Mutation_p.R192C	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	274					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity	p.R274C(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	TGCCCGTAGCGCACGGGCTGG	0.582000													27	28					0	0	1	0	0
HSPA4L	22824	broad.mit.edu	37	4	128748471	128748471	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:128748471G>A	ENST00000296464.3	+	17	2469	c.2058G>A	c.(2056-2058)caG>caA	p.Q686Q	HSPA4L_ENST00000505726.1_Silent_p.Q660Q|HSPA4L_ENST00000439123.2_Silent_p.Q717Q|HSPA4L_ENST00000508776.1_Silent_p.Q686Q	NM_014278.2	NP_055093.2	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	686					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						AATACGGCCAGCCTATTCAAA	0.318000													21	39					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152327725	152327725	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:152327725C>T	ENST00000388718.5	-	3	2609	c.2537G>A	c.(2536-2538)gGc>gAc	p.G846D	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	846	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCATGTTGGCCATAGCTGGA	0.522000													126	180					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	628555	628555	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:628555C>T	ENST00000255622.6	+	2	601	c.558C>T	c.(556-558)gtC>gtT	p.V186V	PDE6B_ENST00000496514.1_Silent_p.V186V	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	186	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						GCAAAGACGTCGTGGCGGTGA	0.562000													18	29					0	0	1	0	0
PSMB11	122706	broad.mit.edu	37	14	23512147	23512147	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23512147G>A	ENST00000408907.2	+	1	772	c.713G>A	c.(712-714)cGc>cAc	p.R238H		NM_001099780.1	NP_001093250.1	A5LHX3	PSB11_HUMAN	proteasome (prosome, macropain) subunit, beta type, 11	238					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			endometrium(1)|kidney(2)|lung(4)	7	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)		CATGTGTCACGCAGTGATGCC	0.632000													20	16					0	0	1	0	0
MAD1L1	8379	broad.mit.edu	37	7	2020131	2020131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2020131C>T	ENST00000406869.1	-	15	2019	c.1462G>A	c.(1462-1464)Gaa>Aaa	p.E488K	MAD1L1_ENST00000265854.7_Missense_Mutation_p.E488K|MAD1L1_ENST00000402746.1_Missense_Mutation_p.E396K|MAD1L1_ENST00000399654.2_Missense_Mutation_p.E488K			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	488	Necessary for interaction with NEK2.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		AAGCTCTGTTCGGCAGAGCTG	0.612000													8	12					0	0	1	0	0
IGLV2-8	0	broad.mit.edu	37	22	23165570	23165570	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:23165570C>T	ENST00000390317.2	+	0	303																											CCAGCAGTGACGTTGGTGGTT	0.587000													7	240					0	0	1	0	0
SLC35D1	23169	broad.mit.edu	37	1	67507943	67507943	+	Silent	SNP	C	C	T	rs142750829		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:67507943C>T	ENST00000235345.5	-	8	790	c.705G>A	c.(703-705)gcG>gcA	p.A235A	SLC35D1_ENST00000506472.2_Silent_p.A156A	NM_015139.2	NP_055954.1	Q9NTN3	S35D1_HUMAN	solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1	235					chondroitin sulfate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(4)	10					Lorazepam(DB00186)	CTGTGAAATACGCAATGGCCA	0.388000													49	84					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152490260	152490260	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:152490260C>T	ENST00000427231.2	-	65	9524	c.9322G>A	c.(9322-9324)Gtg>Atg	p.V3108M	NEB_ENST00000172853.10_Intron|NEB_ENST00000409198.1_Intron|NEB_ENST00000604864.1_Missense_Mutation_p.V3108M|NEB_ENST00000603639.1_Missense_Mutation_p.V3108M|NEB_ENST00000397345.3_Missense_Mutation_p.V3108M	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3108					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTATAGTCCACGTCACTGACT	0.542000													60	93					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67768131	67768131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:67768131C>T	ENST00000335894.4	+	18	2840	c.2774C>T	c.(2773-2775)gCc>gTc	p.A925V	IQCH_ENST00000358767.3_Missense_Mutation_p.A661V|IQCH_ENST00000360277.4_Missense_Mutation_p.A586V|IQCH-AS1_ENST00000559298.1_lincRNA|IQCH_ENST00000546225.1_Missense_Mutation_p.A582V	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	925										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		ATCTGTAGGGCCCATGGCATT	0.498000													19	32					0	0	1	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15127455	15127455	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:15127455G>A	ENST00000253699.3	-	6	916	c.303C>T	c.(301-303)agC>agT	p.S101S	ZFYVE20_ENST00000476527.2_Silent_p.S101S|ZFYVE20_ENST00000435849.3_Silent_p.S101S|ZFYVE20_ENST00000449964.2_5'UTR	NM_022340.2	NP_071735.2	Q9H1K0	RBNS5_HUMAN	zinc finger, FYVE domain containing 20	101	Necessary for the correct targeting to endosomes.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|skin(3)|stomach(1)|urinary_tract(2)	26						CGGAAAGATGGCTTCTCACAG	0.418000													36	127					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49772313	49772313	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:49772313A>G	ENST00000492622.2	+	22	2991	c.2686A>G	c.(2686-2688)Agc>Ggc	p.S896G	FNDC3A_ENST00000541916.1_Missense_Mutation_p.S896G|FNDC3A_ENST00000398316.3_Missense_Mutation_p.S840G	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	896	Fibronectin type-III 7.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		CCTTGCCTACAGCATAGACTT	0.388000													44	51					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76905558	76905558	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:76905558G>A	ENST00000409709.3	+	32	4584	c.4312G>A	c.(4312-4314)Gcc>Acc	p.A1438T	MYO7A_ENST00000409619.2_Missense_Mutation_p.A1427T|MYO7A_ENST00000458637.2_Missense_Mutation_p.A1438T	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1438	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GGCCATCGCCGCCCACAAGAA	0.617000													5	9					0	0	1	0	0
BRD2	6046	broad.mit.edu	37	6	32946063	32946063	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32946063G>A	ENST00000395289.2	+	10	3340	c.1739G>A	c.(1738-1740)cGc>cAc	p.R580H	BRD2_ENST00000449085.2_Missense_Mutation_p.R533H|BRD2_ENST00000374825.4_Missense_Mutation_p.R580H|BRD2_ENST00000395287.1_Missense_Mutation_p.R580H|BRD2_ENST00000443797.2_Missense_Mutation_p.R460H|BRD2_ENST00000374831.4_Missense_Mutation_p.R580H			P25440	BRD2_HUMAN	bromodomain containing 2	580					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						AGGGCACCCCGCCCACCTCAA	0.552000													26	38					0	0	1	0	0
PIK3CD	5293	broad.mit.edu	37	1	9775775	9775775	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:9775775C>T	ENST00000536656.1	+	4	526	c.318C>T	c.(316-318)ggC>ggT	p.G106G	PIK3CD_ENST00000361110.2_Silent_p.G106G|PIK3CD_ENST00000377346.4_Silent_p.G106G			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	106					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		CCCGTGAGGGCGACCGCGTGA	0.662000													10	43					0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45459744	45459744	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:45459744G>A	ENST00000371438.1	+	5	1110	c.752G>A	c.(751-753)cGc>cAc	p.R251H	RUNX2_ENST00000359524.5_Missense_Mutation_p.R237H|RUNX2_ENST00000371432.3_Missense_Mutation_p.R237H|RUNX2_ENST00000576263.1_Missense_Mutation_p.R251H|RUNX2_ENST00000352853.5_Missense_Mutation_p.R319H|RUNX2_ENST00000465038.2_Missense_Mutation_p.R251H|RUNX2_ENST00000541979.1_Missense_Mutation_p.R319H|RUNX2_ENST00000371436.6_Missense_Mutation_p.R251H	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	251	Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						GATTTAGGGCGCATTCCTCAT	0.473000													52	100					0	0	1	0	0
ETV4	2118	broad.mit.edu	37	17	41610182	41610182	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41610182C>T	ENST00000319349.5	-	8	969	c.671G>A	c.(670-672)aGc>aAc	p.S224N	ETV4_ENST00000393664.2_Missense_Mutation_p.S224N|ETV4_ENST00000545954.1_Missense_Mutation_p.S185N|ETV4_ENST00000591713.1_Missense_Mutation_p.S224N|ETV4_ENST00000545089.1_Missense_Mutation_p.S170N|ETV4_ENST00000538265.1_Missense_Mutation_p.S185N	NM_001079675.2	NP_001073143.1	P43268	ETV4_HUMAN	ets variant 4	224	Gln-rich.				positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S224I(1)	EWSR1/ETV4(6)|CANT1/ETV4(3)|TMPRSS2/ETV4(13)|DDX5_ENST00000540698/ETV4(2)|KLK2/ETV4(2)	ovary(2)|upper_aerodigestive_tract(1)	3		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)		TTGCTTAAAGCTCTGCTGGGG	0.637000			T	"""EWSR1, TMPRSS2, DDX5, KLK2, CANT1"""	"""Ewing sarcoma, Prostate carcinoma"""								15	27					0	0	1	0	0
NTSR2	23620	broad.mit.edu	37	2	11798758	11798758	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:11798758G>A	ENST00000306928.5	-	4	1114	c.1080C>T	c.(1078-1080)gcC>gcT	p.A360A		NM_012344.3	NP_036476.1	O95665	NTR2_HUMAN	neurotensin receptor 2	360					sensory perception	integral to plasma membrane				breast(1)|large_intestine(7)|lung(7)|prostate(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	AGGAGGACACGGCGTTGTAGA	0.537000													3	36					0	0	1	0	0
ALOX12	239	broad.mit.edu	37	17	6902685	6902685	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:6902685C>T	ENST00000251535.6	+	6	760	c.707C>T	c.(706-708)gCc>gTc	p.A236V	AC027763.2_ENST00000574377.1_3'UTR|RP11-589P10.7_ENST00000572547.1_RNA|AC027763.2_ENST00000399541.2_Intron	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	236	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						CTCAATGGTGCCAACCCCATG	0.552000													5	37					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121746949	121746949	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:121746949C>T	ENST00000452319.1	+	14	3519	c.3459C>T	c.(3457-3459)acC>acT	p.T1153T	GLI2_ENST00000314490.11_Intron|GLI2_ENST00000361492.4_Silent_p.T1153T			P10070	GLI2_HUMAN	GLI family zinc finger 2	1153					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GCTCCGGCACCGTAGACGCCC	0.622000													13	17					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105503410	105503410	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:105503410C>T	ENST00000276654.5	-	7	2179	c.2071G>A	c.(2071-2073)Gca>Aca	p.A691T	LRP12_ENST00000424843.2_Missense_Mutation_p.A672T|LRP12_ENST00000518375.1_5'UTR	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	691					endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTGCACATGCTCCTACTGTC	0.517000													18	31					0	0	1	0	0
RAB24	53917	broad.mit.edu	37	5	176729462	176729462	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176729462G>A	ENST00000303270.6	-	4	884	c.282C>T	c.(280-282)gaC>gaT	p.D94D	RAB24_ENST00000303251.6_Silent_p.D123D|RAB24_ENST00000393611.2_Silent_p.D123D			Q969Q5	RAB24_HUMAN	RAB24, member RAS oncogene family	123					autophagy|protein transport|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|protein binding					all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTTCCAGCAGGTCACTCTTGG	0.577000													27	59					0	0	1	0	0
RIPK1	8737	broad.mit.edu	37	6	3085632	3085632	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:3085632G>A	ENST00000259808.4	+	6	1126	c.828G>A	c.(826-828)ccG>ccA	p.P276P	RIPK1_ENST00000541791.1_Silent_p.P230P|RIPK1_ENST00000380409.2_Silent_p.P276P|RIPK1_ENST00000479389.1_3'UTR			Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine kinase 1	276	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				AAGCTCGGCCGACATTTCCTG	0.468000													12	17					0	0	1	0	0
STAT6	6778	broad.mit.edu	37	12	57496631	57496631	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57496631T>C	ENST00000300134.3	-	12	1611	c.1286A>G	c.(1285-1287)gAc>gGc	p.D429G	STAT6_ENST00000537215.2_Missense_Mutation_p.D319G|STAT6_ENST00000454075.3_Missense_Mutation_p.D429G|STAT6_ENST00000556155.1_Missense_Mutation_p.D429G|STAT6_ENST00000543873.2_Missense_Mutation_p.D429G|STAT6_ENST00000538913.2_Missense_Mutation_p.D319G	NM_001178078.1|NM_003153.4	NP_001171549.1|NP_003144.3	P42226	STAT6_HUMAN	signal transducer and activator of transcription 6, interleukin-4 induced	429					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	28						GAAGGCATTGTCCCACAGGAT	0.572000													16	23					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190606144	190606144	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190606144G>A	ENST00000520309.1	+	20	3865	c.3777G>A	c.(3775-3777)cgG>cgA	p.R1259R	ANKAR_ENST00000438402.2_3'UTR|ANKAR_ENST00000431575.2_Silent_p.R1188R|ANKAR_ENST00000281412.6_3'UTR|ANKAR_ENST00000313581.4_Silent_p.R1259R	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1259						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			CAATCCAACGGCTCTGCTATC	0.343000													24	61					0	0	1	0	0
HSP90B1	7184	broad.mit.edu	37	12	104340404	104340404	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104340404C>T	ENST00000299767.5	+	15	2218	c.2036C>T	c.(2035-2037)gCg>gTg	p.A679V		NM_003299.1	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	679					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	AGTTACTATGCGAGTCAGAAG	0.348000													13	29					0	0	1	0	0
NMBR	4829	broad.mit.edu	37	6	142396969	142396969	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:142396969C>T	ENST00000258042.1	-	3	1129	c.989G>A	c.(988-990)aGc>aAc	p.S330N	NMBR_ENST00000480652.1_5'UTR	NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	330					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		CCTCCTGAAGCTTTCACTGAG	0.488000													22	44					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126751581	126751581	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:126751581G>A	ENST00000251772.4	+	30	5497	c.5428G>A	c.(5428-5430)Gcg>Acg	p.A1810T	PLXNA1_ENST00000505278.1_3'UTR|PLXNA1_ENST00000393409.2_Missense_Mutation_p.A1833T			Q9UIW2	PLXA1_HUMAN	plexin A1	1833					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		GGACATGAGTGCGTATCTGGC	0.577000													9	39					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7736702	7736702	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7736702T>C	ENST00000572933.1	+	86	14595	c.13135T>C	c.(13135-13137)Tac>Cac	p.Y4379H	DNAH2_ENST00000389173.2_Missense_Mutation_p.Y4379H			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	4379					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCCAGGCATGTACTCCTGCCC	0.632000													40	52					0	0	1	0	0
PRM1	5619	broad.mit.edu	37	16	11374865	11374865	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:11374865C>T	ENST00000312511.3	-	2	251	c.140G>A	c.(139-141)cGa>cAa	p.R47Q	RMI2_ENST00000572173.1_Intron	NM_002761.2	NP_002752.1	P04553	HSP1_HUMAN	protamine 1	47					chromosome condensation|multicellular organismal development	nucleoplasm|nucleosome	DNA binding	p.0?(1)		large_intestine(2)|skin(2)	4						TCTTCTACATCGCGGTCTGTA	0.547000													63	112					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48697959	48697959	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48697959G>A	ENST00000544264.1	-	1	2389	c.2109C>T	c.(2107-2109)agC>agT	p.S703S	CELSR3_ENST00000164024.4_Silent_p.S703S			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	703	Cadherin 4.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGCCAGTGGCGCTGTTTATCA	0.547000													4	29					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49161443	49161443	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49161443C>T	ENST00000418109.1	-	25	3679	c.3515G>A	c.(3514-3516)cGc>cAc	p.R1172H	LAMB2_ENST00000305544.4_Missense_Mutation_p.R1172H	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1172	Laminin EGF-like 13.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity	p.R1172L(1)		NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTGGTCACAGCGCACACCAGA	0.582000													11	11					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167645468	167645468	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:167645468C>T	ENST00000519204.1	+	22	4327	c.4209C>T	c.(4207-4209)aaC>aaT	p.N1403N	TENM2_ENST00000403607.2_Silent_p.N1348N|TENM2_ENST00000545108.1_Silent_p.N1523N|TENM2_ENST00000520394.1_Silent_p.N1285N|TENM2_ENST00000518659.1_Silent_p.N1524N					teneurin transmembrane protein 2																		ACTGCAAAAACGATGTCAATT	0.493000													41	86					0	0	1	0	0
BHLHE40	8553	broad.mit.edu	37	3	5025136	5025136	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:5025136C>A	ENST00000256495.3	+	5	1601	c.998C>A	c.(997-999)aCt>aAt	p.T333N		NM_003670.2	NP_003661.1	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	333						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(2)	12						CCTTCAGCGACTGCCTACCTG	0.597000													15	31					2.32078e-09	2.46314e-09	1	1	0
SGSM1	129049	broad.mit.edu	37	22	25315923	25315923	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:25315923C>T	ENST00000400358.4	+	24	3213	c.3156C>T	c.(3154-3156)aaC>aaT	p.N1052N	SGSM1_ENST00000400359.4_Silent_p.N1107N	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	1107	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						TTTTGGAGAACAACATGGATT	0.527000													5	14					0	0	1	0	0
LGR4	55366	broad.mit.edu	37	11	27395187	27395187	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:27395187C>T	ENST00000379214.4	-	15	1733	c.1290G>A	c.(1288-1290)acG>acA	p.T430T	LGR4_ENST00000389858.4_Silent_p.T406T	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	430						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						TCAGGCCTTCCGTAGGAAAGG	0.358000													29	41					0	0	1	0	0
FGFR1OP	11116	broad.mit.edu	37	6	167416734	167416734	+	Splice_Site	SNP	C	C	T	rs146065090	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:167416734C>T	ENST00000366847.3	+	3	441	c.211_splice	c.e3+1	p.D70_splice	FGFR1OP_ENST00000476078.1_3'UTR|FGFR1OP_ENST00000349556.4_Splice_Site_p.D70_splice	NM_007045.2	NP_008976.1	O95684	FR1OP_HUMAN	FGFR1 oncogene partner	70	LisH.				G2/M transition of mitotic cell cycle|microtubule anchoring|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation	centrosome|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity|protein kinase binding|protein tyrosine kinase inhibitor activity			large_intestine(2)|ovary(1)|stomach(1)	4		Breast(66;1.48e-05)|Ovarian(120;0.0607)		OV - Ovarian serous cystadenocarcinoma(33;1.73e-19)|BRCA - Breast invasive adenocarcinoma(81;5.1e-06)|GBM - Glioblastoma multiforme(31;0.00231)		ATACCAAAGACGGTAAGATGT	0.294000			T	FGFR1	"""MPD, NHL"""								13	46					0	0	1	0	0
PPP6C	5537	broad.mit.edu	37	9	127916001	127916001	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:127916001C>T	ENST00000451402.1	-	7	811	c.591G>A	c.(589-591)ttG>ttA	p.L197L	PPP6C_ENST00000373547.4_Silent_p.L160L|PPP6C_ENST00000415905.1_Silent_p.L138L|PPP6C_ENST00000373546.3_Silent_p.L13L	NM_001123355.1	NP_001116827.1	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit	160					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			NS(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(3)	14						CATGGACACACAAAATCTGCT	0.353000													17	35					0	0	1	0	0
WDR24	84219	broad.mit.edu	37	16	736980	736980	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:736980G>A	ENST00000293883.4	-	3	1855	c.1096C>T	c.(1096-1098)Cgc>Tgc	p.R366C	WDR24_ENST00000248142.6_Missense_Mutation_p.R496C	NM_032259.2	NP_115635.1	Q96S15	WDR24_HUMAN	WD repeat domain 24	496										breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(3)	19		Hepatocellular(780;0.0218)				TAGGGCTTGCGCCCCGACTCG	0.697000													7	5					0	0	1	0	0
GPR75	10936	broad.mit.edu	37	2	54080776	54080776	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:54080776G>T	ENST00000394705.2	-	2	1388	c.1118C>A	c.(1117-1119)cCt>cAt	p.P373H	GPR75-ASB3_ENST00000352846.3_Intron|ASB3_ENST00000498475.2_Intron|ASB3_ENST00000406625.2_Intron	NM_006794.3	NP_006785.1	O95800	GPR75_HUMAN	G protein-coupled receptor 75	373						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ATATATAAAAGGGTTTAATCC	0.418000													14	53					1.49906e-05	1.54943e-05	1	1	0
MCM2	4171	broad.mit.edu	37	3	127337956	127337956	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:127337956C>T	ENST00000265056.7	+	13	2344	c.2100C>T	c.(2098-2100)agC>agT	p.S700S	MCM2_ENST00000468414.1_3'UTR	NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	700					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						CCAATGGCAGCGCTGCTGAGC	0.627000													3	9					0	0	1	0	0
SGK223	0	broad.mit.edu	37	8	8175899	8175899	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:8175899C>T	ENST00000520004.1	-	6	4250	c.3986G>A	c.(3985-3987)cGg>cAg	p.R1329Q	SGK223_ENST00000330777.4_Missense_Mutation_p.R1329Q			Q86YV5	SG223_HUMAN		1329							ATP binding|non-membrane spanning protein tyrosine kinase activity										CAGCTCGCGCCGAGGCCCCCA	0.657000													23	43					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241465186	241465186	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:241465186C>T	ENST00000391987.1	-	7	1350	c.984G>A	c.(982-984)acG>acA	p.T328T	ANKMY1_ENST00000373318.2_Silent_p.T187T|ANKMY1_ENST00000373320.4_Silent_p.T98T|ANKMY1_ENST00000403283.1_Silent_p.T266T|ANKMY1_ENST00000536462.1_Silent_p.T140T|ANKMY1_ENST00000401804.1_Silent_p.T417T|ANKMY1_ENST00000406958.1_Silent_p.T187T|ANKMY1_ENST00000361678.4_Silent_p.T187T|ANKMY1_ENST00000272972.3_Silent_p.T328T|ANKMY1_ENST00000405523.3_Silent_p.T187T|ANKMY1_ENST00000405002.1_Silent_p.T98T			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	328							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TGCTGAGTGCCGTGAGACCCT	0.592000													6	21					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176004552	176004552	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176004552G>A	ENST00000510636.1	+	13	1621	c.1347G>A	c.(1345-1347)gtG>gtA	p.V449V	CDHR2_ENST00000506348.1_Silent_p.V449V|CDHR2_ENST00000261944.5_Silent_p.V449V	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	449	Cadherin 4.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CGATGGCGGTGCAGGTGAGGG	0.697000													6	14					0	0	1	0	0
SH3BP2	6452	broad.mit.edu	37	4	2831831	2831831	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2831831G>A	ENST00000356331.5	+	8	1459	c.1198G>A	c.(1198-1200)Gca>Aca	p.A400T	SH3BP2_ENST00000442312.2_Missense_Mutation_p.A428T|SH3BP2_ENST00000452765.2_Missense_Mutation_p.A400T|SH3BP2_ENST00000503393.2_Missense_Mutation_p.A457T|SH3BP2_ENST00000511747.1_Missense_Mutation_p.A400T|SH3BP2_ENST00000435136.2_Missense_Mutation_p.A400T	NM_003023.4	NP_003014.3	P78314	3BP2_HUMAN	SH3-domain binding protein 2	400					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		GGCGCGGCCCGCAGTCCTGCC	0.711000									Cherubism				5	17					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84270517	84270517	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:84270517C>T	ENST00000568181.1	-	2	695	c.575G>A	c.(574-576)cGc>cAc	p.R192H	KCNG4_ENST00000308251.4_Missense_Mutation_p.R192H			Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	192						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						CGAGGCGGGGCGGCGGGTCTC	0.682000													16	18					0	0	1	0	0
NLGN2	57555	broad.mit.edu	37	17	7317668	7317668	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7317668C>T	ENST00000302926.2	+	3	587	c.514C>T	c.(514-516)Cgt>Tgt	p.R172C	NLGN2_ENST00000575301.1_Missense_Mutation_p.R172C	NM_020795.2	NP_065846.1	Q8NFZ4	NLGN2_HUMAN	neuroligin 2	172					cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|prostate(2)|skin(3)	22		Prostate(122;0.157)				CACAGATATCCGTGACCCTGG	0.627000													6	6					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16359569	16359569	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:16359569G>A	ENST00000354981.2	-	19	3235	c.3078C>T	c.(3076-3078)ggC>ggT	p.G1026G	KIF16B_ENST00000378003.2_Silent_p.G252G|KIF16B_ENST00000408042.1_Silent_p.G1026G|KIF16B_ENST00000355755.3_Silent_p.G1026G	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	1026	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						CAATCTCCATGCCCAGGGTGG	0.612000													10	49					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67688513	67688513	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67688513G>A	ENST00000334583.6	+	31	3828	c.3500G>A	c.(3499-3501)cGc>cAc	p.R1167H	RLTPR_ENST00000545661.1_Missense_Mutation_p.R1131H	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	1167										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		AGCCGACCTCGCTACACAAGA	0.657000													14	14					0	0	1	0	0
ZDHHC2	51201	broad.mit.edu	37	8	17055160	17055160	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:17055160A>G	ENST00000262096.8	+	5	1138	c.443_splice	c.e5+1	p.K148_splice		NM_016353.4	NP_057437.1	Q9UIJ5	ZDHC2_HUMAN	zinc finger, DHHC-type containing 2	148						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|pancreas(1)|stomach(1)	8				Colorectal(111;0.0697)|COAD - Colon adenocarcinoma(73;0.244)		GTCTGTGATAAGTAAGAGAAC	0.388000													28	47					0	0	1	0	0
ZBTB17	7709	broad.mit.edu	37	1	16269097	16269097	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16269097G>A	ENST00000375733.2	-	14	2203	c.1965C>T	c.(1963-1965)agC>agT	p.S655S	ZBTB17_ENST00000375743.4_Silent_p.S655S|ZBTB17_ENST00000537142.1_Silent_p.S573S			Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	655	Interaction with HCFC1.|Interaction with MYC.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)	15		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTGACCACGCTGACCTCAC	0.637000													5	29					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166243467	166243467	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166243467A>G	ENST00000357398.3	+	26	5053	c.4763A>G	c.(4762-4764)tAc>tGc	p.Y1588C	SCN2A_ENST00000375427.2_Missense_Mutation_p.Y1588C|SCN2A_ENST00000283256.6_Missense_Mutation_p.Y1588C|SCN2A_ENST00000375437.2_Missense_Mutation_p.Y1588C			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1588					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CTTCGTTACTACTATTTCACT	0.358000													4	65					0	0	1	0	0
TTLL7	79739	broad.mit.edu	37	1	84408190	84408190	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:84408190G>A	ENST00000260505.8	-	7	1056	c.679C>T	c.(679-681)Cga>Tga	p.R227*	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	227	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		GTACCCATTCGCACAAGCCCA	0.363000													28	33					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803961	23803961	+	Missense_Mutation	SNP	C	C	T	rs143962880		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:23803961C>T	ENST00000264867.2	-	11	2146	c.2027G>A	c.(2026-2028)cGc>cAc	p.R676H	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	676					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				AATCACACGGCGCTCTTCCTA	0.502000													30	45					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182347362	182347362	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:182347362A>G	ENST00000397033.2	+	9	1455	c.1025A>G	c.(1024-1026)tAc>tGc	p.Y342C		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	342					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GTGTTTGTGTACATCAACTCT	0.473000													15	74					0	0	1	0	0
SLC13A4	26266	broad.mit.edu	37	7	135392945	135392945	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:135392945G>A	ENST00000354042.4	-	3	971	c.282C>T	c.(280-282)tgC>tgT	p.C94C	AC091736.10_ENST00000378428.3_RNA	NM_012450.2	NP_036582.2	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 4	94						integral to plasma membrane	sodium:sulfate symporter activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	24						CAGCCGCCACGCAGATGACCC	0.607000													45	61					0	0	1	0	0
DEFA4	1669	broad.mit.edu	37	8	6794283	6794283	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:6794283C>T	ENST00000297435.2	-	2	263	c.139G>A	c.(139-141)Gca>Aca	p.A47T		NM_001925.1	NP_001916.1	P12838	DEF4_HUMAN	defensin, alpha 4, corticostatin	47					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	10				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		TTATCCCATGCAAAGGAAATA	0.557000													11	38					0	0	1	0	0
HCN2	610	broad.mit.edu	37	19	603876	603876	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:603876C>T	ENST00000251287.2	+	2	1018	c.965C>T	c.(964-966)gCc>gTc	p.A322V		NM_001194.3	NP_001185.3	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	322					cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			endometrium(5)|lung(4)	9		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGGCACGCGCCCTGCGCATC	0.607000													5	28					0	0	1	0	0
PSMD7	5713	broad.mit.edu	37	16	74334038	74334038	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:74334038C>T	ENST00000219313.4	+	2	240	c.100C>T	c.(100-102)Cgt>Tgt	p.R34C	PSMD7_ENST00000567958.1_Missense_Mutation_p.R34C|PSMD7_ENST00000568615.2_Missense_Mutation_p.R34C|PSMD7_ENST00000540379.1_5'UTR	NM_002811.4	NP_002802.2	P51665	PSD7_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	34	MPN.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)	15						AAACCAGAAGCGTGTTGTTGG	0.413000													20	29					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5214594	5214594	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5214594G>A	ENST00000372412.4	-	29	4708	c.4475C>T	c.(4474-4476)aCg>aTg	p.T1492M	PTPRS_ENST00000588012.1_Missense_Mutation_p.T1453M|PTPRS_ENST00000587303.1_Missense_Mutation_p.T1491M|PTPRS_ENST00000592099.1_Missense_Mutation_p.T1044M|PTPRS_ENST00000348075.2_Missense_Mutation_p.T1453M|PTPRS_ENST00000262963.6_Missense_Mutation_p.T1471M|PTPRS_ENST00000357368.4_Missense_Mutation_p.T1491M|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000353284.2_Missense_Mutation_p.T1044M			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1491	Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CTCCAGCCGCGTCATCATGAC	0.637000													9	16					0	0	1	0	0
MTMR3	8897	broad.mit.edu	37	22	30418109	30418109	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:30418109T>C	ENST00000401950.2	+	18	3659	c.3317T>C	c.(3316-3318)gTg>gCg	p.V1106A	MTMR3_ENST00000323630.5_Missense_Mutation_p.V970A|MTMR3_ENST00000351488.3_Intron|CTA-85E5.10_ENST00000429350.1_RNA|MTMR3_ENST00000406629.1_Intron|MTMR3_ENST00000333027.3_Intron	NM_021090.3	NP_066576.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	1106					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TGGGAGCAGGTGGATAAACAG	0.517000													22	18					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10235523	10235523	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:10235523C>T	ENST00000418404.3	-	19	2354	c.2191G>A	c.(2191-2193)Gcc>Acc	p.A731T	MYH13_ENST00000570743.1_Missense_Mutation_p.A731T|MYH13_ENST00000252172.4_Missense_Mutation_p.A731T|RP11-401O9.3_ENST00000577743.1_RNA			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	731	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						ATAGCACTGGCATTGAGGATC	0.507000													26	38					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10699862	10699862	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:10699862G>A	ENST00000377022.3	-	21	4734	c.4417C>T	c.(4417-4419)Cac>Tac	p.H1473Y	RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	1473					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TTGTACATGTGCGTGCGCCCG	0.607000													4	10					0	0	1	0	0
RAI14	26064	broad.mit.edu	37	5	34814747	34814747	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:34814747G>A	ENST00000265109.3	+	12	1199	c.912G>A	c.(910-912)tcG>tcA	p.S304S	RAI14_ENST00000397449.1_Silent_p.S297S|RAI14_ENST00000428746.2_Silent_p.S304S|RAI14_ENST00000515799.1_Silent_p.S307S|RAI14_ENST00000503673.1_Silent_p.S304S|RAI14_ENST00000512629.1_Silent_p.S275S|RAI14_ENST00000506376.1_Silent_p.S296S	NM_001145522.1|NM_015577.2	NP_001138994.1|NP_056392.2	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14	304						cell cortex|cytoskeleton	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(19)|lung(22)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(31;0.000191)					GAAAGGAATCGGTATTTTTTG	0.318000													25	39					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104474749	104474749	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:104474749G>T	ENST00000409874.4	+	20	2100		c.e20-1		TDRD9_ENST00000339063.5_Splice_Site	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9						cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				TATATTTAAAGGATGAACTTA	0.259000													6	40					0.00198382	0.0020125	1	1	0
CES4A	283848	broad.mit.edu	37	16	67038065	67038065	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67038065G>A	ENST00000540947.2	+	9	1202	c.1018G>A	c.(1018-1020)Gtt>Att	p.V340I	CES4A_ENST00000540579.1_Missense_Mutation_p.V242I|CES4A_ENST00000398354.1_Missense_Mutation_p.V340I|CES4A_ENST00000541479.1_Missense_Mutation_p.V363I|CES4A_ENST00000535696.1_Missense_Mutation_p.V246I|CES4A_ENST00000338718.4_Missense_Mutation_p.V363I|CES4A_ENST00000326686.5_Missense_Mutation_p.V340I	NM_173815.6	NP_776176.5	Q5XG92	EST4A_HUMAN	carboxylesterase 4A	340						extracellular region	carboxylesterase activity			large_intestine(2)|liver(2)|lung(4)|ovary(1)	9						CCAGGGGAAGGTTTCATCTGT	0.498000													41	52					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120437245	120437245	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:120437245G>A	ENST00000369400.1	-	1	1873	c.1715C>T	c.(1714-1716)aCg>aTg	p.T572M		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	572	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		AATTATAGTCGTATGCTCTGG	0.398000													42	73					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118221659	118221659	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:118221659A>G	ENST00000402510.2	-	11	3533	c.3534T>C	c.(3532-3534)gcT>gcC	p.A1178A		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	1178										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TGCCTTCAACAGCCATTTTCT	0.458000													11	3					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95186038	95186038	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:95186038C>T	ENST00000354268.4	+	10	1535	c.1462C>T	c.(1462-1464)Cct>Tct	p.P488S	SMARCAD1_ENST00000509418.1_Missense_Mutation_p.P58S|SMARCAD1_ENST00000457823.2_Missense_Mutation_p.P488S			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	488					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		CATAGAACAACCTTCCATTCT	0.303000													5	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179623769	179623769	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179623769C>T	ENST00000589042.1	-	44	10469	c.10245G>A	c.(10243-10245)acG>acA	p.T3415T	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Silent_p.T3369T|TTN_ENST00000360870.5_Silent_p.T3415T|TTN_ENST00000591111.1_Silent_p.T3415T|TTN_ENST00000460472.2_Silent_p.T3369T|TTN_ENST00000342992.6_Silent_p.T3415T|TTN_ENST00000359218.5_Silent_p.T3369T|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3128	Ig-like 20.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGCAACAAACGTGTAAGTTC	0.388000													34	40					0	0	1	0	0
KLHL9	55958	broad.mit.edu	37	9	21334742	21334742	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:21334742G>A	ENST00000359039.4	-	1	637	c.117C>T	c.(115-117)ggC>ggT	p.G39G	KLHL9_ENST00000537938.1_Intron			Q9P2J3	KLHL9_HUMAN	kelch-like family member 9	39					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				endometrium(9)|large_intestine(7)|lung(10)|ovary(4)|skin(2)	32				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		GCTGATCAAAGCCTTGCAATA	0.483000													33	31					0	0	1	0	0
TIMM22	29928	broad.mit.edu	37	17	902045	902045	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:902045G>A	ENST00000327158.3	+	2	291	c.265G>A	c.(265-267)Gtg>Atg	p.V89M		NM_013337.2	NP_037469.2	Q9Y584	TIM22_HUMAN	translocase of inner mitochondrial membrane 22 homolog (yeast)	89					transmembrane transport	integral to membrane|mitochondrial inner membrane	protein transporter activity			breast(2)|endometrium(2)|large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		TGCATTTGGGGTGTTTACCGC	0.483000													42	72					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143618432	143618432	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:143618432G>A	ENST00000517894.1	+	26	4549	c.3655G>A	c.(3655-3657)Gcc>Acc	p.A1219T	BAI1_ENST00000323289.5_Missense_Mutation_p.A1219T			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1219					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GAACGGCCACGCCCAGCTCAT	0.687000													7	5					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10276298	10276298	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:10276298G>A	ENST00000256458.4	+	11	1518	c.1428G>A	c.(1426-1428)acG>acA	p.T476T		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	476	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						CCCTGGCCACGGCTGCCTGCC	0.687000													15	42					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31810746	31810746	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:31810746C>T	ENST00000446923.2	+	7	2826	c.2435C>T	c.(2434-2436)gCg>gTg	p.A812V	ZEB1_ENST00000560721.2_Missense_Mutation_p.A808V|ZEB1_ENST00000320985.10_Missense_Mutation_p.A828V|ZEB1_ENST00000361642.5_Missense_Mutation_p.A829V|ZEB1_ENST00000542815.3_Missense_Mutation_p.A761V|ZEB1_ENST00000559858.1_3'UTR	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	828					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TGCTTAAGAGCGCTAGCTGCC	0.502000													23	26					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47753783	47753783	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:47753783G>A	ENST00000398545.4	-	8	1630	c.1513C>T	c.(1513-1515)Cgc>Tgc	p.R505C		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	505										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		CATGCCTTGCGCATGGGATGA	0.443000													15	26					0	0	1	0	0
CEACAM18	729767	broad.mit.edu	37	19	51981850	51981850	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:51981850C>T	ENST00000451626.1	+	2	137	c.137C>T	c.(136-138)gCt>gTt	p.A46V				A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	46						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GAGGAGGTGGCTGTGTCTCTG	0.642000													9	9					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160309737	160309737	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160309737G>A	ENST00000241704.7	-	3	419	c.190C>T	c.(190-192)Cca>Tca	p.P64S	COPA_ENST00000368069.3_Missense_Mutation_p.P64S	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	64					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACGAACAGTGGCTGCTGCTTA	0.458000													23	35					0	0	1	0	0
ASB6	140459	broad.mit.edu	37	9	132400656	132400656	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:132400656C>A	ENST00000277458.4	-	6	844	c.679G>T	c.(679-681)Ggg>Tgg	p.G227W	ASB6_ENST00000450050.2_Missense_Mutation_p.G148W|ASB6_ENST00000277459.4_Missense_Mutation_p.E190D	NM_017873.3	NP_060343.1	Q9NWX5	ASB6_HUMAN	ankyrin repeat and SOCS box containing 6	227					intracellular signal transduction	cytoplasm				NS(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)	15		Ovarian(14;0.00556)				TCTTTGTCCCCTCCCACGGTC	0.597000													15	39					8.60227e-14	9.36079e-14	1	1	0
COL4A3BP	10087	broad.mit.edu	37	5	74676896	74676896	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:74676896C>T	ENST00000380494.5	-	17	2425		c.e17+1		COL4A3BP_ENST00000508692.1_Intron|COL4A3BP_ENST00000261415.7_Splice_Site|COL4A3BP_ENST00000405807.4_Splice_Site	NM_001130105.1	NP_001123577.1	Q9Y5P4	C43BP_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein						ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			breast(1)|kidney(1)|large_intestine(5)|lung(4)|skin(3)|stomach(1)|urinary_tract(1)	16		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		AAAATACATACCATTAGCTAC	0.353000													27	51					0	0	1	0	0
ZNF112	7665	broad.mit.edu	37	19	44833243	44833243	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44833243T>C	ENST00000354340.4	-	4	1118	c.1067A>G	c.(1066-1068)aAc>aGc	p.N356S	ZNF112_ENST00000337401.4_Missense_Mutation_p.N362S|ZNF112_ENST00000536500.1_Missense_Mutation_p.N379S	NM_013380.3	NP_037512.3			zinc finger protein 112																		CTCATAAATGTTGTGCCTATA	0.388000													16	56					0	0	1	0	0
CRYGD	1421	broad.mit.edu	37	2	208986563	208986563	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:208986563T>C	ENST00000264376.4	-	3	386	c.359A>G	c.(358-360)gAa>gGa	p.E120G		NM_006891.3	NP_008822.2	P07320	CRGD_HUMAN	crystallin, gamma D	120	Beta/gamma crystallin 'Greek key' 3.				cellular response to reactive oxygen species|visual perception	soluble fraction	protein binding|structural constituent of eye lens			breast(1)|endometrium(1)|lung(3)	5				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		GGAGTGGATTTCATTGAAGCG	0.557000													31	58					0	0	1	0	0
SEPT7	989	broad.mit.edu	37	7	35913364	35913364	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:35913364T>C	ENST00000494488.2	+	5	449	c.449T>C	c.(448-450)tTc>tCc	p.F150S	SEPT7_ENST00000399034.2_Missense_Mutation_p.F165S|SEPT7_ENST00000350320.6_Missense_Mutation_p.F163S|SEPT7_ENST00000435235.1_Missense_Mutation_p.F111S|SEPT7_ENST00000469679.2_Missense_Mutation_p.F163S|SEPT7_ENST00000399035.3_Missense_Mutation_p.F163S|SEPT7_ENST00000475109.1_3'UTR			Q16181	SEPT7_HUMAN	septin 7	164					cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)	14						TGTTTATACTTCATTGCTCCT	0.383000													33	125					0	0	1	0	0
RBBP4	5928	broad.mit.edu	37	1	33123147	33123147	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33123147C>T	ENST00000373493.5	+	3	443	c.284C>T	c.(283-285)gCg>gTg	p.A95V	RBBP4_ENST00000414241.3_Missense_Mutation_p.A94V|RBBP4_ENST00000458695.2_Missense_Mutation_p.A60V|RBBP4_ENST00000373485.1_Missense_Mutation_p.A95V|RBBP4_ENST00000544435.1_Intron|RBBP4_ENST00000524393.1_Intron	NM_001135255.1|NM_005610.2	NP_001128727.1|NP_005601.1	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4	95					cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CAGTTTGATGCGTCACACTAC	0.423000													20	34					0	0	1	0	0
GNB1L	0	broad.mit.edu	37	22	19776365	19776365	+	Missense_Mutation	SNP	G	G	A	rs73148914	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19776365G>A	ENST00000329517.6	-	8	1087	c.851C>T	c.(850-852)aCg>aTg	p.T284M	GNB1L_ENST00000460402.1_5'UTR|GNB1L_ENST00000405009.1_Intron|GNB1L_ENST00000403325.1_Missense_Mutation_p.T284M	NM_053004.2	NP_443730.1	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	284					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	12	Colorectal(54;0.0993)					TGGCTGCATCGTCCGCCAGTG	0.687000													10	18					0	0	1	0	0
AP2A1	160	broad.mit.edu	37	19	50304787	50304787	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50304787C>T	ENST00000354293.5	+	13	1860	c.1694C>T	c.(1693-1695)gCc>gTc	p.A565V	AP2A1_ENST00000359032.5_Missense_Mutation_p.A565V	NM_130787.2	NP_570603.2	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1 subunit	565					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)	19		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		GTCCTGCGGGCCGGCTCCCAG	0.662000													16	37					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121458730	121458730	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:121458730G>A	ENST00000260197.7	+	28	3945	c.3814_splice	c.e28-1	p.E1272_splice	SORL1_ENST00000525532.1_Splice_Site_p.E216_splice|SORL1_ENST00000532694.1_Splice_Site_p.E118_splice|SORL1_ENST00000534286.1_Splice_Site_p.E182_splice	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1272	LDL-receptor class A 5.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CCCTTACAGAGCCCCTCTGTA	0.587000													11	24					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71339748	71339748	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:71339748C>T	ENST00000413702.1	+	3	298	c.10C>T	c.(10-12)Ctg>Ttg	p.L4L	MUC7_ENST00000304887.5_Silent_p.L4L|MUC7_ENST00000514512.1_Intron|MUC7_ENST00000456088.1_Silent_p.L4L	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	4						extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			AATGAAAACTCTGCCGCTGTT	0.373000													9	44					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36039601	36039601	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:36039601C>T	ENST00000282507.3	-	5	1154	c.1053G>A	c.(1051-1053)tgG>tgA	p.W351*	UGT3A2_ENST00000513300.1_Nonsense_Mutation_p.W317*|UGT3A2_ENST00000545528.1_Nonsense_Mutation_p.W49*	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	351						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCTGAGGAAGCCAGTCCACAA	0.542000													16	33					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79890990	79890990	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:79890990G>A	ENST00000360280.3	+	26	2937	c.2677G>A	c.(2677-2679)Gag>Aag	p.E893K	VPS13A_ENST00000357409.5_Missense_Mutation_p.E893K|VPS13A_ENST00000376634.4_Missense_Mutation_p.E893K|VPS13A_ENST00000376636.3_Missense_Mutation_p.E893K	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	893					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GGTTTTGATCGAGTTTTATCA	0.328000													8	42					0	0	1	0	0
NIPAL4	348938	broad.mit.edu	37	5	156899810	156899810	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:156899810G>A	ENST00000311946.7	+	6	1359	c.1243G>A	c.(1243-1245)Gcc>Acc	p.A415T	NIPAL4_ENST00000435489.2_Missense_Mutation_p.A396T|ADAM19_ENST00000430702.2_Intron	NM_001099287.1	NP_001092757.1	Q0D2K0	NIPA4_HUMAN	NIPA-like domain containing 4	415						integral to membrane	receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|skin(1)	22						CATCAGCTGCGCCAGCTTGCC	0.537000													15	17					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70367895	70367895	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:70367895C>T	ENST00000374051.3	+	2	618	c.296C>T	c.(295-297)gCc>gTc	p.A99V	NLGN3_ENST00000536169.1_Missense_Mutation_p.A99V|NLGN3_ENST00000358741.3_Missense_Mutation_p.A99V	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	99					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					ATCCGGAACGCCACACACTTT	0.617000													12	5					0	0	1	0	0
SLC30A5	64924	broad.mit.edu	37	5	68410309	68410309	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:68410309G>A	ENST00000396591.3	+	7	1208	c.598G>A	c.(598-600)Gtg>Atg	p.V200M	CTC-498J12.3_ENST00000504129.1_RNA	NM_022902.4	NP_075053.2	Q8TAD4	ZNT5_HUMAN	solute carrier family 30 (zinc transporter), member 5	200					cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		CTTCTTAGGTGTGGCAGATCA	0.338000													24	29					0	0	1	0	0
NFKB1	4790	broad.mit.edu	37	4	103514669	103514669	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:103514669G>A	ENST00000226574.4	+	12	1621	c.1154G>A	c.(1153-1155)gGc>gAc	p.G385D	NFKB1_ENST00000600343.1_Missense_Mutation_p.G204D|NFKB1_ENST00000505458.1_Missense_Mutation_p.G384D|NFKB1_ENST00000394820.4_Missense_Mutation_p.G384D	NM_001165412.1|NM_003998.3	NP_001158884.1|NP_003989.2	P19838	NFKB1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	384	GRR.|Gly-rich.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			biliary_tract(1)|breast(4)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	GGAGCTGGAGGCGGAGGCATG	0.468000													6	91					0	0	1	0	0
NR4A3	0	broad.mit.edu	37	9	102626117	102626117	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:102626117G>A	ENST00000330847.1	+	7	1926	c.1882G>A	c.(1882-1884)Gac>Aac	p.D628N	NR4A3_ENST00000395097.2_Missense_Mutation_p.D617N			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	617					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				TTCCATCATTGACAAGCTCTT	0.557000			T	EWSR1	extraskeletal myxoid chondrosarcoma								20	24					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997287	115997287	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:115997287C>T	ENST00000264363.2	-	2	1584	c.906G>A	c.(904-906)agG>agA	p.R302R		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	302	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CAAGGATGTACCTGTCCAAGG	0.403000													24	48					0	0	1	0	0
PCDHB15	0	broad.mit.edu	37	5	140627138	140627138	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140627138C>T	ENST00000231173.3	+	1	1992	c.1992C>T	c.(1990-1992)gaC>gaT	p.D664D		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		664	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTGGTGGACGGCTTCTCTC	0.687000													22	36					0	0	1	0	0
DLK2	65989	broad.mit.edu	37	6	43418773	43418773	+	Missense_Mutation	SNP	C	C	T	rs146272567	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43418773C>T	ENST00000357338.3	-	6	1356	c.656G>A	c.(655-657)cGc>cAc	p.R219H	DLK2_ENST00000414245.1_Missense_Mutation_p.R213H|DLK2_ENST00000372485.1_Missense_Mutation_p.R213H|DLK2_ENST00000372488.3_Missense_Mutation_p.R219H	NM_206539.1	NP_996262.1	Q6UY11	DLK2_HUMAN	delta-like 2 homolog (Drosophila)	219	EGF-like 6; calcium-binding (Potential).					integral to membrane	calcium ion binding	p.R219H(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CTGGCATGGGCGGCTGGCACA	0.617000													13	31					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868711	97868711	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:97868711G>A	ENST00000437310.1	+	1	542	c.482G>A	c.(481-483)gGa>gAa	p.G161E		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						ATCCATGAAGGATTTTTATTC	0.348000													49	119					0	0	1	0	0
C11orf58	10944	broad.mit.edu	37	11	16760273	16760273	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:16760273G>A	ENST00000228136.4	+	0	326				C11orf58_ENST00000422258.2_De_novo_Start_OutOfFrame|C11orf58_ENST00000527893.1_Intron|C11orf58_ENST00000525684.1_De_novo_Start_OutOfFrame			O00193	SMAP_HUMAN	chromosome 11 open reading frame 58											NS(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)	7						TGGTTTTGCGGCTGGGAAGAG	0.627000													11	24					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60695920	60695920	+	Missense_Mutation	SNP	C	C	T	rs148400140		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:60695920C>T	ENST00000335712.6	-	3	661	c.434G>A	c.(433-435)gGa>gAa	p.G145E	BCL11A_ENST00000537768.1_5'UTR|BCL11A_ENST00000356842.4_Missense_Mutation_p.G145E|BCL11A_ENST00000359629.5_Missense_Mutation_p.G145E|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000358510.4_Intron|BCL11A_ENST00000538214.1_Intron	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	145	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GATTAGAGCTCCATGTGCAGA	0.468000			T	IGH@	B-CLL								11	25					0	0	1	0	0
TTLL11	158135	broad.mit.edu	37	9	124751448	124751448	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:124751448G>A	ENST00000373776.3	-	4	1752	c.1565C>T	c.(1564-1566)gCg>gTg	p.A522V	TTLL11_ENST00000321582.5_Intron|TTLL11_ENST00000474723.1_Intron	NM_194252.2	NP_919228.2	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	522	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(3)|skin(1)	18						GGCTGGAAACGCAGGCTGGGA	0.617000													18	40					0	0	1	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64722867	64722867	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:64722867C>T	ENST00000338957.4	+	5	2356	c.2289C>T	c.(2287-2289)agC>agT	p.S763S	ZC3H12B_ENST00000423889.3_Silent_p.S752S	NM_001010888.3	NP_001010888.3	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	752							endonuclease activity|nucleic acid binding|zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TGGTACGGAGCGTGCCTGAAA	0.512000													21	3					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155776897	155776897	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:155776897G>A	ENST00000159060.2	-	1	140	c.38C>T	c.(37-39)aCc>aTc	p.T13I		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	13							electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		TACTAATATGGTGGAGAGACC	0.368000													23	37					0	0	1	0	0
MEIS2	4212	broad.mit.edu	37	15	37388508	37388508	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:37388508G>A	ENST00000338564.5	-	4	815	c.369C>T	c.(367-369)atC>atT	p.I123I	MEIS2_ENST00000382766.2_Silent_p.I123I|MEIS2_ENST00000561208.1_Silent_p.I123I|MEIS2_ENST00000397624.3_Silent_p.I35I|MEIS2_ENST00000340545.5_Silent_p.I110I|MEIS2_ENST00000397620.2_Silent_p.I35I|MEIS2_ENST00000219869.9_Intron|MEIS2_ENST00000444725.1_Silent_p.I123I|MEIS2_ENST00000424352.2_Silent_p.I123I|MEIS2_ENST00000559561.1_Silent_p.I123I|MEIS2_ENST00000559085.1_Silent_p.I110I|MEIS2_ENST00000557796.2_Silent_p.I110I	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	123					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		CGAAGACCGCGATGTCCTCGT	0.597000													3	6					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151749738	151749738	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:151749738C>T	ENST00000535741.1	-	30	5238	c.4765G>A	c.(4765-4767)Gca>Aca	p.A1589T	LRBA_ENST00000357115.3_Missense_Mutation_p.A1589T|LRBA_ENST00000507224.1_Missense_Mutation_p.A1589T|LRBA_ENST00000510413.1_Missense_Mutation_p.A1589T			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1589						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TCCACTGATGCCGTAGTTAAA	0.403000													27	192					0	0	1	0	0
FAM129B	64855	broad.mit.edu	37	9	130269199	130269199	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130269199C>A	ENST00000373312.3	-	14	2379	c.2166G>T	c.(2164-2166)caG>caT	p.Q722H	FAM129B_ENST00000373314.3_Missense_Mutation_p.Q709H	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	722							protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						GGCTGGACACCTGCTCTCCAG	0.677000													22	27					9.95505e-16	1.0907e-15	1	1	0
OXCT1	5019	broad.mit.edu	37	5	41762226	41762226	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:41762226T>C	ENST00000196371.5	-	14	1485	c.1325A>G	c.(1324-1326)gAg>gGg	p.E442G	OXCT1_ENST00000510634.1_Missense_Mutation_p.E45G|OXCT1_ENST00000513081.1_5'UTR|OXCT1_ENST00000509987.1_Missense_Mutation_p.E256G|OXCT1_ENST00000512084.1_Missense_Mutation_p.E45G	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	442					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	TGCAGAATGCTCCATGGTGAC	0.438000													6	111					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7064751	7064751	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7064751G>A	ENST00000299481.4	+	4	1840	c.1494G>A	c.(1492-1494)tgG>tgA	p.W498*		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	498	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AAGGCAGTTGGGAAGCTGGGA	0.413000													21	44					0	0	1	0	0
GINS2	51659	broad.mit.edu	37	16	85712249	85712249	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:85712249G>A	ENST00000253462.3	-	4	429	c.329C>T	c.(328-330)gCa>gTa	p.A110V		NM_016095.2	NP_057179.1	Q9Y248	PSF2_HUMAN	GINS complex subunit 2 (Psf2 homolog)	110					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	nucleoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)	6						GATTTCGTCTGCCTTCGGGAT	0.517000													39	58					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79749720	79749720	+	Missense_Mutation	SNP	C	C	T	rs148542288		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:79749720C>T	ENST00000305428.3	+	2	1306	c.1231C>T	c.(1231-1233)Cgc>Tgc	p.R411C		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	411						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						CCCAGAAAGGCGCCCAACTTA	0.478000													19	32					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31653919	31653919	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:31653919C>A	ENST00000395934.2	+	7	901	c.894C>A	c.(892-894)gcC>gcA	p.A298A	ELP4_ENST00000379163.5_Silent_p.A299A|ELP4_ENST00000350638.5_Silent_p.A298A			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	298					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					CTCTTTCAGCCTGCATCATCA	0.413000													21	30					1.28384e-07	1.34682e-07	1	1	0
SORCS3	22986	broad.mit.edu	37	10	106976777	106976777	+	Silent	SNP	C	C	T	rs143982937	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:106976777C>T	ENST00000369701.3	+	19	2858	c.2631C>T	c.(2629-2631)gaC>gaT	p.D877D	SORCS3_ENST00000369699.4_Silent_p.D163D	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	877	PKD.					integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CCATCGAGGACGGCATCAAGC	0.527000													30	45					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160385872	160385872	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160385872G>A	ENST00000368061.2	+	3	566	c.92G>A	c.(91-93)cGc>cAc	p.R31H		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	31					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GACCGACACCGCTCTAAGAGT	0.637000													10	22					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12383814	12383814	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12383814G>A	ENST00000358136.3	+	35	8097	c.7967G>A	c.(7966-7968)cGc>cAc	p.R2656H	VPS13D_ENST00000356315.4_Missense_Mutation_p.R2656H	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2656	UBA.				protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GATGATTGTCGCAAAGCTCTT	0.388000													33	62					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2752321	2752321	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2752321G>A	ENST00000312371.4	+	7	1674	c.1306G>A	c.(1306-1308)Gcc>Acc	p.A436T	AMZ1_ENST00000407112.1_3'UTR|AMZ1_ENST00000489665.1_Intron	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	436							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		AGCCGTGGACGCCCTCGACCG	0.687000													6	12					0	0	1	0	0
POLR2F	5435	broad.mit.edu	37	22	38352843	38352843	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38352843C>T	ENST00000442738.2	+	2	209	c.84C>T	c.(82-84)gcC>gcT	p.A28A	POLR2F_ENST00000488684.1_Silent_p.A28A|POLR2F_ENST00000606538.1_Silent_p.A28A|POLR2F_ENST00000484894.1_3'UTR|POLR2F_ENST00000470701.1_Silent_p.A23A|POLR2F_ENST00000460648.1_Silent_p.A28A|POLR2F_ENST00000405557.1_Silent_p.A28A|POLR2F_ENST00000407936.1_Silent_p.A28A	NM_021974.3	NP_068809.1	P61218	RPAB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide F	28					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)|urinary_tract(2)	3	Melanoma(58;0.045)					TGGAGAATGCCGAAGAGGTCA	0.483000													19	17					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135428888	135428888	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:135428888C>A	ENST00000394143.1	+	6	3314	c.3023C>A	c.(3022-3024)cCt>cAt	p.P1008H	GPR112_ENST00000370652.1_Missense_Mutation_p.P1008H|GPR112_ENST00000287534.4_Missense_Mutation_p.P945H|GPR112_ENST00000412101.1_Missense_Mutation_p.P803H|GPR112_ENST00000394141.1_Missense_Mutation_p.P803H	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1008					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TCAGCAACCCCTGTGCCTGTT	0.512000													4	70					0.00024832	0.000253518	1	1	0
OR4D1	26689	broad.mit.edu	37	17	56232829	56232829	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56232829C>T	ENST00000268912.5	+	1	336	c.315C>T	c.(313-315)caC>caT	p.H105H		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TCTTCTTCCACCTTTTGGGAG	0.527000													21	28					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129901245	129901245	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:129901245T>C	ENST00000368654.3	-	13	9234	c.8859A>G	c.(8857-8859)ggA>ggG	p.G2953G	MKI67_ENST00000368653.3_Silent_p.G2593G	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2953					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTAGAGGTTTTCCACTGTCAG	0.483000													6	144					0	0	1	0	0
RP11-699L21.1	0	broad.mit.edu	37	3	193711609	193711609	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:193711609C>T	ENST00000397645.2	-	0	75				RP11-699L21.2_ENST00000426616.1_lincRNA	NR_033944.1																						ATGTTTCAGGCGTATCTTGCT	0.453000													3	7					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21174145	21174145	+	Silent	SNP	C	C	T	rs140108411		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:21174145C>T	ENST00000255882.6	-	6	659	c.573G>A	c.(571-573)tcG>tcA	p.S191S	PI4KA_ENST00000572273.1_Silent_p.S133S	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	133					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CAAATGCTCGCGAGATTCCTA	0.433000													7	99					0	0	1	0	0
KRT16P3	0	broad.mit.edu	37	17	20407308	20407308	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:20407308C>T	ENST00000580113.1	-	0	331																											TCCAGGTCGGCGTTGGCCTCC	0.597000													43	83					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47888469	47888469	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47888469T>G	ENST00000446256.2	+	12	2362	c.1790T>G	c.(1789-1791)cTg>cGg	p.L597R	DHX30_ENST00000445061.1_Missense_Mutation_p.L636R|DHX30_ENST00000348968.4_Missense_Mutation_p.L608R|DHX30_ENST00000457607.1_Missense_Mutation_p.L664R	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	636	Helicase ATP-binding.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CACCAGTACCTGCACCGGCAC	0.632000													13	22					0	0	1	0	0
C8G	733	broad.mit.edu	37	9	139841131	139841131	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139841131C>T	ENST00000224181.3	+	6	645	c.585C>T	c.(583-585)caC>caT	p.H195H	C8G_ENST00000465773.1_3'UTR	NM_000606.2	NP_000597.2	P07360	CO8G_HUMAN	complement component 8, gamma polypeptide	195					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex	retinol binding|transporter activity			NS(1)|prostate(1)|skin(1)	3	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.88e-06)|Epithelial(140;0.000107)		ACCAGTTCCACGTCCTGGACG	0.672000													6	13					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	68074057	68074057	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:68074057G>A	ENST00000262210.5	+	20	2566	c.2535G>A	c.(2533-2535)caG>caA	p.Q845Q	CSPP1_ENST00000412460.1_Silent_p.Q500Q|CSPP1_ENST00000521168.1_3'UTR	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	880	Glu-rich.					centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			ACATGAGACAGCCTTCTCCTA	0.363000													8	84					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238048881	238048881	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:238048881C>T	ENST00000366570.4	-	8	1129		c.e8-1		RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4						acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TAGTTTTTATCTGCAAGAGGC	0.458000													15	18					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1053571	1053571	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1053571T>C	ENST00000264930.5	-	23	3096	c.3053A>G	c.(3052-3054)cAc>cGc	p.H1018R		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	1018					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CACAGCCGTGTGCATCCGCCT	0.662000													13	14					0	0	1	0	0
WSCD1	23302	broad.mit.edu	37	17	5993711	5993711	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:5993711G>A	ENST00000574946.1	+	4	1003	c.613G>A	c.(613-615)Gtg>Atg	p.V205M	WSCD1_ENST00000539421.1_Missense_Mutation_p.V205M|WSCD1_ENST00000317744.5_Missense_Mutation_p.V205M|WSCD1_ENST00000574232.1_Missense_Mutation_p.V205M|WSCD1_ENST00000573634.1_Missense_Mutation_p.V89M			Q658N2	WSCD1_HUMAN	WSC domain containing 1	205	WSC 1.					integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						AGCGGTGAGCGTGGGGCTGGA	0.662000													8	73					0	0	1	0	0
PITX2	5308	broad.mit.edu	37	4	111542460	111542460	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:111542460G>A	ENST00000354925.2	-	6	1955	c.250C>T	c.(250-252)Cgg>Tgg	p.R84W	PITX2_ENST00000394598.2_Missense_Mutation_p.R84W|PITX2_ENST00000306732.3_Missense_Mutation_p.R91W|PITX2_ENST00000557119.2_Missense_Mutation_p.R91W|PITX2_ENST00000355080.5_Missense_Mutation_p.R38W|PITX2_ENST00000394595.3_Intron	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	84					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CGCCTTTGCCGCTTCTTCTTA	0.567000													28	38					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	32981637	32981637	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:32981637A>G	ENST00000374864.4	+	3	233	c.20A>G	c.(19-21)cAa>cGa	p.Q7R	ITCH_ENST00000535650.1_5'UTR|ITCH_ENST00000262650.6_Missense_Mutation_p.Q7R	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	7	C2.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						AGTGGATCACAACTTGGTTCA	0.378000													50	99					0	0	1	0	0
OSR2	116039	broad.mit.edu	37	8	99961724	99961724	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:99961724A>G	ENST00000297565.4	+	2	1040	c.544A>G	c.(544-546)Acc>Gcc	p.T182A	OSR2_ENST00000522510.1_Missense_Mutation_p.T182A|OSR2_ENST00000523368.1_Missense_Mutation_p.T182A|OSR2_ENST00000457907.2_Missense_Mutation_p.T303A|OSR2_ENST00000435298.2_Missense_Mutation_p.T182A	NM_001142462.1	NP_001135934.1	Q8N2R0	OSR2_HUMAN	odd-skipped related transciption factor 2	182					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			CAGACACTTTACCAAATCCTA	0.512000													48	68					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152364588	152364588	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:152364588C>T	ENST00000427231.2	-	162	23584	c.23382G>A	c.(23380-23382)tcG>tcA	p.S7794S	NEB_ENST00000172853.10_Silent_p.S6093S|NEB_ENST00000409198.1_Silent_p.S6093S|NEB_ENST00000604864.1_Silent_p.S7794S|NEB_ENST00000603639.1_Silent_p.S7794S|NEB_ENST00000397345.3_Silent_p.S7794S	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	6093					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCTCATAATACGACATGGACT	0.428000													13	13					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19747821	19747821	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19747821C>A	ENST00000203556.4	-	12	1279	c.1142G>T	c.(1141-1143)aGa>aTa	p.R381I	GMIP_ENST00000587238.1_Missense_Mutation_p.R381I|GMIP_ENST00000445806.2_Missense_Mutation_p.R381I	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	381	Pro-rich.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GAGCTTCTTTCTGATGTCCAG	0.567000													4	3					0.00909568	0.00918626	1	1	0
SVIP	258010	broad.mit.edu	37	11	22849398	22849398	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:22849398G>A	ENST00000354193.4	-	2	193	c.77C>T	c.(76-78)gCa>gTa	p.A26V	SVIP_ENST00000533774.1_5'UTR	NM_148893.1	NP_683691.1	Q8NHG7	SVIP_HUMAN	small VCP/p97-interacting protein	26						Golgi membrane|plasma membrane|smooth endoplasmic reticulum membrane				cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	3						TGCAGCCTCTGCAAGCTTTGC	0.284000													9	20					0	0	1	0	0
PCDHA4	0	broad.mit.edu	37	5	140187880	140187880	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140187880G>A	ENST00000530339.1	+	1	1108	c.1108G>A	c.(1108-1110)Gcc>Acc	p.A370T	PCDHA4_ENST00000512229.2_Missense_Mutation_p.A370T|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.A370T|PCDHA2_ENST00000526136.1_Intron	NM_018907.2	NP_061730.1												p.A370S(2)		breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACAGTCATCGCCCTGATCAG	0.493000													20	42					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112740448	112740448	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:112740448G>A	ENST00000295408.4	+	8	1431	c.1174G>A	c.(1174-1176)Gtg>Atg	p.V392M	MERTK_ENST00000421804.2_Missense_Mutation_p.V392M|MERTK_ENST00000409780.1_Missense_Mutation_p.V216M			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	392	Fibronectin type-III 2.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						AAATGTCACTGTGTTTCTGAA	0.438000													14	88					0	0	1	0	0
RPH3AL	9501	broad.mit.edu	37	17	97005	97005	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:97005G>A	ENST00000323434.8	-	6	1020	c.423C>T	c.(421-423)ggC>ggT	p.G141G	RPH3AL_ENST00000536489.2_Silent_p.G141G|RPH3AL_ENST00000576001.1_5'UTR|RPH3AL_ENST00000331302.7_Silent_p.G170G	NM_001190412.1	NP_001177341.1	Q9UNE2	RPH3L_HUMAN	rabphilin 3A-like (without C2 domains)	170	RabBD.				exocytosis|intracellular protein transport	transport vesicle membrane	cytoskeletal protein binding|Rab GTPase binding|zinc ion binding			NS(2)|breast(1)|kidney(1)|large_intestine(1)|skin(1)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.023)|all cancers(1;4.96e-06)|Epithelial(1;2.86e-05)|BRCA - Breast invasive adenocarcinoma(1;0.00453)|OV - Ovarian serous cystadenocarcinoma(1;0.0716)|LUAD - Lung adenocarcinoma(1115;0.102)|COAD - Colon adenocarcinoma(4;0.107)		CATCAGCTCGGCCAGGGGTCT	0.627000													3	17					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55579030	55579030	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55579030C>A	ENST00000333973.2	+	1	177	c.88C>A	c.(88-90)Ctg>Atg	p.L30M		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				CCTCTTCCTGCTGTTCCTTCT	0.493000													6	139					0.00307968	0.00311927	1	1	0
HOMER1	9456	broad.mit.edu	37	5	78746842	78746842	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:78746842C>T	ENST00000334082.6	-	3	1707	c.265G>A	c.(265-267)Gga>Aga	p.G89R	HOMER1_ENST00000282260.6_Missense_Mutation_p.G89R|HOMER1_ENST00000535690.1_Intron|HOMER1_ENST00000508576.1_Missense_Mutation_p.G89R	NM_004272.3	NP_004263.1	Q86YM7	HOME1_HUMAN	homer homolog 1 (Drosophila)	89	WH1.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|skin(1)	14		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		GAGGAGAATCCCAATCCATAA	0.348000													19	27					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37136300	37136300	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:37136300C>T	ENST00000310758.4	-	15	1871	c.1224G>A	c.(1222-1224)aaG>aaA	p.K408K	ELMO1_ENST00000448602.1_Silent_p.K408K|ELMO1_ENST00000341056.3_Silent_p.K110K|ELMO1_ENST00000442504.1_Silent_p.K408K	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	408	ELMO.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						GACATTCATGCTTGTCTTCTC	0.413000													33	58					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96058386	96058386	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:96058386C>T	ENST00000260766.3	+	24	6052	c.5418C>T	c.(5416-5418)ctC>ctT	p.L1806L	PLCE1_ENST00000371375.1_Silent_p.L1498L|PLCE1_ENST00000371385.3_Silent_p.L1498L|PLCE1_ENST00000371380.2_Silent_p.L1806L	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1806	PI-PLC Y-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				TGTTCTGGCTCCATGGGATAC	0.537000													32	37					0	0	1	0	0
STAT5B	6777	broad.mit.edu	37	17	40362188	40362188	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40362188C>T	ENST00000293328.3	-	15	2075		c.e15+1			NM_012448.3	NP_036580.2	P51692	STA5B_HUMAN	signal transducer and activator of transcription 5B						2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GGGGCACTCACGAGAATCAAA	0.418000													14	21					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105179320	105179320	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105179320C>T	ENST00000392634.4	+	18	2878	c.2766C>T	c.(2764-2766)cgC>cgT	p.R922R	INF2_ENST00000330634.7_Silent_p.R922R	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	922	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		TTTTCCTCCGCGCCCTGAAGG	0.667000													38	74					0	0	1	0	0
KCNA2	3737	broad.mit.edu	37	1	111147039	111147039	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:111147039C>T	ENST00000485317.1	-	3	1039	c.366G>A	c.(364-366)gcG>gcA	p.A122A	KCNA2_ENST00000525120.1_Intron|KCNA2_ENST00000316361.4_Silent_p.A122A|KCNA2_ENST00000440270.1_Silent_p.A122A|KCNA2_ENST00000369770.3_Silent_p.A122A			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	122						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		ACATCTCCATCGCTTCTTCTC	0.468000													16	29					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7780603	7780603	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:7780603G>A	ENST00000420658.1	-	14	2055	c.1782_splice	c.e14-1	p.L595_splice	AFAP1_ENST00000513842.1_5'UTR|AFAP1_ENST00000382543.3_Splice_Site_p.L595_splice|AFAP1_ENST00000358461.2_Splice_Site_p.L511_splice|AFAP1_ENST00000360265.4_Splice_Site_p.L511_splice	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	553	Interaction with F-actin (By similarity).					actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						TTACCCTTGAGCTGTTGAAAT	0.408000													10	44					0	0	1	0	0
SOWAHA	134548	broad.mit.edu	37	5	132150756	132150756	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:132150756C>T	ENST00000378693.2	+	1	1724	c.1443C>T	c.(1441-1443)ggC>ggT	p.G481G		NM_175873.4	NP_787069.3	Q2M3V2	ANR43_HUMAN	sosondowah ankyrin repeat domain family member A	481																	CATTTCTGGGCGTCCTGGCTG	0.627000													7	5					0	0	1	0	0
MCMDC2	157777	broad.mit.edu	37	8	67803125	67803125	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:67803125G>A	ENST00000422365.2	+	10	1270	c.1099G>A	c.(1099-1101)Gtc>Atc	p.V367I	MCMDC2_ENST00000396592.3_Missense_Mutation_p.V367I|MCMDC2_ENST00000541540.1_Missense_Mutation_p.V304I|MCMDC2_ENST00000313616.5_Missense_Mutation_p.V367I	NM_173518.4	NP_775789.3	Q4G0Z9	CH045_HUMAN	minichromosome maintenance domain containing 2	367					DNA replication		ATP binding|DNA binding			endometrium(2)|kidney(2)|lung(5)	9						CATAAACCTTGTCCCCCGTGG	0.338000													18	80					0	0	1	0	0
MLPH	79083	broad.mit.edu	37	2	238419298	238419298	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:238419298C>T	ENST00000264605.3	+	3	486	c.192C>T	c.(190-192)tgC>tgT	p.C64C	MLPH_ENST00000468178.1_3'UTR|MLPH_ENST00000445024.2_Silent_p.C64C|MLPH_ENST00000338530.4_Silent_p.C64C|MLPH_ENST00000410032.1_Silent_p.C64C|MLPH_ENST00000409373.1_Silent_p.C64C	NM_024101.5	NP_077006.1	Q9BV36	MELPH_HUMAN	melanophilin	64	RabBD.						metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(3)|large_intestine(2)|lung(11)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	25		Breast(86;0.000381)|Renal(207;0.000966)|Ovarian(221;0.0695)|all_hematologic(139;0.095)|all_lung(227;0.17)|Melanoma(123;0.203)		Epithelial(121;1.17e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.02e-10)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.15e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000439)|Lung(119;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0316)		AGACCCACTGCGCCCGCTGCC	0.562000													5	18					0	0	1	0	0
KRBA2	124751	broad.mit.edu	37	17	8273384	8273384	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8273384G>A	ENST00000396267.1	-	2	1132	c.301C>T	c.(301-303)Cga>Tga	p.R101*	RP11-849F2.5_ENST00000583963.1_RNA|RP11-849F2.7_ENST00000582471.1_3'UTR|RP11-849F2.5_ENST00000580537.1_RNA|KRBA2_ENST00000331336.2_Nonsense_Mutation_p.R183*			Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	183	KRAB.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding	p.R183*(1)		endometrium(2)|kidney(2)|large_intestine(7)|lung(5)|stomach(1)|urinary_tract(1)	18						TACCGTATTCGATCACGTTCT	0.438000													20	129					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128627966	128627966	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:128627966C>T	ENST00000335251.5	+	12	2216	c.2113C>T	c.(2113-2115)Cgc>Tgc	p.R705C		NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	705										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						CTTAAAGACACGCAAGCCTAG	0.473000													35	49					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130877827	130877827	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:130877827C>T	ENST00000357462.5	-	1	355	c.262G>A	c.(262-264)Gac>Aac	p.D88N	POTEF_ENST00000361163.4_Missense_Mutation_p.D88N|POTEF_ENST00000409914.2_Missense_Mutation_p.D88N|POTEF_ENST00000360967.5_Missense_Mutation_p.D88N			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	88						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						ATAGCAGAGTCGTCGTGGTCT	0.617000													67	165					0	0	1	0	0
ITFG1	81533	broad.mit.edu	37	16	47488059	47488059	+	Missense_Mutation	SNP	C	C	T	rs148994423	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:47488059C>T	ENST00000320640.6	-	3	520	c.292G>A	c.(292-294)Gca>Aca	p.A98T	ITFG1_ENST00000544001.2_5'UTR	NM_030790.3	NP_110417.2	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	98						extracellular region|integral to membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	19		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				GTTATCAATGCACTGTGATTC	0.343000													46	86					0	0	1	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27827122	27827122	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:27827122G>T	ENST00000396319.2	+	8	1026	c.938G>T	c.(937-939)aGc>aTc	p.S313I	TAX1BP1_ENST00000543117.1_Missense_Mutation_p.S313I|TAX1BP1_ENST00000409980.1_Missense_Mutation_p.S313I|TAX1BP1_ENST00000265393.6_Missense_Mutation_p.S313I|TAX1BP1_ENST00000433216.2_Missense_Mutation_p.S156I	NM_006024.6	NP_006015.4	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I) binding protein 1	313					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(8)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31			GBM - Glioblastoma multiforme(3;0.0823)			AACAAAGAAAGCGTGATTACT	0.358000													29	32					5.77227e-19	6.37883e-19	1	1	0
GRSF1	2926	broad.mit.edu	37	4	71693681	71693681	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:71693681G>A	ENST00000254799.6	-	6	1140	c.1023C>T	c.(1021-1023)atC>atT	p.I341I	GRSF1_ENST00000508091.1_Intron|GRSF1_ENST00000502323.1_Silent_p.I179I|GRSF1_ENST00000439371.1_Silent_p.I179I|GRSF1_ENST00000545193.1_Silent_p.I223I	NM_002092.3	NP_002083.3	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1	341					mRNA polyadenylation		mRNA binding|nucleotide binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(2)	17		all_hematologic(202;0.21)	Lung(101;0.235)			GAAAAGATGCGATTTTCTTTC	0.373000													4	76					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52475658	52475658	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52475658G>T	ENST00000231721.2	-	6	598	c.599C>A	c.(598-600)gCc>gAc	p.A200D		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	200	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		GAAGATCATGGCCTCTCGCCC	0.652000													14	11					4.3838e-07	4.58243e-07	1	1	0
RBM42	79171	broad.mit.edu	37	19	36122298	36122298	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36122298C>T	ENST00000262633.4	+	4	538	c.433C>T	c.(433-435)Cgg>Tgg	p.R145W	RBM42_ENST00000586618.1_Intron|RBM42_ENST00000360475.4_Missense_Mutation_p.R145W|RBM42_ENST00000589871.1_Missense_Mutation_p.R145W|RBM42_ENST00000588161.1_Missense_Mutation_p.R145W|RBM42_ENST00000592202.1_Intron|RBM42_ENST00000589559.1_Missense_Mutation_p.R145W	NM_024321.3	NP_077297.2	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	145						cytoplasm|nucleus	nucleotide binding|RNA binding	p.R145W(1)		breast(1)|endometrium(3)|large_intestine(7)|lung(9)|prostate(1)	21	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CATGTTCCTGCGGCGGGCAGG	0.567000													26	28					0	0	1	0	0
POGZ	23126	broad.mit.edu	37	1	151396574	151396574	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151396574G>A	ENST00000271715.2	-	9	1688	c.1374C>T	c.(1372-1374)ggC>ggT	p.G458G	POGZ_ENST00000368863.2_Silent_p.G363G|POGZ_ENST00000361398.3_Silent_p.G405G|POGZ_ENST00000392723.1_Silent_p.G405G|POGZ_ENST00000409503.1_Silent_p.G449G|POGZ_ENST00000540984.1_Intron|POGZ_ENST00000491586.1_Silent_p.G405G|POGZ_ENST00000531094.1_Silent_p.G396G	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	458					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGACGGCATCGCCCACGTTCT	0.507000													27	51					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19822634	19822634	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19822634G>A	ENST00000344099.3	-	4	1594	c.1456C>T	c.(1456-1458)Cgt>Tgt	p.R486C		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	486					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				GAACTGGAACGAATGAAAACT	0.403000													5	93					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71155238	71155238	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:71155238G>A	ENST00000355527.3	-	4	398	c.122C>T	c.(121-123)gCg>gTg	p.A41V	DHCR7_ENST00000407721.2_Missense_Mutation_p.A41V	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	41					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	GATGACGCTCGCCAGTGAAAA	0.607000									Smith-Lemli-Opitz syndrome				4	4					0	0	1	0	0
DYRK4	8798	broad.mit.edu	37	12	4700381	4700381	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:4700381C>A	ENST00000540757.2	+	3	195	c.35C>A	c.(34-36)cCt>cAt	p.P12H	DYRK4_ENST00000543431.1_Missense_Mutation_p.P12H|DYRK4_ENST00000010132.5_Missense_Mutation_p.P12H	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	12						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			TCAGAAATACCTTTCCACCCT	0.483000													16	32					2.23348e-06	2.32236e-06	1	1	0
ISG20L2	81875	broad.mit.edu	37	1	156693974	156693974	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156693974T>C	ENST00000313146.6	-	2	1696	c.914A>G	c.(913-915)cAt>cGt	p.H305R	ISG20L2_ENST00000472824.1_5'UTR|ISG20L2_ENST00000368219.1_Missense_Mutation_p.H305R	NM_030980.1	NP_112242.1	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene 20kDa-like 2	305	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTTGGTGAGATGCTTCAGAGA	0.587000													13	57					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106960748	106960748	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:106960748C>T	ENST00000369066.3	+	1	1019	c.532C>T	c.(532-534)Cac>Tac	p.H178Y		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	178							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CAAGCCCGAGCACAAGAGGGG	0.716000													3	3					0	0	1	0	0
OTOS	150677	broad.mit.edu	37	2	241078658	241078658	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:241078658C>T	ENST00000391989.2	-	5	429	c.199G>A	c.(199-201)Gcc>Acc	p.A67T	OTOS_ENST00000319460.1_Missense_Mutation_p.A67T			Q8NHW6	OTOSP_HUMAN	otospiralin	67						extracellular region				endometrium(2)|large_intestine(1)|lung(3)	6		all_epithelial(40;2.79e-15)|Breast(86;3.04e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|Hepatocellular(293;0.148)|all_hematologic(139;0.158)|Melanoma(123;0.16)		Epithelial(32;2.56e-30)|all cancers(36;7.18e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.37e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.07e-06)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		AAGGTTCGGGCCATGTCCTCG	0.637000													16	28					0	0	1	0	0
POLD2	5425	broad.mit.edu	37	7	44154942	44154942	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44154942C>T	ENST00000406581.2	-	11	1850	c.1201G>A	c.(1201-1203)Gtc>Atc	p.V401I	POLD2_ENST00000223361.3_Missense_Mutation_p.V387I|POLD2_ENST00000452185.1_Missense_Mutation_p.V401I	NM_001256879.1	NP_001243808.1	P49005	DPOD2_HUMAN	polymerase (DNA directed), delta 2, accessory subunit	401					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	12						CAAAAGTAGACATGCGGGCAC	0.532000													8	56					0	0	1	0	0
SLC38A11	151258	broad.mit.edu	37	2	165771691	165771691	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:165771691C>T	ENST00000303735.4	-	7	877	c.547G>A	c.(547-549)Gtg>Atg	p.V183M	SLC38A11_ENST00000409662.1_Missense_Mutation_p.V205M|SLC38A11_ENST00000409149.3_Missense_Mutation_p.V205M|SLC38A11_ENST00000409058.1_Missense_Mutation_p.V236M|SLC38A11_ENST00000493887.1_5'UTR	NM_173512.2	NP_775783.1	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	205					amino acid transport|sodium ion transport	integral to membrane		p.V183M(1)		endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15						ACAGAAATCACGATGGACATA	0.378000													14	46					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56641924	56641924	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56641924C>T	ENST00000267116.7	-	18	1982	c.1861G>A	c.(1861-1863)Gca>Aca	p.A621T		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	621							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						AGGAAGAGTGCGGTCCGGCCC	0.632000													20	34					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16892269	16892269	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16892269G>A	ENST00000430580.2	-	27	3810	c.2923C>T	c.(2923-2925)Cct>Tct	p.P975S		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	975	NBPF 6.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AAGACTTCAGGCTCTACTGCC	0.488000													26	1306					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128478072	128478072	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128478072G>A	ENST00000325888.8	+	6	1262	c.1001G>A	c.(1000-1002)cGc>cAc	p.R334H	FLNC_ENST00000346177.6_Missense_Mutation_p.R334H	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	334					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GACAAGGATCGCACCTATGCT	0.542000													28	46					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79378293	79378293	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:79378293C>T	ENST00000350881.2	+	21	2939	c.2749C>T	c.(2749-2751)Cgt>Tgt	p.R917C	CTD-2201I18.1_ENST00000514042.1_RNA|THBS4_ENST00000504720.1_3'UTR|THBS4_ENST00000511733.1_Missense_Mutation_p.R826C	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	917	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		CACCACAATGCGTGGAGGCCG	0.512000													14	62					0	0	1	0	0
CHRNB1	1140	broad.mit.edu	37	17	7359976	7359976	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7359976C>T	ENST00000306071.2	+	11	1507	c.1440C>T	c.(1438-1440)agC>agT	p.S480S	CHRNB1_ENST00000536404.2_Silent_p.S408S|CHRNB1_ENST00000576360.1_Silent_p.S359S|CHRNB1_ENST00000575379.1_Silent_p.S16S	NM_000747.2	NP_000738.2	P11230	ACHB_HUMAN	cholinergic receptor, nicotinic, beta 1 (muscle)	480					behavioral response to nicotine|muscle contraction|muscle fiber development|neuromuscular synaptic transmission|postsynaptic membrane organization|regulation of membrane potential|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine binding|receptor activity			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|ovary(3)	23		Prostate(122;0.157)				TCTTCACCAGCGTTGGGACCC	0.577000													29	34					0	0	1	0	0
TTC9C	283237	broad.mit.edu	37	11	62505762	62505762	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62505762G>A	ENST00000316461.4	+	3	734	c.424G>A	c.(424-426)Gcc>Acc	p.A142T	TTC9C_ENST00000532583.1_Missense_Mutation_p.A142T	NM_173810.3	NP_776171.1	Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	142							binding			breast(1)|endometrium(1)|lung(2)|ovary(1)|pancreas(1)	6						CTTCCAAGATGCCAACGTCCG	0.448000													8	17					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18533607	18533607	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:18533607C>T	ENST00000399799.1	-	32	4933	c.3993G>A	c.(3991-3993)acG>acA	p.T1331T		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	1331	Auto-inhibitory.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					TTGTAGAAAGCGTTCGAGGGG	0.373000													68	87					0	0	1	0	0
KHSRP	8570	broad.mit.edu	37	19	6415312	6415312	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6415312G>A	ENST00000398148.3	-	19	2059	c.1966_splice	c.e19-1	p.A656_splice		NM_003685.2	NP_003676.2	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	656	4 X 12 AA imperfect repeats.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|liver(1)|lung(6)|skin(1)|soft_tissue(1)	17						GGCCACTTGCGCTGTGGGTGG	0.642000													9	25					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144070324	144070324	+	Nonsense_Mutation	SNP	C	C	T	rs150657398	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:144070324C>T	ENST00000056217.5	+	10	4261	c.4087C>T	c.(4087-4089)Cga>Tga	p.R1363*	ARHGEF5_ENST00000471847.2_Nonsense_Mutation_p.R285*	NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	1363					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					CCAGAGTATGCGACGGACAGA	0.522000													28	56					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109182100	109182100	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:109182100G>A	ENST00000326495.5	-	15	2907	c.2814C>T	c.(2812-2814)agC>agT	p.S938S	SSH1_ENST00000360239.3_Silent_p.S626S	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	938	Interaction with YWHAG.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GGATGCTATCGCTGCTGGAGC	0.602000													31	37					0	0	1	0	0
AIFM2	84883	broad.mit.edu	37	10	71874699	71874699	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:71874699C>T	ENST00000307864.1	-	8	1160	c.947G>A	c.(946-948)cGg>cAg	p.R316Q	AIFM2_ENST00000373248.1_Missense_Mutation_p.R316Q|AIFM2_ENST00000482166.1_5'UTR	NM_001198696.1|NM_032797.5	NP_001185625.1|NP_116186.1	Q9BRQ8	AIFM2_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 2	316					apoptotic mitochondrial changes|chromosome condensation|induction of apoptosis	cytosol|integral to membrane|mitochondrial outer membrane	DNA binding|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|urinary_tract(2)	16						CTGGAGAGGCCGCTGCTTCAC	0.562000													5	15					0	0	1	0	0
DNM1L	10059	broad.mit.edu	37	12	32886741	32886741	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:32886741G>A	ENST00000452533.2	+	13	1703	c.1539_splice	c.e13+1	p.E513_splice	YARS2_ENST00000551673.1_Intron|DNM1L_ENST00000549701.1_Splice_Site_p.E513_splice|DNM1L_ENST00000553257.1_Splice_Site_p.E526_splice|DNM1L_ENST00000547312.1_Splice_Site_p.E513_splice|DNM1L_ENST00000381000.4_Splice_Site_p.E526_splice|DNM1L_ENST00000414834.2_Splice_Site_p.E310_splice|DNM1L_ENST00000358214.5_Splice_Site_p.E526_splice|DNM1L_ENST00000266481.6_Splice_Site_p.E513_splice	NM_012062.3|NM_012063.2	NP_036192.2|NP_036193.2	O00429	DNM1L_HUMAN	dynamin 1-like	513	B domain.|Interaction with GSK3B.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	23	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					ATAATATAGAGGTAAATATAA	0.313000													52	62					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15820787	15820787	+	Missense_Mutation	SNP	G	G	A	rs138623948		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:15820787G>A	ENST00000338282.6	-	28	3882	c.3776C>T	c.(3775-3777)gCg>gTg	p.A1259V	MYH11_ENST00000576790.1_Missense_Mutation_p.A1259V|AF001548.5_ENST00000574212.1_RNA|MYH11_ENST00000452625.2_Missense_Mutation_p.A1266V|MYH11_ENST00000396324.3_Missense_Mutation_p.A1266V|MYH11_ENST00000300036.5_Missense_Mutation_p.A1259V	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1259			Missing (in AAT4).		axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CTGCACCTGCGCCTCCAGCTT	0.637000			T	CBFB	AML								59	86					0	0	1	0	0
ACCS	84680	broad.mit.edu	37	11	44097102	44097102	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:44097102G>A	ENST00000432284.2	+	5	822	c.445G>A	c.(445-447)Gct>Act	p.A149T	ACCS_ENST00000263776.8_Silent_p.S172S|ACCS_ENST00000533208.1_3'UTR			Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)	347							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(4)|endometrium(3)|large_intestine(11)|lung(15)|ovary(1)|skin(1)	35						GTGGTGCCTCGCTCTTCTCTG	0.607000													22	20					0	0	1	0	0
SIK2	23235	broad.mit.edu	37	11	111571640	111571640	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:111571640G>A	ENST00000304987.3	+	5	682	c.509G>A	c.(508-510)gGt>gAt	p.G170D		NM_015191.1	NP_056006.1	Q9H0K1	SIK2_HUMAN	salt-inducible kinase 2	170	Protein kinase.				intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	30						TTTAAAAGTGGTGAACTGCTG	0.418000													23	38					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111786040	111786040	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:111786040C>T	ENST00000261726.6	+	22	4526	c.4372C>T	c.(4372-4374)Cgg>Tgg	p.R1458W		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1458						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CTTGCAGCGGCGGCATGAGAA	0.617000													38	46					0	0	1	0	0
ARHGAP18	93663	broad.mit.edu	37	6	129899715	129899715	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:129899715C>A	ENST00000368149.2	-	15	2023	c.1935G>T	c.(1933-1935)aaG>aaT	p.K645N	ARHGAP18_ENST00000463225.1_5'UTR	NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	645					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		GATATAAATCCTTCATGTAAG	0.373000													38	54					4.17593e-13	4.53019e-13	1	1	0
VWA8	23078	broad.mit.edu	37	13	42185773	42185773	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:42185773C>T	ENST00000379310.3	-	39	4884	c.4816G>A	c.(4816-4818)Gca>Aca	p.A1606T		NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		TCGGGAACTGCATCTTTCTCA	0.572000													29	38					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30888485	30888485	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:30888485G>A	ENST00000392772.2	-	8	755	c.478C>T	c.(478-480)Cgc>Tgc	p.R160C	RP4-539M6.14_ENST00000442126.1_RNA|SEC14L4_ENST00000540456.1_Missense_Mutation_p.R199C|SEC14L4_ENST00000381982.3_Missense_Mutation_p.R214C|SEC14L4_ENST00000255858.7_Missense_Mutation_p.R214C			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	214	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	ATCTTCCTGCGTGTCTCCTCA	0.527000													18	19					0	0	1	0	0
LYL1	4066	broad.mit.edu	37	19	13211556	13211556	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13211556G>A	ENST00000264824.4	-	3	702	c.342C>T	c.(340-342)taC>taT	p.Y114Y		NM_005583.4	NP_005574.2	P12980	LYL1_HUMAN	lymphoblastic leukemia derived sequence 1	114					B cell differentiation|blood vessel maturation|definitive hemopoiesis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			cervix(1)|endometrium(2)|kidney(1)|lung(2)|prostate(1)	7			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)			CTGGCCCAATGTAGACACTGT	0.602000			T	TRB@	T-ALL								30	26					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45427310	45427310	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:45427310G>A	ENST00000321429.4	+	6	723	c.316G>A	c.(316-318)Gtg>Atg	p.V106M	DUOX1_ENST00000389037.3_Missense_Mutation_p.V106M	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	106	Peroxidase-like; mediates peroxidase activity.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity	p.V106L(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		AGGCTATCACGTGCTTTCAGA	0.622000													11	24					0	0	1	0	0
CTNNAL1	8727	broad.mit.edu	37	9	111754918	111754918	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:111754918T>C	ENST00000374595.4	-	3	592	c.513A>G	c.(511-513)agA>agG	p.R171R	CTNNAL1_ENST00000325580.6_Silent_p.R171R|CTNNAL1_ENST00000374593.4_Silent_p.R171R|CTNNAL1_ENST00000325551.4_Silent_p.R171R			Q9UBT7	CTNL1_HUMAN	catenin (cadherin-associated protein), alpha-like 1	171					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(4)|urinary_tract(2)	25				STAD - Stomach adenocarcinoma(157;0.0768)		GTACCTTATTTCTTGATGTTA	0.373000													3	35					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18300494	18300494	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:18300494G>A	ENST00000441493.2	-	26	5285	c.4933C>T	c.(4933-4935)Cgc>Tgc	p.R1645C		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1645						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		TCAGGCCGGCGCTCCTTGCCC	0.711000													8	14					0	0	1	0	0
SOX6	55553	broad.mit.edu	37	11	16010577	16010577	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:16010577G>A	ENST00000352083.6	-	14	2009	c.1932C>T	c.(1930-1932)ccC>ccT	p.P644P	SOX6_ENST00000396356.3_Silent_p.P624P|SOX6_ENST00000316399.6_Silent_p.P624P|SOX6_ENST00000527619.1_Silent_p.P620P|SOX6_ENST00000528252.1_Silent_p.P617P|SOX6_ENST00000528429.1_Silent_p.P644P			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	644					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity	p.P624P(1)|p.P620P(1)		NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						TATGCATGTCGGGGAAGGCCT	0.522000											OREG0020800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	68	90					0	0	1	0	0
IDI2	91734	broad.mit.edu	37	10	1068717	1068717	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:1068717T>C	ENST00000277517.1	-	3	207		c.e3-2		IDI2-AS1_ENST00000420381.1_RNA|IDI2-AS1_ENST00000437374.1_RNA|IDI2-AS1_ENST00000434470.1_RNA|IDI2-AS1_ENST00000428780.2_RNA|IDI2-AS1_ENST00000536039.1_RNA	NM_033261.2	NP_150286.1	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2						carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	9		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		GCAGCAGCCCTGCAAAGGTAA	0.493000													11	29					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37771287	37771287	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37771287G>A	ENST00000402918.1	-	3	1073	c.288C>T	c.(286-288)gaC>gaT	p.D96D	ELFN2_ENST00000349653.3_Silent_p.D96D|RP1-63G5.5_ENST00000430883.1_RNA	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	96						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					GGAAGGCACCGTCCTCGATGT	0.602000													14	27					0	0	1	0	0
TRIM27	5987	broad.mit.edu	37	6	28891196	28891196	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:28891196C>T	ENST00000377199.3	-	1	570	c.214G>A	c.(214-216)Gcc>Acc	p.A72T	TRIM27_ENST00000377194.3_Missense_Mutation_p.A72T	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	72					cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						GTCACGTTGGCCAGGTGCCGG	0.706000			T	RET	papillary thyroid								8	14					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27414082	27414082	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27414082G>A	ENST00000527372.1	-	38	5764	c.5584C>T	c.(5584-5586)Cgc>Tgc	p.R1862C	TIAF1_ENST00000408971.2_5'UTR|MYO18A_ENST00000354329.4_Missense_Mutation_p.R1862C|MYO18A_ENST00000529578.1_5'UTR|MYO18A_ENST00000533112.1_Missense_Mutation_p.R1825C|MYO18A_ENST00000531253.1_Missense_Mutation_p.R1862C	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	1862					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GCTGCAATGCGCTGATCCCGC	0.597000													4	86					0	0	1	0	0
ZFR	51663	broad.mit.edu	37	5	32397417	32397417	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:32397417G>A	ENST00000265069.8	-	10	1843	c.1741C>T	c.(1741-1743)Cgg>Tgg	p.R581W		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	581					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		CAATGGAACCGAATTACTTTT	0.343000													30	49					0	0	1	0	0
AMBP	259	broad.mit.edu	37	9	116835296	116835296	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:116835296C>T	ENST00000265132.3	-	5	727	c.465G>A	c.(463-465)ccG>ccA	p.P155P		NM_001633.3	NP_001624.1	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin precursor	155					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	11					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	CCCTCAGCTGCGGCGCCCGCC	0.572000													7	8					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26603704	26603704	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26603704C>T	ENST00000252992.4	+	14	2340	c.2209C>T	c.(2209-2211)Cgt>Tgt	p.R737C	CEP85_ENST00000469609.1_3'UTR|CEP85_ENST00000451429.2_Missense_Mutation_p.R686C	NM_022778.2	NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	737						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						TCAACAGCTGCGTCGTGACAT	0.502000													42	63					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31168721	31168721	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:31168721C>T	ENST00000349752.5	-	7	1309	c.670G>A	c.(670-672)Gtg>Atg	p.V224M	GALNT14_ENST00000486564.1_5'UTR|GALNT14_ENST00000356174.3_Missense_Mutation_p.V191M|GALNT14_ENST00000420311.2_Missense_Mutation_p.V189M|GALNT14_ENST00000324589.5_Missense_Mutation_p.V229M|GALNT14_ENST00000406653.1_Missense_Mutation_p.V204M	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	224						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					ACAGGGCACACCACCCGCGTG	0.582000													5	43					0	0	1	0	0
UFL1	23376	broad.mit.edu	37	6	96988479	96988479	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:96988479C>T	ENST00000369278.4	+	11	1293	c.1227C>T	c.(1225-1227)agC>agT	p.S409S		NM_015323.4	NP_056138.1	O94874	UFL1_HUMAN	UFM1-specific ligase 1	409					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity										CTTTAGAAAGCGTTAGTACAA	0.299000													12	22					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153864466	153864466	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:153864466A>G	ENST00000511601.1	+	2	445	c.257A>G	c.(256-258)aAc>aGc	p.N86S	FHDC1_ENST00000260008.3_Missense_Mutation_p.N86S			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	86					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					ACTCACATGAACGGCTACAGC	0.557000													22	40					0	0	1	0	0
NRROS	375387	broad.mit.edu	37	3	196386840	196386840	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:196386840G>T	ENST00000328557.4	+	3	529	c.326G>T	c.(325-327)aGc>aTc	p.S109I		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		CACCTGCGCAGCCTGGTCCTG	0.667000													8	9					1.06961e-07	1.12439e-07	1	1	0
BMPR1A	657	broad.mit.edu	37	10	88677048	88677048	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:88677048A>G	ENST00000372037.2	+	9	1370	c.833A>G	c.(832-834)tAc>tGc	p.Y278C		NM_004329.2	NP_004320.2	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA	278	Protein kinase.				BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|skin(1)|stomach(1)	24						ACAGAAATCTACCAAACTGTG	0.443000			"""Mis, N, F"""			gastrointestinal polyps			Juvenile Polyposis;Hereditary Mixed Polyposis syndrome type 2				5	19					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19959484	19959484	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19959484G>T	ENST00000263207.3	-	18	2997	c.2706C>A	c.(2704-2706)tcC>tcA	p.S902S	ARVCF_ENST00000344269.3_Silent_p.S839S|ARVCF_ENST00000406522.1_Silent_p.S833S|ARVCF_ENST00000406259.1_Silent_p.S896S|ARVCF_ENST00000401994.1_Silent_p.S839S	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	902					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					GGTCCACCGTGGAGTATCCGT	0.632000													9	19					2.80697e-09	2.97546e-09	1	1	0
WDR12	55759	broad.mit.edu	37	2	203760881	203760881	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:203760881C>T	ENST00000261015.3	-	6	1265	c.516G>A	c.(514-516)tgG>tgA	p.W172*		NM_018256.3	NP_060726.3	Q9GZL7	WDR12_HUMAN	WD repeat domain 12	172	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding			endometrium(3)|large_intestine(1)|liver(1)|lung(6)|prostate(1)|skin(1)	13						TCTCTACATTCCACTCCCATA	0.393000													26	32					0	0	1	0	0
B4GALT3	8703	broad.mit.edu	37	1	161141751	161141751	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161141751G>T	ENST00000319769.5	-	8	1259	c.1037C>A	c.(1036-1038)cCt>cAt	p.P346H	PPOX_ENST00000535223.1_Intron|PPOX_ENST00000432542.2_Intron|B4GALT3_ENST00000367998.1_Missense_Mutation_p.P346H|B4GALT3_ENST00000470882.1_5'UTR|PPOX_ENST00000495483.1_Intron	NM_001199873.1|NM_003779.3	NP_001186802.1|NP_003770.1	O60512	B4GT3_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	346					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|metal ion binding|N-acetyllactosamine synthase activity			cervix(1)|endometrium(5)|large_intestine(6)|lung(6)	18	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)		N-Acetyl-D-glucosamine(DB00141)	AGGACCCCGAGGGTCAGTCCC	0.607000													24	29					1.96895e-08	2.07767e-08	1	1	0
HS1BP3	64342	broad.mit.edu	37	2	20818848	20818848	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:20818848G>A	ENST00000304031.3	-	7	1103	c.1078C>T	c.(1078-1080)Cag>Tag	p.Q360*		NM_022460.3	NP_071905.3	Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	360					cell communication		phosphatidylinositol binding			endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	15	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCGGCTTCTGCTGCCCAGCC	0.617000													37	48					0	0	1	0	0
SOX30	11063	broad.mit.edu	37	5	157078120	157078120	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:157078120C>A	ENST00000265007.6	-	1	1308	c.967_splice	c.e1+1	p.G323_splice	SOX30_ENST00000311371.5_Splice_Site_p.G323_splice|SOX30_ENST00000519442.1_Intron	NM_178424.1	NP_848511.1	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30	323					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	23	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGTCTAATACCTGCATCTGAG	0.473000													25	34					1.64293e-13	1.78609e-13	1	1	0
NR2F6	2063	broad.mit.edu	37	19	17343236	17343236	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17343236C>T	ENST00000291442.3	-	4	1859	c.1140G>A	c.(1138-1140)acG>acA	p.T380T		NM_005234.3	NP_005225.2	P10588	NR2F6_HUMAN	nuclear receptor subfamily 2, group F, member 6	380	Important for dimerization (By similarity).|Ligand-binding (By similarity).				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	5						TCTCAATGGGCGTCTTCCCCA	0.667000													5	32					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123246434	123246434	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:123246434G>A	ENST00000264501.4	+	65	11327	c.10954G>A	c.(10954-10956)Gca>Aca	p.A3652T	KIAA1109_ENST00000455637.1_Missense_Mutation_p.A3652T|KIAA1109_ENST00000388738.3_Missense_Mutation_p.A3652T			Q2LD37	K1109_HUMAN	KIAA1109	3652					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TGTGGATGCAGCATCTCCTGG	0.318000													14	69					0	0	1	0	0
TMEM217	221468	broad.mit.edu	37	6	37186425	37186425	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:37186425G>A	ENST00000336655.2	-	2	421	c.382C>T	c.(382-384)Cgc>Tgc	p.R128C	TMEM217_ENST00000356757.2_Missense_Mutation_p.R128C|TMEM217_ENST00000497775.1_Intron	NM_145316.3	NP_660359.2	Q8N7C4	TM217_HUMAN	transmembrane protein 217	128						integral to membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(1)	9						CCAAACCAGCGCATGATTCTG	0.423000													5	112					0	0	1	0	0
STOX2	56977	broad.mit.edu	37	4	184931470	184931470	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:184931470G>A	ENST00000308497.4	+	3	2914	c.1479G>A	c.(1477-1479)tcG>tcA	p.S493S	STOX2_ENST00000438269.1_Silent_p.S493S	NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	493					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		GATCCAGGTCGATGGATAACT	0.572000													7	2					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182542961	182542961	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:182542961C>T	ENST00000295108.3	-	2	1084	c.627G>A	c.(625-627)acG>acA	p.T209T	CERKL_ENST00000479558.1_Intron|NEUROD1_ENST00000496876.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	209					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			AAGCGCTGGCCGTCGGCAGGT	0.612000													17	33					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71683234	71683234	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:71683234C>T	ENST00000393524.2	-	17	4063	c.3330G>A	c.(3328-3330)agG>agA	p.R1110R	PHLPP2_ENST00000356272.3_Silent_p.R1177R|PHLPP2_ENST00000568954.1_Silent_p.R1177R|PHLPP2_ENST00000540628.1_Intron|PHLPP2_ENST00000360429.3_Intron|PHLPP2_ENST00000567016.1_Silent_p.R1212R			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	1177						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						TCTCCAGATCCCTCCCCCTGC	0.542000													31	40					0	0	1	0	0
TMEM215	401498	broad.mit.edu	37	9	32784344	32784344	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:32784344G>A	ENST00000342743.5	+	2	528	c.163G>A	c.(163-165)Gca>Aca	p.A55T		NM_212558.2	NP_997723.2	Q68D42	TM215_HUMAN	transmembrane protein 215	55						integral to membrane				endometrium(4)|kidney(1)|large_intestine(3)|lung(2)|prostate(2)	12						ACCAGGCATCGCAGCCATTGC	0.582000													14	28					0	0	1	0	0
SFTPB	6439	broad.mit.edu	37	2	85890791	85890791	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:85890791G>A	ENST00000342375.3	-	8	987	c.852C>T	c.(850-852)ggC>ggT	p.G284G	SFTPB_ENST00000409383.1_Silent_p.G296G|SFTPB_ENST00000519937.2_Silent_p.G284G|SFTPB_ENST00000393822.3_Silent_p.G296G	NM_000542.3|NM_198843.2	NP_000533.3|NP_942140.2	P07988	PSPB_HUMAN	surfactant protein B	284					organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)	16						GCTCACTTGGGCCAGCGCTGT	0.652000													7	4					0	0	1	0	0
MAP3K1	4214	broad.mit.edu	37	5	56171129	56171129	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:56171129G>A	ENST00000399503.3	+	10	1957	c.1957G>A	c.(1957-1959)Gct>Act	p.A653T		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	653					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		AGTGTACGTTGCTGCTTTAGT	0.423000													8	32					0	0	1	0	0
POLR3A	11128	broad.mit.edu	37	10	79739952	79739952	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:79739952G>A	ENST00000372371.3	-	30	4108	c.3971C>T	c.(3970-3972)aCg>aTg	p.T1324M		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	1324					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			ATGGTCAGCCGTCTTCTCAAA	0.502000													20	23					0	0	1	0	0
DDHD1	0	broad.mit.edu	37	14	53560099	53560099	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:53560099A>C	ENST00000357758.3	-	3	1259	c.1076T>G	c.(1075-1077)cTt>cGt	p.L359R	DDHD1_ENST00000323669.5_Missense_Mutation_p.L359R|DDHD1_ENST00000395606.1_Missense_Mutation_p.L366R	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	359					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					ATCACTATAAAGATATACTTC	0.338000													42	55					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196659286	196659286	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:196659286C>T	ENST00000367429.4	+	9	1493	c.1253C>T	c.(1252-1254)cCt>cTt	p.P418L	CFH_ENST00000439155.2_Missense_Mutation_p.P418L|CFH_ENST00000359637.2_Missense_Mutation_p.P354L	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	418	Sushi 7.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GCCTGCCATCCTGGCTACGCT	0.418000													14	29					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34671822	34671822	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:34671822G>A	ENST00000374789.3	-	9	1370	c.1045C>T	c.(1045-1047)Cgt>Tgt	p.R349C	PARD3_ENST00000374794.3_Missense_Mutation_p.R305C|PARD3_ENST00000350537.4_Missense_Mutation_p.R349C|PARD3_ENST00000374788.3_Missense_Mutation_p.R349C|PARD3_ENST00000374773.1_Missense_Mutation_p.R349C|PARD3_ENST00000545693.1_Missense_Mutation_p.R349C|PARD3_ENST00000374776.1_Missense_Mutation_p.R349C|PARD3_ENST00000346874.4_Missense_Mutation_p.R349C|PARD3_ENST00000544292.1_Missense_Mutation_p.R79C|PARD3_ENST00000374790.3_Missense_Mutation_p.R305C|PARD3_ENST00000545260.1_Missense_Mutation_p.R305C|PARD3_ENST00000340077.5_Missense_Mutation_p.R349C	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	349	PDZ 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				ATGGGTGTACGCATGGCTTGG	0.378000													42	51					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120983805	120983805	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:120983805G>A	ENST00000392793.1	+	5	782	c.511G>A	c.(511-513)Gtg>Atg	p.V171M	TECTA_ENST00000264037.2_Missense_Mutation_p.V171M			O75443	TECTA_HUMAN	tectorin alpha	171	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGCCGTCCTAGTGTCCGATGG	0.582000											OREG0021430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	15					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10432233	10432233	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:10432233C>T	ENST00000245503.5	-	27	3902	c.3518G>A	c.(3517-3519)cGg>cAg	p.R1173Q	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.R1173Q	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1173					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.R1173L(2)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CTCAGCCTCCCGCTTCTTGTT	0.597000													39	82					0	0	1	0	0
C3orf52	79669	broad.mit.edu	37	3	111821806	111821806	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:111821806C>T	ENST00000264848.5	+	3	449	c.390C>T	c.(388-390)acC>acT	p.T130T	C3orf52_ENST00000430855.1_Silent_p.T130T|C3orf52_ENST00000431717.2_Silent_p.T130T	NM_024616.2	NP_078892.2	Q5BVD1	TTMP_HUMAN	chromosome 3 open reading frame 52	130						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4						ACCTGCTCACCGAAAGGGTAA	0.353000													7	16					0	0	1	0	0
MUCL1	118430	broad.mit.edu	37	12	55248906	55248906	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:55248906C>T	ENST00000308796.6	+	2	111	c.65C>T	c.(64-66)cCg>cTg	p.P22L	MUCL1_ENST00000546809.1_Missense_Mutation_p.P17L|MUCL1_ENST00000547990.1_3'UTR	NM_058173.2	NP_477521.1	Q96DR8	MUCL1_HUMAN	mucin-like 1	22						extracellular region|membrane				breast(1)|kidney(1)|lung(1)	3						TCAGAGAATCCGACAACAGCT	0.418000													10	23					0	0	1	0	0
CHDH	55349	broad.mit.edu	37	3	53856558	53856558	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:53856558G>A	ENST00000315251.5	-	4	1252	c.815C>T	c.(814-816)gCa>gTa	p.A272V		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase	272					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	CACGCCCACTGCACGGGTGCC	0.642000													15	18					0	0	1	0	0
ZNF440	126070	broad.mit.edu	37	19	11942387	11942387	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11942387G>T	ENST00000304060.5	+	4	560	c.396G>T	c.(394-396)aaG>aaT	p.K132N		NM_152357.2	NP_689570.2	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(9)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TTGGACACAAGGCATATGAGT	0.413000													73	111					3.83446e-41	4.3104e-41	1	1	0
SZT2	23334	broad.mit.edu	37	1	43903311	43903311	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43903311G>A	ENST00000562955.1	+	44	6165	c.6165G>A	c.(6163-6165)gcG>gcA	p.A2055A	SZT2_ENST00000372442.1_Silent_p.A1213A	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2112						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						AAGGGGATGCGCTGCCCCCTT	0.582000													15	19					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77835490	77835490	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:77835490G>A	ENST00000407578.2	-	12	1934	c.1668C>T	c.(1666-1668)taC>taT	p.Y556Y	MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000544440.2_Silent_p.Y518Y|MYCBP2_ENST00000357337.6_Silent_p.Y518Y	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	518					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CAAGACTCTGGTATTTGCCAG	0.358000													26	9					0	0	1	0	0
TECPR1	25851	broad.mit.edu	37	7	97852477	97852477	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:97852477C>T	ENST00000447648.2	-	21	3052	c.2753G>A	c.(2752-2754)tGc>tAc	p.C918Y	TECPR1_ENST00000379795.3_Missense_Mutation_p.C920Y|TECPR1_ENST00000479975.1_5'UTR			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	918						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CACCAGCTTGCATTTTCTGTA	0.667000													5	2					0	0	1	0	0
SLC39A9	55334	broad.mit.edu	37	14	69921597	69921597	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:69921597G>A	ENST00000031146.4	+	4	1021	c.343G>A	c.(343-345)Gca>Aca	p.A115T	SLC39A9_ENST00000557046.1_Missense_Mutation_p.A158T|SLC39A9_ENST00000555245.1_3'UTR|SLC39A9_ENST00000336643.5_Missense_Mutation_p.A181T|SLC39A9_ENST00000556605.1_Missense_Mutation_p.A181T			Q9NUM3	S39A9_HUMAN	solute carrier family 39, member 9	181					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|skin(1)|stomach(1)	14				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		TGTGTTTGTGGCAATCATGCT	0.363000													5	70					0	0	1	0	0
SNAPC2	6618	broad.mit.edu	37	19	7987037	7987037	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7987037G>A	ENST00000221573.6	+	4	541	c.490G>A	c.(490-492)Gcc>Acc	p.A164T	SNAPC2_ENST00000595035.1_3'UTR|SNAPC2_ENST00000597584.1_5'UTR	NM_003083.3	NP_003074.1	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex, polypeptide 2, 45kDa	164					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						GGAAGACCCCGCCCCTGAAAT	0.657000													30	32					0	0	1	0	0
GTF2F1	2962	broad.mit.edu	37	19	6389529	6389529	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6389529G>A	ENST00000394456.5	-	4	716	c.252C>T	c.(250-252)taC>taT	p.Y84Y	GTF2F1_ENST00000429701.2_Silent_p.Y56Y|CTB-180A7.6_ENST00000599584.1_RNA	NM_002096.2	NP_002087.2	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1, 74kDa	84					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						GGACGATGCCGTACTTCTTCC	0.617000													42	61					0	0	1	0	0
LRIF1	55791	broad.mit.edu	37	1	111492507	111492507	+	Missense_Mutation	SNP	G	G	C	rs144495047	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:111492507G>C	ENST00000369763.4	-	3	2225	c.1835C>G	c.(1834-1836)aCa>aGa	p.T612R	LRIF1_ENST00000485275.2_Missense_Mutation_p.T76R|RP11-96K19.2_ENST00000440689.1_RNA|LRIF1_ENST00000494675.1_Missense_Mutation_p.T76R	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	612					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						CATAAACTCTGTCTCTTTGTA	0.373000													26	38					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72300229	72300229	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:72300229G>A	ENST00000356056.5	-	8	1790	c.1318C>T	c.(1318-1320)Cgg>Tgg	p.R440W	MYO9A_ENST00000563542.1_5'UTR|RP11-390D11.1_ENST00000568391.1_RNA|MYO9A_ENST00000444904.1_Missense_Mutation_p.R421W|MYO9A_ENST00000566885.1_Missense_Mutation_p.R35W|MYO9A_ENST00000564571.1_Missense_Mutation_p.R440W|MYO9A_ENST00000424560.1_Missense_Mutation_p.R440W	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	440	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GAGTCATCCCGGTATGTCTTC	0.343000													13	28					0	0	1	0	0
PIP4K2A	5305	broad.mit.edu	37	10	22830863	22830863	+	Silent	SNP	G	G	A	rs111483402	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:22830863G>A	ENST00000376573.4	-	8	1134	c.906C>T	c.(904-906)ggC>ggT	p.G302G	PIP4K2A_ENST00000323883.7_Silent_p.G162G|PIP4K2A_ENST00000545335.1_Silent_p.G243G	NM_005028.4	NP_005019.2	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	302	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			endometrium(4)|kidney(13)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	29						CATCGCTCTCGCCCTCCTCCT	0.602000													4	36					0	0	1	0	0
PLAA	9373	broad.mit.edu	37	9	26923257	26923257	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:26923257C>T	ENST00000397292.3	-	7	1375	c.958G>A	c.(958-960)Gca>Aca	p.A320T	PLAA_ENST00000520884.1_Missense_Mutation_p.A320T	NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	320					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		TCAATGGTTGCGTGAGACAGT	0.398000													11	121					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90856978	90856978	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:90856978G>A	ENST00000394980.1	+	7	2466	c.2147G>A	c.(2146-2148)cGt>cAt	p.R716H	MMRN1_ENST00000394981.1_Intron|MMRN1_ENST00000264790.2_Missense_Mutation_p.R716H|MMRN1_ENST00000508372.1_Missense_Mutation_p.R458H			Q13201	MMRN1_HUMAN	multimerin 1	716					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TTAGAAAGACGTATCAATGAA	0.313000													19	23					0	0	1	0	0
SRSF4	6429	broad.mit.edu	37	1	29475269	29475269	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:29475269G>A	ENST00000373795.4	-	6	1372	c.1138C>T	c.(1138-1140)Cga>Tga	p.R380*	SRSF4_ENST00000466448.1_5'UTR|SRSF4_ENST00000546138.1_3'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	380	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding	p.R380*(1)		breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						ttgctgcctcgctttctgctc	0.592000													15	28					0	0	1	0	0
GPM6B	2824	broad.mit.edu	37	X	13792708	13792708	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:13792708C>T	ENST00000454189.2	-	7	823	c.696G>A	c.(694-696)gcG>gcA	p.A232A	GPM6B_ENST00000356942.5_Silent_p.A251A|GPM6B_ENST00000398361.3_Silent_p.A165A|GPM6B_ENST00000493677.1_Intron|GPM6B_ENST00000355135.2_Silent_p.A291A|GPM6B_ENST00000316715.4_Intron	NM_001001994.1	NP_001001994.1	Q13491	GPM6B_HUMAN	glycoprotein M6B	251					cell differentiation|nervous system development	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|ovary(1)|pancreas(1)	6						ACTTCAAAACCGCATAGTTAT	0.418000													32	5					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99837486	99837486	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:99837486C>T	ENST00000547776.2	-	11	1539	c.1540G>A	c.(1540-1542)Gcc>Acc	p.A514T	ANKS1B_ENST00000547010.1_Missense_Mutation_p.A94T|ANKS1B_ENST00000329257.7_Missense_Mutation_p.A514T	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	514						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane		p.A514P(1)		NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TTTTTGAGGGCAGTATCAGGG	0.428000													7	42					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32267636	32267636	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:32267636C>T	ENST00000343380.5	-	3	636	c.497G>A	c.(496-498)cGc>cAc	p.R166H		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	166	Leucine-zipper.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						GTCATAGATGCGCCGCTTCTG	0.592000													42	7					0	0	1	0	0
HCRTR1	3061	broad.mit.edu	37	1	32098074	32098074	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32098074G>A	ENST00000373705.1	+	7	1125	c.1125G>A	c.(1123-1125)tcG>tcA	p.S375S	PEF1_ENST00000373703.4_Intron			O43613	OX1R_HUMAN	hypocretin (orexin) receptor 1	375					feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				breast(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	7		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		CCTGCCCATCGTGCCCCGGCC	0.537000													17	22					0	0	1	0	0
SIX6	4990	broad.mit.edu	37	14	60976281	60976281	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:60976281C>T	ENST00000327720.5	+	1	613	c.165C>T	c.(163-165)cgC>cgT	p.R55R		NM_007374.2	NP_031400.2	O95475	SIX6_HUMAN	SIX homeobox 6	55					organ morphogenesis|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(2)	11				OV - Ovarian serous cystadenocarcinoma(108;0.088)		CGGTGCTACGCGCACGAGCCA	0.622000													5	19					0	0	1	0	0
FBXO30	84085	broad.mit.edu	37	6	146126587	146126587	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:146126587C>T	ENST00000237281.4	-	2	1121	c.955G>A	c.(955-957)Gca>Aca	p.A319T		NM_032145.4	NP_115521.3	Q8TB52	FBX30_HUMAN	F-box protein 30	319							ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		TCTGATGATGCCACACAGTCT	0.418000													37	34					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167793914	167793914	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:167793914T>C	ENST00000367848.1	-	27	4151	c.3654A>G	c.(3652-3654)ggA>ggG	p.G1218G	ADCY10_ENST00000367851.4_Silent_p.G1310G|ADCY10_ENST00000545172.1_Silent_p.G1157G|ADCY10_ENST00000485964.1_5'UTR			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1310					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AATCCAGGTGTCCCATTATGA	0.502000													44	65					0	0	1	0	0
HPCAL4	51440	broad.mit.edu	37	1	40149676	40149676	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:40149676G>T	ENST00000372844.3	-	3	702	c.311C>A	c.(310-312)gCc>gAc	p.A104D		NM_016257.2	NP_057341.1	Q9UM19	HPCL4_HUMAN	hippocalcin like 4	104	EF-hand 3.				central nervous system development	intracellular	calcium ion binding			breast(1)|central_nervous_system(1)|lung(5)|stomach(1)	8	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CATCTCAAAGGCCCAGTTGAG	0.657000													8	22					0.000157383	0.000161063	1	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77913290	77913290	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:77913290G>T	ENST00000321110.1	-	2	923	c.628C>A	c.(628-630)Ctg>Atg	p.L210M		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	210							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						AGACCCTCCAGGGACTCCTGG	0.527000													10	4					2.17888e-05	2.24846e-05	1	1	0
COLGALT2	23127	broad.mit.edu	37	1	183938608	183938608	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:183938608C>A	ENST00000361927.4	-	5	999		c.e5-1		COLGALT2_ENST00000546159.1_Splice_Site	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		TATAGAAGCCCTGTAAAAGAG	0.458000													9	18					3.09899e-07	3.24337e-07	1	1	0
VPRBP	9730	broad.mit.edu	37	3	51456180	51456180	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:51456180G>A	ENST00000335891.5	-	8	2049	c.2040C>T	c.(2038-2040)gcC>gcT	p.A680A				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	1129					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		AGTTATAGCTGGCCTCCTCCT	0.507000													38	57					0	0	1	0	0
CLRN2	645104	broad.mit.edu	37	4	17516912	17516912	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:17516912C>T	ENST00000511148.2	+	1	125	c.23C>T	c.(22-24)gCg>gTg	p.A8V		NM_001079827.2	NP_001073296.1	A0PK11	CLRN2_HUMAN	clarin 2	8						integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|upper_aerodigestive_tract(1)	15						TTCAAAAAGGCGTGGTATGGG	0.542000													17	32					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57604585	57604585	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57604585G>A	ENST00000243077.3	+	83	13305	c.12839G>A	c.(12838-12840)aGc>aAc	p.S4280N		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	4280	EGF-like 19.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCCAACAACAGCACCTGCACT	0.672000													19	19					0	0	1	0	0
SWT1	54823	broad.mit.edu	37	1	185259918	185259918	+	Missense_Mutation	SNP	C	C	T	rs140708949		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:185259918C>T	ENST00000367500.4	+	19	2851	c.2686C>T	c.(2686-2688)Ctc>Ttc	p.L896F	SWT1_ENST00000367501.3_Missense_Mutation_p.L896F	NM_017673.6	NP_060143.4	Q5T5J6	SWT1_HUMAN	SWT1 RNA endoribonuclease homolog (S. cerevisiae)	896										breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(16)|ovary(1)|prostate(1)|urinary_tract(1)	41						TGAAGACATGCTCAACTATAG	0.408000													13	22					0	0	1	0	0
CORO6	84940	broad.mit.edu	37	17	27943974	27943974	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27943974G>A	ENST00000345068.5	-	7	1053	c.840C>T	c.(838-840)atC>atT	p.I280I	RP11-68I3.2_ENST00000581474.1_RNA|CORO6_ENST00000388767.3_Silent_p.I280I|CORO6_ENST00000584969.1_Silent_p.I280I|CORO6_ENST00000577909.1_Intron|CORO6_ENST00000580212.1_Silent_p.I240I|CORO6_ENST00000445145.2_Silent_p.I280I|CORO6_ENST00000456796.3_Silent_p.I46I			Q6QEF8	CORO6_HUMAN	coronin 6	280					actin cytoskeleton organization	actin cytoskeleton	actin filament binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(2)	14						ACAGGTAGACGATGCTGGAGT	0.617000													4	67					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47315857	47315857	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:47315857C>T	ENST00000389798.3	+	19	2258	c.2061C>T	c.(2059-2061)ctC>ctT	p.L687L	LRCH1_ENST00000389797.3_Silent_p.L722L|LRCH1_ENST00000311191.6_Intron	NM_015116.2	NP_055931.1	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	687	CH.									breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TGCTGGCACTCGGGGAGAAAG	0.512000													110	155					0	0	1	0	0
ZNF30	90075	broad.mit.edu	37	19	35435319	35435319	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35435319C>T	ENST00000439785.1	+	5	1896	c.1452C>T	c.(1450-1452)ccC>ccT	p.P484P	ZNF30_ENST00000601142.1_Silent_p.P483P|ZNF30_ENST00000426813.2_Silent_p.P402P|ZNF30_ENST00000601957.1_3'UTR|ZNF30_ENST00000303586.7_Silent_p.P484P	NM_001099438.1	NP_001092908.1	P17039	ZNF30_HUMAN	zinc finger protein 30	483					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)	16	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		ATGTAAAGCCCTATGAATGTA	0.433000													8	20					0	0	1	0	0
HDAC7	51564	broad.mit.edu	37	12	48190906	48190906	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48190906C>T	ENST00000080059.7	-	7	596	c.597G>A	c.(595-597)aaG>aaA	p.K199K	HDAC7_ENST00000552960.1_Silent_p.K182K|HDAC7_ENST00000380610.4_Silent_p.K216K|HDAC7_ENST00000354334.3_Silent_p.K199K|HDAC7_ENST00000427332.2_Silent_p.K160K	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	160	Poly-Ser.|Transcription repression 1 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		TATAGCGCAGCTTCAGGTTGG	0.622000													19	25					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13923941	13923941	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13923941C>T	ENST00000254323.2	+	6	1332	c.1143C>T	c.(1141-1143)gaC>gaT	p.D381D	ZSWIM4_ENST00000440752.2_Silent_p.D98D	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	381							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			ACTCCTTCGACGGCCCCAGCC	0.622000													4	12					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003464	122003464	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:122003464C>T	ENST00000498619.1	+	7	3131	c.2693C>T	c.(2692-2694)aCg>aTg	p.T898M	CASR_ENST00000296154.5_Missense_Mutation_p.T888M|CASR_ENST00000490131.1_Missense_Mutation_p.T888M	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	888	Interaction with RNF19A.		R -> Q (in IGE8).		anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GCCCGGGCCACGCTGCGCCGC	0.617000													8	13					0	0	1	0	0
CAPS2	84698	broad.mit.edu	37	12	75678791	75678791	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:75678791G>A	ENST00000393284.3	-	15	1427	c.826C>T	c.(826-828)Cgt>Tgt	p.R276C	CAPS2_ENST00000409445.3_Missense_Mutation_p.R508C|CAPS2_ENST00000409799.1_Missense_Mutation_p.R426C|CAPS2_ENST00000409004.1_5'UTR|RP11-560G2.1_ENST00000549953.1_RNA|CAPS2_ENST00000442339.2_Missense_Mutation_p.R98C			Q9BXY5	CAYP2_HUMAN	calcyphosine 2	508							calcium ion binding			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	10						ATAATACCACGTTTGAATTCT	0.313000													23	34					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49713566	49713566	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49713566C>T	ENST00000252826.5	+	21	3358	c.3232C>T	c.(3232-3234)Ccc>Tcc	p.P1078S	TRPM4_ENST00000427978.2_Missense_Mutation_p.P933S|TRPM4_ENST00000355712.5_Missense_Mutation_p.P724S	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	1078	Calmodulin-binding.				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GCTGGCCCCGCCCTTTATCGT	0.627000													18	31					0	0	1	0	0
RGS13	6003	broad.mit.edu	37	1	192628557	192628557	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:192628557C>T	ENST00000391995.2	+	7	672	c.384C>T	c.(382-384)gtC>gtT	p.V128V	RGS13_ENST00000482095.1_3'UTR|RGS13_ENST00000543215.1_Silent_p.V128V	NM_002927.4	NP_002918.1	O14921	RGS13_HUMAN	regulator of G-protein signaling 13	128	RGS.					plasma membrane	GTPase activator activity|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|skin(1)	19						AGAAAATAGTCTATATGCATA	0.368000													31	20					0	0	1	0	0
GALNT16	57452	broad.mit.edu	37	14	69800217	69800217	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:69800217G>A	ENST00000337827.4	+	9	1194	c.867G>A	c.(865-867)acG>acA	p.T289T	GALNT16_ENST00000448469.3_Silent_p.T289T|GALNT16_ENST00000553669.1_Silent_p.T289T	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		CTCCCAGGACGCCTGTCATAG	0.547000													20	41					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92671655	92671655	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:92671655C>T	ENST00000318445.6	+	7	1662	c.1448C>T	c.(1447-1449)aCt>aTt	p.T483I	SLCO3A1_ENST00000555549.1_3'UTR|SLCO3A1_ENST00000424469.2_Missense_Mutation_p.T483I	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	483	Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			GATTCCTTCACTCCAGTGTGT	0.567000													30	52					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27788316	27788316	+	Missense_Mutation	SNP	C	C	T	rs150197704		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:27788316C>T	ENST00000261588.4	+	25	4536	c.4517C>T	c.(4516-4518)gCg>gTg	p.A1506V		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1506								p.A1506V(2)		breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						TGGAATTATGCGAAAACACCC	0.443000													14	176					0	0	1	0	0
SEPT8	23176	broad.mit.edu	37	5	132099517	132099517	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:132099517G>A	ENST00000296873.7	-	4	698	c.415C>T	c.(415-417)Cgc>Tgc	p.R139C	SEPT8_ENST00000378699.2_Missense_Mutation_p.R79C|SEPT8_ENST00000378706.1_Missense_Mutation_p.R139C|SEPT8_ENST00000378701.1_Missense_Mutation_p.R137C|SEPT8_ENST00000378719.2_Missense_Mutation_p.R139C|SEPT8_ENST00000378721.4_Missense_Mutation_p.R137C|SEPT8_ENST00000448933.1_Missense_Mutation_p.R79C|SEPT8_ENST00000458488.2_Missense_Mutation_p.R139C	NM_001098812.1|NM_015146.1	NP_001092282.1|NP_055961.1	Q92599	SEPT8_HUMAN	septin 8	139					cell cycle	septin complex	GTP binding|protein binding		SEPT8/AFF4(2)	kidney(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	11		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGCGAGCGGCGGATCTTCAGC	0.522000											OREG0003468	type=REGULATORY REGION|Gene=LOC540614|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	48	67					0	0	1	0	0
FMO5	2330	broad.mit.edu	37	1	146684990	146684990	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:146684990G>A	ENST00000254090.4	-	4	760	c.372C>T	c.(370-372)ggC>ggT	p.G124G	FMO5_ENST00000369272.3_Silent_p.G124G|FMO5_ENST00000441068.2_Silent_p.G124G|FMO5_ENST00000465173.1_5'UTR	NM_001461.2	NP_001452.2	P49326	FMO5_HUMAN	flavin containing monooxygenase 5	124						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	25	all_hematologic(923;0.0487)					CTTCCCATTGGCCTGAAGTGG	0.478000													72	108					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22990104	22990104	+	Silent	SNP	C	C	T	rs145238748		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:22990104C>T	ENST00000313077.7	+	24	2849	c.2724C>T	c.(2722-2724)ttC>ttT	p.F908F	CYFIP1_ENST00000560848.1_Silent_p.F908F|CYFIP1_ENST00000435939.2_Silent_p.F477F	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	908					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		ACCGGAACTTCGTGGGACCTC	0.567000													52	65					0	0	1	0	0
TSSC1	7260	broad.mit.edu	37	2	3200658	3200658	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:3200658C>A	ENST00000398659.4	-	7	868	c.728G>T	c.(727-729)aGc>aTc	p.S243I	TSSC1_ENST00000478754.1_5'UTR|TSSC1_ENST00000382125.4_Missense_Mutation_p.S216I			Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	216							protein binding			breast(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	18	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		TGACCTCATGCTCCGGGTGTC	0.627000													4	10					1	1	1	1	0
TRDMT1	1787	broad.mit.edu	37	10	17216557	17216557	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:17216557G>A	ENST00000457442.2	-	2	383	c.67C>T	c.(67-69)Cga>Tga	p.R23*	TRDMT1_ENST00000358282.7_Missense_Mutation_p.T56M|TRDMT1_ENST00000377799.3_Missense_Mutation_p.T56M|TRDMT1_ENST00000377766.5_Missense_Mutation_p.T56M|TRDMT1_ENST00000412821.3_Missense_Mutation_p.T56M|TRDMT1_ENST00000488990.1_Missense_Mutation_p.T56M|TRDMT1_ENST00000351358.4_Missense_Mutation_p.T56M			O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1	0					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	18						CACTTCAATCGTCTTGGCAAG	0.378000													26	41					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27493529	27493529	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27493529G>A	ENST00000527372.1	-	2	610	c.430C>T	c.(430-432)Cgt>Tgt	p.R144C	MYO18A_ENST00000354329.4_Missense_Mutation_p.R144C|MYO18A_ENST00000533112.1_Missense_Mutation_p.R144C|MYO18A_ENST00000531253.1_Missense_Mutation_p.R144C	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	144					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TCCCGGCTACGCTGGGAGAAG	0.622000													13	17					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129214427	129214427	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:129214427C>T	ENST00000296266.3	+	19	2530	c.2338C>T	c.(2338-2340)Ctc>Ttc	p.L780F	IFT122_ENST00000349441.2_Missense_Mutation_p.L618F|IFT122_ENST00000347300.2_Missense_Mutation_p.L670F|IFT122_ENST00000348417.2_Missense_Mutation_p.L729F|IFT122_ENST00000440957.2_Missense_Mutation_p.L520F|IFT122_ENST00000504021.1_Missense_Mutation_p.L605F|IFT122_ENST00000507564.1_Missense_Mutation_p.L721F|IFT122_ENST00000513932.1_3'UTR|IFT122_ENST00000431818.2_Missense_Mutation_p.L579F	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	729					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						GTACACCGACCTCTGCATGTT	0.532000													18	18					0	0	1	0	0
PCDHB14	0	broad.mit.edu	37	5	140604449	140604449	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140604449C>A	ENST00000239449.4	+	1	1372	c.1372C>A	c.(1372-1374)Ctg>Atg	p.L458M	PCDHB14_ENST00000515856.2_Missense_Mutation_p.L305M	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		458	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCTACACCCTGTTCGTCCG	0.592000													18	87					8.10497e-08	8.52441e-08	1	1	0
ZBTB20	26137	broad.mit.edu	37	3	114058118	114058118	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:114058118G>A	ENST00000462705.1	-	12	2562	c.1741C>T	c.(1741-1743)Cgc>Tgc	p.R581C	ZBTB20_ENST00000357258.3_Missense_Mutation_p.R581C|ZBTB20_ENST00000464560.1_Missense_Mutation_p.R581C|ZBTB20_ENST00000481632.1_Missense_Mutation_p.R581C|ZBTB20_ENST00000471418.1_Missense_Mutation_p.R581C|ZBTB20_ENST00000474710.1_Missense_Mutation_p.R654C|ZBTB20_ENST00000393785.2_Missense_Mutation_p.R581C	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	654					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CGGTGGAGGCGCATGTGCACG	0.552000													50	76					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21226053	21226053	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:21226053G>T	ENST00000233242.1	-	29	12368	c.12241C>A	c.(12241-12243)Ctt>Att	p.L4081I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4081					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TAATCATAAAGGACCCCTGTG	0.468000													81	88					2.37601e-23	2.64711e-23	1	1	0
RFC1	5981	broad.mit.edu	37	4	39304196	39304196	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:39304196G>A	ENST00000381897.1	-	18	2496	c.2363C>T	c.(2362-2364)gCa>gTa	p.A788V	RFC1_ENST00000349703.2_Missense_Mutation_p.A787V	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	788					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						TTCTTTAAATGCAATAGACAT	0.308000													15	20					0	0	1	0	0
PCDHA11	0	broad.mit.edu	37	5	140249998	140249998	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140249998C>T	ENST00000398640.2	+	1	1310	c.1310C>T	c.(1309-1311)aCg>aTg	p.T437M	PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTGGGCCACGGCCAGGGTA	0.637000													60	85					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77713379	77713379	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:77713379G>A	ENST00000407578.2	-	52	7877	c.7611C>T	c.(7609-7611)tgC>tgT	p.C2537C	MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000544440.2_Silent_p.C2499C|MYCBP2_ENST00000357337.6_Silent_p.C2499C	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2499					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TAAAAGAGAGGCACCAGGCTT	0.388000													49	21					0	0	1	0	0
GP5	2814	broad.mit.edu	37	3	194117532	194117532	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:194117532G>A	ENST00000401815.1	-	1	1551	c.1480C>T	c.(1480-1482)Cca>Tca	p.P494S	GP5_ENST00000323007.3_Missense_Mutation_p.P494S			P40197	GPV_HUMAN	glycoprotein V (platelet)	494					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				breast(3)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(14)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	35	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		GCCAAGGCTGGGTGGACAGGG	0.697000													36	40					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15714696	15714696	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:15714696C>A	ENST00000378076.3	-	7	1082	c.729G>T	c.(727-729)aaG>aaT	p.K243N		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	243					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TGAGGATATCCTTGAATGAGT	0.423000													28	37					2.12542e-12	2.29988e-12	1	1	0
FBP1	2203	broad.mit.edu	37	9	97380094	97380094	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:97380094C>T	ENST00000415431.1	-	4	611	c.382G>A	c.(382-384)Gat>Aat	p.D128N	FBP1_ENST00000375326.4_Missense_Mutation_p.D128N	NM_001127628.1	NP_001121100.1	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	128					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding			kidney(1)|liver(1)|lung(1)	3		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	ACAAGGCAATCGATGTTGGAA	0.383000													16	35					0	0	1	0	0
RCN3	57333	broad.mit.edu	37	19	50031839	50031839	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50031839C>T	ENST00000270645.3	+	2	557	c.110C>T	c.(109-111)gCg>gTg	p.A37V	RCN3_ENST00000593644.1_3'UTR	NM_020650.2	NP_065701.2	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	37						endoplasmic reticulum lumen	calcium ion binding|protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		GTGCACCAGGCGGCCCCCCTG	0.642000													26	45					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1268453	1268453	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:1268453C>T	ENST00000447027.1	+	31	10410	c.10352C>T	c.(10351-10353)cCg>cTg	p.P3451L	MUC5B_ENST00000529681.1_Missense_Mutation_p.P3448L|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3448	17 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCCCAGTGCCGAACACCACG	0.692000													5	19					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	5811651	5811651	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:5811651C>T	ENST00000381095.3	-	6	2285	c.1658G>A	c.(1657-1659)cGc>cAc	p.R553H	NLGN4X_ENST00000381092.1_Missense_Mutation_p.R553H|NLGN4X_ENST00000381093.2_Missense_Mutation_p.R573H|NLGN4X_ENST00000275857.6_Missense_Mutation_p.R553H|NLGN4X_ENST00000538097.1_Missense_Mutation_p.R553H	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	553					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						TTCTTCAAAGCGGTTGGGTTT	0.443000													30	7					0	0	1	0	0
CD9	928	broad.mit.edu	37	12	6342621	6342621	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6342621C>T	ENST00000382518.1	+	5	753	c.317C>T	c.(316-318)gCg>gTg	p.A106V	CD9_ENST00000382515.2_Missense_Mutation_p.A37V|CD9_ENST00000009180.4_Missense_Mutation_p.A106V|CD9_ENST00000481267.1_3'UTR			P21926	CD9_HUMAN	CD9 molecule	106					cell adhesion|cellular component movement|fusion of sperm to egg plasma membrane|paranodal junction assembly|platelet activation|platelet degranulation	integral to plasma membrane|platelet alpha granule membrane				endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|stomach(1)	8						GAAATAGCTGCGGCCATCTGG	0.542000													24	34					0	0	1	0	0
MYCT1	80177	broad.mit.edu	37	6	153042909	153042909	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:153042909G>A	ENST00000367245.5	+	2	237	c.229G>A	c.(229-231)Gca>Aca	p.A77T	MYCT1_ENST00000529453.1_Intron	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	77						nucleus				NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		TGTATCCATGGCAATCGGGCT	0.413000													39	60					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130647904	130647904	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:130647904C>T	ENST00000539839.1	+	1	901	c.319C>T	c.(319-321)Caa>Taa	p.Q107*	FZD10_ENST00000229030.4_Silent_p.N139N	NM_007197.3	NP_009128.1	Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	0	FZ.				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		AACTCCCCAACAAGAACGACC	0.662000													29	55					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1256370	1256370	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:1256370G>A	ENST00000447027.1	+	22	2753	c.2695G>A	c.(2695-2697)Gtg>Atg	p.V899M	MUC5B_ENST00000529681.1_Missense_Mutation_p.V896M			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	896	VWFC 1.|VWFD 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGGCACCTGCGTGGCCTACGG	0.652000													14	16					0	0	1	0	0
CAMK2D	817	broad.mit.edu	37	4	114530360	114530360	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:114530360G>A	ENST00000454265.2	-	4	1081	c.223C>T	c.(223-225)Cga>Tga	p.R75*	CAMK2D_ENST00000429180.1_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000511664.1_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000508738.1_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000342666.5_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000379773.2_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000394526.2_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000394522.3_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000505990.1_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000515496.1_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000418639.2_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000514328.1_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000394524.3_Nonsense_Mutation_p.R75*|CAMK2D_ENST00000296402.5_Nonsense_Mutation_p.R75*			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	75	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		TCATGAAGTCGCACTAGAAAA	0.348000													18	37					0	0	1	0	0
LYPLA2	11313	broad.mit.edu	37	1	24120858	24120858	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24120858C>A	ENST00000374502.3	+	8	570	c.514C>A	c.(514-516)Ctc>Atc	p.L172I	LYPLA2_ENST00000374501.1_Intron|LYPLA2_ENST00000374514.3_Intron|LYPLA2_ENST00000400061.1_Intron|LYPLA2_ENST00000374505.2_3'UTR|LYPLA2_ENST00000374503.3_Intron|LYPLA2_ENST00000495365.1_Intron			O95372	LYPA2_HUMAN	lysophospholipase II	0					fatty acid metabolic process	cytoplasm	hydrolase activity			endometrium(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		TGTCTGCATCCTCGTGGCTTG	0.642000													10	15					2.74318e-10	2.93027e-10	1	1	0
OR10K1	391109	broad.mit.edu	37	1	158435852	158435852	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158435852C>A	ENST00000289451.2	+	1	581	c.501C>A	c.(499-501)ccC>ccA	p.P167P		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TTCATCTGCCCTTCCACTCCT	0.537000													15	105					1.15088e-07	1.20771e-07	1	1	0
OPN3	23596	broad.mit.edu	37	1	241767867	241767867	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:241767867C>T	ENST00000366554.2	-	2	494	c.388G>A	c.(388-390)Gcc>Acc	p.A130T	OPN3_ENST00000469376.1_5'UTR|OPN3_ENST00000331838.5_Intron	NM_014322.2	NP_055137.2	Q9H1Y3	OPN3_HUMAN	opsin 3	130					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|visual perception	integral to plasma membrane	G-protein coupled photoreceptor activity			endometrium(1)|large_intestine(5)|lung(5)	11	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			GTTAGGGTGGCAATGGAAACA	0.498000													8	12					0	0	1	0	0
TOB1	10140	broad.mit.edu	37	17	48940438	48940438	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48940438C>T	ENST00000499247.2	-	2	1374	c.941G>A	c.(940-942)gGa>gAa	p.G314E	TOB1_ENST00000268957.3_Missense_Mutation_p.G314E	NM_001243885.1|NM_005749.3	NP_001230814.1|NP_005740.1	P50616	TOB1_HUMAN	transducer of ERBB2, 1	314					negative regulation of cell proliferation		SH3/SH2 adaptor activity			breast(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			ATTGAGGCCTCCATAGGCTGC	0.423000													23	31					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113803437	113803437	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113803437C>T	ENST00000375559.3	+	8	1111	c.1073C>T	c.(1072-1074)aCg>aTg	p.T358M	F10_ENST00000375551.3_3'UTR|F10_ENST00000409306.1_3'UTR	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X	358	Peptidase S1.		T -> M (in FA10D; Roma).		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACGCAGAAGACGGGGATTGTG	0.662000													10	21					0	0	1	0	0
ANKRD13B	124930	broad.mit.edu	37	17	27939517	27939517	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27939517C>T	ENST00000394859.3	+	12	1510	c.1356C>T	c.(1354-1356)agC>agT	p.S452S	RP11-68I3.2_ENST00000581474.1_RNA	NM_152345.4	NP_689558.4	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	452	Ser-rich.									cervix(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	16						GCCCCAGCAGCGAGACGCCTT	0.682000													2	0					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4917279	4917279	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:4917279G>A	ENST00000399583.3	-	2	679	c.492C>T	c.(490-492)gaC>gaT	p.D164D	RADIL_ENST00000536091.1_Silent_p.D164D	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	164	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GCTCCTCCACGTCCGACCTCT	0.597000													8	19					0	0	1	0	0
RPGR	6103	broad.mit.edu	37	X	38147244	38147244	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:38147244G>A	ENST00000378505.2	-	14	1799	c.1623C>T	c.(1621-1623)aaC>aaT	p.N541N	RPGR_ENST00000309513.3_Silent_p.N479N|RPGR_ENST00000342811.3_Silent_p.N541N|RPGR_ENST00000339363.3_Silent_p.N541N|TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000338898.3_3'UTR|RPGR_ENST00000318842.7_Silent_p.N541N	NM_001034853.1	NP_001030025.1	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	541	Glu-rich.				intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						CACTATCATCGTTTTCAGTAA	0.358000													40	11					0	0	1	0	0
RGMB	285704	broad.mit.edu	37	5	98128863	98128863	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:98128863G>A	ENST00000308234.7	+	5	1245	c.843G>A	c.(841-843)ccG>ccA	p.P281P	RGMB_ENST00000513185.1_Silent_p.P240P	NM_001012761.2	NP_001012779.2	Q6NW40	RGMB_HUMAN	repulsive guidance molecule family member b	240					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	10		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		ATGACCTGCCGGCCGCCTTTG	0.542000													10	8					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58384980	58384980	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58384980C>T	ENST00000435989.2	-	3	2012	c.1778G>A	c.(1777-1779)aGc>aAc	p.S593N	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000600634.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	593					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						GCGCTGATGGCTCCTAAGGTG	0.478000													14	15					0	0	1	0	0
SPATA20	64847	broad.mit.edu	37	17	48628950	48628950	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48628950C>T	ENST00000006658.6	+	13	1775	c.1655C>T	c.(1654-1656)gCc>gTc	p.A552V	SPATA20_ENST00000356488.4_Missense_Mutation_p.A536V|SPATA20_ENST00000393244.3_Missense_Mutation_p.A492V|SPATA20_ENST00000511937.1_3'UTR	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	536					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			ACCAATGGTGCCAAGTTCCTG	0.602000													30	34					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410002	159410002	+	Missense_Mutation	SNP	C	C	T	rs139843472	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:159410002C>T	ENST00000423932.3	+	1	491	c.454C>T	c.(454-456)Cgt>Tgt	p.R152C	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	152					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					CAAGAGGCTGCGTATCCAACT	0.498000													50	73					0	0	1	0	0
PIK3R6	146850	broad.mit.edu	37	17	8742973	8742973	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8742973G>A	ENST00000311434.9	-	3	294	c.55C>T	c.(55-57)Cgg>Tgg	p.R19W	PIK3R6_ENST00000434064.2_5'UTR	NM_001010855.2	NP_001010855.1	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	19					platelet activation	cytosol											CTGAGCTCCCGGAGCACAGCC	0.647000													4	2					0	0	1	0	0
HOXC4	3221	broad.mit.edu	37	12	54448817	54448817	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:54448817G>A	ENST00000430889.2	+	2	669	c.623G>A	c.(622-624)cGc>cAc	p.R208H	HOXC4_ENST00000303406.4_Missense_Mutation_p.R208H	NM_153633.2	NP_705897.1	P09017	HXC4_HUMAN	homeobox C4	208						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	13						CAAAACCGTCGCATGAAATGG	0.587000													9	11					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24532006	24532006	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24532006G>A	ENST00000342740.5	+	29	2811	c.2657G>A	c.(2656-2658)cGg>cAg	p.R886Q	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	886										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GGCCGAGGCCGGAACCATGAC	0.632000													18	20					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79933569	79933569	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:79933569G>A	ENST00000281127.7	+	2	1132	c.253G>A	c.(253-255)Gct>Act	p.A85T	NRXN3_ENST00000335750.5_Missense_Mutation_p.A717T|NRXN3_ENST00000554719.1_Missense_Mutation_p.A717T|NRXN3_ENST00000557594.1_Missense_Mutation_p.A85T|NRXN3_ENST00000556003.1_3'UTR|NRXN3_ENST00000428277.2_Missense_Mutation_p.A85T	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	85	Laminin G-like.				angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TGCAGCTGGCGCTACGTACAT	0.557000													12	19					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127797548	127797548	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:127797548C>A	ENST00000556132.1	-	6	2487	c.1623G>T	c.(1621-1623)aaG>aaT	p.K541N	SOGA3_ENST00000481848.2_Missense_Mutation_p.K541N|SOGA3_ENST00000368268.2_Missense_Mutation_p.K541N|SOGA3_ENST00000525778.1_Missense_Mutation_p.K541N|SOGA3_ENST00000465909.2_Missense_Mutation_p.K541N	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	541						integral to membrane											TGGCCATTTTCTTTCTCATCA	0.443000													31	76					9.80977e-26	1.09576e-25	1	1	0
MUC5B	727897	broad.mit.edu	37	11	1247968	1247968	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:1247968G>A	ENST00000447027.1	+	4	381	c.323G>A	c.(322-324)cGc>cAc	p.R108H	MUC5B_ENST00000529681.1_Missense_Mutation_p.R108H			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	108	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GAGCACTGCCGCGCCGCCTAC	0.632000													8	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9066188	9066188	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9066188G>A	ENST00000397910.4	-	3	21461	c.21258C>T	c.(21256-21258)agC>agT	p.S7086S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7088	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGAGGGAGAGCTTTGCCATG	0.498000													18	17					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30748453	30748453	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30748453G>A	ENST00000262518.4	+	34	7477	c.7092G>A	c.(7090-7092)ccG>ccA	p.P2364P	SRCAP_ENST00000344771.4_Silent_p.P2206P|SRCAP_ENST00000395059.2_Silent_p.P2302P	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2364					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			AGGAGGGGCCGGGGGCTGGGG	0.637000													11	19					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16262309	16262309	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16262309C>T	ENST00000375759.3	+	11	9778	c.9574C>T	c.(9574-9576)Cca>Tca	p.P3192S		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3192					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CTATACTGTGCCACGGGATGT	0.602000													8	47					0	0	1	0	0
ZFP36L2	678	broad.mit.edu	37	2	43452332	43452332	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:43452332C>T	ENST00000282388.3	-	2	904	c.611G>A	c.(610-612)gGc>gAc	p.G204D	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	204	RNA-binding.				cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GGGGCAGAAGCCGATGGTATG	0.677000													8	13					0	0	1	0	0
PRRC1	133619	broad.mit.edu	37	5	126883555	126883555	+	Missense_Mutation	SNP	G	G	A	rs139023434		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:126883555G>A	ENST00000442138.2	+	8	1216	c.1070G>A	c.(1069-1071)gGc>gAc	p.G357D	PRRC1_ENST00000512635.2_Missense_Mutation_p.G357D|PRRC1_ENST00000296666.8_Missense_Mutation_p.G357D|PRRC1_ENST00000513427.1_3'UTR			Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	357						Golgi apparatus				endometrium(1)|large_intestine(1)|lung(4)	6		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		CCTGTCCATGGCATTCATCTA	0.383000													14	40					0	0	1	0	0
ILF2	3608	broad.mit.edu	37	1	153635494	153635494	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:153635494C>T	ENST00000361891.4	-	12	1047		c.e12+1		ILF2_ENST00000480213.1_Splice_Site	NM_001267809.1|NM_004515.3	NP_001254738.1|NP_004506.2	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2						immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity			cervix(1)|kidney(1)|lung(4)|skin(1)	7	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGTCCCAATACCTGCTGTTCT	0.493000													13	21					0	0	1	0	0
ZNF583	147949	broad.mit.edu	37	19	56935181	56935181	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56935181G>A	ENST00000333201.9	+	5	1364	c.1154G>A	c.(1153-1155)tGt>tAt	p.C385Y	ZNF583_ENST00000585612.1_Intron|ZNF583_ENST00000291598.7_Missense_Mutation_p.C385Y	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		TGTAAGGAATGTAGGAAAGCC	0.418000													24	39					0	0	1	0	0
HK1	3098	broad.mit.edu	37	10	71055391	71055391	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:71055391T>C	ENST00000448642.2	+	6	512	c.123T>C	c.(121-123)gcT>gcC	p.A41A	HK1_ENST00000404387.2_Silent_p.A10A|HK1_ENST00000360289.2_5'UTR			P19367	HXK1_HUMAN	hexokinase 1	0	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						TCTCTAAGGCTACAGCAGCTG	0.323000													7	56					0	0	1	0	0
FRS3	10817	broad.mit.edu	37	6	41738969	41738969	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:41738969G>A	ENST00000373018.3	-	7	1118	c.867C>T	c.(865-867)aaC>aaT	p.N289N	FRS3_ENST00000259748.2_Silent_p.N289N	NM_006653.3	NP_006644.1	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	289					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCCCGGTGACGTTCTCGTAGG	0.662000													12	20					0	0	1	0	0
RRM2	6241	broad.mit.edu	37	2	10267220	10267220	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:10267220G>A	ENST00000360566.2	+	7	1142	c.851G>A	c.(850-852)cGt>cAt	p.R284H	RRM2_ENST00000304567.5_Missense_Mutation_p.R224H	NM_001165931.1	NP_001159403.1	P31350	RIR2_HUMAN	ribonucleotide reductase M2	224					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding	p.R284H(1)|p.R224H(1)		NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|skin(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		ATAGGTGAACGTGTTGTAGCC	0.423000													47	94					0	0	1	0	0
F2RL1	2150	broad.mit.edu	37	5	76129237	76129237	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:76129237C>A	ENST00000296677.4	+	2	1011	c.805C>A	c.(805-807)Ctg>Atg	p.L269M		NM_005242.4	NP_005233.3	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	269					blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	13		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		GATCAGAATGCTGCGATCTTC	0.498000													41	71					2.87052e-16	3.15041e-16	1	1	0
KRT40	125115	broad.mit.edu	37	17	39139338	39139338	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39139338G>A	ENST00000377755.4	-	2	524	c.490C>T	c.(490-492)Ctt>Ttt	p.L164F	KRT40_ENST00000398486.2_Missense_Mutation_p.L164F			Q6A162	K1C40_HUMAN	keratin 40	164	Coil 1B.|Rod.					intermediate filament	structural molecule activity			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Breast(137;0.00043)				CAGTTGTCAAGCTGTACAGCA	0.328000													83	138					0	0	1	0	0
NDE1	54820	broad.mit.edu	37	16	15771786	15771786	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:15771786C>T	ENST00000396355.1	+	5	1192	c.366C>T	c.(364-366)gaC>gaT	p.D122D	NDE1_ENST00000396353.2_Silent_p.D122D|NDE1_ENST00000396354.1_Silent_p.D122D|NDE1_ENST00000342673.5_Silent_p.D122D	NM_001143979.1	NP_001137451.1	Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	122	Interaction with PAFAH1B1 (By similarity).				cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						AAGCAAATGACGACCTGGAAA	0.542000													12	23					0	0	1	0	0
GCDH	2639	broad.mit.edu	37	19	13008631	13008631	+	Silent	SNP	C	C	T	rs139344943	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13008631C>T	ENST00000222214.5	+	11	1408	c.1197C>T	c.(1195-1197)caC>caT	p.H399H	GCDH_ENST00000591470.1_Silent_p.H399H|GCDH_ENST00000457854.1_Silent_p.H399H|GCDH_ENST00000422947.2_Silent_p.H355H			Q92947	GCDH_HUMAN	glutaryl-CoA dehydrogenase	399					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)	19						ACGAGTATCACGTGATCCGGC	0.597000													20	30					0	0	1	0	0
GRAMD1A	57655	broad.mit.edu	37	19	35510429	35510429	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35510429G>A	ENST00000599564.1	+	14	1799	c.1728G>A	c.(1726-1728)gcG>gcA	p.A576A	GRAMD1A_ENST00000504615.2_Silent_p.A255A|CTD-2527I21.14_ENST00000605640.1_RNA|GRAMD1A_ENST00000411896.2_Silent_p.A482A|GRAMD1A_ENST00000317991.5_Silent_p.A489A			Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A	489						integral to membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GGAACAAGGCGCGGCTCCGGT	0.662000													43	52					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639505	7639505	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:7639505C>T	ENST00000359156.4	-	9	2330	c.2128G>A	c.(2128-2130)Gct>Act	p.A710T	CD163_ENST00000432237.2_Missense_Mutation_p.A710T|CD163_ENST00000541972.1_Missense_Mutation_p.A698T|CD163_ENST00000396620.3_Missense_Mutation_p.A743T	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	710					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CAGGCCACAGCACTTTCTTCT	0.418000													27	53					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127682079	127682079	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:127682079C>A	ENST00000405109.1	+	5	2007	c.1540C>A	c.(1540-1542)Ctt>Att	p.L514I	KBTBD12_ENST00000407609.3_Missense_Mutation_p.L121I|KBTBD12_ENST00000492025.1_3'UTR|KBTBD12_ENST00000343941.4_Missense_Mutation_p.L89I|KBTBD12_ENST00000405256.1_Missense_Mutation_p.L514I			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	514										endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						TCGAAAATGCCTTGACGTGGT	0.522000													5	9					3.59834e-05	3.7043e-05	1	1	0
ZNF679	168417	broad.mit.edu	37	7	63726748	63726748	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:63726748G>A	ENST00000421025.1	+	5	1006	c.737G>A	c.(736-738)gGc>gAc	p.G246D	ZNF679_ENST00000255746.4_Missense_Mutation_p.G246D	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						GAGGAATGTGGCAAAGCTTTT	0.428000													14	28					0	0	1	0	0
C5orf22	55322	broad.mit.edu	37	5	31551423	31551423	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:31551423C>T	ENST00000355907.3	+	9	1408	c.246C>T	c.(244-246)tgC>tgT	p.C82C	C5orf22_ENST00000325366.9_Silent_p.C361C|C5orf22_ENST00000504866.1_3'UTR			Q49AR2	CE022_HUMAN	chromosome 5 open reading frame 22	361										kidney(3)|large_intestine(2)|lung(10)|ovary(2)|skin(1)	18						GTTTAACCTGCGATTATTCAG	0.328000													52	83					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41766371	41766371	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:41766371G>A	ENST00000379483.3	-	1	2331	c.2023C>T	c.(2023-2025)Cga>Tga	p.R675*		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	675							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		TGTGCATTTCGCTGAGGTGCT	0.398000													42	52					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162622263	162622263	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:162622263C>A	ENST00000366898.1	-	4	536	c.434G>T	c.(433-435)aGc>aTc	p.S145I	PARK2_ENST00000366892.1_Missense_Mutation_p.S145I|PARK2_ENST00000338468.3_Intron|PARK2_ENST00000366897.1_Missense_Mutation_p.S145I|PARK2_ENST00000366896.1_Intron|PARK2_ENST00000366894.1_5'UTR	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	145					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CACATAAAAGCTGTTGTAGAT	0.458000													21	41					3.08376e-08	3.24969e-08	1	1	0
SYT6	148281	broad.mit.edu	37	1	114680411	114680411	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:114680411C>A	ENST00000393296.1	-	3	854	c.777G>T	c.(775-777)aaG>aaT	p.K259N	SYT6_ENST00000369547.1_Missense_Mutation_p.K174N			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	259	C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACAAAAGTCCTTGGCAGGGA	0.552000													23	50					7.87624e-14	8.57347e-14	1	1	0
DCHS2	54798	broad.mit.edu	37	4	155254288	155254288	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:155254288G>A	ENST00000357232.3	-	9	1574	c.1575C>T	c.(1573-1575)ggC>ggT	p.G525G	DCHS2_ENST00000339452.1_Silent_p.G1024G|DCHS2_ENST00000507542.1_5'UTR	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	525	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGCAAAGACGCCTGGCTGCG	0.682000													7	12					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7709605	7709605	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7709605C>T	ENST00000441779.2	+	14	1283	c.1246C>T	c.(1246-1248)Cgg>Tgg	p.R416W	STXBP2_ENST00000221283.5_Missense_Mutation_p.R405W|STXBP2_ENST00000414284.2_Missense_Mutation_p.R402W	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	405					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						CGACAAGATCCGGGTCCTGCT	0.632000													16	20					0	0	1	0	0
TTC19	54902	broad.mit.edu	37	17	15905279	15905279	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:15905279C>T	ENST00000261647.5	+	3	832	c.363C>T	c.(361-363)gaC>gaT	p.D121D	TTC19_ENST00000486880.2_Silent_p.D242D|TTC19_ENST00000497842.2_3'UTR	NM_017775.3	NP_060245.3	Q6DKK2	TTC19_HUMAN	tetratricopeptide repeat domain 19	121					cell cycle|cytokinesis|mitochondrial respiratory chain complex III assembly	centrosome|midbody|mitochondrial inner membrane	protein binding	p.D242D(1)		central_nervous_system(1)|lung(2)|skin(1)|stomach(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TTTTGCATGACGCTCTTCGTC	0.383000													19	33					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64676265	64676265	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:64676265C>T	ENST00000357395.3	+	103	18808	c.7664C>T	c.(7663-7665)aCg>aTg	p.T2555M	SYNE2_ENST00000358025.3_Missense_Mutation_p.T6170M|SYNE2_ENST00000554584.1_Missense_Mutation_p.T6132M|SYNE2_ENST00000344113.4_Missense_Mutation_p.T6170M|SYNE2_ENST00000555022.1_Missense_Mutation_p.T48M|SYNE2_ENST00000554805.1_5'UTR|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000555002.1_Missense_Mutation_p.T2804M|SYNE2_ENST00000394768.2_Missense_Mutation_p.T2555M			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6170					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GTGTTGTACACGAGTGCCAAA	0.527000													21	22					0	0	1	0	0
CD86	942	broad.mit.edu	37	3	121828160	121828160	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:121828160C>T	ENST00000330540.2	+	5	868	c.752C>T	c.(751-753)gCt>gTt	p.A251V	CD86_ENST00000393627.2_Missense_Mutation_p.A245V|CD86_ENST00000264468.5_Missense_Mutation_p.A38V|CD86_ENST00000469710.1_Missense_Mutation_p.A169V|CD86_ENST00000493101.1_Missense_Mutation_p.A139V	NM_175862.4	NP_787058.4	P42081	CD86_HUMAN	CD86 molecule	251					interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	TGGATTACAGCTGTACTTCCA	0.423000													17	67					0	0	1	0	0
DNM1P46	0	broad.mit.edu	37	15	100340319	100340319	+	RNA	SNP	G	G	A	rs28696056		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:100340319G>A	ENST00000341853.1	-	0	607					NR_003260.1																						GTTCCCAAGCGAGTGCAGGTT	0.617000													10	18					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	129202690	129202690	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:129202690G>A	ENST00000280333.6	+	40	4165	c.4056G>A	c.(4054-4056)ctG>ctA	p.L1352L		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1352	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CCACATTCCTGCGGGTAAAGT	0.498000													5	8					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287735	16287735	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:16287735C>T	ENST00000343518.6	-	1	202	c.151G>A	c.(151-153)Gat>Aat	p.D51N		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	51										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						ATAGCAGAATCGTCGTGGTCT	0.602000													43	210					0	0	1	0	0
PSMA1	5682	broad.mit.edu	37	11	14539500	14539500	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:14539500T>C	ENST00000396394.2	-	3	472	c.76A>G	c.(76-78)Atg>Gtg	p.M26V	PSMA1_ENST00000555531.1_Missense_Mutation_p.M26V|PSMA1_ENST00000418988.2_Missense_Mutation_p.M32V|PSMA1_ENST00000396393.1_Missense_Mutation_p.M26V|PSMA1_ENST00000419365.2_Missense_Mutation_p.M26V|PSMA1_ENST00000530457.1_Start_Codon_SNP_p.M1V	NM_002786.3	NP_002777.1	P25786	PSA1_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 1	26					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	3						ACAGCTTCCATTGCATATTCA	0.299000													11	41					0	0	1	0	0
LRRC2	79442	broad.mit.edu	37	3	46592981	46592981	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:46592981C>A	ENST00000395905.3	-	2	493	c.101G>T	c.(100-102)aGg>aTg	p.R34M	LRRC2_ENST00000296144.3_Missense_Mutation_p.R34M|LRRC2_ENST00000496388.1_Intron	NM_024512.4	NP_078788.2	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	34										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	17		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		CTTCTCAAGCCTTTCCACCTC	0.463000													21	38					3.62473e-10	3.8659e-10	1	1	0
GBP6	163351	broad.mit.edu	37	1	89847452	89847452	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:89847452G>A	ENST00000370456.4	+	7	1164	c.1071G>A	c.(1069-1071)gcG>gcA	p.A357A	GBP6_ENST00000535065.1_Silent_p.A227A	NM_198460.2	NP_940862.2	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	357							GTP binding|GTPase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		ACATGCATGCGGCCTGTGAGA	0.537000													9	38					0	0	1	0	0
REEP3	221035	broad.mit.edu	37	10	65379471	65379471	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:65379471C>T	ENST00000373758.4	+	7	805	c.622C>T	c.(622-624)Cca>Tca	p.P208S	REEP3_ENST00000298249.4_Missense_Mutation_p.P193S	NM_001001330.2	NP_001001330.1	Q6NUK4	REEP3_HUMAN	receptor accessory protein 3	208						integral to membrane				endometrium(1)|large_intestine(2)|lung(3)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGCAGAGGGGCCATATTCAGA	0.413000													4	7					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88484886	88484886	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:88484886G>A	ENST00000324166.5	+	7	2808	c.1117G>A	c.(1117-1119)Gcc>Acc	p.A373T	THNSL2_ENST00000402102.1_Intron|THNSL2_ENST00000358591.2_Missense_Mutation_p.A373T|THNSL2_ENST00000343544.4_Intron|THNSL2_ENST00000449349.1_Intron|THNSL2_ENST00000496844.1_Intron|THNSL2_ENST00000377254.3_Intron	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	373					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						GTCGGATGAAGCCATCACCCA	0.562000													14	19					0	0	1	0	0
IRGQ	126298	broad.mit.edu	37	19	44096981	44096981	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44096981C>T	ENST00000422989.1	-	3	1224	c.1069G>A	c.(1069-1071)Gca>Aca	p.A357T	IRGQ_ENST00000602269.1_Missense_Mutation_p.A357T|IRGQ_ENST00000601520.1_5'UTR|L34079.2_ENST00000594374.1_Intron	NM_001007561.2	NP_001007562.1	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	357							protein binding			endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(3)	18		Prostate(69;0.0199)				CCTCCACCTGCGTTCTTTAAG	0.592000													28	69					0	0	1	0	0
IFRD1	3475	broad.mit.edu	37	7	112098937	112098937	+	Missense_Mutation	SNP	C	C	T	rs11542463		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:112098937C>T	ENST00000403825.3	+	5	692	c.431C>T	c.(430-432)gCa>gTa	p.A144V	IFRD1_ENST00000005558.4_Missense_Mutation_p.A144V|IFRD1_ENST00000535603.1_Missense_Mutation_p.A94V|IFRD1_ENST00000486688.1_3'UTR	NM_001550.3	NP_001541.2	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	144	Poly-Ala.				multicellular organismal development|myoblast cell fate determination		binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|urinary_tract(1)	15						GAGCAACGTGCAGCTGCAGCG	0.388000													6	38					0	0	1	0	0
OR7G1	125962	broad.mit.edu	37	19	9226080	9226080	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9226080G>A	ENST00000293614.1	-	1	359	c.360C>T	c.(358-360)taC>taT	p.Y120Y	OR7G1_ENST00000541538.1_Silent_p.Y120Y			Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G, member 1	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	20						CATAGCGGTCGTAGGCCATGA	0.488000													36	44					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161134081	161134081	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:161134081C>T	ENST00000308192.9	+	5	534	c.471C>T	c.(469-471)aaC>aaT	p.N157N	PLG_ENST00000462918.1_3'UTR	NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	157	Kringle 1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATCCAGACAACGATCCGCAGG	0.483000													37	62					0	0	1	0	0
SVOPL	136306	broad.mit.edu	37	7	138305867	138305867	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:138305867G>A	ENST00000421622.1	-	10	1125	c.917C>T	c.(916-918)aCg>aTg	p.T306M	SVOPL_ENST00000288513.5_Missense_Mutation_p.T274M|SVOPL_ENST00000463557.1_Intron|SVOPL_ENST00000419765.3_Missense_Mutation_p.T426M|SVOPL_ENST00000436657.1_Missense_Mutation_p.T274M			Q8N434	SVOPL_HUMAN	SVOP-like	426						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						AGCGCGCATCGTGGTGGGGTA	0.597000													5	21					0	0	1	0	0
FNIP1	96459	broad.mit.edu	37	5	131052273	131052273	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:131052273G>A	ENST00000307968.7	-	6	606	c.607C>T	c.(607-609)Ctg>Ttg	p.L203L	FNIP1_ENST00000510461.1_Silent_p.L203L|FNIP1_ENST00000514667.1_Intron|FNIP1_ENST00000511848.1_Silent_p.L203L|FNIP1_ENST00000307954.8_Silent_p.L158L	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TTTCCAAGCAGTCCATTAATA	0.308000													6	32					0	0	1	0	0
PCDHA2	0	broad.mit.edu	37	5	140176054	140176054	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140176054G>A	ENST00000526136.1	+	1	1505	c.1505G>A	c.(1504-1506)cGc>cAc	p.R502H	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.R502H|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.R502H	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGGCGAGCGCGCGTTGTCG	0.682000													12	51					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90159576	90159576	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:90159576C>A	ENST00000405460.2	+	83	17854	c.17758C>A	c.(17758-17760)Ctt>Att	p.L5920I	GPR98_ENST00000425867.2_Missense_Mutation_p.L1581I	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5920					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCCTACAGGTCTTTGCTTGGC	0.443000													27	44					2.44723e-14	2.66926e-14	1	1	0
MAP2K7	5609	broad.mit.edu	37	19	7975010	7975010	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7975010G>A	ENST00000545011.1	+	3	394	c.329G>A	c.(328-330)gGc>gAc	p.G110D	MAP2K7_ENST00000397981.3_Missense_Mutation_p.G110D|MAP2K7_ENST00000397983.3_Missense_Mutation_p.G126D|MAP2K7_ENST00000397979.3_Missense_Mutation_p.G110D			O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	110					activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.Q111fs*39(1)		breast(2)|central_nervous_system(3)|endometrium(1)|large_intestine(8)|lung(4)|ovary(1)	19					Etoposide(DB00773)	ACCATCGGGGGCCAGGTACCA	0.667000													3	14					0	0	1	0	0
ENTHD2	146705	broad.mit.edu	37	17	79204366	79204366	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79204366G>T	ENST00000374769.2	-	12	1232	c.755C>A	c.(754-756)cCt>cAt	p.P252H	AC027601.1_ENST00000569559.1_RNA|AC027601.1_ENST00000575922.1_RNA|ENTHD2_ENST00000300714.3_Missense_Mutation_p.P336H					ENTH domain containing 2																		GTTGGTCACAGGTCCCGGGCT	0.697000											OREG0024811	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	16					1.5739e-10	1.6844e-10	1	1	0
BAP1	8314	broad.mit.edu	37	3	52437772	52437772	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52437772C>T	ENST00000460680.1	-	13	1860	c.1389G>A	c.(1387-1389)ctG>ctA	p.L463L	BAP1_ENST00000296288.5_Silent_p.L445L	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	463					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		TCTTGATGGACAGAGGAATTG	0.592000			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							6	31					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27018008	27018008	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27018008C>T	ENST00000314616.6	+	27	3843	c.3560C>T	c.(3559-3561)gCg>gTg	p.A1187V	SUPT6H_ENST00000347486.4_Missense_Mutation_p.A1187V	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	1187					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					TATGACCAGGCGATCCGCAAT	0.552000													13	17					0	0	1	0	0
LRGUK	136332	broad.mit.edu	37	7	133932327	133932327	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:133932327G>T	ENST00000285928.2	+	17	2072	c.2003G>T	c.(2002-2004)aGa>aTa	p.R668I		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	668							ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						TCTATACACAGACAGCACGAG	0.373000													7	17					3.86212e-05	3.97146e-05	1	1	0
NOD1	10392	broad.mit.edu	37	7	30485797	30485797	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:30485797C>T	ENST00000222823.4	-	9	2938	c.2413G>A	c.(2413-2415)Gcc>Acc	p.A805T		NM_006092.2	NP_006083.1	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain containing 1	805					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity	p.A805T(1)		breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						ACAGCCAGGGCGAGATACTTC	0.522000													4	87					0	0	1	0	0
AEBP2	121536	broad.mit.edu	37	12	19653146	19653146	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:19653146T>C	ENST00000266508.9	+	5	1291	c.1290T>C	c.(1288-1290)ttT>ttC	p.F430F	AEBP2_ENST00000541908.1_Silent_p.F201F|AEBP2_ENST00000398864.3_Silent_p.F430F|AEBP2_ENST00000360995.4_Silent_p.F214F	NM_153207.4	NP_694939.2	Q6ZN18	AEBP2_HUMAN	AE binding protein 2	430	Interaction with SUZ12.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)|Esophageal squamous(101;0.143)					GTGTTGTTTTTCATAGTACTG	0.308000													4	7					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35647892	35647892	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:35647892C>T	ENST00000287272.2	+	16	2486	c.2466C>T	c.(2464-2466)ttC>ttT	p.F822F	UNC5D_ENST00000453357.2_Silent_p.F886F|UNC5D_ENST00000449677.1_Silent_p.F467F|UNC5D_ENST00000416672.1_Silent_p.F896F|UNC5D_ENST00000404895.2_Silent_p.F891F|UNC5D_ENST00000420357.1_Silent_p.F824F			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	891					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TATCTTATTTCGCTACACAAA	0.393000													5	69					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63444281	63444281	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:63444281C>T	ENST00000453546.1	-	11	2105	c.2016G>A	c.(2014-2016)caG>caA	p.Q672Q	ASB12_ENST00000396130.2_Silent_p.Q288Q|ASB12_ENST00000362002.2_Silent_p.Q297Q			Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	0						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						TGGCTTGTGGCTGGCCAGCCT	0.512000													16	23					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14778724	14778724	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:14778724C>A	ENST00000261170.3	-	21	2511	c.2375G>T	c.(2374-2376)aGg>aTg	p.R792M		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	792					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						TCTGTCAGCCCTGTCCCTCTC	0.448000													32	52					9.65021e-13	1.04556e-12	1	1	0
PRNP	5621	broad.mit.edu	37	20	4680520	4680520	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:4680520C>T	ENST00000379440.4	+	2	941	c.654C>T	c.(652-654)taC>taT	p.Y218Y	PRNP_ENST00000430350.2_Silent_p.Y218Y	NM_000311.3|NM_001080121.1|NM_001080122.1|NM_001080123.1|NM_001271561.1|NM_183079.2	NP_000302.1|NP_001073590.1|NP_001073591.1|NP_001073592.1|NP_001258490.1|NP_898902.1	P04156	PRIO_HUMAN	prion protein	218	Interaction with GRB2, ERI3 and SYN1 (By similarity).				axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	14					Tetracycline(DB00759)	TCACCCAGTACGAGAGGGAAT	0.532000													14	17					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73491778	73491778	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:73491778G>A	ENST00000224721.6	+	31	3770	c.3765G>A	c.(3763-3765)tcG>tcA	p.S1255S	C10orf105_ENST00000398786.2_Intron	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1250	Cadherin 12.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GCATCCTGTCGGGCGCAGAGG	0.552000													10	14					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48694698	48694698	+	Missense_Mutation	SNP	G	G	A	rs139931488	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48694698G>A	ENST00000544264.1	-	2	4112	c.3832C>T	c.(3832-3834)Cgc>Tgc	p.R1278C	CELSR3_ENST00000164024.4_Missense_Mutation_p.R1278C			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	1278					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TTCTCAAGGCGCACGGTCAGG	0.672000													5	9					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	56996954	56996954	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:56996954G>A	ENST00000200676.3	+	2	281	c.151G>A	c.(151-153)Gcc>Acc	p.A51T	CETP_ENST00000569082.1_3'UTR|CETP_ENST00000379780.2_Missense_Mutation_p.A51T|CETP_ENST00000566128.1_5'UTR	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	51					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						GATCCAGACCGCCTTCCAGCG	0.622000													12	13					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138655389	138655389	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:138655389C>T	ENST00000251691.4	+	33	5572	c.5406C>T	c.(5404-5406)ggC>ggT	p.G1802G		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	1802					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GCATCGGGGGCGCCGCCAACC	0.557000													4	7					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230705619	230705619	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:230705619C>T	ENST00000283943.5	-	4	1104	c.926G>A	c.(925-927)cGc>cAc	p.R309H	TRIP12_ENST00000409677.1_Missense_Mutation_p.R351H|TRIP12_ENST00000389045.3_Intron|TRIP12_ENST00000389044.4_Missense_Mutation_p.R351H|TRIP12_ENST00000543084.1_Intron	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	309					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		AGACTCACTGCGTTTCTTCGT	0.378000													13	16					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916935	178916935	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:178916935C>T	ENST00000263967.3	+	2	479	c.322C>T	c.(322-324)Cgt>Tgt	p.R108C		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	108	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G106_R108del(2)|p.G106_R108delGNR(2)|p.R108del(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGTAGGCAACCGTGAAGAAAA	0.338000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			21	38					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7748892	7748892	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7748892C>T	ENST00000254846.5	+	4	409	c.20C>T	c.(19-21)cCt>cTt	p.P7L	KDM6B_ENST00000448097.2_Missense_Mutation_p.P7L	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	7					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						GCAGTGGACCCTCCAGGGGCC	0.637000													31	60					0	0	1	0	0
EEA1	8411	broad.mit.edu	37	12	93221731	93221731	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:93221731T>C	ENST00000322349.8	-	12	1625	c.1361A>G	c.(1360-1362)cAa>cGa	p.Q454R		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	454	Gln/Glu/Lys-rich.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						ATCAGCCACTTGTTGTTCTTT	0.408000													44	57					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133783834	133783834	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:133783834G>A	ENST00000367895.5	+	9	1120	c.656G>A	c.(655-657)tGc>tAc	p.C219Y	EYA4_ENST00000531901.1_Missense_Mutation_p.C219Y|EYA4_ENST00000355286.6_Missense_Mutation_p.C196Y|EYA4_ENST00000430974.2_Missense_Mutation_p.C165Y|EYA4_ENST00000355167.3_Missense_Mutation_p.C219Y|EYA4_ENST00000525849.1_Missense_Mutation_p.C196Y|EYA4_ENST00000431403.2_Missense_Mutation_p.C219Y|EYA4_ENST00000452339.2_Missense_Mutation_p.C165Y	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	219					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CAGAGTGGCTGCCTCAGTTAC	0.468000													22	37					0	0	1	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839365	100839365	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100839365G>A	ENST00000440203.2	-	6	1031	c.974C>T	c.(973-975)cCg>cTg	p.P325L	MOGAT3_ENST00000379423.3_Missense_Mutation_p.R229C|MOGAT3_ENST00000223114.4_Silent_p.P296P			Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	0					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					GCTGGGGGACGGGGATGGGGC	0.672000													8	8					0	0	1	0	0
OPN3	23596	broad.mit.edu	37	1	241767744	241767744	+	Missense_Mutation	SNP	C	C	A	rs138070733		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:241767744C>A	ENST00000366554.2	-	2	617	c.511G>T	c.(511-513)Gca>Tca	p.A171S	OPN3_ENST00000469376.1_5'UTR|OPN3_ENST00000331838.5_Intron	NM_014322.2	NP_055137.2	Q9H1Y3	OPN3_HUMAN	opsin 3	171					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|visual perception	integral to plasma membrane	G-protein coupled photoreceptor activity			endometrium(1)|large_intestine(5)|lung(5)	11	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			AGGAGAGGTGCTCCTGCCCAC	0.542000													15	21					1.5739e-10	1.6844e-10	1	1	0
KIAA1324	57535	broad.mit.edu	37	1	109714585	109714585	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109714585G>A	ENST00000369939.3	+	4	748	c.565G>A	c.(565-567)Gtt>Att	p.V189I	KIAA1324_ENST00000529753.1_Missense_Mutation_p.V189I	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	189					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		ATCTGGCACCGTTAACTTCGA	0.547000													37	52					0	0	1	0	0
PHF15	0	broad.mit.edu	37	5	133914504	133914504	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:133914504G>A	ENST00000395003.1	+	11	2049	c.1870G>A	c.(1870-1872)Gcc>Acc	p.A624T	PHF15_ENST00000402835.1_3'UTR|PHF15_ENST00000282605.4_Missense_Mutation_p.A668T|PHF15_ENST00000361895.2_Missense_Mutation_p.A625T	NM_015288.4	NP_056103.4	Q9NQC1	JADE2_HUMAN		624	Pro-rich.				histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCCAGACAAAGCCCCCAAGAA	0.647000													13	18					0	0	1	0	0
CDKL5	6792	broad.mit.edu	37	X	18627658	18627658	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:18627658C>A	ENST00000379989.3	+	15	2405	c.2120C>A	c.(2119-2121)cCt>cAt	p.P707H	CDKL5_ENST00000463994.1_3'UTR|CDKL5_ENST00000379996.3_Missense_Mutation_p.P707H	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	707					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					TACAATGATCCTGTGCCAAGG	0.483000													38	11					1.04594e-18	1.1551e-18	1	1	0
POLR3B	55703	broad.mit.edu	37	12	106857351	106857351	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:106857351G>A	ENST00000228347.4	+	23	2888	c.2666G>A	c.(2665-2667)aGg>aAg	p.R889K	POLR3B_ENST00000539066.1_Missense_Mutation_p.R831K	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	889					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						AGACAGACAAGGCGTCCAGAA	0.358000													18	43					0	0	1	0	0
CXCL10	3627	broad.mit.edu	37	4	76943936	76943936	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:76943936G>A	ENST00000306602.1	-	2	161	c.96C>T	c.(94-96)tgC>tgT	p.C32C	ART3_ENST00000341029.5_Intron	NM_001565.3	NP_001556.2	P02778	CXL10_HUMAN	chemokine (C-X-C motif) ligand 10	32					blood circulation|cell surface receptor linked signaling pathway|cell-cell signaling|chemotaxis|inflammatory response|muscle organ development|positive regulation of cell proliferation	extracellular space	cAMP-dependent protein kinase regulator activity|chemokine activity			kidney(1)|large_intestine(1)|lung(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TAATGCTGATGCAGGTACAGC	0.398000													33	37					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70545919	70545919	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:70545919C>T	ENST00000265872.6	+	20	2796	c.2677C>T	c.(2677-2679)Cga>Tga	p.R893*	CCAR1_ENST00000543719.1_Nonsense_Mutation_p.R878*|CCAR1_ENST00000535016.1_Nonsense_Mutation_p.R878*	NM_018237.2	NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	893					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						AATGACCAAACGAGATGACAA	0.348000													7	15					0	0	1	0	0
ADARB2	105	broad.mit.edu	37	10	1263014	1263014	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:1263014C>T	ENST00000381312.1	-	7	1884	c.1559G>A	c.(1558-1560)cGc>cAc	p.R520H	ADARB2_ENST00000469464.1_5'UTR	NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	520	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GATCTTGGTGCGCAGGTGCCC	0.647000													4	3					0	0	1	0	0
SCYL1	57410	broad.mit.edu	37	11	65302765	65302765	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65302765C>T	ENST00000524944.1	+	10	1331	c.1298C>T	c.(1297-1299)gCa>gTa	p.A433V	SCYL1_ENST00000270176.5_Missense_Mutation_p.A433V|SCYL1_ENST00000533862.1_Missense_Mutation_p.A433V|SCYL1_ENST00000279270.6_Missense_Mutation_p.A433V|SCYL1_ENST00000527630.1_Missense_Mutation_p.A433V|SCYL1_ENST00000420247.2_Missense_Mutation_p.A433V|SCYL1_ENST00000527009.1_Missense_Mutation_p.A290V|SCYL1_ENST00000525364.1_Missense_Mutation_p.A433V			Q96KG9	NTKL_HUMAN	SCY1-like 1 (S. cerevisiae)	433					regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			ovary(1)|skin(1)	2						AAGCACTTTGCACGGCTACAG	0.582000													7	56					0	0	1	0	0
KCMF1	56888	broad.mit.edu	37	2	85273242	85273242	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:85273242G>A	ENST00000409785.3	+	5	801	c.442G>A	c.(442-444)Gtt>Att	p.V148I		NM_020122.4	NP_064507.3	Q9P0J7	KCMF1_HUMAN	potassium channel modulatory factor 1	148						intracellular	ligase activity|zinc ion binding			ovary(3)	3						ATCGAGTGGTGTTCGACATGT	0.413000													6	19					0	0	1	0	0
OR1L6	392390	broad.mit.edu	37	9	125512085	125512085	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:125512085C>A	ENST00000373684.1	+	1	67	c.67C>A	c.(67-69)Ctc>Atc	p.L23I				Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						CTTTACATCTCTCCCACTGCT	0.448000													42	52					2.215e-12	2.39657e-12	1	1	0
MAB21L1	4081	broad.mit.edu	37	13	36049680	36049680	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:36049680C>T	ENST00000379919.4	-	1	1152	c.596G>A	c.(595-597)cGg>cAg	p.R199Q	NBEA_ENST00000310336.4_Intron|NBEA_ENST00000379939.2_Intron|NBEA_ENST00000400445.3_Intron|NBEA_ENST00000540320.1_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	199					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		CTCCGCCACCCGGTTGGGTCC	0.647000													20	45					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60069953	60069953	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:60069953G>A	ENST00000267484.5	-	7	2541	c.2206C>T	c.(2206-2208)Cct>Tct	p.P736S	RTN1_ENST00000557422.1_5'UTR|RTN1_ENST00000342503.4_Missense_Mutation_p.P168S|RTN1_ENST00000395090.1_Missense_Mutation_p.P153S	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	736	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity	p.P736S(1)		central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TACACTACAGGTAGAGTAAAC	0.303000													28	39					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158283926	158283926	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:158283926C>T	ENST00000264192.3	-	6	604	c.483G>A	c.(481-483)gaG>gaA	p.E161E	CYTIP_ENST00000540637.1_Silent_p.E55E	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	161	PDZ.				regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						CATTAAGAGTCTCTATCCTGT	0.353000													7	13					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16259662	16259662	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:16259662C>T	ENST00000205557.7	-	23	3153	c.3124G>A	c.(3124-3126)Ggt>Agt	p.G1042S		NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	1042	ABC transmembrane type-1 2.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		AGCAGGTGACCAATGGGTGTC	0.582000													9	38					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158670285	158670285	+	Missense_Mutation	SNP	G	G	A	rs147682709	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158670285G>A	ENST00000359610.2	-	1	201	c.158C>T	c.(157-159)aCt>aTt	p.T53I		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					GTGGAGGTGAGTATTCAACTG	0.443000													14	22					0	0	1	0	0
APEH	327	broad.mit.edu	37	3	49720516	49720516	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49720516G>A	ENST00000296456.5	+	21	2430	c.2030G>A	c.(2029-2031)cGt>cAt	p.R677H	APEH_ENST00000438011.1_Missense_Mutation_p.R682H	NM_001640.3	NP_001631.3	P13798	ACPH_HUMAN	acylaminoacyl-peptide hydrolase	677					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|stomach(2)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GAGGACCGGCGTGTGCCCTTC	0.597000													4	12					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103908197	103908197	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:103908197C>T	ENST00000278070.2	+	10	4508	c.4469C>T	c.(4468-4470)tCg>tTg	p.S1490L	PPRC1_ENST00000489648.1_3'UTR|PPRC1_ENST00000370012.1_Missense_Mutation_p.S457L|PPRC1_ENST00000413464.2_Missense_Mutation_p.S1226L	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1490	Arg-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		tcttcctcttcgtcttcctca	0.557000													23	33					0	0	1	0	0
AHCY	191	broad.mit.edu	37	20	32873427	32873427	+	Missense_Mutation	SNP	C	C	T	rs116262714	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:32873427C>T	ENST00000538132.1	-	9	1288	c.902G>A	c.(901-903)cGg>cAg	p.R301Q	AHCY_ENST00000217426.2_Missense_Mutation_p.R329Q	NM_001161766.1	NP_001155238.1	P23526	SAHH_HUMAN	adenosylhomocysteinase	329					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding			endometrium(6)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						ATTCTTCAACCGATACCGGTC	0.637000													9	19					0	0	1	0	0
DSCR10	0	broad.mit.edu	37	21	39580630	39580630	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:39580630G>T	ENST00000432141.1	+	0	752					NR_027695.1																						AAACATCAAAGGTTCAAAAAA	0.284000													19	7					1.67942e-08	1.77343e-08	1	1	0
PPIL4	85313	broad.mit.edu	37	6	149833429	149833429	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:149833429G>A	ENST00000340881.2	-	0	520				PPIL4_ENST00000253329.2_Silent_p.Y363Y			Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 4						protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding			endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	13		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		ATATAAGATCGTATTTTGTAC	0.348000													5	83					0	0	1	0	0
SCP2	6342	broad.mit.edu	37	1	53444040	53444040	+	Splice_Site	SNP	G	G	A	rs144132787		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:53444040G>A	ENST00000371514.3	+	9	993		c.e9+1		SCP2_ENST00000473584.1_Splice_Site|SCP2_ENST00000371513.5_Splice_Site|SCP2_ENST00000371509.4_Splice_Site|SCP2_ENST00000528311.1_Splice_Site|SCP2_ENST00000407246.2_Splice_Site	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2						bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						TATTAAAATGGTATGTCTGAG	0.313000													20	26					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156506973	156506973	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156506973G>A	ENST00000361170.2	-	27	3432	c.3422_splice	c.e27+1	p.P1141_splice	IQGAP3_ENST00000498755.1_5'UTR	NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1141	Ras-GAP.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity	p.P1141Q(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTGCACATACGGAATTTGGTC	0.582000													31	40					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	656356	656356	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:656356G>A	ENST00000255622.6	+	14	1824	c.1781G>A	c.(1780-1782)gGc>gAc	p.G594D	PDE6B_ENST00000496514.1_Missense_Mutation_p.G594D|PDE6B_ENST00000429163.2_Missense_Mutation_p.G315D	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	594					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						GTGACAGCCGGCCTGTGCCAT	0.592000													6	24					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64121263	64121263	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64121263C>T	ENST00000356786.5	+	23	3954	c.3910C>T	c.(3910-3912)Cct>Tct	p.P1304S	CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000359902.2_Missense_Mutation_p.P456S|CCDC88B_ENST00000301897.4_Silent_p.S22S	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	1304					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CGTGCTGGAGCCTGTGCCCCT	0.647000													23	33					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152082617	152082617	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:152082617G>A	ENST00000368804.1	-	2	3075	c.3076C>T	c.(3076-3078)Ctg>Ttg	p.L1026L		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1026	10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGCTGCAGCTCGTCTTTT	0.577000													42	90					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57809088	57809088	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:57809088C>T	ENST00000281282.5	+	9	2592	c.2514C>T	c.(2512-2514)agC>agT	p.S838S		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	838						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGGGAAGAAGCGAAGAGCTGG	0.552000													10	11					0	0	1	0	0
SSH3	54961	broad.mit.edu	37	11	67072437	67072437	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67072437C>A	ENST00000308127.4	+	3	476	c.298C>A	c.(298-300)Ctc>Atc	p.L100I	SSH3_ENST00000376757.5_Missense_Mutation_p.L100I|SSH3_ENST00000308298.7_Missense_Mutation_p.L100I|SSH3_ENST00000532181.1_3'UTR	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3	100					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCACCTGCACCTCATGGTACA	0.652000													5	18					8.12818e-05	8.34155e-05	1	1	0
C8A	731	broad.mit.edu	37	1	57341738	57341738	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:57341738G>A	ENST00000361249.3	+	4	416	c.320G>A	c.(319-321)cGc>cAc	p.R107H		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	107	LDL-receptor class A.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						TCTCCAGGTCGCTGCCTGAAA	0.537000													9	10					0	0	1	0	0
TFCP2	7024	broad.mit.edu	37	12	51495718	51495718	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:51495718C>T	ENST00000307660.4	-	10	1718	c.998_splice	c.e10+1	p.R333_splice	TFCP2_ENST00000257915.5_Splice_Site_p.R384_splice|TFCP2_ENST00000548115.1_Splice_Site_p.R333_splice|TFCP2_ENST00000549867.1_Intron	NM_001173453.1	NP_001166924.1	Q12800	TFCP2_HUMAN	transcription factor CP2	384	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	23						AATTACATACCGGCCTTTTAA	0.358000													33	50					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140361841	140361841	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140361841G>T	ENST00000406427.1	-	26	3303	c.2967C>A	c.(2965-2967)gcC>gcA	p.A989A	PNPLA7_ENST00000277531.4_Silent_p.A964A|PNPLA7_ENST00000492278.1_5'UTR|PNPLA7_ENST00000371457.1_Silent_p.A570A	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	964	Patatin.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		CACCCACGAAGGCCCCGATGG	0.657000													6	27					0.00116845	0.0011864	1	1	0
PIWIL1	9271	broad.mit.edu	37	12	130827193	130827193	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:130827193G>A	ENST00000245255.3	+	2	329	c.57G>A	c.(55-57)gcG>gcA	p.A19A		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	19					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		AGGAGACAGCGCAGCTGGTGG	0.493000													8	10					0	0	1	0	0
IARS	3376	broad.mit.edu	37	9	95019010	95019010	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95019010G>T	ENST00000375643.3	-	20	2355	c.2089C>A	c.(2089-2091)Ctg>Atg	p.L697M	IARS_ENST00000447699.2_Missense_Mutation_p.L587M|IARS_ENST00000443024.2_Missense_Mutation_p.L697M|IARS_ENST00000375629.3_De_novo_Start_InFrame	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	697					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	ATGAAGGACAGGATCCACCGG	0.433000													22	29					5.35356e-11	5.74024e-11	1	1	0
OPRD1	4985	broad.mit.edu	37	1	29189256	29189256	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:29189256G>A	ENST00000234961.2	+	3	822	c.580G>A	c.(580-582)Ggg>Agg	p.G194R		NM_000911.3	NP_000902.3	P41143	OPRD_HUMAN	opioid receptor, delta 1	194					immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	CGGCCCAGACGGGGCAGTGGT	0.632000													8	15					0	0	1	0	0
STPG2	285555	broad.mit.edu	37	4	98762082	98762082	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:98762082A>G	ENST00000295268.3	-	9	1135	c.1044_splice	c.e9-1	p.V349_splice	STPG2_ENST00000506482.1_Intron	NM_174952.2	NP_777612.1			sperm-tail PG-rich repeat containing 2																		CGCTGGAATAACCTGAAAAAA	0.328000													26	40					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97167521	97167521	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:97167521C>T	ENST00000389672.5	+	7	1879	c.1841C>T	c.(1840-1842)gCg>gTg	p.A614V	EPHA6_ENST00000514100.1_5'UTR|EPHA6_ENST00000502694.1_5'UTR|EPHA6_ENST00000442602.2_5'UTR	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	519						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						GTGAGAACTGCGACAGGATAC	0.413000													17	32					0	0	1	0	0
ALKBH4	54784	broad.mit.edu	37	7	102100195	102100195	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:102100195C>T	ENST00000292566.3	-	2	216	c.177G>A	c.(175-177)gaG>gaA	p.E59E		NM_017621.3	NP_060091.1	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4 (E. coli)	59						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(1)|lung(5)|skin(2)	8						AGTCAGACTCCTCTGTGCCCA	0.577000													13	30					0	0	1	0	0
TMEM120A	83862	broad.mit.edu	37	7	75621505	75621505	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:75621505C>A	ENST00000338761.4	-	0	362				TMEM120A_ENST00000493111.2_RNA			Q9BXJ8	T120A_HUMAN	transmembrane protein 120A							integral to membrane											AAGAAGAGGCCTTGGCGCTCT	0.612000													31	27					6.00712e-18	6.62549e-18	1	1	0
RPGRIP1	57096	broad.mit.edu	37	14	21779073	21779073	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:21779073G>A	ENST00000206660.6	+	7	907	c.906_splice	c.e7-1	p.A303_splice	RPGRIP1_ENST00000557771.1_Intron|RPGRIP1_ENST00000556336.1_Intron|RPGRIP1_ENST00000400017.2_Intron			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	303					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TATTCTTCTAGCATGTGTGAG	0.368000													5	7					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121518996	121518996	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:121518996G>A	ENST00000305949.1	+	16	1823	c.1778G>A	c.(1777-1779)gGt>gAt	p.G593D		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	593	Interaction with MDM2 (By similarity).				cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			CACAAAGAGGGTCCTCGGGAC	0.403000													9	38					0	0	1	0	0
MFAP1	4236	broad.mit.edu	37	15	44107161	44107161	+	Missense_Mutation	SNP	C	C	A	rs114234191	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:44107161C>A	ENST00000267812.3	-	3	643	c.411G>T	c.(409-411)gaG>gaT	p.E137D		NM_005926.2	NP_005917.2	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	137	Poly-Glu.					microfibril				breast(2)|endometrium(1)|kidney(1)|lung(6)|skin(2)|upper_aerodigestive_tract(3)	15		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		CAATTTCCTCCTCCTCTTCTT	0.408000													31	72					9.65021e-13	1.04556e-12	1	1	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701610	56701610	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56701610G>A	ENST00000586855.2	-	5	1387	c.1074C>T	c.(1072-1074)gaC>gaT	p.D358D	ZSCAN5B_ENST00000358992.3_Silent_p.D358D			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	358					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TATTGCACACGTCACATGCAA	0.532000													24	35					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21030809	21030809	+	Silent	SNP	C	C	T	rs145036538		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:21030809C>T	ENST00000381545.3	+	10	1293	c.1074C>T	c.(1072-1074)taC>taT	p.Y358Y	LST3_ENST00000381541.3_Intron|LST3_ENST00000540229.1_Silent_p.Y358Y|SLCO1B3_ENST00000261196.2_Silent_p.Y358Y|SLCO1B3_ENST00000553473.1_Silent_p.Y358Y|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	358					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					CTTTTACTTACGTCTTTAAAT	0.338000													34	48					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61619769	61619769	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61619769C>T	ENST00000583023.1	+	9	2133	c.2122C>T	c.(2122-2124)Ctg>Ttg	p.L708L	KCNH6_ENST00000314672.5_Silent_p.L708L|KCNH6_ENST00000581784.1_Silent_p.L655L|KCNH6_ENST00000456941.2_Silent_p.L655L	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	708					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	CTGGAGTAAGCTGGAGGTCAC	0.642000													16	26					0	0	1	0	0
CPSF6	11052	broad.mit.edu	37	12	69653276	69653276	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:69653276C>A	ENST00000435070.2	+	7	1378	c.1268C>A	c.(1267-1269)gCa>gAa	p.A423E	CPSF6_ENST00000551516.1_Intron|CPSF6_ENST00000266679.8_Missense_Mutation_p.A460E|CPSF6_ENST00000456847.3_Missense_Mutation_p.A350E	NM_007007.2	NP_008938.2	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6, 68kDa	423					mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(7)|lung(8)	16	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			AGAAATAGGGCAATCTCAAGC	0.348000													22	42					3.62473e-10	3.8659e-10	1	1	0
DGCR8	54487	broad.mit.edu	37	22	20079068	20079068	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:20079068C>T	ENST00000351989.3	+	6	1846	c.1417C>T	c.(1417-1419)Cgg>Tgg	p.R473W	DGCR8_ENST00000383024.2_Missense_Mutation_p.R473W|DGCR8_ENST00000407755.1_Missense_Mutation_p.R473W	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	473	Necessary for heme-binding and pri-miRNA processing.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					GGAAATGAAGCGGAAGCAGGC	0.483000													30	126					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5319178	5319178	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:5319178C>G	ENST00000274181.7	+	23	3740	c.3602C>G	c.(3601-3603)cCc>cGc	p.P1201R		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	1201	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TACCTGGTACCCCAGCACGGG	0.537000													6	9					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4451274	4451274	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4451274G>A	ENST00000254718.4	-	13	2109	c.1803C>T	c.(1801-1803)ctC>ctT	p.L601L	MYBBP1A_ENST00000381556.2_Silent_p.L601L			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	601				L -> F (in Ref. 1; AAF33021).	nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						GGATGCCCACGAGGAGCAGAA	0.647000													3	4					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64085459	64085459	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:64085459G>A	ENST00000295902.6	-	8	2388	c.1803C>T	c.(1801-1803)agC>agT	p.S601S	RP11-129B22.1_ENST00000482609.1_RNA|PRICKLE2_ENST00000564377.1_Silent_p.S657S|PRICKLE2-AS1_ENST00000476308.1_RNA|PRICKLE2-AS1_ENST00000460946.1_RNA	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	601						cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CTGACTCTGCGCTCCGGAACT	0.552000													28	61					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6707910	6707910	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6707910C>T	ENST00000245907.6	-	15	1968	c.1876G>A	c.(1876-1878)Ggc>Agc	p.G626S		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	626					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GGGGTGCAGCCGATGTCTGCC	0.662000													19	38					0	0	1	0	0
PPP4R1	9989	broad.mit.edu	37	18	9588808	9588808	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:9588808G>A	ENST00000400556.3	-	5	412	c.339C>T	c.(337-339)atC>atT	p.I113I	RP11-881L2.1_ENST00000584109.1_RNA|PPP4R1_ENST00000580583.1_5'UTR|PPP4R1_ENST00000400555.3_Silent_p.I96I	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	113					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						AAAACAGTGCGATGTGAGGCA	0.413000													35	38					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11415435	11415435	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:11415435C>A	ENST00000423059.3	-	28	5211	c.4960G>T	c.(4960-4962)Gat>Tat	p.D1654Y	AC004538.3_ENST00000421121.1_RNA|AC004538.3_ENST00000599875.1_RNA|AC004538.3_ENST00000428967.1_RNA|AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1654						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ATGTCGGCATCTCCATCATAG	0.403000										HNSCC(18;0.044)			27	43					1.13719e-10	1.21767e-10	1	1	0
AP5Z1	9907	broad.mit.edu	37	7	4825902	4825902	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:4825902C>T	ENST00000348624.4	+	10	1248	c.1154C>T	c.(1153-1155)tCg>tTg	p.S385L	AP5Z1_ENST00000401897.1_Missense_Mutation_p.S385L	NM_014855.2	NP_055670.1	O43299	K0415_HUMAN	adaptor-related protein complex 5, zeta 1 subunit	385					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										GCAGTGGACTCGGAAGCCGTC	0.627000													15	16					0	0	1	0	0
CREM	1390	broad.mit.edu	37	10	35495960	35495960	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:35495960C>T	ENST00000333809.8	+	7	937	c.883C>T	c.(883-885)Ctg>Ttg	p.L295L	CREM_ENST00000345491.3_Silent_p.L246L|CREM_ENST00000474362.1_Silent_p.L42L|CREM_ENST00000473940.1_Silent_p.L67L|CREM_ENST00000344351.5_Silent_p.L42L|CREM_ENST00000479070.1_Silent_p.L258L|CREM_ENST00000374728.3_Silent_p.L167L|CREM_ENST00000374734.3_Silent_p.L183L|CREM_ENST00000374721.3_Silent_p.L216L|CREM_ENST00000490511.1_Silent_p.L59L|CREM_ENST00000361599.4_Silent_p.L216L|CREM_ENST00000468236.1_Silent_p.L71L|CREM_ENST00000342105.3_Silent_p.L191L|CREM_ENST00000463314.1_Silent_p.L84L|CREM_ENST00000474931.1_Silent_p.L59L|CREM_ENST00000488741.1_Silent_p.L49L|CREM_ENST00000488328.1_Silent_p.L55L|CREM_ENST00000460270.1_Silent_p.L42L|CREM_ENST00000487763.1_Silent_p.L67L|CREM_ENST00000484283.1_Silent_p.L165L|CREM_ENST00000439705.1_Silent_p.L232L|CREM_ENST00000429130.3_Silent_p.L291L|CREM_ENST00000395887.3_Silent_p.L228L|CREM_ENST00000356917.5_Silent_p.L55L|CREM_ENST00000395895.2_Silent_p.L307L|CREM_ENST00000337656.4_Silent_p.L246L|CREM_ENST00000354759.3_Silent_p.L195L|CREM_ENST00000463960.1_Silent_p.L140L|CREM_ENST00000348787.2_Silent_p.L167L	NM_183011.1	NP_898829.1	Q03060	CREM_HUMAN	cAMP responsive element modulator	307					cell differentiation|multicellular organismal development|signal transduction|spermatogenesis	nucleus	cAMP response element binding protein binding|protein binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14						CAAACGAGAGCTGAGGCTAAT	0.522000													24	38					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112770389	112770389	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:112770389C>T	ENST00000390666.3	-	1	339	c.148G>A	c.(148-150)Gca>Aca	p.A50T	CTD-2201G3.1_ENST00000416046.2_RNA|MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	50	Protein kinase.		A -> T.		cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.A50T(1)		large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		AAGAAGTCTGCGGGGGCCTTC	0.463000													10	25					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8230217	8230217	+	Silent	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:8230217G>C	ENST00000539824.1	+	12	2942	c.2568G>C	c.(2566-2568)ctG>ctC	p.L856L	SH3TC1_ENST00000245105.3_Silent_p.L932L			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	932							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						CCGTGCGGCTGTTCTCGAGGC	0.701000													11	18					0	0	1	0	0
AKIRIN2	55122	broad.mit.edu	37	6	88385621	88385621	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:88385621C>T	ENST00000257787.5	-	4	1082	c.558G>A	c.(556-558)acG>acA	p.T186T		NM_018064.3	NP_060534.1	Q53H80	AKIR2_HUMAN	akirin 2	186					innate immune response|transcription, DNA-dependent	transcriptional repressor complex				large_intestine(4)	4						TTTGATCATGCGTAAACTTCA	0.323000													14	71					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136298780	136298780	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136298780G>A	ENST00000371929.3	+	11	1708	c.1264G>A	c.(1264-1266)Gca>Aca	p.A422T	ADAMTS13_ENST00000356589.2_Missense_Mutation_p.A391T|ADAMTS13_ENST00000485925.1_Intron|ADAMTS13_ENST00000371916.1_3'UTR|ADAMTS13_ENST00000536611.1_Missense_Mutation_p.A94T|ADAMTS13_ENST00000355699.2_Missense_Mutation_p.A422T	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	422	TSP type-1 1.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		TGGGGGGCGTGCATGTGTTGG	0.622000													25	31					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678675	100678675	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100678675C>T	ENST00000306151.4	+	3	4042	c.3978C>T	c.(3976-3978)agC>agT	p.S1326S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1326	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AAGGTACCAGCATGCCAACCT	0.453000													71	117					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141799585	141799585	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:141799585C>T	ENST00000522684.1	-	14	1394	c.1165G>A	c.(1165-1167)Gtc>Atc	p.V389I	PTK2_ENST00000340930.3_Missense_Mutation_p.V389I|PTK2_ENST00000521059.1_Missense_Mutation_p.V389I|PTK2_ENST00000538769.1_Missense_Mutation_p.V50I|PTK2_ENST00000517887.1_Missense_Mutation_p.V433I|PTK2_ENST00000519419.1_Missense_Mutation_p.V433I|PTK2_ENST00000535192.1_Missense_Mutation_p.V389I|PTK2_ENST00000395218.2_Missense_Mutation_p.V389I	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	389					axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			GACACAGAGACGGCGTGTGTC	0.507000													6	167					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210559071	210559071	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:210559071C>A	ENST00000360351.4	+	7	2683	c.2177C>A	c.(2176-2178)cCt>cAt	p.P726H	MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.P722H|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000361559.4_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	726					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GATCTTTCTCCTCTGGCTTCC	0.463000													5	128					0.014758	0.0148771	1	1	0
ZNF91	7644	broad.mit.edu	37	19	23542635	23542635	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:23542635G>T	ENST00000300619.7	-	4	3351	c.3146C>A	c.(3145-3147)cCt>cAt	p.P1049H	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.P1017H	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	1049						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				ACACTTGTAAGGTTTCTCTCC	0.363000													25	47					1.42536e-11	1.5349e-11	1	1	0
PKDREJ	10343	broad.mit.edu	37	22	46657945	46657945	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:46657945G>A	ENST00000253255.5	-	1	1274	c.1275C>T	c.(1273-1275)ggC>ggT	p.G425G		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	425	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ACACGTGGTCGCCTTTAAGTG	0.532000													15	64					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94586597	94586597	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:94586597C>T	ENST00000370225.3	-	1	91	c.5G>A	c.(4-6)gGc>gAc	p.G2D	ABCA4_ENST00000535735.1_Missense_Mutation_p.G2D	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	2					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCTCACGAAGCCCATGCTAAT	0.512000													19	29					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9255853	9255853	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:9255853G>A	ENST00000383440.2	+	8	2776	c.2519G>A	c.(2518-2520)tGt>tAt	p.C840Y	ANKRD12_ENST00000400020.3_Missense_Mutation_p.C840Y|ANKRD12_ENST00000262126.3_Missense_Mutation_p.C863Y	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	863						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						CTTAGTGAATGTGTTGATAAA	0.303000													11	18					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139400023	139400023	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139400023G>A	ENST00000277541.6	-	25	4400	c.4325C>T	c.(4324-4326)cCg>cTg	p.P1442L		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1442					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GATCAGCGGCGGGGGGATGTC	0.677000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			7	18					0	0	1	0	0
PYCR2	29920	broad.mit.edu	37	1	226109966	226109966	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:226109966C>T	ENST00000343818.6	-	3	404	c.256G>A	c.(256-258)Gtg>Atg	p.V86M	RP4-559A3.7_ENST00000432920.2_Missense_Mutation_p.V86M|PYCR2_ENST00000478402.1_5'UTR	NM_013328.2	NP_037460.2	Q96C36	P5CR2_HUMAN	pyrroline-5-carboxylate reductase family, member 2	86					proline biosynthetic process	cytoplasm	binding|pyrroline-5-carboxylate reductase activity			kidney(1)|lung(3)	4	Breast(184;0.197)				L-Proline(DB00172)|NADH(DB00157)	CTGGCTTGCACGTCGGCCCCA	0.582000													7	18					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24580221	24580221	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:24580221C>T	ENST00000358321.3	+	4	818	c.557C>T	c.(556-558)tCg>tTg	p.S186L		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	186					immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						CATGTCAAGTCGCTGCCCACG	0.602000													4	20					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46937275	46937275	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:46937275G>A	ENST00000429979.1	-	6	1504	c.900C>T	c.(898-900)tgC>tgT	p.C300C	KIAA0226L_ENST00000389908.3_Silent_p.C300C|KIAA0226L_ENST00000378797.2_Silent_p.C300C|KIAA0226L_ENST00000378781.3_Silent_p.C300C|KIAA0226L_ENST00000409879.2_Silent_p.C143C|KIAA0226L_ENST00000322896.6_Silent_p.C143C|KIAA0226L_ENST00000378787.3_Silent_p.C300C|KIAA0226L_ENST00000534925.1_Silent_p.C165C|KIAA0226L_ENST00000378784.4_Silent_p.C233C	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	300										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						CATCAACATCGCATTTGCAAA	0.423000													11	15					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69341600	69341600	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:69341600C>T	ENST00000193403.6	-	21	3038	c.2655G>A	c.(2653-2655)gcG>gcA	p.A885A	ACTN1_ENST00000438964.2_Silent_p.A880A|ACTN1_ENST00000538545.2_Silent_p.A923A|ACTN1_ENST00000394419.4_Silent_p.A907A|ACTN1_ENST00000376839.3_Silent_p.A815A	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	885					focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CGCCGTACAGCGCCGTGGAGA	0.687000													13	23					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179486415	179486415	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179486415C>A	ENST00000589042.1	-	245	45360	c.45136G>T	c.(45136-45138)Gac>Tac	p.D15046Y	TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D6173Y|TTN_ENST00000591111.1_Missense_Mutation_p.D13405Y|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D5981Y|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D12478Y|TTN_ENST00000359218.5_Missense_Mutation_p.D6106Y|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13405	Fibronectin type-III 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTATAGTGTCTGTTTCACTA	0.368000													9	16					0.00448238	0.00453641	1	1	0
PLCH1	23007	broad.mit.edu	37	3	155232512	155232512	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:155232512C>A	ENST00000460012.1	-	12	1899	c.1542_splice	c.e12+1	p.Q514_splice	PLCH1_ENST00000494598.1_Splice_Site_p.Q532_splice|PLCH1_ENST00000447496.2_Splice_Site_p.Q532_splice|PLCH1_ENST00000414191.1_Splice_Site_p.Q514_splice|PLCH1_ENST00000340059.7_Splice_Site_p.Q532_splice|PLCH1_ENST00000334686.6_Splice_Site_p.Q514_splice			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	532					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AATCAGATACCTGCTTCAGGT	0.388000													18	37					1.33834e-09	1.42249e-09	1	1	0
IDE	3416	broad.mit.edu	37	10	94228698	94228698	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:94228698G>T	ENST00000265986.6	-	19	2314	c.2258C>A	c.(2257-2259)gCt>gAt	p.A753D	IDE_ENST00000496903.1_5'UTR|IDE_ENST00000371581.5_Missense_Mutation_p.A198D	NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	753					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTTGGTATGAGCATGTTCAAT	0.398000													14	18					3.52763e-06	3.66169e-06	1	1	0
RGS22	26166	broad.mit.edu	37	8	101020624	101020624	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:101020624C>T	ENST00000360863.6	-	15	2534	c.2340G>A	c.(2338-2340)tcG>tcA	p.S780S	RGS22_ENST00000523437.1_Silent_p.S768S|RGS22_ENST00000523287.1_Silent_p.S599S|RGS22_ENST00000519421.1_5'UTR	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	780					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CAATTTGGTCCGATTTTACCA	0.403000													24	61					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156521862	156521862	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156521862G>A	ENST00000361170.2	-	14	1484	c.1474C>T	c.(1474-1476)Cga>Tga	p.R492*		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	492					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGCTCCTGTCGCAATTTCAGC	0.552000													13	23					0	0	1	0	0
HEMGN	55363	broad.mit.edu	37	9	100693372	100693372	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:100693372G>A	ENST00000259456.3	-	4	448	c.305C>T	c.(304-306)gCa>gTa	p.A102V		NM_018437.3|NM_197978.2	NP_060907.2|NP_932095.1	Q9BXL5	HEMGN_HUMAN	hemogen	102					cell differentiation|multicellular organismal development					NS(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|skin(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(62;0.0559)				CTCTATAGGTGCCAGTGCTTT	0.443000													25	34					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55604636	55604636	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55604636C>T	ENST00000294383.6	-	25	2797	c.2798G>A	c.(2797-2799)cGc>cAc	p.R933H	USP24_ENST00000407756.1_Missense_Mutation_p.R773H	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	933					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						GATCACATAGCGCTCTGCCAG	0.368000													8	6					0	0	1	0	0
CAAP1	79886	broad.mit.edu	37	9	26842623	26842623	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:26842623T>C	ENST00000520187.1	-	2	413	c.326A>G	c.(325-327)tAc>tGc	p.Y109C	CAAP1_ENST00000535437.1_Silent_p.V109V|CAAP1_ENST00000333916.5_Silent_p.V254V			Q9H8G2	CI082_HUMAN	caspase activity and apoptosis inhibitor 1	0																	TTATACTGAGTACATCACTAT	0.403000													37	53					0	0	1	0	0
KLHL10	317719	broad.mit.edu	37	17	40001505	40001505	+	Missense_Mutation	SNP	T	T	C	rs141860514	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40001505T>C	ENST00000293303.4	+	3	965	c.812T>C	c.(811-813)aTg>aCg	p.M271T		NM_152467.3	NP_689680.2	Q6JEL2	KLH10_HUMAN	kelch-like family member 10	271						cytoplasm				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26		Breast(137;0.000162)				GACCTCAACATGAATGGACCC	0.463000													23	27					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41790016	41790016	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:41790016C>T	ENST00000396930.3	-	18	6265	c.5722G>A	c.(5722-5724)Gcc>Acc	p.A1908T	KAT6A_ENST00000265713.2_Missense_Mutation_p.A1908T|KAT6A_ENST00000406337.1_Missense_Mutation_p.A1908T	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1908	Met-rich.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding	p.A1908T(1)									ACATTATAGGCGGGAGTAGGC	0.517000													20	29					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	17952504	17952504	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:17952504G>A	ENST00000361221.3	+	14	1530	c.1371G>A	c.(1369-1371)aaG>aaA	p.K457K	ARHGEF10L_ENST00000375408.3_Silent_p.K235K|ARHGEF10L_ENST00000452522.1_Silent_p.K418K|ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000375420.3_Silent_p.K215K|ARHGEF10L_ENST00000375415.1_Silent_p.K418K|ARHGEF10L_ENST00000167825.4_Intron|ARHGEF10L_ENST00000434513.1_Silent_p.K457K	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	457	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		TGATGGTCAAGCCCATCCAGA	0.607000													15	34					0	0	1	0	0
DLL1	28514	broad.mit.edu	37	6	170592397	170592397	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:170592397G>A	ENST00000366756.3	-	9	2303	c.1970C>T	c.(1969-1971)gCg>gTg	p.A657V		NM_005618.3	NP_005609.3	O00548	DLL1_HUMAN	delta-like 1 (Drosophila)	657					cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			NS(2)|breast(1)|endometrium(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	33		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CTTGCTGTGCGCGTCCCTGAC	0.667000													13	19					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31567584	31567584	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:31567584C>T	ENST00000379416.3	-	31	3418	c.3370G>A	c.(3370-3372)Gac>Aac	p.D1124N		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	1124					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CTCACTGTGTCCATGTAGGCA	0.527000													7	24					0	0	1	0	0
PSIP1	11168	broad.mit.edu	37	9	15478515	15478515	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:15478515G>A	ENST00000380733.4	-	8	932	c.589C>T	c.(589-591)Ccc>Tcc	p.P197S	PSIP1_ENST00000380738.4_Missense_Mutation_p.P197S|PSIP1_ENST00000380716.4_Missense_Mutation_p.P197S|PSIP1_ENST00000380715.1_Missense_Mutation_p.P197S|PSIP1_ENST00000397519.2_Missense_Mutation_p.P197S			O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1	197					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(2)|endometrium(2)|kidney(1)|lung(3)|prostate(1)	9				GBM - Glioblastoma multiforme(50;2.38e-06)		ACCATTTTGGGTCTGCCTCTT	0.318000													60	79					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80044224	80044224	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80044224G>T	ENST00000306749.2	-	22	3856	c.3638C>A	c.(3637-3639)cCt>cAt	p.P1213H		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1213					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding	p.P1213L(1)		central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GCTGAGCAGAGGGTCCTCTGG	0.662000													7	9					3.09899e-07	3.24337e-07	1	1	0
COG2	22796	broad.mit.edu	37	1	230805102	230805102	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:230805102C>T	ENST00000534989.1	+	7	753	c.417_splice	c.e7-1	p.R140_splice	COG2_ENST00000494371.1_3'UTR|COG2_ENST00000535166.1_Splice_Site_p.R83_splice|COG2_ENST00000366668.3_Splice_Site_p.R199_splice|COG2_ENST00000366669.4_Splice_Site_p.R199_splice			Q14746	COG2_HUMAN	component of oligomeric golgi complex 2	199					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|urinary_tract(3)	27	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TTTCTTGCAGCGTATAGCTGG	0.418000													18	77					0	0	1	0	0
BFSP2	8419	broad.mit.edu	37	3	133119015	133119015	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:133119015C>T	ENST00000302334.2	+	1	177	c.88C>T	c.(88-90)Cca>Tca	p.P30S		NM_003571.2	NP_003562.1	Q13515	BFSP2_HUMAN	beaded filament structural protein 2, phakinin	30	Head.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						CTTCAGGGGGCCACGGTCATC	0.647000													13	22					0	0	1	0	0
C18orf25	147339	broad.mit.edu	37	18	43843064	43843064	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:43843064C>T	ENST00000282059.6	+	5	1569	c.1195C>T	c.(1195-1197)Cgt>Tgt	p.R399C	C18orf25_ENST00000321319.6_Missense_Mutation_p.R338C	NM_145055.3	NP_659492.1	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	399										central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						GGATAGCAGGCGTAAATACCT	0.473000													4	5					0	0	1	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555262	44555262	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:44555262C>T	ENST00000330682.2	-	1	1187	c.952G>A	c.(952-954)Gct>Act	p.A318T	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	318	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						GGCATCTTAGCGTTCACTCTG	0.652000													12	733					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124017682	124017682	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:124017682C>T	ENST00000360013.3	+	6	1135	c.1008C>T	c.(1006-1008)agC>agT	p.S336S	KALRN_ENST00000240874.3_Silent_p.S336S|KALRN_ENST00000460856.1_Silent_p.S336S	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	336					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TCCTCCAGAGCCACACGGAGA	0.512000													39	57					0	0	1	0	0
SCAP	22937	broad.mit.edu	37	3	47458688	47458688	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47458688C>T	ENST00000265565.5	-	18	3392	c.2980G>A	c.(2980-2982)Gcc>Acc	p.A994T	SCAP_ENST00000441517.2_Missense_Mutation_p.A738T|SCAP_ENST00000545718.1_Missense_Mutation_p.A601T	NM_012235.2	NP_036367.2	Q12770	SCAP_HUMAN	SREBF chaperone	994	Interaction with SREBF2 (By similarity).			A -> S (in Ref. 6; BAC11673).	cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		CCTTCAATGGCGTCCCACACC	0.637000													5	10					0	0	1	0	0
ANO6	196527	broad.mit.edu	37	12	45751119	45751119	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:45751119T>C	ENST00000320560.8	+	8	1112	c.910T>C	c.(910-912)Tat>Cat	p.Y304H	ANO6_ENST00000425752.2_Missense_Mutation_p.Y304H|ANO6_ENST00000441606.2_Missense_Mutation_p.Y286H|ANO6_ENST00000435642.1_Missense_Mutation_p.Y304H|ANO6_ENST00000426898.2_3'UTR|ANO6_ENST00000423947.3_Missense_Mutation_p.Y325H	NM_001025356.2	NP_001020527.2	Q4KMQ2	ANO6_HUMAN	anoctamin 6	304					activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						TTGGCTGGGCTATTACACTCA	0.393000													28	50					0	0	1	0	0
SRD5A2	6716	broad.mit.edu	37	2	31754466	31754466	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:31754466G>T	ENST00000405650.1	-	0	774				AL133247.2_ENST00000435713.1_RNA			P31213	S5A2_HUMAN	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)						androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity					Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	CCAGGGCATAGCCGATCCATT	0.473000													13	20					7.03913e-09	7.44699e-09	1	1	0
ATG9A	79065	broad.mit.edu	37	2	220091656	220091656	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:220091656G>A	ENST00000409618.1	-	5	587		c.e5-1		ATG9A_ENST00000361242.4_Splice_Site|ATG9A_ENST00000409422.1_Splice_Site|ATG9A_ENST00000488833.1_Splice_Site|ATG9A_ENST00000396761.2_Splice_Site			Q7Z3C6	ATG9A_HUMAN	autophagy related 9A						autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				endometrium(2)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(1)	13		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GATTATAAACGTGTAATTGTT	0.408000													13	32					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39052042	39052042	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39052042G>A	ENST00000355481.4	+	89	12688	c.12557G>A	c.(12556-12558)cGc>cAc	p.R4186H	RYR1_ENST00000360985.3_Missense_Mutation_p.R4186H|RYR1_ENST00000359596.3_Missense_Mutation_p.R4191H	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4191					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGCATCGAGCGCATCTACTTC	0.657000													15	19					0	0	1	0	0
RPGR	6103	broad.mit.edu	37	X	38182682	38182682	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:38182682A>G	ENST00000378505.2	-	2	300	c.124T>C	c.(124-126)Tgt>Cgt	p.C42R	RPGR_ENST00000309513.3_Missense_Mutation_p.C42R|RPGR_ENST00000342811.3_Missense_Mutation_p.C42R|RPGR_ENST00000339363.3_Missense_Mutation_p.C42R|TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000338898.3_Missense_Mutation_p.C42R|RPGR_ENST00000318842.7_Missense_Mutation_p.C42R	NM_001034853.1	NP_001030025.1	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	42					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						TCATCTCCACATGAAAGATGT	0.333000													3	24					0	0	1	0	0
ERAL1	26284	broad.mit.edu	37	17	27185652	27185652	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27185652G>A	ENST00000254928.5	+	7	867	c.770G>A	c.(769-771)gGt>gAt	p.G257D		NM_005702.2	NP_005693.1	O75616	ERAL1_HUMAN	Era-like 12S mitochondrial rRNA chaperone 1	257					ribosomal small subunit assembly	mitochondrial inner membrane|mitochondrial matrix	GTP binding|ribosomal small subunit binding|rRNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(2)	11	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.12e-05)|all cancers(11;5.32e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.105)			CTCACTGAAGGTGTGGTCAAT	0.542000													7	94					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53561001	53561001	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:53561001C>A	ENST00000342160.3	-	82	13446	c.12989G>T	c.(12988-12990)aGg>aTg	p.R4330M	HUWE1_ENST00000262854.6_Missense_Mutation_p.R4330M			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	4330	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						ATCTGTGGACCTGTCATCTCG	0.488000													22	4					9.04412e-07	9.43082e-07	1	1	0
FGF11	2256	broad.mit.edu	37	17	7346082	7346082	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7346082C>A	ENST00000575331.1	+	3	2350	c.206C>A	c.(205-207)gCt>gAt	p.A69D	RP11-104H15.7_ENST00000575310.1_RNA|FGF11_ENST00000293829.4_Missense_Mutation_p.A193D|FGF11_ENST00000572907.1_Missense_Mutation_p.A69D|RP11-104H15.8_ENST00000576615.1_RNA|FGF11_ENST00000575235.1_Missense_Mutation_p.A69D|FGF11_ENST00000575082.1_Missense_Mutation_p.A69D|FGF11_ENST00000575398.1_Missense_Mutation_p.A69D			Q92914	FGF11_HUMAN	fibroblast growth factor 11	193					cell-cell signaling|nervous system development|signal transduction		growth factor activity			central_nervous_system(1)|large_intestine(3)|ovary(1)|prostate(1)	6		Prostate(122;0.157)				ACCAAGGCAGCTGCCCACTTT	0.572000													36	56					2.09667e-21	2.32829e-21	1	1	0
OR2T12	127064	broad.mit.edu	37	1	248458392	248458392	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:248458392G>A	ENST00000317996.1	-	1	488	c.489C>T	c.(487-489)agC>agT	p.S163S		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			AATATGGGAAGCTCAGGGTAG	0.582000													22	28					0	0	1	0	0
RIPK1	8737	broad.mit.edu	37	6	3077075	3077075	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:3077075C>A	ENST00000259808.4	+	2	316	c.18C>A	c.(16-18)tcC>tcA	p.S6S	RIPK1_ENST00000541791.1_Silent_p.S6S|RIPK1_ENST00000380409.2_Silent_p.S6S|RIPK1_ENST00000479389.1_Intron			Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine kinase 1	6					activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				CAGACATGTCCTTGAATGTCA	0.488000													3	30					0.150653	0.151081	1	1	0
ABCA2	20	broad.mit.edu	37	9	139912118	139912118	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139912118G>A	ENST00000265662.5	-	17	2385	c.2238C>T	c.(2236-2238)aaC>aaT	p.N746N	ABCA2_ENST00000371605.3_Silent_p.N745N|ABCA2_ENST00000341511.6_Silent_p.N746N			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	745					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		AGTGCACCGCGTTGTTCAGGC	0.677000													10	26					0	0	1	0	0
PNMA1	9240	broad.mit.edu	37	14	74179676	74179676	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:74179676C>T	ENST00000316836.3	-	1	1452	c.667G>A	c.(667-669)Gcg>Acg	p.A223T		NM_006029.4	NP_006020.4	Q8ND90	PNMA1_HUMAN	paraneoplastic Ma antigen 1	223					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|urinary_tract(2)	13				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		gtggttatcgcggggttgttg	0.532000													41	64					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19967464	19967464	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19967464G>A	ENST00000263207.3	-	6	1489	c.1198C>T	c.(1198-1200)Cgg>Tgg	p.R400W	ARVCF_ENST00000344269.3_Missense_Mutation_p.R337W|ARVCF_ENST00000406522.1_Missense_Mutation_p.R337W|ARVCF_ENST00000406259.1_Missense_Mutation_p.R400W|ARVCF_ENST00000401994.1_Missense_Mutation_p.R337W	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	400					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					GGCAGCCCCCGCAACTGCCGT	0.697000													5	2					0	0	1	0	0
PYY	5697	broad.mit.edu	37	17	42030704	42030704	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42030704C>T	ENST00000360085.2	-	5	688	c.148G>A	c.(148-150)Gcc>Acc	p.A50T	PYY_ENST00000592796.1_Missense_Mutation_p.A50T	NM_004160.4	NP_004151.3	P10082	PYY_HUMAN	peptide YY	50					cell proliferation|cell-cell signaling|cellular component movement|cytoskeleton organization|digestion|G-protein coupled receptor protein signaling pathway	soluble fraction				endometrium(1)|ovary(1)	2		Breast(137;0.00314)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CGCAGGGAGGCGTAGTAGCGG	0.721000													6	13					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211298	78211298	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:78211298G>A	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TCCTGCTTGCGTAGCCTCTGC	0.572000													56	122					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17104395	17104395	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17104395A>G	ENST00000443236.1	-	12	1269	c.1236_splice	c.e12-1	p.V413_splice	CPAMD8_ENST00000388925.4_Splice_Site_p.V366_splice	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	366						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GGATAGCTCCACCTAGAAAAG	0.532000													5	27					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194167660	194167660	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:194167660T>C	ENST00000439040.1	-	14	2284	c.1493A>G	c.(1492-1494)gAc>gGc	p.D498G	ATP13A3_ENST00000256031.4_Missense_Mutation_p.D498G			Q9H7F0	AT133_HUMAN	ATPase type 13A3	498					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		ACCCACCTTGTCAAAGCAAAC	0.323000													4	83					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60757603	60757603	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:60757603G>A	ENST00000303375.5	+	15	2773	c.2371G>A	c.(2371-2373)Gcc>Acc	p.A791T		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	791	C-type lectin 4.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GCTGGACCTGGCCTCCCTGCA	0.652000													5	12					0	0	1	0	0
TBXA2R	0	broad.mit.edu	37	19	3600381	3600381	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3600381G>A	ENST00000375190.4	-	2	645	c.252C>T	c.(250-252)atC>atT	p.I84I	TBXA2R_ENST00000411851.3_Silent_p.I84I|TBXA2R_ENST00000589966.1_Silent_p.I84I	NM_001060.5|NM_201636.2	NP_001051.1|NP_963998.2	P21731	TA2R_HUMAN	thromboxane A2 receptor	84					platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	GGGACACCACGATGGTACCGG	0.672000													10	24					0	0	1	0	0
ZNF787	126208	broad.mit.edu	37	19	56600280	56600280	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56600280C>T	ENST00000270459.3	-	3	379	c.261G>A	c.(259-261)acG>acA	p.T87T		NM_001002836.2	NP_001002836.2	Q6DD87	ZN787_HUMAN	zinc finger protein 787	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|lung(2)|pancreas(1)	5		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0559)		CGCCGGTGTGCGTGCGCTGGT	0.716000													8	15					0	0	1	0	0
LAG3	3902	broad.mit.edu	37	12	6886984	6886984	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6886984G>A	ENST00000203629.2	+	7	1661	c.1328G>A	c.(1327-1329)gGt>gAt	p.G443D		NM_002286.5	NP_002277.4	P18627	LAG3_HUMAN	lymphocyte-activation gene 3	443						integral to membrane	antigen binding|MHC class II protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						AGAGCCCCAGGTGCCCTCCCA	0.527000													15	34					0	0	1	0	0
EIF5	1983	broad.mit.edu	37	14	103803076	103803076	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:103803076C>T	ENST00000216554.3	+	5	893	c.217C>T	c.(217-219)Cgt>Tgt	p.R73C	EIF5_ENST00000560200.1_3'UTR|EIF5_ENST00000392715.2_Missense_Mutation_p.R73C|EIF5_ENST00000558506.1_Missense_Mutation_p.R73C	NM_001969.4	NP_001960.2	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	73					regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			breast(3)|kidney(2)|large_intestine(3)|lung(5)|pancreas(2)|skin(2)|upper_aerodigestive_tract(1)	18		Melanoma(154;0.155)	Epithelial(46;0.182)			TAAGAATGACCGTTACATTGT	0.388000													30	50					0	0	1	0	0
APBB2	323	broad.mit.edu	37	4	41016017	41016017	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:41016017G>A	ENST00000295974.8	-	6	1047	c.418C>T	c.(418-420)Ccc>Tcc	p.P140S	APBB2_ENST00000508593.1_Missense_Mutation_p.P140S|APBB2_ENST00000513140.1_Missense_Mutation_p.P140S|APBB2_ENST00000506352.1_Missense_Mutation_p.P140S	NM_001166050.1|NM_004307.1	NP_001159522.1|NP_004298.1	Q92870	APBB2_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 2	140					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(3)|skin(2)|urinary_tract(1)	34						TGTGGGTGGGGCTCTTTACCC	0.517000													36	41					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21396450	21396450	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:21396450C>T	ENST00000313654.9	+	18	2387	c.2147_splice	c.e18+1	p.R716_splice	LAMA3_ENST00000399516.3_Splice_Site_p.R716_splice	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	716	Domain V.|Laminin EGF-like 8.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGTGCCAGCGGTGAGTCTT	0.572000													9	8					0	0	1	0	0
KIF3A	11127	broad.mit.edu	37	5	132056317	132056317	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:132056317C>T	ENST00000378746.4	-	5	818	c.600G>A	c.(598-600)acG>acA	p.T200T	KIF3A_ENST00000378735.1_Silent_p.T200T|KIF3A_ENST00000403231.1_Silent_p.T200T|AC004237.1_ENST00000431165.1_RNA	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	200	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGTGGCCTAGCGTCATAATTC	0.343000													24	47					0	0	1	0	0
RAET1L	154064	broad.mit.edu	37	6	150342136	150342136	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:150342136G>A	ENST00000367341.1	-	3	535	c.536C>T	c.(535-537)gCc>gTc	p.A179V	RAET1L_ENST00000286380.2_Missense_Mutation_p.A179V			Q5VY80	RET1L_HUMAN	retinoic acid early transcript 1L	179	MHC class I alpha-2 like (By similarity).				antigen processing and presentation|immune response	anchored to membrane|MHC class I protein complex				endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	5		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.4e-12)		GAAGGACATGGCCACATCCTT	0.493000													5	107					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74387399	74387399	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74387399C>T	ENST00000319380.7	-	18	3568	c.3504G>A	c.(3502-3504)tcG>tcA	p.S1168S		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	1168							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						GGGGCTCTGGCGAGCTGCTGG	0.667000													17	22					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061060	9061060	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9061060C>T	ENST00000397910.4	-	3	26589	c.26386G>A	c.(26386-26388)Gca>Aca	p.A8796T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8798	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGAGGATGCCCCAGAATGA	0.512000													14	60					0	0	1	0	0
SLC35E4	339665	broad.mit.edu	37	22	31033021	31033021	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31033021C>T	ENST00000343605.4	+	1	1383	c.584C>T	c.(583-585)gCc>gTc	p.A195V	SLC35E4_ENST00000406566.1_Missense_Mutation_p.A195V|SLC35E4_ENST00000300385.8_Missense_Mutation_p.A195V	NM_001001479.2	NP_001001479.1	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	195	Leu-rich.					integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	10						CTGCTCGCAGCCACCTGCCTC	0.667000													11	26					0	0	1	0	0
STXBP5	0	broad.mit.edu	37	6	147648402	147648402	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:147648402G>T	ENST00000367481.3	+	18	2178	c.2070G>T	c.(2068-2070)caG>caT	p.Q690H	STXBP5_ENST00000367480.3_Missense_Mutation_p.Q690H|STXBP5_ENST00000321680.6_Missense_Mutation_p.Q690H|STXBP5_ENST00000179882.6_Missense_Mutation_p.Q361H	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	690					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		AATCTCGACAGCCTTCAGGAG	0.383000													26	43					4.72057e-08	4.96844e-08	1	1	0
GPR179	440435	broad.mit.edu	37	17	36483525	36483525	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36483525C>T	ENST00000342292.4	-	11	5947	c.5927G>A	c.(5926-5928)cGc>cAc	p.R1976H	GPR179_ENST00000584976.1_Intron	NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	1976						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TTGGTCAGGGCGCTGTCTGTC	0.552000													8	20					0	0	1	0	0
PIK3R4	30849	broad.mit.edu	37	3	130463754	130463754	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:130463754C>T	ENST00000356763.3	-	2	866	c.309G>A	c.(307-309)agG>agA	p.R103R		NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	103	Protein kinase.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						GCACATACTGCCTAAAGAGCA	0.443000													32	55					0	0	1	0	0
STXBP5	0	broad.mit.edu	37	6	147637445	147637445	+	Silent	SNP	C	C	A	rs142531466		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:147637445C>A	ENST00000367481.3	+	16	1812	c.1704C>A	c.(1702-1704)ccC>ccA	p.P568P	STXBP5_ENST00000367480.3_Silent_p.P568P|STXBP5_ENST00000321680.6_Silent_p.P568P|STXBP5_ENST00000179882.6_Silent_p.P239P	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	568					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TGCCAACACCCGTGGGAGGGT	0.468000													16	20					2.23348e-06	2.32236e-06	1	1	0
IL1R2	7850	broad.mit.edu	37	2	102641024	102641024	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:102641024T>G	ENST00000332549.3	+	7	1010	c.781T>G	c.(781-783)Ttt>Gtt	p.F261V	IL1R2_ENST00000441002.1_Missense_Mutation_p.F261V|IL1R2_ENST00000393414.2_Missense_Mutation_p.F261V|IL1R2_ENST00000485335.1_3'UTR	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	261	Ig-like C2-type 3.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	GTGTAAGGTGTTTCTGGGAAC	0.612000													18	27					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158870174	158870174	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:158870174C>T	ENST00000367097.3	+	4	2047	c.690C>T	c.(688-690)agC>agT	p.S230S	TULP4_ENST00000367094.2_Silent_p.S230S	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	230					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GCAGCGAGAGCGACACGGACT	0.582000													18	27					0	0	1	0	0
FEM1C	56929	broad.mit.edu	37	5	114861010	114861010	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:114861010A>G	ENST00000274457.3	-	3	1410	c.849T>C	c.(847-849)atT>atC	p.I283I		NM_020177.2	NP_064562.1	Q96JP0	FEM1C_HUMAN	fem-1 homolog c (C. elegans)	283						cytoplasm				breast(5)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	18		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		GTTTACTAATAATATTAGTCC	0.393000													41	48					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152807870	152807870	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:152807870C>T	ENST00000370186.1	+	5	1080	c.754C>T	c.(754-756)Cgc>Tgc	p.R252C	ATP2B3_ENST00000370181.2_Missense_Mutation_p.R252C|ATP2B3_ENST00000263519.4_Missense_Mutation_p.R252C|ATP2B3_ENST00000393842.1_Missense_Mutation_p.R252C|ATP2B3_ENST00000349466.2_Missense_Mutation_p.R252C|ATP2B3_ENST00000359149.3_Missense_Mutation_p.R252C			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	252					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGACCACGTGCGCAAGTCAGC	0.657000													7	3					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21993740	21993740	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:21993740G>A	ENST00000327430.3	-	2	416	c.122C>T	c.(121-123)gCa>gTa	p.A41V	SALL2_ENST00000450879.2_Missense_Mutation_p.A39V|SALL2_ENST00000317492.5_Missense_Mutation_p.A41V|SALL2_ENST00000538754.1_Missense_Mutation_p.A39V	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	41							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		AGTGAATTGTGCGCAGCACTT	0.557000													20	36					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169578832	169578832	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:169578832G>A	ENST00000263686.6	-	8	1280	c.1243C>T	c.(1243-1245)Cgc>Tgc	p.R415C	SELP_ENST00000367788.2_Missense_Mutation_p.R353C|SELP_ENST00000367793.2_Missense_Mutation_p.R353C|SELP_ENST00000367794.2_Missense_Mutation_p.R353C|SELP_ENST00000367786.2_Missense_Mutation_p.R353C|SELP_ENST00000458599.2_Missense_Mutation_p.R353C|SELP_ENST00000367792.2_Missense_Mutation_p.R353C|SELP_ENST00000367791.2_Intron	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	415	Sushi 4.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TCAGCACAGCGGAAGCTACAG	0.517000													13	26					0	0	1	0	0
KIAA0753	9851	broad.mit.edu	37	17	6526296	6526296	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:6526296C>T	ENST00000361413.3	-	6	1368	c.1010G>A	c.(1009-1011)gGc>gAc	p.G337D	KIAA0753_ENST00000572370.1_Missense_Mutation_p.G38D|KIAA0753_ENST00000542606.1_Missense_Mutation_p.G38D	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	337						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		AATAAGGCTGCCCAGTTCCTT	0.507000													21	27					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42832599	42832599	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:42832599C>T	ENST00000314073.5	+	13	2831	c.2655C>T	c.(2653-2655)atC>atT	p.I885I	GLTSCR1L_ENST00000394168.1_Silent_p.I885I					GLTSCR1-like																		CTAATCACATCGTGGTCTCTG	0.498000													7	22					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61851610	61851610	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:61851610G>T	ENST00000577390.1	-	7	2004	c.1050C>A	c.(1048-1050)tcC>tcA	p.S350S	CDH8_ENST00000584337.1_Silent_p.S350S|CDH8_ENST00000299345.6_Silent_p.S350S|CDH8_ENST00000577730.1_Silent_p.S350S	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	350	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTAGCGTATAGGATTTTTTGG	0.443000													25	35					3.01185e-09	3.19065e-09	1	1	0
CCDC8	83987	broad.mit.edu	37	19	46915402	46915402	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46915402G>A	ENST00000307522.3	-	1	1439	c.666C>T	c.(664-666)ggC>ggT	p.G222G		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	222						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		GCCGGGCCTCGCCCACCCCGG	0.701000													8	4					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117374666	117374666	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:117374666C>T	ENST00000321322.6	-	11	2434	c.2433G>A	c.(2431-2433)tcG>tcA	p.S811S	DSCAML1_ENST00000527706.1_Silent_p.S541S	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	751	Ig-like C2-type 9.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GGATCAGCAGCGAGCTGTTGG	0.622000													23	24					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7644157	7644157	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7644157G>A	ENST00000572933.1	+	11	2996	c.1536G>A	c.(1534-1536)gcG>gcA	p.A512A	DNAH2_ENST00000082259.3_Silent_p.A594A|DNAH2_ENST00000570791.1_Silent_p.A594A|DNAH2_ENST00000389173.2_Silent_p.A512A			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	512	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACAAGAAGGCGGTGGATCTCT	0.582000													37	49					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033231	82033231	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:82033231C>T	ENST00000328945.5	-	3	794	c.667G>A	c.(667-669)Gtc>Atc	p.V223I		NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	223					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						TCCACGTGGACAAACTCAACC	0.542000													34	110					0	0	1	0	0
SH2D3A	10045	broad.mit.edu	37	19	6760867	6760867	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6760867C>T	ENST00000245908.6	-	3	470	c.201G>A	c.(199-201)ctG>ctA	p.L67L	SH2D3A_ENST00000599563.1_5'UTR|SH2D3A_ENST00000437152.3_Intron	NM_005490.2	NP_005481.2	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	67	SH2.				JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|urinary_tract(1)	24						GCCGGGGACGCAGGGCCACAC	0.642000													7	46					0	0	1	0	0
DIRAS3	9077	broad.mit.edu	37	1	68512685	68512685	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:68512685C>T	ENST00000370981.1	-	4	932	c.296G>A	c.(295-297)cGc>cAc	p.R99H	GNG12-AS1_ENST00000420587.1_RNA|GNG12-AS1_ENST00000413628.1_RNA|DIRAS3_ENST00000395201.1_Missense_Mutation_p.R99H			O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	99					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity	p.R99H(1)		NS(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						CTGCAGAGCGCGGTTGCCGTC	0.587000													35	57					0	0	1	0	0
ADAT3	113179	broad.mit.edu	37	19	1913103	1913103	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1913103C>T	ENST00000329478.2	+	2	1277	c.1057C>T	c.(1057-1059)Cgc>Tgc	p.R353C	ADAT3_ENST00000602400.1_Missense_Mutation_p.R337C|SCAMP4_ENST00000414057.2_Intron|SCAMP4_ENST00000409472.1_Intron|SCAMP4_ENST00000316097.8_Intron			Q96EY9	ADAT3_HUMAN	adenosine deaminase, tRNA-specific 3	337					tRNA processing		hydrolase activity|zinc ion binding			breast(1)|kidney(3)|pancreas(1)|skin(2)	7		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGGTGTTCCGCGGGGTGCT	0.751000													3	7					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34014941	34014941	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:34014941C>T	ENST00000389232.4	+	44	6715	c.6645C>T	c.(6643-6645)agC>agT	p.S2215S	RYR3_ENST00000415757.3_Silent_p.S2215S	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2215	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AAAACGCCAGCGTTGTGGTCA	0.557000													36	50					0	0	1	0	0
WDR77	79084	broad.mit.edu	37	1	111983960	111983960	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:111983960C>T	ENST00000235090.5	-	10	1127	c.921G>A	c.(919-921)ccG>ccA	p.P307P	WDR77_ENST00000411751.2_Silent_p.P243P|WDR77_ENST00000497278.1_5'UTR	NM_024102.2	NP_077007.1	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	307					ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGTGATTGAGCGGGGACCAAG	0.532000													18	26					0	0	1	0	0
CNTROB	116840	broad.mit.edu	37	17	7846781	7846781	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7846781C>T	ENST00000380262.3	+	10	2309	c.1384C>T	c.(1384-1386)Cgg>Tgg	p.R462W	CNTROB_ENST00000563694.1_Missense_Mutation_p.R462W|CNTROB_ENST00000565740.1_Missense_Mutation_p.R462W|CNTROB_ENST00000380255.3_Missense_Mutation_p.R462W	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	462	Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				GGTGACAGAGCGGCTGGCGCA	0.627000													16	11					0	0	1	0	0
PCP2	126006	broad.mit.edu	37	19	7697340	7697340	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7697340C>T	ENST00000311069.5	-	3	520	c.230G>A	c.(229-231)cGc>cAc	p.R77H	CTD-3214H19.4_ENST00000595866.1_Intron|PCP2_ENST00000598935.1_Missense_Mutation_p.R61H	NM_174895.1	NP_777555.1	Q8IVA1	PCP2_HUMAN	Purkinje cell protein 2	77	GoLoco 2.				signal transduction		GTPase activator activity			endometrium(1)|urinary_tract(1)	2						GTCATCCATGCGGCGGCCCTG	0.637000													26	49					0	0	1	0	0
WDR18	57418	broad.mit.edu	37	19	989795	989795	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:989795C>T	ENST00000251289.5	+	3	378	c.355C>T	c.(355-357)Cga>Tga	p.R119*	WDR18_ENST00000591997.1_3'UTR|WDR18_ENST00000587001.2_Nonsense_Mutation_p.R119*	NM_024100.3	NP_077005.2	Q9BV38	WDR18_HUMAN	WD repeat domain 18	119										endometrium(1)|kidney(2)|lung(2)|skin(2)	7		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CATCCTGAGTCGACACTACCA	0.622000													33	45					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154557442	154557442	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154557442C>T	ENST00000368474.4	-	15	3720	c.3521G>A	c.(3520-3522)cGc>cAc	p.R1174H	ADAR_ENST00000292205.5_Missense_Mutation_p.R1217H|ADAR_ENST00000368471.3_Missense_Mutation_p.R879H	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	1174	A to I editase.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TAGATCCCTGCGGTAACGGAA	0.473000													35	70					0	0	1	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105361634	105361634	+	Missense_Mutation	SNP	C	C	T	rs146710492	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:105361634C>T	ENST00000297581.2	+	2	903	c.854C>T	c.(853-855)cCg>cTg	p.P285L	DCSTAMP_ENST00000517991.1_Intron|DPYS_ENST00000521601.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	285					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											ACTTTCTGGCCGACTCCTAAA	0.478000													40	53					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64532491	64532491	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:64532491G>A	ENST00000498707.1	-	32	5349	c.5007C>T	c.(5005-5007)ccC>ccT	p.P1669P	ADAMTS9_ENST00000295903.4_Silent_p.P1641P	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1669	TSP type-1 14.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TCAGGTAACAGGGGTGAACAC	0.547000													23	30					0	0	1	0	0
ZNF30	90075	broad.mit.edu	37	19	35435549	35435549	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35435549G>A	ENST00000439785.1	+	5	2126	c.1682G>A	c.(1681-1683)aGt>aAt	p.S561N	ZNF30_ENST00000601142.1_Missense_Mutation_p.S560N|ZNF30_ENST00000426813.2_Missense_Mutation_p.S479N|ZNF30_ENST00000601957.1_3'UTR|ZNF30_ENST00000303586.7_Missense_Mutation_p.S561N	NM_001099438.1	NP_001092908.1	P17039	ZNF30_HUMAN	zinc finger protein 30	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)	16	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		GGACATCAGAGTGTTCACACT	0.413000													13	15					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10468707	10468707	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10468707G>A	ENST00000525621.1	-	16	2764	c.2283C>T	c.(2281-2283)ggC>ggT	p.G761G	TYK2_ENST00000264818.6_Silent_p.G761G|TYK2_ENST00000529370.1_Silent_p.G761G|TYK2_ENST00000524462.1_Silent_p.G576G	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	761	Protein kinase 1.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCAGGCCCACGCCAGGATCAC	0.642000													7	13					0	0	1	0	0
PLEKHA8	84725	broad.mit.edu	37	7	30094928	30094928	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:30094928G>A	ENST00000449726.1	+	9	1359	c.1009G>A	c.(1009-1011)Gca>Aca	p.A337T	PLEKHA8_ENST00000396257.2_Missense_Mutation_p.A337T|PLEKHA8_ENST00000396259.1_Missense_Mutation_p.A337T|PLEKHA8_ENST00000258679.7_Missense_Mutation_p.A337T	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	337					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						AGCATTCTTGGCATCATGTTA	0.393000													26	72					0	0	1	0	0
MAP4K5	11183	broad.mit.edu	37	14	50904244	50904244	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:50904244G>A	ENST00000013125.4	-	25	2150	c.1832C>T	c.(1831-1833)gCt>gTt	p.A611V		NM_006575.4|NM_198794.2	NP_006566.2|NP_942089.1	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase kinase 5	611	CNH.				activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_epithelial(31;0.000415)|Breast(41;0.0102)					TGTTGTTAAAGCGAATTTTCT	0.343000													4	6					0	0	1	0	0
REST	5978	broad.mit.edu	37	4	57796717	57796717	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:57796717G>T	ENST00000309042.7	+	4	2007	c.1693G>T	c.(1693-1695)Gtg>Ttg	p.V565L		NM_001193508.1|NM_005612.4	NP_001180437.1|NP_005603.3	Q13127	REST_HUMAN	RE1-silencing transcription factor	565	Lys-rich.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	50	Glioma(25;0.08)|all_neural(26;0.181)					TGACAGCAAAGTGGAGGAGAA	0.343000													13	13					1.05317e-09	1.12079e-09	1	1	0
VLDLR	7436	broad.mit.edu	37	9	2639945	2639945	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:2639945T>C	ENST00000382100.2	+	3	645	c.289T>C	c.(289-291)Tgc>Cgc	p.C97R	RP11-125B21.2_ENST00000599229.1_RNA|VLDLR_ENST00000382099.2_Missense_Mutation_p.C97R	NM_003383.3	NP_003374.3	P98155	VLDLR_HUMAN	very low density lipoprotein receptor	97	LDL-receptor class A 2.				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		AGATCCTGACTGCGAAGATGG	0.458000													48	65					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7188188	7188188	+	Missense_Mutation	SNP	G	G	A	rs144324520	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:7188188G>A	ENST00000486284.1	+	2	843	c.569G>A	c.(568-570)cGg>cAg	p.R190Q	GRM7_ENST00000402647.2_Missense_Mutation_p.R190Q|GRM7_ENST00000357716.4_Missense_Mutation_p.R190Q|GRM7_ENST00000403881.1_Missense_Mutation_p.R190Q|GRM7_ENST00000389336.4_Missense_Mutation_p.R190Q	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	190					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AGTGATGACCGGCGCTATGAC	0.527000													26	43					0	0	1	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148699201	148699201	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:148699201C>A	ENST00000296721.4	+	13	1634	c.1536C>A	c.(1534-1536)ggC>ggA	p.G512G	AFAP1L1_ENST00000515000.1_Silent_p.G512G	NM_001146337.1|NM_152406.2	NP_001139809.1|NP_689619.1	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	512	PH 2.						protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAGATGGGCTCCAGAGTCA	0.562000													7	23					1.12685e-05	1.16601e-05	1	1	0
NDUFA7	4701	broad.mit.edu	37	19	8381425	8381425	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8381425A>G	ENST00000301457.2	-	3	243	c.206T>C	c.(205-207)aTc>aCc	p.I69T	NDUFA7_ENST00000598884.1_Missense_Mutation_p.I69T	NM_005001.3	NP_004992.2	O95182	NDUA7_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa	69					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			NS(1)|central_nervous_system(1)|lung(2)|ovary(1)	5					NADH(DB00157)	CGACGACATGATGATGGAAGG	0.617000													31	31					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77614127	77614127	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:77614127C>T	ENST00000461745.1	+	12	2605	c.1705C>T	c.(1705-1707)Cag>Tag	p.Q569*	ROBO2_ENST00000332191.8_Nonsense_Mutation_p.Q569*|ROBO2_ENST00000487694.3_Nonsense_Mutation_p.Q585*	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	569	Fibronectin type-III 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding	p.Q569K(1)		NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAACAGCTGGCAGACCGTGGC	0.448000													4	14					0	0	1	0	0
TMEM184C	55751	broad.mit.edu	37	4	148555573	148555573	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:148555573C>T	ENST00000296582.3	+	10	1879	c.1305C>T	c.(1303-1305)tcC>tcT	p.S435S	TMEM184C_ENST00000508208.1_Intron	NM_018241.2	NP_060711.2	Q9NVA4	T184C_HUMAN	transmembrane protein 184C	435						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(2)|prostate(1)	16						CAGATAAATCCGTGGATTCCT	0.403000													15	19					0	0	1	0	0
CCDC19	25790	broad.mit.edu	37	1	159856423	159856423	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:159856423C>T	ENST00000426543.2	-	6	845	c.390G>A	c.(388-390)caG>caA	p.Q130Q	CCDC19_ENST00000476696.1_5'UTR|CCDC19_ENST00000368099.4_Silent_p.Q215Q			Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	215						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TTTGGATCTGCTGCTTCTCCA	0.498000													55	89					0	0	1	0	0
UMPS	7372	broad.mit.edu	37	3	124456423	124456423	+	Missense_Mutation	SNP	C	C	T	rs145382799		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:124456423C>T	ENST00000232607.2	+	3	425	c.319C>T	c.(319-321)Cgt>Tgt	p.R107C	UMPS_ENST00000413078.2_5'UTR|UMPS_ENST00000538242.1_5'UTR|UMPS_ENST00000536109.1_Missense_Mutation_p.R15C|UMPS_ENST00000498715.1_3'UTR	NM_000373.3	NP_000364.1	P11172	UMPS_HUMAN	uridine monophosphate synthetase	107	OPRTase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(114;0.146)		AGGAACTAAGCGTCTTGTAGA	0.343000													35	57					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8670528	8670528	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8670528G>A	ENST00000270328.4	-	2	334	c.68C>T	c.(67-69)aCg>aTg	p.T23M	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.T23M|ADAMTS10_ENST00000596709.1_Intron			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	23					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GAAGGCGTGCGTGACCTCGAA	0.632000													4	19					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103491098	103491098	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:103491098C>T	ENST00000358392.2	-	7	1322	c.1005G>A	c.(1003-1005)agG>agA	p.R335R	COL11A1_ENST00000353414.4_Silent_p.R284R|COL11A1_ENST00000370096.3_Silent_p.R323R|COL11A1_ENST00000512756.1_Intron	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	323	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CAGAAACATGCCTAGGAGCTT	0.333000													18	47					0	0	1	0	0
NBN	4683	broad.mit.edu	37	8	90993094	90993094	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:90993094G>A	ENST00000265433.3	-	4	502	c.348C>T	c.(346-348)tgC>tgT	p.C116C	NBN_ENST00000409330.1_Silent_p.C34C	NM_002485.4	NP_002476.2	O60934	NBN_HUMAN	nibrin	116	BRCT.				cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AACAAGAAGAGCATGCAACCA	0.343000								Homologous recombination					24	28					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75036839	75036839	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:75036839C>T	ENST00000326665.5	-	14	4773	c.4555G>A	c.(4555-4557)Gag>Aag	p.E1519K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1519										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCTGCAGTCTCGCTTTCTCCT	0.493000													6	114					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197762892	197762892	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:197762892C>T	ENST00000330198.4	+	15	1867	c.1845C>T	c.(1843-1845)aaC>aaT	p.N615N	LMLN_ENST00000482695.1_Silent_p.N600N|LMLN_ENST00000332636.5_Silent_p.N563N|LMLN_ENST00000420910.2_Silent_p.N652N	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	615					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CAGCCACTAACCTGACCCGAG	0.488000													20	40					0	0	1	0	0
FAM214A	56204	broad.mit.edu	37	15	52903327	52903327	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:52903327C>A	ENST00000261844.7	-	5	682	c.530_splice	c.e5+1	p.R177_splice	FAM214A_ENST00000546305.2_Splice_Site_p.R184_splice	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	177																	CTAGACATACCTGTAGAGAAT	0.408000													6	81					0.0293803	0.0295506	1	1	0
POLE2	5427	broad.mit.edu	37	14	50131364	50131364	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:50131364G>A	ENST00000539565.2	-	8	802	c.584C>T	c.(583-585)gCa>gTa	p.A195V	POLE2_ENST00000554396.1_Missense_Mutation_p.A221V|POLE2_ENST00000216367.5_Missense_Mutation_p.A221V|POLE2_ENST00000556584.1_5'UTR	NM_001197330.1	NP_001184259.1	P56282	DPOE2_HUMAN	polymerase (DNA directed), epsilon 2, accessory subunit	221					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	10	all_epithelial(31;0.0021)|Breast(41;0.0124)					GACAAAGCATGCCTCTGTGTA	0.358000													6	86					0	0	1	0	0
CLASP1	23332	broad.mit.edu	37	2	122215273	122215273	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:122215273C>T	ENST00000263710.4	-	14	1764	c.1375G>A	c.(1375-1377)Gca>Aca	p.A459T	CLASP1_ENST00000455322.2_Missense_Mutation_p.A459T|CLASP1_ENST00000409078.3_Missense_Mutation_p.A459T|CLASP1_ENST00000541377.1_Missense_Mutation_p.A459T|CLASP1_ENST00000541859.1_Missense_Mutation_p.A228T|CLASP1_ENST00000397587.3_Missense_Mutation_p.A459T|CLASP1_ENST00000545861.1_Missense_Mutation_p.A227T	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	459					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					CTTCTAACTGCGACAGACTTA	0.338000													13	22					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114177015	114177015	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:114177015C>T	ENST00000357077.4	+	11	1168	c.1115C>T	c.(1114-1116)gCt>gTt	p.A372V	ANK2_ENST00000264366.6_Missense_Mutation_p.A372V|ANK2_ENST00000394537.3_Missense_Mutation_p.A372V|ANK2_ENST00000506722.1_Missense_Mutation_p.A351V	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	372					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTCCACGTTGCTGCGCACTGT	0.542000													38	57					0	0	1	0	0
LYPD4	147719	broad.mit.edu	37	19	42342249	42342249	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42342249C>T	ENST00000330743.3	-	4	1509	c.298G>A	c.(298-300)Gga>Aga	p.G100R	LYPD4_ENST00000343055.4_Missense_Mutation_p.G65R|LYPD4_ENST00000601246.1_Missense_Mutation_p.G65R	NM_173506.4	NP_775777.3	Q6UWN0	LYPD4_HUMAN	LY6/PLAUR domain containing 4	100						anchored to membrane|plasma membrane				breast(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(2)	12						ATGGACACTCCGGGTGGGGAA	0.542000													10	23					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85988974	85988974	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:85988974C>T	ENST00000263360.6	+	11	1826	c.1140C>T	c.(1138-1140)ggC>ggT	p.G380G	EED_ENST00000327320.4_Silent_p.G380G|EED_ENST00000527888.1_Silent_p.G45G|EED_ENST00000351625.6_Silent_p.G405G|EED_ENST00000528180.1_Silent_p.G300G	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	380	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				TTGCATTGGGCAATCAAGTTG	0.313000													32	61					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34072633	34072633	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:34072633C>T	ENST00000254466.6	-	6	1910	c.1883G>A	c.(1882-1884)gGg>gAg	p.G628E	GAS2L2_ENST00000587565.1_Missense_Mutation_p.G612E	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	628					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGGATGACCCCAGACCTTGT	0.577000													33	52					0	0	1	0	0
EML4	27436	broad.mit.edu	37	2	42472683	42472683	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:42472683G>T	ENST00000318522.5	+	2	326	c.64G>T	c.(64-66)Gat>Tat	p.D22Y	EML4_ENST00000402711.2_Missense_Mutation_p.D22Y|EML4_ENST00000482660.1_3'UTR|EML4_ENST00000401738.3_Missense_Mutation_p.D22Y	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	22					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						TGATGTTCAAGATCGCCTGTC	0.368000			T	ALK	NSCLC								5	47					0.000602214	0.000612743	1	1	0
KNSTRN	90417	broad.mit.edu	37	15	40685710	40685710	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40685710G>A	ENST00000249776.8	+	9	978	c.863G>A	c.(862-864)cGa>cAa	p.R288Q	KNSTRN_ENST00000448395.2_3'UTR|KNSTRN_ENST00000416151.2_3'UTR	NM_033286.3	NP_150628.3			kinetochore-localized astrin/SPAG5 binding protein																		GAAAGAGTCCGATTCCTAGAA	0.373000													30	28					0	0	1	0	0
UBA6	55236	broad.mit.edu	37	4	68543398	68543398	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:68543398G>A	ENST00000322244.4	-	6	455	c.396C>T	c.(394-396)taC>taT	p.Y132Y	UBA6_ENST00000420827.2_Silent_p.Y132Y	NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6	132					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding	p.Y132*(1)		central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						TGACATGAACGTATGGATTTA	0.294000													20	31					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72993051	72993051	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:72993051C>A	ENST00000268489.5	-	2	1666	c.994G>T	c.(994-996)Gac>Tac	p.D332Y	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	332					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GGTTCCTTGTCTTTGCCGATC	0.463000													19	69					0.000175454	0.00017952	1	1	0
HIGD2B	123346	broad.mit.edu	37	15	72968598	72968598	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:72968598G>T	ENST00000311755.3	-	3	641	c.118C>A	c.(118-120)Ctt>Att	p.L40I						HIG1 hypoxia inducible domain family, member 2B																		GTCTTGCGAAGGAACTTTTCC	0.577000													7	9					0.000274275	0.000279654	1	1	0
CALML3	810	broad.mit.edu	37	10	5567358	5567358	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:5567358G>A	ENST00000315238.1	+	1	435	c.310G>A	c.(310-312)Gcc>Acc	p.A104T	RP11-116G8.5_ENST00000442008.2_RNA|CALML3-AS1_ENST00000542093.1_RNA|CALML3-AS1_ENST00000545372.1_RNA	NM_005185.2	NP_005176.1	P27482	CALL3_HUMAN	calmodulin-like 3	104	EF-hand 3.						calcium ion binding			endometrium(3)|lung(2)	5						CGTCAGCGCCGCCGAGCTGCG	0.652000													5	12					0	0	1	0	0
ENO2	2026	broad.mit.edu	37	12	7028840	7028840	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:7028840G>A	ENST00000535366.1	+	7	1404	c.778G>A	c.(778-780)Gac>Aac	p.D260N	ENO2_ENST00000545045.2_Missense_Mutation_p.D141N|ENO2_ENST00000544774.1_Missense_Mutation_p.D217N|ENO2_ENST00000541477.1_Missense_Mutation_p.D260N|ENO2_ENST00000538763.1_Missense_Mutation_p.D217N|ENO2_ENST00000229277.1_Missense_Mutation_p.D260N			P09104	ENOG_HUMAN	enolase 2 (gamma, neuronal)	260					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex|plasma membrane	magnesium ion binding|phosphopyruvate hydratase activity			endometrium(3)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						ATATGACTTGGACTTCAAGTC	0.512000													21	25					0	0	1	0	0
RAPH1	65059	broad.mit.edu	37	2	204305754	204305754	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:204305754G>A	ENST00000319170.5	-	14	2458	c.2159C>T	c.(2158-2160)aCc>aTc	p.T720I	RAPH1_ENST00000374493.3_Missense_Mutation_p.T772I|RAPH1_ENST00000457812.1_Intron	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	720					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AGAGCCtggggttgggggtgg	0.612000													7	12					0	0	1	0	0
RP11-1055B8.7	0	broad.mit.edu	37	17	79405428	79405428	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79405428G>A	ENST00000307745.7	+	8	391	c.391G>A	c.(391-393)Gca>Aca	p.A131T																								GGGGAGTCTGGCATCCACCTT	0.582000													10	10					0	0	1	0	0
PUS7	54517	broad.mit.edu	37	7	105146679	105146679	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:105146679C>T	ENST00000356362.2	-	3	654	c.440G>A	c.(439-441)cGg>cAg	p.R147Q	PUS7_ENST00000469408.1_Missense_Mutation_p.R147Q	NM_019042.3	NP_061915.2	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)	147					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						ATGGCTGATCCGTCCATCTTT	0.353000													20	33					0	0	1	0	0
DDR1	780	broad.mit.edu	37	6	30856711	30856711	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30856711C>T	ENST00000324771.8	+	5	660	c.112C>T	c.(112-114)Cag>Tag	p.Q38*	DDR1_ENST00000376568.3_Nonsense_Mutation_p.Q38*|DDR1_ENST00000376569.3_Nonsense_Mutation_p.Q38*|DDR1_ENST00000376575.3_Nonsense_Mutation_p.Q38*|DDR1_ENST00000446312.1_Nonsense_Mutation_p.Q38*|DDR1_ENST00000376570.4_Nonsense_Mutation_p.Q38*|DDR1_ENST00000452441.1_Nonsense_Mutation_p.Q38*|DDR1_ENST00000508312.1_Nonsense_Mutation_p.Q56*|DDR1_ENST00000376567.2_Nonsense_Mutation_p.Q38*|DDR1_ENST00000418800.2_Nonsense_Mutation_p.Q38*|DDR1_ENST00000513240.1_Nonsense_Mutation_p.Q38*|DDR1_ENST00000454612.2_Nonsense_Mutation_p.Q38*			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	38	F5/8 type C.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	CCTGGGCATGCAGGACCGGAC	0.602000													19	19					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753098	76753098	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:76753098C>T	ENST00000536229.3	+	1	1417	c.708C>T	c.(706-708)agC>agT	p.S236S	SALL3_ENST00000575389.2_Silent_p.S369S|SALL3_ENST00000537592.2_Silent_p.S369S			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CTTCCGCCAGCGGCGTCATCT	0.716000													3	5					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231883	7231883	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:7231883C>T	ENST00000383467.2	+	1	761	c.747C>T	c.(745-747)agC>agT	p.S249S		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	249										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						CCCTCCCGAGCGAACTCCACC	0.572000													28	27					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													7	72					0	0	1	0	0
SPDL1	54908	broad.mit.edu	37	5	169031117	169031117	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:169031117C>T	ENST00000265295.4	+	12	2003	c.1724C>T	c.(1723-1725)tCa>tTa	p.S575L		NM_017785.4	NP_060255.3			spindle apparatus coiled-coil protein 1																		AAAGAAACTTCAAGCAAATTG	0.363000													24	33					0	0	1	0	0
ATP6V0A1	535	broad.mit.edu	37	17	40629708	40629708	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40629708T>C	ENST00000343619.4	+	6	577	c.454T>C	c.(454-456)Tca>Cca	p.S152P	ATP6V0A1_ENST00000544137.1_Intron|ATP6V0A1_ENST00000546249.1_Missense_Mutation_p.S152P|ATP6V0A1_ENST00000393829.2_Missense_Mutation_p.S152P|ATP6V0A1_ENST00000537728.1_Missense_Mutation_p.S109P|ATP6V0A1_ENST00000264649.6_Missense_Mutation_p.S159P|ATP6V0A1_ENST00000585525.1_Missense_Mutation_p.S109P	NM_001130021.1	NP_001123493.1	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	152					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		GGAAGAGTCCTCATCCCTCTT	0.443000													18	41					0	0	1	0	0
SLC6A7	6534	broad.mit.edu	37	5	149576691	149576691	+	Missense_Mutation	SNP	G	G	A	rs142334935		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149576691G>A	ENST00000230671.2	+	4	807	c.436G>A	c.(436-438)Gcc>Acc	p.A146T	SLC6A7_ENST00000524041.1_Missense_Mutation_p.A146T	NM_014228.3	NP_055043.2	Q99884	SC6A7_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 7	146						integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)|stomach(1)	16		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	CTACCTCTTCGCCTCCCTCAC	0.612000													18	26					0	0	1	0	0
ZNF598	90850	broad.mit.edu	37	16	2051609	2051609	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2051609G>A	ENST00000563630.1	-	6	1065	c.823C>T	c.(823-825)Cgc>Tgc	p.R275C	ZNF598_ENST00000431526.1_Missense_Mutation_p.R330C|ZNF598_ENST00000562103.1_Missense_Mutation_p.R275C			Q86UK7	ZN598_HUMAN	zinc finger protein 598	330						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						CTTCCTCGGCGGCTCTGCTGG	0.682000													3	14					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20871916	20871916	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:20871916G>A	ENST00000262715.5	-	6	1200	c.1160C>T	c.(1159-1161)gCc>gTc	p.A387V	TEP1_ENST00000556935.1_Intron	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	387	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GTGTCTCTTGGCCCGGTGCTT	0.637000													27	42					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43161904	43161904	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:43161904C>T	ENST00000352483.2	-	9	1657	c.1593G>A	c.(1591-1593)gtG>gtA	p.V531V	RIPK4_ENST00000332512.3_Silent_p.V483V|RIPK4_ENST00000542057.1_Silent_p.V420V|RIPK4_ENST00000544709.1_Silent_p.V420V			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	483						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CGACACCCCGCACCCTCCTCT	0.632000													33	15					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119964755	119964755	+	Missense_Mutation	SNP	C	C	A	rs143038843		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:119964755C>A	ENST00000543831.1	+	4	880	c.631C>A	c.(631-633)Ctg>Atg	p.L211M	HSD3B2_ENST00000369416.3_Missense_Mutation_p.L211M	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	211					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CAATGGGATCCTGTCAAGTGT	0.507000													20	58					1.96292e-10	2.09789e-10	1	1	0
GREB1	9687	broad.mit.edu	37	2	11721028	11721028	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:11721028G>A	ENST00000389825.3	+	6	952	c.641G>A	c.(640-642)gGa>gAa	p.G214E	GREB1_ENST00000234142.5_Intron|GREB1_ENST00000263834.5_Intron|GREB1_ENST00000381483.2_Intron|GREB1_ENST00000381486.2_Intron			Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	0						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GGGGGCATGGGAGCTGCTGGG	0.657000													6	10					0	0	1	0	0
ZNF839	55778	broad.mit.edu	37	14	102798054	102798054	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:102798054C>T	ENST00000262236.5	+	3	1294	c.939C>T	c.(937-939)cgC>cgT	p.R313R	ZNF839_ENST00000442396.2_Silent_p.R429R|ZNF839_ENST00000559185.1_Silent_p.R313R|ZNF839_ENST00000558850.1_Silent_p.R313R	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	313						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CTAGAAGACGCGCATGCTCAG	0.552000													4	8					0	0	1	0	0
PTGS2	5743	broad.mit.edu	37	1	186648454	186648454	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:186648454G>A	ENST00000367468.5	-	2	305	c.169_splice	c.e2+1	p.P57_splice	PTGS2_ENST00000490885.2_5'UTR	NM_000963.2	NP_000954.1	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	57					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	ACAAACTTACGTGTTGAGCAG	0.433000													19	23					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104314442	104314442	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:104314442G>A	ENST00000389120.3	+	12	1518	c.1428G>A	c.(1426-1428)atG>atA	p.M476I		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	476					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		ACAGGGAGATGCGCCACCTCA	0.478000													38	35					0	0	1	0	0
TRPV3	162514	broad.mit.edu	37	17	3435992	3435992	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3435992G>T	ENST00000301365.4	-	8	1155	c.1024C>A	c.(1024-1026)Ctc>Atc	p.L342I	TRPV3_ENST00000572519.1_Missense_Mutation_p.L342I|TRPV3_ENST00000576742.1_Missense_Mutation_p.L342I			Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel, subfamily V, member 3	342						integral to membrane	calcium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(12)|ovary(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	35					Menthol(DB00825)	AGCGGCGTGAGGCCATCGTTG	0.627000													10	18					1.58986e-06	1.65464e-06	1	1	0
NBPF1	55672	broad.mit.edu	37	1	16893834	16893834	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16893834C>A	ENST00000430580.2	-	25	3566	c.2679G>T	c.(2677-2679)gaG>gaT	p.E893D	NBPF1_ENST00000420031.2_3'UTR|NBPF1_ENST00000432949.1_Missense_Mutation_p.A297S	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	893	NBPF 5.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CATCCAGCAGCTCCCTGCTGA	0.483000													48	2204					0.146539	0.147128	1	1	0
L1TD1	54596	broad.mit.edu	37	1	62672630	62672630	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:62672630A>G	ENST00000498273.1	+	3	625	c.330A>G	c.(328-330)ttA>ttG	p.L110L		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	110										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						atttagcattacaaaaaacag	0.333000													20	46					0	0	1	0	0
RNF14	9604	broad.mit.edu	37	5	141364434	141364434	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:141364434G>A	ENST00000394520.2	+	8	1612	c.1303G>A	c.(1303-1305)Ggt>Agt	p.G435S	RNF14_ENST00000394514.2_Missense_Mutation_p.G309S|RNF14_ENST00000394519.1_Missense_Mutation_p.G435S|RNF14_ENST00000347642.3_Missense_Mutation_p.G435S|RNF14_ENST00000540015.1_Missense_Mutation_p.G132S|RNF14_ENST00000356143.1_Missense_Mutation_p.G435S|RNF14_ENST00000394515.3_Missense_Mutation_p.G259S	NM_001201365.1|NM_004290.4	NP_001188294.1|NP_004281.1	Q9UBS8	RNF14_HUMAN	ring finger protein 14	435	Interaction with androgen receptor.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GATTTGCATGGGTTCTCTCTC	0.403000													34	69					0	0	1	0	0
ZIC3	7547	broad.mit.edu	37	X	136649562	136649562	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:136649562G>A	ENST00000287538.5	+	1	1262	c.712G>A	c.(712-714)Gcc>Acc	p.A238T	ZIC3_ENST00000370606.3_Missense_Mutation_p.A238T	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	238					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					CGGGCCCGGCGCCTTCTTCCG	0.642000													14	2					0	0	1	0	0
CRYGN	155051	broad.mit.edu	37	7	151135186	151135186	+	Missense_Mutation	SNP	C	C	T	rs147779621		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:151135186C>T	ENST00000337323.2	-	2	292	c.166G>A	c.(166-168)Gac>Aac	p.D56N	RP4-555L14.4_ENST00000465549.1_RNA|CRYGN_ENST00000476631.1_5'UTR	NM_144727.1	NP_653328.1	Q8WXF5	CRGN_HUMAN	crystallin, gamma N	56	Beta/gamma crystallin 'Greek key' 2.									central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(1)|lung(4)	8			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCCGGAAGTCGGGGTGATTG	0.607000													27	18					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	602481	602481	+	Silent	SNP	C	C	T	rs146988309		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:602481C>T	ENST00000219611.2	+	11	3051	c.2688C>T	c.(2686-2688)tgC>tgT	p.C896C	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		TGGTGTGCTGCGCCTTCAACC	0.711000													8	19					0	0	1	0	0
PCDH1	5097	broad.mit.edu	37	5	141248331	141248331	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:141248331C>T	ENST00000287008.3	-	2	853	c.706G>A	c.(706-708)Ggc>Agc	p.G236S	PCDH1_ENST00000536585.1_Missense_Mutation_p.G214S|PCDH1_ENST00000394536.3_Missense_Mutation_p.G236S|PCDH1_ENST00000503492.1_Missense_Mutation_p.G236S|PCDH1_ENST00000456271.1_Missense_Mutation_p.G224S	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	236	Cadherin 2.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TCCAGGTTGCCCATCACAATG	0.637000													19	15					0	0	1	0	0
LYN	4067	broad.mit.edu	37	8	56863270	56863270	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:56863270C>T	ENST00000520220.2	+	6	625	c.351C>T	c.(349-351)gaC>gaT	p.D117D	LYN_ENST00000519728.1_Silent_p.D138D	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	138	SH3.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			CCAGGAAGGACGCAGAAAGGC	0.383000													27	36					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45515383	45515383	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45515383C>T	ENST00000221452.8	+	4	503	c.353C>T	c.(352-354)gCg>gTg	p.A118V	RELB_ENST00000540120.1_Missense_Mutation_p.A118V|RELB_ENST00000505236.1_Missense_Mutation_p.A115V	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	118						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		GTGTCCCCAGCGCCGGGCCCG	0.776000													4	15					0	0	1	0	0
IL16	3603	broad.mit.edu	37	15	81592597	81592597	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:81592597C>T	ENST00000394660.2	+	14	3290	c.2930C>T	c.(2929-2931)aCg>aTg	p.T977M	IL16_ENST00000302987.4_Missense_Mutation_p.T977M|IL16_ENST00000394652.2_Missense_Mutation_p.T276M	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	977					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						TCCTGTGAGACGAAGCTACTT	0.532000													10	17					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36704095	36704095	+	Missense_Mutation	SNP	A	A	G	rs150977654	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:36704095A>G	ENST00000280527.2	+	6	1422	c.1055A>G	c.(1054-1056)gAc>gGc	p.D352G		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	352	VWFC 1.				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				TTTCGAATGGACAACTGTCGG	0.463000													39	42					0	0	1	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18637333	18637333	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18637333G>A	ENST00000336349.5	-	3	723	c.488C>T	c.(487-489)gCc>gTc	p.A163V	SPTY2D1_ENST00000543776.1_5'UTR	NM_194285.2	NP_919261.2	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	163										breast(4)|cervix(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|skin(1)|stomach(1)	30						GGGTGGTGGGGCACTTTTAAG	0.468000													4	74					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900983	51900983	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:51900983C>T	ENST00000268919.4	+	1	745	c.589C>T	c.(589-591)Cac>Tac	p.H197Y		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	197					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GTATCGCAGGCACCTGGACAG	0.572000													10	19					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65417640	65417640	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65417640G>T	ENST00000394224.3	+	14	3176	c.2880G>T	c.(2878-2880)aaG>aaT	p.K960N	SIPA1_ENST00000534313.1_Missense_Mutation_p.K960N|SIPA1_ENST00000394227.3_Missense_Mutation_p.K858N|SIPA1_ENST00000527525.1_Missense_Mutation_p.K858N	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	960					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						GAGACCCTAAGGGAACTCCAA	0.607000													4	66					2.56e-06	2.66106e-06	1	1	0
AHNAK	79026	broad.mit.edu	37	11	62284495	62284495	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62284495C>T	ENST00000378024.4	-	5	17668	c.17394G>A	c.(17392-17394)acG>acA	p.T5798T	AHNAK_ENST00000525875.1_5'UTR|AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5798					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CAAACTCCAGCGTCCCCGTCG	0.483000													31	47					0	0	1	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555268	44555268	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:44555268C>A	ENST00000330682.2	-	1	1181	c.946G>T	c.(946-948)Gtg>Ttg	p.V316L	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	316	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						TTAGCGTTCACTCTGCGTCCA	0.642000													16	761					7.41877e-09	7.84611e-09	1	1	0
PSG9	5678	broad.mit.edu	37	19	43766195	43766195	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:43766195C>T	ENST00000244293.7	-	3	592	c.526G>A	c.(526-528)Gca>Aca	p.A176T	PSG9_ENST00000291752.5_Intron|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000270077.3_Missense_Mutation_p.A176T|PSG9_ENST00000443718.3_Intron|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000593948.1_Missense_Mutation_p.A176T			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	176	Ig-like C2-type 1.		A -> T (in dbSNP:rs1058085).		female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				AGGTAGCTTGCGTCCAGAGTC	0.527000													8	201					0	0	1	0	0
BCAT2	587	broad.mit.edu	37	19	49309972	49309972	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49309972A>G	ENST00000316273.6	-	3	114	c.102T>C	c.(100-102)gcT>gcC	p.A34A	BCAT2_ENST00000598162.1_Silent_p.A34A|BCAT2_ENST00000597011.1_5'UTR|BCAT2_ENST00000545387.2_Intron|BCAT2_ENST00000402551.1_5'UTR|BCAT2_ENST00000599246.1_Intron	NM_001190.3	NP_001181.2	O15382	BCAT2_HUMAN	branched chain amino-acid transaminase 2, mitochondrial	34						mitochondrial matrix	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity	p.A35fs*7(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	12		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.000366)|Epithelial(262;0.0195)|GBM - Glioblastoma multiforme(486;0.0224)	L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|Pyridoxal Phosphate(DB00114)	GCAGGTCTGCAGCCTGAGGAA	0.547000													22	22					0	0	1	0	0
NOM1	64434	broad.mit.edu	37	7	156754894	156754894	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:156754894G>A	ENST00000275820.3	+	5	1697	c.1682G>A	c.(1681-1683)cGc>cAc	p.R561H		NM_138400.1	NP_612409.1	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	561					RNA metabolic process	nucleolus	protein binding	p.R561H(1)		endometrium(5)|kidney(4)|large_intestine(9)|lung(7)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		AATGACATGCGCAAAATTCCA	0.433000													50	91					0	0	1	0	0
SPPL2A	84888	broad.mit.edu	37	15	51039785	51039785	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:51039785G>A	ENST00000261854.5	-	5	765	c.491C>T	c.(490-492)tCg>tTg	p.S164L	RP11-507J18.2_ENST00000558317.1_RNA	NM_032802.3	NP_116191.2	Q8TCT8	PSL2_HUMAN	signal peptide peptidase like 2A	164						integral to membrane	aspartic-type endopeptidase activity	p.S164L(2)		endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		GTTAGGCCACGATGGAGAATA	0.353000													49	63					0	0	1	0	0
RAF1	5894	broad.mit.edu	37	3	12653484	12653484	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:12653484G>A	ENST00000251849.4	-	3	724	c.285C>T	c.(283-285)tgC>tgT	p.C95C	RAF1_ENST00000542177.1_Intron|RAF1_ENST00000442415.2_Silent_p.C95C	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	95	RBD.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	ACACTGCACAGCACTCTGGTT	0.443000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				6	121					0	0	1	0	0
NELFE	7936	broad.mit.edu	37	6	31926208	31926208	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31926208G>A	ENST00000375429.3	-	2	242	c.16C>T	c.(16-18)Ccc>Tcc	p.P6S	NELFE_ENST00000444811.2_Missense_Mutation_p.P6S|NELFE_ENST00000375425.5_Missense_Mutation_p.P13S	NM_002904.5	NP_002895.3			negative elongation factor complex member E																		CTCAGTCCGGGGGGTATCACC	0.552000													18	59					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29775373	29775373	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:29775373G>T	ENST00000375398.2	-	27	5048	c.4599C>A	c.(4597-4599)ttC>ttA	p.F1533L	SVIL_ENST00000538146.1_Missense_Mutation_p.F325L|SVIL_ENST00000375400.3_Missense_Mutation_p.F1107L|SVIL_ENST00000355867.4_Missense_Mutation_p.F1533L|PTCHD3P1_ENST00000413405.1_RNA|SVIL_ENST00000535393.1_Missense_Mutation_p.F447L			O95425	SVIL_HUMAN	supervillin	1533	Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				GAAGCTTCCAGAAGTCTTTGG	0.403000													54	67					3.10202e-16	3.40411e-16	1	1	0
ZNF407	55628	broad.mit.edu	37	18	72775125	72775125	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:72775125C>T	ENST00000299687.5	+	8	5448	c.5448C>T	c.(5446-5448)taC>taT	p.Y1816Y		NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1816					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CCAAGTCGTACGAGTGCCGTC	0.557000													24	45					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68234491	68234491	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:68234491T>G	ENST00000347230.4	-	31	5858	c.5720A>C	c.(5719-5721)gAg>gCg	p.E1907A	ZFYVE26_ENST00000555452.1_Missense_Mutation_p.E1907A	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1907					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CCATTCCACCTCATCTGCTTT	0.433000													22	29					0	0	1	0	0
PSMB5	5693	broad.mit.edu	37	14	23503907	23503907	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23503907T>C	ENST00000361611.6	-	1	447	c.184A>G	c.(184-186)Acc>Gcc	p.T62A	PSMB5_ENST00000493471.2_Missense_Mutation_p.T62A|PSMB5_ENST00000425762.2_Intron|PSMB5_ENST00000460922.2_Missense_Mutation_p.T62A	NM_002797.3	NP_002788.1	P28074	PSB5_HUMAN	proteasome (prosome, macropain) subunit, beta type, 5	62					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus	protein binding|threonine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	7	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0121)	Bortezomib(DB00188)	AAGGCCAGGGTGGTTGTTCCA	0.632000													3	10					0	0	1	0	0
HSPH1	10808	broad.mit.edu	37	13	31724164	31724164	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:31724164G>A	ENST00000320027.5	-	8	1408	c.1064C>T	c.(1063-1065)gCc>gTc	p.A355V	HSPH1_ENST00000380406.5_Missense_Mutation_p.A314V|HSPH1_ENST00000429785.2_Missense_Mutation_p.A174V|HSPH1_ENST00000380405.4_Missense_Mutation_p.A355V|HSPH1_ENST00000445273.2_Missense_Mutation_p.A357V	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	355					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		AAAGAATTTGGCAATTCTTTC	0.413000													41	47					0	0	1	0	0
FOXO3	2309	broad.mit.edu	37	6	108984784	108984784	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:108984784C>T	ENST00000406360.1	+	2	1091	c.748C>T	c.(748-750)Cgg>Tgg	p.R250W	FOXO3_ENST00000540898.1_Missense_Mutation_p.R30W|FOXO3_ENST00000343882.6_Missense_Mutation_p.R250W	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	250					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		CCCCCGGCGGCGGGCTGTCTC	0.592000													6	24					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77526597	77526597	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:77526597G>T	ENST00000461745.1	+	3	1321	c.421G>T	c.(421-423)Gat>Tat	p.D141Y	ROBO2_ENST00000332191.8_Missense_Mutation_p.D141Y|ROBO2_ENST00000487694.3_Missense_Mutation_p.D157Y	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	141	Ig-like C2-type 2.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AAACCCCACAGATGTTGTAGT	0.463000													38	62					7.63091e-17	8.38933e-17	1	1	0
NKAPL	222698	broad.mit.edu	37	6	28227632	28227632	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:28227632G>A	ENST00000343684.3	+	1	535	c.483G>A	c.(481-483)acG>acA	p.T161T		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	161										breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						AAGAGGTAACGCATCAGAAAA	0.453000													12	75					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	621235	621235	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:621235C>T	ENST00000588649.2	-	10	2547	c.2463G>A	c.(2461-2463)gcG>gcA	p.A821A		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	821	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding	p.A821A(1)		cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGGGCCCGCGCCACGTCGC	0.697000													6	12					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90321624	90321624	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:90321624A>G	ENST00000469640.2	+	27	4088	c.3713A>G	c.(3712-3714)gAc>gGc	p.D1238G	DAPK1_ENST00000358077.5_Missense_Mutation_p.D1213G|DAPK1_ENST00000472284.1_Missense_Mutation_p.D1213G|DAPK1_ENST00000491893.1_Missense_Mutation_p.D1147G|DAPK1_ENST00000408954.3_Missense_Mutation_p.D1213G			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1213					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						CTGCTGCTGGACTCGGTGTGC	0.647000									Chronic Lymphocytic Leukemia, Familial Clustering of				7	9					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65413816	65413816	+	Missense_Mutation	SNP	C	C	T	rs146280906		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65413816C>T	ENST00000394224.3	+	7	1684	c.1388C>T	c.(1387-1389)gCa>gTa	p.A463V	SIPA1_ENST00000534313.1_Missense_Mutation_p.A463V|SIPA1_ENST00000394227.3_Missense_Mutation_p.A463V|SIPA1_ENST00000527525.1_Missense_Mutation_p.A463V	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	463	Rap-GAP.				cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						GTGGTGCGGGCACACACACCC	0.642000													12	12					0	0	1	0	0
ABHD17C	58489	broad.mit.edu	37	15	81046578	81046578	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:81046578C>T	ENST00000258884.4	+	3	984	c.857C>T	c.(856-858)gCg>gTg	p.A286V	ABHD17C_ENST00000559506.1_3'UTR|ABHD17C_ENST00000560609.1_Missense_Mutation_p.A51V|ABHD17C_ENST00000558464.1_Missense_Mutation_p.A252V	NM_021214.1	NP_067037.1			abhydrolase domain containing 17C																		CATGGCCTAGCGATGTACGAG	0.478000													21	17					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814722	106814722	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:106814722G>A	ENST00000407775.2	+	8	2662	c.2412G>A	c.(2410-2412)acG>acA	p.T804T	ZFPM2_ENST00000378472.4_Silent_p.T535T|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Silent_p.T672T|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000520492.1_Silent_p.T672T|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	804					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding	p.T804T(1)		NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CTTCTCTGACGATCAACAAGT	0.443000													6	15					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43817299	43817299	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43817299C>T	ENST00000382031.1	+	5	4373	c.4342C>T	c.(4342-4344)Ctg>Ttg	p.L1448L	MAP1A_ENST00000399453.1_Silent_p.L1210L|MAP1A_ENST00000300231.5_Silent_p.L1210L			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1210						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGAGACCTCCCTGGATGTCTC	0.522000													29	40					0	0	1	0	0
GRM3	0	broad.mit.edu	37	7	86415812	86415812	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:86415812G>A	ENST00000361669.2	+	3	1803	c.704G>A	c.(703-705)cGc>cAc	p.R235H	GRM3_ENST00000394720.2_Missense_Mutation_p.R233H|AC005009.2_ENST00000452471.1_RNA|GRM3_ENST00000546348.1_Intron|AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000536043.1_Missense_Mutation_p.R107H|GRM3_ENST00000439827.1_Missense_Mutation_p.R235H	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	235					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CAGGAAGCCCGCCTGCGCAAC	0.597000													9	14					0	0	1	0	0
ZBTB5	9925	broad.mit.edu	37	9	37441732	37441732	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:37441732G>A	ENST00000307750.4	-	2	1005	c.817C>T	c.(817-819)Ccc>Tcc	p.P273S		NM_014872.2	NP_055687.1	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	8				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)		GACTGGCTGGGCACCTGGGCA	0.473000													33	44					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15669887	15669887	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:15669887C>T	ENST00000281171.4	+	9	2106	c.1776C>T	c.(1774-1776)tcC>tcT	p.S592S	PTPRO_ENST00000348962.2_Silent_p.S592S|PTPRO_ENST00000543886.1_Silent_p.S592S	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	592	Fibronectin type-III 6.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TAACTGCATCCGTGGTAATCT	0.368000													4	85					0	0	1	0	0
SSTR4	6754	broad.mit.edu	37	20	23016836	23016836	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:23016836G>A	ENST00000255008.3	+	1	780	c.716G>A	c.(715-717)cGc>cAc	p.R239H	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	239					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GGCAAGATGCGCGCCGTGGCC	0.642000													22	47					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368664	86368664	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:86368664C>A	ENST00000400286.2	-	2	2578	c.1980G>T	c.(1978-1980)atG>atT	p.M660I		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	660						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TATGGCCATACATGCTGTACT	0.443000													3	55					1	1	1	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5237184	5237184	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:5237184G>A	ENST00000274181.7	+	14	2264	c.2126G>A	c.(2125-2127)cGt>cAt	p.R709H	ADAMTS16_ENST00000513709.1_Intron	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	709	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						GAGGATAGCCGTAATGTTTGT	0.403000													24	49					0	0	1	0	0
USP14	9097	broad.mit.edu	37	18	192883	192883	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:192883C>T	ENST00000261601.6	+	6	537	c.446C>T	c.(445-447)gCg>gTg	p.A149V	USP14_ENST00000582707.1_Missense_Mutation_p.A114V|USP14_ENST00000383589.2_Missense_Mutation_p.A103V|USP14_ENST00000400266.3_Missense_Mutation_p.A138V	NM_005151.3	NP_005142.1	P54578	UBP14_HUMAN	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	149					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(2)	11		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				ATGGCTTCAGCGCAGTATATT	0.368000													32	58					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74454146	74454146	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74454146G>T	ENST00000394019.2	-	27	3425	c.3028C>A	c.(3028-3030)Ctc>Atc	p.L1010I	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Missense_Mutation_p.P950H|SLC4A5_ENST00000357822.5_Missense_Mutation_p.L1026I|SLC4A5_ENST00000377632.1_Intron|SLC4A5_ENST00000359484.4_Missense_Mutation_p.L908I|SLC4A5_ENST00000358683.4_Missense_Mutation_p.L908I|SLC4A5_ENST00000346834.4_Intron|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377634.4_Missense_Mutation_p.L1026I	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1026						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GCCAGGCAGAGGATCTGCACC	0.642000													22	38					1.10923e-09	1.18008e-09	1	1	0
RPS6KB2	6199	broad.mit.edu	37	11	67201898	67201898	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67201898G>A	ENST00000312629.5	+	13	1143	c.1098G>A	c.(1096-1098)acG>acA	p.T366T	AP003419.16_ENST00000535922.1_RNA	NM_003952.2	NP_003943.2	Q9UBS0	KS6B2_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 2	366	AGC-kinase C-terminal.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of translational initiation|translation	nucleoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|salivary_gland(1)|stomach(2)	25			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CACGGCAGACGCCGGTGGACA	0.647000													9	15					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10789860	10789860	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10789860C>T	ENST00000449870.1	+	7	1056	c.739C>T	c.(739-741)Cga>Tga	p.R247*	ILF3_ENST00000407004.3_Nonsense_Mutation_p.R247*|ILF3_ENST00000589998.1_Nonsense_Mutation_p.R247*|ILF3_ENST00000588657.1_Nonsense_Mutation_p.R247*|ILF3_ENST00000318511.3_Nonsense_Mutation_p.R247*|ILF3_ENST00000590261.1_Nonsense_Mutation_p.R247*|ILF3_ENST00000250241.8_Nonsense_Mutation_p.R247*|ILF3_ENST00000420083.1_Nonsense_Mutation_p.R247*|ILF3_ENST00000592763.1_Nonsense_Mutation_p.R247*	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	247	DZF.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GGGTCCCCTCCGAGGCTGGGT	0.597000													19	20					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67681780	67681780	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67681780C>A	ENST00000334583.6	+	13	1318	c.990C>A	c.(988-990)acC>acA	p.T330T	RLTPR_ENST00000545661.1_Silent_p.T330T	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	330										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CACTGGCCACCAATGCCGCCT	0.677000													14	21					6.31663e-08	6.64488e-08	1	1	0
LAMA5	3911	broad.mit.edu	37	20	60892518	60892518	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:60892518C>T	ENST00000252999.3	-	55	7460	c.7394G>A	c.(7393-7395)cGg>cAg	p.R2465Q		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2465	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGTGGGGTCCGAGCCCCATC	0.672000													8	17					0	0	1	0	0
GLB1	2720	broad.mit.edu	37	3	33099744	33099744	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:33099744G>A	ENST00000307363.5	-	6	714	c.570C>T	c.(568-570)ggC>ggT	p.G190G	GLB1_ENST00000399402.3_Silent_p.G160G|GLB1_ENST00000445488.2_Silent_p.G238G|GLB1_ENST00000307377.8_Intron	NM_000404.2	NP_000395.2	P16278	BGAL_HUMAN	galactosidase, beta 1	190			G -> D (in GM1G1; 3.4% of wild-type enzyme activity).		carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				CAAAGTAGCTGCCATATTCAT	0.458000													12	25					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24397623	24397623	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24397623T>C	ENST00000330966.7	-	25	3299	c.3137A>G	c.(3136-3138)gAg>gGg	p.E1046G	MYOM3_ENST00000329601.7_Missense_Mutation_p.E1045G|MYOM3_ENST00000374434.3_Missense_Mutation_p.E1045G|RP11-293P20.4_ENST00000429191.1_RNA|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	1045										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GCTGAAGATCTCCTTGTTGTT	0.562000											OREG0013235	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	36					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26688416	26688416	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26688416C>T	ENST00000436292.1	-	7	1421	c.1301G>A	c.(1300-1302)cGc>cAc	p.R434H	ZNF683_ENST00000374204.1_Missense_Mutation_p.R414H|ZNF683_ENST00000349618.3_Missense_Mutation_p.R414H|ZNF683_ENST00000403843.1_Missense_Mutation_p.R434H			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		CTGGGTGAAGCGACTCCGGCA	0.667000													22	32					0	0	1	0	0
C19orf40	91442	broad.mit.edu	37	19	33465049	33465049	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:33465049G>A	ENST00000588258.1	+	4	437	c.327G>A	c.(325-327)gtG>gtA	p.V109V	C19orf40_ENST00000589646.1_Silent_p.V14V|C19orf40_ENST00000590281.1_Silent_p.V109V|C19orf40_ENST00000590179.1_Silent_p.V14V	NM_152266.3	NP_689479.1	Q9BTP7	FAP24_HUMAN	chromosome 19 open reading frame 40	109					DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Esophageal squamous(110;0.137)					AGTTTACTGTGCTGGACCTTG	0.468000								Direct reversal of damage					26	36					0	0	1	0	0
BAG2	9532	broad.mit.edu	37	6	57048805	57048805	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:57048805T>C	ENST00000370693.5	+	3	825	c.453T>C	c.(451-453)gtT>gtC	p.V151V	BAG2_ENST00000545080.1_Silent_p.V118V	NM_004282.3	NP_004273.1	O95816	BAG2_HUMAN	BCL2-associated athanogene 2	151	BAG.				apoptosis|protein folding		protein binding			endometrium(1)|large_intestine(1)	2	Lung NSC(77;0.126)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ATGGGCCAGTTGATCAGAAGT	0.393000													32	54					0	0	1	0	0
HID1	283987	broad.mit.edu	37	17	72954478	72954478	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72954478G>A	ENST00000425042.2	-	11	1413	c.1336C>T	c.(1336-1338)Cgc>Tgc	p.R446C		NM_030630.2	NP_085133.1			HID1 domain containing																		ATGGGCACGCGGATTGAGTAG	0.642000											OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	7					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	9017178	9017178	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:9017178G>A	ENST00000344836.4	-	3	475	c.277C>T	c.(277-279)Cga>Tga	p.R93*	USP7_ENST00000381886.4_Nonsense_Mutation_p.R77*|USP7_ENST00000566224.1_5'UTR|USP7_ENST00000535863.1_5'UTR	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	93	Interaction with TSPYL5.|Interaction with p53/TP53, MDM2 and EBNA1.|MATH.|Necessary for nuclear localization.				interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						GGCAGATTTCGCACAAAACAC	0.498000													17	41					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19744908	19744908	+	Missense_Mutation	SNP	G	G	A	rs139822718		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19744908G>A	ENST00000203556.4	-	19	2313	c.2176C>T	c.(2176-2178)Cgg>Tgg	p.R726W	GMIP_ENST00000587238.1_Missense_Mutation_p.R700W|GMIP_ENST00000445806.2_Missense_Mutation_p.R697W	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	726	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CTGGCTGCCCGCGGGCCGTCC	0.612000													18	34					0	0	1	0	0
CAPNS1	826	broad.mit.edu	37	19	36633826	36633826	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36633826G>A	ENST00000246533.3	+	5	947	c.349G>A	c.(349-351)Gcc>Acc	p.A117T	CAPNS1_ENST00000587718.1_Missense_Mutation_p.A117T|CAPNS1_ENST00000590874.1_Missense_Mutation_p.A87T|CAPNS1_ENST00000589146.1_Intron|CAPNS1_ENST00000588815.1_Missense_Mutation_p.A117T|CAPNS1_ENST00000588780.1_Missense_Mutation_p.A117T	NM_001003962.1|NM_001749.2	NP_001003962.1|NP_001740.1	P04632	CPNS1_HUMAN	calpain, small subunit 1	117	EF-hand 1; atypical.				positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGAGGTCAGCGCCACAGAACT	0.522000													18	21					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24669871	24669871	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:24669871C>T	ENST00000376454.3	+	3	458	c.428C>T	c.(427-429)aCg>aTg	p.T143M	KIAA1217_ENST00000458595.1_Missense_Mutation_p.T143M|KIAA1217_ENST00000376462.1_Missense_Mutation_p.T63M|KIAA1217_ENST00000376452.3_Missense_Mutation_p.T143M|KIAA1217_ENST00000430453.2_Missense_Mutation_p.T64M	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	143					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						TTATCAGAGACGTCCGCTGAT	0.547000													20	27					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169129425	169129425	+	Silent	SNP	G	G	A	rs144520292	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:169129425G>A	ENST00000256935.8	+	14	1457	c.1377G>A	c.(1375-1377)acG>acA	p.T459T		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	459	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATGGCAAAACGCTGCCTGTAA	0.502000											OREG0017017	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	29					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91779572	91779572	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:91779572G>A	ENST00000389857.6	-	15	2674	c.2588C>T	c.(2587-2589)tCc>tTc	p.S863F		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	863					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CTCAACGGCGGACAGTTTGGC	0.622000													39	53					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45284308	45284308	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45284308G>A	ENST00000270279.3	+	2	563	c.500_splice	c.e2+1	p.R167_splice	CBLC_ENST00000341505.4_Splice_Site_p.R167_splice	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	167	Cbl-PTB.|EF-hand-like.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				TGCGGAGCCCGGTGAGTAAGC	0.652000			M		AML								5	15					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97877447	97877447	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:97877447G>A	ENST00000420699.2	+	58	3682	c.3438G>A	c.(3436-3438)acG>acA	p.T1146T	ANKRD36_ENST00000461153.2_Silent_p.T1146T	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	1146										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						ATATGGCCACGGAAAAAAAGG	0.333000													4	5					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131482744	131482744	+	Silent	SNP	G	G	A	rs141598296		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131482744G>A	ENST00000291906.4	+	22	2922	c.2529G>A	c.(2527-2529)gcG>gcA	p.A843A		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	843	AGC-kinase C-terminal.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						GTGGCCCTGCGGACCTGCGCT	0.687000													30	44					0	0	1	0	0
TAS2R20	259295	broad.mit.edu	37	12	11149790	11149790	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:11149790G>A	ENST00000538986.1	-	1	684	c.685C>T	c.(685-687)Caa>Taa	p.Q229*	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176889.2	NP_795370.2	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	229					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13						GTCACAGTTTGCAGAGCTTTT	0.388000													42	65					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43908866	43908866	+	Silent	SNP	G	G	A	rs140309222	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43908866G>A	ENST00000562955.1	+	59	8256	c.8256G>A	c.(8254-8256)gaG>gaA	p.E2752E	SZT2_ENST00000372442.1_Silent_p.E1910E	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2809						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CAGAGCTGGAGCGCCAGATGA	0.562000													21	17					0	0	1	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64132774	64132774	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64132774G>A	ENST00000528057.1	+	9	996	c.906_splice	c.e9-1	p.G303_splice	RPS6KA4_ENST00000294261.4_Splice_Site_p.G303_splice|RPS6KA4_ENST00000334205.4_Splice_Site_p.G303_splice	NM_001006944.1	NP_001006945.1	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 4	303	AGC-kinase C-terminal.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			breast(1)|endometrium(3)|lung(7)|ovary(1)|prostate(1)	13						TTCCCTCAGGGCCTCGATTGG	0.592000													18	16					0	0	1	0	0
ZNF614	80110	broad.mit.edu	37	19	52521726	52521726	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:52521726C>T	ENST00000270649.6	-	3	581	c.37G>A	c.(37-39)Gtg>Atg	p.V13M	ZNF614_ENST00000356322.6_Missense_Mutation_p.V13M	NM_025040.3	NP_079316.2	Q8N883	ZN614_HUMAN	zinc finger protein 614	13	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TCCACAGCCACATCCTCCAGG	0.398000													28	34					0	0	1	0	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933435	31933435	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:31933435C>T	ENST00000334849.2	-	1	198	c.174G>A	c.(172-174)tgG>tgA	p.W58*		NM_181614.1	NP_853645.1	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	58						intermediate filament				endometrium(1)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	11						ATCCAGAAGACCAGTATCCCC	0.433000													23	13					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176450	57176450	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:57176450G>A	ENST00000537055.2	-	2	348	c.117C>T	c.(115-117)gcC>gcT	p.A39A		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						TGCAGGCCACGGCCTCTGGCT	0.602000													10	34					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123844901	123844901	+	Silent	SNP	G	G	A	rs149803621	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:123844901G>A	ENST00000369005.1	+	4	3226	c.2886G>A	c.(2884-2886)tcG>tcA	p.S962S	TACC2_ENST00000515603.1_Silent_p.S962S|TACC2_ENST00000334433.3_Silent_p.S962S|TACC2_ENST00000453444.2_Silent_p.S962S|TACC2_ENST00000515273.1_Silent_p.S962S|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	962						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CGAGGGTCTCGCCTCCAGCAG	0.537000													12	63					0	0	1	0	0
NANP	140838	broad.mit.edu	37	20	25596943	25596943	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:25596943C>T	ENST00000304788.3	-	2	591	c.365G>A	c.(364-366)cGa>cAa	p.R122Q		NM_152667.2	NP_689880.1	Q8TBE9	NANP_HUMAN	N-acetylneuraminic acid phosphatase	122					N-acetylneuraminate biosynthetic process		N-acylneuraminate-9-phosphatase activity|phosphoglycolate phosphatase activity			endometrium(2)|lung(2)|prostate(1)	5						GACCTCCTTTCGAAGTTCAGT	0.433000													28	37					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371758	240371758	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:240371758G>A	ENST00000319653.9	+	5	3876	c.3646G>A	c.(3646-3648)Ggg>Agg	p.G1216R		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1216	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCCAGGTATGGGGATTCCACC	0.642000													3	6					0	0	1	0	0
HEATR6	63897	broad.mit.edu	37	17	58150574	58150574	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:58150574G>A	ENST00000184956.6	-	4	551	c.535C>T	c.(535-537)Cct>Tct	p.P179S	HEATR6_ENST00000585976.1_Missense_Mutation_p.P179S	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	179							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			CTGACTTCAGGATCAGACTGA	0.428000													22	35					0	0	1	0	0
OTUD7B	56957	broad.mit.edu	37	1	149916659	149916659	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:149916659G>A	ENST00000369135.3	-	12	1923	c.1629C>T	c.(1627-1629)agC>agT	p.S543S		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	543					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			TCTCAGTGCCGCTGCTTCCTC	0.582000													43	55					0	0	1	0	0
RPL18A	6142	broad.mit.edu	37	19	17973016	17973016	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17973016C>T	ENST00000600147.1	+	3	348	c.312C>T	c.(310-312)ggC>ggT	p.G104G	RPL18A_ENST00000599870.1_Silent_p.G75G|RPL18A_ENST00000599898.1_Silent_p.G65G|RPL18A_ENST00000222247.5_Silent_p.G104G			Q02543	RL18A_HUMAN	ribosomal protein L18a	104					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|upper_aerodigestive_tract(1)	5						CCACCGCAGGCGCTGTCACCC	0.627000													6	34					0	0	1	0	0
METTL17	64745	broad.mit.edu	37	14	21464858	21464858	+	Missense_Mutation	SNP	G	G	A	rs139452603	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:21464858G>A	ENST00000339374.6	+	13	1486	c.1253G>A	c.(1252-1254)cGc>cAc	p.R418H	METTL17_ENST00000556670.2_Missense_Mutation_p.R418H|METTL17_ENST00000382985.4_Missense_Mutation_p.R418H|RP11-84C10.4_ENST00000557335.1_RNA	NM_001029991.1|NM_022734.2	NP_001025162.1|NP_073571.1	Q9H7H0	MET17_HUMAN	methyltransferase like 17	418					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20						CTCACAGCCCGCCGGCACGGC	0.582000													20	33					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160390904	160390904	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160390904C>T	ENST00000368061.2	+	6	1474	c.1000C>T	c.(1000-1002)Cgg>Tgg	p.R334W	VANGL2_ENST00000483408.1_3'UTR	NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	334					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGCTCGGAGGCGGGACAACAG	0.577000													9	16					0	0	1	0	0
LATS1	9113	broad.mit.edu	37	6	150023045	150023045	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:150023045G>A	ENST00000543571.1	-	2	765	c.218C>T	c.(217-219)aCg>aTg	p.T73M	LATS1_ENST00000392273.3_Missense_Mutation_p.T73M|LATS1_ENST00000542747.1_5'UTR|LATS1_ENST00000253339.5_Missense_Mutation_p.T73M	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	73					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		TTTATGATGCGTCCCAAATTT	0.393000													5	137					0	0	1	0	0
C16orf80	29105	broad.mit.edu	37	16	58149205	58149205	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:58149205C>T	ENST00000262498.3	-	4	767	c.433G>A	c.(433-435)Ggc>Agc	p.G145S	C16orf80_ENST00000562443.1_5'UTR	NM_013242.2	NP_037374.1	Q9Y6A4	CP080_HUMAN	chromosome 16 open reading frame 80	145					multicellular organismal development					kidney(1)|large_intestine(1)|lung(1)|prostate(1)	4						TAATTGGTGCCGTATGCTCGC	0.547000													38	47					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204434354	204434354	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:204434354G>C	ENST00000367187.3	-	4	1583	c.1027C>G	c.(1027-1029)Ctg>Gtg	p.L343V	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.L343V	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	343					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TACATATCCAGCATGTGGCAA	0.517000													33	39					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	31007866	31007866	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:31007866G>A	ENST00000298139.5	+	31	3831	c.3582G>A	c.(3580-3582)acG>acA	p.T1194T		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	1194	HRDC.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		GACCAACTACGGTTGAAAACG	0.408000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				6	53					0	0	1	0	0
SYDE1	85360	broad.mit.edu	37	19	15222568	15222568	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:15222568C>T	ENST00000600252.1	+	3	2156	c.514C>T	c.(514-516)Cga>Tga	p.R172*	SYDE1_ENST00000600440.1_Nonsense_Mutation_p.R448*|SYDE1_ENST00000342784.2_Nonsense_Mutation_p.R515*			Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	515					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|pancreas(1)|skin(1)	17						TGAGGGCACCCGAGGGCTCCT	0.607000													7	12					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839028	128839028	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:128839028C>T	ENST00000310343.9	-	22	6037	c.6038G>A	c.(6037-6039)cGc>cAc	p.R2013H	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.R1664H|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.R1664H|ARHGAP32_ENST00000524655.1_3'UTR	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	2013	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						ACTGCTCTGGCGCTTGCCGTG	0.572000													19	22					0	0	1	0	0
PHLPP1	23239	broad.mit.edu	37	18	60646053	60646053	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:60646053C>T	ENST00000400316.4	+	17	4788	c.3007C>T	c.(3007-3009)Cgc>Tgc	p.R1003C	PHLPP1_ENST00000262719.5_Missense_Mutation_p.R1515C	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1515					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						CAGTGAGCAGCGCTGCATGCT	0.627000													4	3					0	0	1	0	0
SERPINC1	462	broad.mit.edu	37	1	173879931	173879931	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:173879931C>A	ENST00000367698.3	-	4	841	c.723G>T	c.(721-723)gaG>gaT	p.E241D		NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	241					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	GAACAGTGAGCTCATTGATGG	0.512000													39	40					6.2361e-21	6.91678e-21	1	1	0
OR4C46	119749	broad.mit.edu	37	11	51515399	51515399	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:51515399T>A	ENST00000328188.1	+	1	118	c.118T>A	c.(118-120)Tat>Aat	p.Y40N		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Y40N(1)		endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						TGTGGTGGGATATGTGCTCAT	0.453000													9	116					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100471765	100471765	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:100471765C>A	ENST00000471714.1	-	65	5070	c.4961G>T	c.(4960-4962)aGa>aTa	p.R1654I	ABI3BP_ENST00000284322.5_Missense_Mutation_p.R952I|ABI3BP_ENST00000383691.4_Missense_Mutation_p.R906I			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	952						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						ATTAAAGGGTCTTTCAGTCCA	0.378000													11	38					5.16669e-11	5.54509e-11	1	1	0
POLE	5426	broad.mit.edu	37	12	133249829	133249829	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:133249829G>A	ENST00000320574.5	-	14	1437	c.1394C>T	c.(1393-1395)gCc>gTc	p.A465V	POLE_ENST00000535270.1_Missense_Mutation_p.A438V	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	465					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GTAGTAAGTGGCGACAGCATC	0.517000								DNA polymerases (catalytic subunits)					31	44					0	0	1	0	0
TMEM67	91147	broad.mit.edu	37	8	94811976	94811976	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:94811976G>A	ENST00000453321.3	+	21	2289	c.2231G>A	c.(2230-2232)gGa>gAa	p.G744E	TMEM67_ENST00000409623.3_Missense_Mutation_p.G663E	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	744					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			CTAGCCATTGGAATTATACAG	0.363000													26	46					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100587894	100587894	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:100587894G>A	ENST00000358544.2	+	32	5144	c.5033G>A	c.(5032-5034)cGg>cAg	p.R1678Q	VPS13B_ENST00000357162.2_Missense_Mutation_p.R1653Q|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1678					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGCATACGGCGGCATCAAGAA	0.353000													51	57					0	0	1	0	0
HLA-G	3135	broad.mit.edu	37	6	29797302	29797302	+	Missense_Mutation	SNP	C	C	T	rs45530733		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:29797302C>T	ENST00000428701.1	+	5	905	c.727C>T	c.(727-729)Cgg>Tgg	p.R243W	HLA-G_ENST00000360323.6_Missense_Mutation_p.R243W|HLA-G_ENST00000376815.3_Intron|HLA-G_ENST00000376818.3_Missense_Mutation_p.R151W|HLA-G_ENST00000376828.2_Missense_Mutation_p.R248W	NM_002127.5	NP_002118.1	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	243	Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(5)|skin(1)	21						GACCTGGCAGCGGGATGGGGA	0.627000													37	47					0	0	1	0	0
MAPK1IP1L	93487	broad.mit.edu	37	14	55529374	55529374	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:55529374C>A	ENST00000395468.3	+	3	234	c.57C>A	c.(55-57)acC>acA	p.T19T	MAPK1IP1L_ENST00000554364.1_3'UTR	NM_144578.3	NP_653179.1	Q8NDC0	MISSL_HUMAN	mitogen-activated protein kinase 1 interacting protein 1-like	19										endometrium(2)|large_intestine(1)|lung(3)	6						CTGCCAAAACCTCTGCTGTGA	0.488000													12	15					2.32078e-09	2.46314e-09	1	1	0
GAREM	64762	broad.mit.edu	37	18	29850314	29850314	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:29850314T>C	ENST00000399218.4	-	5	1654	c.1599A>G	c.(1597-1599)ccA>ccG	p.P533P	GAREM_ENST00000269209.6_Silent_p.P533P	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		GTGGAACAGGTGGGGCGTTCA	0.607000													6	13					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	114118039	114118039	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:114118039A>G	ENST00000335953.4	+	6	2124	c.1744A>G	c.(1744-1746)Aag>Gag	p.K582E	RP11-64D24.2_ENST00000544925.1_RNA|ZBTB16_ENST00000535379.1_3'UTR|ZBTB16_ENST00000392996.2_Missense_Mutation_p.K582E	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	582					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		CTGTGGCAAGAAGTTCAGCCT	0.592000													3	17					0	0	1	0	0
FAM78A	286336	broad.mit.edu	37	9	134136239	134136239	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:134136239C>T	ENST00000372271.3	-	2	1189	c.822G>A	c.(820-822)ccG>ccA	p.P274P	FAM78A_ENST00000372269.3_Silent_p.P271P|FAM78A_ENST00000247295.4_5'UTR	NM_033387.3	NP_203745.2	Q5JUQ0	FA78A_HUMAN	family with sequence similarity 78, member A	274										NS(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		TCACCACCAGCGGCTGCCCGT	0.577000													8	94					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107671300	107671300	+	Missense_Mutation	SNP	G	G	A	rs145266740	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:107671300G>A	ENST00000388781.3	-	32	5026	c.4943C>T	c.(4942-4944)gCg>gTg	p.A1648V	LAMB4_ENST00000205386.4_Missense_Mutation_p.A1648V|LAMB4_ENST00000483484.1_Intron|LAMB4_ENST00000388780.3_Missense_Mutation_p.A1648V	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1648	Domain I.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CTGAACTTTCGCATTGACAGC	0.517000													55	70					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	131008675	131008675	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131008675G>T	ENST00000341179.7	+	16	1766	c.1674G>T	c.(1672-1674)gaG>gaT	p.E558D	DNM1_ENST00000486160.1_Missense_Mutation_p.E558D|DNM1_ENST00000493925.1_3'UTR|DNM1_ENST00000393594.3_Missense_Mutation_p.E558D|DNM1_ENST00000372923.3_Missense_Mutation_p.E558D|DNM1_ENST00000475805.1_Missense_Mutation_p.E558D	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	558	PH.				receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						ACCCACAGGAGAAAGAGAAGA	0.537000													10	28					3.07112e-06	3.18879e-06	1	1	0
SFMBT1	51460	broad.mit.edu	37	3	52960107	52960107	+	Silent	SNP	G	G	A	rs144071796		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52960107G>A	ENST00000394752.3	-	10	1453	c.1071C>T	c.(1069-1071)gaC>gaT	p.D357D	SFMBT1_ENST00000296295.6_Silent_p.D357D|SFMBT1_ENST00000394750.1_Silent_p.D357D|SFMBT1_ENST00000358080.2_Silent_p.D357D	NM_016329.3	NP_057413.2	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	357					regulation of transcription, DNA-dependent	nucleus				breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	24				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		AGTCAGCCCAGTCAAAGTCCT	0.592000													24	59					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108677852	108677852	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:108677852C>A	ENST00000232603.5	-	28	2997	c.2915G>T	c.(2914-2916)aGa>aTa	p.R972I	MORC1_ENST00000483760.1_Missense_Mutation_p.R951I	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	972					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						taaagggagtctatgtcttgc	0.299000													18	19					1.99824e-07	2.09433e-07	1	1	0
CCDC132	55610	broad.mit.edu	37	7	92970798	92970798	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:92970798G>A	ENST00000544910.1	+	24	2248	c.2028G>A	c.(2026-2028)gtG>gtA	p.V676V	CCDC132_ENST00000541136.1_Silent_p.V517V|CCDC132_ENST00000535481.1_Silent_p.V426V|CCDC132_ENST00000305866.5_Silent_p.V706V|CCDC132_ENST00000474412.1_3'UTR	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	706										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			AGGAGAAGGTGCCAAGTCCAC	0.448000													7	44					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74640018	74640018	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:74640018C>T	ENST00000253159.8	+	25	4742	c.4544C>T	c.(4543-4545)aCg>aTg	p.T1515M	ZNF236_ENST00000320610.9_Missense_Mutation_p.T1517M	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1515					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCCACTGCCACGTCTTCCTCG	0.522000													29	36					0	0	1	0	0
ZNF256	10172	broad.mit.edu	37	19	58454003	58454003	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58454003G>A	ENST00000598928.1	-	2	246	c.46C>T	c.(46-48)Cag>Tag	p.Q16*	ZNF256_ENST00000282308.3_Missense_Mutation_p.A58V			Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	0	KRAB.				multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		CTCATCCCCTGCTCCAGAACC	0.527000													28	37					0	0	1	0	0
OXR1	55074	broad.mit.edu	37	8	107715136	107715136	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:107715136C>T	ENST00000445937.1	+	8	939	c.678C>T	c.(676-678)ggC>ggT	p.G226G	OXR1_ENST00000517566.2_Silent_p.G226G|OXR1_ENST00000312046.6_Silent_p.G219G|OXR1_ENST00000531443.1_Silent_p.G226G|OXR1_ENST00000442977.2_Silent_p.G227G|OXR1_ENST00000452423.2_5'UTR|OXR1_ENST00000497705.1_Silent_p.G159G	NM_018002.3	NP_060472.2	Q8N573	OXR1_HUMAN	oxidation resistance 1	227	GRAM.				cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion				NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			CACCTTAGGGCACAGTCAGTG	0.343000													13	25					0	0	1	0	0
CWF19L2	143884	broad.mit.edu	37	11	107260807	107260807	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:107260807G>A	ENST00000282251.5	-	12	1892	c.1865C>T	c.(1864-1866)gCa>gTa	p.A622V	CWF19L2_ENST00000433523.1_Missense_Mutation_p.A622V	NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)	622							catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TACCTTAGATGCCATTCTCAT	0.338000													9	31					0	0	1	0	0
MKNK2	2872	broad.mit.edu	37	19	2043567	2043567	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2043567C>T	ENST00000250896.3	-	6	598	c.354G>A	c.(352-354)caG>caA	p.Q118Q	MKNK2_ENST00000541165.1_5'UTR|MKNK2_ENST00000309340.7_Silent_p.Q118Q|MKNK2_ENST00000591601.1_Silent_p.Q118Q	NM_199054.2	NP_951009.1	Q9HBH9	MKNK2_HUMAN	MAP kinase interacting serine/threonine kinase 2	118	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(3)|large_intestine(3)|lung(3)	10		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGGCCTGGCTGCTTCTCAA	0.592000													10	18					0	0	1	0	0
PDGFB	5155	broad.mit.edu	37	22	39629517	39629517	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:39629517G>A	ENST00000331163.6	-	3	960	c.173C>T	c.(172-174)gCc>gTc	p.A58V	PDGFB_ENST00000381551.4_Missense_Mutation_p.A43V	NM_002608.2	NP_002599.1	P01127	PDGFB_HUMAN	platelet-derived growth factor beta polypeptide	58					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(429)	central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)	7	Melanoma(58;0.04)				Becaplermin(DB00102)	GTCCAACTCGGCCCCATCTTC	0.637000			T	COL1A1	DFSP								8	13					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103338506	103338506	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:103338506G>T	ENST00000424685.2	-	10	1096	c.937C>A	c.(937-939)Ctc>Atc	p.L313I	RELN_ENST00000343529.5_Missense_Mutation_p.L313I|RELN_ENST00000428762.1_Missense_Mutation_p.L313I			P78509	RELN_HUMAN	reelin	313					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGAAGGTAGAGGATATGGATG	0.448000													39	65					4.0492e-12	4.37372e-12	1	1	0
ZNF574	64763	broad.mit.edu	37	19	42583593	42583593	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42583593C>T	ENST00000600245.1	+	2	1490	c.835C>T	c.(835-837)Cgc>Tgc	p.R279C	ZNF574_ENST00000359044.4_Missense_Mutation_p.R279C|ZNF574_ENST00000222339.7_Missense_Mutation_p.R369C|CTB-59C6.3_ENST00000594531.1_RNA			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R279C(1)		endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				TTACGAGCTGCGCAATGGTGA	0.647000													18	36					0	0	1	0	0
TMC6	11322	broad.mit.edu	37	17	76113374	76113374	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:76113374G>A	ENST00000590602.1	-	18	2412	c.2253C>T	c.(2251-2253)tgC>tgT	p.C751C	TMC6_ENST00000306591.7_Intron|TMC6_ENST00000591436.1_Silent_p.C330C|TMC6_ENST00000322914.3_Silent_p.C751C|TMC6_ENST00000592076.1_Intron|TMC6_ENST00000392467.3_Silent_p.C751C|TMC6_ENST00000322933.4_Silent_p.C330C			Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	751						endoplasmic reticulum membrane|integral to membrane				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	14			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CCTTGAGCAGGCAGATGACCT	0.682000													22	28					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885836	88885836	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:88885836C>T	ENST00000319675.3	-	1	460	c.364G>A	c.(364-366)Gtc>Atc	p.V122I		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	122										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						CGATTAGGGACGTAGAGGGTT	0.547000													43	48					0	0	1	0	0
GDNF	2668	broad.mit.edu	37	5	37815942	37815942	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:37815942G>A	ENST00000326524.2	-	3	646	c.447C>T	c.(445-447)tgC>tgT	p.C149C	GDNF_ENST00000381826.4_Silent_p.C140C|GDNF_ENST00000427982.1_Silent_p.C166C|GDNF_ENST00000515058.1_Silent_p.C123C|GDNF_ENST00000344622.4_Silent_p.C123C	NM_000514.3	NP_000505.1	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor	149					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity	p.C149C(1)		NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(8)|skin(2)	15	all_lung(31;0.00118)					CAGCTGCATCGCAAGAGCCGC	0.453000													38	53					0	0	1	0	0
THOC7	80145	broad.mit.edu	37	3	63820887	63820887	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:63820887G>A	ENST00000295899.5	-	7	602	c.490C>T	c.(490-492)Cgg>Tgg	p.R164W	C3orf49_ENST00000295896.8_Intron	NM_025075.2	NP_079351.2	Q6I9Y2	THOC7_HUMAN	THO complex 7 homolog (Drosophila)	164	Interaction with NIF3L1.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	cytoplasm|THO complex part of transcription export complex	protein binding|RNA binding			central_nervous_system(1)|large_intestine(1)|ovary(1)|pancreas(1)	4				BRCA - Breast invasive adenocarcinoma(55;0.000439)|Kidney(15;0.00194)|KIRC - Kidney renal clear cell carcinoma(15;0.00218)		AACTGTTTCCGTCTCAATTCC	0.308000													18	50					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77301979	77301979	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:77301979G>A	ENST00000341514.6	+	23	4570	c.4415G>A	c.(4414-4416)cGc>cAc	p.R1472H	ATP7A_ENST00000343533.5_Missense_Mutation_p.R1394H|ATP7A_ENST00000350425.4_Missense_Mutation_p.R475H	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1472					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						TCTGATAAACGCTCCCTAAAC	0.443000													96	32					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76288159	76288159	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:76288159G>A	ENST00000263187.3	+	7	1159	c.1055G>A	c.(1054-1056)cGt>cAt	p.R352H		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	352					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						AGACGACTTCGTTCTAATATA	0.333000								Mismatch excision repair (MMR)					43	74					0	0	1	0	0
FAM86HP	0	broad.mit.edu	37	3	129824431	129824431	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:129824431G>A	ENST00000500074.2	-	0	198																											CTCTGCCAGCGCCTCGTACAG	0.572000													8	12					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427790	119427790	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:119427790G>A	ENST00000369429.3	-	8	1383	c.1374C>T	c.(1372-1374)ggC>ggT	p.G458G	TBX15_ENST00000207157.3_Silent_p.G352G			Q96SF7	TBX15_HUMAN	T-box 15	458						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		TCTTGCTGTTGCCAGGCAACG	0.562000													4	34					0	0	1	0	0
SETDB1	9869	broad.mit.edu	37	1	150936118	150936118	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:150936118C>T	ENST00000271640.5	+	20	3760	c.3570C>T	c.(3568-3570)agC>agT	p.S1190S	SETDB1_ENST00000368969.4_Silent_p.S1190S	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	1190	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGGGGGAGAGCGCACCTGTTC	0.498000													44	79					0	0	1	0	0
UNC93B1	81622	broad.mit.edu	37	11	67770520	67770520	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67770520C>T	ENST00000227471.2	-	3	443	c.364G>A	c.(364-366)Gcc>Acc	p.A122T	UNC93B1_ENST00000530331.1_5'UTR	NM_030930.2	NP_112192.2	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1 (C. elegans)	122					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome											TAGAGCAGGGCGGCGATGGGA	0.627000													3	9					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64973446	64973446	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:64973446C>T	ENST00000399262.2	-	8	2699	c.2481G>A	c.(2479-2481)gcG>gcA	p.A827A	JMJD1C_ENST00000542921.1_Silent_p.A645A|JMJD1C_ENST00000402544.1_Silent_p.A608A|JMJD1C_ENST00000399251.1_Silent_p.A608A	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	827					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					GGTGTGCTAGCGCTAAGTGGC	0.498000													10	21					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204009786	204009786	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:204009786A>G	ENST00000449802.1	+	32	5453	c.5120A>G	c.(5119-5121)gAg>gGg	p.E1707G		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	1707							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GATGGTCATGAGAACATGGCA	0.328000													8	7					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47049880	47049880	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47049880C>T	ENST00000450053.3	+	51	8006	c.7827C>T	c.(7825-7827)tcC>tcT	p.S2609S	NBEAL2_ENST00000292309.5_Silent_p.S2425S|NBEAL2_ENST00000383740.2_Silent_p.S858S	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2609							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CATTGGGGTCCGAAGGCCAGA	0.597000													13	15					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57105347	57105347	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:57105347G>T	ENST00000439986.4	-	10	1020	c.983C>A	c.(982-984)tCt>tAt	p.S328Y	CCBE1_ENST00000398179.2_Missense_Mutation_p.S57Y	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	328	Collagen-like 2.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				ACTTACTGGAGACCCTCTGGG	0.517000													7	16					0.000274275	0.000279654	1	1	0
OLFM2	93145	broad.mit.edu	37	19	9965200	9965200	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9965200C>T	ENST00000264833.4	-	6	1212	c.1027G>A	c.(1027-1029)Ggc>Agc	p.G343S	OLFM2_ENST00000590841.1_Missense_Mutation_p.G265S	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	343	Olfactomedin-like.					extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						ACGATGTTGCCCGCGTTCTGG	0.642000													20	34					0	0	1	0	0
SGTA	6449	broad.mit.edu	37	19	2767626	2767626	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2767626C>T	ENST00000221566.2	-	3	320	c.159G>A	c.(157-159)gcG>gcA	p.A53A		NM_003021.3	NP_003012.1	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	53					interspecies interaction between organisms	cytoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGAGGGAGCGCAAGGTCAC	0.597000													9	21					0	0	1	0	0
GATA4	2626	broad.mit.edu	37	8	11614576	11614576	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:11614576G>T	ENST00000335135.4	+	6	1688	c.1130G>T	c.(1129-1131)aGc>aTc	p.S377I	GATA4_ENST00000528712.1_Missense_Mutation_p.S171I|GATA4_ENST00000532059.1_Missense_Mutation_p.S378I	NM_002052.3	NP_002043.2	P43694	GATA4_HUMAN	GATA binding protein 4	377			S -> G (in dbSNP:rs3729856).		atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(10)	13	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		TACGGGCACAGCAGCTCCGTG	0.652000													20	24					3.51602e-12	3.7986e-12	1	1	0
HOXB4	3214	broad.mit.edu	37	17	46655264	46655264	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:46655264C>T	ENST00000332503.5	-	1	2209	c.418G>A	c.(418-420)Gtc>Atc	p.V140I	HOXB3_ENST00000552000.2_Intron|HOXB3_ENST00000498678.1_Intron|HOXB3_ENST00000476342.1_Intron|HOXB3_ENST00000489475.1_Intron|HOXB3_ENST00000465120.3_Intron|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Intron|HOXB3_ENST00000472863.1_Intron	NM_024015.4	NP_076920.1	P17483	HXB4_HUMAN	homeobox B4	140						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	9						GGGTAGACGACGGGCTCTTTG	0.697000													11	17					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1739054	1739054	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1739054C>A	ENST00000313288.4	+	9	1941	c.1836_splice	c.e9+1	p.P612_splice		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	612						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CTGGACATTCCTGTAAGTCCT	0.517000													6	6					6.5536e-12	7.07361e-12	1	1	0
SURF6	6838	broad.mit.edu	37	9	136200595	136200595	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136200595G>A	ENST00000372022.4	-	3	617	c.352C>T	c.(352-354)Cga>Tga	p.R118*		NM_006753.4	NP_006744.2	O75683	SURF6_HUMAN	surfeit 6	118						granular component	DNA binding|RNA binding			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	12				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		AGTCGCTGTCGCAGAACATCC	0.642000													9	7					0	0	1	0	0
RGL3	57139	broad.mit.edu	37	19	11527672	11527672	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11527672C>A	ENST00000380456.3	-	3	272	c.209G>T	c.(208-210)aGg>aTg	p.R70M	RGL3_ENST00000393423.3_Missense_Mutation_p.R70M	NM_001035223.2|NM_001161616.1	NP_001030300.2|NP_001155088.1	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation stimulator-like 3	70	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				breast(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(1)|skin(1)	18						GCGCGCTGCCCTCAGCACCCT	0.632000													4	10					0.000602214	0.000612743	1	1	0
LDOC1L	84247	broad.mit.edu	37	22	44892880	44892880	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:44892880C>T	ENST00000341255.3	-	2	1066	c.557G>A	c.(556-558)cGc>cAc	p.R186H		NM_032287.2	NP_115663.2	Q6ICC9	LDOCL_HUMAN	leucine zipper, down-regulated in cancer 1-like	186										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(3)|prostate(2)	11		Ovarian(80;0.024)|all_neural(38;0.0416)		LUAD - Lung adenocarcinoma(64;0.0161)		GATTTGGGCGCGCCGCGCATG	0.627000													6	6					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122433212	122433212	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:122433212C>A	ENST00000474629.2	+	12	4202	c.3936C>A	c.(3934-3936)tcC>tcA	p.S1312S		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1312	Macro 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		GTTCAGTTTCCTCTGTTTTGC	0.418000													10	13					3.86212e-05	3.97146e-05	1	1	0
CDC7	8317	broad.mit.edu	37	1	91978651	91978651	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:91978651C>T	ENST00000428239.1	+	7	868	c.609C>T	c.(607-609)acC>acT	p.T203T	CDC7_ENST00000430031.2_Silent_p.T175T|CDC7_ENST00000234626.6_Silent_p.T203T	NM_001134420.1	NP_001127892.1	O00311	CDC7_HUMAN	cell division cycle 7	203	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|stomach(2)	23		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		CCCAAGGAACCCATGATACGA	0.363000													28	37					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14619487	14619487	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:14619487C>A	ENST00000544627.1	+	10	3169	c.2849C>A	c.(2848-2850)gCt>gAt	p.A950D	ATF7IP_ENST00000543189.1_Missense_Mutation_p.A941D|ATF7IP_ENST00000536444.1_Missense_Mutation_p.A941D|ATF7IP_ENST00000540793.1_Missense_Mutation_p.A942D|ATF7IP_ENST00000261168.4_Missense_Mutation_p.A942D			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	942					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						ACAATAGATGCTTCTGTCAGT	0.294000													16	33					2.94398e-08	3.10271e-08	1	1	0
THAP7-AS1	0	broad.mit.edu	37	22	21363307	21363307	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:21363307C>T	ENST00000452284.1	+	0	974				THAP7-AS1_ENST00000436079.1_RNA|TUBA3FP_ENST00000422086.1_RNA	NR_027051.1																						ATGACCAGGGCGTAGGTGGCC	0.582000													11	45					0	0	1	0	0
HDAC1	3065	broad.mit.edu	37	1	32793220	32793220	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32793220T>C	ENST00000373548.3	+	6	662	c.578T>C	c.(577-579)gTc>gCc	p.V193A	HDAC1_ENST00000490081.1_3'UTR|HDAC1_ENST00000373541.2_5'UTR	NM_004964.2	NP_004955.2	Q13547	HDAC1_HUMAN	histone deacetylase 1	193	Histone deacetylase.				anti-apoptosis|blood coagulation|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytosol|NuRD complex|Sin3 complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)	ACGGACCGGGTCATGACTGTG	0.542000													13	44					0	0	1	0	0
CDK14	5218	broad.mit.edu	37	7	90356036	90356036	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:90356036G>A	ENST00000406263.1	+	2	583	c.141G>A	c.(139-141)gtG>gtA	p.V47V	CDK14_ENST00000436577.2_5'UTR|CDK14_ENST00000265741.3_Silent_p.V75V|CDK14_ENST00000380050.3_Silent_p.V93V			O94921	CDK14_HUMAN	cyclin-dependent kinase 14	93					cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(12)|ovary(1)|skin(4)	32						TAAAGAGGGTGCATTCTGAGA	0.468000													25	34					0	0	1	0	0
TBCCD1	55171	broad.mit.edu	37	3	186272347	186272347	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:186272347C>T	ENST00000424280.1	-	6	1719	c.1240G>A	c.(1240-1242)Gta>Ata	p.V414I	TBCCD1_ENST00000338733.5_Missense_Mutation_p.V414I|TBCCD1_ENST00000446782.1_Missense_Mutation_p.V318I	NM_001134415.1	NP_001127887.1	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	414	C-CAP/cofactor C-like.				cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|skin(1)	17	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		GCAAAAGTTACTGTCTGGTTC	0.463000													10	16					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2443516	2443516	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:2443516C>T	ENST00000452833.1	-	2	161	c.153G>A	c.(151-153)gtG>gtA	p.V51V	TRPM5_ENST00000528453.1_Silent_p.V51V|TRPM5_ENST00000533060.1_Silent_p.V51V|TRPM5_ENST00000155858.6_Silent_p.V51V			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	51						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGTCAAAGAGCACAGACGGGG	0.657000													11	20					0	0	1	0	0
CTH	1491	broad.mit.edu	37	1	70904388	70904388	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:70904388C>T	ENST00000411986.2	+	10	1172	c.974C>T	c.(973-975)gCa>gTa	p.A325V	CTH_ENST00000346806.2_Missense_Mutation_p.A313V|CTH_ENST00000370938.3_Missense_Mutation_p.A357V	NM_001190463.1	NP_001177392.1	P32929	CGL_HUMAN	cystathionase (cystathionine gamma-lyase)	357					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	ATGACTCATGCATCAGTTCTT	0.408000													25	50					0	0	1	0	0
INTS3	65123	broad.mit.edu	37	1	153719758	153719758	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:153719758G>A	ENST00000318967.2	+	5	1004	c.436G>A	c.(436-438)Gtg>Atg	p.V146M	INTS3_ENST00000456435.1_5'UTR|RP11-216N14.8_ENST00000453778.1_RNA|INTS3_ENST00000435409.2_Missense_Mutation_p.V146M	NM_023015.3	NP_075391.3	Q68E01	INT3_HUMAN	integrator complex subunit 3	146					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCTTTAGTTGGTGTGGTTGGT	0.448000													24	15					0	0	1	0	0
TCF7L1	83439	broad.mit.edu	37	2	85510659	85510659	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:85510659C>T	ENST00000282111.3	+	4	758	c.483C>T	c.(481-483)agC>agT	p.S161S		NM_031283.2	NP_112573.1	Q9HCS4	TF7L1_HUMAN	transcription factor 7-like 1 (T-cell specific, HMG-box)	161	Pro-rich.				chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(4)|upper_aerodigestive_tract(1)	18						TCCCCTCCAGCGCCACAGTCA	0.517000													47	81					0	0	1	0	0
IRF5	3663	broad.mit.edu	37	7	128587975	128587975	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128587975G>A	ENST00000402030.2	+	7	1004	c.932G>A	c.(931-933)cGc>cAc	p.R311H	IRF5_ENST00000477535.1_Missense_Mutation_p.R225H|IRF5_ENST00000357234.5_Missense_Mutation_p.R327H|IRF5_ENST00000249375.4_Missense_Mutation_p.R311H|IRF5_ENST00000473745.1_Missense_Mutation_p.R311H	NM_001098629.1|NM_001098630.1	NP_001092099.1|NP_001092100.1	Q13568	IRF5_HUMAN	interferon regulatory factor 5	311					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(1)|prostate(1)	15						GACAAGCAGCGCTTCTACACG	0.622000													14	26					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128302176	128302176	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:128302176C>T	ENST00000262462.4	+	1	1356	c.346C>T	c.(346-348)Ccg>Tcg	p.P116S	SLC27A6_ENST00000395266.1_Missense_Mutation_p.P116S|SLC27A6_ENST00000506176.1_Missense_Mutation_p.P116S			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	116					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GAGCAATGAGCCGGACTTCGT	0.557000													15	15					0	0	1	0	0
CHD1	1105	broad.mit.edu	37	5	98195690	98195690	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:98195690G>A	ENST00000284049.3	-	32	4659	c.4510C>T	c.(4510-4512)Cgg>Tgg	p.R1504W		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1504					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	GACTCCTGCCGTTTTTTAATA	0.264000													14	28					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20598243	20598243	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:20598243G>A	ENST00000504154.1	+	32	3778	c.3526G>A	c.(3526-3528)Gcc>Acc	p.A1176T	SLIT2_ENST00000503837.1_Missense_Mutation_p.A1172T|SLIT2_ENST00000503823.1_Missense_Mutation_p.A1168T|SLIT2_ENST00000273739.5_Missense_Mutation_p.A1189T	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1176	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GATTCCTTCAGCCAAGGTTCG	0.388000													18	19					0	0	1	0	0
BOLL	66037	broad.mit.edu	37	2	198640396	198640396	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:198640396C>T	ENST00000321801.7	-	5	951	c.381G>A	c.(379-381)ggG>ggA	p.G127G	BOLL_ENST00000433157.1_Silent_p.G115G|BOLL_ENST00000392296.4_Silent_p.G115G|BOLL_ENST00000430004.1_Silent_p.G115G|BOLL_ENST00000282278.8_Intron	NM_197970.2	NP_932074.1	Q8N9W6	BOLL_HUMAN	boule-like RNA-binding protein	115					cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity	p.G115G(1)|p.G127G(1)		central_nervous_system(1)|endometrium(2)|lung(6)|ovary(3)|prostate(1)	13						TACGAGGGATCCCTACTTGTT	0.249000													23	67					0	0	1	0	0
OLA1	29789	broad.mit.edu	37	2	175094087	175094087	+	Translation_Start_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:175094087G>T	ENST00000344357.5	-	0	240				OLA1_ENST00000409546.1_Missense_Mutation_p.P85H|OLA1_ENST00000428402.2_Missense_Mutation_p.P65H|OLA1_ENST00000284719.3_Missense_Mutation_p.P65H	NM_001011708.1	NP_001011708.1	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1						ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11						ATCTGGCACAGGTACTCTGCT	0.378000													16	31					2.5808e-16	2.83426e-16	1	1	0
TRAC	0	broad.mit.edu	37	14	23020994	23020994	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23020994C>T	ENST00000478163.3	+	0	871																											CTTCTCAAGACGTGGGGGGAA	0.433000													18	26					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150654454	150654454	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150654454C>T	ENST00000392968.2	-	3	1885	c.765G>A	c.(763-765)tcG>tcA	p.S255S	KCNH2_ENST00000262186.5_Silent_p.S351S|KCNH2_ENST00000430723.3_Silent_p.S351S			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	351					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CACTGGTGGGCGAAGCCAAGA	0.587000													5	8					0	0	1	0	0
EPHX3	79852	broad.mit.edu	37	19	15342604	15342604	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:15342604G>A	ENST00000221730.3	-	2	532	c.312C>T	c.(310-312)caC>caT	p.H104H	EPHX3_ENST00000435261.1_Silent_p.H104H|EPHX3_ENST00000602233.1_Silent_p.H104H	NM_024794.2	NP_079070.1	Q9H6B9	EPHX3_HUMAN	epoxide hydrolase 3	104						extracellular region	hydrolase activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						CAGGGAAGCCGTGCAGAAACA	0.667000													11	22					0	0	1	0	0
PROK2	60675	broad.mit.edu	37	3	71830692	71830692	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:71830692T>C	ENST00000353065.3	-	2	301	c.148A>G	c.(148-150)Atc>Gtc	p.I50V	PROK2_ENST00000295619.3_Missense_Mutation_p.I50V	NM_021935.3	NP_068754.1	Q9HC23	PROK2_HUMAN	prokineticin 2	50					activation of MAPK activity|angiogenesis|anti-apoptosis|cell proliferation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response|neuropeptide signaling pathway|positive regulation of smooth muscle contraction|sensory perception of pain|spermatogenesis	extracellular region	G-protein-coupled receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.89e-05)|Epithelial(33;0.000173)|LUSC - Lung squamous cell carcinoma(21;0.00168)|Lung(16;0.00306)		TTGACCCAGATACTGACAGCA	0.408000													18	36					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21128018	21128018	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:21128018T>C	ENST00000269228.5	-	11	2263	c.1709A>G	c.(1708-1710)tAc>tGc	p.Y570C	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Intron	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	570					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ATCATTATAGTAATTATTGAC	0.438000													27	114					0	0	1	0	0
MAP4K2	5871	broad.mit.edu	37	11	64569094	64569094	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64569094C>A	ENST00000294066.2	-	7	506		c.e7-1		MAP4K2_ENST00000468062.1_Intron|MAP4K2_ENST00000377350.3_Splice_Site	NM_004579.3	NP_004570.2	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase kinase 2						activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2)	8						GGTTGGCTCCCTGTGGGAATG	0.627000													19	25					1.01871e-10	1.09092e-10	1	1	0
KRBA1	84626	broad.mit.edu	37	7	149416750	149416750	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149416750G>A	ENST00000255992.10	+	2	420	c.21G>A	c.(19-21)acG>acA	p.T7T	KRBA1_ENST00000319551.8_Silent_p.T7T|KRBA1_ENST00000485033.2_Silent_p.T7T|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	7										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACTACGAGACGCTGGTCTCTG	0.657000													14	14					0	0	1	0	0
PYCR1	5831	broad.mit.edu	37	17	79892848	79892848	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79892848T>A	ENST00000337943.5	-	4	936	c.494A>T	c.(493-495)gAc>gTc	p.D165V	PYCR1_ENST00000577756.1_Missense_Mutation_p.D165V|PYCR1_ENST00000329875.8_Missense_Mutation_p.D165V|PYCR1_ENST00000402252.2_Missense_Mutation_p.D192V|PYCR1_ENST00000403172.4_Missense_Mutation_p.D165V	NM_153824.1	NP_722546.1	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1	165					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity			endometrium(2)|kidney(1)|lung(1)|prostate(1)	5	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	ATCAATCAGGTCCTCTTCCAC	0.697000													7	23					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49656894	49656894	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49656894T>C	ENST00000252825.4	-	1	1787	c.1601A>G	c.(1600-1602)gAg>gGg	p.E534G	HRC_ENST00000595625.1_Missense_Mutation_p.E534G	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	534					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		ctcttcttcctcctcctGGTT	0.597000													7	17					0	0	1	0	0
PLOD1	5351	broad.mit.edu	37	1	12020809	12020809	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12020809C>G	ENST00000196061.4	+	10	1109	c.1082C>G	c.(1081-1083)gCc>gGc	p.A361G	PLOD1_ENST00000376369.3_Missense_Mutation_p.A408G	NM_000302.3	NP_000293.2	Q02809	PLOD1_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	361					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	AATGCAGATGCCAGGAACATG	0.612000													11	23					0	0	1	0	0
FHL5	9457	broad.mit.edu	37	6	97051589	97051589	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:97051589G>A	ENST00000326771.2	+	3	480	c.100G>A	c.(100-102)Gat>Aat	p.D34N	FHL5_ENST00000541107.1_Missense_Mutation_p.D34N	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5	34						nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TACATGTTATGATCGTGTATT	0.358000													39	52					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41129556	41129556	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41129556G>A	ENST00000308370.7	+	29	3802	c.3802G>A	c.(3802-3804)Gtg>Atg	p.V1268M	LTBP4_ENST00000243562.9_3'UTR|LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000204005.9_Missense_Mutation_p.V1231M|LTBP4_ENST00000396819.3_Missense_Mutation_p.V1201M|LTBP4_ENST00000545697.1_Missense_Mutation_p.V636M	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1269	EGF-like 13; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CAAGAGTGGCGTGTGTGTGAA	0.597000													8	14					0	0	1	0	0
PCDHGA10	0	broad.mit.edu	37	5	140795118	140795118	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140795118C>T	ENST00000398610.2	+	1	2376	c.2376C>T	c.(2374-2376)aaC>aaT	p.N792N	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAGAAAAACGATCCTTTGT	0.433000													28	40					0	0	1	0	0
FAM160B2	64760	broad.mit.edu	37	8	21960311	21960311	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:21960311C>T	ENST00000289921.7	+	17	2147	c.2101C>T	c.(2101-2103)Cac>Tac	p.H701Y		NM_022749.5	NP_073586.5	Q86V87	F16B2_HUMAN	family with sequence similarity 160, member B2	701										endometrium(2)|kidney(1)|lung(2)|prostate(3)|urinary_tract(1)	9						CAGGCTGGACCACCAGACCCT	0.642000													15	35					0	0	1	0	0
COPB2	9276	broad.mit.edu	37	3	139085507	139085507	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:139085507G>A	ENST00000333188.5	-	15	1968	c.1787C>T	c.(1786-1788)aCa>aTa	p.T596I	COPB2_ENST00000507777.1_Missense_Mutation_p.T567I	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	596					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						CATGACAGCTGTCTGGTATTC	0.453000													34	38					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	4007994	4007994	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4007994C>T	ENST00000381638.2	-	8	1630	c.1506G>A	c.(1504-1506)acG>acA	p.T502T	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	502							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CATCATACTGCGTGTCCAGAT	0.478000													18	20					0	0	1	0	0
ZNF112	7665	broad.mit.edu	37	19	44831640	44831640	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44831640C>T	ENST00000354340.4	-	4	2721	c.2670G>A	c.(2668-2670)aaG>aaA	p.K890K	ZNF112_ENST00000337401.4_Silent_p.K896K|ZNF112_ENST00000536500.1_Silent_p.K913K	NM_013380.3	NP_037512.3			zinc finger protein 112																		AAGGGTAGTCCTTACCATAGT	0.393000													20	35					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139907310	139907310	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139907310C>T	ENST00000265662.5	-	31	5082	c.4935G>A	c.(4933-4935)gcG>gcA	p.A1645A	ABCA2_ENST00000371605.3_Silent_p.A1644A|ABCA2_ENST00000341511.6_Silent_p.A1645A			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1644					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGGTGCCCTGCGCAGAGCAGG	0.687000													7	3					0	0	1	0	0
HSPA12A	259217	broad.mit.edu	37	10	118440767	118440767	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118440767C>T	ENST00000369209.3	-	9	1027	c.922_splice	c.e9-1	p.G308_splice		NM_025015.2	NP_079291.2	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	308							ATP binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32				all cancers(201;0.0158)		ATACTTATCACCTGGCACAAA	0.498000													23	29					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29737722	29737722	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:29737722G>A	ENST00000357586.2	-	13	1750	c.1564C>T	c.(1564-1566)Cgt>Tgt	p.R522C	AP1B1_ENST00000432560.2_Missense_Mutation_p.R522C|AP1B1_ENST00000415447.1_Missense_Mutation_p.R522C|AP1B1_ENST00000356015.2_Missense_Mutation_p.R522C|AP1B1_ENST00000402502.1_Missense_Mutation_p.R522C|AP1B1_ENST00000405198.1_Missense_Mutation_p.R522C|AP1B1_ENST00000317368.7_Missense_Mutation_p.R522C	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	522					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						ATGTAGCCACGGTCCCGCAGG	0.592000													5	11					0	0	1	0	0
SEPN1	57190	broad.mit.edu	37	1	26135154	26135154	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26135154G>A	ENST00000361547.2	+	5	676	c.621G>A	c.(619-621)caG>caA	p.Q207Q	SEPN1_ENST00000354177.4_Silent_p.Q173Q|SEPN1_ENST00000374315.1_Silent_p.Q173Q	NM_020451.2	NP_065184.2	Q9NZV5	SELN_HUMAN	selenoprotein N, 1	207						endoplasmic reticulum membrane|extracellular region	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		GCCACTTCCAGCCCTTCCTTC	0.657000													19	33					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27670411	27670411	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27670411G>A	ENST00000260570.3	-	42	4733	c.4630C>T	c.(4630-4632)Cgc>Tgc	p.R1544C		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1544					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GCTGCAGAGCGCGTGGCATAG	0.507000													53	58					0	0	1	0	0
CKAP4	10970	broad.mit.edu	37	12	106633671	106633671	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:106633671G>T	ENST00000378026.4	-	2	1076	c.940C>A	c.(940-942)Ctt>Att	p.L314I	CKAP4_ENST00000552828.1_Intron	NM_006825.3	NP_006816.2	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	314						ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction				NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|pancreas(1)|urinary_tract(1)	20						ATAGTCTGAAGGGTACTTCTC	0.567000													20	32					2.94398e-08	3.10271e-08	1	1	0
MIR190B	0	broad.mit.edu	37	1	154166159	154166159	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154166159G>A	ENST00000401119.1	-	0	60					NR_030600.1																						GTAAGAATATGTTTGACATTT	0.458000													16	23					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64678120	64678120	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64678120G>A	ENST00000421419.2	-	12	1789	c.1675C>T	c.(1675-1677)Cgc>Tgc	p.R559C	ATG2A_ENST00000377264.3_Missense_Mutation_p.R559C			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	559							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						TGTGTGTGGCGCAGATGGGCG	0.682000													3	4					0	0	1	0	0
IQCG	84223	broad.mit.edu	37	3	197619592	197619592	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:197619592G>A	ENST00000265239.6	-	10	1426	c.1002C>T	c.(1000-1002)taC>taT	p.Y334Y	IQCG_ENST00000455191.1_Silent_p.Y334Y	NM_032263.3	NP_115639.1	Q9H095	IQCG_HUMAN	IQ motif containing G	334										autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		TGTCCTTATCGTATTTCTCCA	0.418000													52	81					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19318461	19318461	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:19318461G>A	ENST00000461366.1	+	11	1452	c.1237G>A	c.(1237-1239)Gcc>Acc	p.A413T		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	413							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						CGAGGGGCGCGCCGTGGCCAG	0.662000													10	38					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38933358	38933358	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:38933358G>A	ENST00000274276.3	+	18	3154	c.2752G>A	c.(2752-2754)Gtg>Atg	p.V918M		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	918					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					TTTGAATTATGTGTCCCAGTT	0.443000													8	79					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123927349	123927349	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:123927349A>G	ENST00000373855.1	+	35	5812	c.5552A>G	c.(5551-5553)gAc>gGc	p.D1851G	CNTRL_ENST00000373845.2_3'UTR|CNTRL_ENST00000373850.1_Missense_Mutation_p.D1299G|CNTRL_ENST00000238341.5_Missense_Mutation_p.D1851G			Q7Z7A1	CNTRL_HUMAN	centriolin	1851					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						CTGCATAACGACATTTCAGCA	0.393000													3	47					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64410041	64410041	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64410041G>A	ENST00000301894.2	-	1	746	c.235C>T	c.(235-237)Cgc>Tgc	p.R79C	NRXN2_ENST00000409571.1_Intron|NRXN2_ENST00000377551.1_Intron|NRXN2_ENST00000377559.3_Intron|NRXN2_ENST00000265459.6_Intron	NM_138734.2	NP_620063.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	0	Laminin G-like 1.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						AAGGGCATGCGGTTGATGGCG	0.726000													6	12					0	0	1	0	0
WWOX	51741	broad.mit.edu	37	16	78143685	78143685	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:78143685C>T	ENST00000566780.1	+	3	549	c.183C>T	c.(181-183)taC>taT	p.Y61Y	WWOX_ENST00000402655.2_Silent_p.Y61Y|WWOX_ENST00000406884.2_Silent_p.Y61Y|WWOX_ENST00000539474.2_Silent_p.Y61Y|WWOX_ENST00000408984.3_Silent_p.Y61Y|WWOX_ENST00000355860.3_Silent_p.Y61Y	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	61	WW 2.				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		ATTTGCCATACGGATGGGAAC	0.468000													28	38					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123122202	123122202	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:123122202G>A	ENST00000264501.4	+	15	1792	c.1419G>A	c.(1417-1419)atG>atA	p.M473I	KIAA1109_ENST00000495260.1_3'UTR|KIAA1109_ENST00000455637.1_Missense_Mutation_p.M473I|KIAA1109_ENST00000388738.3_Missense_Mutation_p.M473I			Q2LD37	K1109_HUMAN	KIAA1109	473					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TATGGAACATGCCGCAGACAT	0.373000													22	24					0	0	1	0	0
IGHV1OR21-1	0	broad.mit.edu	37	21	10862625	10862625	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:10862625G>A	ENST00000559480.1	+	0	4																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						CCTTACCATGGACTGGAATTG	0.493000													31	198					0	0	1	0	0
CRHR2	1395	broad.mit.edu	37	7	30705216	30705216	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:30705216C>T	ENST00000471646.1	-	4	772	c.355G>A	c.(355-357)Gtc>Atc	p.V119I	CRHR2_ENST00000348438.4_Missense_Mutation_p.V146I|CRHR2_ENST00000341843.4_Missense_Mutation_p.V105I|CRHR2_ENST00000506074.2_Missense_Mutation_p.V119I	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	119					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						AGGTAGTTGACGACAAGGGCG	0.632000													3	5					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71431641	71431641	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:71431641G>A	ENST00000392650.3	-	9	1143	c.1143C>T	c.(1141-1143)ttC>ttT	p.F381F	SDK2_ENST00000388726.3_Silent_p.F381F	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	381	Ig-like C2-type 4.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						CATTGCGGGCGAAGCACTGGA	0.637000													6	7					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10291513	10291513	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10291513C>A	ENST00000340748.4	-	3	401	c.166G>T	c.(166-168)Gaa>Taa	p.E56*	DNMT1_ENST00000359526.4_Nonsense_Mutation_p.E56*|DNMT1_ENST00000540357.1_Nonsense_Mutation_p.E56*			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	56	Interaction with DMAP1.|Interaction with DNMT3A.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TTCTTTATTTCTGTTTGCAGA	0.378000													5	30					0.000602214	0.000612743	1	1	0
CYP4F22	126410	broad.mit.edu	37	19	15662225	15662225	+	Silent	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:15662225A>T	ENST00000269703.2	+	14	1738	c.1539A>T	c.(1537-1539)atA>atT	p.I513I	CYP4F22_ENST00000601005.2_Silent_p.I513I	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	513						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						CGGAGCTCATACTGCGCACGG	0.706000													5	9					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103191624	103191624	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:103191624G>A	ENST00000424685.2	-	41	6351	c.6192C>T	c.(6190-6192)caC>caT	p.H2064H	RELN_ENST00000343529.5_Silent_p.H2064H|RELN_ENST00000428762.1_Silent_p.H2064H			P78509	RELN_HUMAN	reelin	2064					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AAGAGCTGACGTGGCTGCTGC	0.602000													12	17					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458151	248458151	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:248458151C>G	ENST00000317996.1	-	1	729	c.730G>C	c.(730-732)Gct>Cct	p.A244P		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CCCACCACAGCCACATGTGAA	0.512000													12	55					0	0	1	0	0
GLIPR1L1	256710	broad.mit.edu	37	12	75728642	75728642	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:75728642G>A	ENST00000312442.2	+	1	180	c.134G>A	c.(133-135)cGt>cAt	p.R45H	GLIPR1L1_ENST00000378695.4_Missense_Mutation_p.R45H|CAPS2_ENST00000442339.2_Intron	NM_152779.2	NP_689992.1	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	45						extracellular region				endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	10						AACGAATGGCGTGGCAAAGTC	0.498000											OREG0021998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	31					0	0	1	0	0
ZFP57	346171	broad.mit.edu	37	6	29641216	29641216	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:29641216C>T	ENST00000376883.1	-	6	1023	c.612G>A	c.(610-612)atG>atA	p.M204I	ZFP57_ENST00000376881.3_Missense_Mutation_p.M204I|ZFP57_ENST00000488757.1_Missense_Mutation_p.M224I			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	140					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						CCCCAAGATGCATGCGTCTGT	0.547000													27	44					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102472454	102472454	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:102472454C>T	ENST00000321521.9	+	4	902	c.329C>T	c.(328-330)gCg>gTg	p.A110V	PPIP5K2_ENST00000414217.1_Missense_Mutation_p.A110V|PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000358359.3_Missense_Mutation_p.A110V			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	110					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CTGGACAAAGCGGTTGCCTAT	0.353000													51	82					0	0	1	0	0
FGFR1OP2	26127	broad.mit.edu	37	12	27109595	27109595	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:27109595T>C	ENST00000229395.3	+	3	595		c.e3+2		FGFR1OP2_ENST00000546072.1_Splice_Site|FGFR1OP2_ENST00000327214.5_Splice_Site	NM_015633.2	NP_056448.1	Q9NVK5	FGOP2_HUMAN	FGFR1 oncogene partner 2							cytoplasm				cervix(1)|large_intestine(4)|lung(1)|prostate(2)	8	Colorectal(261;0.0847)					AAAACAAAGGTAAGATACGTT	0.388000													17	40					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134896280	134896280	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:134896280C>T	ENST00000607359.1	+	7	1292	c.1292C>T	c.(1291-1293)cCc>cTc	p.P431L				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GTGCCGTCCCCCTGTAAGCCT	0.662000													3	8					0	0	1	0	0
TGFBR3	7049	broad.mit.edu	37	1	92193276	92193276	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:92193276G>A	ENST00000212355.4	-	7	1290	c.825C>T	c.(823-825)tgC>tgT	p.C275C	TGFBR3_ENST00000370399.2_Silent_p.C275C|TGFBR3_ENST00000525962.1_Silent_p.C275C	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	275					BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		CAGACTTTTTGCACTTCAAGA	0.363000													33	35					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	623584	623584	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:623584G>A	ENST00000588649.2	-	6	1244	c.1160C>T	c.(1159-1161)cCg>cTg	p.P387L	LLNLR-299G3.1_ENST00000607288.1_RNA	NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	387					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCAGCTTCGGGTAGGACAC	0.647000													9	13					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18923680	18923680	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18923680T>C	ENST00000317977.6	+	15	2208	c.1637T>C	c.(1636-1638)gTc>gCc	p.V546A	SLC5A10_ENST00000395645.3_Missense_Mutation_p.V576A|SLC5A10_ENST00000417251.2_Missense_Mutation_p.V540A|SLC5A10_ENST00000395642.1_Missense_Mutation_p.V546A|SLC5A10_ENST00000395643.2_Missense_Mutation_p.V549A|SLC5A10_ENST00000395647.2_Missense_Mutation_p.V592A			A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	576					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						TGGGCCCGTGTCTGTGGCTTC	0.542000													4	74					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	333659	333659	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:333659C>T	ENST00000343164.4	-	10	1133	c.1081G>A	c.(1081-1083)Gct>Act	p.A361T	SLC6A13_ENST00000445055.2_Missense_Mutation_p.A269T	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	361					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CGCGGGTAAGCGATGAAAGCC	0.622000													4	25					0	0	1	0	0
ZNF250	58500	broad.mit.edu	37	8	146107193	146107193	+	Missense_Mutation	SNP	G	G	A	rs141960807		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:146107193G>A	ENST00000292579.7	-	6	1506	c.1390C>T	c.(1390-1392)Cgg>Tgg	p.R464W	ZNF250_ENST00000543949.1_Intron|ZNF250_ENST00000342660.6_Intron|ZNF250_ENST00000417550.2_Missense_Mutation_p.R459W	NM_001109689.3|NM_021061.4	NP_001103159.1|NP_066405.1	P15622	ZN250_HUMAN	zinc finger protein 250	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(2)|lung(8)|skin(1)	15	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		ATCAGAGACCGGCGTGCACTG	0.547000													16	18					0	0	1	0	0
PCDHA11	0	broad.mit.edu	37	5	140250647	140250647	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140250647C>T	ENST00000398640.2	+	1	1959	c.1959C>T	c.(1957-1959)caC>caT	p.H653H	PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAGGATCACGGTGAGCCGG	0.677000													25	31					0	0	1	0	0
DUSP14	11072	broad.mit.edu	37	17	35872544	35872544	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:35872544T>C	ENST00000487847.1	+	2	1148	c.170T>C	c.(169-171)gTt>gCt	p.V57A	DUSP14_ENST00000394386.1_Missense_Mutation_p.V57A|DUSP14_ENST00000394389.4_Missense_Mutation_p.V57A			O95147	DUS14_HUMAN	dual specificity phosphatase 14	57							MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|urinary_tract(1)	9		Breast(25;0.00637)|Ovarian(249;0.15)				ACCTGCATTGTTAATGCTACC	0.512000													28	34					0	0	1	0	0
U2AF2	11338	broad.mit.edu	37	19	56170636	56170636	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56170636G>A	ENST00000450554.2	+	2	1069	c.110G>A	c.(109-111)cGc>cAc	p.R37H	U2AF2_ENST00000308924.4_Missense_Mutation_p.R37H	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2	37	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		AGCCGGGACCGCAAACGCCGG	0.711000													5	10					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169492481	169492481	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:169492481T>G	ENST00000367796.3	-	21	6218	c.6017A>C	c.(6016-6018)cAg>cCg	p.Q2006P	F5_ENST00000367797.3_Missense_Mutation_p.Q2001P			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	2001	F5/8 type C 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCAGTTGATCTGGTTGGAACT	0.433000													30	32					0	0	1	0	0
TMEM165	55858	broad.mit.edu	37	4	56284135	56284135	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:56284135G>A	ENST00000381334.5	+	4	1008	c.775G>A	c.(775-777)Gta>Ata	p.V259I	TMEM165_ENST00000506198.1_Intron|TMEM165_ENST00000514904.1_3'UTR|TMEM165_ENST00000542052.1_Missense_Mutation_p.V196I	NM_018475.3	NP_060945.2	Q9HC07	TM165_HUMAN	transmembrane protein 165	259						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)	4	Lung NSC(11;0.00545)|Glioma(25;0.08)|all_neural(26;0.101)|all_epithelial(27;0.135)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0103)			AACTACAATTGTATTGGCAGC	0.358000													52	69					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45789573	45789573	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:45789573G>A	ENST00000357450.4	-	9	1485	c.1486C>T	c.(1486-1488)Cgt>Tgt	p.R496C	SMC1B_ENST00000404354.3_Missense_Mutation_p.R496C	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	496	Flexible hinge.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TTTTGCTGACGTTTTCCCTCA	0.328000													9	69					0	0	1	0	0
GPR21	2844	broad.mit.edu	37	9	125797091	125797091	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:125797091C>T	ENST00000373642.1	+	1	286	c.246C>T	c.(244-246)tgC>tgT	p.C82C	RABGAP1_ENST00000373643.5_Intron|RABGAP1_ENST00000493854.1_Intron|RABGAP1_ENST00000373647.4_Intron	NM_005294.1	NP_005285.1	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	82						integral to plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	15						GGGTGAGCTGCGTGGTCCCTT	0.433000													27	35					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144911932	144911932	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:144911932C>A	ENST00000529945.1	-	12	3105	c.2666G>T	c.(2665-2667)aGc>aTc	p.S889I	PDE4DIP_ENST00000530740.1_Missense_Mutation_p.S863I|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.S889I|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.S726I|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.S726I|PDE4DIP_ENST00000369359.4_Missense_Mutation_p.S863I|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.S513I|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.S792I|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.S726I|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.S726I			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	726					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAATGAAGTGCTATCATCTCT	0.383000			T	PDGFRB	MPD								26	139					1.08312e-15	1.18619e-15	1	1	0
ANKRD26	22852	broad.mit.edu	37	10	27326939	27326939	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:27326939G>A	ENST00000376087.4	-	22	2585	c.2420C>T	c.(2419-2421)aCg>aTg	p.T807M	ANKRD26_ENST00000376070.3_Missense_Mutation_p.T364M|ANKRD26_ENST00000436985.2_Missense_Mutation_p.T823M	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	806						centrosome		p.T807M(1)		breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						TTCATACAACGTATCAGCATT	0.308000													27	26					0	0	1	0	0
ATP6V1A	523	broad.mit.edu	37	3	113514787	113514787	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:113514787G>A	ENST00000273398.3	+	11	1398		c.e11+1		ATP6V1A_ENST00000538620.1_Splice_Site	NM_001690.3	NP_001681.2	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TATCGTTCAGGTATGTCTTTC	0.378000													16	39					0	0	1	0	0
PILRB	29990	broad.mit.edu	37	7	99956438	99956438	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99956438G>A	ENST00000310771.4	+	16	2686	c.190G>A	c.(190-192)Gtt>Att	p.V64I	PILRB_ENST00000444073.1_Missense_Mutation_p.V64I|PILRB_ENST00000452089.1_Missense_Mutation_p.V64I|PILRB_ENST00000444874.1_Intron|PILRB_ENST00000448382.1_Intron			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta	64	Ig-like V-type.			IVPN -> TAPD (in Ref. 2; CAC19193).	activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTTAGCCATAGTTCCCAACGT	0.532000													24	38					0	0	1	0	0
HERC2P3	0	broad.mit.edu	37	15	20588554	20588554	+	RNA	SNP	C	C	T	rs112526901	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:20588554C>T	ENST00000428453.1	-	0	4196																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CCGTGGAAAGCGGTTGCAGAA	0.473000													13	41					0	0	1	0	0
SCGB1A1	7356	broad.mit.edu	37	11	62189771	62189771	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62189771C>T	ENST00000534397.1	+	3	220	c.29C>T	c.(28-30)gCc>gTc	p.A10V	CTD-2531D15.4_ENST00000528983.1_RNA|SCGB1A1_ENST00000278282.2_Missense_Mutation_p.A45V			P11684	UTER_HUMAN	secretoglobin, family 1A, member 1 (uteroglobin)	45					embryo implantation|signal transduction	extracellular region	binding|phospholipase A2 inhibitor activity			lung(1)	1						TATGAGGCTGCCATGGAACTT	0.547000													12	28					0	0	1	0	0
PLA2G5	5322	broad.mit.edu	37	1	20412585	20412585	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:20412585C>T	ENST00000375108.3	+	3	318	c.50C>T	c.(49-51)gCt>gTt	p.A17V	PLA2G5_ENST00000486277.1_3'UTR	NM_000929.2	NP_000920.1	P39877	PA2G5_HUMAN	phospholipase A2, group V	17					lipid catabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity			NS(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000249)|Lung NSC(340;0.000287)|Breast(348;0.000812)|Ovarian(437;0.00328)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;8.15e-05)|Kidney(64;0.000184)|GBM - Glioblastoma multiforme(114;0.00089)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0652)		GGTGTGCCTGCTGTGCAAGGA	0.577000													9	15					0	0	1	0	0
PROSER1	80209	broad.mit.edu	37	13	39586877	39586877	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:39586877C>T	ENST00000352251.3	-	11	3345	c.2512G>A	c.(2512-2514)Gcc>Acc	p.A838T	PROSER1_ENST00000484434.2_Intron|PROSER1_ENST00000350125.3_Missense_Mutation_p.A816T	NM_025138.3	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	838																	AATGCTGAGGCGAATCCTGGG	0.527000													11	24					0	0	1	0	0
METTL15	196074	broad.mit.edu	37	11	28318407	28318407	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:28318407C>A	ENST00000342303.5	+	6	1162	c.707C>A	c.(706-708)gCt>gAt	p.A236D	METTL15_ENST00000406787.3_Silent_p.R221R|METTL15_ENST00000407364.3_Missense_Mutation_p.A236D|METTL15_ENST00000303459.6_Missense_Mutation_p.A236D	NM_152636.2	NP_689849.2	A6NJ78	MET15_HUMAN	methyltransferase like 15	236							methyltransferase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	14						AAGAAAATCGCTTCAGCAATT	0.488000													14	46					0.000219431	0.000224427	1	1	0
KIF21B	23046	broad.mit.edu	37	1	200961481	200961481	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:200961481G>A	ENST00000332129.2	-	16	2630	c.2314C>T	c.(2314-2316)Cgg>Tgg	p.R772W	KIF21B_ENST00000422435.2_Missense_Mutation_p.R772W|KIF21B_ENST00000461742.2_Missense_Mutation_p.R772W|KIF21B_ENST00000360529.5_Missense_Mutation_p.R772W	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	772					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						AGCCGCCGCCGCTGTTGCTCC	0.637000													29	39					0	0	1	0	0
PCDHAC2	0	broad.mit.edu	37	5	140348229	140348229	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140348229G>T	ENST00000289269.5	+	1	2410	c.1878G>T	c.(1876-1878)caG>caT	p.Q626H	PCDHA7_ENST00000525929.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		626	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTAGCCCAGACTTCTGACC	0.507000													15	18					6.72482e-11	7.20828e-11	1	1	0
BCL9L	283149	broad.mit.edu	37	11	118773618	118773618	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118773618C>A	ENST00000334801.3	-	6	1799		c.e6-1		BCL9L_ENST00000526143.1_Splice_Site	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like						negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CTTTAGGGGCCTGCAGAAGGA	0.677000													6	3					0.0293803	0.0295506	1	1	0
MAP3K19	80122	broad.mit.edu	37	2	135744355	135744355	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:135744355C>T	ENST00000375845.3	-	7	2117	c.2087G>A	c.(2086-2088)cGt>cAt	p.R696H	MAP3K19_ENST00000392915.1_Missense_Mutation_p.R713H|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000358371.4_Missense_Mutation_p.R583H|MAP3K19_ENST00000315513.3_5'UTR	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		ATTGGTGATACGTCTGCCTGA	0.408000													62	117					0	0	1	0	0
RAB37	326624	broad.mit.edu	37	17	72736966	72736966	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72736966C>T	ENST00000392610.1	+	2	194	c.153C>T	c.(151-153)gaC>gaT	p.D51D	RAB37_ENST00000340415.3_Intron|RAB37_ENST00000392614.4_Silent_p.D56D|RAB37_ENST00000392613.5_Silent_p.D51D|RAB37_ENST00000528438.1_Silent_p.D24D|RAB37_ENST00000392615.5_Intron|RAB37_ENST00000402449.4_Intron|RAB37_ENST00000392612.3_Intron			Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family	51					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	12						AATTCAAAGACGGGGCCTTCC	0.587000													54	76					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228135612	228135612	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:228135612G>A	ENST00000396578.3	+	25	1864	c.1702G>A	c.(1702-1704)Gat>Aat	p.D568N	AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	568	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AAAGGGCTTGGATGGAATTCC	0.507000													14	16					0	0	1	0	0
RAB11FIP3	9727	broad.mit.edu	37	16	521378	521378	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:521378G>A	ENST00000262305.4	+	3	1280	c.892G>A	c.(892-894)Gtc>Atc	p.V298I	RAB11FIP3_ENST00000457159.1_Missense_Mutation_p.V298I	NM_014700.3	NP_055515.1	O75154	RFIP3_HUMAN	RAB11 family interacting protein 3 (class II)	298					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			breast(1)|endometrium(2)|kidney(3)|lung(5)|upper_aerodigestive_tract(1)	12		Hepatocellular(16;0.0218)				CGATGACTTCGTCACCTATGA	0.597000													7	3					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139257950	139257950	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:139257950G>A	ENST00000406875.3	-	15	3414	c.3320C>T	c.(3319-3321)gCg>gTg	p.A1107V	HIPK2_ENST00000428878.2_Missense_Mutation_p.A1080V	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	1107	Autoinhibitory domain (AID).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					GGCCGCCGGCGCAGTGTAGGT	0.721000													22	16					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112969475	112969475	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:112969475C>T	ENST00000495514.1	+	4	875	c.171C>T	c.(169-171)tgC>tgT	p.C57C	BOC_ENST00000484034.1_Silent_p.C57C|BOC_ENST00000355385.3_Silent_p.C57C|BOC_ENST00000273395.4_Silent_p.C57C|BOC_ENST00000485230.1_Silent_p.C57C			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	57	Ig-like C2-type 1.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			TCTTGGGCTGCGTGGTGGAAC	0.597000													21	24					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74153283	74153283	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:74153283G>A	ENST00000443185.2	-	3	2045	c.1728C>T	c.(1726-1728)gcC>gcT	p.A576A	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	576					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		AGTCAGCAGCGGCACAGGCGG	0.706000													10	18					0	0	1	0	0
RGR	5995	broad.mit.edu	37	10	86017727	86017727	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:86017727G>A	ENST00000359452.4	+	6	759	c.721G>A	c.(721-723)Gca>Aca	p.A241T	RGR_ENST00000358110.5_Intron|RGR_ENST00000479725.1_3'UTR	NM_001012720.1|NM_002921.3	NP_001012738.1|NP_002912.2	P47804	RGR_HUMAN	retinal G protein coupled receptor	237			S -> F.		phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	17						CGCAGTCATCGCAGACGTGAC	0.512000													9	25					0	0	1	0	0
IVNS1ABP	10625	broad.mit.edu	37	1	185269591	185269591	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:185269591C>T	ENST00000367498.3	-	11	1842	c.1220G>A	c.(1219-1221)cGa>cAa	p.R407Q	IVNS1ABP_ENST00000459929.1_5'UTR|IVNS1ABP_ENST00000392007.3_Missense_Mutation_p.R189Q	NM_006469.4	NP_006460.2	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	407					interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(4)|prostate(2)	29						CATTTGAAATCGGGCTCTTGG	0.438000													30	65					0	0	1	0	0
CHCHD5	84269	broad.mit.edu	37	2	113343953	113343953	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:113343953C>A	ENST00000409719.1	+	3	373	c.320C>A	c.(319-321)gCt>gAt	p.A107D	CHCHD5_ENST00000324913.5_Intron			Q9BSY4	CHCH5_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 5	0										NS(1)|endometrium(1)|large_intestine(4)|urinary_tract(1)	7						GTAAGAGGGGCTCACCTCAGT	0.567000													12	12					0.00010058	0.000103117	1	1	0
QTRT1	81890	broad.mit.edu	37	19	10823503	10823503	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10823503G>A	ENST00000250237.5	+	8	941	c.931G>A	c.(931-933)Ggc>Agc	p.G311S		NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	311					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			GAAGGACTTCGGCCCCATAGA	0.647000													47	60					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43221187	43221187	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:43221187C>A	ENST00000255226.6	+	8	1821	c.1005C>A	c.(1003-1005)gcC>gcA	p.A335A	SLC14A2_ENST00000586448.1_Silent_p.A335A	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	335						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TGTCAGTGGCCACACCCTTCG	0.577000													15	22					8.60227e-14	9.36079e-14	1	1	0
PRSS21	10942	broad.mit.edu	37	16	2870994	2870994	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2870994G>A	ENST00000455114.1	+	5	689	c.583G>A	c.(583-585)Gcc>Acc	p.A195T	PRSS21_ENST00000005995.3_Missense_Mutation_p.A197T|PRSS21_ENST00000450020.3_Missense_Mutation_p.A197T|PRSS21_ENST00000575739.1_Intron	NM_001270452.1|NM_006799.3|NM_144956.2	NP_001257381.1|NP_006790.1|NP_659205.1	Q9Y6M0	TEST_HUMAN	protease, serine, 21 (testisin)	197	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	15						AGTTCAGGTCGCCATCATAAA	0.547000													67	119					0	0	1	0	0
MET	0	broad.mit.edu	37	7	116395427	116395427	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:116395427C>T	ENST00000397752.3	+	6	1920	c.1720C>T	c.(1720-1722)Ccc>Tcc	p.P574S	MET_ENST00000495962.1_3'UTR|MET_ENST00000318493.6_Missense_Mutation_p.P574S|MET_ENST00000436117.2_Missense_Mutation_p.P574S	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	574	IPT/TIG 1.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AAATAGTGCACCCCTTGAAGG	0.343000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				34	37					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12139743	12139743	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:12139743G>A	ENST00000263035.4	+	8	1481	c.1419G>A	c.(1417-1419)acG>acA	p.T473T	DHTKD1_ENST00000465617.1_3'UTR	NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	473					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			GACTCATGACGCAGGAGGAGG	0.488000													22	32					0	0	1	0	0
MAU2	23383	broad.mit.edu	37	19	19454733	19454733	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19454733C>T	ENST00000392313.5	+	10	1107	c.1061C>T	c.(1060-1062)gCc>gTc	p.A354V	MAU2_ENST00000585823.2_3'UTR|MAU2_ENST00000262815.8_Missense_Mutation_p.A354V	NM_015329.3	NP_056144.3	Q9Y6X3	SCC4_HUMAN	MAU2 sister chromatid cohesion factor	354					cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	18						GGTCACAAGGCCACGGCGCTG	0.587000													12	44					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47472244	47472244	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:47472244G>A	ENST00000266581.4	-	2	1008	c.542C>T	c.(541-543)cCg>cTg	p.P181L	AMIGO2_ENST00000321382.3_Missense_Mutation_p.P181L|AMIGO2_ENST00000550413.1_Missense_Mutation_p.P181L|AMIGO2_ENST00000429635.1_Missense_Mutation_p.P181L	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	181					heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					CAAATCCATCGGAAACTGTGT	0.398000													5	56					0	0	1	0	0
TMEM61	199964	broad.mit.edu	37	1	55451849	55451849	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55451849C>T	ENST00000371268.3	+	2	369	c.95C>T	c.(94-96)aCg>aTg	p.T32M	RP11-12C17.2_ENST00000436960.1_RNA	NM_182532.1	NP_872338.1	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	32						integral to membrane				endometrium(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	4						GTGGCCGGGACGCTCTGCTTC	0.662000													17	24					0	0	1	0	0
PIGK	10026	broad.mit.edu	37	1	77620137	77620137	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:77620137C>T	ENST00000370812.3	-	9	1006	c.983G>A	c.(982-984)aGc>aAc	p.S328N	PIGK_ENST00000370813.5_Missense_Mutation_p.S252N|PIGK_ENST00000445065.1_Missense_Mutation_p.S234N|PIGK_ENST00000359130.1_Missense_Mutation_p.S328N	NM_005482.2	NP_005473.1	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class K	328					attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	19						TGAATACCTGCTTTCCATGAT	0.313000													4	20					0	0	1	0	0
RC3H2	54542	broad.mit.edu	37	9	125621135	125621135	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:125621135C>T	ENST00000373670.1	-	11	2696	c.2096G>A	c.(2095-2097)cGc>cAc	p.R699H	RC3H2_ENST00000357244.2_Missense_Mutation_p.R699H|RC3H2_ENST00000423239.2_Missense_Mutation_p.R699H			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	699	Pro-rich.					cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GCGCCAGATGCGCCTGCTGTC	0.488000													29	49					0	0	1	0	0
KIAA1468	57614	broad.mit.edu	37	18	59898499	59898499	+	Silent	SNP	C	C	T	rs147870131		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:59898499C>T	ENST00000256858.6	+	9	1769	c.1521C>T	c.(1519-1521)taC>taT	p.Y507Y	KIAA1468_ENST00000592479.1_3'UTR|KIAA1468_ENST00000398130.2_Silent_p.Y507Y			Q9P260	K1468_HUMAN	KIAA1468	507							binding			autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				GTTTAGGATACGAGGTAAATT	0.338000													6	64					0	0	1	0	0
PTGER4	5734	broad.mit.edu	37	5	40681890	40681890	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:40681890C>T	ENST00000302472.3	+	2	1819	c.795C>T	c.(793-795)ggC>ggT	p.G265G		NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	265					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						GCATCGCGGGCGCCGAGATCC	0.706000													6	36					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120464896	120464896	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:120464896G>A	ENST00000256646.2	-	28	5395	c.5176C>T	c.(5176-5178)Cgt>Tgt	p.R1726C		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1726					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity	p.R1726C(1)		breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGCTCACGACGCTTGTGATTG	0.488000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				7	48					0	0	1	0	0
LPHN1	22859	broad.mit.edu	37	19	14267883	14267883	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:14267883G>A	ENST00000340736.6	-	16	3132	c.2835C>T	c.(2833-2835)ggC>ggT	p.G945G	CTB-55O6.12_ENST00000592086.1_RNA|LPHN1_ENST00000361434.3_Silent_p.G940G|CTB-55O6.12_ENST00000588387.1_RNA	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	945					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AGAGGTGCACGCCCTCCAGGC	0.617000													5	10					0	0	1	0	0
XYLT2	64132	broad.mit.edu	37	17	48431803	48431803	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48431803C>T	ENST00000017003.2	+	3	712	c.663C>T	c.(661-663)agC>agT	p.S221S	XYLT2_ENST00000507602.1_Silent_p.S221S	NM_022167.2	NP_071450.2	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	221					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(2)|urinary_tract(1)	12	Breast(11;7.18e-19)					GGGATGAGAGCCAAGCCCAGC	0.662000													4	11					0	0	1	0	0
ORAI2	80228	broad.mit.edu	37	7	102087259	102087259	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:102087259C>T	ENST00000356387.2	+	4	760	c.525C>T	c.(523-525)ccC>ccT	p.P175P	ORAI2_ENST00000478730.1_Silent_p.P175P|ORAI2_ENST00000403646.3_Silent_p.P175P|ORAI2_ENST00000473939.1_Silent_p.P175P|ORAI2_ENST00000488996.1_3'UTR	NM_001126340.1|NM_001271818.1|NM_001271819.1|NM_032831.3	NP_001119812.1|NP_001258747.1|NP_001258748.1|NP_116220.1	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator 2	175						integral to membrane	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15						AGTTCCTCCCCGTGGATGCCC	0.682000													12	59					0	0	1	0	0
RUFY1	80230	broad.mit.edu	37	5	179034611	179034611	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:179034611C>T	ENST00000319449.4	+	17	1946	c.1934C>T	c.(1933-1935)gCg>gTg	p.A645V	RUFY1_ENST00000508797.1_3'UTR|RUFY1_ENST00000437570.2_Missense_Mutation_p.A537V|RUFY1_ENST00000393438.2_Missense_Mutation_p.A537V|RUFY1_ENST00000377001.2_3'UTR	NM_025158.4	NP_079434.3	Q96T51	RUFY1_HUMAN	RUN and FYVE domain containing 1	645					endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATGACGAAGCGACACACTGT	0.572000										HNSCC(44;0.11)			5	49					0	0	1	0	0
PIH1D1	55011	broad.mit.edu	37	19	49950633	49950633	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49950633C>A	ENST00000262265.5	-	6	808	c.573G>T	c.(571-573)ggG>ggT	p.G191G	PIH1D1_ENST00000596049.1_Silent_p.G191G	NM_017916.2	NP_060386.1	Q9NWS0	PIHD1_HUMAN	PIH1 domain containing 1	191					box C/D snoRNP assembly	pre-snoRNP complex				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|urinary_tract(1)	11		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		TGTACAGGTCCCCCAGCTCCT	0.627000													8	56					0.000274275	0.000279654	1	1	0
ERICH1	157697	broad.mit.edu	37	8	642503	642503	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:642503G>A	ENST00000262109.7	-	3	356	c.279C>T	c.(277-279)aaC>aaT	p.N93N	ERICH1_ENST00000518277.1_5'UTR|ERICH1_ENST00000522706.1_Intron	NM_207332.1	NP_997215.1	Q86X53	ERIC1_HUMAN	glutamate-rich 1	93										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)	20		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		CGCTGGAGGCGTTCTCGGGGC	0.582000													20	37					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74407619	74407619	+	Missense_Mutation	SNP	C	C	T	rs149731074		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:74407619C>T	ENST00000376332.3	-	11	1721	c.1225G>A	c.(1225-1227)Gtc>Atc	p.V409I	CHRDL2_ENST00000263671.5_Missense_Mutation_p.R427H	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	409					cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					GCTAGGAAGACGTTCCAGTGA	0.537000													13	20					0	0	1	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43693986	43693986	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43693986C>T	ENST00000564079.1	+	15	1909	c.1669C>T	c.(1669-1671)Cga>Tga	p.R557*	TUBGCP4_ENST00000399460.3_3'UTR|TUBGCP4_ENST00000260383.7_Nonsense_Mutation_p.R558*	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	558					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		TGAAAGCATCCGATTGGCTCA	0.423000													40	54					0	0	1	0	0
KIAA0753	9851	broad.mit.edu	37	17	6531530	6531530	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:6531530T>G	ENST00000361413.3	-	3	983	c.625A>C	c.(625-627)Aac>Cac	p.N209H	KIAA0753_ENST00000572370.1_5'UTR|KIAA0753_ENST00000542606.1_5'UTR	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	209						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		TCACTTATGTTTTTGTGGTCA	0.458000													18	46					0	0	1	0	0
ZNF816	125893	broad.mit.edu	37	19	53453281	53453281	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53453281G>A	ENST00000357666.4	-	5	2047	c.1747C>T	c.(1747-1749)Cat>Tat	p.H583Y	ZNF816_ENST00000434371.2_Intron|ZNF816_ENST00000444460.2_Missense_Mutation_p.H583Y|ZNF321P_ENST00000391777.3_Intron	NM_001031665.2	NP_001026835.1	Q0VGE8	ZN816_HUMAN	zinc finger protein 816	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(10)|lung(9)|stomach(1)|urinary_tract(2)	27						ACTCTCTGATGTTGTGCAAGG	0.373000													34	46					0	0	1	0	0
FAM222B	55731	broad.mit.edu	37	17	27086248	27086248	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27086248G>A	ENST00000341217.5	-	3	944	c.729C>T	c.(727-729)acC>acT	p.T243T	FAM222B_ENST00000582266.1_3'UTR|FAM222B_ENST00000581407.1_Silent_p.T243T|FAM222B_ENST00000452648.3_Silent_p.T243T	NM_018182.2	NP_060652.2	Q8WU58	CQ063_HUMAN	family with sequence similarity 222, member B	243																	AGGTAGACACGGTCACATTCG	0.607000													3	9					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92459273	92459273	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:92459273C>T	ENST00000318445.6	+	2	445	c.231C>T	c.(229-231)gaC>gaT	p.D77D	SLCO3A1_ENST00000424469.2_Silent_p.D77D	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	77					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			AGAGCGCTGACGTGGGTGTGA	0.627000													27	52					0	0	1	0	0
FZD6	8323	broad.mit.edu	37	8	104336880	104336880	+	Silent	SNP	G	G	A	rs138437813	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:104336880G>A	ENST00000358755.4	+	4	863	c.546G>A	c.(544-546)gcG>gcA	p.A182A	FZD6_ENST00000540287.1_Intron|FZD6_ENST00000523739.1_Silent_p.A150A|FZD6_ENST00000522566.1_Silent_p.A182A	NM_001164616.1|NM_003506.3	NP_001158088.1|NP_003497.2	O60353	FZD6_HUMAN	frizzled family receptor 6	182					angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			ACCAGTGTGCGCCTCCATGCC	0.393000													5	61					0	0	1	0	0
ASPSCR1	79058	broad.mit.edu	37	17	79941442	79941442	+	Silent	SNP	C	C	T	rs145252391	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79941442C>T	ENST00000306729.7	+	3	268	c.171C>T	c.(169-171)agC>agT	p.S57S	ASPSCR1_ENST00000306739.4_Silent_p.S57S|ASPSCR1_ENST00000581647.1_Silent_p.S57S|ASPSCR1_ENST00000580534.1_5'UTR	NM_001251888.1	NP_001238817.1	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region, candidate 1	57							protein binding		ASPSCR1/TFE3(167)	breast(2)|large_intestine(2)	4	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			TTCAGAGGAGCGTGCTCGACC	0.622000			T	TFE3	alveolar soft part sarcoma								7	14					0	0	1	0	0
KRT28	162605	broad.mit.edu	37	17	38950185	38950185	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38950185G>A	ENST00000306658.7	-	6	1157	c.1092C>T	c.(1090-1092)acC>acT	p.T364T		NM_181535.3	NP_853513.2	Q7Z3Y7	K1C28_HUMAN	keratin 28	364	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30		Breast(137;0.000301)				CCTCGGTCTCGGTTCTGACCT	0.562000													9	139					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41795087	41795087	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:41795087C>A	ENST00000396930.3	-	17	3583		c.e17-1		KAT6A_ENST00000265713.2_Splice_Site|KAT6A_ENST00000406337.1_Splice_Site	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A						histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										GAAATGGTTTCTGTTTAATAG	0.343000													17	29					3.51602e-12	3.7986e-12	1	1	0
FBXO32	114907	broad.mit.edu	37	8	124547022	124547022	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:124547022T>G	ENST00000517956.1	-	2	340	c.149A>C	c.(148-150)aAt>aCt	p.N50T	FBXO32_ENST00000443022.2_Missense_Mutation_p.N50T	NM_058229.3|NM_148177.2	NP_478136.1|NP_680482.1	Q969P5	FBX32_HUMAN	F-box protein 32	50										autonomic_ganglia(1)|breast(3)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)|stomach(1)	21	Lung NSC(37;1.13e-13)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GTTGAAAAGATTCTCCTTATT	0.378000													29	38					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79434602	79434602	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:79434602C>A	ENST00000264895.6	+	65	10510	c.10070C>A	c.(10069-10071)aCc>aAc	p.T3357N		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3352					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CTTATCTCCACCATGCCGTTG	0.468000													7	78					5.18039e-06	5.37127e-06	1	1	0
NAV2	89797	broad.mit.edu	37	11	19901631	19901631	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:19901631C>T	ENST00000396085.1	+	5	1089	c.728C>T	c.(727-729)gCg>gTg	p.A243V	NAV2_ENST00000534229.1_3'UTR|NAV2_ENST00000540292.1_Missense_Mutation_p.A174V|NAV2_ENST00000349880.4_Missense_Mutation_p.A243V|NAV2_ENST00000396087.3_Missense_Mutation_p.A243V|NAV2_ENST00000360655.4_Missense_Mutation_p.A179V|NAV2_ENST00000527559.2_Missense_Mutation_p.A172V	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	243	Gln-rich.					nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						CACCAGCCAGCGCCACATCAG	0.632000													6	7					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6305756	6305756	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:6305756C>T	ENST00000264870.3	-	3	412	c.147G>A	c.(145-147)acG>acA	p.T49T		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	49					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GGTGAACGCTCGTGACATTAA	0.383000													20	34					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61802186	61802186	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:61802186T>C	ENST00000325324.6	+	19	1951		c.e19+2		IPO11_ENST00000409296.3_Splice_Site|KIF2A_ENST00000509663.2_Intron	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11							cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		AACATGCAGGTAATTATATTG	0.328000													37	27					0	0	1	0	0
DHX8	1659	broad.mit.edu	37	17	41598905	41598905	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41598905C>T	ENST00000262415.3	+	21	3307	c.3235C>T	c.(3235-3237)Cgc>Tgc	p.R1079C	DHX8_ENST00000540306.1_Missense_Mutation_p.R1079C	NM_004941.1	NP_004932.1	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	1079						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		CCAGGACATTCGCAAGCAGAT	0.483000													23	46					0	0	1	0	0
AVPR1A	0	broad.mit.edu	37	12	63544055	63544055	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:63544055C>T	ENST00000299178.2	-	1	667	c.562G>A	c.(562-564)Gtc>Atc	p.V188I		NM_000706.4	NP_000697.1	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	188					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|prostate(2)|skin(1)	26			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	ATGGAGAAGACGAAGTACTGC	0.642000													7	69					0	0	1	0	0
PCDHA13	0	broad.mit.edu	37	5	140263357	140263357	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140263357C>T	ENST00000289272.2	+	1	1504	c.1504C>T	c.(1504-1506)Cgt>Tgt	p.R502C	PCDHA7_ENST00000525929.1_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.R502C|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGGCGAGCGTGCGCTGTC	0.672000													34	37					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53185103	53185103	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53185103C>T	ENST00000417996.2	-	7	1496	c.1422G>A	c.(1420-1422)gcG>gcA	p.A474A	KRT3_ENST00000309505.3_Silent_p.A474A	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	474	Coil 2.|Rod.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						GGTCATCCTTCGCCTGCTGTA	0.617000													42	76					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44610888	44610888	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44610888G>A	ENST00000336976.6	+	6	829	c.575G>A	c.(574-576)cGt>cAt	p.R192H	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	192					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				TCAGCCCTTCGTATTCATCAG	0.418000													73	91					0	0	1	0	0
ATHL1	80162	broad.mit.edu	37	11	294384	294384	+	Silent	SNP	C	C	T	rs141863244		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:294384C>T	ENST00000409548.2	+	13	2041	c.1926C>T	c.(1924-1926)tcC>tcT	p.S642S	ATHL1_ENST00000409655.1_Silent_p.S394S|ATHL1_ENST00000409479.1_Silent_p.S669S	NM_025092.4	NP_079368.3	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1 (yeast)	642					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|skin(3)	17		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCGAGGACTCCGTGACCGTGG	0.602000													7	70					0	0	1	0	0
NMI	9111	broad.mit.edu	37	2	152132079	152132079	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:152132079G>A	ENST00000243346.5	-	6	1023	c.553C>T	c.(553-555)Cga>Tga	p.R185*		NM_004688.2	NP_004679.2	Q13287	NMI_HUMAN	N-myc (and STAT) interactor	185					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				BRCA - Breast invasive adenocarcinoma(221;0.0571)		CCTCCATTTCGGGACTTTGAA	0.453000													25	26					0	0	1	0	0
APMAP	57136	broad.mit.edu	37	20	24959425	24959425	+	Silent	SNP	C	C	T	rs144418356		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:24959425C>T	ENST00000217456.2	-	3	596	c.306G>A	c.(304-306)ccG>ccA	p.P102P	APMAP_ENST00000447138.1_Silent_p.P102P	NM_020531.2	NP_065392.1			adipocyte plasma membrane associated protein																		CTATGGACTCCGGTCCAACAA	0.542000													24	47					0	0	1	0	0
MAP7D1	55700	broad.mit.edu	37	1	36639029	36639029	+	Missense_Mutation	SNP	G	G	A	rs148371637		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:36639029G>A	ENST00000316156.4	+	5	1142	c.689G>A	c.(688-690)cGc>cAc	p.R230H	MAP7D1_ENST00000373150.4_Missense_Mutation_p.R230H|MAP7D1_ENST00000474796.1_3'UTR|MAP7D1_ENST00000373151.2_Missense_Mutation_p.R230H			Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	230						cytoplasm|spindle				breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	19		Myeloproliferative disorder(586;0.0393)				CGGCAGCAGCGCTGGTCCTGG	0.627000													33	50					0	0	1	0	0
TCTE1	202500	broad.mit.edu	37	6	44250230	44250230	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:44250230C>T	ENST00000371505.4	-	4	1035	c.913G>A	c.(913-915)Gac>Aac	p.D305N	TMEM151B_ENST00000438774.2_Intron|TCTE1_ENST00000371504.1_Intron|TCTE1_ENST00000371503.3_Intron	NM_182539.3	NP_872345.2	Q5JU00	TCTE1_HUMAN	t-complex-associated-testis-expressed 1	305										breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACTGGGTGGTCCAGAAGGCTT	0.572000													7	51					0	0	1	0	0
CORO7	79585	broad.mit.edu	37	16	4407211	4407211	+	Silent	SNP	C	C	T	rs148065861		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4407211C>T	ENST00000251166.4	-	26	2788	c.2643G>A	c.(2641-2643)gcG>gcA	p.A881A	CORO7_ENST00000574025.1_Silent_p.A796A|CORO7_ENST00000539968.1_Silent_p.A661A|CORO7_ENST00000537233.2_Silent_p.A863A|CORO7-PAM16_ENST00000572467.1_Silent_p.A881A|CORO7-PAM16_ENST00000572274.1_5'UTR	NM_024535.4	NP_078811.3			coronin 7											breast(3)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|prostate(2)|skin(2)|urinary_tract(2)	23						CCAGGTACTGCGCTGAGGATG	0.612000													9	21					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39050311	39050311	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:39050311G>A	ENST00000295373.6	-	17	3241	c.3115C>T	c.(3115-3117)Cga>Tga	p.R1039*		NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1039							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TCTCGTAATCGTATTTTTGAG	0.423000													16	30					0	0	1	0	0
CALCA	796	broad.mit.edu	37	11	14989365	14989365	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:14989365G>A	ENST00000361010.3	-	4	337	c.263C>T	c.(262-264)aCc>aTc	p.T88I	CALCA_ENST00000486207.1_Missense_Mutation_p.T88I|CALCB_ENST00000523376.1_Intron	NM_001033953.2	NP_001029125.1	P06881	CALCA_HUMAN	calcitonin-related polypeptide alpha	88					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	8					Phentolamine(DB00692)	AGTCACACAGGTGGCAGTGTC	0.542000													3	47					0	0	1	0	0
TCF7	6932	broad.mit.edu	37	5	133451600	133451600	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:133451600G>A	ENST00000395029.1	+	3	512	c.316_splice	c.e3-1	p.G106_splice	TCF7_ENST00000342854.5_Splice_Site_p.G106_splice|TCF7_ENST00000518915.1_5'UTR|TCF7_ENST00000321584.4_Splice_Site_p.G106_splice|TCF7_ENST00000378560.4_5'UTR|TCF7_ENST00000378564.1_Splice_Site_p.G106_splice|TCF7_ENST00000520958.1_5'UTR|TCF7_ENST00000432532.2_5'UTR|TCF7_ENST00000321603.6_Splice_Site_p.G106_splice|TCF7_ENST00000395023.1_5'UTR			P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific, HMG-box)	106					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding			kidney(2)|large_intestine(7)|lung(2)|skin(1)	12		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTTTTTCCAGGCCTGAAGGCC	0.597000													14	22					0	0	1	0	0
RASD1	51655	broad.mit.edu	37	17	17398529	17398529	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:17398529C>T	ENST00000225688.3	-	2	967	c.756G>A	c.(754-756)cgG>cgA	p.R252R	RASD1_ENST00000579152.1_3'UTR	NM_001199989.1|NM_016084.4	NP_001186918.1|NP_057168.1	Q9Y272	RASD1_HUMAN	RAS, dexamethasone-induced 1	252					G-protein coupled receptor protein signaling pathway|small GTPase mediated signal transduction	nucleus|perinuclear region of cytoplasm|plasma membrane	GTP binding|GTPase activity			endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	4						GTACGCTGGGCCGGCGCGCGA	0.716000													7	12					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202626434	202626434	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:202626434T>C	ENST00000264276.6	-	4	655	c.283A>G	c.(283-285)Act>Gct	p.T95A	ALS2_ENST00000496244.1_5'UTR|ALS2_ENST00000467448.1_Missense_Mutation_p.T95A	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	95					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						GTTGCCACAGTAATAACATAT	0.507000													39	65					0	0	1	0	0
KIF11	3832	broad.mit.edu	37	10	94368802	94368802	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:94368802G>A	ENST00000260731.3	+	5	503	c.413G>A	c.(412-414)cGt>cAt	p.R138H		NM_004523.3	NP_004514.2	P52732	KIF11_HUMAN	kinesin family member 11	138	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ATAATTCCACGTACCCTTCAT	0.348000													26	37					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	157000543	157000543	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:157000543G>T	ENST00000348165.5	+	13	2083	c.1723G>T	c.(1723-1725)Gca>Tca	p.A575S		NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	575					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		ATATATTACAGCATTTCAGAG	0.393000													19	28					1.96292e-10	2.09789e-10	1	1	0
ITGAD	3681	broad.mit.edu	37	16	31422650	31422650	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31422650G>A	ENST00000389202.2	+	14	1568	c.1519G>A	c.(1519-1521)Gct>Act	p.A507T		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	507					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GCAGTGTGACGCTGTTCTCCG	0.622000													48	72					0	0	1	0	0
MIR323A	0	broad.mit.edu	37	14	101492098	101492098	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:101492098G>A	ENST00000362199.1	+	0	30					NR_029890.1																						GGTCCGTGGCGCGTTCGCTTT	0.537000													22	84					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74446757	74446757	+	Missense_Mutation	SNP	C	C	T	rs139377062	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:74446757C>T	ENST00000339953.5	-	6	819	c.698G>A	c.(697-699)cGc>cAc	p.R233H		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	233	EGF-like.					extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GCAGCTCATGCGACAAGGATT	0.627000													13	120					0	0	1	0	0
ALDH7A1	501	broad.mit.edu	37	5	125890047	125890047	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:125890047C>A	ENST00000409134.3	-	13	1351	c.1132G>T	c.(1132-1134)Gtg>Ttg	p.V378L	ALDH7A1_ENST00000553117.1_Intron|ALDH7A1_ENST00000447989.2_Intron	NM_001182.4|NM_001201377.1	NP_001173.2|NP_001188306.1	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	378					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			endometrium(1)|kidney(4)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	AACATGCTCACTGCCTGCTTG	0.473000													6	147					0.248553	0.248844	1	1	0
APBA1	320	broad.mit.edu	37	9	72131762	72131762	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:72131762T>C	ENST00000265381.4	-	2	587	c.365A>G	c.(364-366)tAc>tGc	p.Y122C		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	122					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						CTCGGGCCGGTACTGCACAGC	0.731000													4	9					0	0	1	0	0
DALRD3	55152	broad.mit.edu	37	3	49053301	49053301	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49053301C>T	ENST00000440857.1	-	11	1749	c.1047G>A	c.(1045-1047)atG>atA	p.M349I	WDR6_ENST00000395474.3_3'UTR|DALRD3_ENST00000395462.4_Missense_Mutation_p.C316Y|DALRD3_ENST00000441576.2_Missense_Mutation_p.M474I|DALRD3_ENST00000341949.4_Missense_Mutation_p.C483Y|DALRD3_ENST00000313778.5_Missense_Mutation_p.C316Y			Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	54					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding			breast(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CAGGAACTTGCATATCTAGAG	0.517000													25	41					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54554980	54554980	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:54554980C>A	ENST00000566473.2	+	15	1914	c.1914C>A	c.(1912-1914)tgC>tgA	p.C638*	ANKFN1_ENST00000318698.2_Nonsense_Mutation_p.C638*			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	638										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						ACATTCTCTGCCACGTGAAGA	0.408000													9	85					0.000978159	0.000994766	1	1	0
DSCAM	1826	broad.mit.edu	37	21	41710040	41710040	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:41710040C>T	ENST00000400454.1	-	8	2248	c.1771G>A	c.(1771-1773)Gtg>Atg	p.V591M		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	591	Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTCACGGTCACGTGGACGCTC	0.502000													31	13					0	0	1	0	0
TMEM39B	55116	broad.mit.edu	37	1	32557293	32557293	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32557293C>T	ENST00000427288.1	+	7	743	c.263C>T	c.(262-264)cCg>cTg	p.P88L	TMEM39B_ENST00000336294.5_Missense_Mutation_p.P203L|TMEM39B_ENST00000456834.2_Silent_p.S151S|TMEM39B_ENST00000373634.4_Missense_Mutation_p.P4L|TMEM39B_ENST00000487305.1_3'UTR			Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	203						integral to membrane				endometrium(2)|kidney(1)|lung(5)|ovary(1)|prostate(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				ATGTACATTCCGTTCCTGCAG	0.612000													15	22					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100623347	100623347	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:100623347C>T	ENST00000317233.4	-	6	855	c.620G>A	c.(619-621)aGc>aAc	p.S207N	AFF3_ENST00000409579.1_Missense_Mutation_p.S232N|AFF3_ENST00000356421.2_Missense_Mutation_p.S232N|AFF3_ENST00000409236.1_Missense_Mutation_p.S207N	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	207					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TCCGCTGCTGCTGTGCTTGGC	0.597000													20	29					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47571860	47571860	+	Silent	SNP	C	C	T	rs142306823		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47571860C>T	ENST00000334194.3	+	9	1131	c.1128C>T	c.(1126-1128)taC>taT	p.Y376Y	CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	376						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						TCCGCCTCTACGCACCGGTAG	0.473000													29	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179400468	179400468	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179400468G>T	ENST00000589042.1	-	358	101098	c.100874C>A	c.(100873-100875)cCt>cAt	p.P33625H	TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P24752H|TTN_ENST00000591111.1_Missense_Mutation_p.P31984H|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P24560H|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P31057H|TTN_ENST00000359218.5_Missense_Mutation_p.P24685H|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000588804.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31984							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGATCACAGGATCTGGTTT	0.448000													25	41					5.49717e-05	5.64882e-05	1	1	0
WT1	7490	broad.mit.edu	37	11	32413578	32413578	+	Nonsense_Mutation	SNP	G	G	A	rs121907909		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:32413578G>A	ENST00000332351.3	-	9	1656	c.1372C>T	c.(1372-1374)Cga>Tga	p.R458*	WT1_ENST00000448076.3_Nonsense_Mutation_p.R458*|WT1_ENST00000379079.2_Nonsense_Mutation_p.R246*|WT1_ENST00000530998.1_Nonsense_Mutation_p.R229*	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1	390					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.R390*(9)|p.V380_S410del(1)	EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GAGAACTTTCGCTGACAAGTT	0.458000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				78	79					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8660982	8660982	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8660982G>A	ENST00000270328.4	-	10	1578	c.1312C>T	c.(1312-1314)Cgt>Tgt	p.R438C	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.R438C			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	438	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						ATGTAGTCACGGCTGCAGGAT	0.582000													33	43					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41029390	41029390	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:41029390G>A	ENST00000324545.7	+	19	3412	c.2779G>A	c.(2779-2781)Gta>Ata	p.V927I	USP9X_ENST00000378308.2_Missense_Mutation_p.V927I	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	927					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TAAAGCCAACGTAGCCCATAC	0.398000													35	4					0	0	1	0	0
OVOL1	5017	broad.mit.edu	37	11	65562113	65562113	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65562113C>T	ENST00000335987.3	+	3	775	c.423C>T	c.(421-423)aaC>aaT	p.N141N	OVOL1_ENST00000532448.1_Silent_p.N79N	NM_004561.3	NP_004552.2	O14753	OVOL1_HUMAN	ovo-like zinc finger 1	141					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	6				READ - Rectum adenocarcinoma(159;0.17)		AGTGTCACAACGACGTCAAGA	0.577000													13	26					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8993026	8993026	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8993026G>T	ENST00000397910.4	-	67	41936	c.41733C>A	c.(41731-41733)agC>agA	p.S13911R	MUC16_ENST00000380951.5_Missense_Mutation_p.S552R	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13914				Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGGTACAGAGCTCCGATGGG	0.537000													21	40					2.70639e-06	2.81266e-06	1	1	0
ONECUT1	3175	broad.mit.edu	37	15	53081569	53081569	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:53081569G>A	ENST00000305901.5	-	1	640	c.513C>T	c.(511-513)gaC>gaT	p.D171D	ONECUT1_ENST00000561401.2_Intron	NM_004498.2	NP_004489.1	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	171					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	17				all cancers(107;0.0708)		TGCCGGCCACGTCCTTGTGGT	0.667000													4	54					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26964904	26964904	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26964904A>G	ENST00000528896.2	-	14	1795	c.1721T>C	c.(1720-1722)gTg>gCg	p.V574A	KIAA0100_ENST00000544884.1_Missense_Mutation_p.V431A|KIAA0100_ENST00000389003.3_Missense_Mutation_p.V431A	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	574						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CTTCAAGTCCACCTTCCACAG	0.473000													16	31					0	0	1	0	0
MLH1	4292	broad.mit.edu	37	3	37090489	37090489	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:37090489C>T	ENST00000231790.2	+	18	2300	c.2084C>T	c.(2083-2085)tCg>tTg	p.S695L	MLH1_ENST00000435176.1_Missense_Mutation_p.S597L|MLH1_ENST00000536378.1_Missense_Mutation_p.454_454insL|MLH1_ENST00000455445.2_Missense_Mutation_p.S454L|MLH1_ENST00000539477.1_Missense_Mutation_p.S454L|MLH1_ENST00000458205.2_Missense_Mutation_p.S454L	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	695					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						TCTGAGGAGTCGACCCTCTCA	0.488000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				10	16					0	0	1	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113208477	113208477	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113208477A>G	ENST00000261965.3	-	8	1046	c.860T>C	c.(859-861)tTg>tCg	p.L287S	TUBGCP3_ENST00000375669.3_Missense_Mutation_p.L287S	NM_006322.4	NP_006313.1	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	287					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					TGTGTCTCTCAAAGACCTACT	0.388000													24	23					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106729832	106729832	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:106729832G>A	ENST00000299045.3	+	8	1157	c.983G>A	c.(982-984)cGt>cAt	p.R328H		NM_152772.1	NP_689985.1	Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	328										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						GATGGAGCACGTCTTCAGGAA	0.368000													5	35					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47404230	47404230	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:47404230T>C	ENST00000285039.7	-	25	3598	c.3299A>G	c.(3298-3300)aAc>aGc	p.N1100S	MYO5B_ENST00000324581.6_Missense_Mutation_p.N241S	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1100					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GTTTGATGGGTTCCGCCTATG	0.483000													44	78					0	0	1	0	0
CCR7	1236	broad.mit.edu	37	17	38711171	38711171	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38711171G>A	ENST00000246657.2	-	3	1022	c.960C>T	c.(958-960)tgC>tgT	p.C320C	CCR7_ENST00000579344.1_Silent_p.C314C	NM_001838.3	NP_001829.1	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7	320					cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		Breast(137;0.000496)				AAGGGTTGACGCAGCAGCGGA	0.582000													14	13					0	0	1	0	0
PEX1	5189	broad.mit.edu	37	7	92134102	92134102	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:92134102G>T	ENST00000248633.4	-	12	2110	c.2015C>A	c.(2014-2016)gCt>gAt	p.A672D	PEX1_ENST00000428214.1_Intron|PEX1_ENST00000541751.1_Missense_Mutation_p.A89D|PEX1_ENST00000438045.1_Missense_Mutation_p.A350D	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	672			Missing (in NALD).		microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TTCCGGGACAGCAGGCAGTCC	0.522000													28	48					2.48779e-11	2.67617e-11	1	1	0
IL31RA	133396	broad.mit.edu	37	5	55195937	55195937	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:55195937G>T	ENST00000396834.1	+	10	1485	c.989G>T	c.(988-990)aGg>aTg	p.R330M	IL31RA_ENST00000396836.2_Missense_Mutation_p.R349M|IL31RA_ENST00000354961.4_Missense_Mutation_p.R330M|IL31RA_ENST00000359040.5_Missense_Mutation_p.R349M|IL31RA_ENST00000297015.3_Missense_Mutation_p.R207M|IL31RA_ENST00000490985.1_Missense_Mutation_p.R207M|IL31RA_ENST00000447346.2_Missense_Mutation_p.R349M	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	317	Fibronectin type-III 4.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				GCCACCCTGAGGATTCCAGCT	0.478000													33	56					6.53348e-20	7.23485e-20	1	1	0
GPRASP1	9737	broad.mit.edu	37	X	101912705	101912705	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:101912705C>T	ENST00000537097.1	+	6	4677	c.3864C>T	c.(3862-3864)ggC>ggT	p.G1288G	GPRASP1_ENST00000444152.1_Silent_p.G1288G|GPRASP1_ENST00000415986.1_Silent_p.G1288G|RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000361600.5_Silent_p.G1288G	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	1288	OPRD1-binding.					cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TAGCTACAGGCAATGCCAAAA	0.373000													19	20					0	0	1	0	0
SPPL2C	162540	broad.mit.edu	37	17	43922915	43922915	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:43922915C>T	ENST00000329196.5	+	1	660	c.643C>T	c.(643-645)Cgg>Tgg	p.R215W	MAPT-AS1_ENST00000579599.1_RNA|MAPT-AS1_ENST00000579244.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	215						integral to membrane	aspartic-type endopeptidase activity										CCGGCTACAGCGGCGCCGTGC	0.622000													22	41					0	0	1	0	0
LPAR5	57121	broad.mit.edu	37	12	6730347	6730347	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6730347C>T	ENST00000329858.4	-	2	824	c.68G>A	c.(67-69)cGc>cAc	p.R23H	LPAR5_ENST00000431922.1_Missense_Mutation_p.R23H|LPAR5_ENST00000540335.1_5'UTR	NM_020400.5	NP_065133.1	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	23						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7						CAAGTGCAGGCGGTGGGTAGG	0.632000													3	6					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25026729	25026729	+	Silent	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:25026729A>T	ENST00000381989.3	-	24	2934	c.2829T>A	c.(2827-2829)tcT>tcA	p.S943S		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	943	VWFA.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TAGGTGTGGCAGACTGGAGGA	0.468000													18	65					0	0	1	0	0
DAPK3	1613	broad.mit.edu	37	19	3964791	3964791	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3964791C>T	ENST00000545797.2	-	3	504	c.261G>A	c.(259-261)acG>acA	p.T87T	DAPK3_ENST00000301264.3_Silent_p.T87T			O43293	DAPK3_HUMAN	death-associated protein kinase 3	87	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|skin(2)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACCACGTCCGTCTTGTTCT	0.622000													8	40					0	0	1	0	0
CROT	54677	broad.mit.edu	37	7	86991077	86991077	+	Silent	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:86991077T>A	ENST00000331536.3	+	6	641	c.456T>A	c.(454-456)acT>acA	p.T152T	CROT_ENST00000419147.2_Silent_p.T180T|CROT_ENST00000442291.1_Silent_p.T152T	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	152					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TTGGAAATACTCCTCTAGATA	0.313000													45	61					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133402941	133402941	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:133402941G>A	ENST00000329321.3	+	2	1593	c.1124G>A	c.(1123-1125)cGc>cAc	p.R375H	GPR39_ENST00000470071.1_3'UTR|LYPD1_ENST00000397463.2_3'UTR	NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	375						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AAGCGCCTGCGCGTACATGCG	0.647000													15	35					0	0	1	0	0
HIATL1	84641	broad.mit.edu	37	9	97218567	97218567	+	Silent	SNP	G	G	A	rs144765011		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:97218567G>A	ENST00000375344.3	+	10	1343	c.1074G>A	c.(1072-1074)acG>acA	p.T358T	HIATL1_ENST00000428393.2_Intron	NM_032558.2	NP_115947.2	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	358					transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	11		Acute lymphoblastic leukemia(62;0.136)				CCAGCATCACGTTTCCGGCAA	0.572000													25	47					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34235617	34235617	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:34235617G>A	ENST00000587132.1	-	0	2410																											GCTTGTAGAGGCCTTCGGTTC	0.453000													12	32					0	0	1	0	0
SETD3	84193	broad.mit.edu	37	14	99865060	99865060	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:99865060C>T	ENST00000331768.5	-	13	1900	c.1741G>A	c.(1741-1743)Gcc>Acc	p.A581T		NM_032233.2	NP_115609.2	Q86TU7	SETD3_HUMAN	SET domain containing 3	581					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				GATCCTTTGGCGTCTTCAACT	0.488000													35	62					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135161826	135161826	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:135161826G>T	ENST00000372169.2	-	18	6562	c.6380C>A	c.(6379-6381)gCt>gAt	p.A2127D	SETX_ENST00000224140.5_Missense_Mutation_p.A2127D|SETX_ENST00000393220.1_Missense_Mutation_p.A2127D			Q7Z333	SETX_HUMAN	senataxin	2127					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		AATTTTAGAAGCAAGTTCCTG	0.294000													12	55					0.0931896	0.0936283	1	1	0
DNAH1	25981	broad.mit.edu	37	3	52429427	52429427	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52429427C>T	ENST00000420323.2	+	69	11333	c.11072C>T	c.(11071-11073)gCc>gTc	p.A3691V		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3756					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TACAAGTTTGCCGAAGAAATG	0.587000													5	18					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71965341	71965341	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:71965341G>A	ENST00000266674.5	+	12	1429	c.1118G>A	c.(1117-1119)tGc>tAc	p.C373Y	LGR5_ENST00000540815.2_Missense_Mutation_p.C349Y|LGR5_ENST00000536515.1_Missense_Mutation_p.C301Y			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	373						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TTTTCAGTCTGCCAAAAGCTT	0.353000													16	27					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139724415	139724415	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:139724415G>A	ENST00000263549.3	-	12	2924	c.2051C>T	c.(2050-2052)tCg>tTg	p.S684L		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	684	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					GGGTGTGACCGAGGGCTTGGA	0.562000													4	24					0	0	1	0	0
NBPF3	84224	broad.mit.edu	37	1	21795389	21795389	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:21795389C>T	ENST00000318220.6	+	6	1222	c.175_splice	c.e6+1	p.Y58_splice	NBPF3_ENST00000454000.2_Intron|NBPF3_ENST00000318249.5_Splice_Site_p.Y114_splice|NBPF3_ENST00000342104.5_Splice_Site_p.Y114_splice			Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	114						cytoplasm				breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	20		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AAAATAATTACGGTAAGTTCT	0.443000											OREG0013205	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	35					0	0	1	0	0
SLC5A5	6528	broad.mit.edu	37	19	17988624	17988624	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17988624C>T	ENST00000222248.3	+	6	1138	c.791C>T	c.(790-792)gCg>gTg	p.A264V		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	264					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						GTGAACCAGGCGCAGGTGCAG	0.607000													16	35					0	0	1	0	0
PSCA	8000	broad.mit.edu	37	8	143762788	143762788	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:143762788C>T	ENST00000301258.4	+	2	152	c.69C>T	c.(67-69)aaC>aaT	p.N23N	PSCA_ENST00000505305.1_3'UTR|PSCA_ENST00000513264.1_Silent_p.N23N	NM_005672.4	NP_005663.2	D3DWI6	D3DWI6_HUMAN	prostate stem cell antigen	23										endometrium(1)|large_intestine(1)	2	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					AGGTGAGCAACGAGGACTGCC	0.667000													5	7					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803109	185803109	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:185803109T>C	ENST00000302277.6	+	4	3580	c.2986T>C	c.(2986-2988)Tca>Cca	p.S996P		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	996						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GCGTTATAATTCAGGAATCCT	0.433000													46	61					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940801	144940801	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144940801C>T	ENST00000525985.1	-	2	6692	c.6621G>A	c.(6619-6621)acG>acA	p.T2207T				P58107	EPIPL_HUMAN	epiplakin 1	2207						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGAGCTCTTGCGTCGTGCTCC	0.622000													16	129					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60749095	60749095	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:60749095C>T	ENST00000303375.5	+	7	1605	c.1203C>T	c.(1201-1203)cgC>cgT	p.R401R		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	401	C-type lectin 2.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						CCGAGAAGCGCAGCTGGCAGG	0.627000													6	18					0	0	1	0	0
SLC25A16	8034	broad.mit.edu	37	10	70276515	70276515	+	Silent	SNP	C	C	T	rs144747524		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:70276515C>T	ENST00000265870.2	-	2	314	c.216G>A	c.(214-216)aaG>aaA	p.K72K	SLC25A16_ENST00000493963.1_5'UTR|SLC25A16_ENST00000539557.1_5'UTR	NM_152707.3	NP_689920.1	P16260	GDC_HUMAN	solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16	72					coenzyme biosynthetic process|pantothenate metabolic process	integral to membrane|mitochondrial inner membrane	binding|solute:solute antiporter activity			endometrium(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	7						CACCTAAATGCTTGTAATGGT	0.333000													12	20					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74708871	74708871	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:74708871C>T	ENST00000308807.7	-	10	1831	c.1368G>A	c.(1366-1368)cgG>cgA	p.R456R	MLKL_ENST00000306247.7_Silent_p.R248R	NM_152649.2	NP_689862.1	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like	456	Protein kinase.						ATP binding|protein binding|protein kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(6)|skin(1)|stomach(2)	19						CCACAGAGGGCCGCACAGAGG	0.547000													9	19					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132306038	132306038	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:132306038G>A	ENST00000331898.7	-	6	1457	c.879C>T	c.(877-879)aaC>aaT	p.N293N	OPCML_ENST00000524381.1_Silent_p.N286N|OPCML_ENST00000541867.1_Silent_p.N293N|OPCML_ENST00000374778.4_Silent_p.N252N|OPCML_ENST00000529038.1_5'UTR	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	293	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CACAAGTATAGTTCCCATAAT	0.488000													23	34					0	0	1	0	0
TCF19	6941	broad.mit.edu	37	6	31129716	31129716	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31129716C>T	ENST00000376257.3	+	3	1485	c.731C>T	c.(730-732)cCg>cTg	p.P244L	TCF19_ENST00000496421.1_3'UTR|TCF19_ENST00000376255.4_Missense_Mutation_p.P244L	NM_007109.2	NP_009040.2	Q9Y242	TCF19_HUMAN	transcription factor 19	244	Pro-rich.				cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						CCTGAGAACCCGCCACCGGTC	0.567000													19	22					0	0	1	0	0
RAD18	56852	broad.mit.edu	37	3	8988943	8988943	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:8988943C>T	ENST00000264926.2	-	4	343	c.227G>A	c.(226-228)cGc>cAc	p.R76H	RAD18_ENST00000495087.1_5'UTR	NM_020165.3	NP_064550.3	Q9NS91	RAD18_HUMAN	RAD18 homolog (S. cerevisiae)	76					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(3)	15				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		ATCTAATATGCGGTTATTTTT	0.323000								Rad6 pathway					35	62					0	0	1	0	0
TRAF7	84231	broad.mit.edu	37	16	2223318	2223318	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2223318G>T	ENST00000326181.6	+	10	1062	c.930G>T	c.(928-930)caG>caT	p.Q310H		NM_032271.2	NP_115647.2	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	310					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	23						AGAAGGACCAGGAGATCGCCT	0.612000													7	15					6.5536e-12	7.07361e-12	1	1	0
DIRC2	84925	broad.mit.edu	37	3	122552256	122552256	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:122552256C>T	ENST00000261038.5	+	4	1194	c.796C>T	c.(796-798)Cgg>Tgg	p.R266W		NM_032839.2	NP_116228.1	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	266					transport	integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|prostate(1)	18				GBM - Glioblastoma multiforme(114;0.0614)		AGCTAGCCAGCGGCTGAGTTA	0.433000													45	70					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112182470	112182470	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112182470G>A	ENST00000455480.2	+	14	2008	c.1831G>A	c.(1831-1833)Gaa>Aaa	p.E611K	ACAD10_ENST00000313698.4_Missense_Mutation_p.E580K|ACAD10_ENST00000549590.1_Missense_Mutation_p.E580K|ACAD10_ENST00000392636.2_Missense_Mutation_p.E182K|ACAD10_ENST00000413681.3_3'UTR	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	580							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CACATATGCGGAACAAACTGG	0.463000													31	53					0	0	1	0	0
RTN4	57142	broad.mit.edu	37	2	55254135	55254135	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:55254135T>A	ENST00000337526.6	-	3	1343	c.1100A>T	c.(1099-1101)gAc>gTc	p.D367V	RTN4_ENST00000394611.2_Missense_Mutation_p.D161V|RTN4_ENST00000405240.1_Missense_Mutation_p.D161V|RTN4_ENST00000404909.1_Missense_Mutation_p.D161V|RTN4_ENST00000357376.3_Missense_Mutation_p.D161V|RTN4_ENST00000317610.7_Intron|RTN4_ENST00000354474.6_Missense_Mutation_p.D135V|RTN4_ENST00000357732.4_Intron|RTN4_ENST00000402434.2_Intron	NM_020532.4	NP_065393.1	Q9NQC3	RTN4_HUMAN	reticulon 4	367					apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						ATTAAAACTGTCTTTTGCTTT	0.363000													31	46					0	0	1	0	0
ENTPD1	953	broad.mit.edu	37	10	97607363	97607363	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:97607363G>A	ENST00000371203.5	+	6	1147	c.560G>A	c.(559-561)tGc>tAc	p.C187Y	ENTPD1_ENST00000371207.3_Missense_Mutation_p.C337Y|ENTPD1_ENST00000453258.2_Missense_Mutation_p.C332Y|ENTPD1_ENST00000371205.4_Missense_Mutation_p.C325Y|ENTPD1_ENST00000539125.1_Missense_Mutation_p.C187Y|ENTPD1_ENST00000543964.1_Missense_Mutation_p.C217Y|RP11-429G19.3_ENST00000433113.1_RNA|ENTPD1-AS1_ENST00000416301.1_RNA	NM_001164179.1|NM_001164182.1|NM_001776.5	NP_001157651.1|NP_001157654.1|NP_001767.3	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	325					cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		TATCAACAATGCCATCAAAGC	0.473000													40	57					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1577960	1577960	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1577960C>T	ENST00000572621.1	-	20	3340	c.3075G>A	c.(3073-3075)acG>acA	p.T1025T	PRPF8_ENST00000304992.6_Silent_p.T1025T			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1025						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CATATGAATTCGTATGGTTCA	0.458000													27	139					0	0	1	0	0
KIAA1468	57614	broad.mit.edu	37	18	59949646	59949646	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:59949646C>T	ENST00000256858.6	+	26	3572	c.3324C>T	c.(3322-3324)ggC>ggT	p.G1108G	KIAA1468_ENST00000398130.2_Silent_p.G1074G			Q9P260	K1468_HUMAN	KIAA1468	1074							binding			autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				GTAGAGTTGGCCCTAACGCAG	0.408000													5	109					0	0	1	0	0
PCDHB5	0	broad.mit.edu	37	5	140516633	140516633	+	Silent	SNP	G	G	A	rs61745767		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140516633G>A	ENST00000231134.5	+	1	1834	c.1617G>A	c.(1615-1617)gcG>gcA	p.A539A		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		539	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCCCCGGCGCTGAGCAGCG	0.692000													21	32					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12203621	12203621	+	RNA	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:12203621T>C	ENST00000432424.2	+	0	1119							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						GACATCCGGGTCCAGAAGATT	0.502000													8	17					0	0	1	0	0
ASB1	51665	broad.mit.edu	37	2	239344527	239344527	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:239344527C>T	ENST00000264607.4	+	3	614	c.367C>T	c.(367-369)Cac>Tac	p.H123Y	ASB1_ENST00000409297.1_Intron	NM_001040445.1	NP_001035535.1	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box containing 1	123					intracellular signal transduction|negative regulation of cytokine biosynthetic process					breast(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		GGTGAACGGGCACCTAGAGAG	0.637000													5	18					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34130097	34130097	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:34130097C>T	ENST00000389232.4	+	89	11986	c.11916C>T	c.(11914-11916)gaC>gaT	p.D3972D	RYR3_ENST00000415757.3_Silent_p.D3967D	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3972					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATGAGAATGACATGTTTAATT	0.428000													37	53					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190445173	190445173	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190445173C>T	ENST00000261024.2	-	1	440	c.14G>A	c.(13-15)gGa>gAa	p.G5E	SLC40A1_ENST00000418714.1_5'UTR	NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	5					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			GTTGTGATCTCCCGCCCTGGT	0.572000													15	31					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106844139	106844139	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:106844139C>T	ENST00000276185.4	+	16	2969	c.2969C>T	c.(2968-2970)tCg>tTg	p.S990L				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	990						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GCCATCATCTCGGCCGCCCTA	0.602000													12	1					0	0	1	0	0
ACY1	95	broad.mit.edu	37	3	52011973	52011973	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52011973G>A	ENST00000458031.2	+	2	242	c.11G>A	c.(10-12)tGc>tAc	p.C4Y	ABHD14B_ENST00000483233.1_Intron|ABHD14A_ENST00000273596.3_Silent_p.L52L|ABHD14A-ACY1_ENST00000463937.1_Silent_p.L52L|ABHD14A_ENST00000491470.1_Silent_p.L52L			Q03154	ACY1_HUMAN	aminoacylase 1	0					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	ATGTGGGGCTGCCAGGCCCCC	0.627000													30	31					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39911459	39911459	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39911459G>A	ENST00000425673.1	+	13	1691	c.1366G>A	c.(1366-1368)Gct>Act	p.A456T	PLEKHG2_ENST00000378550.1_Missense_Mutation_p.A456T|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.A456T|PLEKHG2_ENST00000409797.2_Missense_Mutation_p.A456T|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.A397T			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	456					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			ACCTCGAGATGCTAGAAGTTT	0.602000													4	70					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544757	82544757	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:82544757G>A	ENST00000423517.2	-	7	12882	c.12545C>T	c.(12544-12546)gCc>gTc	p.A4182V	PCLO_ENST00000333891.8_Missense_Mutation_p.A4182V|PCLO_ENST00000437081.1_Missense_Mutation_p.A902V	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4113					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ATAAAGTATGGCTGCTGGCAG	0.363000													5	54					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	58965579	58965579	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:58965579G>A	ENST00000423743.3	+	28	4195	c.3937G>A	c.(3937-3939)Gga>Aga	p.G1313R	KIAA0586_ENST00000556134.1_Missense_Mutation_p.G1342R|KIAA0586_ENST00000354386.6_Missense_Mutation_p.G1410R|KIAA0586_ENST00000538571.2_3'UTR|KIAA0586_ENST00000261244.5_Missense_Mutation_p.G1281R	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	1281										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CATCTTAATGGGACATTCTCT	0.423000													12	17					0	0	1	0	0
CTSW	1521	broad.mit.edu	37	11	65650136	65650136	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65650136G>A	ENST00000528419.1	+	6	599	c.595G>A	c.(595-597)Gcg>Acg	p.A199T	CTSW_ENST00000307886.3_Missense_Mutation_p.A199T			P56202	CATW_HUMAN	cathepsin W	199					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(5)	9				READ - Rectum adenocarcinoma(159;0.168)		CGTCTGGGACGCGTTCATAAC	0.627000													8	34					0	0	1	0	0
BSCL2	26580	broad.mit.edu	37	11	62458343	62458343	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62458343C>T	ENST00000405837.1	-	10	1571	c.1075G>A	c.(1075-1077)Gca>Aca	p.A359T	BSCL2_ENST00000407022.3_Intron|BSCL2_ENST00000421906.1_Intron|RP11-831H9.16_ENST00000403734.2_Intron|BSCL2_ENST00000403550.1_Intron|BSCL2_ENST00000433053.1_Intron|BSCL2_ENST00000360796.5_Intron|BSCL2_ENST00000278893.7_Intron			Q96G97	BSCL2_HUMAN	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	293					cell death	integral to endoplasmic reticulum membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	12						TCAGGCCCTGCACCTCCAAAG	0.587000													9	11					0	0	1	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154987273	154987273	+	Missense_Mutation	SNP	G	G	A	rs140676784		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154987273G>A	ENST00000368426.3	+	3	274	c.137G>A	c.(136-138)cGc>cAc	p.R46H	ZBTB7B_ENST00000535420.1_Missense_Mutation_p.R46H|ZBTB7B_ENST00000487542.1_3'UTR|ZBTB7B_ENST00000292176.2_Missense_Mutation_p.R46H|ZBTB7B_ENST00000417934.2_Missense_Mutation_p.R80H	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	46	BTB.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CTTGAATACCGCACCCACAGG	0.632000													22	40					0	0	1	0	0
B3GNT5	84002	broad.mit.edu	37	3	182988041	182988041	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:182988041G>T	ENST00000326505.3	+	2	985	c.455G>T	c.(454-456)aGg>aTg	p.R152M	MCF2L2_ENST00000447025.2_Intron|MCF2L2_ENST00000473233.1_Intron|B3GNT5_ENST00000465010.1_Missense_Mutation_p.R152M|B3GNT5_ENST00000460419.1_Missense_Mutation_p.R152M|MCF2L2_ENST00000328913.3_Intron	NM_032047.4	NP_114436.1	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	152					central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GAAGATCAAAGGTACAATGAT	0.383000													19	23					1.67942e-08	1.77343e-08	1	1	0
TMEM144	55314	broad.mit.edu	37	4	159154132	159154132	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:159154132C>A	ENST00000514558.1	+	6	2289	c.493C>A	c.(493-495)Cat>Aat	p.H165N	TMEM144_ENST00000296529.6_Missense_Mutation_p.H165N			Q7Z5S9	TM144_HUMAN	transmembrane protein 144	165						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(7)|lung(9)|prostate(1)	19	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		AATAACAGAGCATGTGAGTAT	0.284000													23	34					1.66031e-10	1.77558e-10	1	1	0
IMMP1L	196294	broad.mit.edu	37	11	31484797	31484797	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:31484797G>T	ENST00000278200.1	-	3	222	c.27C>A	c.(25-27)acC>acA	p.T9T	IMMP1L_ENST00000532287.1_Silent_p.T9T|IMMP1L_ENST00000534812.1_Intron|IMMP1L_ENST00000528161.1_Intron|IMMP1L_ENST00000533642.1_Intron|IMMP1L_ENST00000526776.1_Silent_p.T9T	NM_144981.1	NP_659418.1	Q96LU5	IMP1L_HUMAN	IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)	9					proteolysis	mitochondrial inner membrane	serine-type peptidase activity			breast(1)|cervix(1)|large_intestine(1)|lung(4)	7	Lung SC(675;0.225)					CAAGTCGAAAGGTTTTCCCCA	0.363000													26	33					2.65835e-16	2.91848e-16	1	1	0
ZBTB44	29068	broad.mit.edu	37	11	130106968	130106968	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:130106968C>T	ENST00000525842.1	-	5	1655	c.1288G>A	c.(1288-1290)Gac>Aac	p.D430N	ZBTB44_ENST00000357899.4_Missense_Mutation_p.D430N|ZBTB44_ENST00000530205.1_Missense_Mutation_p.D430N|ZBTB44_ENST00000397753.1_Missense_Mutation_p.D430N	NM_014155.4	NP_054874.3	Q8NCP5	ZBT44_HUMAN	zinc finger and BTB domain containing 44	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	15	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0192)|Lung(977;0.235)		CCACAGCGGTCACACTGAAAT	0.373000													11	40					0	0	1	0	0
FAM124B	79843	broad.mit.edu	37	2	225266032	225266032	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:225266032C>T	ENST00000389874.3	-	1	679	c.454G>A	c.(454-456)Gcc>Acc	p.A152T	FAM124B_ENST00000409685.3_Missense_Mutation_p.A152T|FAM124B_ENST00000243806.2_Missense_Mutation_p.A152T	NM_024785.2	NP_079061.2	Q9H5Z6	F124B_HUMAN	family with sequence similarity 124B	152							protein binding	p.A152T(2)		endometrium(2)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	16		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		AGTCTGATGGCGTCTTCATAG	0.522000													17	43					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58600014	58600014	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:58600014G>A	ENST00000267485.7	-	3	1609	c.1415C>T	c.(1414-1416)gCc>gTc	p.A472V	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	472						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						GGATAAAGTGGCATCTGGCTC	0.428000													4	85					0	0	1	0	0
WDR18	57418	broad.mit.edu	37	19	990902	990902	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:990902G>A	ENST00000251289.5	+	5	671	c.648G>A	c.(646-648)gtG>gtA	p.V216V	WDR18_ENST00000587001.2_Silent_p.V216V	NM_024100.3	NP_077005.2	Q9BV38	WDR18_HUMAN	WD repeat domain 18	216										endometrium(1)|kidney(2)|lung(2)|skin(2)	7		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTTTGACGTGTCCATCATGG	0.647000													6	18					0	0	1	0	0
ZNF367	195828	broad.mit.edu	37	9	99154699	99154699	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:99154699C>T	ENST00000375256.4	-	4	1107	c.811G>A	c.(811-813)Gcg>Acg	p.A271T		NM_153695.3	NP_710162.1	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	271					regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(4)|large_intestine(3)|lung(3)|prostate(1)	12		Acute lymphoblastic leukemia(62;0.0167)				CACTCGGCCGCGGCCTTGTTG	0.622000													41	46					0	0	1	0	0
TJP2	9414	broad.mit.edu	37	9	71835923	71835923	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:71835923T>C	ENST00000377245.4	+	5	671	c.463T>C	c.(463-465)Tac>Cac	p.Y155H	TJP2_ENST00000535702.1_Missense_Mutation_p.Y159H|TJP2_ENST00000348208.4_Missense_Mutation_p.Y155H|TJP2_ENST00000265384.7_Missense_Mutation_p.Y155H|TJP2_ENST00000453658.2_Missense_Mutation_p.Y132H|TJP2_ENST00000539225.1_Missense_Mutation_p.Y186H	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	155					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						CCGGAGTGGCTACAGCGAGAG	0.672000													7	5					0	0	1	0	0
POU4F1	5457	broad.mit.edu	37	13	79176630	79176630	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:79176630C>T	ENST00000377208.5	-	2	391	c.180G>A	c.(178-180)gcG>gcA	p.A60A	RNF219-AS1_ENST00000560209.2_RNA|RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000560584.2_RNA	NM_006237.3	NP_006228.3	Q01851	PO4F1_HUMAN	POU class 4 homeobox 1	60					axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)	16		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		CGGCCGCCAGCGCCTCGGCCC	0.612000													8	4					0	0	1	0	0
RAB11B	9230	broad.mit.edu	37	19	8464808	8464808	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8464808C>T	ENST00000328024.6	+	2	320	c.102C>T	c.(100-102)aaC>aaT	p.N34N	RAB11B_ENST00000594216.1_Silent_p.N34N|RAB11B_ENST00000601897.1_Intron	NM_004218.3	NP_004209.2	Q15907	RB11B_HUMAN	RAB11B, member RAS oncogene family	34					cell cycle|protein transport|small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity			large_intestine(2)|lung(1)|ovary(1)	4						TCACCCGCAACGAGTTCAACC	0.632000													7	27					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51747269	51747269	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:51747269C>T	ENST00000395052.3	+	3	1465	c.1231C>T	c.(1231-1233)Cgg>Tgg	p.R411W	GRM2_ENST00000475478.1_Intron|GRM2_ENST00000442933.2_Missense_Mutation_p.R411W	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	411					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TGACGCGATGCGGCCAGTTAA	0.577000													5	14					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160969576	160969576	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:160969576C>A	ENST00000447678.1	-	32	5209	c.5089G>T	c.(5089-5091)Gaa>Taa	p.E1697*	LPA_ENST00000316300.5_Nonsense_Mutation_p.E1697*	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4205	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ACAGTCCCTTCTGTGTCTGAG	0.537000													31	51					4.62619e-21	5.13336e-21	1	1	0
MAG	4099	broad.mit.edu	37	19	35800807	35800807	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35800807G>A	ENST00000361922.4	+	8	1412	c.1262G>A	c.(1261-1263)tGc>tAc	p.C421Y	MAG_ENST00000537831.2_Missense_Mutation_p.C396Y|MAG_ENST00000392213.3_Missense_Mutation_p.C421Y|MAG_ENST00000593348.1_3'UTR	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	421	Ig-like C2-type 4.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GAGTCCCACTGCGCGGCAGCC	0.677000													35	52					0	0	1	0	0
AKR1B15	441282	broad.mit.edu	37	7	134250236	134250236	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:134250236G>A	ENST00000423958.1	+	1	4	c.4G>A	c.(4-6)Gcc>Acc	p.A2T	AKR1B15_ENST00000457545.2_Intron			C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	0							oxidoreductase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						ACCAACCATGGCCACGTTTGT	0.517000													4	31					0	0	1	0	0
ASMTL	8623	broad.mit.edu	37	X	1546862	1546862	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:1546862C>T	ENST00000534940.1	-	7	713	c.488G>A	c.(487-489)cGg>cAg	p.R163Q	ASMTL_ENST00000416733.2_Missense_Mutation_p.R145Q|ASMTL_ENST00000381317.3_Missense_Mutation_p.R221Q|ASMTL_ENST00000381333.4_Missense_Mutation_p.R205Q|ASMTL_ENST00000463763.1_5'UTR	NM_001173473.1	NP_001166944.1	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	221	MAF-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(9)|pancreas(1)|soft_tissue(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GACACTCCGCCGCAGGTCCTC	0.657000													9	15					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36340544	36340544	+	Missense_Mutation	SNP	C	C	T	rs114428177	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36340544C>T	ENST00000378910.5	-	6	619	c.620G>A	c.(619-621)cGg>cAg	p.R207Q	NPHS1_ENST00000353632.6_Missense_Mutation_p.R207Q	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	207	Ig-like C2-type 2.		TPR -> I (in NPHS1).		cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATCTGAGCTCCGGGGTGTCAC	0.542000													12	21					0	0	1	0	0
TTLL1	25809	broad.mit.edu	37	22	43442572	43442572	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:43442572G>A	ENST00000331018.7	-	9	1139	c.899C>T	c.(898-900)gCg>gTg	p.A300V	AL022476.2_ENST00000443063.1_RNA|TTLL1_ENST00000266254.7_Missense_Mutation_p.A329V			O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	329	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(1)	23		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		AGACGGGGACGCATTCACCTG	0.507000													23	40					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9033726	9033726	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9033726G>A	ENST00000397910.4	-	9	36414	c.36211C>T	c.(36211-36213)Cca>Tca	p.P12071S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12073	SEA 1.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACCATGAATGGGACTGTGGCT	0.532000													9	29					0	0	1	0	0
INSR	0	broad.mit.edu	37	19	7267687	7267687	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7267687C>T	ENST00000341500.5	-	2	360	c.321G>A	c.(319-321)acG>acA	p.T107T	INSR_ENST00000302850.5_Silent_p.T107T	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	107					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCCGGATGACCGTGAGGTTGG	0.527000													19	35					0	0	1	0	0
H3F3C	440093	broad.mit.edu	37	12	31944876	31944876	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:31944876C>T	ENST00000340398.3	-	1	299	c.225G>A	c.(223-225)gcG>gcA	p.A75A		NM_001013699.2	NP_001013721.2	Q6NXT2	H3C_HUMAN	H3 histone, family 3C	75					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	18						TGAAATCCTGCGCGATCTCCC	0.592000										HNSCC(67;0.2)			20	37					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52539084	52539084	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:52539084G>A	ENST00000242839.4	-	5	1949	c.1793C>T	c.(1792-1794)gCc>gTc	p.A598V	ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000418097.2_Missense_Mutation_p.A598V|ATP7B_ENST00000448424.2_Missense_Mutation_p.A598V|ATP7B_ENST00000542656.1_Intron|ATP7B_ENST00000344297.5_Missense_Mutation_p.A598V|ATP7B_ENST00000400370.3_Intron|ATP7B_ENST00000400366.3_Missense_Mutation_p.A487V	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	598	HMA 6.				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GGTGGCAAGGGCAACGGAGGC	0.448000									Wilson disease				36	58					0	0	1	0	0
IFNL2	282616	broad.mit.edu	37	19	39759403	39759403	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39759403G>A	ENST00000331982.5	+	2	152	c.97G>A	c.(97-99)Ggg>Agg	p.G33R		NM_172138.1	NP_742150.1			interferon, lambda 2																		CAGGCTCCACGGGGCTCTCCC	0.607000													14	16					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11700997	11700997	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:11700997G>C	ENST00000262442.3	+	43	8375	c.8307G>C	c.(8305-8307)atG>atC	p.M2769I	DNAH9_ENST00000454412.2_Missense_Mutation_p.M2769I	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2769					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCAAATACATGCCTGTACAGT	0.488000													11	21					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19181437	19181437	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:19181437C>T	ENST00000375371.3	-	3	548	c.527G>A	c.(526-528)cGc>cAc	p.R176H	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	176					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	AGCCGGGAAGCGCACCTTGTC	0.632000													8	21					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5541627	5541627	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:5541627C>T	ENST00000382368.3	-	3	396	c.273G>A	c.(271-273)gaG>gaA	p.E91E	FBXL18_ENST00000453700.3_Silent_p.E91E	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	91									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		CCCGGCCGATCTCCTTCACCA	0.652000													6	6					0	0	1	0	0
FASTKD2	22868	broad.mit.edu	37	2	207631944	207631944	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:207631944C>T	ENST00000236980.6	+	2	875	c.527C>T	c.(526-528)gCg>gTg	p.A176V	FASTKD2_ENST00000402774.3_Missense_Mutation_p.A176V|FASTKD2_ENST00000403094.3_Missense_Mutation_p.A176V	NM_014929.3	NP_055744.2	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	176					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(2)	21				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		TTTTCAAAAGCGCCCACATTT	0.408000													37	73					0	0	1	0	0
ZNF692	55657	broad.mit.edu	37	1	249144569	249144569	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:249144569C>T	ENST00000451251.1	-	12	1760	c.1415G>A	c.(1414-1416)cGt>cAt	p.R472H	ZNF692_ENST00000366469.5_Missense_Mutation_p.R466H|ZNF692_ENST00000427146.1_Missense_Mutation_p.R422H|ZNF692_ENST00000366471.3_Missense_Mutation_p.R422H|ZNF692_ENST00000306601.4_Missense_Mutation_p.R467H	NM_001136036.2	NP_001129508.1	Q9BU19	ZN692_HUMAN	zinc finger protein 692	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)	17	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			ACTTTTGCTACGGTGGGCTGC	0.617000													5	54					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82582023	82582023	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:82582023G>T	ENST00000423517.2	-	5	8583	c.8246C>A	c.(8245-8247)gCt>gAt	p.A2749D	PCLO_ENST00000333891.8_Missense_Mutation_p.A2749D	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2680					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CATTGTAGAAGCAGAAAGATC	0.343000													6	47					0.0215528	0.0217053	1	1	0
OXCT1	5019	broad.mit.edu	37	5	41805725	41805725	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:41805725T>C	ENST00000196371.5	-	9	1059	c.899A>G	c.(898-900)gAc>gGc	p.D300G	OXCT1_ENST00000509987.1_Missense_Mutation_p.D114G	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	300					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	TTCCCTTACGTCATCTCCAGG	0.443000													14	32					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46907409	46907409	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:46907409G>A	ENST00000359759.4	+	16	3148	c.3127G>A	c.(3127-3129)Gct>Act	p.A1043T	COL18A1_ENST00000400337.2_Missense_Mutation_p.A628T|COL18A1_ENST00000355480.5_Missense_Mutation_p.A808T			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	1043	Nonhelical region 4 (NC4).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		AGCCCGAAGCGCTGATGGGCC	0.642000													24	11					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11364876	11364876	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:11364876C>T	ENST00000304623.8	-	8	1493	c.1304G>A	c.(1303-1305)aGg>aAg	p.R435K	CTNND2_ENST00000359640.2_Missense_Mutation_p.R435K|CTNND2_ENST00000503622.1_Missense_Mutation_p.R98K|CTNND2_ENST00000458100.2_Missense_Mutation_p.R2K|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000511377.1_Missense_Mutation_p.R344K	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	435					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GCTGAGACTCCTCATAGGGGG	0.627000													5	19					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11052805	11052805	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:11052805G>A	ENST00000295082.1	+	1	743	c.253G>A	c.(253-255)Gcc>Acc	p.A85T		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	85						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GGACCCGGACGCCTTCAAGTG	0.562000													18	20					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52206155	52206155	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:52206155A>G	ENST00000282588.6	+	14	2221	c.1763A>G	c.(1762-1764)gAc>gGc	p.D588G		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	588					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GGATTTAATGACATCGTGATA	0.433000													14	21					0	0	1	0	0
TMOD3	29766	broad.mit.edu	37	15	52186107	52186107	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:52186107G>A	ENST00000308580.7	+	6	873	c.592G>A	c.(592-594)Gct>Act	p.A198T	RP11-56B16.5_ENST00000558142.1_RNA|TMOD3_ENST00000544199.1_Missense_Mutation_p.A198T	NM_014547.4	NP_055362.1	Q9NYL9	TMOD3_HUMAN	tropomodulin 3 (ubiquitous)	198						cytoplasm|cytoskeleton	actin binding|tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|stomach(1)	14				all cancers(107;0.00194)		AGAAAACGATGCTCATCTTGT	0.373000													32	53					0	0	1	0	0
PIGT	51604	broad.mit.edu	37	20	44049219	44049219	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:44049219G>A	ENST00000279036.6	+	8	999	c.919G>A	c.(919-921)Gtc>Atc	p.V307I	PIGT_ENST00000543458.2_Missense_Mutation_p.V251I|PIGT_ENST00000279035.9_Missense_Mutation_p.V205I|PIGT_ENST00000372689.5_Missense_Mutation_p.V307I|PIGT_ENST00000341555.5_Missense_Mutation_p.V113I|PIGT_ENST00000545755.1_Missense_Mutation_p.V45I|PIGT_ENST00000535404.1_Missense_Mutation_p.V152I	NM_015937.5	NP_057021.2	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class T	307					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(1)|endometrium(2)|kidney(5)|large_intestine(4)|lung(7)|pancreas(1)|skin(1)|stomach(1)	22		Myeloproliferative disorder(115;0.0122)				ATATCAGGACGTCATCCTAGG	0.532000													5	34					0	0	1	0	0
TMEM45B	120224	broad.mit.edu	37	11	129724588	129724588	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:129724588C>T	ENST00000281441.3	+	3	350	c.262C>T	c.(262-264)Cag>Tag	p.Q88*	TMEM45B_ENST00000524567.1_Nonsense_Mutation_p.Q88*	NM_138788.3	NP_620143.1	Q96B21	TM45B_HUMAN	transmembrane protein 45B	88						integral to membrane				endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)		AATGAATTGGCAGCACAGCAC	0.512000													22	19					0	0	1	0	0
ACSL1	2180	broad.mit.edu	37	4	185684393	185684393	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:185684393C>T	ENST00000515030.1	-	16	1774	c.1449G>A	c.(1447-1449)ccG>ccA	p.P483P	ACSL1_ENST00000454703.2_Silent_p.P312P|ACSL1_ENST00000504342.1_Silent_p.P483P|ACSL1_ENST00000513317.1_Silent_p.P483P|ACSL1_ENST00000507295.1_Silent_p.P449P|ACSL1_ENST00000437665.3_Silent_p.P312P|ACSL1_ENST00000281455.2_Silent_p.P483P			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	483					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGCACGGCATCGGGGCCCCAA	0.438000													11	21					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457205	45457205	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:45457205G>A	ENST00000548424.1	+	0	448																											GAGTACAGGTGCATCCTTTCT	0.393000													6	4					0	0	1	0	0
NOXRED1	122945	broad.mit.edu	37	14	77889171	77889171	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:77889171C>T	ENST00000380835.2	-	1	228	c.62G>A	c.(61-63)cGt>cAt	p.R21H	NOXRED1_ENST00000298358.3_Missense_Mutation_p.R21H	NM_001113475.2	NP_001106946.1	Q6NXP6	CN148_HUMAN	NADP-dependent oxidoreductase domain containing 1	21					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9						CAGCCAGATACGATCTTCCTC	0.478000													60	68					0	0	1	0	0
INSM1	3642	broad.mit.edu	37	20	20349842	20349842	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:20349842G>A	ENST00000310227.1	+	1	1078	c.931G>A	c.(931-933)Gcc>Acc	p.A311T		NM_002196.2	NP_002187.1	Q01101	INSM1_HUMAN	insulinoma-associated 1	311					endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			liver(1)|lung(3)|ovary(1)|prostate(1)	6				READ - Rectum adenocarcinoma(2;0.0649)		GGCCAACCTGGCCTCGCACCG	0.746000													3	5					0	0	1	0	0
LDLRAD2	401944	broad.mit.edu	37	1	22140900	22140900	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:22140900C>T	ENST00000344642.2	+	2	282	c.95C>T	c.(94-96)gCg>gTg	p.A32V	LDLRAD2_ENST00000543870.1_Missense_Mutation_p.A32V	NM_001013693.2	NP_001013715.2	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain containing 2	32						integral to membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)	6		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		GCCGACCTGGCGGAACTGTGC	0.692000													12	11					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64133336	64133336	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:64133336T>C	ENST00000295902.6	-	7	1415	c.830A>G	c.(829-831)cAt>cGt	p.H277R	PRICKLE2_ENST00000564377.1_Missense_Mutation_p.H333R	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	277	LIM zinc-binding 3.					cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CTCAGTGGCATGCCAGTGTTG	0.542000													27	42					0	0	1	0	0
RRAD	6236	broad.mit.edu	37	16	66956145	66956145	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:66956145C>T	ENST00000299759.6	-	5	1011	c.761G>A	c.(760-762)cGc>cAc	p.R254H	RRAD_ENST00000420652.1_Missense_Mutation_p.R254H			P55042	RAD_HUMAN	Ras-related associated with diabetes	254					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity	p.R254H(1)		endometrium(2)|kidney(4)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		GCTGTCCCTGCGCAGGCGTAT	0.592000													14	29					0	0	1	0	0
CA8	767	broad.mit.edu	37	8	61178597	61178597	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:61178597C>A	ENST00000317995.4	-	3	568	c.304G>T	c.(304-306)Gga>Tga	p.G102*		NM_004056.4	NP_004047.3	P35219	CAH8_HUMAN	carbonic anhydrase VIII	102					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(6)|prostate(2)|skin(1)	16		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				GGCAATGGTCCTCCCGAAAGA	0.383000													12	31					2.80697e-09	2.97546e-09	1	1	0
WHSC1	7468	broad.mit.edu	37	4	1961236	1961236	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1961236G>A	ENST00000382895.3	+	19	3455	c.3024G>A	c.(3022-3024)gcG>gcA	p.A1008A	WHSC1_ENST00000508803.1_Silent_p.A1008A|WHSC1_ENST00000382891.5_Silent_p.A1008A|WHSC1_ENST00000382892.2_Silent_p.A1008A|WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Silent_p.A356A	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	1008					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TCTACACAGCGGATATTTCAG	0.488000			T	IGH@	MM								17	19					0	0	1	0	0
FAM183B	340286	broad.mit.edu	37	7	38725623	38725623	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:38725623G>A	ENST00000409072.3	-	0	917									family with sequence similarity 183, member B											endometrium(1)|lung(7)	8						GGGCTGCTCCGTGGGTCCGGG	0.617000													17	15					0	0	1	0	0
NPY4R	0	broad.mit.edu	37	10	47087266	47087266	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:47087266G>A	ENST00000374312.1	+	3	902	c.483G>A	c.(481-483)gtG>gtA	p.V161V	NPY4R_ENST00000395716.1_Silent_p.V161V	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		TGGGGATTGTGCTCATCTGGG	0.582000													21	101					0	0	1	0	0
FUZ	80199	broad.mit.edu	37	19	50310485	50310485	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50310485G>A	ENST00000313777.4	-	11	1343	c.1180C>T	c.(1180-1182)Ctg>Ttg	p.L394L	FUZ_ENST00000533418.1_Silent_p.L344L|FUZ_ENST00000445575.2_Intron|FUZ_ENST00000528094.1_Silent_p.L358L	NM_025129.4	NP_079405.2	Q9BT04	FUZZY_HUMAN	fuzzy planar cell polarity protein	394	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		TGGGGAGACAGCAGCAGCAGC	0.637000													4	38					0	0	1	0	0
LRP3	4037	broad.mit.edu	37	19	33697049	33697049	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:33697049G>A	ENST00000253193.7	+	5	1575	c.1373G>A	c.(1372-1374)gGc>gAc	p.G458D		NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	458	LDL-receptor class A 4.			G -> D (in Ref. 4; BAG51998).	receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					TGCCAGCCCGGCACCTTCCAC	0.642000													8	3					0	0	1	0	0
SYT15	83849	broad.mit.edu	37	10	46967493	46967493	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:46967493C>T	ENST00000374323.3	-	3	1330	c.743G>A	c.(742-744)cGc>cAc	p.R248H	SYT15_ENST00000374321.4_Missense_Mutation_p.R195H|SYT15_ENST00000374325.3_Missense_Mutation_p.R195H|SYT15_ENST00000503753.1_Missense_Mutation_p.R195H			Q9BQS2	SYT15_HUMAN	synaptotagmin XV	195	C2 1.					integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						TTGGAGGAAGCGCCGCTCATC	0.612000													13	91					0	0	1	0	0
MSH3	4437	broad.mit.edu	37	5	79952260	79952260	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:79952260C>T	ENST00000265081.6	+	2	348	c.268C>T	c.(268-270)Cca>Tca	p.P90S		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	90	Interaction with EXO1.				maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		AAAGAAGAGACCATTGGAAAA	0.408000								Mismatch excision repair (MMR)					32	50					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126337678	126337678	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126337678G>A	ENST00000394329.3	+	6	6932	c.6919G>A	c.(6919-6921)Gct>Act	p.A2307T	FAT4_ENST00000335110.5_Missense_Mutation_p.A605T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2307	Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGAAGACAATGCTTTTACTCT	0.428000													15	113					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	35051201	35051201	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:35051201C>T	ENST00000360359.3	+	20	3053	c.2915C>T	c.(2914-2916)aCg>aTg	p.T972M	ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	972	PID.					cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						TAGAAATCTACGGAGCACATG	0.532000													14	56					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102742417	102742417	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:102742417C>A	ENST00000532855.1	-	0	628							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AGGATTCCACCTTTGCCATCA	0.443000													4	9					0.150653	0.151081	1	1	0
CRHR1	1394	broad.mit.edu	37	17	43907851	43907851	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:43907851C>T	ENST00000314537.5	+	7	849	c.624C>T	c.(622-624)ggC>ggT	p.G208G	CRHR1_ENST00000398285.3_Silent_p.G237G|CRHR1_ENST00000577353.1_Silent_p.G208G|CRHR1_ENST00000293493.7_Silent_p.G33G|CRHR1_ENST00000352855.5_Silent_p.G168G|CRHR1_ENST00000339069.5_Silent_p.G107G	NM_001145147.1|NM_001145148.1|NM_004382.4	NP_001138619.1|NP_001138620.1|NP_004373.2	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	237					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		GGATGTTCGGCGAGGGCTGCT	0.587000													34	47					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3755674	3755674	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:3755674G>A	ENST00000378230.3	-	8	1069	c.745C>T	c.(745-747)Cgc>Tgc	p.R249C		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	249						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						CTCCCAAGGCGTTCACCAACC	0.453000													32	52					0	0	1	0	0
TIMM50	92609	broad.mit.edu	37	19	39979204	39979204	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39979204C>T	ENST00000314349.4	+	10	1321	c.1188C>T	c.(1186-1188)gaC>gaT	p.D396D	TIMM50_ENST00000599794.1_Silent_p.D97D|TIMM50_ENST00000607714.1_Silent_p.D293D|TIMM50_ENST00000544017.1_Silent_p.D180D	NM_001001563.1	NP_001001563.1	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)	293					mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			NS(1)|endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)	14	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GTGTGGAGGACGTGCGAACCG	0.622000													26	132					0	0	1	0	0
BDNF	627	broad.mit.edu	37	11	27722532	27722532	+	Translation_Start_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:27722532C>A	ENST00000420794.1	-	0	68				BDNF_ENST00000395978.3_Intron|BDNF_ENST00000395983.3_De_novo_Start_OutOfFrame|BDNF_ENST00000525950.1_Intron|BDNF_ENST00000395980.2_Intron|BDNF_ENST00000584049.1_Intron|BDNF_ENST00000438929.1_De_novo_Start_OutOfFrame|BDNF_ENST00000314915.6_Intron|BDNF_ENST00000395981.3_Intron|RP11-587D21.4_ENST00000530663.1_RNA|BDNF_ENST00000532997.1_Intron	NM_001143811.1	NP_001137283.1	P23560	BDNF_HUMAN	brain-derived neurotrophic factor							extracellular region	growth factor activity			breast(1)|large_intestine(3)|lung(2)	6						CCGCACCTTCCTGCACTACGG	0.572000													5	7					8.12818e-05	8.34155e-05	1	1	0
CERS2	29956	broad.mit.edu	37	1	150940568	150940568	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:150940568C>T	ENST00000271688.6	-	4	787	c.401G>A	c.(400-402)cGa>cAa	p.R134Q	CERS2_ENST00000368954.5_Missense_Mutation_p.R134Q|CERS2_ENST00000345896.4_5'UTR|CERS2_ENST00000561294.1_Missense_Mutation_p.R125Q	NM_181746.3	NP_859530.1	Q96G23	CERS2_HUMAN	ceramide synthase 2	134	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CCTGGCTTCTCGGAACTTCTT	0.627000													24	37					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	58894966	58894966	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:58894966G>A	ENST00000354386.6	+	2	264	c.20G>A	c.(19-21)tGt>tAt	p.C7Y	KIAA0586_ENST00000556134.1_Intron|KIAA0586_ENST00000423743.3_Intron|KIAA0586_ENST00000261244.5_5'UTR	NM_001244189.1	NP_001231118.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	0										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TGTGGGACTTGTTTTGTGACC	0.363000													3	9					0	0	1	0	0
PSMD1	5707	broad.mit.edu	37	2	231943409	231943409	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:231943409G>A	ENST00000308696.6	+	10	1270	c.1108G>A	c.(1108-1110)Gtt>Att	p.V370I	PSMD1_ENST00000373635.4_Missense_Mutation_p.V370I|PSMD1_ENST00000409643.1_Missense_Mutation_p.V370I	NM_002807.3	NP_002798.2	Q99460	PSMD1_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	370					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)	31		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	TACTGCAACCGTTATAGCAAA	0.368000													41	79					0	0	1	0	0
RARA	0	broad.mit.edu	37	17	38508633	38508633	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38508633G>T	ENST00000254066.5	+	6	1136	c.681G>T	c.(679-681)aaG>aaT	p.K227N	RARA_ENST00000425707.3_Missense_Mutation_p.K130N|RARA_ENST00000420042.1_3'UTR|RARA_ENST00000394081.3_Missense_Mutation_p.K222N|RARA_ENST00000394086.3_Missense_Mutation_p.K243N|RARA_ENST00000394089.2_Missense_Mutation_p.K227N	NM_000964.3	NP_000955.1	P10276	RARA_HUMAN	retinoic acid receptor, alpha	227	Ligand-binding.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			breast(1)|kidney(4)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|urinary_tract(2)	16		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	TCTGGGACAAGTTCAGTGAAC	0.567000			T	"""PML, ZNF145, TIF1, NUMA1, NPM1"""	APL								36	60					9.73076e-26	1.08706e-25	1	1	0
GPSM2	29899	broad.mit.edu	37	1	109465125	109465125	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109465125T>C	ENST00000406462.1	+	14	2300	c.1527T>C	c.(1525-1527)tgT>tgC	p.C509C	GPSM2_ENST00000264126.3_Silent_p.C509C|AKNAD1_ENST00000357393.4_Intron			P81274	GPSM2_HUMAN	G-protein signaling modulator 2	509	GoLoco 1.				G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)	14		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		ATCAGAGATGTTGCTTACAAG	0.378000													42	72					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49582447	49582447	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:49582447C>A	ENST00000371175.4	-	5	786	c.760G>T	c.(760-762)Gcc>Tcc	p.A254S	RHAG_ENST00000229810.7_Missense_Mutation_p.A254S	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	254					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					AAGGCAAAGGCTGTGAGCACA	0.522000													9	55					0.000442599	0.000451009	1	1	0
CACNA1E	777	broad.mit.edu	37	1	181686338	181686338	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:181686338C>T	ENST00000526775.1	+	11	1590	c.1425C>T	c.(1423-1425)tcC>tcT	p.S475S	CACNA1E_ENST00000367570.1_Silent_p.S475S|CACNA1E_ENST00000360108.3_Silent_p.S475S|CACNA1E_ENST00000367567.4_Silent_p.S82S|CACNA1E_ENST00000367573.2_Silent_p.S475S|CACNA1E_ENST00000357570.5_Silent_p.S426S|CACNA1E_ENST00000358338.5_Silent_p.S426S	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	475					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TGGTTAAATCCCAGGTGTTTT	0.537000													22	27					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32056719	32056719	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32056719G>A	ENST00000375244.3	-	6	2823	c.2622C>T	c.(2620-2622)taC>taT	p.Y874Y	TNXB_ENST00000375247.2_Silent_p.Y874Y			P22105	TENX_HUMAN	tenascin XB	826					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CGGCACTGACGTAGGACACCA	0.622000													4	4					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78426039	78426039	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:78426039G>A	ENST00000370767.1	-	15	1573	c.1486C>T	c.(1486-1488)Ccg>Tcg	p.P496S	FUBP1_ENST00000370768.2_Missense_Mutation_p.P496S|FUBP1_ENST00000436586.2_Missense_Mutation_p.P517S			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	496	Pro-rich.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						TGAGGAGCCGGGCCTGGTGGT	0.522000			"""F, N"""		oligodendroglioma								9	19					0	0	1	0	0
RCCD1	91433	broad.mit.edu	37	15	91505006	91505006	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:91505006T>C	ENST00000556618.1	+	8	1258		c.e8+2		RCCD1_ENST00000555155.1_3'UTR|RCCD1_ENST00000394258.2_3'UTR			A6NED2	RCCD1_HUMAN	RCC1 domain containing 1											breast(1)|kidney(1)|large_intestine(2)	4	Lung NSC(78;0.0987)|all_lung(78;0.175)		Lung(145;0.189)			CTGACATGTGTACGTATATGT	0.502000													26	42					0	0	1	0	0
SLC6A16	28968	broad.mit.edu	37	19	49814513	49814513	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49814513G>A	ENST00000454748.3	-	2	293	c.92C>T	c.(91-93)aCg>aTg	p.T31M	SLC6A16_ENST00000335875.4_Missense_Mutation_p.T31M			Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	31						integral to membrane|intracellular	neurotransmitter:sodium symporter activity			NS(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		GTCTTCCCACGTTTGACTTCC	0.557000													35	25					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29976906	29976906	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:29976906C>T	ENST00000376797.3	-	0	773				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA																							TCTCACAGGACGTTTTCTTCC	0.507000													27	36					0	0	1	0	0
PIAS3	10401	broad.mit.edu	37	1	145578061	145578061	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145578061G>A	ENST00000393045.2	+	2	114		c.e2-1		PIAS3_ENST00000369299.3_Splice_Site|PIAS3_ENST00000369298.1_Splice_Site	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3						positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTTCTCCACAGCACATGGTGA	0.582000													27	57					0	0	1	0	0
PPP1R12C	54776	broad.mit.edu	37	19	55603041	55603041	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55603041C>T	ENST00000263433.3	-	21	2254	c.2239G>A	c.(2239-2241)Gca>Aca	p.A747T	PPP1R12C_ENST00000435544.2_Missense_Mutation_p.A672T|PPP1R12C_ENST00000376393.2_Missense_Mutation_p.A684T	NM_001271618.1|NM_017607.2	NP_001258547.1|NP_060077.1	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	747						cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	22			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		TCCAGCTCTGCGGCCTTGCGT	0.692000													3	9					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113478730	113478730	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113478730C>T	ENST00000487903.1	+	10	951	c.863C>T	c.(862-864)gCc>gTc	p.A288V	ATP11A_ENST00000375630.2_Missense_Mutation_p.A288V|ATP11A_ENST00000283558.8_Missense_Mutation_p.A288V|ATP11A_ENST00000375645.3_Missense_Mutation_p.A288V			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	288					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				AAGCGATCTGCCGTGGAAAAG	0.448000													27	28					0	0	1	0	0
DENND6B	414918	broad.mit.edu	37	22	50752652	50752652	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50752652G>A	ENST00000413817.2	-	13	1193	c.1122C>T	c.(1120-1122)acC>acT	p.T374T		NM_001001794.3	NP_001001794.3			DENN/MADD domain containing 6B																		TGGTGTCCAGGGTCTTCAACC	0.637000													7	6					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724474	38724474	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:38724474G>A	ENST00000342213.2	-	1	1100	c.754C>T	c.(754-756)Cgt>Tgt	p.R252C		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	252	EGF-like.					integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TTGCCAGCACGGAGGTACCTC	0.617000													38	62					0	0	1	0	0
ZNF454	285676	broad.mit.edu	37	5	178391870	178391870	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:178391870C>T	ENST00000320129.3	+	5	768	c.465C>T	c.(463-465)tcC>tcT	p.S155S	ZNF454_ENST00000519564.1_Silent_p.S155S	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		GTGATGAATCCGGGAGCACTA	0.493000													21	31					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935423	30935423	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:30935423C>T	ENST00000355537.3	+	2	1101	c.954C>T	c.(952-954)caC>caT	p.H318H		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TCATCAGCCACGTGGAGAAGG	0.667000													26	63					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71683419	71683419	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:71683419G>A	ENST00000393524.2	-	17	3878	c.3145C>T	c.(3145-3147)Cgg>Tgg	p.R1049W	PHLPP2_ENST00000356272.3_Missense_Mutation_p.R1116W|PHLPP2_ENST00000568954.1_Missense_Mutation_p.R1116W|PHLPP2_ENST00000540628.1_Intron|PHLPP2_ENST00000360429.3_Intron|PHLPP2_ENST00000567016.1_Missense_Mutation_p.R1151W			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	1116						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						CTGCAGCGCCGCTCTGGCCTC	0.597000													22	37					0	0	1	0	0
SP4	6671	broad.mit.edu	37	7	21550751	21550751	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:21550751C>T	ENST00000222584.3	+	6	2437	c.2219C>T	c.(2218-2220)gCc>gTc	p.A740V		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	740					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						ACAGCTCTTGCCATTGTTACC	0.458000													31	27					0	0	1	0	0
EHBP1	23301	broad.mit.edu	37	2	63058166	63058166	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:63058166G>A	ENST00000263991.5	+	7	989	c.507G>A	c.(505-507)atG>atA	p.M169I	AC007098.1_ENST00000452397.1_RNA|EHBP1_ENST00000405015.3_Missense_Mutation_p.M169I|EHBP1_ENST00000354487.3_Missense_Mutation_p.M169I|EHBP1_ENST00000431489.1_Missense_Mutation_p.M169I|EHBP1_ENST00000405289.1_Missense_Mutation_p.M169I	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	169						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			ATGAAGACATGCAAAGTTTGG	0.328000													27	30					0	0	1	0	0
HLX	3142	broad.mit.edu	37	1	221057957	221057957	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:221057957G>A	ENST00000366903.6	+	4	2879	c.1378G>A	c.(1378-1380)Gcc>Acc	p.A460T	HLX_ENST00000549319.1_Missense_Mutation_p.A246T	NM_021958.3	NP_068777.1	Q14774	HLX_HUMAN	H2.0-like homeobox	460					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(9)|lung(11)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(131;0.00914)		cggcggcggcGCCTCGGAGCT	0.657000													5	5					0	0	1	0	0
HAUS3	79441	broad.mit.edu	37	4	2242668	2242668	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2242668A>G	ENST00000243706.4	-	2	235	c.6T>C	c.(4-6)agT>agC	p.S2S	HAUS3_ENST00000506763.1_Silent_p.S2S|POLN_ENST00000511885.2_Intron|HAUS3_ENST00000443786.2_Silent_p.S2S|POLN_ENST00000515357.1_Intron	NM_024511.5	NP_078787.2	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	2					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						CATTTCCACAACTCATGGTTT	0.333000													30	36					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	106995083	106995083	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:106995083C>T	ENST00000357881.4	+	1	169	c.29C>T	c.(28-30)gCg>gTg	p.A10V	RFX4_ENST00000392842.1_Intron|RP11-144F15.1_ENST00000551505.1_Intron	NM_001206691.1	NP_001193620.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	0					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						CACCCTGGTGCGGGAGGCGAC	0.647000													5	16					0	0	1	0	0
TMEM116	89894	broad.mit.edu	37	12	112371728	112371728	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112371728C>T	ENST00000354825.3	-	11	1074	c.419G>A	c.(418-420)cGc>cAc	p.R140H	TMEM116_ENST00000550831.3_Missense_Mutation_p.R140H|TMEM116_ENST00000552374.2_Missense_Mutation_p.R232H|TMEM116_ENST00000549537.2_Missense_Mutation_p.R46H|TMEM116_ENST00000437003.2_Missense_Mutation_p.R140H|TMEM116_ENST00000355445.3_Missense_Mutation_p.R197H			Q8NCL8	TM116_HUMAN	transmembrane protein 116	140						integral to membrane		p.R140P(1)		endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(1)	8						TGGGTAGAAGCGCACCCGTTG	0.498000													6	50					0	0	1	0	0
CYP4V2	285440	broad.mit.edu	37	4	187130097	187130097	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:187130097G>A	ENST00000378802.4	+	9	1473	c.1169G>A	c.(1168-1170)cGc>cAc	p.R390H	CYP4V2_ENST00000502665.1_3'UTR	NM_207352.3	NP_997235.3	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily V, polypeptide 2	390					response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)|stomach(2)	20		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		GAGACCCTTCGCCTTTTTCCT	0.428000													10	59					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	91025225	91025225	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:91025225G>A	ENST00000268182.5	+	27	3487	c.3363G>A	c.(3361-3363)gcG>gcA	p.A1121A	IQGAP1_ENST00000560738.1_Silent_p.A549A	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1121	C1.|Ras-GAP.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CTGAGCAGGCGCTAGCTCATG	0.502000											OREG0023473	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	37					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2133780	2133780	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2133780C>T	ENST00000219476.3	+	33	4598	c.3968C>T	c.(3967-3969)gCg>gTg	p.A1323V	TSC2_ENST00000353929.4_Missense_Mutation_p.A1280V|TSC2_ENST00000350773.4_Missense_Mutation_p.A1300V|TSC2_ENST00000568454.1_Missense_Mutation_p.A1267V|TSC2_ENST00000439673.2_Missense_Mutation_p.A1220V|TSC2_ENST00000382538.6_Missense_Mutation_p.A1208V|TSC2_ENST00000401874.2_Missense_Mutation_p.A1256V	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	1323					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				GTTGAGGCAGCGCTAGGCATG	0.667000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				3	7					0	0	1	0	0
TRIM2	23321	broad.mit.edu	37	4	154215596	154215596	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:154215596C>T	ENST00000338700.5	+	5	810	c.745C>T	c.(745-747)Ctg>Ttg	p.L249L	TRIM2_ENST00000437508.2_Silent_p.L222L|TRIM2_ENST00000494872.1_3'UTR	NM_015271.3	NP_056086.2	Q9C040	TRIM2_HUMAN	tripartite motif containing 2	222						cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)	19	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		CAAGAGTGTGCTGCTTATGGA	0.433000													16	35					0	0	1	0	0
ARRB1	408	broad.mit.edu	37	11	74987953	74987953	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:74987953G>A	ENST00000420843.2	-	10	803	c.706C>T	c.(706-708)Cgc>Tgc	p.R236C	ARRB1_ENST00000360025.3_Missense_Mutation_p.R236C|ARRB1_ENST00000393505.4_Missense_Mutation_p.R236C	NM_004041.4	NP_004032.2	P49407	ARRB1_HUMAN	arrestin, beta 1	236					G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(4)|large_intestine(2)|lung(4)|prostate(1)	11						GCATACTGGCGCACTAGGGAG	0.567000													19	25					0	0	1	0	0
HIGD1A	25994	broad.mit.edu	37	3	42827562	42827562	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:42827562G>A	ENST00000321331.7	-	3	307	c.190C>T	c.(190-192)Cgt>Tgt	p.R64C	HIGD1A_ENST00000430190.1_Missense_Mutation_p.R64C|HIGD1A_ENST00000418900.2_Missense_Mutation_p.R64C|HIGD1A_ENST00000470543.1_5'UTR|HIGD1A_ENST00000452906.2_Missense_Mutation_p.R78C	NM_001099669.1|NM_014056.3	NP_001093139.1|NP_054775.2	Q9Y241	HIG1A_HUMAN	HIG1 hypoxia inducible domain family, member 1A	64	HIG1.				response to stress	integral to membrane|protein complex	protein binding			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.217)		GCTGCCACACGCATGTGGATC	0.378000													25	37					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227057	38227057	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:38227057G>A	ENST00000319637.6	-	3	936	c.870C>T	c.(868-870)ggC>ggT	p.G290G	EPHA10_ENST00000373048.4_Intron|EPHA10_ENST00000427468.2_Intron	NM_173641.2	NP_775912.2	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	0						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCACCCCACGGCCCCCAGCCA	0.662000													27	30					0	0	1	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148876466	148876466	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:148876466G>T	ENST00000336498.3	+	16	1630		c.e16-1		ARHGAP10_ENST00000414545.2_Splice_Site	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10						apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		TTTTCACACAGGAGTCTTCCA	0.328000													61	137					6.12789e-21	6.79748e-21	1	1	0
TMEM246	84302	broad.mit.edu	37	9	104238426	104238426	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:104238426G>A	ENST00000374851.1	-	4	2096	c.949C>T	c.(949-951)Cgg>Tgg	p.R317W	TMEM246_ENST00000374848.3_Missense_Mutation_p.R317W|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000424154.1_RNA|RP11-490D19.6_ENST00000431507.1_RNA|TMEM246_ENST00000374847.1_Missense_Mutation_p.R317W|RP11-490D19.6_ENST00000450109.1_RNA			Q9BRR3	CI125_HUMAN	transmembrane protein 246	317						integral to membrane											CTCAGCCGCCGCAGTTCCAGG	0.617000													14	37					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169209425	169209425	+	Silent	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:169209425A>T	ENST00000393743.3	-	9	1374	c.1083T>A	c.(1081-1083)acT>acA	p.T361T		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	361							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AAAATTCAAAAGTATGTATAT	0.249000													14	70					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45547935	45547935	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:45547935C>T	ENST00000291576.7	+	18	2390	c.2263C>T	c.(2263-2265)Cgc>Tgc	p.R755C	PWP2_ENST00000494310.1_3'UTR	NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	755						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CGAGGCACTGCGCCAGCAGGA	0.667000													5	18					0	0	1	0	0
DHRSX	207063	broad.mit.edu	37	X	2161252	2161252	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:2161252C>T	ENST00000334651.5	-	6	668	c.616G>A	c.(616-618)Gca>Aca	p.A206T		NM_145177.2	NP_660160.2	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	206							binding|oxidoreductase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)	16		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GCGTAGGCTGCGTGGGGTGAG	0.627000													10	22					0	0	1	0	0
ZBTB7A	51341	broad.mit.edu	37	19	4048173	4048173	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4048173G>A	ENST00000322357.4	-	3	1610	c.1332C>T	c.(1330-1332)ggC>ggT	p.G444G	ZBTB7A_ENST00000601588.1_Silent_p.G444G	NM_015898.2	NP_056982.1	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	444					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAAGGCGGCGCCGCACTGCT	0.662000													17	15					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11919742	11919742	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:11919742C>T	ENST00000256720.2	+	6	913	c.820C>T	c.(820-822)Ctg>Ttg	p.L274L	LPIN1_ENST00000396098.1_Silent_p.L316L|LPIN1_ENST00000449576.2_Silent_p.L359L|LPIN1_ENST00000396097.1_Silent_p.L4L|LPIN1_ENST00000425416.2_Silent_p.L280L|LPIN1_ENST00000396099.1_Silent_p.L316L	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	274					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		AATGCTTTGGCTGTGGGGAGA	0.483000											OREG0014444	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	36					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49721017	49721017	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49721017C>T	ENST00000551245.1	+	8	906	c.795C>T	c.(793-795)cgC>cgT	p.R265R	TROAP_ENST00000547923.1_5'UTR|TROAP_ENST00000257909.3_Silent_p.R265R			Q12815	TROAP_HUMAN	trophinin associated protein	265					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						AAGGAGAACGCGAGGTTGTCA	0.478000													28	43					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71146658	71146658	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:71146658C>T	ENST00000355527.3	-	9	1467	c.1191G>A	c.(1189-1191)tcG>tcA	p.S397S	DHCR7_ENST00000407721.2_Silent_p.S397S	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	397			S -> L (in SLOS).		cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	CCCAGAAGCCCGACACCAGCA	0.672000									Smith-Lemli-Opitz syndrome				8	9					0	0	1	0	0
RAD51	5888	broad.mit.edu	37	15	41020960	41020960	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:41020960G>A	ENST00000267868.3	+	7	850	c.582G>A	c.(580-582)gcG>gcA	p.A194A	RAD51_ENST00000382643.3_Silent_p.A195A|RAD51_ENST00000557850.1_Silent_p.A97A|RAD51_ENST00000532743.1_Silent_p.A195A|RAD51_ENST00000423169.2_Silent_p.A194A	NM_002875.4	NP_002866.2	Q06609	RAD51_HUMAN	RAD51 recombinase	194	Interaction with PALB2.				DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)|ovary(1)	9		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		ATGCTCGAGCGTTCAACACAG	0.448000								Homologous recombination					57	92					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23530582	23530582	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23530582G>A	ENST00000262710.1	-	17	3850	c.3523C>T	c.(3523-3525)Cgt>Tgt	p.R1175C	ACIN1_ENST00000338631.6_Missense_Mutation_p.R448C|ACIN1_ENST00000397341.3_Missense_Mutation_p.R417C|ACIN1_ENST00000557515.1_Missense_Mutation_p.R416C|ACIN1_ENST00000605057.1_Missense_Mutation_p.R1117C|ACIN1_ENST00000457657.1_Missense_Mutation_p.R1135C|ACIN1_ENST00000357481.2_Missense_Mutation_p.R417C|ACIN1_ENST00000555053.1_Missense_Mutation_p.R1162C	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1175	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GATCGGGAACGGGGCCCTTCT	0.577000													29	50					0	0	1	0	0
ZNF839	55778	broad.mit.edu	37	14	102792380	102792380	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:102792380C>T	ENST00000442396.2	+	2	362	c.347C>T	c.(346-348)cCa>cTa	p.P116L	ZNF839_ENST00000559185.1_5'UTR|ZNF839_ENST00000558850.1_5'UTR|ZNF839_ENST00000262236.5_5'UTR			A8K0R7	ZN839_HUMAN	zinc finger protein 839	0						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CAGGAAAGGCCAATGCTCCTA	0.517000													6	12					0	0	1	0	0
CRK	1398	broad.mit.edu	37	17	1340400	1340400	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1340400C>T	ENST00000300574.2	-	2	431	c.291G>A	c.(289-291)ttG>ttA	p.L97L	CRK_ENST00000574295.1_Silent_p.L97L|CRK_ENST00000572145.1_5'UTR|CRK_ENST00000398970.5_Silent_p.L97L	NM_016823.3	NP_058431.2	P46108	CRK_HUMAN	v-crk avian sarcoma virus CT10 oncogene homolog	97	SH2.				actin cytoskeleton organization|activation of MAPKK activity|blood coagulation|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of transcription from RNA polymerase II promoter	cytosol|endosome|nucleus|plasma membrane	protein binding|SH2 domain binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)	9				UCEC - Uterine corpus endometrioid carcinoma (25;0.083)		GTAAAGCAGGCAATGAATCAA	0.438000													14	44					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39227003	39227003	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:39227003G>A	ENST00000340369.3	-	2	4162	c.3934C>T	c.(3934-3936)Cca>Tca	p.P1312S	XIRP1_ENST00000421646.1_5'UTR|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1312	Pro-rich.						actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TCCAGTTTTGGGGTCTTTGTC	0.622000													23	33					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34023829	34023829	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:34023829C>T	ENST00000389232.4	+	48	7428	c.7358C>T	c.(7357-7359)tCc>tTc	p.S2453F	RYR3_ENST00000415757.3_Missense_Mutation_p.S2453F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2453	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TACAGGCTATCCAAGGGACGT	0.468000													3	23					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67325217	67325217	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67325217G>A	ENST00000304372.5	-	14	2615	c.2560C>T	c.(2560-2562)Ctg>Ttg	p.L854L		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	854						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CATACCCACAGCCGATTGGCC	0.557000													10	19					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17662249	17662249	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:17662249C>A	ENST00000262077.2	-	10	1267	c.1268_splice	c.e10+1	p.S423_splice	NUP153_ENST00000537253.1_Splice_Site_p.S423_splice	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	423					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			ATGACAGTACCTTTCTCGTTG	0.303000													31	47					2.08457e-15	2.28171e-15	1	1	0
MCF2L2	23101	broad.mit.edu	37	3	182946126	182946126	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:182946126C>T	ENST00000328913.3	-	18	2371	c.2074G>A	c.(2074-2076)Gct>Act	p.A692T	MCF2L2_ENST00000447025.2_Missense_Mutation_p.A692T|MCF2L2_ENST00000473233.1_Missense_Mutation_p.A692T	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	692	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GGGTTCTCAGCACACTTTTCC	0.323000													4	65					0	0	1	0	0
HAPLN1	1404	broad.mit.edu	37	5	82940427	82940427	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:82940427G>A	ENST00000274341.4	-	4	1380	c.530C>T	c.(529-531)gCg>gTg	p.A177V		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	177	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CGCCTGCTGCGCCTCGTGAAA	0.582000													17	6					0	0	1	0	0
TBC1D8	11138	broad.mit.edu	37	2	101644513	101644513	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:101644513G>A	ENST00000409318.1	-	14	2578	c.2448C>T	c.(2446-2448)aaC>aaT	p.N816N	TBC1D8_ENST00000376840.4_Silent_p.N801N	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	801					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						TACCCACCACGTTCTGCTTTG	0.537000													10	12					0	0	1	0	0
LEPROT	54741	broad.mit.edu	37	1	65895626	65895626	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:65895626C>T	ENST00000371065.4	+	3	312	c.174C>T	c.(172-174)gaC>gaT	p.D58D	LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371060.3_Intron|LEPR_ENST00000371059.3_Intron|LEPR_ENST00000349533.6_Intron|LEPR_ENST00000344610.8_Intron|LEPROT_ENST00000484243.1_3'UTR	NM_001198681.1|NM_017526.4	NP_001185610.1|NP_059996.1	O15243	OBRG_HUMAN	leptin receptor overlapping transcript	58						endosome membrane|Golgi membrane|integral to plasma membrane				kidney(1)|large_intestine(1)|lung(5)	7				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TCACCTATGACTCAGATGCAA	0.488000													68	95					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167133597	167133597	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:167133597G>T	ENST00000303354.6	-	16	3113	c.2773C>A	c.(2773-2775)Ctg>Atg	p.L925M	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.L913M|SCN9A_ENST00000375387.4_Missense_Mutation_p.L925M|SCN9A_ENST00000409435.1_Missense_Mutation_p.L924M			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	924						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TCTCCACACAGCACGCGGAAC	0.488000													5	118					0.000602214	0.000612743	1	1	0
C17orf74	201243	broad.mit.edu	37	17	7329619	7329619	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7329619G>T	ENST00000333870.3	+	3	383	c.309G>T	c.(307-309)caG>caT	p.Q103H	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_Intron	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	103						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				GACCCACGCAGTACTCCTCTT	0.607000													19	69					5.35356e-11	5.74024e-11	1	1	0
ZNF688	146542	broad.mit.edu	37	16	30581460	30581460	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30581460C>T	ENST00000223459.6	-	3	1712	c.608G>A	c.(607-609)cGc>cAc	p.R203H	ZNF688_ENST00000395219.1_Missense_Mutation_p.R189H	NM_145271.3	NP_660314.1	P0C7X2	ZN688_HUMAN	zinc finger protein 688	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)	8						CGAGTGCATGCGCCTGTGGCT	0.677000													16	14					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15690732	15690732	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:15690732G>T	ENST00000396368.3	-	27	5253	c.5047C>A	c.(5047-5049)Ctg>Atg	p.L1683M	KIAA0430_ENST00000551742.1_Missense_Mutation_p.L1683M|KIAA0430_ENST00000602337.1_Missense_Mutation_p.L1680M|KIAA0430_ENST00000548025.1_Missense_Mutation_p.L1680M|KIAA0430_ENST00000540441.2_Missense_Mutation_p.L1518M|KIAA0430_ENST00000344181.3_Missense_Mutation_p.L1371M	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	1682						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TCAGAGGTCAGAGTTTTGCTC	0.488000													6	33					0.00116845	0.0011864	1	1	0
TNFRSF10C	8794	broad.mit.edu	37	8	22974492	22974492	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22974492G>A	ENST00000356864.3	+	5	1260	c.728G>A	c.(727-729)tGc>tAc	p.C243Y	TNFRSF10C_ENST00000540813.1_Missense_Mutation_p.C141Y	NM_003841.3	NP_003832.2	O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	243					apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(6)|lung(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		TACCTCTCATGCACCATCGTA	0.493000													38	83					0	0	1	0	0
PSMC6	5706	broad.mit.edu	37	14	53185071	53185071	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:53185071G>A	ENST00000445930.2	+	9	763		c.e9+1		PSMC6_ENST00000606149.1_Splice_Site			P62333	PRS10_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 6						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)	19	Breast(41;0.176)					GATGCTATTGGTAAGAATAAC	0.313000													33	50					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16979632	16979632	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:16979632G>A	ENST00000377833.4	-	39	5950	c.5885C>T	c.(5884-5886)gCa>gTa	p.A1962V		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1962	CUB 13.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGCATCCACTGCAAACCACTC	0.423000													21	32					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116346414	116346414	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:116346414G>A	ENST00000374140.2	+	21	2931	c.2722G>A	c.(2722-2724)Gga>Aga	p.G908R	RP11-168K11.2_ENST00000428429.1_RNA|RGS3_ENST00000343817.5_Missense_Mutation_p.G627R|RGS3_ENST00000394646.3_Intron|RGS3_ENST00000342620.5_Intron|RGS3_ENST00000462143.1_Missense_Mutation_p.G229R|RGS3_ENST00000374134.3_Missense_Mutation_p.G229R|RGS3_ENST00000350696.5_Missense_Mutation_p.G908R	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	908					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						TGACAACTACGGAGAGCGCAG	0.657000													10	19					0	0	1	0	0
ZNF48	197407	broad.mit.edu	37	16	30409209	30409209	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30409209C>T	ENST00000320159.2	+	2	1014	c.638C>T	c.(637-639)aCa>aTa	p.T213I		NM_001214906.1|NM_001214907.1|NM_001214909.1|NM_152652.2	NP_001201835.1|NP_001201836.1|NP_001201838.1|NP_689865.2	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(11)|ovary(2)|pancreas(1)|skin(1)	21						CACCAGCGGACACACACTGGT	0.602000													14	18					0	0	1	0	0
GSN	2934	broad.mit.edu	37	9	124079467	124079467	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:124079467G>A	ENST00000373823.3	+	15	1762	c.857G>A	c.(856-858)gGc>gAc	p.G286D	GSN_ENST00000373818.4_Missense_Mutation_p.G337D|GSN_ENST00000545652.1_Missense_Mutation_p.G294D|GSN_ENST00000373808.2_Missense_Mutation_p.G286D|GSN_ENST00000373807.1_Missense_Mutation_p.G68D|GSN_ENST00000412819.1_Missense_Mutation_p.G286D|GSN_ENST00000449733.1_Missense_Mutation_p.G286D|GSN_ENST00000485767.1_3'UTR|GSN_ENST00000341272.2_Missense_Mutation_p.G286D|GSN_ENST00000436847.1_Missense_Mutation_p.G297D|GSN_ENST00000394353.2_Missense_Mutation_p.G297D			P06396	GELS_HUMAN	gelsolin	337					actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						CTGGACCACGGCAAAGATGGG	0.567000													35	66					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126749233	126749233	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:126749233C>T	ENST00000251772.4	+	28	5209	c.5140C>T	c.(5140-5142)Cgc>Tgc	p.R1714C	PLXNA1_ENST00000393409.2_Missense_Mutation_p.R1737C			Q9UIW2	PLXA1_HUMAN	plexin A1	1737					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		TGCTGACGTGCGCCACACCTG	0.642000													6	52					0	0	1	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35900535	35900535	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:35900535G>A	ENST00000325722.3	-	21	3344	c.3110C>T	c.(3109-3111)aCc>aTc	p.T1037I	KIAA0319L_ENST00000373266.4_Missense_Mutation_p.T474I	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	1037						cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTTCAGAGGGGTCTGCCCGTT	0.617000													8	23					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196963273	196963273	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:196963273A>G	ENST00000367414.5	+	4	622	c.566A>G	c.(565-567)tAc>tGc	p.Y189C	CFHR5_ENST00000256785.4_Missense_Mutation_p.Y165C	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	165	Sushi 3.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						AAAGAAAGCTACAAAGTTGGA	0.333000													33	51					0	0	1	0	0
SBDS	51119	broad.mit.edu	37	7	66458255	66458255	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:66458255G>T	ENST00000246868.2	-	3	591	c.408C>A	c.(406-408)gcC>gcA	p.A136A		NM_016038.2	NP_057122.2	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome	136					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			cervix(1)|endometrium(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	7						TGTCCTTCATGGCTCTCTCAA	0.413000			Gene Conversion			"""AML, MDS"""			Shwachman-Diamond syndrome				67	123					1.93348e-29	2.16538e-29	1	1	0
BCHE	590	broad.mit.edu	37	3	165548402	165548402	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:165548402C>T	ENST00000264381.3	-	2	586	c.420G>A	c.(418-420)tgG>tgA	p.W140*	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	140					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	CACCATAAATCCATATCAATA	0.383000													24	48					0	0	1	0	0
PHOX2B	8929	broad.mit.edu	37	4	41748140	41748140	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:41748140G>A	ENST00000226382.2	-	3	988	c.629C>T	c.(628-630)gCg>gTg	p.A210V		NM_003924.3	NP_003915.2	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	210					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity	p.A210V(1)		autonomic_ganglia(7)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	30						gccTCCATTCGCCCCGCAGCT	0.756000			"""Mis, F"""		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				19	32					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45905189	45905189	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:45905189G>A	ENST00000311275.7	-	11	1542	c.1289C>T	c.(1288-1290)cCg>cTg	p.P430L	ZMYND8_ENST00000352431.2_Missense_Mutation_p.P450L|ZMYND8_ENST00000540497.1_Missense_Mutation_p.P425L|ZMYND8_ENST00000458360.2_Missense_Mutation_p.P425L|ZMYND8_ENST00000396281.4_Missense_Mutation_p.P430L|ZMYND8_ENST00000262975.4_Missense_Mutation_p.P430L|ZMYND8_ENST00000536340.1_Missense_Mutation_p.P457L|ZMYND8_ENST00000471951.2_Missense_Mutation_p.P450L|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000355972.4_Missense_Mutation_p.P430L|ZMYND8_ENST00000372023.3_Missense_Mutation_p.P425L|ZMYND8_ENST00000360911.3_Missense_Mutation_p.P425L|ZMYND8_ENST00000461685.1_Missense_Mutation_p.P450L|ZMYND8_ENST00000446994.2_Missense_Mutation_p.P367L			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	430							protein binding|zinc ion binding	p.P450L(1)		NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GGGGGAGCGCGGCATATCCGA	0.597000													18	31					0	0	1	0	0
IHH	3549	broad.mit.edu	37	2	219925158	219925158	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219925158T>C	ENST00000295731.5	-	1	31	c.32A>G	c.(31-33)cAc>cGc	p.H11R		NM_002181.3	NP_002172.2	Q14623	IHH_HUMAN	indian hedgehog	11					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGGCAGAAGTGCAGTCGGGG	0.761000													5	5					0	0	1	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86916274	86916274	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:86916274C>T	ENST00000395184.1	+	9	1933	c.1467C>T	c.(1465-1467)agC>agT	p.S489S	ARHGAP24_ENST00000264343.4_Silent_p.S396S|ARHGAP24_ENST00000395183.2_Silent_p.S394S	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24	489					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		TTTTGAACAGCGACACACTCG	0.512000													16	35					0	0	1	0	0
AP1AR	55435	broad.mit.edu	37	4	113184195	113184195	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:113184195G>A	ENST00000274000.5	+	6	689	c.334G>A	c.(334-336)Gca>Aca	p.A112T	AP1AR_ENST00000309703.6_Intron	NM_018569.4	NP_061039.3	Q63HQ0	AP1AR_HUMAN	adaptor-related protein complex 1 associated regulatory protein	112	Interaction with AP1G1.				protein transport	early endosome|Golgi apparatus|late endosome|transport vesicle				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)	9						TTTATACGCTGCACAGCGTGA	0.423000													11	15					0	0	1	0	0
HS6ST1	9394	broad.mit.edu	37	2	129026327	129026327	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:129026327C>T	ENST00000259241.6	-	2	658	c.645G>A	c.(643-645)acG>acA	p.T215T		NM_004807.2	NP_004798.3	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	215					heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity	p.T215T(1)		endometrium(3)|liver(1)|lung(7)|pancreas(1)|prostate(2)|skin(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		CAGGCGTGGGCGTGCGCCCAT	0.652000													22	25					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10426938	10426938	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:10426938C>T	ENST00000245503.5	-	37	5731	c.5347G>A	c.(5347-5349)Gcc>Acc	p.A1783T	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.A1783T	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1783					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.A1783T(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TCCAGGTGGGCGCTGGTGTCC	0.512000													21	93					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12969611	12969611	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12969611C>T	ENST00000591495.1	+	13	1429	c.1412C>T	c.(1411-1413)gCg>gTg	p.A471V	MAST1_ENST00000251472.4_Intron			Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	0	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						GTCAGGGCTGCGGGGTGGCCT	0.547000													8	9					0	0	1	0	0
FGF10	2255	broad.mit.edu	37	5	44388600	44388600	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:44388600C>T	ENST00000264664.4	-	1	299	c.185G>A	c.(184-186)aGc>aAc	p.S62N		NM_004465.1	NP_004456.1	O15520	FGF10_HUMAN	fibroblast growth factor 10	62	Poly-Ser.				actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			haematopoietic_and_lymphoid_tissue(1)|lung(11)|skin(1)	13	Lung NSC(6;1.12e-06)					CCTTCCCGCGCTGGAAGGAGA	0.527000													15	21					0	0	1	0	0
TMCC3	57458	broad.mit.edu	37	12	94975842	94975842	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:94975842C>T	ENST00000261226.4	-	2	682	c.551G>A	c.(550-552)aGc>aAc	p.S184N	TMCC3_ENST00000551457.1_Missense_Mutation_p.S153N	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	184						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						GCCCGATTTGCTGCTCTCCAT	0.498000													14	88					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63065164	63065164	+	Silent	SNP	G	G	A	rs146046305	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:63065164G>A	ENST00000544661.1	+	5	758	c.330G>A	c.(328-330)gcG>gcA	p.A110A	SLC22A10_ENST00000332793.6_Silent_p.A265A|SLC22A10_ENST00000526800.1_Intron|SLC22A10_ENST00000525620.1_3'UTR|SLC22A10_ENST00000535888.1_Silent_p.A55A			Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	265						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						ACGTGGTGGCGTCTGTACCTT	0.443000													40	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179435501	179435501	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179435501T>C	ENST00000589042.1	-	326	75582	c.75358A>G	c.(75358-75360)Aca>Gca	p.T25120A	TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.T16247A|TTN_ENST00000591111.1_Missense_Mutation_p.T23479A|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.T16055A|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.T22552A|TTN_ENST00000359218.5_Missense_Mutation_p.T16180A|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23479	Fibronectin type-III 82.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCACGATTGTGTCTTTGTAT	0.423000													40	71					0	0	1	0	0
WDR65	149465	broad.mit.edu	37	1	43672498	43672498	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43672498C>T	ENST00000372492.4	+	10	1974	c.1650C>T	c.(1648-1650)tgC>tgT	p.C550C	WDR65_ENST00000528956.1_Silent_p.C550C	NM_001195831.2	NP_001182760.2	Q96MR6	WDR65_HUMAN	WD repeat domain 65	550										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGACAGAATGCGTGCTCAAGT	0.458000													17	72					0	0	1	0	0
SCIN	85477	broad.mit.edu	37	7	12679999	12679999	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:12679999G>A	ENST00000297029.5	+	11	1539	c.1438G>A	c.(1438-1440)Gtt>Att	p.V480I	SCIN_ENST00000445618.2_Missense_Mutation_p.V233I|SCIN_ENST00000519209.1_Missense_Mutation_p.V233I	NM_001112706.2	NP_001106177.1	Q9Y6U3	ADSV_HUMAN	scinderin	480	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	17				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CAAAGAGCCTGTTCACCTACT	0.443000													11	24					0	0	1	0	0
LDHB	3945	broad.mit.edu	37	12	21790097	21790097	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:21790097T>C	ENST00000396076.1	-	7	1077	c.745A>G	c.(745-747)Acc>Gcc	p.T249A	LDHB_ENST00000350669.1_Missense_Mutation_p.T249A	NM_001174097.1	NP_001167568.1	P07195	LDHB_HUMAN	lactate dehydrogenase B	249					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	26					NADH(DB00157)	GCCCAGTTGGTATATCCTTTT	0.348000													26	57					0	0	1	0	0
SCUBE3	222663	broad.mit.edu	37	6	35205730	35205730	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:35205730C>T	ENST00000274938.7	+	7	764	c.764C>T	c.(763-765)gCg>gTg	p.A255V	SCUBE3_ENST00000394681.1_Missense_Mutation_p.A271V	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	255	EGF-like 6.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						CATGATGCAGCGACTGGTGTC	0.552000													21	43					0	0	1	0	0
PSMD14	10213	broad.mit.edu	37	2	162224311	162224311	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:162224311G>A	ENST00000409682.3	+	5	841	c.137G>A	c.(136-138)cGt>cAt	p.R46H		NM_005805.5	NP_005796.1	O00487	PSDE_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	46	MPN.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K63-linked deubiquitination|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	endopeptidase activator activity|metal ion binding|metallopeptidase activity|proteasome binding|ubiquitin thiolesterase activity	p.R46H(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(2)	12						AAACATGGCCGTGCTGGAGTT	0.388000													7	14					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34123626	34123626	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:34123626G>A	ENST00000373381.4	-	27	4543	c.4367C>T	c.(4366-4368)gCg>gTg	p.A1456V	CSMD2_ENST00000373380.1_Missense_Mutation_p.A329V|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1416	CUB 9.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TCCCTGCAGCGCGTAGCCAGG	0.592000													13	57					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5489101	5489101	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:5489101G>A	ENST00000341928.2	-	2	422	c.82C>T	c.(82-84)Cgc>Tgc	p.R28C	EPB41L3_ENST00000400111.3_Missense_Mutation_p.R28C|EPB41L3_ENST00000544123.1_Missense_Mutation_p.R28C|EPB41L3_ENST00000342933.3_Missense_Mutation_p.R28C|EPB41L3_ENST00000540638.2_Missense_Mutation_p.R28C	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	28					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						gcccccgcgcgcccctgcgcc	0.716000													12	13					0	0	1	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100589123	100589123	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:100589123G>A	ENST00000268070.4	-	18	2635	c.2530C>T	c.(2530-2532)Cct>Tct	p.P844S		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	844	TSP type-1 2.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CTTGCTTGAGGGCAGTCACTG	0.577000													16	47					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53612554	53612554	+	Silent	SNP	C	C	T	rs145985814		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53612554C>T	ENST00000455735.2	-	7	1208	c.888G>A	c.(886-888)ctG>ctA	p.L296L	ZNF415_ENST00000243643.4_Silent_p.L248L|ZNF415_ENST00000595193.1_3'UTR|ZNF415_ENST00000597748.1_3'UTR|ZNF415_ENST00000601493.1_Silent_p.L18L|ZNF415_ENST00000597503.1_3'UTR|ZNF415_ENST00000594011.1_3'UTR|ZNF415_ENST00000500065.4_Silent_p.L248L|ZNF415_ENST00000448501.1_Silent_p.L296L|ZNF415_ENST00000440291.1_Silent_p.L235L|ZNF415_ENST00000421033.1_Silent_p.L260L			Q09FC8	ZN415_HUMAN	zinc finger protein 415	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		CCTTGCCACACAGATCACATT	0.398000													15	71					0	0	1	0	0
TPP1	1200	broad.mit.edu	37	11	6640450	6640450	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6640450G>A	ENST00000299427.6	-	2	126	c.66C>T	c.(64-66)agC>agT	p.S22S	TPP1_ENST00000528657.1_Silent_p.S22S|TPP1_ENST00000534644.1_5'UTR|RP11-732A19.9_ENST00000545572.1_RNA|TPP1_ENST00000533371.1_5'UTR	NM_000391.3	NP_000382.3	O14773	TPP1_HUMAN	tripeptidyl peptidase I	22					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		CGGGCTCCGGGCTGTAACTGC	0.592000													11	19					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50226672	50226672	+	Silent	SNP	G	G	A	rs148713102		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:50226672G>A	ENST00000338821.5	-	24	2868	c.2604C>T	c.(2602-2604)tcC>tcT	p.S868S	ATP9A_ENST00000402822.1_Silent_p.S747S|ATP9A_ENST00000311637.5_Silent_p.S732S	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	868					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						AGAGAGGGACGGAGGCAAAGT	0.413000													11	14					0	0	1	0	0
MAL2	114569	broad.mit.edu	37	8	120233895	120233895	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:120233895G>A	ENST00000276681.6	+	3	303	c.201G>A	c.(199-201)tgG>tgA	p.W67*	MAL2_ENST00000521748.1_3'UTR|RP11-4K16.2_ENST00000522828.1_lincRNA	NM_052886.2	NP_443118.1	Q969L2	MAL2_HUMAN	mal, T-cell differentiation protein 2 (gene/pseudogene)	67	MARVEL.					apical plasma membrane|endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding					all_cancers(13;1.91e-26)|Lung NSC(37;8.61e-08)|Ovarian(258;0.018)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000967)			TACAAGGATGGGTCATGTTTG	0.473000													28	133					0	0	1	0	0
KRT16	3868	broad.mit.edu	37	17	39768714	39768714	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39768714C>T	ENST00000301653.4	-	1	291	c.227G>A	c.(226-228)aGc>aAc	p.S76N		NM_005557.3	NP_005548.2	P08779	K1C16_HUMAN	keratin 16	76	Head.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				accaAAGCTGCTGCTGCTGCT	0.657000													4	3					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164393426	164393426	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:164393426T>C	ENST00000280605.3	-	1	1621	c.1461A>G	c.(1459-1461)ccA>ccG	p.P487P		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	487						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AATTTTCTTGTGGGGTATAAA	0.463000													36	48					0	0	1	0	0
ZCWPW2	152098	broad.mit.edu	37	3	28562551	28562551	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:28562551G>A	ENST00000383768.2	+	9	1041	c.853G>A	c.(853-855)Gcc>Acc	p.A285T	ZCWPW2_ENST00000421010.1_Missense_Mutation_p.A285T			Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	285							zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(6)|ovary(2)	17						GCAACCCACAGCCACACCTGA	0.368000													10	16					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31236825	31236825	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:31236825C>T	ENST00000251758.5	+	3	474	c.223C>T	c.(223-225)Cga>Tga	p.R75*	DDX11_ENST00000542838.1_Nonsense_Mutation_p.R75*|DDX11_ENST00000407793.2_Nonsense_Mutation_p.R75*|DDX11_ENST00000545668.1_Nonsense_Mutation_p.R75*|DDX11_ENST00000350437.4_Nonsense_Mutation_p.R75*|DDX11_ENST00000228264.6_Nonsense_Mutation_p.R49*			Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	75	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					AGAAGAGGCACGACTCCTTGA	0.517000										Multiple Myeloma(12;0.14)			21	38					0	0	1	0	0
UNC119B	84747	broad.mit.edu	37	12	121151157	121151157	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:121151157G>A	ENST00000344651.4	+	2	365	c.325G>A	c.(325-327)Gta>Ata	p.V109I	UNC119B_ENST00000539658.1_3'UTR	NM_001080533.1	NP_001074002.1	A6NIH7	U119B_HUMAN	unc-119 homolog B (C. elegans)	109										breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)	9	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GACAGGGACAGTACTTTTTGA	0.398000											OREG0022197	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	65					0	0	1	0	0
FUT4	2526	broad.mit.edu	37	11	94278738	94278738	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:94278738C>T	ENST00000358752.2	+	1	1722	c.1439C>T	c.(1438-1440)gCg>gTg	p.A480V	RP11-867G2.8_ENST00000536540.1_RNA	NM_002033.3	NP_002024.1	P22083	FUT4_HUMAN	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	480					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			central_nervous_system(2)|endometrium(2)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CGCAACCCCGCGGTCTATCGC	0.647000													21	31					0	0	1	0	0
IMPACT	55364	broad.mit.edu	37	18	22028078	22028078	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:22028078G>T	ENST00000284202.4	+	9	831	c.690G>T	c.(688-690)caG>caT	p.Q230H		NM_018439.3	NP_060909.1	Q9P2X3	IMPCT_HUMAN	impact RWD domain protein	230								p.Q230H(1)		endometrium(1)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)					AGGATAAACAGACCTTCTTAC	0.353000													33	38					2.32173e-10	2.48086e-10	1	1	0
MEGF8	1954	broad.mit.edu	37	19	42848911	42848911	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42848911G>A	ENST00000334370.4	+	12	2658	c.2023G>A	c.(2023-2025)Gtc>Atc	p.V675I	MEGF8_ENST00000251268.6_Missense_Mutation_p.V675I	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	725						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GGAGGCCTGCGTCACCCAGAG	0.662000													35	57					0	0	1	0	0
TRAF6	7189	broad.mit.edu	37	11	36516553	36516553	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:36516553G>A	ENST00000526995.1	-	5	897	c.651C>T	c.(649-651)taC>taT	p.Y217Y	TRAF6_ENST00000348124.5_Silent_p.Y217Y|TRAF6_ENST00000529150.1_5'UTR	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	217	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				TAGTATTGCAGTATTCACAGA	0.269000													27	28					0	0	1	0	0
SMAD4	4089	broad.mit.edu	37	18	48603092	48603092	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:48603092G>A	ENST00000342988.3	+	11	1931	c.1393G>A	c.(1393-1395)Gtg>Atg	p.V465M	SMAD4_ENST00000588745.1_Missense_Mutation_p.V369M|SMAD4_ENST00000398417.2_Missense_Mutation_p.V465M	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	465	MH2.|Poly-Ala.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(2)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GGCAGCAGCCGTGGCAGGAAA	0.463000													13	12					0	0	1	0	0
FZR1	51343	broad.mit.edu	37	19	3526341	3526341	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3526341G>A	ENST00000441788.2	+	5	580	c.344G>A	c.(343-345)cGc>cAc	p.R115H	FZR1_ENST00000395095.3_Missense_Mutation_p.R115H|FZR1_ENST00000313639.8_Missense_Mutation_p.R115H	NM_016263.3	NP_057347.2	Q9UM11	FZR_HUMAN	fizzy/cell division cycle 20 related 1 (Drosophila)	115					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			endometrium(1)|kidney(4)|liver(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTGAGGACCGCAGGCTGCAG	0.682000													3	5					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77671486	77671486	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:77671486C>T	ENST00000461745.1	+	23	4563	c.3663C>T	c.(3661-3663)gcC>gcT	p.A1221A	ROBO2_ENST00000332191.8_Silent_p.A1221A|ROBO2_ENST00000487694.3_Silent_p.A1237A	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1221					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ATGATGATGCCGACGACGAAG	0.498000													23	29					0	0	1	0	0
CDKL2	8999	broad.mit.edu	37	4	76523296	76523296	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:76523296A>G	ENST00000429927.2	-	8	1688	c.985T>C	c.(985-987)Tcc>Ccc	p.S329P	CDKL2_ENST00000307465.4_Missense_Mutation_p.S329P	NM_003948.3	NP_003939.1	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2 (CDC2-related kinase)	329					sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(2)|stomach(2)	22			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TCAACTAAGGAATCATCTTTT	0.264000													10	30					0	0	1	0	0
JMJD7-PLA2G4B	0	broad.mit.edu	37	15	42134140	42134140	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42134140G>A	ENST00000382448.4	+	13	1316	c.1307G>A	c.(1306-1308)cGc>cAc	p.R436H	PLA2G4B_ENST00000452633.1_Missense_Mutation_p.R205H|JMJD7-PLA2G4B_ENST00000342159.4_Missense_Mutation_p.R436H|JMJD7-PLA2G4B_ENST00000458483.1_Missense_Mutation_p.R205H	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		205	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						CTGAGTATTCGCCTGCAGGTA	0.657000													7	12					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63904748	63904748	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:63904748G>A	ENST00000443617.2	-	77	14189	c.14102C>T	c.(14101-14103)gCa>gTa	p.A4701V		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4701	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TTCTCGGACTGCAGCCACCTG	0.602000													13	25					0	0	1	0	0
PRH2	5555	broad.mit.edu	37	12	11083323	11083323	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:11083323C>T	ENST00000396400.3	+	3	201	c.163C>T	c.(163-165)Caa>Taa	p.Q55*	PRR4_ENST00000536668.1_Intron|PRH2_ENST00000381847.3_Nonsense_Mutation_p.Q55*	NM_001110213.1	NP_001103683.1	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 2	55						extracellular space	protein binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	13						GGGAGGACAGCAATCTCAACC	0.552000													9	48					0	0	1	0	0
FIGN	55137	broad.mit.edu	37	2	164467699	164467699	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:164467699G>A	ENST00000333129.3	-	3	957	c.643C>T	c.(643-645)Cat>Tat	p.H215Y	FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	215	Pro-rich.					nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						CCAGAGCTATGCAAAGGAGAC	0.527000													17	21					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88201757	88201757	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:88201757G>A	ENST00000357081.3	-	22	3166	c.3022C>T	c.(3022-3024)Cgt>Tgt	p.R1008C	AGTPBP1_ENST00000376109.3_Missense_Mutation_p.R1020C|AGTPBP1_ENST00000376083.3_Missense_Mutation_p.R968C|AGTPBP1_ENST00000337006.4_3'UTR|AGTPBP1_ENST00000432218.1_Intron			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1008					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						AAGGGTAAACGCTTCACTGCA	0.388000													4	88					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37185146	37185146	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:37185146G>A	ENST00000274258.7	-	25	4455	c.868C>T	c.(868-870)Cat>Tat	p.H290Y	C5orf42_ENST00000508244.1_Missense_Mutation_p.H1409Y|C5orf42_ENST00000425232.2_Missense_Mutation_p.H1409Y			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1409										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TGGATAGAATGCATGACAACA	0.368000													23	35					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43814556	43814556	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43814556G>A	ENST00000382031.1	+	5	1630	c.1599G>A	c.(1597-1599)acG>acA	p.T533T	MAP1A_ENST00000399453.1_Silent_p.T295T|MAP1A_ENST00000300231.5_Silent_p.T295T			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	295	9 X 3 AA repeats of K-K-[DE].					cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CTGTGGCCACGCAGAAGGACC	0.537000													16	20					0	0	1	0	0
NTSR2	23620	broad.mit.edu	37	2	11809657	11809657	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:11809657C>T	ENST00000306928.5	-	1	633	c.599G>A	c.(598-600)cGc>cAc	p.R200H		NM_012344.3	NP_036476.1	O95665	NTR2_HUMAN	neurotensin receptor 2	200					sensory perception	integral to plasma membrane				breast(1)|large_intestine(7)|lung(7)|prostate(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	GAGCGCGGTGCGGCTCACCAG	0.711000													5	9					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46830832	46830832	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:46830832C>T	ENST00000283296.7	-	15	2280	c.1990_splice	c.e15-1	p.G664_splice	GPR116_ENST00000545669.1_Splice_Site_p.G93_splice|GPR116_ENST00000265417.7_Splice_Site_p.G664_splice|GPR116_ENST00000456426.2_Splice_Site_p.G522_splice|GPR116_ENST00000362015.4_Splice_Site_p.G664_splice	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	664					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			TGATGTTTTCCCCTGTGTTGG	0.453000													24	35					0	0	1	0	0
MEIS1	4211	broad.mit.edu	37	2	66670093	66670093	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:66670093G>A	ENST00000488550.1	+	6	842	c.543G>A	c.(541-543)atG>atA	p.M181I	MEIS1_ENST00000495021.2_Missense_Mutation_p.M116I|MEIS1_ENST00000560281.2_Missense_Mutation_p.M181I|MEIS1_ENST00000444274.2_Missense_Mutation_p.M149I|MEIS1_ENST00000407092.2_Missense_Mutation_p.M181I|MEIS1_ENST00000398506.2_Missense_Mutation_p.M179I|MEIS1_ENST00000272369.9_Missense_Mutation_p.M181I			O00470	MEIS1_HUMAN	Meis homeobox 1	181							sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	24						AAGGGAAAATGCCTATCGATT	0.368000													46	69					0	0	1	0	0
WNT9A	7483	broad.mit.edu	37	1	228109686	228109686	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228109686C>T	ENST00000272164.5	-	4	641	c.631G>A	c.(631-633)Gtg>Atg	p.V211M	WNT9A_ENST00000497852.1_Intron	NM_003395.2	NP_003386.1	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family, member 9A	211					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Prostate(94;0.0405)				GTGGTCTCCACCCCAGCCTTG	0.662000													23	24					0	0	1	0	0
EHF	26298	broad.mit.edu	37	11	34680239	34680239	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:34680239G>T	ENST00000257831.3	+	8	888	c.767G>T	c.(766-768)aGc>aTc	p.S256I	EHF_ENST00000533754.1_Missense_Mutation_p.S256I|EHF_ENST00000530286.1_Missense_Mutation_p.S256I|EHF_ENST00000450654.2_Missense_Mutation_p.S233I|EHF_ENST00000531794.1_Missense_Mutation_p.S278I	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	256					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			AAGAACAACAGCAGCATGACC	0.448000													13	31					1.5842e-08	1.67426e-08	1	1	0
LIMK1	3984	broad.mit.edu	37	7	73511051	73511051	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:73511051C>T	ENST00000418310.1	+	3	444	c.342C>T	c.(340-342)tgC>tgT	p.C114C	LIMK1_ENST00000538333.3_Silent_p.C50C|LIMK1_ENST00000491052.1_3'UTR|LIMK1_ENST00000336180.2_Silent_p.C84C			P53667	LIMK1_HUMAN	LIM domain kinase 1	84	LIM zinc-binding 2.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				GCGAGTCCTGCCATGGGTGCT	0.592000													12	26					0	0	1	0	0
RPL6	6128	broad.mit.edu	37	12	112844588	112844588	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112844588G>T	ENST00000424576.2	-	4	628	c.443C>A	c.(442-444)aCc>aAc	p.T148N	RPL6_ENST00000202773.9_Missense_Mutation_p.T148N	NM_001024662.1	NP_001019833.1	Q02878	RL6_HUMAN	ribosomal protein L6	148					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			cervix(1)|large_intestine(6)|lung(3)	10						GATCAGAATGGTCCCGGGGGT	0.562000													14	17					1.5842e-08	1.67426e-08	1	1	0
MYOM3	127294	broad.mit.edu	37	1	24408513	24408513	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24408513G>T	ENST00000330966.7	-	18	2423	c.2261C>A	c.(2260-2262)cCc>cAc	p.P754H	MYOM3_ENST00000329601.7_Missense_Mutation_p.P753H|MYOM3_ENST00000374434.3_Missense_Mutation_p.P753H|RP11-293P20.4_ENST00000429191.1_RNA|MYOM3_ENST00000475306.1_5'UTR|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	753	Fibronectin type-III 4.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GGTGGGGATGGGCTGCTGATT	0.602000													7	6					0.00198382	0.0020125	1	1	0
ZFP90	146198	broad.mit.edu	37	16	68598186	68598186	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:68598186G>A	ENST00000570495.1	+	5	1788	c.1496G>A	c.(1495-1497)tGt>tAt	p.C499Y	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000563169.2_Missense_Mutation_p.C499Y|ZFP90_ENST00000398253.2_Missense_Mutation_p.C499Y			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	499					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		CCCTATCAATGTAATGTATGT	0.413000													27	54					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152774700	152774700	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152774700C>A	ENST00000495090.2	-	12	1757	c.1749G>T	c.(1747-1749)gaG>gaT	p.E583D	SYNE1_ENST00000367255.5_Intron|SYNE1_ENST00000367248.3_Intron|SYNE1_ENST00000367253.4_Intron|SYNE1_ENST00000448038.1_Intron|SYNE1_ENST00000413186.2_Intron|SYNE1_ENST00000341594.5_Intron|SYNE1_ENST00000423061.1_Intron|SYNE1_ENST00000265368.4_Intron			Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3592					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCACGGTGTCTCCGTCCTGT	0.483000										HNSCC(10;0.0054)			14	127					5.01169e-05	5.15048e-05	1	1	0
SLITRK1	114798	broad.mit.edu	37	13	84453636	84453636	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:84453636G>C	ENST00000377084.2	-	1	2892	c.2007C>G	c.(2005-2007)gaC>gaG	p.D669E		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	669						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AGTAGGAAGAGTCACAGACTG	0.537000													4	11					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47353711	47353711	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:47353711C>T	ENST00000545968.1	-	33	3780	c.3726G>A	c.(3724-3726)aaG>aaA	p.K1242K	MYBPC3_ENST00000256993.4_Silent_p.K1241K|MYBPC3_ENST00000399249.2_Silent_p.K1242K	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	1241	Ig-like C2-type 7.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		AGGGGCAGGGCTTTCTAATCT	0.597000													29	39					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	420840	420840	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:420840C>T	ENST00000332826.6	-	18	1595	c.1511G>A	c.(1510-1512)cGc>cAc	p.R504H		NM_001012302.2	NP_001012302.2	A1A5B4	ANO9_HUMAN	anoctamin 9	504						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						CCGCAGAGAGCGGCACTTGTG	0.741000													4	5					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105412499	105412499	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105412499C>T	ENST00000333244.5	-	7	9408	c.9289G>A	c.(9289-9291)Gtg>Atg	p.V3097M	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3097						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGGCCGTCACGTCCGTCTTC	0.622000													83	80					0	0	1	0	0
IDS	3423	broad.mit.edu	37	X	148585690	148585690	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:148585690C>T	ENST00000340855.6	-	2	446	c.237G>A	c.(235-237)gcG>gcA	p.A79A	IDS_ENST00000541269.1_Intron|IDS_ENST00000370441.4_Silent_p.A79A|IDS_ENST00000370443.4_Silent_p.A79A|AF011889.5_ENST00000422081.1_RNA|IDS_ENST00000428056.2_Silent_p.A79A	NM_000202.5|NM_001166550.1	NP_000193.1|NP_001160022.1	P22304	IDS_HUMAN	iduronate 2-sulfatase	79			A -> E (in MPS2; mild form).			lysosome	iduronate-2-sulfatase activity|metal ion binding			NS(1)|breast(3)|endometrium(5)|large_intestine(2)|lung(8)|prostate(1)	20	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GACATACCTGCGCAAAGGCAT	0.572000													4	3					0	0	1	0	0
INPP5J	27124	broad.mit.edu	37	22	31520898	31520898	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31520898C>T	ENST00000331075.5	+	2	222	c.173C>T	c.(172-174)gCt>gTt	p.A58V	INPP5J_ENST00000404390.3_Intron|INPP5J_ENST00000412277.2_5'UTR|INPP5J_ENST00000405300.1_Intron|INPP5J_ENST00000400294.2_Intron			Q15735	PI5PA_HUMAN	inositol polyphosphate-5-phosphatase J	58						cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	12						CCAAGGTTGGCTCTGGCACCT	0.577000													7	5					0	0	1	0	0
PSMG3	84262	broad.mit.edu	37	7	1608765	1608765	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:1608765C>T	ENST00000288607.2	-	1	864	c.211G>A	c.(211-213)Gat>Aat	p.D71N	PSMG3_ENST00000404674.3_Missense_Mutation_p.D71N|PSMG3_ENST00000252329.3_Missense_Mutation_p.D71N	NM_032302.3	NP_115678.1	Q9BT73	PSMG3_HUMAN	proteasome (prosome, macropain) assembly chaperone 3	71										lung(2)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.63e-15)		TTTACCTCATCCTGCCCCAGA	0.592000													21	33					0	0	1	0	0
LEMD1	93273	broad.mit.edu	37	1	205388421	205388421	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:205388421C>T	ENST00000367153.4	-	3	244	c.142G>A	c.(142-144)Gca>Aca	p.A48T	LEMD1_ENST00000367149.3_Intron|LEMD1_ENST00000367151.2_Intron|LEMD1_ENST00000476884.1_Intron|LEMD1_ENST00000391936.2_Missense_Mutation_p.A48T|LEMD1_ENST00000367154.1_Missense_Mutation_p.A48T|LEMD1_ENST00000367152.1_Intron	NM_001199050.1	NP_001185979.1	Q68G75	LEMD1_HUMAN	LEM domain containing 1	48						integral to membrane|nuclear envelope				breast(1)|lung(2)	3	Breast(84;0.247)		BRCA - Breast invasive adenocarcinoma(75;0.0938)			ACAGGTGGTGCACAGGGAGGT	0.453000													46	35					0	0	1	0	0
KRT36	8689	broad.mit.edu	37	17	39644629	39644629	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39644629G>A	ENST00000393986.2	-	4	627	c.415C>T	c.(415-417)Cgg>Tgg	p.R139W	KRT36_ENST00000328119.6_Missense_Mutation_p.R189W			O76013	KRT36_HUMAN	keratin 36	189	Linker 1.|Rod.					intermediate filament	protein binding|structural constituent of epidermis			breast(2)|cervix(1)|kidney(2)|large_intestine(3)|lung(8)|skin(1)	17		Breast(137;0.000286)				ACTAGCTGCCGCAGAGACAGC	0.597000													21	28					0	0	1	0	0
LYSMD4	145748	broad.mit.edu	37	15	100269761	100269761	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:100269761T>G	ENST00000545021.1	-	4	894	c.80A>C	c.(79-81)gAc>gCc	p.D27A	LYSMD4_ENST00000604213.1_Intron|LYSMD4_ENST00000332728.4_Missense_Mutation_p.D153A|LYSMD4_ENST00000344791.2_Missense_Mutation_p.D154A|LYSMD4_ENST00000409796.1_Missense_Mutation_p.D153A			Q5XG99	LYSM4_HUMAN	LysM, putative peptidoglycan-binding, domain containing 4	153					cell wall macromolecule catabolic process	integral to membrane				breast(1)|cervix(1)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)	10	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00162)|LUSC - Lung squamous cell carcinoma(107;0.17)|Lung(145;0.208)			GCCTGCTCTGTCTGCCTCTGG	0.562000													49	52					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155313529	155313529	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155313529G>A	ENST00000368346.3	-	23	8640	c.8001C>T	c.(7999-8001)gaC>gaT	p.D2667D	ASH1L_ENST00000392403.3_Silent_p.D2662D			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	2667	BAH.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GATACACACAGTCACCTAGGA	0.448000													16	26					0	0	1	0	0
NRIP2	83714	broad.mit.edu	37	12	2936421	2936421	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:2936421C>T	ENST00000337508.4	-	6	838	c.798G>A	c.(796-798)ccG>ccA	p.P266P	ITFG2_ENST00000542548.1_Intron	NM_031474.2	NP_113662.1	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	266					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GCTCTGAGAACGGGGCTTTCA	0.612000													7	12					0	0	1	0	0
CDCA5	113130	broad.mit.edu	37	11	64847156	64847156	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64847156G>T	ENST00000275517.3	-	5	519	c.347C>A	c.(346-348)cCt>cAt	p.P116H	CDCA5_ENST00000404147.3_Missense_Mutation_p.P116H	NM_080668.3	NP_542399.1	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	116					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding			large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GTTCGGCACAGGAGTGCTGGT	0.567000													7	8					0.000274275	0.000279654	1	1	0
USP34	9736	broad.mit.edu	37	2	61463362	61463362	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:61463362C>T	ENST00000398571.2	-	55	6928	c.6852G>A	c.(6850-6852)tgG>tgA	p.W2284*		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	2284					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.W2284C(1)		autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TACACAATTGCCACATAAATC	0.269000													21	45					0	0	1	0	0
PDE3B	5140	broad.mit.edu	37	11	14665692	14665692	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:14665692C>T	ENST00000282096.4	+	1	424	c.71C>T	c.(70-72)cCc>cTc	p.P24L	PDE3B_ENST00000455098.2_Missense_Mutation_p.P24L	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	24					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GGCTCGCCCCCCGAGAGTCTG	0.697000													5	4					0	0	1	0	0
VARS	7407	broad.mit.edu	37	6	31759732	31759732	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31759732C>T	ENST00000375663.3	-	7	1328	c.888G>A	c.(886-888)atG>atA	p.M296I	VARS_ENST00000444930.2_Start_Codon_SNP_p.M1I	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	296					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	AGGAGTCGGGCATGGGGCCAC	0.627000													4	7					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189940164	189940164	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:189940164C>A	ENST00000374866.3	-	17	1334		c.e17-1			NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2						axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CTCGTTGTCCCTAATTAAGAG	0.299000													15	55					3.41278e-10	3.64137e-10	1	1	0
TECTA	7007	broad.mit.edu	37	11	120996472	120996472	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:120996472C>T	ENST00000392793.1	+	8	1936	c.1665C>T	c.(1663-1665)tgC>tgT	p.C555C	TECTA_ENST00000264037.2_Silent_p.C555C			O75443	TECTA_HUMAN	tectorin alpha	555					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ATGACCTGTGCAGTGTGAGGG	0.577000													32	45					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139216755	139216755	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:139216755C>A	ENST00000274710.3	+	11	1802	c.1597C>A	c.(1597-1599)Ccc>Acc	p.P533T		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	533	PH.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCCCAGCGCCCCGTGGGAG	0.592000													25	50					1.2476e-16	1.37101e-16	1	1	0
GLT8D2	83468	broad.mit.edu	37	12	104390558	104390558	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104390558G>A	ENST00000360814.4	-	8	960	c.555C>T	c.(553-555)tgC>tgT	p.C185C	GLT8D2_ENST00000548660.1_Silent_p.C185C|GLT8D2_ENST00000546436.1_Silent_p.C185C	NM_031302.3	NP_112592.1	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	185						integral to membrane	transferase activity, transferring glycosyl groups			kidney(3)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						AGGGCAAATCGCAGTCATCTG	0.502000													25	21					0	0	1	0	0
WBP2NL	164684	broad.mit.edu	37	22	42423111	42423111	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:42423111G>A	ENST00000328823.9	+	6	887	c.856G>A	c.(856-858)Gaa>Aaa	p.E286K	WBP2NL_ENST00000543212.1_Missense_Mutation_p.E212K	NM_152613.2	NP_689826.2	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	286					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			breast(2)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)	14						CAGGCCTCAGGAATCTACAGC	0.562000													34	54					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142231719	142231719	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:142231719G>A	ENST00000519067.1	-	2	537	c.234C>T	c.(232-234)ggC>ggT	p.G78G	SLC45A4_ENST00000433583.2_Silent_p.G71G|SLC45A4_ENST00000024061.3_Silent_p.G78G|SLC45A4_ENST00000517878.1_Silent_p.G129G			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	129					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CAAAGAGGACGCCAACGCAGA	0.622000													27	37					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140265510	140265510	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:140265510G>A	ENST00000458420.3	+	10	1851	c.1661G>A	c.(1660-1662)gGc>gAc	p.G554D		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	554					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GAAAGCCTTGGCCAAGGAATA	0.547000										HNSCC(16;0.037)			9	12					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132991264	132991264	+	Silent	SNP	C	C	T	rs141932899	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:132991264C>T	ENST00000254624.5	+	13	1722	c.1497C>T	c.(1495-1497)atC>atT	p.I499I	EFR3A_ENST00000334503.4_Silent_p.I499I|EFR3A_ENST00000519656.1_Silent_p.I463I	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	499						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TTCGAGGGATCAGGTAATGTG	0.358000													19	29					0	0	1	0	0
LRRTM2	26045	broad.mit.edu	37	5	138209844	138209844	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:138209844G>A	ENST00000274711.6	-	2	784	c.406C>T	c.(406-408)Caa>Taa	p.Q136*	CTNNA1_ENST00000518825.1_Intron|CTNNA1_ENST00000520400.1_Intron|LRRTM2_ENST00000521094.2_Intron|LRRTM2_ENST00000518785.1_Intron|LRRTM2_ENST00000523537.1_Intron|CTNNA1_ENST00000355078.5_Intron|CTNNA1_ENST00000302763.7_Intron	NM_015564.2	NP_056379.1	O43300	LRRT2_HUMAN	leucine rich repeat transmembrane neuronal 2	136						cell junction|integral to membrane|postsynaptic membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(1)|urinary_tract(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TCCAAATTTTGCAGGTTAATC	0.388000													3	9					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901789	51901789	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:51901789G>A	ENST00000268919.4	+	1	1551	c.1395G>A	c.(1393-1395)caG>caA	p.Q465Q		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	465	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GGAAAAGGCAGCTGGAAGGGG	0.493000													13	17					0	0	1	0	0
INSR	0	broad.mit.edu	37	19	7125510	7125510	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7125510G>A	ENST00000341500.5	-	16	3045	c.3006C>T	c.(3004-3006)gaC>gaT	p.D1002D	INSR_ENST00000302850.5_Silent_p.D1014D	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1014					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTCCCACTCGTCCGGCACGT	0.567000													22	22					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95481033	95481033	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95481033C>T	ENST00000356884.6	-	5	1961	c.1894G>A	c.(1894-1896)Gct>Act	p.A632T	BICD2_ENST00000375512.3_Missense_Mutation_p.A632T	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	632					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						CGGATGATAGCGATCAGGTTG	0.652000													26	46					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73738694	73738694	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73738694C>T	ENST00000200181.3	+	25	3001	c.2814C>T	c.(2812-2814)ggC>ggT	p.G938G	ITGB4_ENST00000579662.1_Silent_p.G938G|ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000450894.3_Silent_p.G938G|ITGB4_ENST00000339591.3_Silent_p.G938G|ITGB4_ENST00000449880.2_Silent_p.G938G	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	938					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCAGGAGGGCGTGGAGCTGG	0.677000													13	20					0	0	1	0	0
C12orf5	57103	broad.mit.edu	37	12	4459010	4459010	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:4459010G>T	ENST00000179259.4	+	4	285	c.218G>T	c.(217-219)aGc>aTc	p.S73I	C12orf5_ENST00000537251.1_3'UTR	NM_020375.2	NP_065108.1	Q9NQ88	TIGAR_HUMAN	chromosome 12 open reading frame 5	73						intracellular	fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(1)|large_intestine(1)|lung(5)|skin(3)	10			all cancers(3;1.15e-07)|Colorectal(7;0.00165)|OV - Ovarian serous cystadenocarcinoma(31;0.00596)|COAD - Colon adenocarcinoma(12;0.0229)|GBM - Glioblastoma multiforme(3;0.0266)|STAD - Stomach adenocarcinoma(119;0.206)			TTGGAGAGAAGCAAATTTTGC	0.338000													9	38					0.0581538	0.0584448	1	1	0
CSF2RB	1439	broad.mit.edu	37	22	37322029	37322029	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37322029G>A	ENST00000262825.5	+	4	418	c.200_splice	c.e4-1	p.E67_splice	CSF2RB_ENST00000403662.3_Splice_Site_p.E67_splice|CSF2RB_ENST00000406230.1_Splice_Site_p.E67_splice|CSF2RB_ENST00000536485.1_Splice_Site_p.R8_splice	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	67					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity	p.E67E(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CTCCCAACAGGGACCTCCTGG	0.597000													6	11					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108004005	108004005	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:108004005C>T	ENST00000280758.5	+	5	2210	c.1682C>T	c.(1681-1683)gCg>gTg	p.A561V	BTBD11_ENST00000357167.4_Missense_Mutation_p.A98V|BTBD11_ENST00000420571.2_Missense_Mutation_p.A561V|RP11-128P10.1_ENST00000548473.1_RNA|BTBD11_ENST00000490090.2_Missense_Mutation_p.A561V	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	561						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AAGCTGGATGCGGTGGCCATC	0.582000											OREG0022090	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	58					0	0	1	0	0
PCDHGB1	0	broad.mit.edu	37	5	140731726	140731726	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140731726G>A	ENST00000523390.1	+	1	1899	c.1899G>A	c.(1897-1899)gcG>gcA	p.A633A	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGGGACGCGGCCCGCCAGC	0.697000													14	21					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176707813	176707813	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176707813G>A	ENST00000439151.2	+	18	5915	c.5870G>A	c.(5869-5871)cGg>cAg	p.R1957Q	NSD1_ENST00000361032.4_Missense_Mutation_p.R1854Q|NSD1_ENST00000354179.4_Missense_Mutation_p.R1688Q|NSD1_ENST00000347982.4_Missense_Mutation_p.R1688Q	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1957	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TGGGGTCTACGGACAAAAACA	0.418000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			25	29					0	0	1	0	0
CCDC97	90324	broad.mit.edu	37	19	41828534	41828534	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41828534G>A	ENST00000269967.3	+	5	1068	c.946G>A	c.(946-948)Gac>Aac	p.D316N		NM_052848.1	NP_443080.1	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	316										biliary_tract(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	17						CGACAACCTCGACATCGTGGC	0.612000													10	48					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70948980	70948980	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:70948980C>A	ENST00000357250.6	-	33	2247	c.2089G>T	c.(2089-2091)Gga>Tga	p.G697*	RP1-149L1.1_ENST00000522264.1_RNA|COL9A1_ENST00000370499.4_Nonsense_Mutation_p.G454*|COL9A1_ENST00000320755.7_Nonsense_Mutation_p.G454*|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	697	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						CCAGGTAATCCTATATCTCCC	0.259000													7	82					5.4927e-09	5.81457e-09	1	1	0
ARAP1	116985	broad.mit.edu	37	11	72406494	72406494	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:72406494C>T	ENST00000359373.5	-	26	4365	c.3514G>A	c.(3514-3516)Ggt>Agt	p.G1172S	ARAP1_ENST00000426523.1_Missense_Mutation_p.G927S|ARAP1_ENST00000429686.1_Missense_Mutation_p.G866S|ARAP1_ENST00000393605.3_Missense_Mutation_p.G932S|ARAP1_ENST00000334211.8_Missense_Mutation_p.G927S|ARAP1_ENST00000393609.3_Missense_Mutation_p.G1172S|ARAP1_ENST00000495878.1_5'UTR|ARAP1_ENST00000455638.2_Missense_Mutation_p.G1172S			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	1172	Ras-associating.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						ATGAAGTCACCGGCATGCTGC	0.592000													23	32					0	0	1	0	0
P4HA1	5033	broad.mit.edu	37	10	74806744	74806744	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:74806744C>T	ENST00000412021.2	-	9	1349	c.1016G>A	c.(1015-1017)cGc>cAc	p.R339H	P4HA1_ENST00000263556.3_Missense_Mutation_p.R339H|P4HA1_ENST00000394890.2_Missense_Mutation_p.R339H|P4HA1_ENST00000440381.1_Missense_Mutation_p.R339H|P4HA1_ENST00000307116.2_Missense_Mutation_p.R339H|P4HA1_ENST00000373008.2_Missense_Mutation_p.R339H	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I	339						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ATCATGGAAGCGAATAATACG	0.368000													21	37					0	0	1	0	0
SLC12A4	6560	broad.mit.edu	37	16	67980408	67980408	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67980408G>A	ENST00000422611.2	-	17	2415	c.2376C>T	c.(2374-2376)tcC>tcT	p.S792S	SLC12A4_ENST00000537830.2_Silent_p.S784S|SLC12A4_ENST00000576616.1_Silent_p.S790S|SLC12A4_ENST00000316341.3_Silent_p.S790S|SLC12A4_ENST00000572037.1_Silent_p.S742S|SLC12A4_ENST00000338335.3_Intron|SLC12A4_ENST00000541864.2_Silent_p.S759S	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	790					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCAGCACCACGGAGTTATGCC	0.677000													6	25					0	0	1	0	0
PKN2	5586	broad.mit.edu	37	1	89250335	89250335	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:89250335T>C	ENST00000370521.3	+	7	1358	c.999T>C	c.(997-999)gtT>gtC	p.V333V	PKN2_ENST00000544045.1_Silent_p.V7V|PKN2_ENST00000316005.7_Silent_p.V333V|PKN2_ENST00000370505.3_Silent_p.V176V|PKN2_ENST00000370513.5_Silent_p.V333V	NM_006256.2	NP_006247.1	Q16513	PKN2_HUMAN	protein kinase N2	333	C2.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(1)	33		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		CTTTGGAAGTTCGTCTTATGG	0.398000													24	30					0	0	1	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161167913	161167913	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161167913T>C	ENST00000367996.4	-	1	933	c.505A>G	c.(505-507)Acc>Gcc	p.T169A	ADAMTS4_ENST00000367995.3_Missense_Mutation_p.T169A	NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	169					proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GAGTTAGGGGTGCCTCCCTCC	0.627000													15	19					0	0	1	0	0
KDELC2	143888	broad.mit.edu	37	11	108350118	108350118	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:108350118T>C	ENST00000434945.2	-	5	1337	c.1035A>G	c.(1033-1035)gaA>gaG	p.E345E	KDELC2_ENST00000532730.1_Intron|KDELC2_ENST00000375648.1_Silent_p.E345E|KDELC2_ENST00000323468.5_Silent_p.E401E			Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2	401						endoplasmic reticulum lumen				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		TGTAGAAATGTTCATAATATG	0.403000													3	59					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466968	56466968	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56466968C>T	ENST00000291971.3	+	3	1615	c.1544C>T	c.(1543-1545)gCg>gTg	p.A515V	NLRP8_ENST00000590542.1_Missense_Mutation_p.A515V	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	515	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAATTTTTTGCGGCCTTGTTT	0.468000													54	84					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577923	9577923	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9577923G>A	ENST00000301480.4	-	10	1913	c.1700C>T	c.(1699-1701)gCt>gTt	p.A567V		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	567					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TTTCTCTCCAGCGTGTGTTCG	0.408000													15	83					0	0	1	0	0
KIAA0141	9812	broad.mit.edu	37	5	141316895	141316895	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:141316895C>T	ENST00000432126.2	+	11	1416	c.1282C>T	c.(1282-1284)Cga>Tga	p.R428*	KIAA0141_ENST00000194118.4_Nonsense_Mutation_p.R428*	NM_001142603.1|NM_014773.3	NP_001136075.1|NP_055588.3	Q14154	DELE_HUMAN	KIAA0141	428					apoptosis|regulation of caspase activity	mitochondrion	protein binding			endometrium(3)|large_intestine(4)|lung(5)|skin(1)|urinary_tract(3)	16		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGAGGCTGCGAGCCCTCTT	0.557000													27	40					0	0	1	0	0
CBX2	84733	broad.mit.edu	37	17	77758430	77758430	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:77758430C>T	ENST00000310942.4	+	5	1292	c.1188C>T	c.(1186-1188)ctC>ctT	p.L396L		NM_005189.2	NP_005180.1	Q14781	CBX2_HUMAN	chromobox homolog 2	396					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGAGTGGCCTCATTGGGGCCA	0.682000													6	5					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390709	8390709	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:8390709G>A	ENST00000471889.1	+	5	1541	c.1156G>A	c.(1156-1158)Gac>Aac	p.D386N	SLC45A1_ENST00000481265.1_3'UTR|SLC45A1_ENST00000377479.2_Missense_Mutation_p.D420N|SLC45A1_ENST00000289877.8_Missense_Mutation_p.D386N			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	386					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCGGCCACGACAGCTACCT	0.662000													9	15					0	0	1	0	0
ANKS6	203286	broad.mit.edu	37	9	101533322	101533322	+	Missense_Mutation	SNP	C	C	T	rs138782444	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:101533322C>T	ENST00000353234.4	-	10	1875	c.1828G>A	c.(1828-1830)Gtc>Atc	p.V610I	ANKS6_ENST00000375018.1_Missense_Mutation_p.V610I|ANKS6_ENST00000540940.1_Missense_Mutation_p.V415I|ANKS6_ENST00000375019.2_Missense_Mutation_p.V309I			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	610										endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				ACAGGCCTGACGGGTGTCTAC	0.577000													3	15					0	0	1	0	0
EEF2K	29904	broad.mit.edu	37	16	22268671	22268671	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:22268671C>T	ENST00000263026.5	+	8	1340	c.866C>T	c.(865-867)aCg>aTg	p.T289M		NM_013302.3	NP_037434.1	O00418	EF2K_HUMAN	eukaryotic elongation factor-2 kinase	289	Alpha-type protein kinase.				insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(8)|large_intestine(2)|lung(13)|ovary(1)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(48;0.0223)		CAGATCCACACGGAGACGGGC	0.547000													10	35					0	0	1	0	0
ST6GALNAC4	27090	broad.mit.edu	37	9	130674860	130674860	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130674860C>T	ENST00000335791.5	-	4	573	c.298G>A	c.(298-300)Gtg>Atg	p.V100M	ST6GALNAC4_ENST00000343609.2_Missense_Mutation_p.V16M|ST6GALNAC4_ENST00000495983.1_5'UTR	NM_175039.3	NP_778204.1	Q9H4F1	SIA7D_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	100					glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7						ATGCGGAACACGCACTCGGCA	0.682000													12	12					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31294080	31294080	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:31294080G>A	ENST00000542188.1	-	27	5187	c.4874C>T	c.(4873-4875)aCa>aTa	p.T1625I	TRPM1_ENST00000256552.6_Missense_Mutation_p.T1608I|TRPM1_ENST00000397795.2_Missense_Mutation_p.T1586I	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1586					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTCTTCTGCTGTCATTCCAGA	0.363000													15	34					0	0	1	0	0
LRRC39	127495	broad.mit.edu	37	1	100621788	100621788	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:100621788G>A	ENST00000370138.1	-	7	797	c.599C>T	c.(598-600)gCc>gTc	p.A200V	LRRC39_ENST00000370137.1_Missense_Mutation_p.A200V|LRRC39_ENST00000342895.3_Missense_Mutation_p.A200V	NM_001256385.1	NP_001243314.1	Q96DD0	LRC39_HUMAN	leucine rich repeat containing 39	200										endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	13		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0826)|all cancers(265;0.135)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		CCACTCAAGGGCAGGCATGTT	0.388000													15	30					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80433528	80433528	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:80433528C>T	ENST00000265361.3	-	8	1256	c.695G>A	c.(694-696)gGt>gAt	p.G232D	SEMA3C_ENST00000544525.1_Missense_Mutation_p.G250D|SEMA3C_ENST00000536800.1_Missense_Mutation_p.G84D|SEMA3C_ENST00000419255.2_Missense_Mutation_p.G232D	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	232	Sema.				immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TGGATCAGTACCATCTGGGAT	0.358000													23	30					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128485188	128485188	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128485188C>A	ENST00000325888.8	+	21	3930	c.3669C>A	c.(3667-3669)acC>acA	p.T1223T	FLNC_ENST00000346177.6_Silent_p.T1223T	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1223					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TCCCTGGCACCTACACCATTA	0.597000													7	21					0.000274275	0.000279654	1	1	0
IGHV1-18	0	broad.mit.edu	37	14	106641947	106641947	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:106641947G>A	ENST00000390605.2	-	0	105																											TGGGGAGTCCGTTACCTGTTG	0.572000													6	35					0	0	1	0	0
PLEKHH3	79990	broad.mit.edu	37	17	40825731	40825731	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40825731C>T	ENST00000293349.6	-	4	850	c.420G>A	c.(418-420)cgG>cgA	p.R140R	PLEKHH3_ENST00000412503.1_Silent_p.R140R|PLEKHH3_ENST00000591022.1_Silent_p.R140R|PLEKHH3_ENST00000456950.2_5'UTR			Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 3	140	PH.				signal transduction	cytoskeleton				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|skin(2)	13		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		TCCCGAGACGCCGCGCCCCTT	0.701000													7	16					0	0	1	0	0
KLK9	284366	broad.mit.edu	37	19	51509868	51509868	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:51509868G>A	ENST00000376832.4	-	3	345	c.312C>T	c.(310-312)agC>agT	p.S104S	CTB-147C22.9_ENST00000594512.1_RNA|KLK9_ENST00000594211.1_Silent_p.S104S|KLK9_ENST00000250366.6_Silent_p.S104S	NM_012315.1	NP_036447.1	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9	104	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		GGTCATTGGCGCTGAGGTCCT	0.602000													14	24					0	0	1	0	0
PDGFA	0	broad.mit.edu	37	7	540110	540110	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:540110G>A	ENST00000354513.5	-	6	999	c.607C>T	c.(607-609)Cgg>Tgg	p.R203W	PDGFA_ENST00000402802.3_Intron	NM_002607.5	NP_002598.4	P04085	PDGFA_HUMAN	platelet-derived growth factor alpha polypeptide	203					actin cytoskeleton organization|angiogenesis|cell projection assembly|embryo development|hair follicle development|lung alveolus development|negative chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|organ morphogenesis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of DNA replication|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of MAP kinase activity|positive regulation of mesenchymal cell proliferation|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein kinase B signaling cascade|regulation of actin cytoskeleton organization|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|regulation of peptidyl-tyrosine phosphorylation|regulation of smooth muscle cell migration|skin development	cell surface|endoplasmic reticulum lumen|extracellular space|Golgi membrane|microvillus|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|Epithelial(4;1.1e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.7e-17)|all cancers(6;4.89e-15)		TTTCTTTTCCGTTTTTTACCT	0.547000													12	30					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47286659	47286659	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:47286659G>A	ENST00000311191.6	+	15	1810		c.e15-1		LRCH1_ENST00000389798.3_Splice_Site|LRCH1_ENST00000389797.3_Splice_Site	NM_001164213.1	NP_001157685.1	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		CAACACCACAGATTAGAGAGA	0.408000													43	59					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75866131	75866131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:75866131C>T	ENST00000322507.8	-	15	3401	c.3092G>A	c.(3091-3093)cGc>cAc	p.R1031H	COL12A1_ENST00000483888.2_Missense_Mutation_p.R1031H|COL12A1_ENST00000416123.2_Missense_Mutation_p.R1031H|COL12A1_ENST00000345356.6_Intron	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1031	Fibronectin type-III 7.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CCCATGAGGGCGATAGACAAC	0.473000													11	41					0	0	1	0	0
PDDC1	347862	broad.mit.edu	37	11	771069	771069	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:771069G>A	ENST00000319863.8	-	7	601	c.580C>T	c.(580-582)Cgc>Tgc	p.R194C	PDDC1_ENST00000529966.1_5'UTR|PDDC1_ENST00000524550.1_Missense_Mutation_p.R158C|PDDC1_ENST00000397472.2_Intron|PDDC1_ENST00000442059.2_Missense_Mutation_p.R144C|PDDC1_ENST00000526325.1_Intron	NM_182612.2	NP_872418.1	Q8NB37	PDDC1_HUMAN	Parkinson disease 7 domain containing 1	194						extracellular region				kidney(1)|lung(3)|urinary_tract(1)	5		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;3.66e-26)|Epithelial(43;2.43e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-19)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACCAGGTGGCGGTCCAGCACG	0.652000													8	3					0	0	1	0	0
S100A3	6274	broad.mit.edu	37	1	153520234	153520234	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:153520234C>T	ENST00000368713.3	-	3	426	c.230G>A	c.(229-231)cGc>cAc	p.R77H	S100A4_ENST00000368714.1_Intron|S100A3_ENST00000368712.1_Missense_Mutation_p.R77H	NM_002960.1	NP_002951.1	P33764	S10A3_HUMAN	S100 calcium binding protein A3	77	EF-hand 2.						calcium ion binding|protein binding			breast(1)|liver(1)|lung(1)	3	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGCAAGTGAGCGCACATACTC	0.562000													29	65					0	0	1	0	0
ECM2	1842	broad.mit.edu	37	9	95280145	95280145	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95280145T>C	ENST00000344604.5	-	3	454	c.305A>G	c.(304-306)cAc>cGc	p.H102R	ECM2_ENST00000375540.1_Missense_Mutation_p.H102R|ECM2_ENST00000444490.2_Missense_Mutation_p.H102R|CENPP_ENST00000375587.3_Intron	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	102	VWFC.				cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						TACCAAACAGTGTCCCTTCTT	0.403000													13	17					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104224075	104224075	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:104224075C>T	ENST00000202556.9	-	5	650	c.368G>A	c.(367-369)cGt>cAt	p.R123H		NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	123					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				AAGTTCAACACGTGGATTCCC	0.398000													38	51					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100373052	100373052	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100373052G>A	ENST00000542585.1	+	0	6027				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GTGAAAGTGTGCCACCCCGCC	0.552000													15	15					0	0	1	0	0
LYZL6	57151	broad.mit.edu	37	17	34266305	34266305	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:34266305G>A	ENST00000585556.1	-	2	390	c.56C>T	c.(55-57)gCc>gTc	p.A19V	LYZL6_ENST00000394523.3_Missense_Mutation_p.A19V|LYZL6_ENST00000293274.4_Missense_Mutation_p.A19V			O75951	LYZL6_HUMAN	lysozyme-like 6	19					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			breast(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	12				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GATGAGGCTGGCCTGATTTAG	0.562000													31	48					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33874706	33874706	+	Missense_Mutation	SNP	G	G	A	rs141772980		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:33874706G>A	ENST00000374408.3	-	4	1972	c.1876C>T	c.(1876-1878)Cgg>Tgg	p.R626W		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	626								p.R626W(1)		central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GTCTGCCGCCGCTCATCTGGT	0.627000													13	16					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683688	100683688	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100683688G>A	ENST00000306151.4	+	3	9055	c.8991G>A	c.(8989-8991)atG>atA	p.M2997I		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2997	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAGCACCATGCCGGTGGCCA	0.502000													113	134					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50404460	50404460	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50404460G>A	ENST00000435965.1	-	29	2676	c.2503C>T	c.(2503-2505)Cgc>Tgc	p.R835C	CACNA2D2_ENST00000360963.3_Missense_Mutation_p.R759C|XXcos-LUCA11.4_ENST00000607121.1_RNA|CACNA2D2_ENST00000395083.1_Missense_Mutation_p.R828C|XXcos-LUCA11.4_ENST00000607583.1_RNA|XXcos-LUCA11.5_ENST00000606589.1_Intron|CACNA2D2_ENST00000423994.2_Missense_Mutation_p.R835C|XXcos-LUCA11.4_ENST00000606665.1_RNA|XXcos-LUCA11.4_ENST00000607088.1_RNA|CACNA2D2_ENST00000479441.1_Missense_Mutation_p.R835C|CACNA2D2_ENST00000429770.1_Missense_Mutation_p.R828C|CACNA2D2_ENST00000266039.3_Missense_Mutation_p.R828C|CACNA2D2_ENST00000424201.2_Missense_Mutation_p.R828C|XXcos-LUCA11.4_ENST00000606259.1_RNA			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	835					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	CTCAGTGTGCGCCTGCCTAGG	0.607000													11	19					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236900481	236900481	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:236900481G>A	ENST00000546208.1	+	3	210		c.e3+1		ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000366578.4_Silent_p.R281R|ACTN2_ENST00000542672.1_Silent_p.R281R			P35609	ACTN2_HUMAN	actinin, alpha 2						focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			AGAATGAGAGGCTGATGGAAG	0.507000													13	22					0	0	1	0	0
ST3GAL3	6487	broad.mit.edu	37	1	44201956	44201956	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:44201956G>A	ENST00000262915.3	+	2	200	c.23G>A	c.(22-24)cGc>cAc	p.R8H	ST3GAL3_ENST00000372374.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372369.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000361392.4_Missense_Mutation_p.R8H|ST3GAL3_ENST00000531451.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000531816.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000528371.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372375.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000545417.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000361812.4_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372372.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372362.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372377.4_Missense_Mutation_p.R8H|ST3GAL3_ENST00000347631.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000335430.6_Missense_Mutation_p.R8H|ST3GAL3_ENST00000361746.4_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372366.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000330208.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372368.2_Missense_Mutation_p.R8H|ST3GAL3_ENST00000361400.4_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372365.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000351035.3_Missense_Mutation_p.R8H|ST3GAL3_ENST00000353126.3_Missense_Mutation_p.R8H|ST3GAL3_ENST00000332628.6_Missense_Mutation_p.R8H|ST3GAL3_ENST00000372367.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000531993.1_Missense_Mutation_p.R8H|ST3GAL3_ENST00000533933.1_Missense_Mutation_p.R8H	NM_174963.3	NP_777623.2	Q11203	SIAT6_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	8					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(3)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				GTATTTGTGCGCAATCTGCTG	0.413000													11	159					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32138032	32138032	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:32138032C>T	ENST00000312561.4	+	4	4557	c.4143C>T	c.(4141-4143)aaC>aaT	p.N1381N	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		ACCAAGGGAACGTATTAGATA	0.343000													5	42					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56641862	56641862	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56641862G>A	ENST00000267116.7	-	18	2044	c.1923C>T	c.(1921-1923)ggC>ggT	p.G641G		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	641							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						GGGCAGAGGCGCCGTGGGCTG	0.627000													13	21					0	0	1	0	0
GNL2	29889	broad.mit.edu	37	1	38048477	38048477	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:38048477G>A	ENST00000373062.3	-	7	795	c.697C>T	c.(697-699)Cgt>Tgt	p.R233C		NM_013285.2	NP_037417.1	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2 (nucleolar)	233					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	30		Myeloproliferative disorder(586;0.0393)				TGAGGGGAACGAGTACCCATT	0.393000													23	36					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108432670	108432670	+	Missense_Mutation	SNP	G	G	A	rs143914023		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:108432670G>A	ENST00000263054.6	-	15	2021	c.2014C>T	c.(2014-2016)Cgg>Tgg	p.R672W	SORCS1_ENST00000344440.6_Missense_Mutation_p.R672W|SORCS1_ENST00000369698.1_Missense_Mutation_p.R207W	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	672						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCGGCACACCGTCTATCAAAA	0.488000													9	31					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2024280	2024280	+	Missense_Mutation	SNP	G	G	A	rs117189614	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:2024280G>A	ENST00000262113.4	+	11	1321	c.1180G>A	c.(1180-1182)Gcc>Acc	p.A394T	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	394	Fibronectin type-III 1.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GTGCCACGACGCCAACCGGGA	0.597000													7	13					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25486986	25486986	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:25486986G>A	ENST00000381884.4	-	2	363	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	CENPJ_ENST00000545981.1_Missense_Mutation_p.H60Y	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	60					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		TCAGAAAAATGTGTGCCTTTA	0.393000													29	55					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751146	19751146	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:19751146T>A	ENST00000400113.3	-	4	1081	c.977A>T	c.(976-978)aAa>aTa	p.K326I		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	326					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GTTGACATCTTTCGGGACCAC	0.542000													18	71					0	0	1	0	0
DTYMK	1841	broad.mit.edu	37	2	242625237	242625237	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:242625237G>A	ENST00000305784.2	-	2	393	c.186C>T	c.(184-186)gaC>gaT	p.D62D	DTYMK_ENST00000493095.1_5'UTR	NM_001165031.1|NM_012145.3	NP_001158503.1|NP_036277.2	P23919	KTHY_HUMAN	deoxythymidylate kinase (thymidylate kinase)	62					cell cycle|cell proliferation|nucleobase, nucleoside and nucleotide interconversion	cytosol	ATP binding|nucleoside phosphate kinase activity|thymidylate kinase activity			NS(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.6e-33)|all cancers(36;3.57e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.23e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		GATCCTCCACGTCACTTTTCT	0.438000													80	138					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47424426	47424426	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47424426C>T	ENST00000404338.3	+	1	2494	c.2494C>T	c.(2494-2496)Cgg>Tgg	p.R832W		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	832					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										GCACAAGAAGCGGATTGAACT	0.423000													30	56					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8613157	8613157	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8613157G>A	ENST00000338257.8	-	11	1413	c.1146C>T	c.(1144-1146)atC>atT	p.I382I		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	382	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CCAGCACACCGATGCTGTACT	0.612000													17	19					0	0	1	0	0
KLHL7	55975	broad.mit.edu	37	7	23205409	23205409	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:23205409C>T	ENST00000322231.7	+	9	1453	c.963C>T	c.(961-963)ggC>ggT	p.G321G	KLHL7_ENST00000542558.1_Silent_p.G118G|KLHL7_ENST00000409689.1_Silent_p.G295G|KLHL7_ENST00000339077.4_Silent_p.G343G|KLHL7_ENST00000539124.1_Silent_p.G267G|KLHL7_ENST00000545443.1_Silent_p.G321G			Q8IXQ5	KLHL7_HUMAN	kelch-like family member 7	343						Golgi apparatus|nucleolus|plasma membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TTTTGGGAGGCTCTCAGCTTT	0.473000													11	41					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150643989	150643989	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150643989G>A	ENST00000392968.2	-	12	4138	c.3018C>T	c.(3016-3018)acC>acT	p.T1006T	KCNH2_ENST00000330883.4_Silent_p.T762T|KCNH2_ENST00000262186.5_Silent_p.T1102T			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	1102					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CCAAGGTGAGGGTGGGGAGGG	0.652000													27	36					0	0	1	0	0
YJEFN3	374887	broad.mit.edu	37	19	19648259	19648259	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19648259C>T	ENST00000514277.3	+	7	861	c.826C>T	c.(826-828)Ccc>Tcc	p.P276S	YJEFN3_ENST00000436027.4_Missense_Mutation_p.P226S	NM_198537.3	NP_940939.2	A6XGL0	YJEN3_HUMAN	YjeF N-terminal domain containing 3	276	YjeF N-terminal.									NS(1)|breast(1)|lung(3)	5						CAGGTTCGTGCCCGATGACGT	0.736000													8	7					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55566511	55566511	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:55566511G>A	ENST00000373965.2	-	36	5277	c.4883C>T	c.(4882-4884)gCg>gTg	p.A1628V	PCDH15_ENST00000414778.1_Missense_Mutation_p.A1625V	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGGCTTCACCGCTGTATTGTC	0.448000										HNSCC(58;0.16)			70	103					0	0	1	0	0
C18orf8	29919	broad.mit.edu	37	18	21107861	21107861	+	Missense_Mutation	SNP	C	C	T	rs139487898	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:21107861C>T	ENST00000269221.3	+	14	1402	c.1292C>T	c.(1291-1293)gCg>gTg	p.A431V	C18orf8_ENST00000590868.1_Missense_Mutation_p.A383V	NM_013326.3	NP_037458.3	Q96DM3	MIC1_HUMAN	chromosome 18 open reading frame 8	431								p.A431V(1)		endometrium(9)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	21	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CAGAGTTATGCGATGGTGAGT	0.433000													11	18					0	0	1	0	0
PEX10	5192	broad.mit.edu	37	1	2340272	2340272	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:2340272G>A	ENST00000288774.3	-	3	246	c.219C>T	c.(217-219)taC>taT	p.Y73Y	PEX10_ENST00000447513.2_Silent_p.Y73Y|PEX10_ENST00000507596.1_Silent_p.Y73Y|PEX10_ENST00000515760.1_5'UTR	NM_153818.1	NP_722540.1	O60683	PEX10_HUMAN	peroxisomal biogenesis factor 10	73					protein import into peroxisome matrix	integral to peroxisomal membrane|peroxisomal membrane	protein binding|protein C-terminus binding|zinc ion binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(2)	7	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.1e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.02e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00102)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0169)|Lung(427;0.199)		TGATGCTGACGTACTCCTCCC	0.672000													9	21					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247582322	247582322	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247582322G>A	ENST00000366497.2	+	2	1006	c.226G>A	c.(226-228)Gct>Act	p.A76T	NLRP3_ENST00000391828.3_Missense_Mutation_p.A76T|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000336119.3_Missense_Mutation_p.A76T|NLRP3_ENST00000348069.2_Missense_Mutation_p.A76T|NLRP3_ENST00000366496.2_Missense_Mutation_p.A76T|NLRP3_ENST00000391827.2_Missense_Mutation_p.A76T	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	76	DAPIN.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GTGGATCTTCGCTGCGATCAA	0.507000													8	15					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112616740	112616740	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112616740G>A	ENST00000550722.1	-	64	11315	c.10920C>T	c.(10918-10920)agC>agT	p.S3640S	HECTD4_ENST00000377560.5_Silent_p.S3614S|HECTD4_ENST00000430131.2_Silent_p.S3364S	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CGCACCTGACGCTGTTGAGCA	0.677000													12	11					0	0	1	0	0
RIMKLB	57494	broad.mit.edu	37	12	8906616	8906616	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:8906616C>T	ENST00000357529.3	+	6	1886	c.624C>T	c.(622-624)gtC>gtT	p.V208V	RIMKLB_ENST00000535829.1_Silent_p.V208V|RIMKLB_ENST00000299673.5_3'UTR|RIMKLB_ENST00000538135.1_Silent_p.V208V	NM_020734.2	NP_065785.2	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family member B	208	ATP-grasp.				protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						GTGTCATTGTCGTGGGAGGCC	0.443000													34	52					0	0	1	0	0
PTPRA	0	broad.mit.edu	37	20	3007406	3007406	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:3007406G>A	ENST00000216877.6	+	17	2061	c.1661G>A	c.(1660-1662)cGt>cAt	p.R554H	PTPRA_ENST00000399903.2_Missense_Mutation_p.R563H|PTPRA_ENST00000425918.2_Missense_Mutation_p.R574H|PTPRA_ENST00000380393.3_Missense_Mutation_p.R563H|PTPRA_ENST00000356147.3_Missense_Mutation_p.R554H|PTPRA_ENST00000358719.4_Missense_Mutation_p.R419H|PTPRA_ENST00000318266.5_Missense_Mutation_p.R554H	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	563	Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						AAGAAGAACCGTGTTTTACAG	0.473000													17	15					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240070781	240070781	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:240070781G>A	ENST00000255380.4	+	5	809	c.30G>A	c.(28-30)tcG>tcA	p.S10S		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	10					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GTACAACCTCGCCTTTGTTTC	0.483000													16	36					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108862959	108862959	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:108862959C>T	ENST00000356922.4	-	2	930	c.658G>A	c.(658-660)Gat>Aat	p.D220N	LIG4_ENST00000405925.1_Missense_Mutation_p.D220N|LIG4_ENST00000442234.1_Missense_Mutation_p.D220N	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	220					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TTTTCCAGATCTGTAGTGACA	0.358000								Non-homologous end-joining					26	51					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75102123	75102123	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:75102123C>T	ENST00000326665.5	-	6	663		c.e6-1			NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173											NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GAGGGGCTGTCTAGACAATTA	0.393000													55	100					0	0	1	0	0
WNT1	7471	broad.mit.edu	37	12	49375049	49375049	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49375049C>T	ENST00000293549.3	+	4	775	c.739C>T	c.(739-741)Cgc>Tgc	p.R247C		NM_005430.3	NP_005421.1	P04628	WNT1_HUMAN	wingless-type MMTV integration site family, member 1	247					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(357;0.244)		CGATGTGCTGCGCGACCGCTT	0.731000													4	4					0	0	1	0	0
REG4	83998	broad.mit.edu	37	1	120342445	120342445	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:120342445G>A	ENST00000354219.1	-	5	645	c.206C>T	c.(205-207)tCt>tTt	p.S69F	REG4_ENST00000530654.1_Missense_Mutation_p.S69F|REG4_ENST00000256585.5_Missense_Mutation_p.S69F	NM_001159352.1	NP_001152824.1	Q9BYZ8	REG4_HUMAN	regenerating islet-derived family, member 4	69	C-type lectin.					extracellular region	sugar binding			central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(2)|prostate(1)|skin(2)	15	all_cancers(5;4.81e-10)|all_epithelial(5;7.98e-11)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;8.1e-07)|Lung NSC(69;5.89e-06)|all_epithelial(167;0.000959)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0588)		ACTCAGGATAGATGCCAGGTG	0.502000													65	85					0	0	1	0	0
PHF10	55274	broad.mit.edu	37	6	170105319	170105319	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:170105319G>A	ENST00000339209.4	-	11	1444	c.1321C>T	c.(1321-1323)Caa>Taa	p.Q441*	C6orf120_ENST00000332290.2_3'UTR|PHF10_ENST00000366780.4_Nonsense_Mutation_p.Q439*	NM_018288.3|NM_133325.2	NP_060758.2|NP_579866.2	Q8WUB8	PHF10_HUMAN	PHD finger protein 10	441					nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	npBAF complex	zinc ion binding			endometrium(2)|large_intestine(2)|liver(3)|lung(4)|prostate(2)|urinary_tract(1)	14		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.4e-21)|BRCA - Breast invasive adenocarcinoma(81;1.4e-07)|GBM - Glioblastoma multiforme(31;0.00176)		TGGTGGGGTTGTCCACATATA	0.408000													25	28					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8825585	8825585	+	Silent	SNP	G	G	A	rs148473485		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:8825585G>A	ENST00000359865.3	+	15	4219	c.4077G>A	c.(4075-4077)tcG>tcA	p.S1359S	SOGA2_ENST00000400050.3_Silent_p.S1318S|SOGA2_ENST00000306329.11_Silent_p.S1678S|SOGA2_ENST00000518815.1_Silent_p.S684S|SOGA2_ENST00000306285.7_Silent_p.S684S|SOGA2_ENST00000517570.1_Silent_p.S1318S	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1669																	CACCCGTGTCGTCTCCTTCCC	0.622000													16	20					0	0	1	0	0
ZNF416	55659	broad.mit.edu	37	19	58084040	58084040	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58084040T>G	ENST00000196489.3	-	4	1454	c.1232A>C	c.(1231-1233)gAg>gCg	p.E411A		NM_017879.1	NP_060349.1	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	411					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(5)|lung(12)|prostate(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		CTGGCCACACTCATAAGGCCT	0.463000													32	57					0	0	1	0	0
HEMK1	51409	broad.mit.edu	37	3	50609161	50609161	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50609161A>G	ENST00000232854.4	+	3	801	c.249A>G	c.(247-249)gcA>gcG	p.A83A	HEMK1_ENST00000434410.1_Silent_p.A83A|HEMK1_ENST00000455834.1_Silent_p.A83A	NM_016173.3	NP_057257.1	Q9Y5R4	HEMK1_HUMAN	HemK methyltransferase family member 1	83					DNA methylation		DNA binding|N-methyltransferase activity|protein methyltransferase activity			lung(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000283)|KIRC - Kidney renal clear cell carcinoma(197;0.0179)|Kidney(197;0.0212)		TGAGGCCGGCACTTTGGACCC	0.567000											OREG0015589	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	68					0	0	1	0	0
VPS53	55275	broad.mit.edu	37	17	526807	526807	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:526807C>T	ENST00000437048.2	-	11	1228	c.1082G>A	c.(1081-1083)cGc>cAc	p.R361H	VPS53_ENST00000571805.1_Missense_Mutation_p.R361H|VPS53_ENST00000291074.5_Missense_Mutation_p.R332H|VPS53_ENST00000576149.1_5'UTR|VPS53_ENST00000574029.1_Intron|VPS53_ENST00000401468.3_Intron|VPS53_ENST00000446250.2_Missense_Mutation_p.R163H	NM_001128159.2	NP_001121631.1	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 homolog (S. cerevisiae)	361					protein transport	endosome membrane|Golgi apparatus				breast(1)|endometrium(4)|large_intestine(5)|lung(8)|prostate(1)	19				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		GCCGGAGAAGCGTTTTGCAAG	0.488000													11	43					0	0	1	0	0
TRPV3	162514	broad.mit.edu	37	17	3427532	3427532	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3427532C>T	ENST00000301365.4	-	13	1834	c.1703G>A	c.(1702-1704)gGt>gAt	p.G568D	TRPV3_ENST00000572519.1_Missense_Mutation_p.G568D|TRPV3_ENST00000576742.1_Missense_Mutation_p.G568D			Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel, subfamily V, member 3	568						integral to membrane	calcium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(12)|ovary(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	35					Menthol(DB00825)	GGACTGGAAACCCCGCGTATA	0.587000													29	68					0	0	1	0	0
ALG9	79796	broad.mit.edu	37	11	111657126	111657126	+	Missense_Mutation	SNP	C	C	A	rs590073		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:111657126C>A	ENST00000398006.2	-	15	2226	c.1318G>T	c.(1318-1320)Ggt>Tgt	p.G440C	ALG9_ENST00000527228.1_5'UTR|ALG9_ENST00000531154.1_Missense_Mutation_p.G447C|ALG9_ENST00000524880.1_3'UTR	NM_001077690.1|NM_001077691.1|NM_001077692.1	NP_001071158.1|NP_001071159.1|NP_001071160.1	Q9H6U8	ALG9_HUMAN	ALG9, alpha-1,2-mannosyltransferase	611					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		TGTTGCTAACCTCCACTTTTC	0.453000													41	90					3.54561e-26	3.96178e-26	1	1	0
JMJD1C	221037	broad.mit.edu	37	10	64952885	64952885	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:64952885A>G	ENST00000399262.2	-	16	6107	c.5889T>C	c.(5887-5889)agT>agC	p.S1963S	JMJD1C_ENST00000542921.1_Silent_p.S1781S|JMJD1C_ENST00000402544.1_Intron|JMJD1C_ENST00000399251.1_3'UTR	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	1963					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					AAATTTTATTACTGTGATTAA	0.353000													20	34					0	0	1	0	0
CCDC159	126075	broad.mit.edu	37	19	11464166	11464166	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11464166G>A	ENST00000588790.1	+	10	1054	c.607G>A	c.(607-609)Gcc>Acc	p.A203T	CCDC159_ENST00000458408.1_Missense_Mutation_p.A203T			P0C7I6	CC159_HUMAN	coiled-coil domain containing 159	318										endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	5						TGAGACAGCCGCCTGTCCGGA	0.547000													4	3					0	0	1	0	0
GBA2	57704	broad.mit.edu	37	9	35740294	35740294	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35740294G>A	ENST00000378094.4	-	7	1708	c.1195C>T	c.(1195-1197)Cga>Tga	p.R399*	GBA2_ENST00000467252.1_5'UTR|GBA2_ENST00000378103.3_Nonsense_Mutation_p.R399*|GBA2_ENST00000545786.1_Nonsense_Mutation_p.R405*			Q9HCG7	GBA2_HUMAN	glucosidase, beta (bile acid) 2	399					bile acid metabolic process|glucosylceramide catabolic process|O-glycoside catabolic process	integral to membrane|microsome|plasma membrane|smooth endoplasmic reticulum	beta-glucosidase activity|glucosylceramidase activity			NS(1)|kidney(3)|large_intestine(5)|lung(5)|ovary(4)|skin(3)	21	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CCTCGAGGTCGCAACTTGCTG	0.552000													18	23					0	0	1	0	0
MC5R	4161	broad.mit.edu	37	18	13826321	13826321	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:13826321T>C	ENST00000324750.3	+	1	779	c.557T>C	c.(556-558)gTc>gCc	p.V186A		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	186					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						TCCACCTACGTCATCCTGTGC	0.567000													19	375					0	0	1	0	0
TMX2	51075	broad.mit.edu	37	11	57505473	57505473	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57505473C>T	ENST00000278422.4	+	3	351	c.339C>T	c.(337-339)ggC>ggT	p.G113G	TMX2_ENST00000378312.4_Intron|TMX2-CTNND1_ENST00000528395.1_Intron	NM_015959.3	NP_057043.1	Q9Y320	TMX2_HUMAN	thioredoxin-related transmembrane protein 2	113					cell redox homeostasis	integral to membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(2)	12						TTCGCATGGGCCTACTTTACA	0.393000													48	52					0	0	1	0	0
KRI1	65095	broad.mit.edu	37	19	10670333	10670333	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10670333G>A	ENST00000312962.6	-	11	1016	c.997C>T	c.(997-999)Cgc>Tgc	p.R333C	KRI1_ENST00000361821.5_Missense_Mutation_p.R329C	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	333	Glu-rich.									NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			TCCTTTCTGCGCTCATCCTTA	0.617000													16	24					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39962264	39962264	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39962264G>A	ENST00000599117.1	+	21	2211	c.1844G>A	c.(1843-1845)cGc>cAc	p.R615H	SUPT5H_ENST00000432763.2_Missense_Mutation_p.R615H|SUPT5H_ENST00000598725.1_Missense_Mutation_p.R615H|SUPT5H_ENST00000402194.2_Missense_Mutation_p.R611H|SUPT5H_ENST00000359191.6_Missense_Mutation_p.R611H			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	615	KOW 4.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGGGAGATTCGCCATCTCTTC	0.577000													24	16					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39711940	39711940	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:39711940A>G	ENST00000395670.3	-	28	4262	c.3843T>C	c.(3841-3843)cgT>cgC	p.R1281R	KIF21A_ENST00000547745.1_Intron|KIF21A_ENST00000544797.2_Silent_p.R1261R|KIF21A_ENST00000541463.2_Silent_p.R1245R|KIF21A_ENST00000361418.5_Silent_p.R1281R|KIF21A_ENST00000361961.3_Silent_p.R1268R			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1281					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TCAGTTCATTACGGGGCCGGC	0.403000													25	34					0	0	1	0	0
PANK1	53354	broad.mit.edu	37	10	91371602	91371602	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:91371602G>A	ENST00000307534.4	-	2	1062	c.907C>T	c.(907-909)Cgc>Tgc	p.R303C	PANK1_ENST00000322191.6_Missense_Mutation_p.R78C|PANK1_ENST00000371774.2_Missense_Mutation_p.R105C|PANK1_ENST00000342512.3_Missense_Mutation_p.R78C	NM_148977.2	NP_683878.1	Q8TE04	PANK1_HUMAN	pantothenate kinase 1	303					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity			cervix(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)	11					Bezafibrate(DB01393)	TTCCCTTTGCGTCCACACATG	0.502000													8	47					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18148550	18148550	+	Missense_Mutation	SNP	G	G	A	rs138406094		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18148550G>A	ENST00000327031.4	-	30	3937	c.3712C>T	c.(3712-3714)Cgg>Tgg	p.R1238W	FLII_ENST00000379450.4_Missense_Mutation_p.R1152W|FLII_ENST00000578558.1_Silent_p.S647S|FLII_ENST00000545457.2_Missense_Mutation_p.R1183W|FLII_ENST00000579294.1_Missense_Mutation_p.R1227W	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	1238					multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					CGGCGCGGCCGCTCATGTTCC	0.657000													58	55					0	0	1	0	0
PSMA4	5685	broad.mit.edu	37	15	78838015	78838015	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:78838015G>A	ENST00000044462.7	+	7	566	c.416G>A	c.(415-417)tGg>tAg	p.W139*	PSMA4_ENST00000558341.1_Intron|PSMA4_ENST00000559082.1_Nonsense_Mutation_p.W139*|PSMA4_ENST00000558281.1_Nonsense_Mutation_p.W139*|PSMA4_ENST00000558094.1_Nonsense_Mutation_p.W51*|PSMA4_ENST00000557929.1_3'UTR|PSMA4_ENST00000413382.2_Nonsense_Mutation_p.W68*|PSMA4_ENST00000560217.1_Nonsense_Mutation_p.W108*	NM_002789.4	NP_002780.1	P25789	PSA4_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 4	139					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity			kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9						TACATTGGCTGGGATAAGCAC	0.393000													48	79					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9246171	9246171	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:9246171T>C	ENST00000318602.7	-	18	2437	c.2130A>G	c.(2128-2130)tcA>tcG	p.S710S		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	710	Bait region.				blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding	p.S710S(1)		breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	CCATTACATCTGACTCTATGG	0.418000													12	18					0	0	1	0	0
STXBP1	6812	broad.mit.edu	37	9	130438090	130438090	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130438090C>T	ENST00000373302.3	+	14	1257	c.1118C>T	c.(1117-1119)gCc>gTc	p.A373V	STXBP1_ENST00000373299.1_Missense_Mutation_p.A373V|STXBP1_ENST00000481942.1_3'UTR	NM_003165.3	NP_003156.1	P61764	STXB1_HUMAN	syntaxin binding protein 1	373					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|skin(2)	23						TAGGACCTGGCCATGGGCACA	0.498000													10	12					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6553496	6553496	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:6553496C>T	ENST00000321612.6	-	20	2479	c.2329G>A	c.(2329-2331)Gcc>Acc	p.A777T		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	777					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AAAAACGGGGCGAGATGTTTC	0.473000													5	107					0	0	1	0	0
TMEM184A	202915	broad.mit.edu	37	7	1587403	1587403	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:1587403G>A	ENST00000297477.5	-	8	1303	c.987C>T	c.(985-987)taC>taT	p.Y329Y		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	329						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		TCTTCTCTGCGTACACCTGGC	0.647000													5	13					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11325274	11325274	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11325274G>A	ENST00000294618.7	-	33	4169	c.4158C>T	c.(4156-4158)acC>acT	p.T1386T	CTC-510F12.2_ENST00000588634.1_RNA|DOCK6_ENST00000319867.7_Silent_p.T725T	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1386					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						GGCTTGCCTCGGTTGCCAGGT	0.582000													8	34					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149460482	149460482	+	Missense_Mutation	SNP	C	C	T	rs144261133		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149460482C>T	ENST00000286301.3	-	3	446	c.155G>A	c.(154-156)gGc>gAc	p.G52D	CSF1R_ENST00000543093.1_Missense_Mutation_p.G52D	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	52	Ig-like C2-type 1.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	TGATGGGGGGCCATCCCATTC	0.587000													13	13					0	0	1	0	0
THEMIS2	9473	broad.mit.edu	37	1	28209434	28209434	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:28209434C>T	ENST00000373921.3	+	4	1603	c.1599C>T	c.(1597-1599)gaC>gaT	p.D533D	THEMIS2_ENST00000373925.1_Intron|THEMIS2_ENST00000328928.7_Silent_p.D404D|THEMIS2_ENST00000373927.3_Intron	NM_001105556.1	NP_001099026.1			thymocyte selection associated family member 2																		AGCTGACAGACACCTTCTATT	0.592000													5	64					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172166029	172166029	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:172166029C>T	ENST00000241256.2	-	1	217	c.175G>A	c.(175-177)Gct>Act	p.A59T	GHSR_ENST00000427970.1_Missense_Mutation_p.A59T	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	59					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			AGGTTGCCAGCGATGCCCACC	0.667000													8	14					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123830009	123830009	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:123830009G>A	ENST00000420886.2	-	3	345	c.346C>T	c.(346-348)Caa>Taa	p.Q116*	SBNO1_ENST00000267176.4_Nonsense_Mutation_p.Q115*|SBNO1_ENST00000602398.1_Nonsense_Mutation_p.Q116*|SBNO1_ENST00000602750.1_Nonsense_Mutation_p.Q115*	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	116							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GTGATGGTTTGCCTGTTGGTT	0.423000													23	44					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50730173	50730173	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50730173G>A	ENST00000440075.2	+	8	871	c.824G>A	c.(823-825)cGc>cAc	p.R275H	MYH14_ENST00000425460.1_Missense_Mutation_p.R275H|MYH14_ENST00000376970.2_Missense_Mutation_p.R267H|MYH14_ENST00000262269.8_Missense_Mutation_p.R275H|MYH14_ENST00000601313.1_Missense_Mutation_p.R275H|MYH14_ENST00000598205.1_Missense_Mutation_p.R275H|MYH14_ENST00000596571.1_Missense_Mutation_p.R267H			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	267	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		AAATTCATCCGCATCAACTTT	0.587000													16	41					0	0	1	0	0
E2F8	79733	broad.mit.edu	37	11	19251025	19251025	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:19251025T>C	ENST00000527884.1	-	10	2101	c.1869A>G	c.(1867-1869)ctA>ctG	p.L623L	RP11-428C19.4_ENST00000527978.1_RNA|E2F8_ENST00000250024.4_Silent_p.L623L	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	623					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CAAGTCCTTTTAGGTCCTCTT	0.463000													39	59					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18918411	18918411	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18918411G>A	ENST00000317977.6	+	10	1510	c.939G>A	c.(937-939)tcG>tcA	p.S313S	SLC5A10_ENST00000395645.3_Silent_p.S380S|SLC5A10_ENST00000417251.2_Silent_p.S344S|SLC5A10_ENST00000395642.1_Silent_p.S313S|SLC5A10_ENST00000395643.2_Silent_p.S353S|SLC5A10_ENST00000395647.2_Silent_p.S396S			A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	380					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						TCATGTCGTCGCTGACCTCCA	0.667000													16	23					0	0	1	0	0
FANCC	2176	broad.mit.edu	37	9	97873813	97873813	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:97873813C>T	ENST00000289081.3	-	13	1515	c.1261G>A	c.(1261-1263)Gcc>Acc	p.A421T	FANCC_ENST00000375305.1_Missense_Mutation_p.A421T	NM_000136.2	NP_000127.2	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	421					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)|skin(1)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(62;0.138)				CACAGCAGGGCCGTGGGGGGT	0.602000			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				5	39					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56088268	56088268	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56088268G>A	ENST00000257880.7	-	18	2667	c.2448C>T	c.(2446-2448)agC>agT	p.S816S	ITGA7_ENST00000555728.1_Silent_p.S816S|ITGA7_ENST00000257879.6_Silent_p.S772S|ITGA7_ENST00000553804.1_Silent_p.S776S|ITGA7_ENST00000452168.2_Silent_p.S679S|ITGA7_ENST00000394229.2_Silent_p.S772S|ITGA7_ENST00000394230.2_Silent_p.S776S|ITGA7_ENST00000347027.6_Silent_p.S766S			Q13683	ITA7_HUMAN	integrin, alpha 7	816					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						TGGTCTCAATGCTGATCCCGG	0.572000													6	7					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101778332	101778332	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:101778332C>T	ENST00000375001.3	+	11	2001	c.1578C>T	c.(1576-1578)tcC>tcT	p.S526S		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	526	4 X tandem repeats.|Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GTGAAGAGTCCGGCAGCCCTC	0.557000													4	12					0	0	1	0	0
MLK4	0	broad.mit.edu	37	1	233482357	233482357	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:233482357C>T	ENST00000366624.3	+	2	1236	c.975C>T	c.(973-975)agC>agT	p.S325S	MLK4_ENST00000366623.3_Silent_p.S325S	NM_032435.2	NP_115811.2																					CTAAGGGAAGCGACATCTGGA	0.478000													14	20					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33923389	33923389	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:33923389C>T	ENST00000379238.1	-	25	3001	c.2884G>A	c.(2884-2886)Ggc>Agc	p.G962S	UBAP2_ENST00000379239.4_Missense_Mutation_p.G695S|UBAP2_ENST00000539807.1_Missense_Mutation_p.G717S|UBAP2_ENST00000379235.1_Missense_Mutation_p.G201S|UBAP2_ENST00000449054.1_Missense_Mutation_p.G962S|UBAP2_ENST00000360802.1_Missense_Mutation_p.G962S			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	962										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GTACTGTAGCCGTGCTGGCCA	0.602000													5	215					0	0	1	0	0
IL16	3603	broad.mit.edu	37	15	81585159	81585159	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:81585159G>A	ENST00000394660.2	+	12	2043	c.1683G>A	c.(1681-1683)agG>agA	p.R561R	IL16_ENST00000302987.4_Silent_p.R561R	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	561					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						CATCCTCCAGGCTGCCCCAGG	0.597000													13	15					0	0	1	0	0
FOXRED2	80020	broad.mit.edu	37	22	36900731	36900731	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36900731C>T	ENST00000397224.4	-	3	703	c.610G>A	c.(610-612)Gtg>Atg	p.V204M	FOXRED2_ENST00000397223.4_Missense_Mutation_p.V204M|FOXRED2_ENST00000216187.6_Missense_Mutation_p.V204M	NM_001102371.1	NP_001095841.1	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	204					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						TCCACGGACACGGACTCGTAA	0.557000													8	17					0	0	1	0	0
HPSE	10855	broad.mit.edu	37	4	84231935	84231935	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:84231935G>A	ENST00000405413.2	-	6	918	c.782C>T	c.(781-783)gCa>gTa	p.A261V	HPSE_ENST00000512196.1_Missense_Mutation_p.A261V|HPSE_ENST00000311412.5_Missense_Mutation_p.A261V|HPSE_ENST00000513463.1_Missense_Mutation_p.A203V	NM_006665.5	NP_006656.2	Q9Y251	HPSE_HUMAN	heparanase	261					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	ATAGAGTTTTGCATTTTTGAA	0.388000													6	159					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35545171	35545171	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:35545171C>T	ENST00000262878.4	-	9	1215	c.1016G>A	c.(1015-1017)cGt>cAt	p.R339H	SAMHD1_ENST00000373694.5_Missense_Mutation_p.R124H	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	339					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				TTCACAGACACGGGCAAACTT	0.383000													70	119					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96875259	96875259	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:96875259G>A	ENST00000267584.4	+	4	523	c.479G>A	c.(478-480)cGc>cAc	p.R160H	AK7_ENST00000554313.1_3'UTR	NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	160					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		ACTTGGGCGCGCTCCAAAGCC	0.478000													18	13					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132502188	132502188	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:132502188C>T	ENST00000333577.4	+	21	4249	c.4140C>T	c.(4138-4140)ggC>ggT	p.G1380G	EP400_ENST00000332482.4_Silent_p.G1307G|EP400_ENST00000389561.2_Silent_p.G1344G|EP400_ENST00000389562.2_Silent_p.G1343G|EP400_ENST00000330386.6_Silent_p.G1344G			Q96L91	EP400_HUMAN	E1A binding protein p400	1380					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGCACCCAGGCTCTTCCTACG	0.597000													19	22					0	0	1	0	0
ZNF3	7551	broad.mit.edu	37	7	99672820	99672820	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99672820G>T	ENST00000303915.6	-	4	1176	c.209C>A	c.(208-210)cCt>cAt	p.P70H	ZNF3_ENST00000424697.1_Missense_Mutation_p.P70H|ZNF3_ENST00000299667.4_Missense_Mutation_p.P70H|ZNF3_ENST00000413658.2_Missense_Mutation_p.P70H			P17036	ZNF3_HUMAN	zinc finger protein 3	70	KRAB.				cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	25	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			CCTCTGAGCAGGTTCCAAACG	0.488000													24	96					9.90768e-06	1.02613e-05	1	1	0
GRM2	2912	broad.mit.edu	37	3	51749519	51749519	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:51749519T>C	ENST00000395052.3	+	4	1964	c.1730T>C	c.(1729-1731)cTc>cCc	p.L577P	GRM2_ENST00000475478.1_3'UTR|GRM2_ENST00000442933.2_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	577					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	ATCGCCTGCCTCGGTGCCCTG	0.632000													26	32					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42512492	42512492	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42512492G>A	ENST00000434000.1	-	6	337	c.55C>T	c.(55-57)Cgg>Tgg	p.R19W	GPATCH8_ENST00000586265.1_5'UTR|GPATCH8_ENST00000591680.1_Missense_Mutation_p.R97W			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	97						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ACACGGCGCCGTTCGGTAGCA	0.383000													41	49					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114276470	114276470	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:114276470G>A	ENST00000357077.4	+	38	6749	c.6696G>A	c.(6694-6696)aaG>aaA	p.K2232K	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Silent_p.K2199K|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2199					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAAGCTATAAGCATGAAGGCC	0.512000													5	39					0	0	1	0	0
ALG10B	144245	broad.mit.edu	37	12	38714692	38714692	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:38714692G>A	ENST00000308742.4	+	3	1415	c.1099G>A	c.(1099-1101)Gca>Aca	p.A367T	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	367					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TCAAAGATATGCAATTCTGAA	0.299000													32	56					0	0	1	0	0
RHOBTB3	22836	broad.mit.edu	37	5	95091344	95091344	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:95091344C>G	ENST00000379982.3	+	6	1435	c.927C>G	c.(925-927)aaC>aaG	p.N309K	GLRX_ENST00000508780.1_Intron	NM_014899.3	NP_055714.3	O94955	RHBT3_HUMAN	Rho-related BTB domain containing 3	309	BTB 1.				retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|skin(1)	16		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		TTGCTATAAACAGAGATACTG	0.428000													28	42					0	0	1	0	0
PCYT1A	5130	broad.mit.edu	37	3	195975094	195975094	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195975094C>T	ENST00000292823.2	-	5	490	c.318G>A	c.(316-318)acG>acA	p.T106T	PCYT1A_ENST00000491544.1_5'UTR|PCYT1A_ENST00000419333.1_Silent_p.T106T|PCYT1A_ENST00000431016.1_Silent_p.T106T	NM_005017.2	NP_005008.2	P49585	PCY1A_HUMAN	phosphate cytidylyltransferase 1, choline, alpha	106	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity			cervix(1)|endometrium(3)|large_intestine(8)|lung(5)|ovary(1)	18	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	CAATGAGGTACGTATTAGGGA	0.458000													46	66					0	0	1	0	0
DAND5	199699	broad.mit.edu	37	19	13080429	13080429	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13080429C>T	ENST00000585548.1	+	2	141	c.45C>T	c.(43-45)agC>agT	p.S15S	DAND5_ENST00000317060.2_5'UTR			Q8N907	DAND5_HUMAN	DAN domain family member 5, BMP antagonist	0						extracellular region				kidney(2)|lung(3)|ovary(1)	6			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			TGACCTTGAGCCCAGTCCGga	0.587000													19	27					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122755608	122755608	+	Silent	SNP	C	C	T	rs150844958		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:122755608C>T	ENST00000194130.2	-	15	1791	c.1752G>A	c.(1750-1752)tcG>tcA	p.S584S	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	584						integral to membrane|plasma membrane	sodium:sulfate symporter activity	p.S584S(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	CAGGAGCCCACGAAGGGTAAG	0.403000													18	26					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33272105	33272105	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33272105C>T	ENST00000373477.4	-	4	1396	c.488G>A	c.(487-489)gGc>gAc	p.G163D		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	163					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	GTATAAGAGGCCACTCAGCAA	0.522000													57	81					0	0	1	0	0
HYAL2	8692	broad.mit.edu	37	3	50356445	50356445	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50356445G>A	ENST00000447092.1	-	2	3245	c.953C>T	c.(952-954)gCg>gTg	p.A318V	HYAL2_ENST00000395139.3_Missense_Mutation_p.A318V|HYAL2_ENST00000357750.4_Missense_Mutation_p.A318V|HYAL2_ENST00000442581.1_Missense_Mutation_p.A318V			Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2	318						anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			breast(1)|endometrium(2)|kidney(1)|ovary(1)|prostate(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	GCCCAGGGCCGCACTCTCGCC	0.597000													15	35					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21213057	21213057	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:21213057G>A	ENST00000574002.1	-	14	1956	c.1474C>T	c.(1474-1476)Cca>Tca	p.P492S	AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000574091.1_Missense_Mutation_p.P483S|ZP2_ENST00000219593.4_Missense_Mutation_p.P492S			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	492	ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		AAGGTAAATGGACCCAACTTC	0.413000													6	99					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67293842	67293842	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67293842G>A	ENST00000299798.11	+	12	1900	c.1835G>A	c.(1834-1836)cGc>cAc	p.R612H		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	612					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		TACAAGCCGCGCCGTAGGGTG	0.597000													4	19					0	0	1	0	0
ZNF668	79759	broad.mit.edu	37	16	31072558	31072558	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31072558C>T	ENST00000538906.1	-	3	2475	c.1691G>A	c.(1690-1692)cGc>cAc	p.R564H	ZNF668_ENST00000539836.3_Missense_Mutation_p.R587H|ZNF668_ENST00000535577.1_Missense_Mutation_p.R564H|ZNF668_ENST00000394983.2_Missense_Mutation_p.R564H|ZNF668_ENST00000300849.4_Missense_Mutation_p.R564H|ZNF668_ENST00000426488.2_Missense_Mutation_p.R587H	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	564					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GCTGTGAGTGCGGCTGTGTTT	0.667000													9	48					0	0	1	0	0
MRPL10	124995	broad.mit.edu	37	17	45901638	45901638	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:45901638T>A	ENST00000290208.7	-	5	1201	c.749A>T	c.(748-750)cAa>cTa	p.Q250L	MRPL10_ENST00000414011.1_Missense_Mutation_p.Q250L|MRPL10_ENST00000351111.2_Missense_Mutation_p.Q240L			Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10	240					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			endometrium(3)|large_intestine(1)|lung(3)|ovary(1)	8						CTTCTCGCGTTGCTCTCTGAT	0.587000													17	27					0	0	1	0	0
KLK5	25818	broad.mit.edu	37	19	51451971	51451971	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:51451971G>A	ENST00000336334.3	-	5	1003	c.651C>T	c.(649-651)tgC>tgT	p.C217C	KLK5_ENST00000391809.2_Silent_p.C217C|KLK5_ENST00000593428.1_Silent_p.C217C	NM_012427.4	NP_036559.1	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5	217	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			NS(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		AAGCATCCTCGCACCTTTTCT	0.498000													25	31					0	0	1	0	0
RHOT2	89941	broad.mit.edu	37	16	723548	723548	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:723548C>T	ENST00000315082.4	+	19	1913	c.1799C>T	c.(1798-1800)gCc>gTc	p.A600V		NM_138769.2	NP_620124.1	Q8IXI1	MIRO2_HUMAN	ras homolog family member T2	600	Miro 2.				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|pancreas(2)|prostate(1)	13		Hepatocellular(780;0.0218)				GTTGTCGGGGCCGCCGTGGCC	0.627000													30	47					0	0	1	0	0
DGKE	8526	broad.mit.edu	37	17	54926166	54926166	+	Missense_Mutation	SNP	C	C	T	rs149433337		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:54926166C>T	ENST00000284061.3	+	6	1178	c.998C>T	c.(997-999)gCg>gTg	p.A333V		NM_003647.2	NP_003638.1	P52429	DGKE_HUMAN	diacylglycerol kinase, epsilon 64kDa	333	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(3)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25	Breast(9;3.59e-07)					ATTCCAGTTGCGCAGGTTTTG	0.413000													27	49					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201291157	201291157	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:201291157G>A	ENST00000263946.3	+	9	1713	c.1462G>A	c.(1462-1464)Gcc>Acc	p.A488T	PKP1_ENST00000367324.3_Missense_Mutation_p.A467T|PKP1_ENST00000352845.3_Missense_Mutation_p.A488T	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	488					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						CCGCCTGGACGCCGAGGTGCC	0.617000													7	32					0	0	1	0	0
SOX14	8403	broad.mit.edu	37	3	137483986	137483986	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:137483986C>T	ENST00000306087.1	+	1	408	c.360C>T	c.(358-360)agC>agT	p.S120S		NM_004189.3	NP_004180.1	O95416	SOX14_HUMAN	SRY (sex determining region Y)-box 14	120					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding			large_intestine(2)|lung(12)	14						GCCTCCTGAGCGCGCCCGAGA	0.697000													12	15					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1488475	1488475	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:1488475C>T	ENST00000345913.4	+	9	1537	c.1446C>T	c.(1444-1446)tcC>tcT	p.S482S	TPO_ENST00000329066.4_Silent_p.S482S|TPO_ENST00000382198.1_Silent_p.S309S|TPO_ENST00000346956.3_Silent_p.S482S|TPO_ENST00000349624.3_Silent_p.S309S|TPO_ENST00000337415.3_Silent_p.S482S|TPO_ENST00000382201.3_Silent_p.S482S|TPO_ENST00000497517.2_3'UTR	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	482					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CCACTGTGTCCAACGTGTTCT	0.647000													13	23					0	0	1	0	0
CDC25B	994	broad.mit.edu	37	20	3784075	3784075	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:3784075C>T	ENST00000245960.5	+	14	2078	c.1381C>T	c.(1381-1383)Cgc>Tgc	p.R461C	CDC25B_ENST00000379598.5_Missense_Mutation_p.R370C|CDC25B_ENST00000439880.2_Missense_Mutation_p.R447C|CDC25B_ENST00000467519.1_3'UTR|CDC25B_ENST00000344256.6_Missense_Mutation_p.R397C|CDC25B_ENST00000340833.4_Missense_Mutation_p.R420C	NM_004358.3|NM_021872.2|NM_021873.2	NP_004349.1|NP_068658.1|NP_068659.1	P30305	MPIP2_HUMAN	cell division cycle 25B	461	Rhodanese.				cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			NS(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(1)	18						GCCCCTGGAACGCGACGCCGA	0.612000													26	23					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16328510	16328510	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:16328510C>T	ENST00000244769.4	-	8	968	c.32G>A	c.(31-33)tGc>tAc	p.C11Y	ATXN1_ENST00000436367.1_Missense_Mutation_p.C11Y	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	11					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GGGAGGCAGGCATTCGTTGCT	0.597000													10	13					0	0	1	0	0
PITPNB	23760	broad.mit.edu	37	22	28293810	28293810	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:28293810C>T	ENST00000335272.5	-	4	344	c.268G>A	c.(268-270)Gcg>Acg	p.A90T	PITPNB_ENST00000455418.3_Missense_Mutation_p.A92T|PITPNB_ENST00000320996.10_Missense_Mutation_p.A90T	NM_012399.3	NP_036531.1	P48739	PIPNB_HUMAN	phosphatidylinositol transfer protein, beta	90					lipid metabolic process|transport	Golgi apparatus	lipid binding			large_intestine(4)|lung(3)|skin(1)	8						TAGGGGTACGCATTCCAGGCT	0.507000													10	13					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430806	37430806	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:37430806G>A	ENST00000374660.1	+	7	912	c.813G>A	c.(811-813)gaG>gaA	p.E271E	ANKRD30A_ENST00000361713.1_Silent_p.E271E|ANKRD30A_ENST00000602533.1_Silent_p.E271E			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	327						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CACCTGATGAGGCTGCATCCT	0.473000													15	9					0	0	1	0	0
FGGY	55277	broad.mit.edu	37	1	60073567	60073567	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:60073567C>T	ENST00000371218.4	+	9	1180	c.996C>T	c.(994-996)agC>agT	p.S332S	FGGY_ENST00000371212.1_Silent_p.S244S|FGGY_ENST00000474476.1_3'UTR|FGGY_ENST00000303721.7_Silent_p.S332S|FGGY_ENST00000371210.1_Silent_p.S33S	NM_001113411.1	NP_001106882.1	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	332					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(7;7.36e-05)					GTGGTCAGAGCGTTACTGGAA	0.438000													17	44					0	0	1	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077910	19077910	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:19077910T>C	ENST00000329773.2	-	2	127	c.40A>G	c.(40-42)Aca>Gca	p.T14A		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	14					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						CCATTCACTGTTGTACTTTCT	0.532000													64	112					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67267630	67267630	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67267630G>A	ENST00000356404.3	-	6	1128	c.903C>T	c.(901-903)ccC>ccT	p.P301P	PITPNM1_ENST00000436757.2_Silent_p.P301P|PITPNM1_ENST00000534749.1_Silent_p.P301P	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	301					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						AGCTGGCATCGGGGGAGGCAT	0.687000													16	21					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861265	52861265	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:52861265G>A	ENST00000343457.3	-	4	1929	c.1923C>T	c.(1921-1923)tcC>tcT	p.S641S		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	641						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						CCCTTGCCCCGGACAGCCTTG	0.527000													25	35					0	0	1	0	0
RP4-604K5.1	0	broad.mit.edu	37	1	87379755	87379755	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:87379755G>A	ENST00000331835.5	-	1	293	c.31C>T	c.(31-33)Ccg>Tcg	p.P11S	RP4-604K5.1_ENST00000401030.3_Missense_Mutation_p.P11S|RP4-604K5.1_ENST00000370554.1_Missense_Mutation_p.P11S|RP4-604K5.1_ENST00000469566.1_Intron	NM_004261.3	NP_004252.2																					CCAAACGCCGGCACCAGACAC	0.602000													7	25					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78987844	78987844	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:78987844G>A	ENST00000436010.2	-	2	1286	c.289C>T	c.(289-291)Cgg>Tgg	p.R97W	ROBO1_ENST00000467549.1_Missense_Mutation_p.R97W|ROBO1_ENST00000464233.1_Missense_Mutation_p.R136W|ROBO1_ENST00000495273.1_Missense_Mutation_p.R97W			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	136	Ig-like C2-type 1.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CTACTTTTCCGTCCATGTACT	0.473000													13	10					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133174883	133174883	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:133174883G>A	ENST00000329321.3	+	1	737	c.268G>A	c.(268-270)Gag>Aag	p.E90K		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	90						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CATGCCCATGGAGTTCTACAG	0.547000													31	39					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51492006	51492006	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:51492006G>A	ENST00000298355.3	-	2	2016	c.895C>T	c.(895-897)Cgc>Tgc	p.R299C	TRIM9_ENST00000360392.4_Missense_Mutation_p.R299C|TRIM9_ENST00000338969.5_Missense_Mutation_p.R299C	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	299					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					ACCATGTTGCGCAGCTGTACC	0.552000													69	114					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21993240	21993240	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:21993240G>T	ENST00000327430.3	-	2	916	c.622C>A	c.(622-624)Ctg>Atg	p.L208M	SALL2_ENST00000450879.2_Intron|SALL2_ENST00000317492.5_Intron|SALL2_ENST00000538754.1_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	208							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CCAAGCAACAGCACCTGCCTG	0.592000													13	12					0.00010058	0.000103117	1	1	0
GRIN2C	2905	broad.mit.edu	37	17	72846864	72846864	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72846864C>T	ENST00000293190.5	-	5	1302	c.1156G>A	c.(1156-1158)Gtg>Atg	p.V386M	GRIN2C_ENST00000347612.4_Missense_Mutation_p.V386M	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	386					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CGAGGCCACACGGGGTACTTC	0.657000													6	12					0	0	1	0	0
CRTAP	10491	broad.mit.edu	37	3	33174149	33174149	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:33174149G>T	ENST00000320954.6	+	5	1124	c.1025G>T	c.(1024-1026)aGg>aTg	p.R342M	CRTAP_ENST00000449224.1_Missense_Mutation_p.R299M	NM_006371.4	NP_006362.1	O75718	CRTAP_HUMAN	cartilage associated protein	342						proteinaceous extracellular matrix	binding			breast(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	9						CAGTACCACAGGGACACTTGG	0.517000													31	50					1.08312e-15	1.18619e-15	1	1	0
PANK2	80025	broad.mit.edu	37	20	3888801	3888801	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:3888801G>A	ENST00000316562.4	+	2	863	c.857G>A	c.(856-858)cGc>cAc	p.R286H	PANK2_ENST00000497424.1_5'UTR|PANK2_ENST00000336066.3_Intron	NM_153638.2	NP_705902.2	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2	286			R -> C (in NBIA1).		cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CACTTTATACGCTTTCCCACT	0.502000													36	35					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172013301	172013301	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:172013301A>G	ENST00000336824.4	+	8	1097	c.998A>G	c.(997-999)tAc>tGc	p.Y333C	FNDC3B_ENST00000416957.1_Missense_Mutation_p.Y333C|FNDC3B_ENST00000415807.2_Missense_Mutation_p.Y333C	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	333	Fibronectin type-III 1.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		AAGATAATTTACAGGTTGTGT	0.403000													7	73					0	0	1	0	0
QRICH1	54870	broad.mit.edu	37	3	49094396	49094396	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49094396C>T	ENST00000395443.2	-	3	1709	c.1237G>A	c.(1237-1239)Gtc>Atc	p.V413I	QRICH1_ENST00000479449.1_5'UTR|QRICH1_ENST00000424300.1_Missense_Mutation_p.V413I|QRICH1_ENST00000357496.2_Missense_Mutation_p.V413I	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	413	Gln-rich.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CATATATGGACAGTTTGAGCC	0.537000													11	45					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93073027	93073027	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:93073027C>T	ENST00000359558.2	-	11	1092	c.793G>A	c.(793-795)Gcc>Acc	p.A265T	CALCR_ENST00000421592.1_Missense_Mutation_p.A247T|CALCR_ENST00000426151.1_Missense_Mutation_p.A231T|CALCR_ENST00000360249.4_Missense_Mutation_p.A247T|CALCR_ENST00000394441.1_Missense_Mutation_p.A231T	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	247					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding	p.A231P(1)|p.A265P(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TAGTTGCAGGCCATCATGTAC	0.443000													24	41					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131522167	131522167	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:131522167G>A	ENST00000423981.1	+	2	2632	c.2522G>A	c.(2521-2523)gGc>gAc	p.G841D	AMER3_ENST00000321420.4_Missense_Mutation_p.G841D	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GCCCGTGAGGGCCTCCTCTGT	0.632000													5	9					0	0	1	0	0
CD48	962	broad.mit.edu	37	1	160681528	160681528	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160681528C>T	ENST00000368045.3	-	1	65	c.26G>A	c.(25-27)tGt>tAt	p.C9Y	CD48_ENST00000368046.3_Missense_Mutation_p.C9Y			P09326	CD48_HUMAN	CD48 molecule	9					blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|stomach(1)	10	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CAGAGCCAGACACGAATCCCA	0.522000													14	17					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614342	247614342	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247614342G>A	ENST00000318749.6	-	1	966	c.943C>T	c.(943-945)Ctc>Ttc	p.L315F		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	315					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CATCCACAGAGCCTCCAGATC	0.453000													98	137					0	0	1	0	0
MED25	81857	broad.mit.edu	37	19	50338353	50338353	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50338353C>T	ENST00000312865.6	+	14	1646	c.1593C>T	c.(1591-1593)agC>agT	p.S531S	MED25_ENST00000538643.1_Silent_p.S318S	NM_030973.3	NP_112235.2	Q71SY5	MED25_HUMAN	mediator complex subunit 25	531	Interaction with CREBBP.|Interaction with VP16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm		p.S531S(2)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|stomach(1)|urinary_tract(1)	17		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)		ACGACCAGAGCGGCTTCGTCA	0.607000													9	125					0	0	1	0	0
FBXO27	126433	broad.mit.edu	37	19	39521716	39521716	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39521716C>T	ENST00000292853.4	-	4	644	c.525G>A	c.(523-525)tgG>tgA	p.W175*	CTB-189B5.3_ENST00000597303.1_RNA|FBXO27_ENST00000509137.2_Nonsense_Mutation_p.W175*|FBXO27_ENST00000600828.1_Nonsense_Mutation_p.W174*	NM_178820.3	NP_849142.1	Q8NI29	FBX27_HUMAN	F-box protein 27	175	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|urinary_tract(2)	17	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GCAGTTCTGGCCACAGACCCT	0.507000													21	99					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62415513	62415513	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62415513G>A	ENST00000330574.2	-	2	2091	c.2039C>T	c.(2038-2040)aCa>aTa	p.T680I		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	680					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						AGCTGGGGATGTCTGAGACAG	0.592000													7	20					0	0	1	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117959682	117959682	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:117959682G>A	ENST00000310164.2	+	4	982	c.475G>A	c.(475-477)Gct>Act	p.A159T		NM_173798.2	NP_776159.1	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	22						gctccagaacgctattcaggc	0.502000													23	38					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	129231687	129231687	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:129231687C>T	ENST00000280333.6	+	48	5101	c.4992C>T	c.(4990-4992)tcC>tcT	p.S1664S		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1664					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GACCAGGCTCCGACGGGTGAG	0.597000													11	25					0	0	1	0	0
KLHDC4	54758	broad.mit.edu	37	16	87743136	87743136	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:87743136G>A	ENST00000270583.5	-	10	1240	c.1182C>T	c.(1180-1182)acC>acT	p.T394T	KLHDC4_ENST00000353170.5_Silent_p.T337T|KLHDC4_ENST00000347925.5_Silent_p.T363T|KLHDC4_ENST00000566349.1_5'UTR	NM_017566.3	NP_060036.2	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	394										breast(2)|endometrium(3)|lung(10)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	21				BRCA - Breast invasive adenocarcinoma(80;0.0283)		TGGTGACCACGGTGCCATCCT	0.692000													4	21					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3768889	3768889	+	Missense_Mutation	SNP	G	G	A	rs150169294		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:3768889G>A	ENST00000378230.3	-	2	407	c.83C>T	c.(82-84)gCg>gTg	p.A28V	CEP104_ENST00000378223.3_Missense_Mutation_p.A28V	NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	28						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						GACAGTTGGCGCGTGGATCAT	0.627000													5	22					0	0	1	0	0
KPNA5	3841	broad.mit.edu	37	6	117043316	117043316	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:117043316C>T	ENST00000368564.1	+	9	932	c.784C>T	c.(784-786)Cga>Tga	p.R262*	KPNA5_ENST00000356348.1_Nonsense_Mutation_p.R262*			O15131	IMA5_HUMAN	karyopherin alpha 5 (importin alpha 6)	259					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(6)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		TGTCCTGTCACGACTGTTGTT	0.373000													25	61					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	650773	650773	+	Silent	SNP	C	C	T	rs148190219		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:650773C>T	ENST00000255622.6	+	9	1261	c.1218C>T	c.(1216-1218)gaC>gaT	p.D406D	PDE6B_ENST00000496514.1_Silent_p.D406D|PDE6B_ENST00000429163.2_Silent_p.D127D	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	406	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						ACAGGAAAGACGGGAAGCCCT	0.587000													9	23					0	0	1	0	0
RBM4B	83759	broad.mit.edu	37	11	66436508	66436508	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66436508G>A	ENST00000525754.1	-	2	1335	c.667C>T	c.(667-669)Cga>Tga	p.R223*	RBM4B_ENST00000531969.1_Intron|RBM4B_ENST00000310046.4_Nonsense_Mutation_p.R223*|RBM4B_ENST00000524637.1_3'UTR			Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	223	Interaction with TNPO3 (By similarity).				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(4)|lung(1)|urinary_tract(2)	10						ACCCGGTATCGCTTATAGTAG	0.507000													15	18					0	0	1	0	0
SLC25A18	83733	broad.mit.edu	37	22	18072396	18072396	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:18072396C>T	ENST00000327451.5	+	10	1309	c.771C>T	c.(769-771)ggC>ggT	p.G257G	SLC25A18_ENST00000399813.1_Silent_p.G257G	NM_031481.1	NP_113669.1	Q9H1K4	GHC2_HUMAN	solute carrier family 25 (glutamate carrier), member 18	257						integral to membrane|mitochondrial inner membrane	binding|symporter activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	18				Lung(27;0.124)	L-Glutamic Acid(DB00142)	AAGGCCTGGGCGAGGACATGT	0.507000													10	15					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166785667	166785667	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166785667T>C	ENST00000243344.7	-	11	1501	c.1364A>G	c.(1363-1365)tAt>tGt	p.Y455C		NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	455						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						GAAGCTCAGATACTCCATAAC	0.348000													16	18					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56307518	56307518	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56307518G>A	ENST00000443188.1	-	8	2980	c.2270C>T	c.(2269-2271)cCg>cTg	p.P757L	NLRP11_ENST00000589093.1_Missense_Mutation_p.P757L|NLRP11_ENST00000592953.1_Missense_Mutation_p.P658L|NLRP11_ENST00000360133.3_Missense_Mutation_p.P703L|NLRP11_ENST00000589824.2_Missense_Mutation_p.P703L	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	757							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		GCTCCTCAGCGGATTGCTGGA	0.498000													52	78					0	0	1	0	0
RHO	6010	broad.mit.edu	37	3	129251457	129251457	+	Missense_Mutation	SNP	G	G	A	rs150250946		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:129251457G>A	ENST00000296271.3	+	4	872	c.778G>A	c.(778-780)Gct>Act	p.A260T		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	260					protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding	p.A260T(2)		breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	CATGGTCATCGCTTTCCTGAT	0.602000													17	22					0	0	1	0	0
MIR1283-1	0	broad.mit.edu	37	19	54191763	54191763	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54191763G>A	ENST00000408494.1	+	0	29					NR_031573.1																						AAAGGAAAGCGCTTTCTGTTG	0.408000													48	61					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1584933	1584933	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1584933C>T	ENST00000572621.1	-	5	970	c.705G>A	c.(703-705)atG>atA	p.M235I	PRPF8_ENST00000304992.6_Missense_Mutation_p.M235I			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	235						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		AGAGAGTCGACATCATAGGTA	0.478000													26	62					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53452870	53452870	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53452870C>A	ENST00000314250.6	+	18	1735	c.1445C>A	c.(1444-1446)cCt>cAt	p.P482H	TENC1_ENST00000451358.1_Missense_Mutation_p.P482H|TENC1_ENST00000546602.1_Missense_Mutation_p.P482H|TENC1_ENST00000549700.1_Missense_Mutation_p.P482H|TENC1_ENST00000552570.1_Missense_Mutation_p.P482H|TENC1_ENST00000379902.3_Missense_Mutation_p.P358H|TENC1_ENST00000314276.3_Missense_Mutation_p.P492H	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	482					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						GATGGCAGTCCTTATGCCCAG	0.667000													39	35					4.17593e-13	4.53019e-13	1	1	0
NLRP9	338321	broad.mit.edu	37	19	56228221	56228221	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56228221C>T	ENST00000332836.2	-	5	2230	c.2203G>A	c.(2203-2205)Gcc>Acc	p.A735T		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	735						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AGGACGGAGGCGATGTCTTCA	0.493000													17	29					0	0	1	0	0
POMT1	10585	broad.mit.edu	37	9	134385176	134385176	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:134385176G>A	ENST00000423007.1	+	7	1028	c.586G>A	c.(586-588)Gct>Act	p.A196T	POMT1_ENST00000354713.4_Missense_Mutation_p.A166T|POMT1_ENST00000419118.2_Missense_Mutation_p.A44T|POMT1_ENST00000341012.7_Missense_Mutation_p.A142T|POMT1_ENST00000541219.1_Intron|POMT1_ENST00000404875.2_Missense_Mutation_p.A79T|POMT1_ENST00000372228.3_Missense_Mutation_p.A196T|POMT1_ENST00000402686.3_Missense_Mutation_p.A196T	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	196					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		GACAGGGGTCGCTTGTTCCTG	0.468000													50	84					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1976605	1976605	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1976605G>A	ENST00000382895.3	+	21	3819	c.3388G>A	c.(3388-3390)Gct>Act	p.A1130T	WHSC1_ENST00000508803.1_Missense_Mutation_p.A1130T|WHSC1_ENST00000382891.5_Missense_Mutation_p.A1130T|WHSC1_ENST00000382892.2_Missense_Mutation_p.A1130T|WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Missense_Mutation_p.A478T	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	1130	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TATAATAGACGCTGGCCCCAA	0.448000			T	IGH@	MM								6	72					0	0	1	0	0
SPATA31D5P	0	broad.mit.edu	37	9	84533090	84533090	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:84533090G>A	ENST00000527857.1	+	0	3112					NR_026851.1																						GTGCCTCCACGCCCCTTAGAA	0.463000													9	14					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55381397	55381397	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:55381397G>A	ENST00000398661.2	-	5	523	c.392C>T	c.(391-393)gCt>gTt	p.A131V	HMGCLL1_ENST00000508459.1_Intron|HMGCLL1_ENST00000370850.2_Intron|HMGCLL1_ENST00000308161.4_Intron|HMGCLL1_ENST00000274901.4_Missense_Mutation_p.A101V|HMGCLL1_ENST00000428842.1_Intron	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	131							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGTGTGATCAGCCATCTTAAA	0.358000													19	42					0	0	1	0	0
PAQR4	124222	broad.mit.edu	37	16	3021331	3021331	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3021331C>T	ENST00000318782.8	+	2	770	c.340C>T	c.(340-342)Cgg>Tgg	p.R114W	PAQR4_ENST00000574988.1_Missense_Mutation_p.R47W|PAQR4_ENST00000576565.1_Missense_Mutation_p.R47W|PKMYT1_ENST00000431515.2_Intron|PAQR4_ENST00000293978.8_Missense_Mutation_p.R75W|PAQR4_ENST00000572687.1_Intron	NM_152341.3	NP_689554.2	Q8N4S7	PAQR4_HUMAN	progestin and adipoQ receptor family member IV	114						integral to membrane	receptor activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	8						TGTGTACGCCCGGCTCCTCGC	0.652000													24	46					0	0	1	0	0
KCTD5	54442	broad.mit.edu	37	16	2752452	2752452	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2752452G>A	ENST00000564195.1	+	4	565	c.556G>A	c.(556-558)Ggc>Agc	p.G186S	KCTD5_ENST00000301738.4_Silent_p.T216T			Q9NXV2	KCTD5_HUMAN	potassium channel tetramerization domain containing 5	0					interspecies interaction between organisms	cytosol|nucleus|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			haematopoietic_and_lymphoid_tissue(1)|lung(1)	2						CGTACGGTACGGCCAGCGAGC	0.622000													6	29					0	0	1	0	0
LIMK2	3985	broad.mit.edu	37	22	31662048	31662048	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31662048A>G	ENST00000331728.4	+	8	1085	c.971A>G	c.(970-972)cAg>cGg	p.Q324R	LIMK2_ENST00000406516.1_Missense_Mutation_p.Q246R|LIMK2_ENST00000444929.2_Missense_Mutation_p.Q78R|LIMK2_ENST00000333611.4_Missense_Mutation_p.Q303R|LIMK2_ENST00000340552.4_Missense_Mutation_p.Q303R	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	324						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						TATTCACAGCAGATCTTCCGG	0.577000													3	49					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13361408	13361408	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:13361408T>C	ENST00000254508.5	-	37	5320	c.5238A>G	c.(5236-5238)acA>acG	p.T1746T		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1746					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CGACCGTGTATGTGATGAAGC	0.617000													15	28					0	0	1	0	0
PSMB2	5690	broad.mit.edu	37	1	36101917	36101917	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:36101917G>A	ENST00000373237.3	-	2	619	c.208C>T	c.(208-210)Cga>Tga	p.R70*		NM_002794.4	NP_002785.1	P49721	PSB2_HUMAN	proteasome (prosome, macropain) subunit, beta type, 2	70					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			endometrium(1)|large_intestine(2)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)			Bortezomib(DB00188)	CCACCATTTCGCATCTTATAA	0.388000													21	37					0	0	1	0	0
ZP3	7784	broad.mit.edu	37	7	76054468	76054468	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:76054468G>A	ENST00000336517.4	+	2	380	c.34G>A	c.(34-36)Ggg>Agg	p.G12R	ZP3_ENST00000394857.3_Missense_Mutation_p.G63R	NM_007155.5	NP_009086.4	P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 (sperm receptor)	63					binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7						TTTTGGCACCGGGAAGCTCAT	0.587000													9	12					0	0	1	0	0
DKK1	22943	broad.mit.edu	37	10	54074735	54074735	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:54074735G>A	ENST00000373970.3	+	2	435	c.296G>A	c.(295-297)aGt>aAt	p.S99N	DKK1_ENST00000467359.1_3'UTR	NM_012242.2	NP_036374.1	O94907	DKK1_HUMAN	dickkopf WNT signaling pathway inhibitor 1	99	DKK-type Cys-1.				negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			kidney(2)|large_intestine(4)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	16						TACTGCGCTAGTCCCACCCGC	0.642000											OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	19					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78362427	78362427	+	Missense_Mutation	SNP	G	G	A	rs34739021		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:78362427G>A	ENST00000397909.2	+	5	789	c.616G>A	c.(616-618)Gct>Act	p.A206T	NAV3_ENST00000266692.7_Missense_Mutation_p.A206T|NAV3_ENST00000536525.2_Missense_Mutation_p.A206T|NAV3_ENST00000228327.6_Missense_Mutation_p.A206T			Q8IVL0	NAV3_HUMAN	neuron navigator 3	206						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AGTTACTCACGCTTCCCCTCC	0.473000										HNSCC(70;0.22)			25	22					0	0	1	0	0
RPL35A	6165	broad.mit.edu	37	3	197678115	197678115	+	Missense_Mutation	SNP	G	G	A	rs116840808		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:197678115G>A	ENST00000464167.1	+	3	364	c.97G>A	c.(97-99)Gtt>Att	p.V33I	RPL35A_ENST00000448864.1_Missense_Mutation_p.V33I|RPL35A_ENST00000329092.8_3'UTR|IQCG_ENST00000480302.1_Intron|IQCG_ENST00000265239.6_Intron	NM_000996.2	NP_000987.2	P18077	RL35A_HUMAN	ribosomal protein L35a	33			V -> I (in DBA5; may result in aberrant splicing).		endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome|tRNA binding			lung(1)|prostate(1)|urinary_tract(1)	3	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;1.04e-23)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.182)		AATTGAAGGTGTTTACGCCCG	0.428000													23	40					0	0	1	0	0
CLCN7	1186	broad.mit.edu	37	16	1498404	1498404	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1498404C>T	ENST00000382745.4	-	21	2570	c.1965G>A	c.(1963-1965)gcG>gcA	p.A655A	CLCN7_ENST00000262318.8_Silent_p.A631A|CLCN7_ENST00000448525.1_Silent_p.A631A	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	655	CBS 1.					integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				TGTGATTGGACGCCGTGTCGC	0.647000													17	15					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123310804	123310804	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:123310804C>A	ENST00000358487.5	-	5	896	c.624_splice	c.e5+1	p.K208_splice	FGFR2_ENST00000369060.4_Splice_Site_p.K208_splice|FGFR2_ENST00000356226.4_Splice_Site_p.K93_splice|FGFR2_ENST00000359354.2_Splice_Site_p.K208_splice|FGFR2_ENST00000457416.2_Splice_Site_p.K208_splice|FGFR2_ENST00000369061.4_Splice_Site_p.K208_splice|FGFR2_ENST00000360144.3_Splice_Site_p.K119_splice|FGFR2_ENST00000369059.1_Splice_Site_p.K93_splice|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000357555.5_Splice_Site_p.K119_splice|FGFR2_ENST00000369056.1_Splice_Site_p.K208_splice|FGFR2_ENST00000351936.6_Splice_Site_p.K208_splice|FGFR2_ENST00000346997.2_Splice_Site_p.K208_splice	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	208	Ig-like C2-type 2.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	TTAATTCTACCTTGTAGCCTC	0.448000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				28	53					5.45727e-16	5.98296e-16	1	1	0
KRT76	51350	broad.mit.edu	37	12	53170909	53170909	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53170909C>T	ENST00000332411.2	-	1	220	c.167G>A	c.(166-168)cGc>cAc	p.R56H		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	56	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GTAGAGGCTGCGACTGCCAAA	0.672000													31	47					0	0	1	0	0
FAM129A	116496	broad.mit.edu	37	1	184775093	184775093	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:184775093A>G	ENST00000367511.3	-	11	1626	c.1433T>C	c.(1432-1434)cTc>cCc	p.L478P	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	478					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						TAAGACTCGGAGTTTAACCTT	0.428000											OREG0014050	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	24					0	0	1	0	0
NPNT	255743	broad.mit.edu	37	4	106888398	106888398	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:106888398C>T	ENST00000379987.2	+	11	1615	c.1399C>T	c.(1399-1401)Cgc>Tgc	p.R467C	NPNT_ENST00000506666.1_Missense_Mutation_p.R468C|NPNT_ENST00000453617.2_Missense_Mutation_p.R484C|NPNT_ENST00000514622.1_Missense_Mutation_p.R438C|NPNT_ENST00000427316.2_Missense_Mutation_p.R497C|NPNT_ENST00000305572.8_Missense_Mutation_p.R438C	NM_001033047.2	NP_001028219.1	Q6UXI9	NPNT_HUMAN	nephronectin	467	MAM.				cell differentiation	membrane	calcium ion binding	p.R467C(1)		kidney(5)|large_intestine(2)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	21		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		AAAAGCTGCACGCTTGGTGCT	0.572000													6	23					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23641340	23641340	+	Missense_Mutation	SNP	G	G	A	rs141458731	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:23641340G>A	ENST00000261584.4	-	5	2287	c.2135C>T	c.(2134-2136)gCg>gTg	p.A712V		NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	712					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		ATCATCAGGCGCAACCGTATT	0.458000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					44	74					0	0	1	0	0
TST	7263	broad.mit.edu	37	22	37407119	37407119	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37407119G>T	ENST00000403892.3	-	2	1577	c.843C>A	c.(841-843)cgC>cgA	p.R281R	TST_ENST00000249042.3_Silent_p.R281R	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	281	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						GGGGGGCCCGGCGAAACCACT	0.642000													18	28					6.49762e-13	7.04361e-13	1	1	0
ATR	545	broad.mit.edu	37	3	142180885	142180885	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:142180885T>C	ENST00000350721.4	-	42	7210	c.7089A>G	c.(7087-7089)cgA>cgG	p.R2363R	ATR_ENST00000383101.3_Silent_p.R2299R	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2363	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						CTGCATATGTTCGAATATGAA	0.313000								Other conserved DNA damage response genes					44	95					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10219625	10219625	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:10219625G>C	ENST00000256458.4	+	2	288	c.198G>C	c.(196-198)atG>atC	p.M66I		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	66	Death.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						GGTGGGGCATGCGGCAGGCCA	0.632000													18	40					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120980048	120980048	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:120980048C>T	ENST00000392793.1	+	4	598	c.327C>T	c.(325-327)ggC>ggT	p.G109G	TECTA_ENST00000264037.2_Silent_p.G109G			O75443	TECTA_HUMAN	tectorin alpha	109	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GAATTCGAGGCGAGATCTATT	0.507000													16	30					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36365764	36365764	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36365764G>A	ENST00000221891.4	+	10	1529	c.1337G>A	c.(1336-1338)cGc>cAc	p.R446H	APLP1_ENST00000537454.2_Missense_Mutation_p.R407H|APLP1_ENST00000586861.1_Missense_Mutation_p.R440H|APLP1_ENST00000589298.2_3'UTR	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	446	Collagen-binding (By similarity).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAGCAGATGCGCTTCCAGGTG	0.622000													4	15					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160035216	160035216	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:160035216C>T	ENST00000263635.6	+	14	2289	c.2052C>T	c.(2050-2052)gcC>gcT	p.A684A	TANC1_ENST00000454300.1_Silent_p.A578A	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	684						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						ATGGCAAGGCCGATGCCACAC	0.587000													7	31					0	0	1	0	0
CSRP3	8048	broad.mit.edu	37	11	19213898	19213898	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:19213898G>A	ENST00000533783.1	-	3	338	c.98C>T	c.(97-99)aCg>aTg	p.T33M	CSRP3_ENST00000265968.3_Missense_Mutation_p.T33M	NM_003476.4	NP_003467.1	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3 (cardiac LIM protein)	33	LIM zinc-binding 1.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10						GTGGAAACACGTCTTGTGGAA	0.512000													16	38					0	0	1	0	0
RAB15	376267	broad.mit.edu	37	14	65417801	65417801	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:65417801G>A	ENST00000533601.2	-	4	652	c.315C>T	c.(313-315)gaC>gaT	p.D105D	RAB15_ENST00000436278.2_Silent_p.D59D|CHURC1-FNTB_ENST00000542227.1_Intron|RAB15_ENST00000426039.3_Silent_p.D59D|CHURC1-FNTB_ENST00000447296.2_Intron|RAB15_ENST00000267512.5_Silent_p.D105D			P59190	RAB15_HUMAN	RAB15, member RAS oncogene family	105					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	8				all cancers(60;0.00136)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.0102)		CCTCATCCACGTCACTGACCC	0.537000													31	39					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945789	72945789	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:72945789C>T	ENST00000311131.2	+	3	1052	c.585C>T	c.(583-585)ttC>ttT	p.F195F	P2RY2_ENST00000393597.2_Silent_p.F195F|P2RY2_ENST00000393596.2_Silent_p.F195F	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	195					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	TCAGCCGCTTCGTGGCCTACA	0.652000													11	15					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181684513	181684513	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:181684513C>T	ENST00000526775.1	+	9	1376	c.1211C>T	c.(1210-1212)aCa>aTa	p.T404I	CACNA1E_ENST00000367570.1_Missense_Mutation_p.T404I|CACNA1E_ENST00000360108.3_Missense_Mutation_p.T404I|CACNA1E_ENST00000367567.4_Missense_Mutation_p.T11I|CACNA1E_ENST00000367573.2_Missense_Mutation_p.T404I|CACNA1E_ENST00000357570.5_Missense_Mutation_p.T355I|CACNA1E_ENST00000358338.5_Missense_Mutation_p.T355I	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	404					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AATGCTGGAACATCCGCCTTA	0.378000													8	8					0	0	1	0	0
KIRREL2	84063	broad.mit.edu	37	19	36348250	36348250	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36348250C>T	ENST00000360202.5	+	2	263	c.65C>T	c.(64-66)cCg>cTg	p.P22L	NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000347900.6_Intron|KIRREL2_ENST00000592409.1_Missense_Mutation_p.P22L|KIRREL2_ENST00000262625.7_Missense_Mutation_p.P22L|KIRREL2_ENST00000586102.2_Missense_Mutation_p.P22L	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	22					cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCCTAGGCCCGTCGCCCCAT	0.662000													34	46					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112622525	112622525	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112622525G>A	ENST00000550722.1	-	61	10202	c.9807C>T	c.(9805-9807)ggC>ggT	p.G3269G	HECTD4_ENST00000377560.5_Silent_p.G3243G|HECTD4_ENST00000430131.2_Silent_p.G2993G	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGCGGATGGCGCCTCTGACTA	0.652000													50	52					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138749722	138749722	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:138749722G>A	ENST00000242351.5	-	8	2212	c.1896C>T	c.(1894-1896)aaC>aaT	p.N632N	ZC3HAV1_ENST00000464606.1_Silent_p.N754N|ZC3HAV1_ENST00000471652.1_Silent_p.N632N	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	632	WWE.				response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						AAGAGTCGACGTTTGAATTTT	0.413000													28	21					0	0	1	0	0
FAM5C	0	broad.mit.edu	37	1	190068210	190068210	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:190068210G>A	ENST00000367462.3	-	8	1470	c.1239C>T	c.(1237-1239)aaC>aaT	p.N413N	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Silent_p.N311N	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		413						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CTAGGAGGCCGTTCTCATTGC	0.493000													6	19					0	0	1	0	0
GCNT3	9245	broad.mit.edu	37	15	59910606	59910606	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:59910606T>C	ENST00000396065.1	+	3	617	c.169T>C	c.(169-171)Tat>Cat	p.Y57H	GCNT3_ENST00000560585.1_Missense_Mutation_p.Y57H	NM_004751.2	NP_004742.1	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin type	57					protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GAATATCTTGTATAATTTCCT	0.473000													12	64					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43597841	43597841	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:43597841C>T	ENST00000355710.3	+	3	621	c.389C>T	c.(388-390)aCa>aTa	p.T130I	RET_ENST00000340058.5_Missense_Mutation_p.T130I	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	130					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	CTGTCACCCACATCCCTTCGT	0.622000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				25	32					0	0	1	0	0
HMG20A	10363	broad.mit.edu	37	15	77770726	77770726	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:77770726C>T	ENST00000381714.3	+	9	1209	c.781C>T	c.(781-783)Cgc>Tgc	p.R261C	HMG20A_ENST00000336216.4_Missense_Mutation_p.R261C	NM_018200.2	NP_060670.1	Q9NP66	HM20A_HUMAN	high mobility group 20A	261					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.R261C(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						GGAGAGCATGCGCACAGCAGT	0.587000													8	20					0	0	1	0	0
METTL9	51108	broad.mit.edu	37	16	21666715	21666715	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:21666715G>A	ENST00000358154.3	+	5	1177	c.919G>A	c.(919-921)Gtt>Att	p.V307I	METTL9_ENST00000396014.4_Missense_Mutation_p.V306I	NM_001077180.1|NM_016025.3	NP_001070648.1|NP_057109.3	Q9H1A3	METL9_HUMAN	methyltransferase like 9	307										endometrium(1)|kidney(3)|large_intestine(1)|lung(1)|ovary(1)	7				GBM - Glioblastoma multiforme(48;0.0759)		TGACTACTACGTTCTGGATGA	0.473000													29	44					0	0	1	0	0
NUP88	4927	broad.mit.edu	37	17	5322726	5322726	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:5322726C>T	ENST00000573584.1	-	1	754	c.245G>A	c.(244-246)cGc>cAc	p.R82H		NM_002532.4	NP_002523.2	Q99567	NUP88_HUMAN	nucleoporin 88kDa	82					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			endometrium(4)|kidney(4)|large_intestine(4)|lung(3)	15						GCCCCGAAGGCGAACGACTAA	0.642000													9	33					0	0	1	0	0
GTPBP6	8225	broad.mit.edu	37	X	224096	224096	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:224096G>A	ENST00000326153.4	-	5	670	c.671C>T	c.(670-672)gCg>gTg	p.A224V				O43824	GTPB6_HUMAN	GTP binding protein 6 (putative)	453						intracellular	GTP binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(3)	7		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CAAAACCGCCGCATCGAGCTC	0.672000													19	7					0	0	1	0	0
DENND1B	163486	broad.mit.edu	37	1	197611872	197611872	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:197611872C>T	ENST00000235453.4	-	10	828	c.551G>A	c.(550-552)cGc>cAc	p.R184H	DENND1B_ENST00000400967.2_Missense_Mutation_p.R184H|DENND1B_ENST00000367396.3_Missense_Mutation_p.R214H			Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B	214	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			NS(2)|breast(2)|kidney(2)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	22						AATCACGATGCGCCTTTCATG	0.378000													22	35					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55277779	55277779	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55277779C>T	ENST00000358193.3	+	6	733	c.679C>T	c.(679-681)Cga>Tga	p.R227*	C1orf177_ENST00000371273.3_Nonsense_Mutation_p.R227*	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	227										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						ATATGTGGCACGATCCGTCGG	0.587000													11	36					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113496256	113496256	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:113496256G>T	ENST00000257600.3	+	1	762	c.259_splice	c.e1+1	p.G87_splice		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	87	WWE 1.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						CCAGGACACAGGTGAGCAGAC	0.612000													17	43					8.28177e-16	9.07663e-16	1	1	0
EDC4	23644	broad.mit.edu	37	16	67914539	67914539	+	Missense_Mutation	SNP	G	G	A	rs151306360		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67914539G>A	ENST00000358933.5	+	18	2416	c.2177G>A	c.(2176-2178)cGc>cAc	p.R726H		NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	726					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TCCCCTAGCCGCACTCGTTCC	0.622000													62	107					0	0	1	0	0
EPHB6	0	broad.mit.edu	37	7	142568000	142568000	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142568000C>T	ENST00000392957.2	+	18	3428	c.2641C>T	c.(2641-2643)Ccc>Tcc	p.P881S	EPHB6_ENST00000476059.1_3'UTR|EPHB6_ENST00000442129.1_Missense_Mutation_p.P881S|EPHB6_ENST00000411471.2_Missense_Mutation_p.P604S	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	881	Poly-Pro.|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GTTCCGGCTGCCCCCGCCTCC	0.537000													65	103					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128304058	128304058	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:128304058A>G	ENST00000368227.3	-	25	3872	c.3506T>C	c.(3505-3507)gTc>gCc	p.V1169A	PTPRK_ENST00000532331.1_Missense_Mutation_p.V1174A|PTPRK_ENST00000368207.3_Missense_Mutation_p.V1184A|PTPRK_ENST00000368226.4_Missense_Mutation_p.V1152A|PTPRK_ENST00000368215.3_Missense_Mutation_p.V1151A|PTPRK_ENST00000368213.5_Missense_Mutation_p.V1158A|PTPRK_ENST00000368210.3_Missense_Mutation_p.V1170A			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1151					cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		AAATTCACAGACAGGTATGGC	0.323000													25	50					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192932	152192932	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:152192932G>T	ENST00000368801.2	-	3	1248	c.1173C>A	c.(1171-1173)ggC>ggA	p.G391G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	391					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGAGCTGGAGCCATGTTGGC	0.577000													26	56					3.01185e-09	3.19065e-09	1	1	0
SLC45A1	50651	broad.mit.edu	37	1	8386059	8386059	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:8386059C>T	ENST00000471889.1	+	4	1057	c.672C>T	c.(670-672)ccC>ccT	p.P224P	SLC45A1_ENST00000289877.8_Silent_p.P224P|SLC45A1_ENST00000377479.2_Silent_p.P258P			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	224					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		TGTGCAGCCCCGCAGACCAGG	0.662000													13	34					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7695266	7695266	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7695266C>T	ENST00000572933.1	+	45	8392	c.6932C>T	c.(6931-6933)aCc>aTc	p.T2311I	DNAH2_ENST00000389173.2_Missense_Mutation_p.T2311I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2311					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AACTATGTCACCATGGTAGAG	0.537000													44	83					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55903572	55903572	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:55903572C>T	ENST00000521992.1	-	5	734	c.589G>A	c.(589-591)Gtg>Atg	p.V197M	CES5A_ENST00000290567.9_Missense_Mutation_p.V168M|CES5A_ENST00000520435.1_Missense_Mutation_p.V138M|CES5A_ENST00000518005.1_Missense_Mutation_p.V62M|CES5A_ENST00000541580.1_Intron|CES5A_ENST00000319165.9_Missense_Mutation_p.V168M	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	168						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						ACAACCAGCACGTCCTCATAG	0.562000													7	40					0	0	1	0	0
FBXO43	286151	broad.mit.edu	37	8	101146206	101146206	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:101146206G>A	ENST00000428847.2	-	5	2267	c.1951C>T	c.(1951-1953)Cca>Tca	p.P651S		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	651					meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TTCTTATATGGCTGGTACTTA	0.443000													33	53					0	0	1	0	0
JMJD7-PLA2G4B	0	broad.mit.edu	37	15	42138157	42138157	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42138157G>A	ENST00000382448.4	+	21	2214	c.2205G>A	c.(2203-2205)ctG>ctA	p.L735L	PLA2G4B_ENST00000452633.1_Silent_p.L504L|JMJD7-PLA2G4B_ENST00000342159.4_Silent_p.L735L|JMJD7-PLA2G4B_ENST00000458483.1_Silent_p.L504L	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		504	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						GGAGCAACCTGTATGCAGCCA	0.612000													26	32					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34037247	34037247	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:34037247G>A	ENST00000373381.4	-	51	8018	c.7842C>T	c.(7840-7842)ttC>ttT	p.F2614F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2616	Sushi 16.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCTGGGCCTGGAACTGATACT	0.527000													29	35					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170321765	170321765	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:170321765G>A	ENST00000439128.2	-	32	4177	c.3537C>T	c.(3535-3537)tgC>tgT	p.C1179C	NEK1_ENST00000511633.1_Silent_p.C1163C|NEK1_ENST00000512193.1_Silent_p.C1110C|NEK1_ENST00000510533.1_Silent_p.C1135C|NEK1_ENST00000507142.1_Silent_p.C1207C	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	1179					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.C1207C(4)		NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		AGACACTATCGCATTCACATT	0.318000													7	10					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271436	59271436	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:59271436C>A	ENST00000313253.1	+	1	388	c.388C>A	c.(388-390)Ctg>Atg	p.L130M		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						CTCCAAGCCCCTGCACTATGT	0.522000													41	54					1.62957e-23	1.81649e-23	1	1	0
LRP1	4035	broad.mit.edu	37	12	57599196	57599196	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57599196C>T	ENST00000243077.3	+	74	11864	c.11398C>T	c.(11398-11400)Cgc>Tgc	p.R3800C		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3800	EGF-like 14.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACGCTGCGTGCGCACCGAGAA	0.677000													5	11					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71909728	71909728	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:71909728G>A	ENST00000258104.3	+	54	6402	c.6125G>A	c.(6124-6126)cGt>cAt	p.R2042H	DYSF_ENST00000429174.2_Missense_Mutation_p.R2063H|DYSF_ENST00000410020.3_Missense_Mutation_p.R2081H|DYSF_ENST00000409762.1_Missense_Mutation_p.R2059H|DYSF_ENST00000409744.1_Missense_Mutation_p.R2050H|DYSF_ENST00000409651.1_Missense_Mutation_p.R2074H|DYSF_ENST00000409366.1_Missense_Mutation_p.R2064H|DYSF_ENST00000394120.2_Missense_Mutation_p.R2043H|DYSF_ENST00000413539.2_Missense_Mutation_p.R2073H|DYSF_ENST00000409582.3_Missense_Mutation_p.R2080H|DYSF_ENST00000410041.1_Missense_Mutation_p.R2060H|DYSF_ENST00000479049.2_3'UTR	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	2042			R -> C (in MMD1, LGMD2B and proximodistal myopathy).			cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CTGTGGCGGCGTTTCCGGTGG	0.582000													28	38					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16918888	16918888	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16918888G>A	ENST00000524140.2	+	18	4646	c.4228G>A	c.(4228-4230)Gcc>Acc	p.A1410T	NWD1_ENST00000339803.6_Missense_Mutation_p.A1275T|NWD1_ENST00000523826.1_Missense_Mutation_p.A1204T|NWD1_ENST00000552788.1_Missense_Mutation_p.A1410T|NWD1_ENST00000379808.3_Missense_Mutation_p.A1410T|NWD1_ENST00000549814.1_Missense_Mutation_p.A1368T	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1410							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GTCTGAGGATGCCCTGCTGTG	0.602000													27	45					0	0	1	0	0
CHST2	9435	broad.mit.edu	37	3	142840257	142840257	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:142840257T>C	ENST00000309575.3	+	2	1983	c.599T>C	c.(598-600)gTa>gCa	p.V200A		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	200					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						GTGTGGCATGTATGGCAAAAA	0.582000													16	54					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98354040	98354040	+	Missense_Mutation	SNP	G	G	A	rs137853201		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:98354040G>A	ENST00000264972.5	+	11	1609	c.1394G>A	c.(1393-1395)cGc>cAc	p.R465H	ZAP70_ENST00000463643.1_3'UTR|ZAP70_ENST00000442208.1_Missense_Mutation_p.R339H|ZAP70_ENST00000451498.2_Missense_Mutation_p.R158H	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	465	Protein kinase.		R -> C (in STD).|R -> H (in STD).		immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						CTGGCGGCCCGCAACGTCCTG	0.587000													10	12					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87757933	87757933	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:87757933G>A	ENST00000398204.4	+	9	1018	c.695G>A	c.(694-696)cGt>cAt	p.R232H	ADAM22_ENST00000315984.7_Missense_Mutation_p.R232H|ADAM22_ENST00000398201.4_Missense_Mutation_p.R232H|ADAM22_ENST00000439864.1_Missense_Mutation_p.R232H|ADAM22_ENST00000265727.7_Missense_Mutation_p.R232H|ADAM22_ENST00000398209.3_Missense_Mutation_p.R232H	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	232					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CGATATCCTCGTAATGTAGAA	0.393000													28	51					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183508767	183508767	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:183508767C>T	ENST00000305135.5	+	21	3291	c.3097_splice	c.e21+1	p.S1032_splice		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1032					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCACAGTATCCGGTGAGTTGC	0.522000													7	56					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1976680	1976680	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1976680G>A	ENST00000382895.3	+	21	3894	c.3463G>A	c.(3463-3465)Gtg>Atg	p.V1155M	WHSC1_ENST00000508803.1_Missense_Mutation_p.V1155M|WHSC1_ENST00000382891.5_Missense_Mutation_p.V1155M|WHSC1_ENST00000382892.2_Missense_Mutation_p.V1155M|WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Missense_Mutation_p.V503M	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	1155	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CAAGTGGACAGTGAATGGGGA	0.557000			T	IGH@	MM								15	81					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116631818	116631818	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:116631818C>T	ENST00000395715.3	-	3	1084	c.507G>A	c.(505-507)atG>atA	p.M169I	TRPS1_ENST00000220888.5_Missense_Mutation_p.M156I|TRPS1_ENST00000519674.1_Missense_Mutation_p.M156I|TRPS1_ENST00000520276.1_Missense_Mutation_p.M160I|TRPS1_ENST00000519076.1_Missense_Mutation_p.M110I	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	156					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CCTTTGGTGACATCTTCTGAT	0.522000									Langer-Giedion syndrome				25	60					0	0	1	0	0
ELP3	55140	broad.mit.edu	37	8	28017844	28017844	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:28017844A>G	ENST00000256398.8	+	13	1733	c.1356A>G	c.(1354-1356)cgA>cgG	p.R452R	ELP3_ENST00000524103.1_Silent_p.R380R|ELP3_ENST00000521015.1_Silent_p.R438R|ELP3_ENST00000380353.4_Silent_p.R360R|ELP3_ENST00000537665.1_Silent_p.R333R|ELP3_ENST00000542181.1_Silent_p.R323R	NM_018091.5	NP_060561.3	Q9H9T3	ELP3_HUMAN	elongator acetyltransferase complex subunit 3	452	N-acetyltransferase.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding			kidney(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		GCCTCCTACGATTACGCAAGT	0.458000													23	25					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71816734	71816734	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:71816734G>T	ENST00000258104.3	+	31	3637	c.3360G>T	c.(3358-3360)atG>atT	p.M1120I	DYSF_ENST00000429174.2_Missense_Mutation_p.M1120I|DYSF_ENST00000410020.3_Missense_Mutation_p.M1138I|DYSF_ENST00000409762.1_Missense_Mutation_p.M1137I|DYSF_ENST00000409744.1_Missense_Mutation_p.M1107I|DYSF_ENST00000409651.1_Missense_Mutation_p.M1152I|DYSF_ENST00000409366.1_Missense_Mutation_p.M1121I|DYSF_ENST00000394120.2_Missense_Mutation_p.M1121I|DYSF_ENST00000413539.2_Missense_Mutation_p.M1151I|DYSF_ENST00000409582.3_Missense_Mutation_p.M1137I|DYSF_ENST00000410041.1_Missense_Mutation_p.M1138I|DYSF_ENST00000479049.2_3'UTR	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1120						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GCGGCGTGATGGATGACAAGA	0.572000													51	52					4.25531e-23	4.74031e-23	1	1	0
FAM65C	140876	broad.mit.edu	37	20	49225025	49225025	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:49225025G>A	ENST00000327979.2	-	11	1256	c.845C>T	c.(844-846)aCg>aTg	p.T282M	FAM65C_ENST00000535356.1_Missense_Mutation_p.T286M|FAM65C_ENST00000045083.2_Missense_Mutation_p.T282M			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	282										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GATGTCACACGTCACTGCACC	0.657000													32	38					0	0	1	0	0
RBM25	58517	broad.mit.edu	37	14	73572703	73572703	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:73572703C>T	ENST00000261973.7	+	11	1576	c.1291C>T	c.(1291-1293)Cgg>Tgg	p.R431W	RBM25_ENST00000527432.1_Missense_Mutation_p.R431W	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	431	Arg-rich.|Glu-rich.|Necessary for nuclear speckle localization.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		agaCAAAAAACGGGACCGAGA	0.458000													20	23					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118701610	118701610	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:118701610C>T	ENST00000376300.2	-	18	1540	c.1403G>A	c.(1402-1404)cGt>cAt	p.R468H	CCDC93_ENST00000319432.5_Missense_Mutation_p.R467H	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	468										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						CTGTAGTAAACGTATCTTGTA	0.323000													17	32					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152807867	152807867	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:152807867G>A	ENST00000370186.1	+	5	1077	c.751G>A	c.(751-753)Gtg>Atg	p.V251M	ATP2B3_ENST00000370181.2_Missense_Mutation_p.V251M|ATP2B3_ENST00000263519.4_Missense_Mutation_p.V251M|ATP2B3_ENST00000393842.1_Missense_Mutation_p.V251M|ATP2B3_ENST00000349466.2_Missense_Mutation_p.V251M|ATP2B3_ENST00000359149.3_Missense_Mutation_p.V251M			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	251					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTCTGACCACGTGCGCAAGTC	0.662000													7	2					0	0	1	0	0
NARF	26502	broad.mit.edu	37	17	80417933	80417933	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80417933C>T	ENST00000309794.10	+	2	291	c.93C>T	c.(91-93)gcC>gcT	p.A31A	NARF_ENST00000581743.1_3'UTR|NARF_ENST00000412079.2_5'UTR|NARF_ENST00000390006.4_5'UTR|NARF_ENST00000457415.3_Silent_p.A31A|NARF_ENST00000345415.7_Silent_p.A31A	NM_012336.3|NM_031968.2	NP_036468.1|NP_114174.1	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor	31						lamin filament	lamin binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			CGAGTCCAGCCCAGGAAAATG	0.423000													20	21					0	0	1	0	0
EXOG	9941	broad.mit.edu	37	3	38545115	38545115	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38545115G>A	ENST00000287675.5	+	4	559	c.463G>A	c.(463-465)Gct>Act	p.A155T	EXOG_ENST00000422077.2_Missense_Mutation_p.A105T|EXOG_ENST00000358249.2_Missense_Mutation_p.A15T	NM_005107.3	NP_005098.2	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	155						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding			central_nervous_system(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	17						GAAAGCCATGGCTGAAACCTT	0.318000													25	46					0	0	1	0	0
HAUS3	79441	broad.mit.edu	37	4	2240481	2240481	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2240481T>A	ENST00000243706.4	-	3	1428	c.1199A>T	c.(1198-1200)gAc>gTc	p.D400V	HAUS3_ENST00000506763.1_Missense_Mutation_p.D400V|POLN_ENST00000511885.2_Intron|HAUS3_ENST00000443786.2_Missense_Mutation_p.D400V|POLN_ENST00000515357.1_Intron	NM_024511.5	NP_078787.2	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	400					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						ACGATATATGTCCCGATGCTT	0.303000													21	23					0	0	1	0	0
SMOX	54498	broad.mit.edu	37	20	4163429	4163429	+	Missense_Mutation	SNP	G	G	A	rs150061281		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:4163429G>A	ENST00000305958.4	+	5	1528	c.1303G>A	c.(1303-1305)Gtc>Atc	p.V435I	SMOX_ENST00000346595.2_Intron|SMOX_ENST00000379460.2_Missense_Mutation_p.V435I|SMOX_ENST00000278795.3_Missense_Mutation_p.V382I|SMOX_ENST00000339123.6_Missense_Mutation_p.V382I	NM_175839.1	NP_787033.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	435					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	GGAGGCCCTCGTCATGGAGAA	0.637000													6	23					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135204232	135204232	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:135204232G>A	ENST00000372169.2	-	10	2935	c.2753C>T	c.(2752-2754)aCt>aTt	p.T918I	SETX_ENST00000224140.5_Missense_Mutation_p.T918I|SETX_ENST00000393220.1_Missense_Mutation_p.T918I			Q7Z333	SETX_HUMAN	senataxin	918					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TTCAGGTACAGTCATAAGATC	0.368000													25	44					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6266854	6266854	+	Missense_Mutation	SNP	C	C	T	rs140712764	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:6266854C>T	ENST00000264870.3	-	4	773	c.508G>A	c.(508-510)Gta>Ata	p.V170I		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	170					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GTTCGAAGTACGCCATAGGGA	0.458000													13	91					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25257937	25257937	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:25257937C>T	ENST00000216962.4	+	7	940	c.830C>T	c.(829-831)tCc>tTc	p.S277F		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	277					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	GAGAACATCTCCAGGGTCCTG	0.572000													13	50					0	0	1	0	0
POR	5447	broad.mit.edu	37	7	75609690	75609690	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:75609690G>A	ENST00000394893.1	+	5	420	c.400G>A	c.(400-402)Gcc>Acc	p.A134T	POR_ENST00000419840.1_5'UTR|POR_ENST00000461988.1_Missense_Mutation_p.A134T|POR_ENST00000545601.1_5'UTR			P16435	NCPR_HUMAN	P450 (cytochrome) oxidoreductase	131	Flavodoxin-like.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|lung(3)|ovary(1)	9					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	GATCGACAACGCCCTGGTGGT	0.617000													23	23					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5397140	5397140	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:5397140C>T	ENST00000341928.2	-	18	3098	c.2758G>A	c.(2758-2760)Gcc>Acc	p.A920T	EPB41L3_ENST00000542146.1_Missense_Mutation_p.A225T|EPB41L3_ENST00000400111.3_Missense_Mutation_p.A698T|EPB41L3_ENST00000427684.2_Missense_Mutation_p.A217T|EPB41L3_ENST00000544123.1_Missense_Mutation_p.A751T|EPB41L3_ENST00000342933.3_Missense_Mutation_p.A920T|EPB41L3_ENST00000540638.2_Missense_Mutation_p.A698T|EPB41L3_ENST00000542652.2_5'UTR	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	920	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						GAAGCAGCGGCTGTCTCTTCC	0.512000													32	45					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11447030	11447030	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:11447030C>T	ENST00000423059.3	-	20	4070	c.3819G>A	c.(3817-3819)tgG>tgA	p.W1273*	AC004160.4_ENST00000425837.1_RNA|AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1273	TSP type-1 12.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TGTTCATCTGCCAGTTCTTCT	0.478000										HNSCC(18;0.044)			5	6					0	0	1	0	0
WNT7A	7476	broad.mit.edu	37	3	13896129	13896129	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:13896129C>T	ENST00000285018.4	-	3	774	c.470G>A	c.(469-471)cGc>cAc	p.R157H		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	157					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						GATGCCGTAGCGGATGTCGGC	0.607000													4	102					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118970010	118970010	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:118970010G>A	ENST00000515256.1	+	3	739	c.567G>A	c.(565-567)ggG>ggA	p.G189G				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	189						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						AGCCCAGTGGGGAGGAGAAAG	0.562000													19	22					0	0	1	0	0
BEND7	222389	broad.mit.edu	37	10	13523090	13523090	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:13523090A>C	ENST00000341083.3	-	6	1012	c.716T>G	c.(715-717)tTt>tGt	p.F239C	BEND7_ENST00000378605.3_Missense_Mutation_p.F252C|BEND7_ENST00000396900.2_Missense_Mutation_p.F291C|BEND7_ENST00000396898.2_Missense_Mutation_p.F304C	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	291							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						TTTAGGCATAAACACGTCAAA	0.398000													17	60					0	0	1	0	0
CLMP	79827	broad.mit.edu	37	11	122944221	122944221	+	Silent	SNP	G	G	A	rs138871742		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:122944221G>A	ENST00000448775.2	-	7	1423	c.1083C>T	c.(1081-1083)agC>agT	p.S361S	CLMP_ENST00000530371.1_5'UTR	NM_024769.2	NP_079045.1	Q9H6B4	CLMP_HUMAN	CXADR-like membrane protein	361						integral to membrane|tight junction				endometrium(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	14						TGGGGATCATGCTGGGTGTGG	0.532000													46	90					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98351716	98351716	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:98351716G>T	ENST00000264972.5	+	10	1301	c.1086G>T	c.(1084-1086)aaG>aaT	p.K362N	ZAP70_ENST00000463643.1_3'UTR|ZAP70_ENST00000442208.1_Missense_Mutation_p.K236N|ZAP70_ENST00000451498.2_Missense_Mutation_p.K55N	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	362	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						CGGGCAGGAAGCAGATCGACG	0.657000													9	35					1.12685e-05	1.16601e-05	1	1	0
EPS15L1	58513	broad.mit.edu	37	19	16514562	16514562	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16514562C>T	ENST00000602009.1	-	9	2041	c.1146G>A	c.(1144-1146)acG>acA	p.T382T	EPS15L1_ENST00000597937.1_Silent_p.T536T|EPS15L1_ENST00000594975.1_Silent_p.T536T|EPS15L1_ENST00000535753.2_Silent_p.T536T|EPS15L1_ENST00000248070.6_Silent_p.T536T|EPS15L1_ENST00000455140.2_Silent_p.T536T			Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	536					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding	p.T536T(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						TTTCGTCTTGCGTTGACTTCA	0.587000													30	51					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222294822	222294822	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:222294822C>T	ENST00000281821.2	-	15	2587	c.2546G>A	c.(2545-2547)tGc>tAc	p.C849Y	EPHA4_ENST00000409938.1_Missense_Mutation_p.C849Y|EPHA4_ENST00000409854.1_Missense_Mutation_p.C849Y|EPHA4_ENST00000392071.4_Missense_Mutation_p.C798Y	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	849	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CGCAATGGGGCAGTCCATTGG	0.512000													25	40					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38791805	38791805	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:38791805G>A	ENST00000310301.4	-	22	1951	c.1897C>T	c.(1897-1899)Cga>Tga	p.R633*	VPS41_ENST00000395969.2_Nonsense_Mutation_p.R608*	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	633					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						GTACTGTCTCGGAGAAAGGGA	0.433000													47	60					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23929388	23929388	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:23929388C>T	ENST00000382298.3	-	8	1951	c.1363G>A	c.(1363-1365)Gaa>Aaa	p.E455K	SACS_ENST00000402364.1_5'UTR|SACS_ENST00000382292.3_Missense_Mutation_p.E455K	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	455					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GTGCTGCTTTCCTCACCAGGT	0.478000													20	29					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118313343	118313343	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118313343C>T	ENST00000369221.2	+	6	592	c.564C>T	c.(562-564)cgC>cgT	p.R188R		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	188					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CCATTGGACGCATCACAGGTT	0.547000													11	14					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108163617	108163617	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:108163617G>A	ENST00000273353.3	-	23	2641	c.2585C>T	c.(2584-2586)gCt>gTt	p.A862V		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	862						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CTTCAGTCCAGCTACTTCTTC	0.443000													32	54					0	0	1	0	0
NELFCD	51497	broad.mit.edu	37	20	57564939	57564939	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:57564939G>A	ENST00000602795.1	+	7	786	c.738G>A	c.(736-738)acG>acA	p.T246T	NELFCD_ENST00000344018.3_Silent_p.T237T					negative elongation factor complex member C/D																		GGGAGCACACGTACCTGTTTG	0.642000													23	29					0	0	1	0	0
HERC2P2	0	broad.mit.edu	37	15	23330118	23330118	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:23330118G>T	ENST00000560464.1	-	0	1419																											CAGGAGCGCAGACCTCCTTGT	0.383000													36	9					5.44703e-19	6.02136e-19	1	1	0
GIT2	9815	broad.mit.edu	37	12	110429499	110429499	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:110429499C>T	ENST00000360185.4	-	2	283	c.119G>A	c.(118-120)aGt>aAt	p.S40N	GIT2_ENST00000551209.1_Missense_Mutation_p.S40N|GIT2_ENST00000320063.9_Missense_Mutation_p.S40N|GIT2_ENST00000361006.5_Missense_Mutation_p.S40N|GIT2_ENST00000457474.2_Missense_Mutation_p.S40N|GIT2_ENST00000553118.1_Missense_Mutation_p.S40N|GIT2_ENST00000338373.5_Missense_Mutation_p.S40N|GIT2_ENST00000355312.3_Missense_Mutation_p.S40N|GIT2_ENST00000354574.4_Missense_Mutation_p.S40N|GIT2_ENST00000343646.5_Missense_Mutation_p.S40N|GIT2_ENST00000547815.1_Missense_Mutation_p.S40N|GIT2_ENST00000356259.4_Missense_Mutation_p.S40N			Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	40	Arf-GAP.				regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						GCGCCCTAGACTCCGATGGAC	0.483000													23	40					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24562792	24562792	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:24562792G>A	ENST00000398319.2	+	32	5578	c.5193G>A	c.(5191-5193)cgG>cgA	p.R1731R	CABIN1_ENST00000405822.2_Silent_p.R1652R|CABIN1_ENST00000263119.5_Silent_p.R1731R|CABIN1_ENST00000337989.7_Silent_p.R156R	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1731					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TCAACCACCGGCCTGTGGCCA	0.667000													11	12					0	0	1	0	0
TIPARP	25976	broad.mit.edu	37	3	156411910	156411910	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:156411910A>G	ENST00000461166.1	+	3	1607	c.1019A>G	c.(1018-1020)aAc>aGc	p.N340S	TIPARP_ENST00000486483.1_Missense_Mutation_p.N340S|TIPARP_ENST00000295924.7_Missense_Mutation_p.N340S|TIPARP_ENST00000542783.1_Missense_Mutation_p.N340S	NM_001184717.1	NP_001171646.1	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	340	WWE.						NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AGCAATGTCAACTCTATTTAC	0.418000													36	60					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4285377	4285377	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:4285377C>T	ENST00000404826.2	+	44	6460	c.6321C>T	c.(6319-6321)ggC>ggT	p.G2107G	SDK1_ENST00000389531.3_Silent_p.G2087G|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2107					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGTACAACGGCGCCGTGCTGA	0.607000													13	17					0	0	1	0	0
CSTF2T	23283	broad.mit.edu	37	10	53457635	53457635	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:53457635G>A	ENST00000331173.4	-	1	1720	c.1675C>T	c.(1675-1677)Cct>Tct	p.P559S	PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373980.4_Intron|PRKG1_ENST00000373985.1_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	559					mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		AAActgctaggctggcttcca	0.532000													4	13					0	0	1	0	0
AGT	183	broad.mit.edu	37	1	230845754	230845754	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:230845754G>A	ENST00000366667.4	-	2	1057	c.843C>T	c.(841-843)taC>taT	p.Y281Y		NM_000029.3	NP_000020.1	P01019	ANGT_HUMAN	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	281			Y -> C (associated with susceptibility to hypertension; alters the structure, glycosylation and secretion of angiotensinogen; dbSNP:rs56073403).		activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	GGAAGTGGACGTAGGTGTTGA	0.547000													63	98					0	0	1	0	0
RAB19	401409	broad.mit.edu	37	7	140111851	140111851	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:140111851C>A	ENST00000275874.5	+	4	718	c.520C>A	c.(520-522)Ctg>Atg	p.L174M	RAB19_ENST00000356407.3_Missense_Mutation_p.L127M|RAB19_ENST00000537763.1_Missense_Mutation_p.L127M			A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	127					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			breast(3)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	9	Melanoma(164;0.0142)					GGTCATTATGCTGATTGGTAT	0.428000													46	101					7.77092e-38	8.72875e-38	1	1	0
BMS1	9790	broad.mit.edu	37	10	43325850	43325850	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:43325850C>T	ENST00000374518.4	+	22	3661	c.3598C>T	c.(3598-3600)Cgc>Tgc	p.R1200C		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	1200					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity	p.R1200G(1)		NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GGCCGTCATACGCGAGCCTCA	0.512000													21	30					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39237759	39237759	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:39237759G>A	ENST00000426016.1	-	16	2562	c.2476C>T	c.(2476-2478)Cga>Tga	p.R826*	SOS1_ENST00000395038.2_Nonsense_Mutation_p.R826*|SOS1_ENST00000402219.2_Nonsense_Mutation_p.R826*			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	826	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				GTGGTATGTCGAATCATTTTC	0.338000									Noonan syndrome				21	34					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26572045	26572045	+	Silent	SNP	G	G	A	rs145667380	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:26572045G>A	ENST00000381340.3	-	50	7463	c.7047C>T	c.(7045-7047)caC>caT	p.H2349H	RP11-513G19.1_ENST00000535324.1_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2349					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					CATACGCCACGTGATAGAGAA	0.443000													7	25					0	0	1	0	0
WBP7	0	broad.mit.edu	37	19	36219726	36219726	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36219726G>A	ENST00000222270.7	+	20	4623	c.4623G>A	c.(4621-4623)gcG>gcA	p.A1541A	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Silent_p.A1541A	NM_014727.1	NP_055542.1																					ATGTCTATGCGCAGTGGAGAC	0.617000													7	13					0	0	1	0	0
SLC22A24	283238	broad.mit.edu	37	11	62910984	62910984	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62910984G>A	ENST00000417740.1	-	1	709	c.268C>T	c.(268-270)Cgc>Tgc	p.R90C	SLC22A10_ENST00000525620.1_Intron|SLC22A24_ENST00000326192.5_Missense_Mutation_p.R90C	NM_001136506.2	NP_001129978.2			solute carrier family 22, member 24											kidney(1)|stomach(1)	2						TGGATAAAGCGCTGACACTTC	0.557000													10	16					0	0	1	0	0
SLC6A12	6539	broad.mit.edu	37	12	304491	304491	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:304491G>A	ENST00000428720.1	-	13	2072	c.1329C>T	c.(1327-1329)ggC>ggT	p.G443G	SLC6A12_ENST00000424061.2_Silent_p.G443G|SLC6A12_ENST00000397296.2_Silent_p.G443G|SLC6A12_ENST00000359674.4_Silent_p.G443G|SLC6A12_ENST00000536824.1_Silent_p.G443G	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	443					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			TGTACATCCCGCCCTGTGGGG	0.562000													17	19					0	0	1	0	0
ZNF436	80818	broad.mit.edu	37	1	23689057	23689057	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:23689057G>A	ENST00000314011.4	-	4	954	c.818C>T	c.(817-819)aCg>aTg	p.T273M	ZNF436_ENST00000374608.3_Missense_Mutation_p.T273M|ZNF436_ENST00000374609.1_Missense_Mutation_p.T273M	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		TTTCTCACCCGTGTGGGTCCT	0.532000													45	66					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58785293	58785293	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:58785293G>A	ENST00000355431.3	+	6	681	c.308G>A	c.(307-309)cGt>cAt	p.R103H	ARID4A_ENST00000348476.3_Missense_Mutation_p.R103H|ARID4A_ENST00000431317.2_Missense_Mutation_p.R103H|ARID4A_ENST00000395168.3_Missense_Mutation_p.R103H	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	103					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						ACATTGAGACGTACCTCACTT	0.388000													23	41					0	0	1	0	0
SLC3A1	6519	broad.mit.edu	37	2	44503055	44503055	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:44503055C>A	ENST00000260649.6	+	1	457	c.381C>A	c.(379-381)taC>taA	p.Y127*	SLC3A1_ENST00000410056.3_Nonsense_Mutation_p.Y127*|SLC3A1_ENST00000409387.1_Nonsense_Mutation_p.Y127*|SLC3A1_ENST00000409741.1_Nonsense_Mutation_p.Y127*|SLC3A1_ENST00000409229.3_Nonsense_Mutation_p.Y127*	NM_000341.3	NP_000332.2	Q07837	SLC31_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 1	127					carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity	p.Y127*(1)		breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(3)	26		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	ACCAGATCTACCCAAGGTCTT	0.527000													20	29					1.22574e-08	1.29596e-08	1	1	0
IFFO1	25900	broad.mit.edu	37	12	6657293	6657293	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6657293C>T	ENST00000436152.2	-	9	1031	c.472G>A	c.(472-474)Gat>Aat	p.D158N	IFFO1_ENST00000465801.1_Missense_Mutation_p.D157N|IFFO1_ENST00000336604.4_Missense_Mutation_p.D464N|IFFO1_ENST00000356896.4_Missense_Mutation_p.D465N|IFFO1_ENST00000396840.2_Missense_Mutation_p.D461N			Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan 1	461						intermediate filament				central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	20						GACTCCGTATCTTTAATCACC	0.572000													63	109					0	0	1	0	0
LLGL1	3996	broad.mit.edu	37	17	18139975	18139975	+	Silent	SNP	G	G	A	rs137941953	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18139975G>A	ENST00000316843.4	+	12	1503	c.1407G>A	c.(1405-1407)ccG>ccA	p.P469P		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	469					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					CGCTGCGGCCGCTCTATAAGC	0.662000													15	13					0	0	1	0	0
TSG101	7251	broad.mit.edu	37	11	18502173	18502173	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18502173G>T	ENST00000251968.3	-	10	1508	c.1093C>A	c.(1093-1095)Ctt>Att	p.L365I	TSG101_ENST00000536719.1_Intron|TSG101_ENST00000357193.3_Missense_Mutation_p.L260I	NM_006292.3	NP_006283.1	Q99816	TS101_HUMAN	tumor susceptibility 101	365	SB.				cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	22						CGGGACAGAAGACGTACATGC	0.443000													7	27					0.00198382	0.0020125	1	1	0
UBA2	10054	broad.mit.edu	37	19	34942995	34942995	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:34942995G>A	ENST00000439527.2	+	10	1191	c.693G>A	c.(691-693)gaG>gaA	p.E231E	UBA2_ENST00000246548.4_Silent_p.E327E			Q9UBT2	SAE2_HUMAN	ubiquitin-like modifier activating enzyme 2	327					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	20	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			AGAGCATCGAGACTTTGAGAG	0.428000													34	62					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121630452	121630452	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:121630452C>T	ENST00000489711.1	+	4	755	c.367C>T	c.(367-369)Ctt>Ttt	p.L123F	SLC15A2_ENST00000295605.2_Intron	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	123					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GGTGTATGTGCTTGGCCATGT	0.413000													5	26					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190569831	190569831	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190569831G>A	ENST00000520309.1	+	8	1879	c.1791G>A	c.(1789-1791)acG>acA	p.T597T	ANKAR_ENST00000438402.2_Silent_p.T597T|ANKAR_ENST00000281412.6_Silent_p.T361T|ANKAR_ENST00000431575.2_Silent_p.T526T|ANKAR_ENST00000313581.4_Silent_p.T597T	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	597						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			CTGATTACACGCTTTCTGAAA	0.438000													37	72					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58117342	58117342	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58117342G>A	ENST00000332854.6	+	3	669	c.449G>A	c.(448-450)gGg>gAg	p.G150E	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAAGTGGATGGGGACCAGGCC	0.473000													6	49					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79240097	79240097	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:79240097G>A	ENST00000264895.6	+	18	2534	c.2094G>A	c.(2092-2094)caG>caA	p.Q698Q	FRAS1_ENST00000325942.6_Silent_p.Q698Q|FRAS1_ENST00000264899.6_Silent_p.Q698Q	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	698					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GTCTAGCCCAGTGTAGAGCCC	0.522000													58	75					0	0	1	0	0
MAP3K3	4215	broad.mit.edu	37	17	61769176	61769176	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61769176C>T	ENST00000361357.3	+	15	1839	c.1521C>T	c.(1519-1521)ggC>ggT	p.G507G	MAP3K3_ENST00000579585.1_Silent_p.G507G|MAP3K3_ENST00000361733.3_Silent_p.G476G|MAP3K3_ENST00000577395.1_Silent_p.G472G|MAP3K3_ENST00000584573.1_Silent_p.G503G	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	476	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						TCCTGGAGGGCATGTCCTACC	0.562000													45	54					0	0	1	0	0
NCF4	4689	broad.mit.edu	37	22	37261022	37261022	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37261022G>A	ENST00000397147.4	+	3	363	c.179G>A	c.(178-180)cGc>cAc	p.R60H	NCF4_ENST00000248899.6_Missense_Mutation_p.R60H|CTA-833B7.2_ENST00000431290.1_RNA|CTA-833B7.2_ENST00000330602.2_RNA	NM_013416.3	NP_038202.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	60	PX.				cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						CGCCGCTACCGCCAGTTCCAT	0.602000													31	45					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131482247	131482247	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131482247C>T	ENST00000291906.4	+	20	2720	c.2327C>T	c.(2326-2328)gCc>gTc	p.A776V	PKN3_ENST00000485301.1_3'UTR	NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	776	Protein kinase.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						AACATGGACGCCCCCTACCCC	0.627000													41	46					0	0	1	0	0
RBPMS	11030	broad.mit.edu	37	8	30416412	30416412	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:30416412G>A	ENST00000320203.4	+	7	1119	c.537G>A	c.(535-537)tgG>tgA	p.W179*	RBPMS_ENST00000538486.1_Nonsense_Mutation_p.W136*|RBPMS_ENST00000287771.5_3'UTR|RBPMS_ENST00000397323.4_Nonsense_Mutation_p.W179*	NM_006867.2	NP_006858.1	Q93062	RBPMS_HUMAN	RNA binding protein with multiple splicing	179					positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|nucleus	nucleotide binding|poly(A) RNA binding|protein binding|transcription coactivator activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(542;0.144)|Kidney(114;0.172)		AGATGCGCTGGCTCCCTCCCT	0.562000													27	34					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52544490	52544490	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52544490C>T	ENST00000321725.6	+	25	2830	c.2754C>T	c.(2752-2754)acC>acT	p.T918T		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	918	EGF-like 8.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCTGCCACACCGATGCCCTCT	0.637000													12	14					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489410	133489410	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:133489410G>T	ENST00000409261.1	-	17	5716	c.5343C>A	c.(5341-5343)cgC>cgA	p.R1781R	NCKAP5_ENST00000409213.1_Silent_p.R462R|NCKAP5_ENST00000405974.3_Silent_p.R462R|NCKAP5_ENST00000317721.6_Silent_p.R1781R	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1781							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TATCTGCAGGGCGCTGGCCGT	0.587000													9	64					2.74318e-10	2.93027e-10	1	1	0
PSMB3	5691	broad.mit.edu	37	17	36918703	36918703	+	Missense_Mutation	SNP	C	C	A	rs1804235		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36918703C>A	ENST00000225426.4	+	5	605	c.514C>A	c.(514-516)Ctg>Atg	p.L172M		NM_002795.2	NP_002786.2	P49720	PSB3_HUMAN	proteasome (prosome, macropain) subunit, beta type, 3	172					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(1)	4						CCAAGCCATGCTGAATGCTGT	0.542000													4	52					0.00024832	0.000253518	1	1	0
SLC9A8	23315	broad.mit.edu	37	20	48472001	48472001	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:48472001C>T	ENST00000417961.1	+	8	854	c.644C>T	c.(643-645)gCt>gTt	p.A215V	SLC9A8_ENST00000541138.1_5'UTR|SLC9A8_ENST00000361573.2_Missense_Mutation_p.A199V|SLC9A8_ENST00000539601.1_5'UTR	NM_001260491.1|NM_015266.2	NP_001247420.1|NP_056081.1	Q9Y2E8	SL9A8_HUMAN	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	199						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			CTAATATCTGCTGTCGATCCA	0.448000													36	60					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46331150	46331150	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46331150G>A	ENST00000245934.7	-	15	2256	c.2012C>T	c.(2011-2013)gCg>gTg	p.A671V		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	671					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GATGAGTGGCGCCTCCAGCAC	0.647000													38	68					0	0	1	0	0
PTGER4	5734	broad.mit.edu	37	5	40681751	40681751	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:40681751G>A	ENST00000302472.3	+	2	1680	c.656G>A	c.(655-657)cGc>cAc	p.R219H	PTGER4_ENST00000514343.1_3'UTR	NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	219					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						CAGTTCATGCGCCGCACCTCG	0.711000													9	3					0	0	1	0	0
USP12	219333	broad.mit.edu	37	13	27669938	27669938	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:27669938C>T	ENST00000282344.6	-	4	629	c.373G>A	c.(373-375)Gcc>Acc	p.A125T		NM_182488.3	NP_872294.2	O75317	UBP12_HUMAN	ubiquitin specific peptidase 12	125					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		AATTCATGGGCATCTTGTTGC	0.264000													8	25					0	0	1	0	0
ERAL1	26284	broad.mit.edu	37	17	27187545	27187545	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27187545C>T	ENST00000254928.5	+	10	1385	c.1288C>T	c.(1288-1290)Cgc>Tgc	p.R430C		NM_005702.2	NP_005693.1	O75616	ERAL1_HUMAN	Era-like 12S mitochondrial rRNA chaperone 1	430	KH type-2.				ribosomal small subunit assembly	mitochondrial inner membrane|mitochondrial matrix	GTP binding|ribosomal small subunit binding|rRNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(2)	11	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.12e-05)|all cancers(11;5.32e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.105)			TGTTGACATCCGCCTCTCTGT	0.562000													28	45					0	0	1	0	0
TSACC	128229	broad.mit.edu	37	1	156316633	156316633	+	Missense_Mutation	SNP	G	G	A	rs117266642	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156316633G>A	ENST00000368255.3	+	4	598	c.238G>A	c.(238-240)Gcc>Acc	p.A80T	TSACC_ENST00000481479.1_3'UTR|TSACC_ENST00000368254.1_Missense_Mutation_p.A80T|TSACC_ENST00000368251.1_Missense_Mutation_p.A80T|TSACC_ENST00000368253.1_Missense_Mutation_p.A80T|TSACC_ENST00000368252.1_Missense_Mutation_p.A80T	NM_144627.3	NP_653228.1			TSSK6 activating co-chaperone																		GACCCAGCTCGCCCAACAACA	0.507000													73	89					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168314939	168314939	+	Missense_Mutation	SNP	G	G	A	rs149079362	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:168314939G>A	ENST00000366806.2	+	16	2271	c.2129G>A	c.(2128-2130)cGg>cAg	p.R710Q	MLLT4_ENST00000344191.4_Missense_Mutation_p.R710Q|MLLT4_ENST00000351017.4_Missense_Mutation_p.R717Q|MLLT4_ENST00000392112.1_Missense_Mutation_p.R694Q|MLLT4_ENST00000447894.2_Missense_Mutation_p.R710Q|MLLT4_ENST00000392108.3_Missense_Mutation_p.R710Q|MLLT4_ENST00000400822.3_Missense_Mutation_p.R709Q			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	710	Dilute.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GACCTTAGTCGGATCACACTG	0.403000			T	MLL	AL								15	33					0	0	1	0	0
WDR82	80335	broad.mit.edu	37	3	52293788	52293788	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52293788C>T	ENST00000296490.3	-	6	925	c.644G>A	c.(643-645)gGc>gAc	p.G215D		NM_025222.3	NP_079498.2	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	215					histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding								BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		AATGAAGCTGCCGTTGGTGGA	0.463000													80	124					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20108894	20108894	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:20108894G>A	ENST00000395530.2	+	2	1497	c.1289G>A	c.(1288-1290)cGt>cAt	p.R430H	SPECC1_ENST00000395522.2_Missense_Mutation_p.R430H|SPECC1_ENST00000395529.3_Missense_Mutation_p.R511H|SPECC1_ENST00000395525.3_Missense_Mutation_p.R430H|AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000472876.1_Intron|SPECC1_ENST00000261503.5_Missense_Mutation_p.R511H|SPECC1_ENST00000395527.4_Missense_Mutation_p.R511H|SPECC1_ENST00000536879.1_Intron	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	511						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		ATGATTAAACGTCTGAAGGAA	0.398000													22	32					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113565671	113565671	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:113565671C>T	ENST00000546530.1	-	5	529	c.244G>A	c.(244-246)Gac>Aac	p.D82N	RASAL1_ENST00000548055.1_Missense_Mutation_p.D82N|RASAL1_ENST00000446861.3_Missense_Mutation_p.D82N|RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000261729.5_Missense_Mutation_p.D82N	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	82	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						CCGATGATGTCGTCGTGCCTG	0.672000													27	33					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55814226	55814226	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55814226G>A	ENST00000309383.1	+	10	1296	c.1019G>A	c.(1018-1020)cGc>cAc	p.R340H	BRSK1_ENST00000326848.7_Missense_Mutation_p.R35H|BRSK1_ENST00000585418.1_Missense_Mutation_p.R340H|BRSK1_ENST00000590333.1_Missense_Mutation_p.R356H	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	340	UBA.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity	p.R340H(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CGCGAGCTGCGCAGTGAGGAG	0.662000													9	27					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73574912	73574912	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:73574912G>A	ENST00000224721.6	+	69	9962	c.9957G>A	c.(9955-9957)acG>acA	p.T3319T	CDH23_ENST00000398788.3_Silent_p.T1074T|CDH23_ENST00000475158.1_3'UTR	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	3314					calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CGCTGGAGACGCTGACCGCTG	0.662000													7	5					0	0	1	0	0
STAP2	55620	broad.mit.edu	37	19	4327199	4327199	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4327199C>T	ENST00000600324.1	-	8	752	c.685G>A	c.(685-687)Gtg>Atg	p.V229M	STAP2_ENST00000594605.1_Missense_Mutation_p.V229M|STAP2_ENST00000597593.1_5'UTR	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	229	SH2.					cytoplasm|nucleus	protein binding	p.V229M(1)		central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGTTGACCACGGCGTCCAGG	0.592000													23	30					0	0	1	0	0
LRRC3B	116135	broad.mit.edu	37	3	26751371	26751371	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:26751371T>C	ENST00000396641.2	+	2	800	c.208T>C	c.(208-210)Tat>Cat	p.Y70H	LRRC3B_ENST00000417744.1_Missense_Mutation_p.Y70H|LRRC3B_ENST00000456208.2_Missense_Mutation_p.Y70H	NM_052953.2	NP_443185.1	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B	70						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						AGTCTTACTGTATCTGGACTC	0.408000													13	59					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198432	170198432	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:170198432G>A	ENST00000231706.4	-	7	1954	c.1639C>T	c.(1639-1641)Cgg>Tgg	p.R547W	CLDN11_ENST00000486975.1_Intron|CLDN11_ENST00000451576.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	547						integral to membrane	amino acid transmembrane transporter activity	p.R547W(1)		central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AGGCCCAGCCGGATTCTCATG	0.507000													33	57					0	0	1	0	0
GULP1	51454	broad.mit.edu	37	2	189448999	189448999	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:189448999G>A	ENST00000409580.1	+	11	1331	c.617G>A	c.(616-618)aGt>aAt	p.S206N	GULP1_ENST00000409805.1_Missense_Mutation_p.S103N|GULP1_ENST00000409609.1_Missense_Mutation_p.S206N|GULP1_ENST00000409843.1_Missense_Mutation_p.S206N|GULP1_ENST00000409830.1_Missense_Mutation_p.S206N|GULP1_ENST00000359135.3_Missense_Mutation_p.S206N			Q9UBP9	GULP1_HUMAN	GULP, engulfment adaptor PTB domain containing 1	206					apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			endometrium(3)|large_intestine(2)|lung(5)|ovary(1)|skin(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)			CAGGCAGGCAGTATGACACCT	0.363000													41	74					0	0	1	0	0
SDHA	6389	broad.mit.edu	37	5	233681	233681	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:233681C>T	ENST00000264932.6	+	8	1100	c.985C>T	c.(985-987)Cga>Tga	p.R329*	SDHA_ENST00000510361.1_Nonsense_Mutation_p.R281*|SDHA_ENST00000504309.1_Nonsense_Mutation_p.R329*	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	329					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	GTTTATGGAGCGATACGCCCC	0.517000									Familial Paragangliomas				52	69					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129874955	129874955	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:129874955C>T	ENST00000254667.3	+	18	1967	c.1688C>T	c.(1687-1689)gCc>gTc	p.A563V	PTPRE_ENST00000306042.5_Missense_Mutation_p.A505V|PTPRE_ENST00000419012.2_Missense_Mutation_p.A563V	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	563	Tyrosine-protein phosphatase 2.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				CTTTCAGAAGCCATCAGTATA	0.428000													42	77					0	0	1	0	0
SDHB	6390	broad.mit.edu	37	1	17349119	17349119	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:17349119G>A	ENST00000375499.3	-	7	899	c.749C>T	c.(748-750)aCa>aTa	p.T250I		NM_003000.2	NP_002991.2	P21912	DHSB_HUMAN	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	250					respiratory electron transport chain|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	2 iron, 2 sulfur cluster binding|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|protein binding|succinate dehydrogenase (ubiquinone) activity|ubiquinone binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)	10		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0049)|COAD - Colon adenocarcinoma(227;1.18e-05)|BRCA - Breast invasive adenocarcinoma(304;2.41e-05)|Kidney(64;0.000188)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)	Succinic acid(DB00139)	ACAGGTCCTTGTGCAGTTCAT	0.557000			"""Mis, N, F"""			"""paraganglioma, pheochromocytoma"""			Familial Paragangliomas;Cowden syndrome;Carney-Stratakis syndrome				50	58					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906504	164906504	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:164906504G>A	ENST00000475390.1	-	2	2558	c.2115C>T	c.(2113-2115)tgC>tgT	p.C705C	SLITRK3_ENST00000241274.3_Silent_p.C705C			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	705						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						ACAGCCTGTGGCATTGCATTT	0.592000										HNSCC(40;0.11)			20	42					0	0	1	0	0
PTGIR	0	broad.mit.edu	37	19	47127272	47127272	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47127272C>T	ENST00000291294.2	-	2	344	c.211G>A	c.(211-213)Gtg>Atg	p.V71M	PTGIR_ENST00000596260.1_Missense_Mutation_p.V71M|PTGIR_ENST00000594275.1_Intron|PTGIR_ENST00000597185.1_Intron|PTGIR_ENST00000598865.1_Intron	NM_000960.3	NP_000951.1	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	71					cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	13		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	GCCACGAACACGGCCGGGCTC	0.731000													4	2					0	0	1	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555201	44555201	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:44555201C>T	ENST00000330682.2	-	1	1248	c.1013G>A	c.(1012-1014)cGc>cAc	p.R338H	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	338	Activation domain (By similarity).|Interaction with elongin BC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						GCACTGCTGGCGCAGCGTCGG	0.652000													19	715					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102849474	102849474	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:102849474G>A	ENST00000264257.2	+	10	1313	c.1187G>A	c.(1186-1188)aGc>aAc	p.S396N	IL1RL2_ENST00000481806.1_3'UTR|IL1RL2_ENST00000539491.1_Missense_Mutation_p.S396N|IL1RL2_ENST00000441515.2_Missense_Mutation_p.S278N	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	396	TIR.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						CACAAGGAAAGCCAGAGGCAT	0.463000													33	39					0	0	1	0	0
RCC1	1104	broad.mit.edu	37	1	28858370	28858370	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:28858370C>T	ENST00000373833.6	+	6	414	c.129C>T	c.(127-129)ggC>ggT	p.G43G	RCC1_ENST00000373832.1_Silent_p.G43G|RCC1_ENST00000398958.2_Silent_p.G43G|RCC1_ENST00000373831.3_Silent_p.G74G			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	43					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		TAGGCCAGGGCGACGTGGGCC	0.597000													13	25					0	0	1	0	0
ORMDL3	94103	broad.mit.edu	37	17	38080399	38080399	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38080399G>A	ENST00000394169.1	-	4	1552	c.58C>T	c.(58-60)Cgt>Tgt	p.R20C	ORMDL3_ENST00000584220.1_Missense_Mutation_p.R20C|ORMDL3_ENST00000579695.1_Missense_Mutation_p.R20C|ORMDL3_ENST00000304046.2_Missense_Mutation_p.R20C			Q8N138	ORML3_HUMAN	ORM1-like 3 (S. cerevisiae)	20					ceramide metabolic process	integral to membrane|SPOTS complex	protein binding			endometrium(3)|kidney(1)|lung(1)	5	Colorectal(19;0.000442)		Lung(15;0.0234)			CAGATGCCACGGCTGTTCATC	0.597000													17	20					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66259059	66259059	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66259059G>A	ENST00000532677.1	+	8	1351	c.950G>A	c.(949-951)cGc>cAc	p.R317H	DPP3_ENST00000541961.1_Missense_Mutation_p.R298H|DPP3_ENST00000531863.1_Missense_Mutation_p.R318H|DPP3_ENST00000453114.1_Missense_Mutation_p.R298H|DPP3_ENST00000360510.2_Missense_Mutation_p.R298H|DPP3_ENST00000530165.1_Missense_Mutation_p.R268H	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	298					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						AGGGGCTCCCGCTTCTGGATC	0.652000											OREG0021109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	9					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52699573	52699573	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:52699573G>A	ENST00000293525.5	+	6	1078		c.e6+1		KRT86_ENST00000423955.2_Splice_Site|KRT86_ENST00000544024.1_Splice_Site	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86						cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		CAAGTGCCAGGTATGGGGCAT	0.587000													25	48					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7734419	7734419	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7734419G>A	ENST00000572933.1	+	80	13706	c.12246G>A	c.(12244-12246)gaG>gaA	p.E4082E	DNAH2_ENST00000389173.2_Silent_p.E4082E			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	4082					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAGCACTGGAGACTTATTTCA	0.532000													124	151					0	0	1	0	0
MAP1LC3C	440738	broad.mit.edu	37	1	242159540	242159540	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:242159540C>A	ENST00000357246.3	-	4	433	c.369G>T	c.(367-369)gaG>gaT	p.E123D		NM_001004343.2	NP_001004343.1	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3 gamma	123					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AGCCAAATGTCTCCTGGGAGG	0.567000													26	39					1.1804e-14	1.28927e-14	1	1	0
C6orf70	0	broad.mit.edu	37	6	170169676	170169676	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:170169676G>A	ENST00000588451.1	+	11	1205	c.692G>A	c.(691-693)cGc>cAc	p.R231H	C6orf70_ENST00000366772.2_Missense_Mutation_p.R367H|C6orf70_ENST00000418781.3_Missense_Mutation_p.R367H|C6orf70_ENST00000392095.4_Missense_Mutation_p.R241H|C6orf70_ENST00000366773.3_Missense_Mutation_p.R367H			Q5T6L9	CF070_HUMAN		367						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		GAGGGTCCCCGCATAAGAGAT	0.403000													4	35					0	0	1	0	0
SEMA7A	8482	broad.mit.edu	37	15	74703066	74703066	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:74703066C>T	ENST00000261918.4	-	14	2448	c.1900G>A	c.(1900-1902)Ggc>Agc	p.G634S	SEMA7A_ENST00000543145.2_Missense_Mutation_p.G620S|SEMA7A_ENST00000542748.1_Missense_Mutation_p.G469S	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	634					axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						GCCATGATGCCGTCCTCGGGC	0.667000													14	12					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72139213	72139213	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:72139213G>A	ENST00000555818.1	+	9	3326	c.2978G>A	c.(2977-2979)cGc>cAc	p.R993H	SIPA1L1_ENST00000358550.2_Missense_Mutation_p.R993H|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.R993H|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.R468H	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	993	PDZ.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CAGGGCAGTCGCCTGGTGGAG	0.582000													21	33					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9052014	9052014	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:9052014G>A	ENST00000382496.5	-	20	3481	c.2816C>T	c.(2815-2817)cCg>cTg	p.P939L		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	939	TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						AAACACACACGGCCGGCTCTC	0.512000													26	35					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55588008	55588008	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55588008A>G	ENST00000333976.4	+	1	923	c.903A>G	c.(901-903)acA>acG	p.T301T		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				TCAAGGATACAGTCACCGAGA	0.418000													11	28					0	0	1	0	0
ZNF785	146540	broad.mit.edu	37	16	30594700	30594700	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30594700C>T	ENST00000395216.2	-	3	558	c.399G>A	c.(397-399)gcG>gcA	p.A133A	AC002310.7_ENST00000492040.1_RNA|ZNF785_ENST00000470110.1_Silent_p.A118A	NM_152458.6	NP_689671.2	A8K8V0	ZN785_HUMAN	zinc finger protein 785	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9						CCACTTCATGCGCCACCTCTT	0.522000													27	39					0	0	1	0	0
SLTM	79811	broad.mit.edu	37	15	59191688	59191688	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:59191688C>T	ENST00000380516.2	-	7	1125	c.1038G>A	c.(1036-1038)ggG>ggA	p.G346G	SLTM_ENST00000536328.1_Intron	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	346					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GACCAGAGGCCCCAGTAGACG	0.443000													18	30					0	0	1	0	0
DHX35	60625	broad.mit.edu	37	20	37659397	37659397	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:37659397A>C	ENST00000252011.3	+	20	1967	c.1934A>C	c.(1933-1935)tAt>tCt	p.Y645S	DHX35_ENST00000373323.4_Missense_Mutation_p.Y614S|DHX35_ENST00000373325.2_Intron	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	645						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				TCAGTCCTCTATGCAGAGAAG	0.468000													7	39					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316868	30316868	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:30316868G>A	ENST00000375377.1	-	3	2310	c.2209C>T	c.(2209-2211)Cct>Tct	p.P737S		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	737										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						TCACCGGTAGGGAATGCTGTG	0.572000													12	25					0	0	1	0	0
PELO	53918	broad.mit.edu	37	5	52096778	52096778	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:52096778C>T	ENST00000274311.2	+	2	1535	c.550C>T	c.(550-552)Cgg>Tgg	p.R184W	ITGA1_ENST00000282588.6_Intron|PELO_ENST00000506949.1_Intron|ITGA1_ENST00000504086.1_Intron	NM_015946.4	NP_057030.3	Q9BRX2	PELO_HUMAN	pelota homolog (Drosophila)	184					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	11		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				GGCCTTGGAGCGGTTCTATGA	0.542000													16	35					0	0	1	0	0
CSTF2T	23283	broad.mit.edu	37	10	53457601	53457601	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:53457601G>T	ENST00000331173.4	-	1	1754	c.1709C>A	c.(1708-1710)aCt>aAt	p.T570N	PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373980.4_Intron|PRKG1_ENST00000373985.1_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	570					mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		ATCCTGTGGAGTGACCTGGCT	0.527000													9	16					1.12685e-05	1.16601e-05	1	1	0
INPP5F	22876	broad.mit.edu	37	10	121580392	121580392	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:121580392C>A	ENST00000361976.2	+	16	2087	c.1921C>A	c.(1921-1923)Ctg>Atg	p.L641M	INPP5F_ENST00000490818.1_3'UTR|INPP5F_ENST00000369080.3_Missense_Mutation_p.L31M	NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	641							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CGTGGATGTGCTGTTACTGCT	0.338000													35	45					6.33695e-27	7.08463e-27	1	1	0
PRUNE2	158471	broad.mit.edu	37	9	79321905	79321905	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:79321905C>A	ENST00000428286.1	-	8	5408	c.4208G>T	c.(4207-4209)aGc>aTc	p.S1403I	PRUNE2_ENST00000376718.3_Missense_Mutation_p.S1762I			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1762					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						ATCAGGGCTGCTTTGTTGATT	0.438000													11	39					0.000673444	0.000685014	1	1	0
RPS6KA3	6197	broad.mit.edu	37	X	20222195	20222195	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:20222195G>T	ENST00000379565.3	-	4	477	c.270C>A	c.(268-270)ggC>ggA	p.G90G	RPS6KA3_ENST00000544447.1_Silent_p.G62G|RPS6KA3_ENST00000540702.1_Silent_p.G62G|RPS6KA3_ENST00000379548.4_Silent_p.G61G	NM_004586.2	NP_004577.1	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 3	90	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(14)|lung(7)|ovary(1)|stomach(1)	41						TAGCATCAGAGCCTGAGATTT	0.333000													5	57					3.59834e-05	3.7043e-05	1	1	0
THBS1	7057	broad.mit.edu	37	15	39882195	39882195	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:39882195G>A	ENST00000260356.5	+	13	2281	c.2116G>A	c.(2116-2118)Gtg>Atg	p.V706M		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	706					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CCTGGTGTGCGTGGCCAATGC	0.552000													6	2					0	0	1	0	0
CHCHD2	51142	broad.mit.edu	37	7	56172109	56172109	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:56172109G>A	ENST00000395422.3	-	2	272	c.110C>T	c.(109-111)gCg>gTg	p.A37V		NM_016139.2	NP_057223.1	Q9Y6H1	CHCH2_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 2	37						mitochondrion				endometrium(1)|large_intestine(1)|lung(3)	5	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TGGGGGTGCCGCTGCTGGTGG	0.607000													9	19					0	0	1	0	0
ZMYM1	79830	broad.mit.edu	37	1	35580705	35580705	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:35580705C>T	ENST00000373330.1	+	11	3448	c.3274C>T	c.(3274-3276)Cgt>Tgt	p.R1092C	ZMYM1_ENST00000359858.4_Missense_Mutation_p.R1092C|ZMYM1_ENST00000373329.1_3'UTR			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	1092						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TACCCTGCCTCGTCTTAAGAC	0.403000													39	50					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234534276	234534276	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:234534276G>A	ENST00000040877.1	-	26	4094	c.4095C>T	c.(4093-4095)cgC>cgT	p.R1365R	TARBP1_ENST00000483404.1_Intron	NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1365					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			GGCCTGAAAGGCGTGGAAGGA	0.318000													15	8					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72338298	72338298	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:72338298A>G	ENST00000356056.5	-	2	1079	c.607T>C	c.(607-609)Tat>Cat	p.Y203H	MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000444904.1_Missense_Mutation_p.Y203H|MYO9A_ENST00000566885.1_Intron|MYO9A_ENST00000564571.1_Missense_Mutation_p.Y203H|MYO9A_ENST00000424560.1_Missense_Mutation_p.Y203H	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	203	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TGGTTATCATACATTTTGACA	0.363000													20	19					0	0	1	0	0
DYRK3	8444	broad.mit.edu	37	1	206821761	206821761	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:206821761G>T	ENST00000367106.1	+	4	1631	c.1158G>T	c.(1156-1158)caG>caT	p.Q386H	DYRK3_ENST00000489878.1_Intron|DYRK3_ENST00000367108.3_Missense_Mutation_p.Q386H|DYRK3_ENST00000367109.2_Missense_Mutation_p.Q406H			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	406	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			TAACAGGACAGCCTCTCTTCC	0.498000													36	67					6.53348e-20	7.23485e-20	1	1	0
PLG	5340	broad.mit.edu	37	6	161160103	161160103	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:161160103C>T	ENST00000308192.9	+	16	1944	c.1881C>T	c.(1879-1881)tcC>tcT	p.S627S		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	627	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TTTCTAGGTCCCCAAGGCCTT	0.507000													7	82					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139908134	139908134	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:139908134G>A	ENST00000297183.6	+	29	5727	c.5603G>A	c.(5602-5604)cGg>cAg	p.R1868Q	ANKHD1_ENST00000544120.1_Missense_Mutation_p.R251Q|ANKHD1_ENST00000360839.2_Missense_Mutation_p.R1868Q|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.R1868Q	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACAGATTCGGCATCCTCGC	0.498000													46	43					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35539668	35539668	+	Missense_Mutation	SNP	C	C	T	rs140417977		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:35539668C>T	ENST00000262878.4	-	11	1422	c.1223G>A	c.(1222-1224)cGc>cAc	p.R408H		NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	408					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				TGTAGAAATGCGATACTTTTT	0.358000													4	92					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075008	9075008	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9075008T>C	ENST00000397910.4	-	3	12641	c.12438A>G	c.(12436-12438)tcA>tcG	p.S4146S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4148	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGCTTGGCTGTGATGTATCCT	0.502000													33	47					0	0	1	0	0
C2orf73	129852	broad.mit.edu	37	2	54570996	54570996	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:54570996C>A	ENST00000398634.2	+	3	416	c.374C>A	c.(373-375)cCt>cAt	p.P125H	C2orf73_ENST00000491538.1_Intron|C2orf73_ENST00000405749.1_Missense_Mutation_p.P67H	NM_001100396.1	NP_001093866.1	Q8N5S3	CB073_HUMAN	chromosome 2 open reading frame 73	125										breast(2)	2						ATGCAAAAGCCTTCTTGTGGA	0.418000													17	22					3.52763e-06	3.66169e-06	1	1	0
CEP170	9859	broad.mit.edu	37	1	243329090	243329090	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:243329090G>T	ENST00000366542.1	-	13	2223	c.2172C>A	c.(2170-2172)agC>agA	p.S724R	CEP170_ENST00000366544.1_Missense_Mutation_p.S626R|RP11-261C10.4_ENST00000422938.1_RNA|RP11-261C10.4_ENST00000437499.1_RNA|CEP170_ENST00000366543.1_Missense_Mutation_p.S626R	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	724						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CAGGAGCAGAGCTGCCTAAGT	0.408000													39	59					1.07637e-12	1.16607e-12	1	1	0
TRAF6	7189	broad.mit.edu	37	11	36511685	36511685	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:36511685C>T	ENST00000526995.1	-	7	1518	c.1272G>A	c.(1270-1272)tgG>tgA	p.W424*	TRAF6_ENST00000348124.5_Nonsense_Mutation_p.W424*	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	424	MATH.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				CCTGGAAGGGCCAAGGGAGGT	0.483000													30	18					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64641529	64641529	+	Silent	SNP	C	C	T	rs149096693		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:64641529C>T	ENST00000413366.3	+	5	455	c.429C>T	c.(427-429)tgC>tgT	p.C143C		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	143					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	ACAAGCAATGCGTCATCAATG	0.517000													18	28					0	0	1	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737666	62737666	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:62737666G>A	ENST00000369768.1	-	1	858	c.519C>T	c.(517-519)ggC>ggT	p.G173G		NM_005286.2	NP_005277.2	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	173						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					GGACCGTGACGCCCAGCCAGA	0.667000													11	20					0	0	1	0	0
SSU72	29101	broad.mit.edu	37	1	1479341	1479341	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1479341A>G	ENST00000291386.3	-	4	702	c.391T>C	c.(391-393)Tgc>Cgc	p.C131R		NM_014188.2	NP_054907.1	Q9NP77	SSU72_HUMAN	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	131					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity			large_intestine(2)|lung(5)	7	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		ACAGGCTGGCAGGTCTCCTGT	0.557000													6	30					0	0	1	0	0
CHSY1	22856	broad.mit.edu	37	15	101718648	101718648	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:101718648G>A	ENST00000254190.3	-	3	1829	c.1354C>T	c.(1354-1356)Ctg>Ttg	p.L452L	CHSY1_ENST00000543813.1_5'UTR	NM_014918.4	NP_055733.2	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	452	Poly-Leu.				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(5)|skin(1)	24	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TACAGAAGCAGCAGGTCCAGG	0.517000													11	45					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111695045	111695045	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:111695045C>A	ENST00000435970.1	-	15	5095	c.4279G>T	c.(4279-4281)Gca>Tca	p.A1427S	REV3L_ENST00000358835.3_Missense_Mutation_p.A1505S|REV3L_ENST00000368805.1_Missense_Mutation_p.A1505S|REV3L_ENST00000368802.3_Missense_Mutation_p.A1505S			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1505					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TGAGAAAGTGCTTTGGTTTGT	0.368000								DNA polymerases (catalytic subunits)					38	71					4.14481e-20	4.59174e-20	1	1	0
C9orf69	90120	broad.mit.edu	37	9	139008328	139008328	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139008328C>T	ENST00000418388.1	-	2	921	c.419G>A	c.(418-420)tGa>tAa	p.*140*	C9orf69_ENST00000561457.1_3'UTR					chromosome 9 open reading frame 69											endometrium(1)	1		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.58e-07)|Epithelial(140;6.42e-06)		CCACGGCCCTCACATGTCCAC	0.647000													4	5					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84685161	84685161	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:84685161G>A	ENST00000286744.5	+	25	4407	c.4183G>A	c.(4183-4185)Gta>Ata	p.V1395I	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.V1395I	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1395						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GAGTAGAATCGTATTTCTGCA	0.423000													10	15					0	0	1	0	0
CORO7	79585	broad.mit.edu	37	16	4410482	4410482	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4410482C>T	ENST00000251166.4	-	20	2130	c.1985G>A	c.(1984-1986)cGg>cAg	p.R662Q	CORO7_ENST00000574025.1_Missense_Mutation_p.R577Q|CORO7_ENST00000539968.1_Missense_Mutation_p.R442Q|CORO7_ENST00000537233.2_Missense_Mutation_p.R644Q|CORO7-PAM16_ENST00000572467.1_Missense_Mutation_p.R662Q|CORO7_ENST00000423908.2_3'UTR	NM_024535.4	NP_078811.3			coronin 7											breast(3)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|prostate(2)|skin(2)|urinary_tract(2)	23						CCTGTAGACCCGCACACGCCC	0.652000													4	7					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1057328	1057328	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1057328C>T	ENST00000263094.6	+	35	5011	c.4780C>T	c.(4780-4782)Cca>Tca	p.P1594S	ABCA7_ENST00000435683.2_Missense_Mutation_p.P1456S|ABCA7_ENST00000433129.1_Missense_Mutation_p.P1594S	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1594					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTACTTGGTGCCAGCATGCAT	0.557000													59	98					0	0	1	0	0
POLG2	11232	broad.mit.edu	37	17	62493082	62493082	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62493082C>T	ENST00000539111.2	-	1	72	c.5G>A	c.(4-6)cGc>cAc	p.R2H		NM_007215.3	NP_009146.2	Q9UHN1	DPOG2_HUMAN	polymerase (DNA directed), gamma 2, accessory subunit	2					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(4)|skin(2)|stomach(1)|urinary_tract(1)	15	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			TACACGAGAGCGCATCTCTCT	0.587000													7	20					0	0	1	0	0
TXNDC2	0	broad.mit.edu	37	18	9887552	9887552	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:9887552T>C	ENST00000306084.6	+	2	1275	c.1076T>C	c.(1075-1077)aTc>aCc	p.I359T	TXNDC2_ENST00000357775.4_Missense_Mutation_p.I292T|TXNDC2_ENST00000536353.2_3'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	359	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						AAGGGTGACATCCCCAAGTCC	0.567000													23	43					0	0	1	0	0
EIF2D	1939	broad.mit.edu	37	1	206782805	206782805	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:206782805C>T	ENST00000271764.2	-	3	463	c.255G>A	c.(253-255)acG>acA	p.T85T	EIF2D_ENST00000367114.3_Silent_p.T85T	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	85					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						AGGACCACAGCGTGTACACTG	0.423000													8	46					0	0	1	0	0
ECI2	10455	broad.mit.edu	37	6	4130661	4130661	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:4130661C>T	ENST00000465828.1	-	4	641	c.356G>A	c.(355-357)gGc>gAc	p.G119D	ECI2_ENST00000361538.2_Missense_Mutation_p.G119D|C6orf201_ENST00000333388.5_Intron|ECI2_ENST00000380125.2_Missense_Mutation_p.G119D|ECI2_ENST00000413766.2_5'UTR|C6orf201_ENST00000380175.4_Intron|ECI2_ENST00000380118.3_Missense_Mutation_p.G149D			O75521	ECI2_HUMAN	enoyl-CoA delta isomerase 2	149	ACB.			S -> C (in Ref. 2; CAB66577).	fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	11						CTTTGTGATGCCATCTTCGGA	0.453000													21	45					0	0	1	0	0
LRRC8D	55144	broad.mit.edu	37	1	90399036	90399036	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:90399036C>T	ENST00000337338.5	+	3	816	c.409C>T	c.(409-411)Cga>Tga	p.R137*	LRRC8D_ENST00000394593.3_Nonsense_Mutation_p.R137*	NM_001134479.1	NP_001127951.1	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member D	137						integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(2)|skin(1)	29		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		TCCAACAGGTCGAAAAACAAA	0.413000													24	21					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144990902	144990902	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144990902G>A	ENST00000322810.4	-	32	13667	c.13498C>T	c.(13498-13500)Cgc>Tgc	p.R4500C	PLEC_ENST00000436759.2_Missense_Mutation_p.R4390C|PLEC_ENST00000398774.2_Missense_Mutation_p.R4331C|PLEC_ENST00000356346.3_Missense_Mutation_p.R4349C|PLEC_ENST00000357649.2_Missense_Mutation_p.R4367C|PLEC_ENST00000354589.3_Missense_Mutation_p.R4363C|PLEC_ENST00000527096.1_Missense_Mutation_p.R4386C|PLEC_ENST00000345136.3_Missense_Mutation_p.R4363C|PLEC_ENST00000354958.2_Missense_Mutation_p.R4341C	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4500	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GTCTTGGTGCGTGGGTCCTCG	0.647000													15	35					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53358594	53358594	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:53358594A>G	ENST00000566029.1	+	39	8642	c.8433A>G	c.(8431-8433)gtA>gtG	p.V2811V	CHD9_ENST00000398510.3_Silent_p.V2827V|CHD9_ENST00000564845.1_Silent_p.V2811V|CHD9_ENST00000447540.1_Silent_p.V2812V			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2827					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				CTTTTGATGTACAAAACAAAA	0.373000													5	7					0	0	1	0	0
NR1H3	10062	broad.mit.edu	37	11	47283152	47283152	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:47283152G>A	ENST00000467728.1	+	5	2001	c.763G>A	c.(763-765)Gcc>Acc	p.A255T	NR1H3_ENST00000395397.3_Missense_Mutation_p.A210T|NR1H3_ENST00000441012.2_Missense_Mutation_p.A255T|NR1H3_ENST00000527949.1_Intron|NR1H3_ENST00000407404.1_Intron|NR1H3_ENST00000405576.1_Intron|NR1H3_ENST00000481889.2_Missense_Mutation_p.A210T|NR1H3_ENST00000529540.1_3'UTR|NR1H3_ENST00000405853.3_Intron			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	255	Ligand-binding (Potential).				apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						GCAGCGCTTTGCCCACTTCAC	0.587000													19	25					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43253660	43253660	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:43253660C>T	ENST00000255226.6	+	18	3206	c.2390C>T	c.(2389-2391)gCg>gTg	p.A797V	RP11-116O18.3_ENST00000589510.1_RNA|SLC14A2_ENST00000586448.1_Missense_Mutation_p.A797V|SLC14A2_ENST00000589658.1_Missense_Mutation_p.A274V	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	797						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CTCACTATTGCGACGCCCTTT	0.562000													12	25					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142605796	142605796	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142605796C>T	ENST00000265310.1	-	15	2422	c.2074G>A	c.(2074-2076)Gcg>Acg	p.A692T		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	692					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CTCTGGGACGCGGTCCGGGAC	0.582000													22	24					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50750840	50750840	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:50750840C>T	ENST00000300589.2	+	6	2690	c.2585C>T	c.(2584-2586)tCc>tTc	p.S862F		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	862					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				TGTGCACACTCCATGGCTAAG	0.468000													48	61					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143793006	143793006	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:143793006G>A	ENST00000408949.2	+	1	866	c.806G>A	c.(805-807)cGg>cAg	p.R269Q		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					TCTCAAGAACGGAGGAAGATC	0.527000													83	139					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63444983	63444983	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:63444983C>T	ENST00000453546.1	-	10	1762	c.1673G>A	c.(1672-1674)gGc>gAc	p.G558D	ASB12_ENST00000396130.2_Missense_Mutation_p.G174D|ASB12_ENST00000362002.2_Missense_Mutation_p.G183D			Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	0						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						ATAGAGGGGGCCAGAACATGA	0.562000													3	15					0	0	1	0	0
SLTM	79811	broad.mit.edu	37	15	59209144	59209144	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:59209144G>A	ENST00000380516.2	-	3	392	c.305C>T	c.(304-306)gCt>gTt	p.A102V	SLTM_ENST00000557950.1_5'UTR|SLTM_ENST00000536328.1_5'UTR	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	102					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTTGATAAAAGCATCATCTTC	0.338000													12	28					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40933278	40933278	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40933278G>A	ENST00000246914.5	+	1	583	c.562G>A	c.(562-564)Gtg>Atg	p.V188M		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	188	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CTTCAAGACGGTGTATCGAGG	0.607000													5	35					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112672997	112672997	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112672997G>A	ENST00000550722.1	-	37	5756	c.5361C>T	c.(5359-5361)tcC>tcT	p.S1787S	HECTD4_ENST00000377560.5_Silent_p.S1761S|HECTD4_ENST00000430131.2_Silent_p.S1511S	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CTCCTTTCAAGGAATTCTTGG	0.448000													9	19					0	0	1	0	0
SLC19A3	80704	broad.mit.edu	37	2	228563579	228563579	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:228563579C>T	ENST00000258403.3	-	3	923	c.852G>A	c.(850-852)tgG>tgA	p.W284*	SLC19A3_ENST00000541617.1_Nonsense_Mutation_p.W280*|SLC19A3_ENST00000409287.1_Intron	NM_025243.3	NP_079519.1	Q9BZV2	S19A3_HUMAN	solute carrier family 19 (thiamine transporter), member 3	284					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|skin(3)	30		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	CGAAAGCCCACCATAGAGACC	0.458000													26	39					0	0	1	0	0
CAPN2	824	broad.mit.edu	37	1	223943318	223943318	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:223943318G>T	ENST00000295006.5	+	10	1581	c.1272G>T	c.(1270-1272)gaG>gaT	p.E424D	CAPN2_ENST00000433674.2_Missense_Mutation_p.E346D	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	424	Domain III.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		AGATGGGCGAGGACATGCACA	0.617000													4	19					0.00024832	0.000253518	1	1	0
GANC	2595	broad.mit.edu	37	15	42632023	42632023	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42632023G>A	ENST00000318010.8	+	17	2240	c.2000G>A	c.(1999-2001)cGa>cAa	p.R667Q		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	667					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		CGACTCATCCGAGAAGCCATC	0.557000													17	22					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66190620	66190620	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66190620G>A	ENST00000311034.2	+	5	901	c.725G>A	c.(724-726)cGc>cAc	p.R242H		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	242	PAS 2.				transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						GGCTTTGAGCGCAGTGAACTG	0.542000													16	17					0	0	1	0	0
INPP5F	22876	broad.mit.edu	37	10	121586586	121586586	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:121586586C>T	ENST00000361976.2	+	20	2859	c.2693C>T	c.(2692-2694)gCg>gTg	p.A898V	INPP5F_ENST00000369080.3_Missense_Mutation_p.A288V	NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	898							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		ATTGCCTCAGCGCCTCGATTG	0.468000													21	52					0	0	1	0	0
ASCL4	121549	broad.mit.edu	37	12	108169399	108169399	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:108169399T>C	ENST00000342331.4	+	1	1238	c.407T>C	c.(406-408)cTc>cCc	p.L136P		NM_203436.2	NP_982260.2	Q6XD76	ASCL4_HUMAN	achaete-scute family bHLH transcription factor 4	135					regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|central_nervous_system(1)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	13						GCCTGGGGGCTCGAGGGCGCG	0.706000													3	6					0	0	1	0	0
CPLX2	10814	broad.mit.edu	37	5	175306900	175306900	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:175306900T>A	ENST00000359546.4	+	5	900	c.257T>A	c.(256-258)cTg>cAg	p.L86Q	CPLX2_ENST00000393745.3_Missense_Mutation_p.L86Q|CPLX2_ENST00000515094.1_Missense_Mutation_p.L86Q	NM_001008220.1|NM_006650.3	NP_001008221.1|NP_006641.1	Q6PUV4	CPLX2_HUMAN	complexin 2	86	Interaction with the SNARE complex (By similarity).				mast cell degranulation|positive regulation of synaptic plasticity|vesicle docking involved in exocytosis	cytosol				endometrium(3)|kidney(2)|lung(3)|ovary(2)	10	all_cancers(89;0.004)|Renal(175;0.000269)|Lung NSC(126;0.00441)|all_lung(126;0.00747)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			AAAGCAGCCCTGGAGCAGCCC	0.657000													6	14					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35389649	35389649	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:35389649G>A	ENST00000311565.4	+	6	687	c.338G>A	c.(337-339)cGc>cAc	p.R113H	PPARD_ENST00000337400.2_Missense_Mutation_p.R113H|PPARD_ENST00000540939.1_Missense_Mutation_p.R10H|PPARD_ENST00000418635.2_Intron|PPARD_ENST00000448077.2_Missense_Mutation_p.R74H|PPARD_ENST00000444397.1_Missense_Mutation_p.R113H|PPARD_ENST00000360694.3_Missense_Mutation_p.R113H	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	113					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	AAGTGTGAGCGCAGCTGCAAG	0.567000													17	19					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205899137	205899137	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:205899137G>A	ENST00000367135.3	-	6	713	c.600C>T	c.(598-600)tcC>tcT	p.S200S	SLC26A9_ENST00000367134.2_Silent_p.S200S|SLC26A9_ENST00000340781.4_Silent_p.S200S	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	200						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TGAAGGACTCGGAGAGGTAGA	0.572000													7	6					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209104660	209104660	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:209104660C>A	ENST00000415913.1	-	8	1299	c.918G>T	c.(916-918)gaG>gaT	p.E306D	IDH1_ENST00000446179.1_Missense_Mutation_p.E306D|IDH1_ENST00000345146.2_Missense_Mutation_p.E306D			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	306					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		CGTGGGCAGCCTCTGCTTCTA	0.522000			Mis		gliobastoma								21	29					4.63292e-17	5.09502e-17	1	1	0
CNDP2	55748	broad.mit.edu	37	18	72178055	72178055	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:72178055C>A	ENST00000324262.4	+	6	780	c.464C>A	c.(463-465)cCt>cAt	p.P155H	CNDP2_ENST00000579847.1_Missense_Mutation_p.P155H|CNDP2_ENST00000324301.8_Missense_Mutation_p.P71H	NM_018235.2	NP_060705.2	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2 (metallopeptidase M20 family)	155						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(5)|ovary(2)|skin(2)|stomach(3)	24		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		CAGGAGATTCCTGTCAACGTC	0.498000													13	37					9.05144e-12	9.75833e-12	1	1	0
MPO	4353	broad.mit.edu	37	17	56349138	56349138	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56349138C>T	ENST00000340482.3	-	10	2180	c.2004G>A	c.(2002-2004)acG>acA	p.T668T	MPO_ENST00000225275.3_Silent_p.T636T			P05164	PERM_HUMAN	myeloperoxidase	636					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	TGTTGTTGGGCGTGCCATACT	0.622000													26	33					0	0	1	0	0
SH3BP2	6452	broad.mit.edu	37	4	2826453	2826453	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2826453G>A	ENST00000356331.5	+	4	614	c.353G>A	c.(352-354)cGc>cAc	p.R118H	SH3BP2_ENST00000515183.1_3'UTR|SH3BP2_ENST00000442312.2_Missense_Mutation_p.R146H|SH3BP2_ENST00000452765.2_Missense_Mutation_p.R118H|SH3BP2_ENST00000503393.2_Missense_Mutation_p.R175H|SH3BP2_ENST00000511747.1_Missense_Mutation_p.R118H|SH3BP2_ENST00000435136.2_Missense_Mutation_p.R118H	NM_003023.4	NP_003014.3	P78314	3BP2_HUMAN	SH3-domain binding protein 2	118	PH.				signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		GAGGAGGAGCGCAAGGTGACT	0.632000									Cherubism				14	19					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88584147	88584147	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:88584147G>T	ENST00000339673.6	+	6	1316	c.1217G>T	c.(1216-1218)aGc>aTc	p.S406I	DMP1_ENST00000282479.7_Missense_Mutation_p.S390I|RP11-742B18.1_ENST00000506480.1_RNA|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	406					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CAAGCAGACAGCGAATCCAGT	0.552000													22	24					9.95505e-16	1.0907e-15	1	1	0
NCKAP5L	57701	broad.mit.edu	37	12	50190190	50190190	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:50190190G>A	ENST00000335999.6	-	8	1654	c.1453C>T	c.(1453-1455)Cga>Tga	p.R485*		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	481	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CAGGGGATTCGCGAGTTCCGG	0.662000													5	7					0	0	1	0	0
MAP3K12	7786	broad.mit.edu	37	12	53880325	53880325	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53880325C>T	ENST00000267079.2	-	4	653	c.428G>A	c.(427-429)cGc>cAc	p.R143H	MAP3K12_ENST00000547488.1_Missense_Mutation_p.R176H|MAP3K12_ENST00000547035.1_Missense_Mutation_p.R176H|MAP3K12_ENST00000547151.1_5'UTR	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	143	Protein kinase.				histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						CCCGTGGAAGCGCCCCAGGAA	0.592000													7	14					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35714817	35714817	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35714817G>A	ENST00000314888.9	-	22	3164	c.2811C>T	c.(2809-2811)caC>caT	p.H937H	TLN1_ENST00000540444.1_Silent_p.H937H	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	937					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TAGAGGCTGCGTGCTGAGCTG	0.607000													4	57					0	0	1	0	0
SPTBN1	0	broad.mit.edu	37	2	54856594	54856594	+	Missense_Mutation	SNP	G	G	A	rs1804471		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:54856594G>A	ENST00000333896.5	+	13	2669	c.2284G>A	c.(2284-2286)Gat>Aat	p.D762N	SPTBN1_ENST00000356805.4_Missense_Mutation_p.D775N	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	775					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			CGTGGGCCACGATGAGTATTC	0.562000													34	26					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62298776	62298776	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62298776G>A	ENST00000378024.4	-	5	3387	c.3113C>T	c.(3112-3114)gCt>gTt	p.A1038V	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1038					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CAGATCTGGAGCATTAGTATC	0.463000													34	61					0	0	1	0	0
ARRDC4	91947	broad.mit.edu	37	15	98513233	98513233	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:98513233G>A	ENST00000268042.6	+	6	1167	c.1003G>A	c.(1003-1005)Gat>Aat	p.D335N	ARRDC4_ENST00000538249.1_Missense_Mutation_p.D248N	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	335					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			GTTCAGTATGGATATGAGCTG	0.428000													17	31					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77764474	77764474	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:77764474G>T	ENST00000354212.4	-	17	3148	c.2895C>A	c.(2893-2895)cgC>cgA	p.R965R	MAGI2_ENST00000419488.1_Silent_p.R951R|MAGI2_ENST00000522391.1_Silent_p.R965R	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	965	PDZ 5.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GTTTTGCACAGCGATCTGCAG	0.473000													25	56					3.73808e-20	4.14251e-20	1	1	0
TRIM33	51592	broad.mit.edu	37	1	114945490	114945490	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:114945490G>A	ENST00000358465.2	-	16	2867	c.2784C>T	c.(2782-2784)tgC>tgT	p.C928C	TRIM33_ENST00000369543.2_Silent_p.C928C|TRIM33_ENST00000450349.2_Silent_p.C560C	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	928					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACAAAATGTGCATATCCAGT	0.448000			T	RET	papillary thyroid								19	32					0	0	1	0	0
NARF	26502	broad.mit.edu	37	17	80439021	80439021	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80439021G>A	ENST00000390006.4	+	7	1000	c.526G>A	c.(526-528)Gct>Act	p.A176T	NARF_ENST00000412079.2_Missense_Mutation_p.A107T|NARF_ENST00000457415.3_Missense_Mutation_p.A281T|NARF_ENST00000345415.7_Missense_Mutation_p.A187T|NARF_ENST00000309794.10_Missense_Mutation_p.A235T	NM_001038618.2	NP_001033707.1	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor	235						lamin filament	lamin binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			GAAGCTGGAGGCTCTTCAGGA	0.582000													26	45					0	0	1	0	0
UHMK1	127933	broad.mit.edu	37	1	162469884	162469884	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:162469884G>A	ENST00000489294.1	+	2	566	c.408G>A	c.(406-408)caG>caA	p.Q136Q	UHMK1_ENST00000282169.8_3'UTR|UHMK1_ENST00000545294.1_Silent_p.Q62Q|UHMK1_ENST00000538489.1_Silent_p.Q136Q	NM_175866.4	NP_787062.1	Q8TAS1	UHMK1_HUMAN	U2AF homology motif (UHM) kinase 1	136	Protein kinase.				cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding			endometrium(1)|large_intestine(2)|lung(6)|prostate(2)	11	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			GGATGATACAGCATTGTGCCC	0.478000													45	42					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30308907	30308907	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:30308907T>C	ENST00000361371.4	-	26	4745	c.4595A>G	c.(4594-4596)gAg>gGg	p.E1532G	LTN1_ENST00000389194.2_Missense_Mutation_p.E1578G	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	1532							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						ATTTGGGACCTCAACTGCTGT	0.393000													73	38					0	0	1	0	0
AGBL5	60509	broad.mit.edu	37	2	27282314	27282314	+	Missense_Mutation	SNP	C	C	A	rs1058815		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27282314C>A	ENST00000323064.8	+	11	2293	c.2131C>A	c.(2131-2133)Ctg>Atg	p.L711M	AGBL5_ENST00000360131.4_Intron	NM_001035507.2	NP_001030584.1	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5	0					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	28	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTTCGGTTGTCTGGGGCATTG	0.557000													21	43					2.37509e-13	2.57931e-13	1	1	0
CLRN1	7401	broad.mit.edu	37	3	150644648	150644648	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:150644648G>A	ENST00000295911.2	-	4	745	c.354C>T	c.(352-354)ggC>ggT	p.G118G	RP11-166N6.3_ENST00000569170.1_Intron|RP11-166N6.2_ENST00000469268.1_RNA|CLRN1-AS1_ENST00000476886.1_RNA|CLRN1_ENST00000327047.1_3'UTR	NM_052995.2	NP_443721.1	P58418	CLRN1_HUMAN	clarin 1	0					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	14			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CTCAGCTGTGGCCTTTAGTCA	0.468000													14	22					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55735848	55735848	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:55735848T>C	ENST00000379906.2	+	13	2085		c.e13+2		SLC6A2_ENST00000568943.1_Splice_Site|SLC6A2_ENST00000566163.1_Splice_Site|SLC6A2_ENST00000567238.1_Splice_Site|SLC6A2_ENST00000219833.8_Splice_Site|SLC6A2_ENST00000414754.3_Splice_Site|SLC6A2_ENST00000561820.1_Intron	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2						synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	CAGTTCCAGGTGGGTGAAGCC	0.592000											OREG0023807	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	12					0	0	1	0	0
ANKRD23	200539	broad.mit.edu	37	2	97506646	97506646	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:97506646G>A	ENST00000318357.4	-	4	345	c.304C>T	c.(304-306)Cag>Tag	p.Q102*	ANKRD23_ENST00000418232.1_Nonsense_Mutation_p.Q102*|ANKRD23_ENST00000476975.1_5'UTR|ANKRD23_ENST00000331001.2_Intron	NM_144994.7	NP_659431.5	Q86SG2	ANR23_HUMAN	ankyrin repeat domain 23	102						nucleus				endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)	9						GCCTGGGACTGCGGCTGGTTC	0.592000													14	23					0	0	1	0	0
ARMC6	93436	broad.mit.edu	37	19	19162890	19162890	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19162890C>T	ENST00000535612.1	+	5	1171	c.739C>T	c.(739-741)Cgt>Tgt	p.R247C	ARMC6_ENST00000546344.1_Missense_Mutation_p.R154C|ARMC6_ENST00000392335.2_Missense_Mutation_p.R222C|ARMC6_ENST00000269932.6_Missense_Mutation_p.R222C|ARMC6_ENST00000392336.3_Missense_Mutation_p.R247C	NM_001199196.1	NP_001186125.1	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	247							protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|prostate(1)	14			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			CTGGGCCCTGCGTGTCATGAC	0.577000													11	20					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151860707	151860707	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:151860707C>A	ENST00000355193.2	-	43	10173	c.9955G>T	c.(9955-9957)Gtt>Ttt	p.V3319F	KMT2C_ENST00000262189.6_Missense_Mutation_p.V3319F					lysine (K)-specific methyltransferase 2C																		CCAGAAATAACTGTTGTGTGC	0.562000													17	22					1.02788e-11	1.10723e-11	1	1	0
SPECC1L	23384	broad.mit.edu	37	22	24761566	24761566	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:24761566G>A	ENST00000314328.9	+	13	3235	c.2950G>A	c.(2950-2952)Gca>Aca	p.A984T	KB-1896H10.1_ENST00000358654.2_3'UTR|SPECC1L_ENST00000541492.1_Missense_Mutation_p.A984T|SPECC1L_ENST00000437398.1_Missense_Mutation_p.A984T	NM_001254733.1|NM_015330.3	NP_001241662.1|NP_056145.3	Q69YQ0	CYTSA_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1-like	984					cell cycle|cell division					breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(3)|stomach(2)|urinary_tract(1)	27						TTCTCCAACGGCATCTGTGAC	0.507000													4	96					0	0	1	0	0
RBL1	5933	broad.mit.edu	37	20	35689594	35689594	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:35689594C>T	ENST00000373664.3	-	9	1228	c.1162G>A	c.(1162-1164)Gca>Aca	p.A388T	RBL1_ENST00000344359.3_Missense_Mutation_p.A388T	NM_002895.2	NP_002886.2	P28749	RBL1_HUMAN	retinoblastoma-like 1 (p107)	388	Domain A.|Pocket; binds T and E1A.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				GTGGCTGATGCAACAGGAGTA	0.413000													4	80					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72346077	72346077	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:72346077G>A	ENST00000299687.5	+	1	3102	c.3102G>A	c.(3100-3102)ctG>ctA	p.L1034L	ZNF407_ENST00000577538.1_Silent_p.L1034L|ZNF407_ENST00000309902.6_Silent_p.L1034L|ZNF407_ENST00000582337.1_Silent_p.L1034L	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1034					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CTCTAGAGCTGCATGTAAAAC	0.483000													27	65					0	0	1	0	0
ZNF652	22834	broad.mit.edu	37	17	47376203	47376203	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:47376203C>A	ENST00000362063.2	-	6	1711	c.1393G>T	c.(1393-1395)Ggc>Tgc	p.G465C	ZNF652_ENST00000430262.2_Missense_Mutation_p.G465C	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			GGCTTCTCGCCTGTGTGAGTT	0.537000													21	18					1.96292e-10	2.09789e-10	1	1	0
PCDHGB4	0	broad.mit.edu	37	5	140769586	140769586	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140769586G>A	ENST00000519479.1	+	1	2135	c.2135G>A	c.(2134-2136)cGc>cAc	p.R712H	PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1												p.R712H(1)		endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGCCTTGCGCCTGCGACGC	0.602000													68	120					0	0	1	0	0
NMRK1	54981	broad.mit.edu	37	9	77683992	77683992	+	Missense_Mutation	SNP	G	G	A	rs137952847		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:77683992G>A	ENST00000376811.1	-	8	890	c.428C>T	c.(427-429)tCt>tTt	p.S143F	NMRK1_ENST00000376808.4_Missense_Mutation_p.S115F|NMRK1_ENST00000361092.4_Missense_Mutation_p.S139F			Q9NWW6	NRK1_HUMAN	nicotinamide riboside kinase 1	139					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|ribosylnicotinamide kinase activity										GTATCCCGGAGAGTCTGGAGG	0.413000													18	33					0	0	1	0	0
CHM	1121	broad.mit.edu	37	X	85155679	85155679	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:85155679G>A	ENST00000357749.2	-	11	1414	c.1385C>T	c.(1384-1386)tCt>tTt	p.S462F	CHM_ENST00000537751.1_Missense_Mutation_p.S314F|CHM_ENST00000467744.1_Intron	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	462					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				TTTTAGGACAGATCTATCTGT	0.328000													17	1					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481945	123481945	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:123481945C>T	ENST00000280562.5	-	10	1604	c.1399G>A	c.(1399-1401)Gcc>Acc	p.A467T	PITPNM2_ENST00000392428.1_Missense_Mutation_p.A188T|PITPNM2_ENST00000320201.4_Missense_Mutation_p.A467T|PITPNM2_ENST00000542749.1_Missense_Mutation_p.A467T			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	467					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CGGCCCAGGGCGCTGGGGTAG	0.657000													31	44					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111400346	111400346	+	Silent	SNP	G	G	A	rs137868719	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:111400346G>A	ENST00000428084.1	-	40	4325	c.4053C>T	c.(4051-4053)taC>taT	p.Y1351Y	DOCK4_ENST00000437633.1_Silent_p.Y1342Y|DOCK4_ENST00000494651.2_Silent_p.Y225Y			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1342	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				CCAGCCTCTCGTAGTCATGCC	0.493000													4	115					0	0	1	0	0
PHC3	80012	broad.mit.edu	37	3	169889192	169889192	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:169889192A>G	ENST00000494943.1	-	4	415	c.347T>C	c.(346-348)gTc>gCc	p.V116A	PHC3_ENST00000467570.1_Missense_Mutation_p.V128A|PHC3_ENST00000481639.1_Missense_Mutation_p.V124A|PHC3_ENST00000474275.1_Missense_Mutation_p.V112A|PHC3_ENST00000497658.1_Missense_Mutation_p.V128A|PHC3_ENST00000495893.1_Missense_Mutation_p.V128A			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	116	Ser-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			CTGCTGTGTGACACTTCCTGT	0.343000													3	11					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150887067	150887067	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150887067G>A	ENST00000261800.5	-	22	12177	c.12165C>T	c.(12163-12165)gcC>gcT	p.A4055A		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	4055					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAACGCCACGGCCACTGTGA	0.572000													27	32					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728021	20728021	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:20728021T>C	ENST00000427401.4	-	4	1082	c.988A>G	c.(988-990)Aca>Gca	p.T330A		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	330					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						CTTTTATGTGTAGTAAGGACA	0.403000													7	56					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62153771	62153771	+	Missense_Mutation	SNP	C	C	T	rs142366357	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:62153771C>T	ENST00000474889.1	+	8	1344	c.967C>T	c.(967-969)Cgt>Tgt	p.R323C	PTPRG_ENST00000295874.10_Missense_Mutation_p.R323C	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	323					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		GTCCGCCGTCCGTGACTCCTG	0.522000													16	37					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41768203	41768203	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:41768203T>A	ENST00000379483.3	-	1	499	c.191A>T	c.(190-192)gAt>gTt	p.D64V		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	64	BTB.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		GATGGTCACATCACACAGCAG	0.607000													13	34					0	0	1	0	0
EXOSC9	5393	broad.mit.edu	37	4	122723045	122723045	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:122723045G>A	ENST00000512454.1	+	1	298	c.82G>A	c.(82-84)Gga>Aga	p.G28R	EXOSC9_ENST00000379663.3_Missense_Mutation_p.G44R|EXOSC9_ENST00000509980.1_3'UTR|EXOSC9_ENST00000243498.5_Missense_Mutation_p.G44R			Q06265	EXOS9_HUMAN	exosome component 9	44	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|urinary_tract(1)	16						AACAGATTACGGATGCTGCAT	0.373000													38	53					0	0	1	0	0
SIDT2	51092	broad.mit.edu	37	11	117063906	117063906	+	Missense_Mutation	SNP	G	G	A	rs138225019		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:117063906G>A	ENST00000324225.4	+	23	2674	c.2143G>A	c.(2143-2145)Gct>Act	p.A715T	SIDT2_ENST00000431081.2_Missense_Mutation_p.A712T|SIDT2_ENST00000532062.1_Missense_Mutation_p.A7T	NM_001040455.1	NP_001035545.1	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2	715						integral to membrane|lysosomal membrane				NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	36	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		CAATGATTTCGCTTCCTACTT	0.557000													7	396					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207175942	207175942	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:207175942C>T	ENST00000374423.3	+	5	7076	c.6690C>T	c.(6688-6690)taC>taT	p.Y2230Y		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2230							nucleic acid binding|zinc ion binding	p.Y2230*(1)		endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TTTCGAAATACTCTGTCTTTT	0.373000													10	8					0	0	1	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138710415	138710415	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:138710415C>T	ENST00000389532.4	-	13	4071	c.4007G>A	c.(4006-4008)cGg>cAg	p.R1336Q	CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.R1347Q|CAMSAP1_ENST00000312405.6_Missense_Mutation_p.R1058Q	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	1336						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GAGCTCGCGCCGCGCCTTCTC	0.632000													3	39					0	0	1	0	0
UQCC	0	broad.mit.edu	37	20	33935022	33935022	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:33935022C>T	ENST00000397554.1	-	7	528	c.518G>A	c.(517-519)cGt>cAt	p.R173H	UQCC_ENST00000542501.1_Silent_p.S129S|UQCC_ENST00000540457.1_Missense_Mutation_p.R18H|UQCC_ENST00000491125.1_5'UTR|UQCC_ENST00000349714.5_Missense_Mutation_p.R146H|UQCC_ENST00000359226.2_Intron|UQCC_ENST00000407996.2_Intron|UQCC_ENST00000397556.3_Missense_Mutation_p.R74H|UQCC_ENST00000374385.5_Missense_Mutation_p.R173H|UQCC_ENST00000374377.5_Missense_Mutation_p.R61H|UQCC_ENST00000374380.2_Missense_Mutation_p.R105H|UQCC_ENST00000374384.2_Missense_Mutation_p.R173H			Q9NVA1	UQCC_HUMAN		173						cytoplasmic membrane-bounded vesicle				breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	17			BRCA - Breast invasive adenocarcinoma(18;0.00252)			AACTATGATACGACACATGTA	0.478000													6	153					0	0	1	0	0
FAM92B	339145	broad.mit.edu	37	16	85135865	85135865	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:85135865G>A	ENST00000539556.1	-	7	761	c.606C>T	c.(604-606)agC>agT	p.S202S		NM_198491.1	NP_940893.1	Q6ZTR7	FA92B_HUMAN	family with sequence similarity 92, member B	202										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	16						TCTGGAAGGCGCTAGAATACA	0.463000													21	63					0	0	1	0	0
TMCO6	55374	broad.mit.edu	37	5	140023734	140023734	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140023734G>A	ENST00000394671.3	+	10	1256	c.1155G>A	c.(1153-1155)gaG>gaA	p.E385E	TMCO6_ENST00000537378.1_Silent_p.E145E|TMCO6_ENST00000252100.6_Silent_p.E391E|NDUFA2_ENST00000510680.1_Intron	NM_018502.3	NP_060972.3	Q96DC7	TMCO6_HUMAN	transmembrane and coiled-coil domains 6	385					protein import into nucleus	cytoplasm|nuclear pore	binding|protein transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(1)|urinary_tract(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTGATTGAGCCTCTCTTAC	0.488000													8	147					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63671554	63671554	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:63671554C>T	ENST00000402010.2	+	15	2190	c.1611C>T	c.(1609-1611)tcC>tcT	p.S537S	MARK2_ENST00000315032.8_Silent_p.S537S|MARK2_ENST00000413835.2_Intron|MARK2_ENST00000377810.3_Intron|MARK2_ENST00000361128.5_Intron|MARK2_ENST00000377809.4_Silent_p.S537S|MARK2_ENST00000508192.1_Intron|MARK2_ENST00000502399.3_Silent_p.S536S|MARK2_ENST00000350490.7_Intron|MARK2_ENST00000513765.2_Silent_p.S504S|MARK2_ENST00000509502.2_Silent_p.S503S|MARK2_ENST00000425897.2_Intron|MARK2_ENST00000408948.3_Intron	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	537					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						TGTCGGCCTCCGTGCACCCCA	0.687000													3	4					0	0	1	0	0
HPSE	10855	broad.mit.edu	37	4	84230632	84230632	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:84230632G>A	ENST00000405413.2	-	8	1043	c.907C>T	c.(907-909)Cgg>Tgg	p.R303W	HPSE_ENST00000512196.1_Missense_Mutation_p.R303W|HPSE_ENST00000311412.5_Missense_Mutation_p.R303W|HPSE_ENST00000513463.1_Missense_Mutation_p.R245W	NM_006665.5	NP_006656.2	Q9Y251	HPSE_HUMAN	heparanase	303					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	GTAGCAGTCCGTCCATTCAAA	0.299000													10	24					0	0	1	0	0
PRRC2B	84726	broad.mit.edu	37	9	134350236	134350236	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:134350236G>A	ENST00000357304.4	+	15	2775	c.2720G>A	c.(2719-2721)aGc>aAc	p.S907N	PRRC2B_ENST00000372249.1_5'UTR|PRRC2B_ENST00000458550.1_Intron|PRRC2B_ENST00000405995.1_Intron	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	907							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						AAGAACGGGAGCCCCAACAAA	0.662000													5	6					0	0	1	0	0
RARRES2	0	broad.mit.edu	37	7	150036112	150036112	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150036112C>T	ENST00000466675.1	-	3	1371	c.338G>A	c.(337-339)cGg>cAg	p.R113Q	RARRES2_ENST00000482669.1_Missense_Mutation_p.R113Q|RARRES2_ENST00000223271.3_Missense_Mutation_p.R113Q			Q99969	RARR2_HUMAN	retinoic acid receptor responder (tazarotene induced) 2	113					embryonic digestive tract development|in utero embryonic development|positive regulation of macrophage chemotaxis|retinoid metabolic process	extracellular matrix	receptor binding			endometrium(1)|large_intestine(1)|lung(1)|pancreas(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(82;0.011)			GTGGACCAACCGGCCCAGAAC	0.597000													27	57					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114136074	114136074	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:114136074G>A	ENST00000356116.1	+	1	119	c.7G>A	c.(7-9)Gct>Act	p.A3T	ACSL5_ENST00000354655.4_Intron|ACSL5_ENST00000393081.1_Intron|ACSL5_ENST00000433418.1_5'UTR|ACSL5_ENST00000479936.1_Intron|ACSL5_ENST00000354273.4_5'UTR	NM_016234.3	NP_057318.2	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	0					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		CTGCATGGACGCTCTGAAGCC	0.617000													21	37					0	0	1	0	0
RP11-468E2.4	0	broad.mit.edu	37	14	24626800	24626800	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24626800C>T	ENST00000558468.1	+	8	1105	c.1105C>T	c.(1105-1107)Cgc>Tgc	p.R369C	RNF31_ENST00000324103.6_Missense_Mutation_p.R894C|RNF31_ENST00000559275.1_Missense_Mutation_p.R743C|RNF31_ENST00000382687.3_Missense_Mutation_p.R743C																							TACCCAGTGCCGCCACCAGTT	0.587000													49	66					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11650904	11650904	+	Missense_Mutation	SNP	G	G	A	rs118160421	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:11650904G>A	ENST00000262442.3	+	32	6499	c.6431G>A	c.(6430-6432)cGg>cAg	p.R2144Q	DNAH9_ENST00000454412.2_Missense_Mutation_p.R2144Q	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2144	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTGGCTGTGCGGCACTCTGTA	0.592000													15	23					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68154117	68154117	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:68154117G>A	ENST00000294304.7	+	6	1455	c.1349G>A	c.(1348-1350)cGc>cAc	p.R450H		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	450	Beta-propeller 2.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GGCACCTCCCGCAAGATCCTG	0.701000													12	18					0	0	1	0	0
PAPOLG	64895	broad.mit.edu	37	2	61006774	61006774	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:61006774C>T	ENST00000238714.3	+	9	946	c.697C>T	c.(697-699)Cgt>Tgt	p.R233C	PAPOLG_ENST00000483370.1_3'UTR	NM_022894.3	NP_075045.2	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	233					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	35	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			TTTTCTAGGACGTGGTATTTA	0.373000													23	29					0	0	1	0	0
ZNF486	90649	broad.mit.edu	37	19	20308730	20308730	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:20308730A>G	ENST00000335117.8	+	4	1268	c.1211A>G	c.(1210-1212)aAa>aGa	p.K404R	CTC-260E6.6_ENST00000593655.1_RNA|CTC-260E6.6_ENST00000586657.1_RNA|CTC-260E6.6_ENST00000585498.1_RNA	NM_052852.3	NP_443084.2	Q96H40	ZN486_HUMAN	zinc finger protein 486	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11						ACTGGAGAGAAACCCTACAAA	0.388000													24	32					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28913388	28913388	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:28913388G>A	ENST00000395503.4	+	16	2489	c.2305G>A	c.(2305-2307)Gtg>Atg	p.V769M	ATP2A1_ENST00000357084.3_Missense_Mutation_p.V769M|ATP2A1_ENST00000536376.1_Missense_Mutation_p.V644M	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	769					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						TTCCTCCAACGTGGGCGAGGT	0.617000													11	23					0	0	1	0	0
ZNF607	84775	broad.mit.edu	37	19	38190090	38190090	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38190090G>A	ENST00000355202.4	-	5	1537	c.942C>T	c.(940-942)tgC>tgT	p.C314C	CTD-2528L19.4_ENST00000586606.2_Intron|ZNF607_ENST00000395835.3_Silent_p.C313C	NM_032689.4	NP_116078.4	Q96SK3	ZN607_HUMAN	zinc finger protein 607	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|lung(8)|urinary_tract(1)	27			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			AGCCCTTCCCGCATTCCTTGC	0.398000													33	75					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046505	42046505	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:42046505G>A	ENST00000372584.1	-	3	4978	c.3964C>T	c.(3964-3966)Cgt>Tgt	p.R1322C	HIVEP3_ENST00000429157.2_Missense_Mutation_p.R1322C|HIVEP3_ENST00000372583.1_Missense_Mutation_p.R1322C|HIVEP3_ENST00000247584.5_Missense_Mutation_p.R1322C	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1322					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GTCTGAACACGGACAGGCACA	0.602000													13	26					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71095090	71095090	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:71095090C>T	ENST00000283228.2	-	7	1473	c.1021G>A	c.(1021-1023)Gta>Ata	p.V341I	PTPRR_ENST00000378778.1_Missense_Mutation_p.V135I|PTPRR_ENST00000549308.1_Missense_Mutation_p.V96I|PTPRR_ENST00000440835.2_Missense_Mutation_p.V96I|PTPRR_ENST00000342084.4_Missense_Mutation_p.V229I	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	341					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GTAAGAGATACGTTGGACCCT	0.408000													36	53					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40364195	40364195	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:40364195C>T	ENST00000221347.6	-	31	14454	c.14447G>A	c.(14446-14448)cGc>cAc	p.R4816H		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4816						extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACACTCACAGCGCCGCTCACA	0.662000													6	27					0	0	1	0	0
LPHN1	22859	broad.mit.edu	37	19	14270291	14270291	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:14270291C>T	ENST00000340736.6	-	11	2257	c.1960G>A	c.(1960-1962)Gtc>Atc	p.V654I	CTB-55O6.12_ENST00000592086.1_RNA|LPHN1_ENST00000361434.3_Missense_Mutation_p.V649I|CTB-55O6.12_ENST00000588387.1_RNA	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	654					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TCCTCCAGGACGTCGAGGAGC	0.637000													8	16					0	0	1	0	0
JAZF1	221895	broad.mit.edu	37	7	27872571	27872571	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:27872571C>T	ENST00000283928.5	-	5	745	c.580G>A	c.(580-582)Gct>Act	p.A194T	JAZF1_ENST00000466516.1_5'UTR|TAX1BP1_ENST00000488564.1_Intron	NM_175061.3	NP_778231.2	Q86VZ6	JAZF1_HUMAN	JAZF zinc finger 1	194					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcriptional repressor complex	nucleic acid binding|transcription corepressor activity|zinc ion binding		JAZF1/SUZ12(133)	endometrium(1)|large_intestine(1)|lung(4)	6						CCATTCTTAGCGTGATACTTT	0.443000			T	SUZ12	endometrial stromal tumours								16	31					0	0	1	0	0
ABHD17B	51104	broad.mit.edu	37	9	74489562	74489562	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:74489562G>A	ENST00000333421.6	-	2	546	c.435C>T	c.(433-435)gaC>gaT	p.D145D	ABHD17B_ENST00000377041.2_Silent_p.D145D	NM_001025780.1	NP_001020951.1			abhydrolase domain containing 17B																		CAGCTTCAATGTCTGCATAGA	0.378000													16	51					0	0	1	0	0
ZNF142	7701	broad.mit.edu	37	2	219503083	219503083	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219503083G>A	ENST00000411696.2	-	9	5822	c.5043C>T	c.(5041-5043)ccC>ccT	p.P1681P	ZNF142_ENST00000449707.1_Silent_p.P1681P			P52746	ZN142_HUMAN	zinc finger protein 142	1681					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GTCCAGTGTGGGGAGCGGCAG	0.627000													7	11					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36051292	36051292	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36051292C>T	ENST00000262623.3	-	6	788	c.760G>A	c.(760-762)Gcc>Acc	p.A254T		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	254					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GAGAAGAAGGCGATGTTGCGG	0.627000													21	44					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116207736	116207736	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:116207736C>T	ENST00000369252.4	-	15	1759	c.1458G>A	c.(1456-1458)aaG>aaA	p.K486K	ABLIM1_ENST00000369266.3_Silent_p.K223K|ABLIM1_ENST00000533213.2_Silent_p.K486K|ABLIM1_ENST00000277895.5_Silent_p.K546K|ABLIM1_ENST00000392952.3_Silent_p.K223K|ABLIM1_ENST00000369253.2_Silent_p.K169K	NM_001003407.1|NM_001003408.1	NP_001003407.1|NP_001003408.1	O14639	ABLM1_HUMAN	actin binding LIM protein 1	546					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		ACTTGGAAAACTTGATGATAT	0.542000													13	41					0	0	1	0	0
TPP1	1200	broad.mit.edu	37	11	6638248	6638248	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6638248G>A	ENST00000533371.1	-	0	714				TPP1_ENST00000534644.1_5'UTR|TPP1_ENST00000299427.6_Silent_p.D215D			O14773	TPP1_HUMAN	tripeptidyl peptidase I						bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		CAGAGCCCACGTCTTGTGAGG	0.587000													17	15					0	0	1	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85164690	85164690	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:85164690G>A	ENST00000448803.2	+	3	1556	c.1264G>A	c.(1264-1266)Gag>Aag	p.E422K	ZSCAN2_ENST00000538076.1_Intron|ZSCAN2_ENST00000546148.1_Missense_Mutation_p.E422K|ZSCAN2_ENST00000541040.1_Intron|ZSCAN2_ENST00000327179.6_Missense_Mutation_p.E421K|ZSCAN2_ENST00000358472.3_Missense_Mutation_p.E272K|ZSCAN2_ENST00000485222.2_Intron	NM_181877.3	NP_870992.2	Q7Z7L9	ZSCA2_HUMAN	zinc finger and SCAN domain containing 2	422					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|liver(2)|lung(4)|ovary(1)|pancreas(1)	19				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		CCAGTGCAGCGAGTGTGGGAA	0.567000													8	44					0	0	1	0	0
TXNRD1	7296	broad.mit.edu	37	12	104721433	104721433	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104721433C>T	ENST00000526691.1	+	11	1688	c.1232C>T	c.(1231-1233)gCa>gTa	p.A411V	TXNRD1_ENST00000526950.1_Missense_Mutation_p.A428V|TXNRD1_ENST00000526390.1_Missense_Mutation_p.A403V|TXNRD1_ENST00000525566.1_Missense_Mutation_p.A509V|TXNRD1_ENST00000524698.1_Missense_Mutation_p.A359V|TXNRD1_ENST00000503506.2_Missense_Mutation_p.A359V|TXNRD1_ENST00000427956.1_Missense_Mutation_p.A474V|TXNRD1_ENST00000397736.2_Missense_Mutation_p.A403V|TXNRD1_ENST00000388854.3_Missense_Mutation_p.A411V|TXNRD1_ENST00000378070.4_Missense_Mutation_p.A458V|TXNRD1_ENST00000354940.6_Missense_Mutation_p.A359V|TXNRD1_ENST00000542918.1_Missense_Mutation_p.A409V|TXNRD1_ENST00000540716.1_Missense_Mutation_p.A321V|TXNRD1_ENST00000529546.1_Missense_Mutation_p.A321V|TXNRD1_ENST00000429002.2_Missense_Mutation_p.A509V	NM_001261445.1|NM_003330.3	NP_001248374.1|NP_003321.3	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	509					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						AGGCTCTATGCAGGTTCCACT	0.488000													9	12					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52429586	52429586	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52429586G>A	ENST00000420323.2	+	70	11412	c.11151G>A	c.(11149-11151)atG>atA	p.M3717I		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3782	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AAGCCATGATGCGCAGCTCCA	0.637000													12	30					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2959037	2959037	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2959037G>T	ENST00000396946.4	-	18	2882	c.2479C>A	c.(2479-2481)Ctg>Atg	p.L827M		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	827					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CCCATATCCAGGTCATGGTCT	0.612000			Mis		DLBCL								18	20					0.00887093	0.00896369	1	1	0
LAMA4	3910	broad.mit.edu	37	6	112443257	112443257	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:112443257G>A	ENST00000230538.7	-	32	4832	c.4435C>T	c.(4435-4437)Cgc>Tgc	p.R1479C	LAMA4_ENST00000389463.4_Missense_Mutation_p.R1472C|LAMA4_ENST00000424408.2_Missense_Mutation_p.R1472C|LAMA4_ENST00000522006.1_Missense_Mutation_p.R1472C	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	1479	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		AACTCTTGGCGGCTGTTGGCT	0.458000													32	65					0	0	1	0	0
NFKB1	4790	broad.mit.edu	37	4	103500131	103500131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:103500131C>T	ENST00000226574.4	+	8	1132	c.665C>T	c.(664-666)cCg>cTg	p.P222L	NFKB1_ENST00000600343.1_Missense_Mutation_p.P41L|NFKB1_ENST00000510638.1_3'UTR|NFKB1_ENST00000505458.1_Missense_Mutation_p.P221L|NFKB1_ENST00000394820.4_Missense_Mutation_p.P221L	NM_001165412.1|NM_003998.3	NP_001158884.1|NP_003989.2	P19838	NFKB1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	221	RHD.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			biliary_tract(1)|breast(4)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	GCTTTTCTTCCGGATAGCACT	0.547000													23	29					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14287024	14287024	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:14287024G>A	ENST00000344204.4	+	4	416	c.392G>A	c.(391-393)cGt>cAt	p.R131H	TRIO_ENST00000537187.1_Missense_Mutation_p.R131H|TRIO_ENST00000509967.2_Missense_Mutation_p.R82H	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	131	CRAL-TRIO.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GTGGACATGCGTGGGTCCAAG	0.557000													32	40					0	0	1	0	0
CD2AP	23607	broad.mit.edu	37	6	47512358	47512358	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:47512358G>T	ENST00000359314.5	+	4	792	c.336G>T	c.(334-336)caG>caT	p.Q112H		NM_012120.2	NP_036252.1	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	112	Interaction with ANLN and localization to the midbody.|SH3 2.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			AGAAGCGTCAGTGTAAAGTTC	0.308000													17	37					1.67942e-08	1.77343e-08	1	1	0
AIF1	199	broad.mit.edu	37	6	31583099	31583099	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31583099G>A	ENST00000376059.3	+	0	139					NM_001623.3	NP_001614.3	P55008	AIF1_HUMAN	allograft inflammatory factor 1						actin filament bundle assembly|cell cycle arrest|inflammatory response|negative regulation of cell proliferation	nucleus|ruffle membrane	actin filament binding|calcium ion binding			lung(2)|ovary(1)	3						ACCAGCATCTGCTGAGCTATG	0.572000													11	29					0	0	1	0	0
SLC19A1	6573	broad.mit.edu	37	21	46951819	46951819	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:46951819G>A	ENST00000311124.4	-	3	585	c.433C>T	c.(433-435)Cgg>Tgg	p.R145W	SLC19A1_ENST00000380010.4_Missense_Mutation_p.R145W|SLC19A1_ENST00000567670.1_Missense_Mutation_p.R145W|SLC19A1_ENST00000485649.2_Missense_Mutation_p.R105W	NM_194255.2	NP_919231.1	P41440	S19A1_HUMAN	solute carrier family 19 (folate transporter), member 1	145					folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		CGCGCGGGCCGCACGAGAGAG	0.672000													6	0					0	0	1	0	0
ENG	2022	broad.mit.edu	37	9	130578318	130578318	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130578318C>A	ENST00000344849.3	-	14	2036	c.1756G>T	c.(1756-1758)Ggc>Tgc	p.G586C	ENG_ENST00000373203.4_Missense_Mutation_p.G586C			P17813	EGLN_HUMAN	endoglin	586					artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	17						AGGACGAGGCCTTTGCTTGTG	0.632000									Juvenile Polyposis;Hereditary Hemorrhagic Telangiectasia				4	7					0.00024832	0.000253518	1	1	0
CHST1	8534	broad.mit.edu	37	11	45671748	45671748	+	Silent	SNP	C	C	T	rs111740567	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:45671748C>T	ENST00000308064.2	-	4	1396	c.726G>A	c.(724-726)tcG>tcA	p.S242S		NM_003654.5	NP_003645.1	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1	242					galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(10)|lung(17)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		TCTCGCTGCGCGAAGCCAGAA	0.657000													15	31					0	0	1	0	0
GPR153	387509	broad.mit.edu	37	1	6314106	6314106	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:6314106C>A	ENST00000377893.2	-	3	717	c.458G>T	c.(457-459)aGc>aTc	p.S153I		NM_207370.2	NP_997253.2	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	153						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|liver(1)|lung(7)|skin(1)	14	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)		GAAGCGCTCGCTGGTGTCGTG	0.632000													14	29					0.000219431	0.000224427	1	1	0
SETD1A	9739	broad.mit.edu	37	16	30992103	30992103	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30992103G>T	ENST00000262519.8	+	16	5311	c.4625G>T	c.(4624-4626)cGg>cTg	p.R1542L		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	1542					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						GAGCAGCGGCGGCTGCTGAGC	0.672000													16	23					8.00594e-06	8.29589e-06	1	1	0
DDOST	1650	broad.mit.edu	37	1	20987418	20987418	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:20987418T>C	ENST00000375048.3	-	2	377	c.272A>G	c.(271-273)gAa>gGa	p.E91G	DDOST_ENST00000415136.2_Intron|DDOST_ENST00000477229.1_5'UTR|DDOST_ENST00000602624.2_Missense_Mutation_p.E74G	NM_005216.4	NP_005207.2	P39656	OST48_HUMAN	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)	91					innate immune response|post-translational protein modification|response to cytokine stimulus|T cell activation	integral to membrane|microsome|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|skin(1)	13		all_lung(284;2.98e-05)|Lung NSC(340;3.25e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000141)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00046)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ATAGAGGAATTCCCCATACTT	0.507000													4	71					0	0	1	0	0
TRAM2	9697	broad.mit.edu	37	6	52380805	52380805	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:52380805G>A	ENST00000182527.3	-	4	409	c.411_splice	c.e4+1	p.T137_splice	EFHC1_ENST00000433625.2_Intron	NM_012288.3	NP_036420.1	Q15035	TRAM2_HUMAN	translocation associated membrane protein 2	137	TLC.				collagen biosynthetic process|protein transport|transmembrane transport	integral to membrane	protein binding			endometrium(3)|large_intestine(1)|lung(7)|prostate(1)|skin(1)	13	Lung NSC(77;0.109)					ATGGCTCACCGTCACCACCAC	0.498000													48	60					0	0	1	0	0
PTPN11	5781	broad.mit.edu	37	12	112924336	112924336	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112924336G>A	ENST00000351677.2	+	11	1480	c.1282G>A	c.(1282-1284)Gtg>Atg	p.V428M	PTPN11_ENST00000392597.1_Missense_Mutation_p.V428M	NM_002834.3	NP_002825.3	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type 11	432	Tyrosine-protein phosphatase.				axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding	p.V428M(1)		NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(406)|kidney(2)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(3)|stomach(3)	451						GGACCACGGCGTGCCCAGCGA	0.572000			Mis		"""JMML, AML, MDS"""		Noonan Syndrome		Noonan syndrome				13	14					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74605347	74605347	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74605347G>A	ENST00000361874.3	-	2	376	c.59C>T	c.(58-60)gCg>gTg	p.A20V	DCTN1_ENST00000394003.3_Missense_Mutation_p.A20V|DCTN1_ENST00000409567.3_Missense_Mutation_p.A20V|DCTN1_ENST00000409240.1_Missense_Mutation_p.A3V|DCTN1_ENST00000409868.1_Missense_Mutation_p.A3V	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	20					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						GCTTGCCTCCGCACTCATCCT	0.562000													14	26					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147967510	147967510	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:147967510T>C	ENST00000370460.2	+	8	1833	c.1354T>C	c.(1354-1356)Tac>Cac	p.Y452H	AFF2_ENST00000342251.3_Missense_Mutation_p.Y419H|AFF2_ENST00000370458.1_Missense_Mutation_p.Y413H|AFF2_ENST00000370457.5_Missense_Mutation_p.Y419H|AFF2_ENST00000286437.5_Missense_Mutation_p.Y93H	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	452					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CACTGAGCTCTACCAGGTTAG	0.502000													3	68					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38104200	38104200	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38104200T>C	ENST00000308059.6	+	5	1023	c.1002T>C	c.(1000-1002)ccT>ccC	p.P334P	DLEC1_ENST00000346219.3_Silent_p.P334P|DLEC1_ENST00000452631.2_Silent_p.P334P			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	334					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GTTTTTTTCCTCCTAACACTC	0.473000													13	31					0	0	1	0	0
SFRP5	6425	broad.mit.edu	37	10	99527606	99527606	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99527606G>A	ENST00000266066.3	-	3	737	c.619C>T	c.(619-621)Cgc>Tgc	p.R207C		NM_003015.3	NP_003006.2	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5	207	NTR.				apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding	p.R207C(2)		large_intestine(1)|lung(4)	5		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		TCCTTGATGCGCATTTTGACC	0.542000													31	69					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179641420	179641420	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179641420C>T	ENST00000589042.1	-	28	5395	c.5171G>A	c.(5170-5172)tGc>tAc	p.C1724Y	TTN_ENST00000342175.6_Missense_Mutation_p.C1678Y|TTN_ENST00000360870.5_Missense_Mutation_p.C1724Y|TTN_ENST00000591111.1_Missense_Mutation_p.C1724Y|TTN_ENST00000460472.2_Missense_Mutation_p.C1678Y|TTN_ENST00000342992.6_Missense_Mutation_p.C1724Y|TTN_ENST00000359218.5_Missense_Mutation_p.C1678Y	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1478	Ig-like 8.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTAGCCTGCATTCAAAGTG	0.453000													24	30					0	0	1	0	0
DNASE1	1773	broad.mit.edu	37	16	3707287	3707287	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3707287C>T	ENST00000246949.5	+	7	3858	c.649C>T	c.(649-651)Ctg>Ttg	p.L217L	DNASE1_ENST00000414110.2_Silent_p.L100L|DNASE1_ENST00000407479.1_Silent_p.L217L	NM_005223.3	NP_005214.2	P24855	DNAS1_HUMAN	deoxyribonuclease I	217					apoptosis|DNA catabolic process	extracellular region|nuclear envelope	actin binding|deoxyribonuclease I activity			lung(1)	1		Ovarian(90;0.0261)		Kidney(780;0.0556)	Dornase Alfa(DB00003)	CTTCCAGTGGCTGATCCCCGA	0.617000													17	14					0	0	1	0	0
ITGA10	8515	broad.mit.edu	37	1	145528630	145528630	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145528630G>A	ENST00000369304.3	+	5	602	c.427G>A	c.(427-429)Gcc>Acc	p.A143T	ITGA10_ENST00000538811.1_Intron|ITGA10_ENST00000539363.1_Intron	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	143					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGGGATATGTGCCCGTGTGGA	0.582000													10	31					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65483509	65483509	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:65483509A>G	ENST00000519389.1	+	20	3564	c.3385A>G	c.(3385-3387)Atc>Gtc	p.I1129V	HEPH_ENST00000374727.3_Missense_Mutation_p.I1078V|HEPH_ENST00000419594.1_Missense_Mutation_p.I886V|HEPH_ENST00000343002.2_Missense_Mutation_p.I1075V|HEPH_ENST00000336279.5_Missense_Mutation_p.I808V|HEPH_ENST00000441993.2_Missense_Mutation_p.I1078V			Q9BQS7	HEPH_HUMAN	hephaestin	1075					cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						TCTCACCGTCATCACCAAAGA	0.443000													32	5					0	0	1	0	0
STAG3L4	0	broad.mit.edu	37	7	66774022	66774022	+	RNA	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:66774022A>G	ENST00000416602.2	+	0	463					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				CGGTGCCAGTACATCCTCCTC	0.547000													25	36					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111694060	111694060	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:111694060G>A	ENST00000435970.1	-	15	6080	c.5264C>T	c.(5263-5265)gCc>gTc	p.A1755V	REV3L_ENST00000358835.3_Missense_Mutation_p.A1833V|REV3L_ENST00000368805.1_Missense_Mutation_p.A1833V|REV3L_ENST00000368802.3_Missense_Mutation_p.A1833V			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1833					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		ATCTTCACAGGCCACGTCTAC	0.418000								DNA polymerases (catalytic subunits)					54	85					0	0	1	0	0
PIPOX	51268	broad.mit.edu	37	17	27371958	27371958	+	Missense_Mutation	SNP	C	C	T	rs141823270		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27371958C>T	ENST00000323372.4	+	2	522	c.196C>T	c.(196-198)Cgg>Tgg	p.R66W	PIPOX_ENST00000583215.1_3'UTR	NM_016518.2	NP_057602.2	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	66					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity			endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	CTTTTACACCCGGATGATGCA	0.527000													16	24					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2535386	2535386	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:2535386G>A	ENST00000288709.6	-	11	1191	c.951C>T	c.(949-951)caC>caT	p.H317H	MMEL1_ENST00000378412.3_Silent_p.H326H|MMEL1_ENST00000502556.1_Silent_p.H169H	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	326					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CGATGACGTCGTGTCTCTCCT	0.677000													24	43					0	0	1	0	0
ZNF707	286075	broad.mit.edu	37	8	144776245	144776245	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144776245C>T	ENST00000532205.1	+	8	1560	c.661C>T	c.(661-663)Cgc>Tgc	p.R221C	ZNF707_ENST00000454097.1_Missense_Mutation_p.R221C|ZNF707_ENST00000532158.1_Missense_Mutation_p.R221C|ZNF707_ENST00000418203.2_Missense_Mutation_p.R221C|ZNF707_ENST00000358656.4_Missense_Mutation_p.R221C			Q96C28	ZN707_HUMAN	zinc finger protein 707	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;5.6e-41)|Epithelial(56;1.02e-39)|all cancers(56;9.65e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AAACCTGCAGCGCCACCAGAA	0.672000													6	9					0	0	1	0	0
RFX5	5993	broad.mit.edu	37	1	151316215	151316215	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151316215C>T	ENST00000290524.4	-	9	877	c.699G>A	c.(697-699)caG>caA	p.Q233Q	RFX5_ENST00000452513.2_Silent_p.Q193Q|RFX5_ENST00000452671.2_Silent_p.Q233Q|RFX5_ENST00000368870.2_Silent_p.Q233Q	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	233						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGATGAGATGCTGCTGTAGCA	0.587000													15	15					0	0	1	0	0
DBNDD1	79007	broad.mit.edu	37	16	90072796	90072796	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:90072796G>A	ENST00000392973.3	-	3	1173	c.442C>T	c.(442-444)Cag>Tag	p.Q148*	DBNDD1_ENST00000304733.3_Nonsense_Mutation_p.Q162*|DBNDD1_ENST00000002501.6_Nonsense_Mutation_p.Q142*|DBNDD1_ENST00000568838.1_Nonsense_Mutation_p.Q262*			Q9H9R9	DBND1_HUMAN	dysbindin (dystrobrevin binding protein 1) domain containing 1	142						cytoplasm				kidney(1)|large_intestine(1)|lung(1)	3		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0275)		ACTGTGGCCTGCCGCTCGGGG	0.682000													5	8					0	0	1	0	0
SFMBT1	51460	broad.mit.edu	37	3	52954553	52954553	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52954553C>T	ENST00000394752.3	-	12	1754	c.1372_splice	c.e12+1	p.V458_splice	SFMBT1_ENST00000296295.6_Splice_Site_p.V458_splice|SFMBT1_ENST00000394750.1_Splice_Site_p.V458_splice|SFMBT1_ENST00000358080.2_Splice_Site_p.V458_splice	NM_016329.3	NP_057413.2	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	458					regulation of transcription, DNA-dependent	nucleus				breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	24				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		AGACAGATACCTCGTGCTCGG	0.428000													5	10					0	0	1	0	0
DEPTOR	64798	broad.mit.edu	37	8	121015349	121015349	+	Splice_Site	SNP	C	C	T	rs145863430		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:121015349C>T	ENST00000286234.5	+	6	1054	c.925_splice	c.e6+1	p.S308_splice	DEPTOR_ENST00000518057.1_3'UTR|DEPTOR_ENST00000523492.1_Splice_Site_p.S207_splice	NM_022783.2	NP_073620.2	Q8TB45	DPTOR_HUMAN	DEP domain containing MTOR-interacting protein	308					intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	18						ACCCCAAGTCCGGTGAGTGCC	0.617000													7	13					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202625667	202625667	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:202625667C>T	ENST00000264276.6	-	4	1422	c.1050G>A	c.(1048-1050)cgG>cgA	p.R350R	ALS2_ENST00000467448.1_Silent_p.R350R	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	350					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						CTGACAGTTTCCGTAGGTATT	0.423000													24	43					0	0	1	0	0
FTO	79068	broad.mit.edu	37	16	53913791	53913791	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:53913791C>T	ENST00000471389.1	+	6	1233	c.1011C>T	c.(1009-1011)cgC>cgT	p.R337R	FTO_ENST00000394647.3_Silent_p.R41R	NM_001080432.2	NP_001073901.1	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	337					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						TTTTACAACGCTGTCAGTTGG	0.408000													32	54					0	0	1	0	0
DYX1C1	161582	broad.mit.edu	37	15	55727180	55727180	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:55727180G>A	ENST00000321149.3	-	8	1337	c.970C>T	c.(970-972)Cca>Tca	p.P324S	DYX1C1_ENST00000380679.1_Missense_Mutation_p.P324S|DYX1C1_ENST00000448430.2_Missense_Mutation_p.P324S|DYX1C1-CCPG1_ENST00000565113.1_RNA|DYX1C1_ENST00000457155.2_Missense_Mutation_p.P324S|DYX1C1_ENST00000348518.3_Missense_Mutation_p.P324S	NM_130810.3	NP_570722.2	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1	324					neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		TACAATAGTGGCATCTTATTA	0.333000													44	50					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169433371	169433371	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:169433371C>T	ENST00000261509.6	+	2	927	c.716C>T	c.(715-717)gCc>gTc	p.A239V	PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Missense_Mutation_p.A239V|PALLD_ENST00000333488.4_Missense_Mutation_p.A116V	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	239					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TCCCCTGGGGCCAGGCATTGC	0.602000									Pancreatic Cancer, Familial Clustering of				16	31					0	0	1	0	0
KCNQ1	3784	broad.mit.edu	37	11	2594154	2594154	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:2594154G>A	ENST00000155840.5	+	6	967	c.859G>A	c.(859-861)Gcg>Acg	p.A287T	KCNQ1_ENST00000335475.5_Missense_Mutation_p.A160T	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	287					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	TGAGAAGGACGCGGTGAACGA	0.592000													12	13					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27461327	27461327	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27461327G>A	ENST00000264705.4	+	31	5051	c.4889G>A	c.(4888-4890)cGg>cAg	p.R1630Q	CAD_ENST00000403525.1_Missense_Mutation_p.R1567Q	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1630	DHOase (dihydroorotase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCAAAGGCACGGGGCTTGCCA	0.597000													25	38					0	0	1	0	0
CRBN	51185	broad.mit.edu	37	3	3215789	3215789	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:3215789G>A	ENST00000231948.4	-	3	353	c.331C>T	c.(331-333)Cgg>Tgg	p.R111W	CRBN_ENST00000432408.2_Missense_Mutation_p.R110W	NM_016302.3	NP_057386.2	Q96SW2	CRBN_HUMAN	cereblon	111	Lon.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul4A-RING ubiquitin ligase complex|cytoplasm|membrane|nucleus	ATP-dependent peptidase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	11				Epithelial(13;0.00244)|OV - Ovarian serous cystadenocarcinoma(96;0.00617)|all cancers(10;0.0079)		ATTAAATTCCGCACCATACTG	0.408000													21	52					0	0	1	0	0
LDLRAD4	753	broad.mit.edu	37	18	13645640	13645640	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:13645640C>A	ENST00000361205.4	+	7	1573	c.905C>A	c.(904-906)cCt>cAt	p.P302H	LDLRAD4_ENST00000399848.3_Missense_Mutation_p.P284H|LDLRAD4_ENST00000586765.1_Missense_Mutation_p.P247H|RP11-701H16.4_ENST00000588397.1_RNA|LDLRAD4_ENST00000585931.1_Missense_Mutation_p.P225H|LDLRAD4_ENST00000587757.1_Missense_Mutation_p.P265H|LDLRAD4_ENST00000592991.1_Missense_Mutation_p.P204H|LDLRAD4_ENST00000359446.5_Missense_Mutation_p.P302H	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		GATAGGAAGCCTGGGAACCTG	0.547000													19	45					1.01871e-10	1.09092e-10	1	1	0
PRKAA2	5563	broad.mit.edu	37	1	57169922	57169922	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:57169922C>T	ENST00000371244.4	+	7	1133	c.1067C>T	c.(1066-1068)gCc>gTc	p.A356V		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	356					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						GATGATAGTGCCATGCATATT	0.463000													29	32					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167674683	167674683	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:167674683C>T	ENST00000519204.1	+	26	6494	c.6376C>T	c.(6376-6378)Cgc>Tgc	p.R2126C	TENM2_ENST00000403607.2_Missense_Mutation_p.R2071C|TENM2_ENST00000545108.1_Missense_Mutation_p.R2246C|TENM2_ENST00000520394.1_Missense_Mutation_p.R2008C|TENM2_ENST00000518659.1_Missense_Mutation_p.R2247C					teneurin transmembrane protein 2																		CATGCCCTTGCGCTATGACCT	0.547000													17	24					0	0	1	0	0
UPF1	5976	broad.mit.edu	37	19	18964097	18964097	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18964097G>A	ENST00000262803.5	+	8	1366	c.1094G>A	c.(1093-1095)cGg>cAg	p.R365Q	UPF1_ENST00000599848.1_Missense_Mutation_p.R376Q	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	376	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						ATATGCCTGCGGTACAAAGGG	0.572000													12	30					0	0	1	0	0
SC5D	6309	broad.mit.edu	37	11	121177112	121177112	+	Missense_Mutation	SNP	G	G	A	rs35536707		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:121177112G>A	ENST00000264027.4	+	4	735	c.361G>A	c.(361-363)Gtt>Att	p.V121I	SC5D_ENST00000534230.1_Missense_Mutation_p.V121I|SC5D_ENST00000528991.1_Intron|SC5D_ENST00000392789.2_Missense_Mutation_p.V121I	NM_006918.4	NP_008849.2			sterol-C5-desaturase																		TGAACTTGTCGTTAGTATAAT	0.378000													8	20					0	0	1	0	0
GRAMD2	196996	broad.mit.edu	37	15	72455632	72455632	+	Missense_Mutation	SNP	G	G	A	rs141361666	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:72455632G>A	ENST00000309731.7	-	10	944	c.931C>T	c.(931-933)Cgg>Tgg	p.R311W	GRAMD2_ENST00000564184.1_5'UTR	NM_001012642.2	NP_001012660.1	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	311						integral to membrane				cervix(2)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	13						TTGAGGAGCCGGTAATCCCAG	0.567000													7	24					0	0	1	0	0
PPIG	9360	broad.mit.edu	37	2	170493989	170493989	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:170493989G>A	ENST00000260970.3	+	14	2441	c.2221G>A	c.(2221-2223)Gat>Aat	p.D741N	PPIG_ENST00000448752.2_Missense_Mutation_p.D741N|PPIG_ENST00000409714.3_Missense_Mutation_p.D726N	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	741					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	TAAAAAATTTGATCATGAATC	0.333000													7	34					0	0	1	0	0
RMND5B	64777	broad.mit.edu	37	5	177565184	177565184	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:177565184G>A	ENST00000515098.1	+	4	415	c.64G>A	c.(64-66)Ggg>Agg	p.G22R	RMND5B_ENST00000313386.4_Missense_Mutation_p.G22R|RMND5B_ENST00000542098.1_Intron			Q96G75	RMD5B_HUMAN	required for meiotic nuclear division 5 homolog B (S. cerevisiae)	22										endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)	17	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTGACCTACGGGCAGCACTG	0.667000													4	11					0	0	1	0	0
ATP6V0D1	9114	broad.mit.edu	37	16	67472892	67472892	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67472892G>A	ENST00000290949.3	-	6	948	c.798C>T	c.(796-798)aaC>aaT	p.N266N	ATP6V0D1_ENST00000567694.1_5'UTR|ATP6V0D1_ENST00000540149.1_Silent_p.N307N|ATP6V0D1_ENST00000602876.1_Silent_p.N189N	NM_004691.4	NP_004682.2	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	266				NV -> KL (in Ref. 1; CAA50591).	ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex				large_intestine(3)|lung(3)|urinary_tract(2)	8		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		AATCGGCCACGTTCTTGACCT	0.617000													58	81					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75107502	75107502	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:75107502T>C	ENST00000290573.2	+	10	1976	c.1376T>C	c.(1375-1377)gTg>gCg	p.V459A	HK2_ENST00000409174.1_Missense_Mutation_p.V431A	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	459	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						GTGACAGCAGTGGCTTACCGG	0.617000													11	51					0	0	1	0	0
TMEM169	92691	broad.mit.edu	37	2	216965056	216965056	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:216965056G>A	ENST00000454545.1	+	4	1011	c.685G>A	c.(685-687)Gct>Act	p.A229T	TMEM169_ENST00000295658.4_Missense_Mutation_p.A229T|TMEM169_ENST00000437356.2_Missense_Mutation_p.A229T|TMEM169_ENST00000406027.2_Missense_Mutation_p.A229T	NM_001142310.1	NP_001135782.1	Q96HH4	TM169_HUMAN	transmembrane protein 169	229						integral to membrane				breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)	13		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGGCCTCTACGCTGCTGTGGT	0.577000													45	65					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86284577	86284577	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:86284577C>T	ENST00000394518.2	+	35	8004	c.7909C>T	c.(7909-7911)Cgg>Tgg	p.R2637W	AKAP13_ENST00000361243.2_Missense_Mutation_p.R2641W|AKAP13_ENST00000394510.2_Missense_Mutation_p.R882W|AKAP13_ENST00000560579.1_3'UTR	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2637	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GGAAAAGGAGCGGGAGGAGCT	0.652000													7	13					0	0	1	0	0
AC110615.1	0	broad.mit.edu	37	4	76871895	76871895	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:76871895C>T	ENST00000599764.1	+	1	13	c.13C>T	c.(13-15)Cca>Tca	p.P5S	SDAD1_ENST00000395711.4_3'UTR|SDAD1_ENST00000356260.5_3'UTR																							GGAAAACTTGCCAGGAAGTTA	0.353000													8	22					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57137383	57137383	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57137383G>A	ENST00000263314.2	+	12	1141	c.1107G>A	c.(1105-1107)gcG>gcA	p.A369A		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	369					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						TGAAAATCGCGGCTTTGACCA	0.547000													4	10					0	0	1	0	0
C9orf91	203197	broad.mit.edu	37	9	117400890	117400890	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:117400890G>T	ENST00000374049.4	+	8	1173	c.736G>T	c.(736-738)Gcg>Tcg	p.A246S	C9orf91_ENST00000288502.4_Missense_Mutation_p.A245S	NM_153045.3	NP_694590.2	Q5VZI3	CI091_HUMAN	chromosome 9 open reading frame 91	245						integral to membrane				endometrium(2)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	13						CCCTGCAACAGCGGAGGGGCC	0.557000													27	45					1.1804e-14	1.28927e-14	1	1	0
DNAJC13	23317	broad.mit.edu	37	3	132175576	132175576	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:132175576G>A	ENST00000260818.6	+	12	1497	c.1249G>A	c.(1249-1251)Gat>Aat	p.D417N	DNAJC13_ENST00000486798.1_3'UTR	NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	417							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						CCAAGAAGGGGATGTCGTTGC	0.433000													32	45					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87043586	87043586	+	Splice_Site	SNP	C	C	T	rs138241227	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:87043586C>T	ENST00000370563.3	+	12	1995	c.1951_splice	c.e12-1	p.G651_splice	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	651						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TATAACAAGGCGCTGATTCTT	0.373000													14	22					0	0	1	0	0
PARP10	84875	broad.mit.edu	37	8	145058757	145058757	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145058757G>A	ENST00000313028.7	-	5	1507	c.1413C>T	c.(1411-1413)gaC>gaT	p.D471D	PARP10_ENST00000525773.1_Silent_p.D483D|PARP10_ENST00000524918.1_Silent_p.D471D	NM_032789.3	NP_116178.2	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	471						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(2)	27	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGAGAGCGACGTCTCCCAGGC	0.617000													13	24					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	171956817	171956817	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:171956817G>A	ENST00000358155.4	+	3	433	c.257G>A	c.(256-258)tGc>tAc	p.C86Y	DNM3_ENST00000367731.1_Missense_Mutation_p.C86Y|DNM3_ENST00000520906.1_Missense_Mutation_p.C86Y|DNM3_ENST00000367733.2_Missense_Mutation_p.C86Y|DNM3_ENST00000355305.5_Missense_Mutation_p.C86Y	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	86					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TTTCTACATTGCAAAGGAAAG	0.323000													24	72					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99056478	99056478	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:99056478G>T	ENST00000357310.1	+	7	1426	c.849G>T	c.(847-849)gaG>gaT	p.E283D	APAF1_ENST00000551964.1_Missense_Mutation_p.E283D|APAF1_ENST00000359972.2_Missense_Mutation_p.E272D|APAF1_ENST00000552268.1_Missense_Mutation_p.E283D|APAF1_ENST00000339433.3_Missense_Mutation_p.E283D|APAF1_ENST00000550527.1_Missense_Mutation_p.E272D|APAF1_ENST00000547045.1_Missense_Mutation_p.E283D|APAF1_ENST00000549007.1_Missense_Mutation_p.E283D|APAF1_ENST00000333991.1_Missense_Mutation_p.E283D	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	283	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	TCCCTGTGGAGAGTTCCTTAG	0.294000													15	27					6.72482e-11	7.20828e-11	1	1	0
TNRC18	84629	broad.mit.edu	37	7	5413695	5413695	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:5413695G>T	ENST00000399537.4	-	10	3568	c.3220C>A	c.(3220-3222)Ctg>Atg	p.L1074M	TNRC18_ENST00000430969.1_Missense_Mutation_p.L1074M			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1074	Pro-rich.						DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CCTGAGAACAGGGCCTGGAAG	0.582000													9	17					1.12685e-05	1.16601e-05	1	1	0
AMHR2	269	broad.mit.edu	37	12	53818596	53818596	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53818596C>T	ENST00000257863.4	+	3	416	c.336C>T	c.(334-336)ggC>ggT	p.G112G	AMHR2_ENST00000379791.3_Silent_p.G112G|AMHR2_ENST00000550311.1_Silent_p.G112G	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	112					Mullerian duct regression		ATP binding|hormone binding|metal ion binding			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	GCTCCTGTGGCACTGACTTCT	0.642000													17	72					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4903590	4903590	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4903590G>A	ENST00000320785.5	+	3	406	c.49G>A	c.(49-51)Gcc>Acc	p.A17T		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	17	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						GCCCTTTAACGCCCGTGAGAC	0.627000													3	3					0	0	1	0	0
WNT5A	7474	broad.mit.edu	37	3	55504240	55504240	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:55504240G>A	ENST00000474267.1	-	6	1544	c.1023C>T	c.(1021-1023)ggC>ggT	p.G341G	WNT5A_ENST00000497027.1_Silent_p.G326G|WNT5A_ENST00000264634.4_Silent_p.G341G			P41221	WNT5A_HUMAN	wingless-type MMTV integration site family, member 5A	341					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(4)|lung(3)|prostate(2)|urinary_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		CGTAGCCACGGCCGCAGCACA	0.632000													32	50					0	0	1	0	0
DRG2	1819	broad.mit.edu	37	17	18001642	18001642	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18001642C>T	ENST00000225729.3	+	3	422	c.284C>T	c.(283-285)aCc>aTc	p.T95I	DRG2_ENST00000583355.1_Intron|DRG2_ENST00000395726.4_Missense_Mutation_p.T95I	NM_001388.4	NP_001379.1	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	95	G.				signal transduction		GTP binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	14	all_neural(463;0.228)					TATGAGTTCACCACTCTGACG	0.547000													25	152					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44799758	44799758	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44799758G>A	ENST00000309315.4	+	8	1125	c.1002G>A	c.(1000-1002)gaG>gaA	p.E334E	ZMIZ2_ENST00000433667.1_Silent_p.E302E|ZMIZ2_ENST00000441627.1_Silent_p.E334E|ZMIZ2_ENST00000413916.1_Intron|ZMIZ2_ENST00000265346.7_Intron	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	334	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						AGCCCACAGAGCAGTTCAACG	0.682000													13	18					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131261517	131261517	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:131261517C>T	ENST00000512055.1	-	19	3549	c.1423G>A	c.(1423-1425)Gct>Act	p.A475T	CPNE4_ENST00000429747.1_Missense_Mutation_p.A475T|CPNE4_ENST00000512332.1_Missense_Mutation_p.A493T|CPNE4_ENST00000511604.1_Missense_Mutation_p.A475T|CPNE4_ENST00000502818.1_Missense_Mutation_p.A493T			Q96A23	CPNE4_HUMAN	copine IV	475	VWFA.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						CTGAAGTCAGCGTTCCCTACT	0.562000													4	68					0	0	1	0	0
C12orf10	60314	broad.mit.edu	37	12	53700495	53700495	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53700495C>T	ENST00000267103.5	+	6	849	c.797C>T	c.(796-798)gCg>gTg	p.A266V	C12orf10_ENST00000549488.1_Missense_Mutation_p.A103V|C12orf10_ENST00000548632.1_Missense_Mutation_p.A191V	NM_021640.3	NP_067653.3	Q86UA3	Q86UA3_HUMAN	chromosome 12 open reading frame 10	266										cervix(1)|endometrium(3)|kidney(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	20						GTGGAACTGGCGAAAGGTGCA	0.517000													21	32					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77425417	77425417	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:77425417C>T	ENST00000560626.2	-	6	4482	c.4007G>A	c.(4006-4008)tGt>tAt	p.C1336Y	PEAK1_ENST00000312493.4_Missense_Mutation_p.C1336Y			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1336	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										ACCTGCCTCACAACATGGTTT	0.418000													28	36					0	0	1	0	0
HLA-F	3134	broad.mit.edu	37	6	29692036	29692036	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:29692036G>A	ENST00000440587.2	+	3	426	c.67G>A	c.(67-69)Ggc>Agc	p.G23S	HLA-F_ENST00000334668.4_Missense_Mutation_p.G141S|HLA-F_ENST00000259951.7_Missense_Mutation_p.G141S|HLA-F_ENST00000434407.2_Missense_Mutation_p.G141S|HLA-F_ENST00000376861.1_Missense_Mutation_p.G141S			P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	141	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8						CGCGTACGACGGCAAGGATTA	0.642000													16	48					0	0	1	0	0
RFX2	5990	broad.mit.edu	37	19	5997117	5997117	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5997117C>T	ENST00000303657.5	-	16	2116	c.1967G>A	c.(1966-1968)cGc>cAc	p.R656H	CTC-232P5.1_ENST00000587836.1_RNA|RFX2_ENST00000592546.1_Missense_Mutation_p.R631H|RFX2_ENST00000359161.3_Missense_Mutation_p.R656H	NM_000635.3	NP_000626.2	P48378	RFX2_HUMAN	regulatory factor X, 2 (influences HLA class II expression)	656					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.R656H(1)		breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						CTCCGCGACGCGGTGCTCCAC	0.682000													16	16					0	0	1	0	0
RRAGB	10325	broad.mit.edu	37	X	55777598	55777598	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:55777598G>A	ENST00000374941.4	+	6	1170	c.581G>A	c.(580-582)cGa>cAa	p.R194Q	RRAGB_ENST00000474757.1_3'UTR|RRAGB_ENST00000262850.7_Missense_Mutation_p.R222Q	NM_006064.4	NP_006055.3	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B	222					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding			breast(1)|endometrium(3)|large_intestine(5)|lung(3)|pancreas(1)|prostate(1)	14						TCTTGTTTCCGAACATCTATC	0.373000													18	5					0	0	1	0	0
LCMT1	51451	broad.mit.edu	37	16	25139801	25139801	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:25139801C>T	ENST00000399069.3	+	2	274	c.119C>T	c.(118-120)gCa>gTa	p.A40V	LCMT1_ENST00000380966.4_Missense_Mutation_p.A40V	NM_016309.2	NP_057393.2	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1	40							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity								GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	TCCAGGTTTGCAGTAAGCATT	0.478000													6	7					0	0	1	0	0
SLC2A8	29988	broad.mit.edu	37	9	130167748	130167748	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130167748C>A	ENST00000373371.3	+	9	1289	c.1200C>A	c.(1198-1200)atC>atA	p.I400I	SLC2A8_ENST00000373360.3_Intron|SLC2A8_ENST00000373352.1_Silent_p.I137I	NM_001271712.1|NM_014580.3	NP_001258641.1|NP_055395.2	Q9NY64	GTR8_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 8	400						cytoplasmic vesicle membrane|integral to plasma membrane	D-glucose transmembrane transporter activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	11						TGTCAGAGATCTTCCCTCTGC	0.622000													21	22					1.10513e-12	1.19686e-12	1	1	0
ADORA3	140	broad.mit.edu	37	1	112045933	112045933	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:112045933T>C	ENST00000241356.4	-	1	449	c.44A>G	c.(43-45)tAc>tGc	p.Y15C	ADORA3_ENST00000369717.4_Intron|ADORA3_ENST00000369716.4_Missense_Mutation_p.Y15C	NM_000677.3	NP_000668.1	P33765	AA3R_HUMAN	adenosine A3 receptor	15					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	CATGGTGATGTAGGTAACATT	0.547000													7	11					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96079848	96079848	+	Missense_Mutation	SNP	C	C	T	rs147707800	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:96079848C>T	ENST00000297954.4	+	29	6674	c.6674C>T	c.(6673-6675)gCg>gTg	p.A2225V	WNK2_ENST00000471076.1_3'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.A1837V|WNK2_ENST00000395477.2_Missense_Mutation_p.A2188V|WNK2_ENST00000356055.3_3'UTR|WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000427277.2_Missense_Mutation_p.A1800V			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	2225					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CTGCCCCCAGCGCCCGGCCCT	0.647000													9	11					0	0	1	0	0
RNF214	257160	broad.mit.edu	37	11	117152859	117152859	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:117152859G>A	ENST00000530849.1	+	10	1130	c.1120G>A	c.(1120-1122)Gcc>Acc	p.A374T	RNF214_ENST00000524917.1_Intron|RNF214_ENST00000531452.1_Missense_Mutation_p.A529T|RNF214_ENST00000300650.4_Missense_Mutation_p.A529T|RNF214_ENST00000531287.1_Missense_Mutation_p.A374T			Q8ND24	RN214_HUMAN	ring finger protein 214	529							zinc ion binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		GCCCCCTGCCGCCTCCATCCC	0.627000													39	47					0	0	1	0	0
KRTAP19-8	728299	broad.mit.edu	37	21	32410757	32410757	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:32410757G>A	ENST00000382822.2	-	1	38	c.6C>T	c.(4-6)agC>agT	p.S2S		NM_001099219.1	NP_001092689.1	Q3LI54	KR198_HUMAN	keratin associated protein 19-8	2						intermediate filament				endometrium(2)|upper_aerodigestive_tract(1)	3						TTCTGTAGTAGCTCATGGTTC	0.517000													37	18					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160482960	160482960	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:160482960G>A	ENST00000356956.1	+	25	3730	c.3582_splice	c.e25+1	p.S1194_splice		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1194					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CTCAGATATCGGTGTGTGTTC	0.488000													10	22					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	154010465	154010465	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:154010465G>A	ENST00000496811.1	-	15	1769	c.1689C>T	c.(1687-1689)gtC>gtT	p.V563V	DHX36_ENST00000544526.1_Silent_p.V549V|DHX36_ENST00000308361.6_Silent_p.V563V|DHX36_ENST00000329463.5_Silent_p.V549V	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	563	Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TCACATAAACGACATCATCTA	0.363000													18	52					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11022936	11022936	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:11022936G>A	ENST00000304623.8	-	17	3133	c.2944C>T	c.(2944-2946)Cgg>Tgg	p.R982W	CTNND2_ENST00000359640.2_Missense_Mutation_p.R924W|CTNND2_ENST00000503622.1_Missense_Mutation_p.R645W|CTNND2_ENST00000458100.2_Missense_Mutation_p.R549W|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000511377.1_Missense_Mutation_p.R891W	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	982					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CCGGCATCCCGTAAGGCCTTG	0.507000													22	37					0	0	1	0	0
PRR23C	389152	broad.mit.edu	37	3	138763018	138763018	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:138763018C>T	ENST00000413199.1	-	1	716	c.445G>A	c.(445-447)Gct>Act	p.A149T	PRR23C_ENST00000502927.2_Missense_Mutation_p.A149T|MRPS22_ENST00000495075.1_Intron	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	149										breast(2)|lung(7)|skin(2)	11						TCCTCGGCAGCGATCTCTGGG	0.667000													4	8					0	0	1	0	0
DUSP13	0	broad.mit.edu	37	10	76868940	76868940	+	Translation_Start_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:76868940C>A	ENST00000372702.3	-	0	39				DUSP13_ENST00000491677.2_De_novo_Start_OutOfFrame|DUSP13_ENST00000607131.1_De_novo_Start_OutOfFrame|DUSP13_ENST00000372700.3_De_novo_Start_OutOfFrame|DUSP13_ENST00000607009.1_5'UTR			Q6B8I1	MDSP_HUMAN	dual specificity phosphatase 13							cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	8	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					ACCCCTCTGCCTCTGTGGTCA	0.617000													4	14					1	1	1	1	0
EPHA8	2046	broad.mit.edu	37	1	22902839	22902839	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:22902839G>A	ENST00000166244.3	+	3	361	c.289G>A	c.(289-291)Gtc>Atc	p.V97I	EPHA8_ENST00000374644.4_Missense_Mutation_p.V97I|EPHA8_ENST00000538803.1_Missense_Mutation_p.V97I	NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	97						integral to plasma membrane	ATP binding|ephrin receptor activity	p.V97I(1)		breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CGCCCGGCGCGTCTATGCTGA	0.607000													13	32					0	0	1	0	0
MRAS	22808	broad.mit.edu	37	3	138121062	138121062	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:138121062G>A	ENST00000289104.4	+	6	1225	c.578G>A	c.(577-579)cGg>cAg	p.R193Q	MRAS_ENST00000464896.1_Missense_Mutation_p.R117Q|MRAS_ENST00000474559.1_Missense_Mutation_p.R193Q|MRAS_ENST00000423968.2_Missense_Mutation_p.R193Q	NM_001085049.2|NM_001252090.1|NM_001252091.1|NM_012219.4	NP_001078518.1|NP_001239019.1|NP_001239020.1|NP_036351.3	O14807	RASM_HUMAN	muscle RAS oncogene homolog	193					actin cytoskeleton organization|muscle organ development|Ras protein signal transduction	intracellular|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity			kidney(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	14						ACCAAATGGCGGGGAGACCGG	0.532000													3	13					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119027082	119027082	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:119027082A>G	ENST00000307417.3	+	7	1094	c.730A>G	c.(730-732)Aag>Gag	p.K244E	ABCG4_ENST00000531739.1_Missense_Mutation_p.K244E|ABCG4_ENST00000449422.2_Missense_Mutation_p.K244E	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	244	ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GTCCCTCATGAAGTCCCTGGC	0.587000													43	59					0	0	1	0	0
DYNC2LI1	51626	broad.mit.edu	37	2	44028050	44028050	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:44028050A>G	ENST00000260605.8	+	9	825	c.725A>G	c.(724-726)gAc>gGc	p.D242G	DYNC2LI1_ENST00000489222.2_3'UTR|DYNC2LI1_ENST00000605786.1_Missense_Mutation_p.D243G|DYNC2LI1_ENST00000443170.3_Missense_Mutation_p.D116G	NM_001193464.1|NM_016008.3	NP_001180393.1|NP_057092.2	Q8TCX1	DC2L1_HUMAN	dynein, cytoplasmic 2, light intermediate chain 1	242						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|skin(1)	26		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TTTGGCATTGACAAAAGGTAC	0.318000													4	41					0	0	1	0	0
ATG5	9474	broad.mit.edu	37	6	106727655	106727655	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:106727655G>A	ENST00000369076.3	-	5	682	c.359C>T	c.(358-360)gCa>gTa	p.A120V	ATG5_ENST00000369070.1_Missense_Mutation_p.A42V|ATG5_ENST00000343245.3_Missense_Mutation_p.A120V|ATG5_ENST00000360666.4_Intron	NM_004849.2	NP_004840.1	Q9H1Y0	ATG5_HUMAN	autophagy related 5	120					apoptosis|autophagic vacuole assembly|negative regulation of type I interferon production|post-translational protein modification	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			endometrium(1)|large_intestine(5)|lung(1)|prostate(1)	8	Breast(9;0.0296)	all_cancers(87;0.000301)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0612)|Lung NSC(302;0.216)	BRCA - Breast invasive adenocarcinoma(8;0.00802)	OV - Ovarian serous cystadenocarcinoma(136;0.128)|Epithelial(106;0.159)|all cancers(137;0.18)		AGCTTCAATTGCATCCTTAGA	0.313000													19	64					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67800963	67800963	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:67800963C>T	ENST00000544246.1	-	2	2301	c.1610G>A	c.(1609-1611)cGa>cAa	p.R537Q	PCDH9_ENST00000377861.3_Missense_Mutation_p.R537Q|PCDH9_ENST00000328454.5_Missense_Mutation_p.R537Q|PCDH9_ENST00000456367.1_Missense_Mutation_p.R537Q|PCDH9_ENST00000377865.2_Missense_Mutation_p.R537Q	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	537	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		AAAAATGAATCGTTCTTGTTC	0.463000													35	10					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11376008	11376008	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:11376008C>T	ENST00000315872.6	-	5	991	c.543G>A	c.(541-543)atG>atA	p.M181I		NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	181	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		CATAATTACTCATAAGGTTTA	0.388000													30	49					0	0	1	0	0
FAM104A	84923	broad.mit.edu	37	17	71228390	71228390	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:71228390C>T	ENST00000405159.3	-	1	120	c.56G>A	c.(55-57)gGg>gAg	p.G19E	FAM104A_ENST00000403627.3_Missense_Mutation_p.G19E|FAM104A_ENST00000583178.1_Intron|FAM104A_ENST00000581110.1_Missense_Mutation_p.G19E|C17orf80_ENST00000255557.4_5'UTR|FAM104A_ENST00000583024.1_Missense_Mutation_p.G19E	NM_001098832.1	NP_001092302.1	Q969W3	F104A_HUMAN	family with sequence similarity 104, member A	19										endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			LUSC - Lung squamous cell carcinoma(166;0.197)			TGGCGAGTACCCCTCAGTCGG	0.721000													14	35					0	0	1	0	0
L2HGDH	79944	broad.mit.edu	37	14	50750647	50750647	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:50750647G>A	ENST00000267436.4	-	5	1042	c.645C>T	c.(643-645)acC>acT	p.T215T	L2HGDH_ENST00000421284.3_Silent_p.T215T|L2HGDH_ENST00000555610.1_3'UTR|L2HGDH_ENST00000555423.1_Silent_p.T215T|L2HGDH_ENST00000261699.4_Silent_p.T215T			Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase	215					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			kidney(1)|large_intestine(4)|lung(3)|ovary(2)	10	all_epithelial(31;0.000599)|Breast(41;0.0102)					CTTCAAAATTGGTCAAGACAG	0.413000													36	61					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74415650	74415650	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:74415650G>A	ENST00000376332.3	-	7	1128	c.632C>T	c.(631-633)cCg>cTg	p.P211L	CHRDL2_ENST00000263671.5_Missense_Mutation_p.P211L|CHRDL2_ENST00000534159.1_5'UTR	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	211					cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					TGGGGTGCCCGGGCCTCTCTT	0.592000													11	14					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1499804	1499804	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:1499804C>T	ENST00000345913.4	+	12	2141	c.2050C>T	c.(2050-2052)Cgt>Tgt	p.R684C	TPO_ENST00000329066.4_Missense_Mutation_p.R684C|TPO_ENST00000382198.1_Missense_Mutation_p.R511C|TPO_ENST00000346956.3_Missense_Mutation_p.R684C|TPO_ENST00000349624.3_Missense_Mutation_p.R511C|TPO_ENST00000337415.3_Missense_Mutation_p.R684C|TPO_ENST00000382201.3_Missense_Mutation_p.R627C|TPO_ENST00000497517.2_Intron	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	684					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity	p.R684C(1)		breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGCACAGAGGCGTGAGCTGGA	0.577000													3	11					0	0	1	0	0
KRI1	65095	broad.mit.edu	37	19	10668529	10668529	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10668529G>A	ENST00000312962.6	-	15	1439	c.1420C>T	c.(1420-1422)Cgc>Tgc	p.R474C	KRI1_ENST00000361821.5_Missense_Mutation_p.R470C	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	474										NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GGGGCCTCGCGCTTTTTCTTC	0.687000													12	14					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144995788	144995788	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144995788G>A	ENST00000322810.4	-	32	8781	c.8612C>T	c.(8611-8613)gCg>gTg	p.A2871V	PLEC_ENST00000436759.2_Missense_Mutation_p.A2761V|PLEC_ENST00000398774.2_Missense_Mutation_p.A2702V|PLEC_ENST00000356346.3_Missense_Mutation_p.A2720V|PLEC_ENST00000357649.2_Missense_Mutation_p.A2738V|PLEC_ENST00000354589.3_Missense_Mutation_p.A2734V|PLEC_ENST00000527096.1_Missense_Mutation_p.A2757V|PLEC_ENST00000345136.3_Missense_Mutation_p.A2734V|PLEC_ENST00000354958.2_Missense_Mutation_p.A2712V	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2871	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCCTGAGGCCGCCTGCGCCTC	0.662000													6	32					0	0	1	0	0
HAPLN4	404037	broad.mit.edu	37	19	19371687	19371687	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19371687C>T	ENST00000291481.7	-	3	482	c.419G>A	c.(418-420)cGc>cAc	p.R140H	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	140	Ig-like C2-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			GCACTCATAGCGCCCGTAGTC	0.627000													8	52					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59112707	59112707	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:59112707G>A	ENST00000395153.3	+	4	1402	c.1255G>A	c.(1255-1257)Gcc>Acc	p.A419T	DACT1_ENST00000556859.1_Missense_Mutation_p.A175T|DACT1_ENST00000395151.3_Missense_Mutation_p.A175T|DACT1_ENST00000335867.4_Missense_Mutation_p.A456T|DACT1_ENST00000541264.2_Missense_Mutation_p.A175T	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	456					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						GCCAAAAACGGCCAAGCCAGC	0.607000													19	20					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151150562	151150562	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:151150562G>A	ENST00000474524.1	+	43	6446	c.6408G>A	c.(6406-6408)gtG>gtA	p.V2136V	MED12L_ENST00000273432.4_Silent_p.V1800V	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	2136					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGCAAGGAGTGACTCCGTATG	0.398000													8	38					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67579416	67579416	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67579416G>A	ENST00000540839.3	+	19	3446	c.3226G>A	c.(3226-3228)Gtg>Atg	p.V1076M	FAM65A_ENST00000428437.2_Missense_Mutation_p.V1071M|FAM65A_ENST00000042381.4_Missense_Mutation_p.V1057M|FAM65A_ENST00000379312.3_Missense_Mutation_p.V1061M|FAM65A_ENST00000422602.2_Missense_Mutation_p.V1077M			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	1061						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		GGAGGCCTACGTGACTGAGAC	0.627000													13	29					0	0	1	0	0
RSBN1	54665	broad.mit.edu	37	1	114354570	114354570	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:114354570C>T	ENST00000261441.5	-	1	528	c.465G>A	c.(463-465)ggG>ggA	p.G155G		NM_018364.3	NP_060834.2	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	155	Pro-rich.					nucleus				breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(3)|urinary_tract(2)	29	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGACAGCGGGCCCGGCGGGTG	0.716000													4	1					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106075068	106075068	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:106075068C>T	ENST00000278071.2	-	3	1194	c.742G>A	c.(742-744)Gcc>Acc	p.A248T	ITPRIP_ENST00000358187.2_Missense_Mutation_p.A248T|ITPRIP_ENST00000337478.1_Missense_Mutation_p.A248T	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	248						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						TCCCCATCGGCGCGGACCACC	0.667000													25	29					0	0	1	0	0
CHD1	1105	broad.mit.edu	37	5	98192225	98192225	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:98192225C>T	ENST00000284049.3	-	35	5141	c.4992G>A	c.(4990-4992)tgG>tgA	p.W1664*		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1664					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	GGTCCATTTGCCAGTCTGAGT	0.458000													4	38					0	0	1	0	0
TSTA3	7264	broad.mit.edu	37	8	144695126	144695126	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144695126T>C	ENST00000425753.2	-	11	1023	c.920A>G	c.(919-921)gAg>gGg	p.E307G	TSTA3_ENST00000529064.1_Missense_Mutation_p.E307G	NM_003313.3	NP_003304.1	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	307					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|skin(1)	9	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	AGCACAGGTCTCCTTCACCGC	0.657000													3	13					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14492825	14492825	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:14492825C>T	ENST00000344204.4	+	49	7806	c.7782C>T	c.(7780-7782)gcC>gcT	p.A2594A	TRIO_ENST00000344135.5_Silent_p.A93A|TRIO_ENST00000537187.1_Silent_p.A2418A	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2594	SH3 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TGTTCCGAGCCGCCACTGACC	0.567000													14	14					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47363955	47363955	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:47363955G>A	ENST00000285039.7	-	37	5369	c.5070C>T	c.(5068-5070)aaC>aaT	p.N1690N	MYO5B_ENST00000324581.6_Silent_p.N805N|SCARNA17_ENST00000589499.1_RNA|RP11-886H22.1_ENST00000590532.2_Silent_p.N13N|MYO5B_ENST00000592688.1_Silent_p.N260N	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1690	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GAGTCACTGCGTTGATCATGT	0.512000													11	28					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688246	60688246	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:60688246T>C	ENST00000335712.6	-	4	2028	c.1801A>G	c.(1801-1803)Act>Gct	p.T601A	BCL11A_ENST00000537768.1_Missense_Mutation_p.T270A|BCL11A_ENST00000356842.4_Missense_Mutation_p.T601A|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000358510.4_Missense_Mutation_p.T567A|BCL11A_ENST00000538214.1_Missense_Mutation_p.T567A	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	601					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CCATTAACAGTGCCATCGTCT	0.677000			T	IGH@	B-CLL								15	18					0	0	1	0	0
SDR9C7	121214	broad.mit.edu	37	12	57324035	57324035	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57324035C>T	ENST00000293502.1	-	2	678	c.535G>A	c.(535-537)Gtt>Att	p.V179I		NM_148897.2	NP_683695.1	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C, member 7	179						cytoplasm	binding|oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|pancreas(1)	7						AAGGCCTCAACGCCAAACTTG	0.547000													31	47					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36608563	36608563	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:36608563G>A	ENST00000265113.4	+	2	514	c.38G>A	c.(37-39)gGc>gAc	p.G13D	SLC1A3_ENST00000381918.3_Missense_Mutation_p.G13D|SLC1A3_ENST00000506725.1_3'UTR	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	13					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	AAGATGGGGGGCAGGATGGAG	0.448000													4	104					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128322879	128322879	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128322879C>T	ENST00000389524.4	+	4	257	c.204C>T	c.(202-204)gaC>gaT	p.D68D	MYO7B_ENST00000428314.1_Silent_p.D68D|MYO7B_ENST00000409816.2_Silent_p.D68D			Q6PIF6	MYO7B_HUMAN	myosin VIIB	68	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGGGTGTGGACGACATGATCC	0.592000													6	24					0	0	1	0	0
KLHL31	401265	broad.mit.edu	37	6	53520007	53520007	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:53520007C>T	ENST00000370905.3	-	2	204	c.64G>A	c.(64-66)Gta>Ata	p.V22I	KLHL31_ENST00000407079.1_Missense_Mutation_p.V22I	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	22					regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					CTATCTTCTACGATTATAGTC	0.408000													24	24					0	0	1	0	0
ACTN4	81	broad.mit.edu	37	19	39207768	39207768	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39207768C>T	ENST00000252699.2	+	10	1031	c.955C>T	c.(955-957)Cgt>Tgt	p.R319C	ACTN4_ENST00000390009.3_Missense_Mutation_p.R100C|ACTN4_ENST00000424234.2_Intron	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	319					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GCTGGAGGACCGTGTGCCCCA	0.642000													5	8					0	0	1	0	0
GPR141	353345	broad.mit.edu	37	7	37780645	37780645	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:37780645C>T	ENST00000447769.1	+	4	939	c.650C>T	c.(649-651)tCc>tTc	p.S217F	GPR141_ENST00000461610.1_Intron|GPR141_ENST00000334425.1_Missense_Mutation_p.S217F|EPDR1_ENST00000476620.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	217						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TCTTTACTATCCCACCAGGAG	0.413000													45	88					0	0	1	0	0
CDS2	8760	broad.mit.edu	37	20	5170424	5170424	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:5170424G>A	ENST00000460006.1	+	12	1452	c.1145G>A	c.(1144-1146)cGc>cAc	p.R382H	CDS2_ENST00000379070.3_3'UTR|CDS2_ENST00000379062.4_Missense_Mutation_p.R262H|CDS2_ENST00000535100.1_Missense_Mutation_p.R152H	NM_003818.3	NP_003809.1	O95674	CDS2_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2	382					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|stomach(1)	14						ATCATGGATCGCTTTGACTGC	0.478000													39	63					0	0	1	0	0
CFLAR	8837	broad.mit.edu	37	2	202025497	202025497	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:202025497C>T	ENST00000309955.2	+	9	1651	c.1136C>T	c.(1135-1137)gCg>gTg	p.A379V	CFLAR_ENST00000341582.6_Missense_Mutation_p.A344V|CFLAR_ENST00000457277.1_Missense_Mutation_p.A379V|CFLAR_ENST00000340870.5_Missense_Mutation_p.A379V|CFLAR_ENST00000355558.4_Intron|CFLAR_ENST00000423241.2_Missense_Mutation_p.A379V|CFLAR_ENST00000479953.2_Missense_Mutation_p.A283V|CFLAR_ENST00000443227.1_Missense_Mutation_p.A283V	NM_003879.5	NP_003870.4	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator	379	Interaction with TRAF1 and TRAF2.|Interaction with caspase-3.|Interaction with caspase-8 subunits p18 and p10.|Interaction with caspase-8.|Not proteolytically processed and involved in apoptosis inhibition.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|stomach(1)	13						GATGGGCCAGCGATGAAGAAT	0.527000													15	17					0	0	1	0	0
GNA14	9630	broad.mit.edu	37	9	80040627	80040627	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:80040627C>T	ENST00000341700.6	-	6	1241	c.728G>A	c.(727-729)cGc>cAc	p.R243H	GNA14_ENST00000464095.1_5'UTR	NM_004297.3	NP_004288.1	O95837	GNA14_HUMAN	guanine nucleotide binding protein (G protein), alpha 14	243					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity	p.R243H(1)		endometrium(3)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	24						CTCTTCCATGCGATTCTAAGT	0.413000													21	36					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242169568	242169568	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:242169568G>A	ENST00000391975.1	-	26	3818	c.3591_splice	c.e26+1	p.Y1197_splice	HDLBP_ENST00000391976.2_Splice_Site_p.Y1197_splice|HDLBP_ENST00000310931.4_Splice_Site_p.Y1197_splice|HDLBP_ENST00000427183.2_Splice_Site_p.Y1164_splice	NM_203346.3	NP_976221.1	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	1197	KH 14.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding	p.Y1197*(1)		breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		AGAGACTCACGTATTCCTCCT	0.627000													23	26					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111996574	111996574	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:111996574G>A	ENST00000305815.5	-	5	704	c.452C>T	c.(451-453)cCc>cTc	p.P151L	SLC9C1_ENST00000487372.1_Missense_Mutation_p.P151L	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	151					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										GGTTAGCATGGGATCTGAACT	0.318000													30	58					0	0	1	0	0
PHF2	5253	broad.mit.edu	37	9	96439899	96439899	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:96439899G>A	ENST00000359246.4	+	22	3599	c.3232G>A	c.(3232-3234)Gcc>Acc	p.A1078T	PHF2_ENST00000375376.4_Missense_Mutation_p.A309T	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	1078					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		CATGGCGACCGCCAAGCAGAG	0.537000													11	69					0	0	1	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135106570	135106570	+	Missense_Mutation	SNP	G	G	A	rs34832477	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:135106570G>A	ENST00000368563.2	-	7	1353	c.997C>T	c.(997-999)Cgc>Tgc	p.R333C	TUBGCP2_ENST00000252936.3_Missense_Mutation_p.R333C|TUBGCP2_ENST00000543663.1_Missense_Mutation_p.R361C|TUBGCP2_ENST00000417178.2_Missense_Mutation_p.R203C	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	333					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		TCCATGGTGCGCATGGCTGGC	0.637000													11	17					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167642259	167642259	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:167642259A>G	ENST00000519204.1	+	20	3815	c.3697A>G	c.(3697-3699)Acc>Gcc	p.T1233A	TENM2_ENST00000403607.2_Missense_Mutation_p.T1178A|TENM2_ENST00000545108.1_Missense_Mutation_p.T1353A|TENM2_ENST00000520394.1_Missense_Mutation_p.T1115A|TENM2_ENST00000518659.1_Missense_Mutation_p.T1354A					teneurin transmembrane protein 2																		CATAGATGCAACCCTGATGAG	0.542000													24	42					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9229987	9229987	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:9229987G>A	ENST00000318602.7	-	27	3613	c.3306C>T	c.(3304-3306)tcC>tcT	p.S1102S		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	1102					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	TGATATAGGCGGAGAGGGTCA	0.453000													10	12					0	0	1	0	0
MTM1	4534	broad.mit.edu	37	X	149787588	149787588	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:149787588C>T	ENST00000370396.2	+	6	474	c.420C>T	c.(418-420)taC>taT	p.Y140Y	MTM1_ENST00000306167.7_3'UTR|MTM1_ENST00000413012.2_Silent_p.Y103Y|MTM1_ENST00000543350.1_Silent_p.Y25Y|MTM1_ENST00000542741.1_Silent_p.Y45Y	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	140					endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					TCACGAGATACGCGTTTCCCC	0.512000													19	5					0	0	1	0	0
TBC1D2	55357	broad.mit.edu	37	9	101006409	101006409	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:101006409G>A	ENST00000375066.5	-	3	605	c.514C>T	c.(514-516)Caa>Taa	p.Q172*	TBC1D2_ENST00000375064.1_Nonsense_Mutation_p.Q172*|TBC1D2_ENST00000342112.5_5'UTR	NM_018421.3	NP_060891.3	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	172						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		GCCTCTTCTTGCCCTGGGAAC	0.582000													12	11					0	0	1	0	0
ARMC9	80210	broad.mit.edu	37	2	232079556	232079556	+	Missense_Mutation	SNP	G	G	A	rs144388331		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:232079556G>A	ENST00000349938.4	+	4	384	c.190G>A	c.(190-192)Gct>Act	p.A64T	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.3	NP_001258395.1|NP_079415.3	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	64							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		GGATCTTGTCGCTGCATTTGA	0.478000													12	36					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55569172	55569172	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:55569172G>A	ENST00000395445.1	-	36	5032	c.4638C>T	c.(4636-4638)ttC>ttT	p.F1546F	PCDH15_ENST00000395440.1_Silent_p.F480F|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395442.1_Silent_p.F411F|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395446.1_Silent_p.F742F|PCDH15_ENST00000395438.1_3'UTR	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AAATCATGGGGAATATTCTGG	0.423000										HNSCC(58;0.16)			20	29					0	0	1	0	0
GDI1	2664	broad.mit.edu	37	X	153669519	153669519	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153669519G>A	ENST00000447750.2	+	7	1131	c.796G>A	c.(796-798)Gtg>Atg	p.V266M		NM_001493.2	NP_001484.1	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	266					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	16	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGGCAAGGTGGTGGGCGTGAA	0.557000													36	14					0	0	1	0	0
FXR2	9513	broad.mit.edu	37	17	7496151	7496151	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7496151C>T	ENST00000250113.7	-	14	1924	c.1590G>A	c.(1588-1590)ccG>ccA	p.P530P		NM_004860.3	NP_004851.2	P51116	FXR2_HUMAN	fragile X mental retardation, autosomal homolog 2	530						cytosolic large ribosomal subunit	protein binding|RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)	26				READ - Rectum adenocarcinoma(115;0.17)		CTGAATCAACCGGGGGCTCTG	0.617000													10	22					0	0	1	0	0
CLEC18A	348174	broad.mit.edu	37	16	69996933	69996933	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:69996933G>T	ENST00000288040.6	+	11	1453	c.1266G>T	c.(1264-1266)caG>caT	p.Q422H	CLEC18A_ENST00000568461.1_Missense_Mutation_p.Q422H|CLEC18A_ENST00000393701.2_Missense_Mutation_p.Q422H|CLEC18A_ENST00000449317.2_Missense_Mutation_p.Q431H	NM_001136214.1|NM_001271197.1	NP_001129686.1|NP_001258126.1	A5D8T8	CL18A_HUMAN	C-type lectin domain family 18, member A	422	C-type lectin.					extracellular region	sugar binding			NS(1)|endometrium(2)|lung(1)|skin(1)	5						GGAACGACCAGCGCTGCAAAA	0.597000													4	48					7.48243e-07	7.8103e-07	1	1	0
TMEM194A	23306	broad.mit.edu	37	12	57454725	57454725	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57454725C>A	ENST00000300128.4	-	8	1007	c.984G>T	c.(982-984)aaG>aaT	p.K328N	TMEM194A_ENST00000379391.3_Missense_Mutation_p.K255N	NM_001130963.1	NP_001124435.1	O14524	T194A_HUMAN	transmembrane protein 194A	328						integral to membrane				endometrium(3)|large_intestine(3)|lung(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						CCTTACACACCTTTCTGTGCT	0.443000													21	27					5.35356e-11	5.74024e-11	1	1	0
IL17RA	23765	broad.mit.edu	37	22	17584433	17584433	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:17584433G>A	ENST00000319363.6	+	8	945	c.812G>A	c.(811-813)cGc>cAc	p.R271H		NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	271					fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		CTCACTCTACGCAACCTTAAA	0.557000													11	5					0	0	1	0	0
SSH3	54961	broad.mit.edu	37	11	67072293	67072293	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67072293G>A	ENST00000308127.4	+	3	332	c.154G>A	c.(154-156)Ggg>Agg	p.G52R	SSH3_ENST00000376757.5_Missense_Mutation_p.G52R|SSH3_ENST00000308298.7_Missense_Mutation_p.G52R|SSH3_ENST00000532181.1_3'UTR	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3	52					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCAGGATGGAGGGGACAATGA	0.617000													3	14					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428616	128428616	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:128428616C>A	ENST00000465342.2	+	2	1662	c.505C>A	c.(505-507)Ctc>Atc	p.L169I	CASC8_ENST00000501396.1_RNA|CASC8_ENST00000502082.1_RNA|CASC8_ENST00000523825.1_RNA|POU5F1B_ENST00000391675.1_Missense_Mutation_p.L169I			Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	169	POU-specific.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|prostate(1)|urinary_tract(1)	3						CGATGTGGGGCTCATCCTGGG	0.527000													4	10					0.00909568	0.00918626	1	1	0
ERBB2IP	55914	broad.mit.edu	37	5	65372215	65372215	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:65372215C>T	ENST00000284037.5	+	24	4424	c.4035C>T	c.(4033-4035)aaC>aaT	p.N1345N	ERBB2IP_ENST00000380935.1_Silent_p.N1235N|ERBB2IP_ENST00000380939.2_Silent_p.N1293N|ERBB2IP_ENST00000380936.1_Intron|ERBB2IP_ENST00000416865.2_Silent_p.N543N|ERBB2IP_ENST00000511297.1_Silent_p.N1300N|ERBB2IP_ENST00000380938.2_Silent_p.N1304N|ERBB2IP_ENST00000380943.2_Silent_p.N1304N|ERBB2IP_ENST00000503913.1_3'UTR|ERBB2IP_ENST00000506030.1_Silent_p.N1352N|ERBB2IP_ENST00000508515.1_Silent_p.N1235N	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	1345	PDZ.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		GTAGAGGAAACCCATTCAGAC	0.343000													21	36					0	0	1	0	0
KRTAP10-1	386677	broad.mit.edu	37	21	45960029	45960029	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:45960029G>A	ENST00000400375.1	-	1	49	c.5C>T	c.(4-6)gCc>gTc	p.A2V	TSPEAR_ENST00000397916.1_Intron|TSPEAR_ENST00000323084.4_Intron	NM_198691.2	NP_941964.2	P60331	KR101_HUMAN	keratin associated protein 10-1	2				A -> T (in Ref. 3; AAI20960).		keratin filament				breast(1)|central_nervous_system(1)|endometrium(1)|lung(3)|prostate(4)|skin(1)	11						GGTGGACGCGGCCATGCTGGG	0.637000													31	10					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003781	57003781	+	Missense_Mutation	SNP	C	C	T	rs147193169		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57003781C>T	ENST00000606794.1	-	1	894	c.698G>A	c.(697-699)cGc>cAc	p.R233H		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	233						integral to plasma membrane	G-protein coupled receptor activity	p.R233L(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						GCGTTCCTTGCGGAAGTGGCC	0.622000													17	19					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92472075	92472075	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:92472075C>T	ENST00000267622.4	-	11	2618	c.2245G>A	c.(2245-2247)Gca>Aca	p.A749T		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	749					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		AAATTACGTGCATTTGACAGT	0.358000			T	PDGFRB	AML								56	90					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33769058	33769058	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:33769058C>A	ENST00000285013.6	-	5	1721	c.1446G>T	c.(1444-1446)gaG>gaT	p.E482D	SLFN13_ENST00000533791.1_Missense_Mutation_p.E482D|SLFN13_ENST00000534689.1_Missense_Mutation_p.E164D|SLFN13_ENST00000526861.1_Missense_Mutation_p.E482D|SLFN13_ENST00000542635.1_Missense_Mutation_p.E482D|SLFN13_ENST00000360502.2_Missense_Mutation_p.E164D	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	482						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AGTCCTGGCCCTCTGCATCCT	0.552000													24	51					6.12954e-19	6.77144e-19	1	1	0
MERTK	10461	broad.mit.edu	37	2	112779082	112779082	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:112779082G>A	ENST00000295408.4	+	17	2530	c.2273G>A	c.(2272-2274)cGc>cAc	p.R758H	MERTK_ENST00000421804.2_Missense_Mutation_p.R758H|MERTK_ENST00000409780.1_Missense_Mutation_p.R582H			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	758	Protein kinase.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						CGCCAAGGCCGCATTGCTAAG	0.463000													32	44					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11217764	11217764	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:11217764C>T	ENST00000409790.1	+	21	2664	c.2434C>T	c.(2434-2436)Cgc>Tgc	p.R812C	CLEC16A_ENST00000465491.1_3'UTR|CLEC16A_ENST00000409552.3_Missense_Mutation_p.R794C	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	812								p.0?(1)		breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GGCCAAAGGCCGCATCCAGGC	0.602000													13	9					0	0	1	0	0
COPB1	1315	broad.mit.edu	37	11	14496079	14496079	+	Missense_Mutation	SNP	G	G	A	rs142993682		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:14496079G>A	ENST00000249923.3	-	14	1999	c.1699C>T	c.(1699-1701)Cgc>Tgc	p.R567C	COPB1_ENST00000439561.2_Missense_Mutation_p.R567C|COPB1_ENST00000526191.1_5'UTR	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	567					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						GCTACATAGCGCAATGCAATC	0.403000													32	45					0	0	1	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431825	56431825	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:56431825C>A	ENST00000302969.2	+	1	688	c.664C>A	c.(664-666)Ctt>Att	p.L222I		NM_001004730.1	NP_001004730.1	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(12)|prostate(1)|skin(3)|stomach(1)	26						TACCTTTATCCTTGTTGCAAT	0.478000													41	57					3.66854e-30	4.11036e-30	1	1	0
ZNF227	7770	broad.mit.edu	37	19	44740962	44740962	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44740962C>T	ENST00000313040.7	+	6	2584	c.2379C>T	c.(2377-2379)gtC>gtT	p.V793V	ZNF235_ENST00000589799.1_Intron|ZNF227_ENST00000391961.2_Silent_p.V742V|ZNF227_ENST00000589005.1_Silent_p.V742V	NM_182490.1	NP_872296.1	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	793					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(2)|stomach(1)|urinary_tract(1)	24		Prostate(69;0.0435)				ATCAGAAAGTCCATACTGGTA	0.403000													17	30					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155715	151155715	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:151155715C>T	ENST00000282466.3	-	6	6633	c.6634G>A	c.(6634-6636)Gta>Ata	p.V2212I	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2212	Ig-like C2-type 8.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCTACACATACGTACTCTCCA	0.418000													25	66					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100895199	100895199	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:100895199G>A	ENST00000369208.3	-	9	1725	c.943C>T	c.(943-945)Cac>Tac	p.H315Y	SIM1_ENST00000262901.4_Missense_Mutation_p.H315Y			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	315	PAC.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CGACTGTTGTGCACGATGGTC	0.597000													6	28					0	0	1	0	0
WRAP73	49856	broad.mit.edu	37	1	3551600	3551600	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:3551600C>A	ENST00000378322.3	-	8	835	c.777G>T	c.(775-777)acG>acT	p.T259T	WRAP73_ENST00000270708.7_Silent_p.T259T			Q9P2S5	WRP73_HUMAN	WD repeat containing, antisense to TP73	259						centrosome	protein binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|pancreas(1)	12						GCCCAAACTCCGTGATCATTT	0.567000													69	95					1.8615e-32	2.08843e-32	1	1	0
RAB30	27314	broad.mit.edu	37	11	82698794	82698794	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:82698794C>T	ENST00000533486.1	-	5	480	c.196G>A	c.(196-198)Gca>Aca	p.A66T	RAB30_ENST00000534141.1_Missense_Mutation_p.A66T|RAB30_ENST00000532548.1_Missense_Mutation_p.A66T|RAB30_ENST00000527633.1_Missense_Mutation_p.A66T|RP11-659G9.3_ENST00000527550.1_RNA|RAB30_ENST00000525117.1_Missense_Mutation_p.A38T|RAB30_ENST00000260056.2_Missense_Mutation_p.A66T	NM_014488.3	NP_055303.2	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	66					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						TCTTGACCTGCTGTGTCCCAG	0.443000													21	28					0	0	1	0	0
DCD	117159	broad.mit.edu	37	12	55038967	55038967	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:55038967G>A	ENST00000456047.2	-	4	468	c.279C>T	c.(277-279)agC>agT	p.S93S	DCD_ENST00000293371.6_Silent_p.S93S			P81605	DCD_HUMAN	dermcidin	93					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding	p.S93S(1)		large_intestine(2)|lung(2)|ovary(1)|skin(1)	6		Myeloproliferative disorder(1001;0.0255)				CTTTACCCACGCTTTCTAGAT	0.507000													39	56					0	0	1	0	0
MON1B	22879	broad.mit.edu	37	16	77229569	77229569	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:77229569T>C	ENST00000248248.3	+	5	1783	c.1433T>C	c.(1432-1434)cTa>cCa	p.L478P	MON1B_ENST00000545553.1_Missense_Mutation_p.L332P|MON1B_ENST00000439557.2_Missense_Mutation_p.L369P|MON1B_ENST00000320859.6_Missense_Mutation_p.Y142H	NM_014940.2	NP_055755.1	Q7L1V2	MON1B_HUMAN	MON1 secretory trafficking family member B	478							protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	17						AAGGAGACACTACTGGCCTGG	0.592000													3	41					0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183821199	183821199	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:183821199C>T	ENST00000360982.2	-	21	2920	c.2162G>A	c.(2161-2163)cGc>cAc	p.R721H	NCKAP1_ENST00000361354.3_Missense_Mutation_p.R715H	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	715					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CTTGGTAAAGCGTATTTCCAG	0.318000													39	85					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56247545	56247545	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:56247545G>A	ENST00000361673.3	-	4	676	c.463C>T	c.(463-465)Ccg>Tcg	p.P155S		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	155							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						GGAGTGCCCGGGGAGATGCTT	0.488000													44	63					0	0	1	0	0
GTF3C6	112495	broad.mit.edu	37	6	111288819	111288819	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:111288819C>T	ENST00000329970.7	+	6	678	c.468C>T	c.(466-468)gcC>gcT	p.A156A	GTF3C6_ENST00000480191.1_3'UTR	NM_138408.3	NP_612417.1	Q969F1	TF3C6_HUMAN	general transcription factor IIIC, polypeptide 6, alpha 35kDa	156						transcription factor TFIIIC complex	DNA binding|protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)	4		all_cancers(87;0.00328)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|Colorectal(196;0.0466)|all_epithelial(87;0.0575)		OV - Ovarian serous cystadenocarcinoma(136;0.105)|all cancers(137;0.179)|Epithelial(106;0.186)		TAGCTTCAGCCCCAGATAAAT	0.388000													47	65					0	0	1	0	0
COMP	1311	broad.mit.edu	37	19	18896317	18896317	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18896317G>T	ENST00000542601.2	-	14	1998	c.1609C>A	c.(1609-1611)Ctg>Atg	p.L537M	COMP_ENST00000425807.1_Missense_Mutation_p.L517M|COMP_ENST00000222271.2_Missense_Mutation_p.L570M			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	570	Mediates cell survival and induction of the IAP family of survival proteins.|TSP C-terminal.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding			breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						CCCACAGCCAGGCCTGGGTCG	0.667000													32	33					6.53348e-20	7.23485e-20	1	1	0
SYNDIG1L	646658	broad.mit.edu	37	14	74876313	74876313	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:74876313G>A	ENST00000331628.3	-	2	382	c.135C>T	c.(133-135)ggC>ggT	p.G45G	SYNDIG1L_ENST00000554823.1_Silent_p.G45G	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	45					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						CAGGCCCAGCGCCACCTAGGA	0.687000													13	14					0	0	1	0	0
CRLF3	51379	broad.mit.edu	37	17	29131012	29131012	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:29131012C>T	ENST00000324238.6	-	2	368	c.244G>A	c.(244-246)Gac>Aac	p.D82N	CRLF3_ENST00000544695.1_Intron	NM_015986.3	NP_057070.3	Q8IUI8	CRLF3_HUMAN	cytokine receptor-like factor 3	82					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of cell cycle arrest|positive regulation of JAK-STAT cascade|positive regulation of transcription from RNA polymerase II promoter	cytoplasm				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17		all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				TCAATGGTGTCCACCTCTTGC	0.473000													45	77					0	0	1	0	0
DGCR14	8220	broad.mit.edu	37	22	19126686	19126686	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19126686C>T	ENST00000252137.6	-	6	851	c.808G>A	c.(808-810)Gcc>Acc	p.A270T		NM_022719.2	NP_073210.1	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region gene 14	270					nervous system development	catalytic step 2 spliceosome				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	16	Colorectal(54;0.0993)					GCATTGAGGGCGGCTGCCTGC	0.637000													7	4					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55118841	55118841	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55118841C>T	ENST00000414150.2	+	3	520	c.242C>T	c.(241-243)cCc>cTc	p.P81L	MROH7_ENST00000545244.1_Intron|MROH7_ENST00000395690.2_Missense_Mutation_p.P81L|MROH7_ENST00000454855.2_Intron|MROH7_ENST00000472987.1_3'UTR|MROH7_ENST00000409996.1_Intron|MROH7_ENST00000421030.2_Missense_Mutation_p.P81L|MROH7_ENST00000339553.5_Missense_Mutation_p.P81L					maestro heat-like repeat family member 7																		GAAAACACCCCCAGACCTGAT	0.542000													23	39					0	0	1	0	0
FAM118B	79607	broad.mit.edu	37	11	126126745	126126745	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:126126745C>T	ENST00000533050.1	+	7	1473	c.980C>T	c.(979-981)tCa>tTa	p.S327L	FAM118B_ENST00000360194.4_Missense_Mutation_p.S327L	NM_024556.3	NP_078832.1	Q9BPY3	F118B_HUMAN	family with sequence similarity 118, member B	327										breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)	13	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		AGGGGTACATCAGGTAAGATG	0.438000													51	96					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76075500	76075500	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:76075500G>A	ENST00000395215.3	+	0	1140																											gagaggctgcgaaaggaggag	0.607000													7	205					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40757540	40757540	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:40757540G>A	ENST00000216194.7	+	9	967	c.911G>A	c.(910-912)tGc>tAc	p.C304Y	ADSL_ENST00000480775.1_3'UTR|ADSL_ENST00000454266.2_Missense_Mutation_p.C318Y|ADSL_ENST00000342312.6_Missense_Mutation_p.C304Y	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	304					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						TCAGAACGTTGCTGCAGTCTT	0.522000													46	57					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41585332	41585332	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:41585332G>T	ENST00000402685.2	+	2	729	c.721G>T	c.(721-723)Ggt>Tgt	p.G241C		NM_001164595.1	NP_001158067.1	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	241	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TATTATAGGAGGTCGACCAAA	0.303000													15	27					0.000422831	0.000430994	1	1	0
ATRNL1	26033	broad.mit.edu	37	10	117061448	117061448	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:117061448G>A	ENST00000355044.3	+	17	2839	c.2713G>A	c.(2713-2715)Gag>Aag	p.E905K	ATRNL1_ENST00000423111.2_Missense_Mutation_p.E2K	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	905	PSI 4.					integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CAATGGCATGGAGTGTATGTG	0.433000													23	40					0	0	1	0	0
CXCR5	643	broad.mit.edu	37	11	118765271	118765271	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118765271C>T	ENST00000292174.4	+	2	1194	c.1018C>T	c.(1018-1020)Ctg>Ttg	p.L340L	BCL9L_ENST00000334801.3_3'UTR	NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	340					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		CCTGACGAAGCTGGGCTGTAC	0.622000													15	31					0	0	1	0	0
GDF11	0	broad.mit.edu	37	12	56143335	56143335	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56143335G>A	ENST00000257868.5	+	3	930	c.893G>A	c.(892-894)cGg>cAg	p.R298Q		NM_005811.3	NP_005802.1	O95390	GDF11_HUMAN	growth differentiation factor 11	298					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|urinary_tract(1)	12						CGTTCCCGGCGGAACCTGGGT	0.557000													48	44					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43088557	43088557	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:43088557C>T	ENST00000359467.3	-	5	1955	c.1841G>A	c.(1840-1842)tGt>tAt	p.C614Y	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	614						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						GGTTTTTCCACATTCATTACA	0.363000													34	53					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55038847	55038847	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:55038847C>T	ENST00000474759.1	+	32	2796	c.2748C>T	c.(2746-2748)ggC>ggT	p.G916G	CACNA2D3_ENST00000288197.5_Silent_p.G916G|CACNA2D3_ENST00000415676.2_Silent_p.G916G|CACNA2D3_ENST00000478261.1_3'UTR|CACNA2D3_ENST00000490478.1_Silent_p.G822G	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	916						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GCAGCGATGGCGCCCATGGCC	0.453000													22	22					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19349134	19349134	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19349134C>T	ENST00000252575.5	+	11	3366	c.3323C>T	c.(3322-3324)gCa>gTa	p.A1108V	NCAN_ENST00000538881.1_Missense_Mutation_p.A559V	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1108	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			CACCGGAGGGCATGGGAAGAT	0.627000													22	24					0	0	1	0	0
CES1	1066	broad.mit.edu	37	16	55862745	55862745	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:55862745C>A	ENST00000422046.2	-	2	472	c.191G>T	c.(190-192)aGg>aTg	p.R64M	CES1_ENST00000360526.3_Missense_Mutation_p.R65M|CES1_ENST00000361503.4_Missense_Mutation_p.R64M			P23141	EST1_HUMAN	carboxylesterase 1	64				R -> G (in Ref. 18; CAA37147).	response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	TGGAGTAAACCTCAGGGGTCC	0.542000													5	15					0.00116845	0.0011864	1	1	0
TTC14	151613	broad.mit.edu	37	3	180322340	180322340	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:180322340C>A	ENST00000412756.2	+	5	715	c.646C>A	c.(646-648)Cta>Ata	p.L216I	TTC14_ENST00000296015.4_Missense_Mutation_p.L216I|TTC14_ENST00000382584.4_Missense_Mutation_p.L216I	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	216							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TCCACCACACCTATCTGGTAT	0.333000													16	70					2.31682e-05	2.39009e-05	1	1	0
RALGAPB	57148	broad.mit.edu	37	20	37194073	37194073	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:37194073G>A	ENST00000262879.6	+	25	4053	c.3769G>A	c.(3769-3771)Gcc>Acc	p.A1257T	RALGAPB_ENST00000397038.1_Missense_Mutation_p.A1036T|RALGAPB_ENST00000397040.1_Missense_Mutation_p.A1257T|RALGAPB_ENST00000397042.3_Missense_Mutation_p.A1254T			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	1257	Rap-GAP.				activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TTATGCTGATGCCCTTACAGA	0.383000													51	83					0	0	1	0	0
ISLR2	57611	broad.mit.edu	37	15	74425163	74425163	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:74425163C>T	ENST00000361742.3	+	4	837	c.68C>T	c.(67-69)cCg>cTg	p.P23L	ISLR2_ENST00000565540.1_Missense_Mutation_p.P23L|ISLR2_ENST00000561975.1_Intron|ISLR2_ENST00000419208.1_Missense_Mutation_p.P23L|ISLR2_ENST00000435464.1_Missense_Mutation_p.P23L|ISLR2_ENST00000445793.1_Missense_Mutation_p.P23L|ISLR2_ENST00000453268.2_Missense_Mutation_p.P23L|ISLR2_ENST00000565159.1_Missense_Mutation_p.P23L	NM_001130136.1|NM_020851.2	NP_001123608.1|NP_065902.1	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing leucine-rich repeat 2	23	LRRNT.				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane				breast(3)|endometrium(6)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36						TGCCCGGAGCCGTGCGCCTGC	0.627000													20	27					0	0	1	0	0
TSTA3	7264	broad.mit.edu	37	8	144697027	144697027	+	Missense_Mutation	SNP	C	C	T	rs149496415		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144697027C>T	ENST00000425753.2	-	4	423	c.320G>A	c.(319-321)cGc>cAc	p.R107H	TSTA3_ENST00000529064.1_Missense_Mutation_p.R107H	NM_003313.3	NP_003304.1	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	107					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|skin(1)	9	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	CACCACCTTGCGGGCGCCCAC	0.627000													11	15					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210971047	210971047	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:210971047C>T	ENST00000367007.4	-	9	1806	c.1637G>A	c.(1636-1638)cGc>cAc	p.R546H	KCNH1_ENST00000271751.4_Missense_Mutation_p.R573H	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	573					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GAACACCTTGCGGTTCAGGTG	0.617000													4	35					0	0	1	0	0
ZNF281	23528	broad.mit.edu	37	1	200377605	200377605	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:200377605C>T	ENST00000294740.2	-	2	1353	c.1229G>A	c.(1228-1230)aGc>aAc	p.S410N	ZNF281_ENST00000367352.3_Missense_Mutation_p.S374N|ZNF281_ENST00000367353.1_Missense_Mutation_p.S410N	NM_012482.3	NP_036614.1	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	410					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	27						AATAGCTATGCTTTTTGACTT	0.368000													41	66					0	0	1	0	0
FOXP4	116113	broad.mit.edu	37	6	41545742	41545742	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:41545742C>T	ENST00000373060.1	+	3	681	c.223C>T	c.(223-225)Cag>Tag	p.Q75*	FOXP4_ENST00000307972.4_Nonsense_Mutation_p.Q75*|FOXP4_ENST00000373063.3_Nonsense_Mutation_p.Q75*|FOXP4_ENST00000409208.1_Nonsense_Mutation_p.Q75*|FOXP4_ENST00000373057.3_Nonsense_Mutation_p.Q75*	NM_001012426.1|NM_001012427.1	NP_001012426.1|NP_001012427.1	Q8IVH2	FOXP4_HUMAN	forkhead box P4	75	Gln-rich.				embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)					AGTGGCCCGGCAGTTCCTGCT	0.617000													5	11					0	0	1	0	0
KAZN	23254	broad.mit.edu	37	1	15382647	15382647	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:15382647C>T	ENST00000376030.2	+	5	1081	c.787C>T	c.(787-789)Ccg>Tcg	p.P263S	KAZN_ENST00000361144.5_Missense_Mutation_p.P257S|KAZN_ENST00000422387.2_Missense_Mutation_p.P263S|KAZN_ENST00000400797.3_Missense_Mutation_p.P169S|KAZN_ENST00000400798.2_Missense_Mutation_p.P169S|KAZN_ENST00000503743.1_Missense_Mutation_p.P263S	NM_201628.2	NP_963922.2	Q674X7	KAZRN_HUMAN	kazrin, periplakin interacting protein	263	Interaction with PPL.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus				central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(1)|prostate(2)	25						CCTCGCCATGCCGGGCGAGAC	0.597000													4	37					0	0	1	0	0
CARD16	114769	broad.mit.edu	37	11	104916042	104916042	+	Translation_Start_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:104916042C>A	ENST00000375704.3	-	0	61				CASP1_ENST00000598974.1_Intron|CASP1_ENST00000594519.1_Intron|CASP1_ENST00000593315.1_Intron|CARD16_ENST00000525374.1_Intron|CASP1_ENST00000415981.2_Intron|CARD16_ENST00000375706.2_5'UTR	NM_052889.2	NP_443121.1			caspase recruitment domain family, member 16											endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	11						CTCTCCTACCCTTCTTGTGTG	0.483000													47	66					2.52991e-16	2.77867e-16	1	1	0
PITX2	5308	broad.mit.edu	37	4	111539338	111539338	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:111539338C>T	ENST00000354925.2	-	7	2602	c.897G>A	c.(895-897)gtG>gtA	p.V299V	PITX2_ENST00000394598.2_Silent_p.V299V|PITX2_ENST00000306732.3_Silent_p.V306V|PITX2_ENST00000355080.5_Silent_p.V253V|PITX2_ENST00000394595.3_3'UTR	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	299					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CCGGGTTCTGCACGCTGGCGT	0.627000													14	21					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72138254	72138254	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:72138254A>G	ENST00000555818.1	+	8	3022	c.2674A>G	c.(2674-2676)Aca>Gca	p.T892A	SIPA1L1_ENST00000358550.2_Missense_Mutation_p.T892A|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.T892A|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.T367A	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	892					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TGAACAGGAAACAAAGAGCGT	0.453000													31	56					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23889638	23889638	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:23889638G>A	ENST00000532292.1	-	1	1537	c.1443C>T	c.(1441-1443)aaC>aaT	p.N481N		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TATAGGCGTGGTTTTTGGTAT	0.423000													20	29					0	0	1	0	0
CBLN3	643866	broad.mit.edu	37	14	24897110	24897110	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24897110G>T	ENST00000267406.6	-	3	973	c.503C>A	c.(502-504)tCt>tAt	p.S168Y	CBLN3_ENST00000555436.1_Missense_Mutation_p.S117Y	NM_001039771.2	NP_001034860.1	Q6UW01	CBLN3_HUMAN	cerebellin 3 precursor	168	C1q.|Necessary for interaction with CBLN3, and homotrimerization (By similarity).					cell junction|extracellular region|synapse				central_nervous_system(1)|lung(3)	4				GBM - Glioblastoma multiforme(265;0.00159)		CAGTAGCACAGAGCTGGTGGC	0.607000													28	46					2.65835e-16	2.91848e-16	1	1	0
SDS	10993	broad.mit.edu	37	12	113836583	113836583	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:113836583G>A	ENST00000257549.4	-	4	384	c.262C>T	c.(262-264)Ccc>Tcc	p.P88S		NM_006843.2	NP_006834.2	P20132	SDHL_HUMAN	serine dehydratase	88					gluconeogenesis|L-serine catabolic process|pyruvate biosynthetic process	cytoplasm	L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|protein homodimerization activity|pyridoxal phosphate binding			large_intestine(2)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(1)	11					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GTGGTGCTGGGCACCACGATG	0.647000													15	13					0	0	1	0	0
WDR62	284403	broad.mit.edu	37	19	36594100	36594100	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36594100C>T	ENST00000401500.2	+	29	3540	c.3505C>T	c.(3505-3507)Cgc>Tgc	p.R1169C	WDR62_ENST00000270301.7_Missense_Mutation_p.R1164C	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	1164					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGAGGCCTGGCGCCCACCACG	0.682000													7	26					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144946589	144946589	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144946589C>T	ENST00000525985.1	-	2	904	c.833G>A	c.(832-834)cGg>cAg	p.R278Q				P58107	EPIPL_HUMAN	epiplakin 1	278						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CAGGTAGCGCCGCACCTCGGC	0.682000													10	11					0	0	1	0	0
NUMA1	0	broad.mit.edu	37	11	71725245	71725245	+	Missense_Mutation	SNP	C	C	T	rs140741340	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:71725245C>T	ENST00000393695.3	-	15	3635	c.3304G>A	c.(3304-3306)Gca>Aca	p.A1102T	NUMA1_ENST00000351960.6_Intron|NUMA1_ENST00000358965.6_Missense_Mutation_p.A1102T	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1102					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity	p.A1102T(1)		central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						GAGCCAGATGCGTGCTCCTTT	0.577000			T	RARA	APL								44	66					0	0	1	0	0
EEFSEC	60678	broad.mit.edu	37	3	127872522	127872522	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:127872522G>A	ENST00000254730.6	+	1	226	c.172G>A	c.(172-174)Gtg>Atg	p.V58M	RUVBL1_ENST00000464873.1_5'UTR|EEFSEC_ENST00000483457.1_Missense_Mutation_p.V58M	NM_021937.3	NP_068756.2	P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific	58						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						GTGCTTCTCGGTGCCGCTGCC	0.711000													3	8					0	0	1	0	0
GPR45	11250	broad.mit.edu	37	2	105858688	105858688	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:105858688C>A	ENST00000258456.1	+	1	489	c.373C>A	c.(373-375)Ctg>Atg	p.L125M		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	125						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						CGTGGCCATCCTGCTCATCAT	0.627000													15	17					4.14922e-12	4.48033e-12	1	1	0
PIK3R2	5296	broad.mit.edu	37	19	18279701	18279701	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18279701C>T	ENST00000593731.1	+	15	2534	c.1974C>T	c.(1972-1974)tcC>tcT	p.S658S	PIK3R2_ENST00000222254.7_Silent_p.S658S			O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	658	SH2 2.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(3)|pancreas(1)|stomach(1)	24						ACGCCTGCTCCGTGGTGTGAG	0.657000													3	3					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42643076	42643076	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:42643076C>T	ENST00000282030.5	+	6	4500	c.4204C>T	c.(4204-4206)Cgg>Tgg	p.R1402W		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	1402						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GTTCAAGCGGCGGGAGATCGA	0.532000									Schinzel-Giedion syndrome				4	29					0	0	1	0	0
EVI2A	2123	broad.mit.edu	37	17	29645977	29645977	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:29645977T>C	ENST00000247270.3	-	3	460	c.124A>G	c.(124-126)Aca>Gca	p.T42A	NF1_ENST00000356175.3_Intron|EVI2A_ENST00000461237.1_Missense_Mutation_p.T19A|NF1_ENST00000581113.2_Intron|EVI2A_ENST00000462804.2_Missense_Mutation_p.T19A|NF1_ENST00000358273.4_Intron	NM_001003927.2	NP_001003927.1	P22794	EVI2A_HUMAN	ecotropic viral integration site 2A	19						integral to membrane	transmembrane receptor activity	p.0?(8)|p.?(3)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	14		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;5.94e-13)|Epithelial(4;7.98e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.4e-12)|GBM - Glioblastoma multiforme(4;0.18)		AAAACTGTTGTCATCAGAAAG	0.413000													46	99					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28473394	28473394	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28473394C>T	ENST00000261609.7	-	35	5542	c.5434G>A	c.(5434-5436)Gcc>Acc	p.A1812T		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1812					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TGCGTGAGGGCCAGCATGCCG	0.552000													11	17					0	0	1	0	0
ZNF525	170958	broad.mit.edu	37	19	53884645	53884645	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53884645C>T	ENST00000467003.1	+	4	906	c.705C>T	c.(703-705)taC>taT	p.Y235Y	ZNF525_ENST00000593918.1_Intron|ZNF525_ENST00000475179.1_Intron|ZNF525_ENST00000474037.1_Silent_p.Y271Y					zinc finger protein 525											endometrium(3)|kidney(3)|lung(3)	9						AGAAACCTTACAAGTGTAATG	0.408000													36	52					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	985923	985923	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:985923G>A	ENST00000379370.2	+	29	5143	c.5093G>A	c.(5092-5094)cGc>cAc	p.R1698H		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1698	Laminin G-like 2.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CTGCGGGACCGCCGCCTGGAG	0.716000													21	29					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49159665	49159665	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49159665G>A	ENST00000418109.1	-	29	4876	c.4712C>T	c.(4711-4713)gCg>gTg	p.A1571V	LAMB2_ENST00000305544.4_Missense_Mutation_p.A1571V	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1571	Domain I.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGCCAGGATCGCATCCACATC	0.627000													14	16					0	0	1	0	0
APLF	200558	broad.mit.edu	37	2	68794512	68794512	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:68794512G>A	ENST00000303795.4	+	9	1497	c.1326G>A	c.(1324-1326)acG>acA	p.T442T	APLF_ENST00000471727.1_3'UTR	NM_173545.2	NP_775816.1	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	442					double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	25						GACATAATACGCTTCCAGGTA	0.284000													21	30					0	0	1	0	0
FAM20A	54757	broad.mit.edu	37	17	66538252	66538252	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:66538252G>A	ENST00000592554.1	-	7	1705	c.983C>T	c.(982-984)gCt>gTt	p.A328V	FAM20A_ENST00000226094.5_5'UTR|PRKAR1A_ENST00000588188.2_Intron	NM_001243746.1|NM_017565.3	NP_001230675.1|NP_060035.2	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	328						extracellular region				cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|stomach(1)	9	Breast(10;1.64e-13)					GCCACAGACAGCATACTCCGT	0.612000													16	16					0	0	1	0	0
NOP14	8602	broad.mit.edu	37	4	2948203	2948203	+	Missense_Mutation	SNP	G	G	A	rs114205498	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2948203G>A	ENST00000416614.2	-	11	1636	c.1571C>T	c.(1570-1572)gCg>gTg	p.A524V	NOP14_ENST00000502735.1_Missense_Mutation_p.A524V|NOP14-AS1_ENST00000503709.1_RNA|NOP14_ENST00000398071.4_Missense_Mutation_p.A524V|NOP14_ENST00000314262.6_Missense_Mutation_p.A524V|NOP14-AS1_ENST00000515194.1_RNA|NOP14-AS1_ENST00000505731.1_RNA|NOP14-AS1_ENST00000507702.1_RNA			P78316	NOP14_HUMAN	NOP14 nucleolar protein	524					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	30						CTCATGCATCGCATCTCGGAG	0.478000													9	33					0	0	1	0	0
TFAP2C	7022	broad.mit.edu	37	20	55211734	55211734	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:55211734G>A	ENST00000201031.2	+	6	1234	c.991G>A	c.(991-993)Gca>Aca	p.A331T	TFAP2C_ENST00000544508.1_Missense_Mutation_p.A162T	NM_003222.3	NP_003213.1	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	331	H-S-H (helix-span-helix), dimerization.				cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			Colorectal(105;0.229)			TAAACCAGTGGCAGAATATTT	0.438000													21	38					0	0	1	0	0
MFHAS1	9258	broad.mit.edu	37	8	8747722	8747722	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:8747722T>C	ENST00000276282.6	-	1	3433	c.2847A>G	c.(2845-2847)ttA>ttG	p.L949L		NM_004225.2	NP_004216.2	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified sequence 1	949										endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		ATATATTTGGTAATGATGCAT	0.517000													11	53					0	0	1	0	0
KBTBD3	143879	broad.mit.edu	37	11	105925166	105925166	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:105925166T>C	ENST00000526793.1	-	3	409	c.250A>G	c.(250-252)Aac>Gac	p.N84D	KBTBD3_ENST00000531837.1_Missense_Mutation_p.N84D|KBTBD3_ENST00000534815.1_Missense_Mutation_p.N5D	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	80	BTB.									NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TCTTTCATGTTTACTTCAAAC	0.303000													15	18					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110782460	110782460	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:110782460C>T	ENST00000282356.4	+	6	934	c.536C>T	c.(535-537)gCa>gTa	p.A179V	CAMK4_ENST00000512453.1_Missense_Mutation_p.A179V	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	179	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		GCCCCAGATGCACCACTCAAA	0.363000													19	31					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231264929	231264929	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:231264929T>C	ENST00000243810.6	+	15	1285	c.1285T>C	c.(1285-1287)Tgc>Cgc	p.C429R	SP140L_ENST00000415673.2_Missense_Mutation_p.C429R|SP140L_ENST00000396563.4_Missense_Mutation_p.C394R|SP140L_ENST00000444636.1_Missense_Mutation_p.C429R			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	429						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						CCATGAGGACTGCCACATCCC	0.517000													13	17					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141619474	141619474	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:141619474G>A	ENST00000548136.1	+	1	858	c.799G>A	c.(799-801)Gca>Aca	p.A267T	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					GCAAACGCAGGCAGCTGATTA	0.483000													20	29					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32015602	32015602	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32015602C>A	ENST00000375244.3	-	30	10434	c.10233G>T	c.(10231-10233)caG>caT	p.Q3411H	TNXB_ENST00000375247.2_Missense_Mutation_p.Q3409H			P22105	TENX_HUMAN	tenascin XB	3456	Fibronectin type-III 26.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCTCCAGGCCCTGGACTGTGA	0.602000													10	14					7.48243e-07	7.8103e-07	1	1	0
E4F1	1877	broad.mit.edu	37	16	2284279	2284279	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2284279G>A	ENST00000301727.4	+	10	1531	c.1483G>A	c.(1483-1485)Gac>Aac	p.D495N	E4F1_ENST00000564139.1_Missense_Mutation_p.D495N|E4F1_ENST00000565090.1_Intron	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	495	Interaction with BMI1.|Mediates interaction with CDKN2A.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						CCGCTGTGGCGACTGCGGGAA	0.657000													14	21					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43896378	43896378	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43896378G>A	ENST00000562955.1	+	31	4521	c.4521G>A	c.(4519-4521)ccG>ccA	p.P1507P	SZT2_ENST00000372442.1_Silent_p.P665P	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1564						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						ACCTGCCACCGCTCTTCCTGC	0.597000													47	90					0	0	1	0	0
ZNF506	440515	broad.mit.edu	37	19	19905509	19905509	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19905509G>A	ENST00000443905.2	-	4	1334	c.1187C>T	c.(1186-1188)cCg>cTg	p.P396L	ZNF506_ENST00000540806.2_Missense_Mutation_p.P396L|ZNF506_ENST00000450683.2_Missense_Mutation_p.P364L|CTC-559E9.6_ENST00000589657.1_RNA|CTC-559E9.4_ENST00000590274.1_lincRNA|CTC-559E9.6_ENST00000591884.1_RNA|ZNF506_ENST00000587461.1_Intron			Q5JVG8	ZN506_HUMAN	zinc finger protein 506	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(7)|lung(3)|skin(1)|stomach(1)	14						ACATTTGTACGGTTTCTCTCC	0.373000													29	44					0	0	1	0	0
GOT1L1	137362	broad.mit.edu	37	8	37794824	37794824	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:37794824C>T	ENST00000307599.4	-	4	589	c.490G>A	c.(490-492)Gac>Aac	p.D164N		NM_152413.2	NP_689626.2	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	164					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			central_nervous_system(1)|endometrium(3)|lung(8)|ovary(1)|prostate(1)	14	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			ATGTCGGGGTCCATGCATAGC	0.547000													4	11					0	0	1	0	0
ERCC1	2067	broad.mit.edu	37	19	45923631	45923631	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45923631C>T	ENST00000300853.3	-	4	967	c.376G>A	c.(376-378)Gta>Ata	p.V126I	ERCC1_ENST00000423698.2_Missense_Mutation_p.V54I|ERCC1_ENST00000591636.1_Missense_Mutation_p.V126I|ERCC1_ENST00000589165.1_Missense_Mutation_p.V126I|ERCC1_ENST00000340192.7_Missense_Mutation_p.V126I|ERCC1_ENST00000013807.5_Missense_Mutation_p.V126I	NM_001983.3	NP_001974.1	P07992	ERCC1_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	126					mitotic recombination|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to oxidative stress|transcription-coupled nucleotide-excision repair	cytoplasm|nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair complex	damaged DNA binding|endonuclease activity|protein C-terminus binding|protein domain specific binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|skin(1)	15		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0247)		TCGGGAATTACGTCGCCAAAT	0.607000								Nucleotide excision repair (NER)					13	25					0	0	1	0	0
MED26	9441	broad.mit.edu	37	19	16687166	16687166	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16687166C>T	ENST00000263390.3	-	3	1737	c.1475G>A	c.(1474-1476)cGg>cAg	p.R492Q	CTD-3222D19.2_ENST00000409035.1_Intron	NM_004831.3	NP_004822.2	O95402	MED26_HUMAN	mediator complex subunit 26	492					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	8						GCTGCTCTGCCGGCTCAGGTA	0.627000													15	26					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2120463	2120463	+	Missense_Mutation	SNP	C	C	A	rs137854119		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2120463C>A	ENST00000219476.3	+	17	2353	c.1723C>A	c.(1723-1725)Ctg>Atg	p.L575M	TSC2_ENST00000353929.4_Missense_Mutation_p.L575M|TSC2_ENST00000350773.4_Missense_Mutation_p.L575M|TSC2_ENST00000568454.1_Missense_Mutation_p.L586M|TSC2_ENST00000439673.2_Missense_Mutation_p.L538M|TSC2_ENST00000382538.6_Missense_Mutation_p.L526M|TSC2_ENST00000401874.2_Missense_Mutation_p.L575M	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	575					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				GCAGACCAAGCTGTACACCCT	0.622000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				12	22					5.50884e-06	5.70893e-06	1	1	0
KDM2B	84678	broad.mit.edu	37	12	121947469	121947469	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:121947469G>A	ENST00000377069.4	-	11	1861	c.1455C>T	c.(1453-1455)ggC>ggT	p.G485G	KDM2B_ENST00000542973.1_5'UTR|KDM2B_ENST00000538046.2_Silent_p.G426G|KDM2B_ENST00000536437.1_Silent_p.G399G|KDM2B_ENST00000377071.4_Silent_p.G516G	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	516					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						GAGCTTTCAGGCCCTTCAGTT	0.602000													14	18					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123812539	123812539	+	Translation_Start_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:123812539G>T	ENST00000223642.1	-	0	15					NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5						activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	GGAGGTAGCAGGAAACCACGG	0.373000													32	43					1.36615e-20	1.51493e-20	1	1	0
WDR62	284403	broad.mit.edu	37	19	36594432	36594432	+	Silent	SNP	C	C	T	rs143638774		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36594432C>T	ENST00000401500.2	+	30	3737	c.3702C>T	c.(3700-3702)ctC>ctT	p.L1234L	WDR62_ENST00000270301.7_Silent_p.L1229L	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	1229					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCATCTCCCTCGGTGACAGTG	0.667000													16	35					0	0	1	0	0
ZNF655	79027	broad.mit.edu	37	7	99171035	99171035	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99171035C>T	ENST00000424881.1	+	4	1629	c.1409C>T	c.(1408-1410)tCg>tTg	p.S470L	ZNF655_ENST00000394163.2_Missense_Mutation_p.S435L|ZNF655_ENST00000425063.1_3'UTR|ZNF655_ENST00000493277.1_Missense_Mutation_p.S470L|ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000252713.4_Missense_Mutation_p.S435L	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	435					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					AAAGAGAAATCGTATGAATGT	0.398000													25	42					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16264445	16264445	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16264445G>A	ENST00000375759.3	+	13	10852	c.10648G>A	c.(10648-10650)Gcc>Acc	p.A3550T		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3550	SPOC.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ACTAAGGATCGCCCAGAGGAT	0.622000													15	24					0	0	1	0	0
ZNF594	84622	broad.mit.edu	37	17	5085329	5085329	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:5085329G>T	ENST00000399604.4	-	1	2363	c.2223C>A	c.(2221-2223)acC>acA	p.T741T	ZNF594_ENST00000575779.1_Silent_p.T741T			Q96JF6	ZN594_HUMAN	zinc finger protein 594	741					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						CCTTGCTGAAGGTTTTCTCAC	0.443000													48	107					2.56175e-15	2.80342e-15	1	1	0
DTD1	92675	broad.mit.edu	37	20	18724893	18724893	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:18724893G>A	ENST00000377452.3	+	5	807	c.627G>A	c.(625-627)ccG>ccA	p.P209P		NM_080820.4	NP_543010.3	Q8TEA8	DTD1_HUMAN	D-tyrosyl-tRNA deacylase 1	209					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds			large_intestine(4)|lung(1)|ovary(2)	7						AACGGGAGCCGTAGCTCAGGA	0.547000													15	11					0	0	1	0	0
HDAC2	3066	broad.mit.edu	37	6	114267235	114267235	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:114267235G>T	ENST00000519065.1	-	9	1295	c.919C>A	c.(919-921)Cgt>Agt	p.R307S	HDAC2_ENST00000519108.1_Missense_Mutation_p.R277S|HDAC2_ENST00000368632.2_Missense_Mutation_p.R277S|HDAC2_ENST00000398283.2_Missense_Mutation_p.R401S			Q92769	HDAC2_HUMAN	histone deacetylase 2	307	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			biliary_tract(1)|central_nervous_system(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	GCAACATTACGGATTGTGTAG	0.378000													36	52					2.38352e-08	2.51487e-08	1	1	0
ZFPM2	23414	broad.mit.edu	37	8	106814712	106814712	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:106814712C>T	ENST00000407775.2	+	8	2652	c.2402C>T	c.(2401-2403)aCt>aTt	p.T801I	ZFPM2_ENST00000378472.4_Missense_Mutation_p.T532I|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.T669I|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.T669I|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	801					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CACTTGGAAACTTCTCTGACG	0.448000													7	18					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151836804	151836804	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:151836804G>A	ENST00000355193.2	-	57	14805	c.14587C>T	c.(14587-14589)Cga>Tga	p.R4863*	KMT2C_ENST00000262189.6_Nonsense_Mutation_p.R4806*|KMT2C_ENST00000485655.2_Nonsense_Mutation_p.R11*					lysine (K)-specific methyltransferase 2C																		ACTTCGTTTCGAATGATAGTC	0.463000													26	44					0	0	1	0	0
CORO2A	7464	broad.mit.edu	37	9	100897161	100897161	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:100897161G>A	ENST00000343933.5	-	4	652	c.395C>T	c.(394-396)gCg>gTg	p.A132V	CORO2A_ENST00000375077.4_Missense_Mutation_p.A132V	NM_003389.3	NP_003380.3	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	132					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|skin(4)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				TACTCTGCGCGCGTGGCCCAC	0.602000													7	7					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119031662	119031662	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:119031662G>A	ENST00000307417.3	+	15	2151	c.1787G>A	c.(1786-1788)cGc>cAc	p.R596H	ABCG4_ENST00000531739.1_Missense_Mutation_p.R596H|ABCG4_ENST00000449422.2_Missense_Mutation_p.R596H	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	596	ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity	p.R596H(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TTAGAGGAACGCTGCCCGTTC	0.557000													17	18					0	0	1	0	0
CSE1L	1434	broad.mit.edu	37	20	47706244	47706244	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:47706244C>T	ENST00000262982.2	+	19	2265	c.2142C>T	c.(2140-2142)cgC>cgT	p.R714R	CSE1L_ENST00000396192.3_Silent_p.R658R|CSE1L_ENST00000542325.1_Silent_p.R497R	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	714					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TCTTAGAACGCGGTTCAAACA	0.423000													12	48					0	0	1	0	0
ZNF839	55778	broad.mit.edu	37	14	102792778	102792778	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:102792778C>T	ENST00000262236.5	+	2	752	c.397C>T	c.(397-399)Cgt>Tgt	p.R133C	ZNF839_ENST00000442396.2_Missense_Mutation_p.R249C|ZNF839_ENST00000559185.1_Missense_Mutation_p.R133C|ZNF839_ENST00000558850.1_Missense_Mutation_p.R133C	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	133						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						AGTAAAGACACGTTCTGGACG	0.378000													20	12					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38527391	38527391	+	Missense_Mutation	SNP	C	C	T	rs61751711	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:38527391C>T	ENST00000263409.4	-	4	425	c.263G>A	c.(262-264)cGt>cAt	p.R88H	LIFR_ENST00000503088.1_5'UTR|LIFR_ENST00000453190.2_Missense_Mutation_p.R88H	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	88	Fibronectin type-III 1.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					ATAACAAGAACGGGACCTGTA	0.254000			T	PLAG1	salivary adenoma								22	33					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42929864	42929864	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42929864C>T	ENST00000426333.2	-	26	2925	c.2628G>A	c.(2626-2628)ccG>ccA	p.P876P	EFTUD2_ENST00000402521.3_Silent_p.P841P|EFTUD2_ENST00000591382.1_Silent_p.P876P|EFTUD2_ENST00000592576.1_Silent_p.P866P	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	876						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				AGTCGATGGCCGGGATAAAAG	0.532000													17	16					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63661997	63661997	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:63661997G>A	ENST00000279873.7	+	2	511	c.101G>A	c.(100-102)aGa>aAa	p.R34K		NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	34					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					GGCAAACCAAGAATTTTGTCC	0.502000													14	30					0	0	1	0	0
CHST3	9469	broad.mit.edu	37	10	73767213	73767213	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:73767213C>T	ENST00000373115.4	+	3	861	c.424C>T	c.(424-426)Cgc>Tgc	p.R142C		NM_004273.4	NP_004264.2	Q7LGC8	CHST3_HUMAN	carbohydrate (chondroitin 6) sulfotransferase 3	142					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity			endometrium(1)|lung(5)	6						GGCCACCACGCGCACCGGCTC	0.667000													6	6					0	0	1	0	0
EFCAB13	124989	broad.mit.edu	37	17	45421567	45421567	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:45421567A>G	ENST00000331493.2	+	7	754	c.343A>G	c.(343-345)Aca>Gca	p.T115A	ITGB3_ENST00000560629.1_3'UTR|ITGB3_ENST00000435993.2_3'UTR|EFCAB13_ENST00000517484.1_Missense_Mutation_p.T115A	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		GGAGAAGGTGACAAGGAAAGA	0.413000													34	44					0	0	1	0	0
CPNE3	8895	broad.mit.edu	37	8	87570575	87570575	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:87570575C>T	ENST00000521271.1	+	17	1713	c.1551C>T	c.(1549-1551)ggC>ggT	p.G517G	CPNE3_ENST00000198765.4_Silent_p.G517G	NM_003909.3	NP_003900.1	O75131	CPNE3_HUMAN	copine III	517					lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	23						AGGTGGTGGGCTACTTCAATA	0.433000													29	35					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151123859	151123859	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:151123859G>A	ENST00000370328.3	-	8	1171	c.1118C>T	c.(1117-1119)gCt>gTt	p.A373V	GABRE_ENST00000370325.1_Intron|GABRE_ENST00000483564.1_5'UTR	NM_004961.3	NP_004952.2	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	373					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TTTAGGAGAAGCATGGGCTTT	0.498000													20	6					0	0	1	0	0
HIST1H3G	8355	broad.mit.edu	37	6	26271587	26271587	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:26271587C>T	ENST00000305910.3	-	1	25	c.26G>A	c.(25-27)cGc>cAc	p.R9H		NM_003534.2	NP_003525.1	P68431	H31_HUMAN	histone cluster 1, H3g	9					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12						GGTGGACTTGCGTGCAGTCTG	0.572000													5	42					0	0	1	0	0
ACPP	55	broad.mit.edu	37	3	132050506	132050506	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:132050506C>T	ENST00000336375.5	+	3	322	c.232C>T	c.(232-234)Cat>Tat	p.H78Y	ACPP_ENST00000351273.7_Missense_Mutation_p.H78Y|ACPP_ENST00000489084.1_3'UTR|ACPP_ENST00000475741.1_Missense_Mutation_p.H78Y	NM_001099.4	NP_001090.2	P15309	PPAP_HUMAN	acid phosphatase, prostate	78						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						CATGGAGCAGCATTATGAACT	0.323000													18	44					0	0	1	0	0
SNRNP40	9410	broad.mit.edu	37	1	31744302	31744302	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:31744302G>A	ENST00000263694.4	-	6	717	c.699C>T	c.(697-699)ggC>ggT	p.G233G	SNRNP40_ENST00000489853.1_5'UTR|SNRNP40_ENST00000446633.2_Silent_p.G233G	NM_004814.2	NP_004805.2	Q96DI7	SNR40_HUMAN	small nuclear ribonucleoprotein 40kDa (U5)	233						catalytic step 2 spliceosome|cytoplasm|nucleoplasm|small nucleolar ribonucleoprotein complex|U5 snRNP	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	7						AATCTGCATGGCCTCTCATGG	0.438000													26	48					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26696054	26696054	+	Nonsense_Mutation	SNP	G	G	A	rs111033478		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:26696054G>A	ENST00000272371.2	-	29	3805	c.3679C>T	c.(3679-3681)Cga>Tga	p.R1227*	OTOF_ENST00000339598.3_Nonsense_Mutation_p.R480*|OTOF_ENST00000403946.3_Nonsense_Mutation_p.R1227*|OTOF_ENST00000338581.6_Nonsense_Mutation_p.R480*|OTOF_ENST00000402415.3_Nonsense_Mutation_p.R537*	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1227					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGAAGCGTCGCAGGGAGCTG	0.677000													13	16					0	0	1	0	0
S1PR2	9294	broad.mit.edu	37	19	10334659	10334659	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10334659G>A	ENST00000590320.1	-	2	1033	c.923C>T	c.(922-924)cCg>cTg	p.P308L		NM_004230.3	NP_004221.3	O95136	S1PR2_HUMAN	sphingosine-1-phosphate receptor 2	308					activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						CCCCACCCCCGGCCTCCAGCA	0.721000													6	7					0	0	1	0	0
DNHD1	144132	broad.mit.edu	37	11	6588935	6588935	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6588935C>T	ENST00000254579.6	+	36	12760	c.12196C>T	c.(12196-12198)Cgg>Tgg	p.R4066W	DNHD1_ENST00000527990.2_Missense_Mutation_p.R4066W	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	4066					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCTCCTGGGTCGGCCCCTGGA	0.602000													12	48					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147092700	147092700	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:147092700G>T	ENST00000361727.3	+	10	2014		c.e10-1			NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2						behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTGTTTCACAGGTTTTCTGAA	0.408000										HNSCC(39;0.1)			17	98					1.15088e-07	1.20771e-07	1	1	0
PCDHGA1	0	broad.mit.edu	37	5	140712458	140712458	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140712458C>T	ENST00000517417.1	+	1	2207	c.2207C>T	c.(2206-2208)cCc>cTc	p.P736L	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.P736L	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGCATGCCCGGTTCGCAC	0.637000													32	47					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104121053	104121053	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104121053C>T	ENST00000388887.2	+	47	5064	c.4860C>T	c.(4858-4860)ttC>ttT	p.F1620F		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1620	FAS1 5.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.F1620F(1)		NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGGAGCATTTCGTGAAAGATC	0.512000													17	183					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579467	7579467	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7579467C>T	ENST00000420246.2	-	4	352	c.220G>A	c.(220-222)Gcc>Acc	p.A74T	TP53_ENST00000359597.4_Missense_Mutation_p.A74T|TP53_ENST00000455263.2_Missense_Mutation_p.A74T|TP53_ENST00000445888.2_Missense_Mutation_p.A74T|TP53_ENST00000413465.2_Missense_Mutation_p.A74T|TP53_ENST00000269305.4_Missense_Mutation_p.A74T	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	74	Interaction with HRMT1L2.|Interaction with WWOX.		A -> T (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.G59fs*23(3)|p.V73fs*9(1)|p.R65fs*38(1)|p.E68fs*76(1)|p.D48fs*55(1)|p.A74fs*49(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)|p.A74fs*71(1)|p.A74fs*47(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTGCAGGGGCCACGGGGGGA	0.607000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			55	87					0	0	1	0	0
TBC1D25	4943	broad.mit.edu	37	X	48418543	48418543	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:48418543G>A	ENST00000376771.4	+	6	1588	c.1247G>A	c.(1246-1248)cGt>cAt	p.R416H	TBC1D25_ENST00000537536.1_Missense_Mutation_p.R162H|TBC1D25_ENST00000427713.1_3'UTR	NM_002536.2	NP_002527.1	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	416	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						GAACTCAAGCGTGAGTTCGCC	0.572000													12	1					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41267003	41267003	+	Missense_Mutation	SNP	G	G	A	rs144087793		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:41267003G>A	ENST00000349496.5	+	5	954	c.674G>A	c.(673-675)cGt>cAt	p.R225H	CTNNB1_ENST00000396185.3_Missense_Mutation_p.R225H|CTNNB1_ENST00000405570.1_Missense_Mutation_p.R225H|CTNNB1_ENST00000453024.1_Missense_Mutation_p.R218H|CTNNB1_ENST00000396183.3_Missense_Mutation_p.R225H	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	225					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TCCCATCATCGTGAGGGCTTA	0.453000		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				13	24					0	0	1	0	0
ARMCX5	64860	broad.mit.edu	37	X	101858624	101858624	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:101858624A>G	ENST00000604957.1	+	1	4177	c.1555A>G	c.(1555-1557)Aaa>Gaa	p.K519E	ARMCX5_ENST00000536530.1_Missense_Mutation_p.K519E|ARMCX5_ENST00000537008.1_Missense_Mutation_p.K519E|ARMCX5_ENST00000372742.1_Missense_Mutation_p.K519E|RP4-769N13.7_ENST00000602441.1_RNA|ARMCX5_ENST00000541409.1_Missense_Mutation_p.K519E|RP4-769N13.6_ENST00000476910.1_RNA|ARMCX5_ENST00000246174.2_Missense_Mutation_p.K519E	NM_001168478.1	NP_001161950.1	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	519							binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	22						AAAGTTCACTAAATCTGAGCT	0.333000													36	16					0	0	1	0	0
CTSK	1513	broad.mit.edu	37	1	150772104	150772104	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:150772104C>T	ENST00000271651.3	-	6	810	c.700G>A	c.(700-702)Gcc>Acc	p.A234T		NM_000396.3	NP_000387.1	P43235	CATK_HUMAN	cathepsin K	234					proteolysis	lysosome	cysteine-type endopeptidase activity|protein binding			cervix(1)|endometrium(1)|lung(4)|skin(1)	7	all_cancers(9;2.32e-51)|all_epithelial(9;3.89e-42)|all_lung(15;4.59e-35)|Lung NSC(24;1.7e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Colorectal(459;0.171)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTCTTCAGGGCTTTCTCATTC	0.512000													31	46					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18765459	18765459	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:18765459G>A	ENST00000304081.4	-	5	886	c.786C>T	c.(784-786)gaC>gaT	p.D262D	NT5C1B_ENST00000359846.2_Silent_p.D322D|NT5C1B-RDH14_ENST00000532967.1_Silent_p.D322D|NT5C1B_ENST00000600945.1_Silent_p.D322D	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TTTTCCTGCCGTCCACCATGT	0.557000													54	79					0	0	1	0	0
TTC30B	150737	broad.mit.edu	37	2	178416380	178416380	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:178416380G>A	ENST00000408939.2	-	1	1362	c.1112C>T	c.(1111-1113)gCt>gTt	p.A371V		NM_152517.2	NP_689730.2	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	371					cell projection organization	cilium	binding			cervix(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			CTCTTCAGGAGCTGTCTGGCA	0.473000													42	52					0	0	1	0	0
ZNF41	7592	broad.mit.edu	37	X	47307942	47307942	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:47307942T>C	ENST00000377065.4	-	5	1866	c.1227A>G	c.(1225-1227)aaA>aaG	p.K409K	ZNF41_ENST00000313116.7_Silent_p.K409K|ZNF41_ENST00000397050.2_Silent_p.K419K	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	451						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				ATTCATAGTGTTTCTCTCCGG	0.428000													71	7					0	0	1	0	0
CTSF	8722	broad.mit.edu	37	11	66333587	66333587	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66333587C>T	ENST00000310325.5	-	6	882	c.773G>A	c.(772-774)gGc>gAc	p.G258D		NM_003793.3	NP_003784.2	Q9UBX1	CATF_HUMAN	cathepsin F	258					proteolysis	lysosome	cysteine-type endopeptidase activity			endometrium(1)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CATCTTGTTGCCAGGCTCTTT	0.552000													14	25					0	0	1	0	0
SESN2	83667	broad.mit.edu	37	1	28595713	28595713	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:28595713C>T	ENST00000253063.3	+	2	431	c.110C>T	c.(109-111)gCt>gTt	p.A37V		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	37					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		GAGAGCCGGGCTCGGCGAGGC	0.557000													22	34					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31372436	31372436	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31372436C>T	ENST00000268296.4	+	9	1035	c.914C>T	c.(913-915)gCa>gTa	p.A305V	ITGAX_ENST00000562522.1_Missense_Mutation_p.A305V	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	305	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						AATGACATTGCATCGAAGCCC	0.368000													41	82					0	0	1	0	0
ZZZ3	26009	broad.mit.edu	37	1	78098877	78098877	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:78098877C>A	ENST00000370801.3	-	5	638	c.163G>T	c.(163-165)Gag>Tag	p.E55*	ZZZ3_ENST00000370798.1_Intron	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	55					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						GGCACAGGCTCTGGTCTCTTC	0.408000													62	101					2.17656e-39	2.44564e-39	1	1	0
HELB	92797	broad.mit.edu	37	12	66712428	66712428	+	Missense_Mutation	SNP	C	C	T	rs143522796	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:66712428C>T	ENST00000247815.4	+	7	2070	c.2011C>T	c.(2011-2013)Cgc>Tgc	p.R671C		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	671					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity	p.R671C(2)		autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		AATCTCAAGACGCCAATTTCC	0.313000													19	32					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3628712	3628712	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3628712T>C	ENST00000325418.4	+	1	1502	c.1483T>C	c.(1483-1485)Ttt>Ctt	p.F495L	ITGAE_ENST00000263087.4_Intron|ITGAE_ENST00000571185.1_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	495	Protein kinase.				cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										GGAAGGGGTGTTTGGCGAAGT	0.453000													33	46					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21402284	21402284	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:21402284C>T	ENST00000313654.9	+	20	2614	c.2373C>T	c.(2371-2373)taC>taT	p.Y791Y	LAMA3_ENST00000399516.3_Silent_p.Y791Y	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	791					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCTGAGATACGTTAACCCTG	0.383000													27	48					0	0	1	0	0
MFSD2B	388931	broad.mit.edu	37	2	24246538	24246538	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:24246538G>A	ENST00000338315.4	+	12	1255	c.1255G>A	c.(1255-1257)Gtc>Atc	p.V419I	MFSD2B_ENST00000406420.3_Missense_Mutation_p.V419I			A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing 2B	419					transport	integral to membrane				cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10						CTCCTCCTACGTCTTCTTCAC	0.607000													32	58					0	0	1	0	0
CCNI	10983	broad.mit.edu	37	4	77969538	77969538	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:77969538C>T	ENST00000237654.4	-	7	1544	c.968G>A	c.(967-969)cGc>cAc	p.R323H	CCNI_ENST00000537948.1_Missense_Mutation_p.R309H	NM_006835.2	NP_006826.1	Q14094	CCNI_HUMAN	cyclin I	323					spermatogenesis					NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9						CTCTACTTTGCGTTTAGTAGA	0.468000													29	53					0	0	1	0	0
MICAL1	64780	broad.mit.edu	37	6	109775015	109775015	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:109775015G>A	ENST00000368952.4	-	3	639	c.349C>T	c.(349-351)Cgg>Tgg	p.R117W	MICAL1_ENST00000358577.3_Missense_Mutation_p.R98W|MICAL1_ENST00000358807.3_Missense_Mutation_p.R98W			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	98					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		ACAGCGACCCGCAGCCCGCAA	0.652000													22	39					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168106837	168106837	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:168106837C>T	ENST00000409195.1	+	9	9024	c.8935C>T	c.(8935-8937)Cta>Tta	p.L2979L	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Silent_p.L2979L|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Silent_p.L2757L|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2804					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATTTCAGACACTATTAAATAC	0.348000													30	36					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50190921	50190921	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:50190921G>A	ENST00000335999.6	-	8	923	c.722C>T	c.(721-723)gCg>gTg	p.A241V		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	237	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CAGGCAGGGCGCCCAGGGTGA	0.731000													4	10					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189020257	189020257	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:189020257G>A	ENST00000512729.1	-	4	777	c.403C>T	c.(403-405)Cgc>Tgc	p.R135C	TRIML2_ENST00000326754.3_Missense_Mutation_p.R135C|TRIML2_ENST00000536972.1_Missense_Mutation_p.R185C	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	135							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		AGGAGGCTGCGGACCTGTTCA	0.483000													36	48					0	0	1	0	0
ZCWPW1	55063	broad.mit.edu	37	7	99999658	99999658	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99999658C>T	ENST00000398027.2	-	17	1725	c.1478G>A	c.(1477-1479)gGg>gAg	p.G493E	ZCWPW1_ENST00000490721.1_Intron|ZCWPW1_ENST00000360951.4_Intron|ZCWPW1_ENST00000324725.6_Intron	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	493							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGCATCACCCCCAAGCCCTAG	0.542000													4	110					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8997151	8997151	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8997151G>T	ENST00000397910.4	-	60	41248	c.41045C>A	c.(41044-41046)cCt>cAt	p.P13682H	MUC16_ENST00000380951.5_Missense_Mutation_p.P323H	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13684	SEA 11.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGAGTACAGAGGGCCAACACT	0.552000													29	49					1.36161e-19	1.50697e-19	1	1	0
MFN2	9927	broad.mit.edu	37	1	12049245	12049245	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12049245G>A	ENST00000235329.5	+	3	342	c.20G>A	c.(19-21)cGa>cAa	p.R7Q	MFN2_ENST00000444836.1_Missense_Mutation_p.R7Q|MFN2_ENST00000497302.1_3'UTR	NM_014874.3	NP_055689.1	O95140	MFN2_HUMAN	mitofusin 2	7					blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding	p.R7L(1)		endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	20	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CTCTTCTCTCGATGCAACTCT	0.493000													46	37					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35980127	35980127	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:35980127G>A	ENST00000490799.1	-	3	564	c.211C>T	c.(211-213)Cga>Tga	p.R71*	SLC26A8_ENST00000394602.2_Nonsense_Mutation_p.R71*|SLC26A8_ENST00000355574.2_Nonsense_Mutation_p.R71*	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	71					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						AGCACGCATCGTAGGAACCTG	0.468000													16	43					0	0	1	0	0
ZNF234	10780	broad.mit.edu	37	19	44661065	44661065	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44661065G>A	ENST00000426739.2	+	6	1154	c.896G>A	c.(895-897)cGt>cAt	p.R299H	ZNF234_ENST00000592437.1_Missense_Mutation_p.R299H	NM_006630.2	NP_006621.1	Q14588	ZN234_HUMAN	zinc finger protein 234	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)	23		Prostate(69;0.0435)				AACTTCCGTCGTAGATCAGCA	0.428000													35	68					0	0	1	0	0
LDB3	11155	broad.mit.edu	37	10	88441268	88441268	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:88441268C>A	ENST00000429277.2	+	5	542	c.397C>A	c.(397-399)Cca>Aca	p.P133T	LDB3_ENST00000352360.5_Intron|LDB3_ENST00000310944.6_Missense_Mutation_p.P133T|LDB3_ENST00000361373.4_Missense_Mutation_p.P133T|LDB3_ENST00000263066.6_Intron|LDB3_ENST00000458213.2_Intron|LDB3_ENST00000542786.1_Missense_Mutation_p.P133T|LDB3_ENST00000372056.4_Missense_Mutation_p.P133T|LDB3_ENST00000372066.3_Intron	NM_001171610.1	NP_001165081.1	O75112	LDB3_HUMAN	LIM domain binding 3	133						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|soft_tissue(1)	25						CCCAGGCACCCCAGGCACCCC	0.736000													13	35					0.00010058	0.000103117	1	1	0
IRF9	10379	broad.mit.edu	37	14	24633987	24633987	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24633987C>T	ENST00000396864.3	+	7	1101	c.814C>T	c.(814-816)Ctg>Ttg	p.L272L	IRF9_ENST00000557894.1_Silent_p.L170L|RP11-468E2.4_ENST00000558468.1_3'UTR	NM_006084.4	NP_006075.3	Q00978	IRF9_HUMAN	interferon regulatory factor 9	272					interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(265;0.00853)		GCAGCGCCTGCTGAGCCAGCT	0.662000													26	30					0	0	1	0	0
NMT1	4836	broad.mit.edu	37	17	43180471	43180471	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:43180471C>T	ENST00000592782.1	+	10	1277	c.1146C>T	c.(1144-1146)atC>atT	p.I382I	NMT1_ENST00000258960.2_Silent_p.I382I			P30419	NMT1_HUMAN	N-myristoyltransferase 1	382					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	8		Prostate(33;0.155)				AGAATATCATCGACACTTTCG	0.582000													11	35					0	0	1	0	0
ZNF77	58492	broad.mit.edu	37	19	2933820	2933820	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2933820G>T	ENST00000314531.4	-	4	1397	c.1305C>A	c.(1303-1305)ccC>ccA	p.P435P		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		TACACTCAAAGGGCTTCTCTC	0.507000													15	44					1.49906e-05	1.54943e-05	1	1	0
CLIP2	7461	broad.mit.edu	37	7	73795146	73795146	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:73795146C>T	ENST00000223398.6	+	11	2759	c.2432C>T	c.(2431-2433)tCg>tTg	p.S811L	CLIP2_ENST00000395060.1_Missense_Mutation_p.S811L|CLIP2_ENST00000361545.5_Missense_Mutation_p.S776L	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	811						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						ATGATTGAGTCGAATGACATT	0.607000													55	76					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	137013258	137013258	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137013258C>A	ENST00000508657.1	-	6	1230	c.516G>T	c.(514-516)aaG>aaT	p.K172N	KLHL3_ENST00000541417.1_Missense_Mutation_p.K84N|KLHL3_ENST00000394937.3_Missense_Mutation_p.K204N|KLHL3_ENST00000506491.1_Missense_Mutation_p.K122N|KLHL3_ENST00000309755.4_Missense_Mutation_p.K204N	NM_001257194.1	NP_001244123.1	Q9UH77	KLHL3_HUMAN	kelch-like family member 3	204						cytoplasm|cytoskeleton	actin binding|structural molecule activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		AAACGGTCAGCTTGTCGCTGG	0.493000													39	51					2.00842e-17	2.21064e-17	1	1	0
CCDC74B	91409	broad.mit.edu	37	2	130897505	130897505	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:130897505C>T	ENST00000392984.3	-	6	2015	c.1272G>A	c.(1270-1272)acG>acA	p.T424T	CCDC74B_ENST00000310463.6_Silent_p.T322T|CCDC74B_ENST00000409943.3_Silent_p.T256T			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	322										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					TGGGGAAATGCGTGGCTTCTT	0.632000													16	23					0	0	1	0	0
TRAK1	22906	broad.mit.edu	37	3	42264875	42264875	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:42264875G>A	ENST00000327628.5	+	16	2908	c.2508G>A	c.(2506-2508)gtG>gtA	p.V836V	TRAK1_ENST00000396175.1_Silent_p.V778V|TRAK1_ENST00000487159.1_3'UTR	NM_001042646.2	NP_001036111.1	Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	836					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						AGACCGACGTGTCCGTCTCCA	0.592000													4	15					0	0	1	0	0
ENTPD4	9583	broad.mit.edu	37	8	23297339	23297339	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:23297339C>T	ENST00000358689.4	-	9	1207	c.972G>A	c.(970-972)acG>acA	p.T324T	ENTPD4_ENST00000417069.2_Silent_p.T316T|ENTPD4_ENST00000356206.6_Silent_p.T316T	NM_001128930.2|NM_004901.4	NP_001122402.1|NP_004892.1	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	324					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		ACCCAAGAAACGTGGCCACAT	0.423000													26	35					0	0	1	0	0
LANCL1	10314	broad.mit.edu	37	2	211319934	211319934	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:211319934G>A	ENST00000443314.1	-	3	646	c.304C>T	c.(304-306)Cgc>Tgc	p.R102C	AC007970.1_ENST00000433296.1_RNA|AC007970.1_ENST00000420418.1_RNA|LANCL1_ENST00000431941.2_Missense_Mutation_p.R102C|LANCL1_ENST00000441020.3_Missense_Mutation_p.R102C|LANCL1_ENST00000233714.4_Missense_Mutation_p.R102C|LANCL1_ENST00000450366.2_Missense_Mutation_p.R102C			O43813	LANC1_HUMAN	LanC lantibiotic synthetase component C-like 1 (bacterial)	102						cytoplasm|integral to plasma membrane|microtubule cytoskeleton|nucleus	catalytic activity|G-protein coupled receptor activity|glutathione binding|low-density lipoprotein particle receptor binding|SH3 domain binding|zinc ion binding			breast(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12				Epithelial(149;0.00562)|Lung(261;0.0468)|LUSC - Lung squamous cell carcinoma(261;0.0495)|all cancers(144;0.0569)		GTGATGGAGCGCTTGGTTAAG	0.483000													28	39					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6985305	6985305	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:6985305G>A	ENST00000389658.3	-	39	5684	c.5591C>T	c.(5590-5592)gCa>gTa	p.A1864V		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1864	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGGTCGACTGCGTTCCTTTG	0.498000													27	139					0	0	1	0	0
GRAMD2	196996	broad.mit.edu	37	15	72454678	72454678	+	Missense_Mutation	SNP	G	G	A	rs144563180	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:72454678G>A	ENST00000309731.7	-	11	1010	c.997C>T	c.(997-999)Cgt>Tgt	p.R333C		NM_001012642.2	NP_001012660.1	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	333						integral to membrane				cervix(2)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	13						CGAGAAATACGGAACGCCAGG	0.478000													14	19					0	0	1	0	0
CREB1	1385	broad.mit.edu	37	2	208442363	208442363	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:208442363C>T	ENST00000432329.2	+	8	1116	c.865C>T	c.(865-867)Cgt>Tgt	p.R289C	CREB1_ENST00000430624.1_Missense_Mutation_p.R275C|CREB1_ENST00000374397.4_Missense_Mutation_p.R178C|CREB1_ENST00000353267.3_Missense_Mutation_p.R275C	NM_134442.3	NP_604391.1	P16220	CREB1_HUMAN	cAMP responsive element binding protein 1	289					activation of phospholipase C activity|axon guidance|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein dimerization activity|transcription cofactor activity		EWSR1/CREB1(44)	NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|upper_aerodigestive_tract(1)	5				LUSC - Lung squamous cell carcinoma(261;0.0768)|Epithelial(149;0.127)|Lung(261;0.145)	Adenosine monophosphate(DB00131)|Bromocriptine(DB01200)|Naloxone(DB01183)	GAGAGAGGTCCGTCTAATGAA	0.453000			T	EWSR1	"""clear cell sarcoma, angiomatoid fibrous histiocytoma"""								4	17					0	0	1	0	0
MCM3	4172	broad.mit.edu	37	6	52141945	52141945	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:52141945G>A	ENST00000596288.1	-	8	1247	c.1220C>T	c.(1219-1221)gCa>gTa	p.A407V	MCM3_ENST00000229854.7_Missense_Mutation_p.A362V|MCM3_ENST00000419835.2_Missense_Mutation_p.A316V|MCM3_ENST00000476448.1_5'UTR	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	362	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					AGCTCGGGGTGCAGTGCAAAG	0.602000													18	21					0	0	1	0	0
PPP2R5A	5525	broad.mit.edu	37	1	212520718	212520718	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:212520718G>A	ENST00000261461.2	+	6	1308	c.734G>A	c.(733-735)gGt>gAt	p.G245D	PPP2R5A_ENST00000537030.3_Missense_Mutation_p.G188D	NM_006243.3	NP_006234.1	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B', alpha	245					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)	16				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)		CATTTCAATGGTGTTGCTGAA	0.294000													7	21					0	0	1	0	0
ACP1	52	broad.mit.edu	37	2	272206	272206	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:272206C>T	ENST00000405233.1	+	4	200	c.161C>T	c.(160-162)gCg>gTg	p.A54V	ACP1_ENST00000439645.2_Silent_p.S44S|ACP1_ENST00000272067.6_Silent_p.S44S|ACP1_ENST00000484464.1_Intron|ACP1_ENST00000407983.3_Missense_Mutation_p.A96V|ACP1_ENST00000272065.5_Intron			P24666	PPAC_HUMAN	acid phosphatase 1, soluble	0						cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity	p.S44S(1)		endometrium(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)		TCATTGACAGCGGTGCTGTTT	0.542000													16	13					0	0	1	0	0
MYO1C	4641	broad.mit.edu	37	17	1386310	1386310	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1386310G>A	ENST00000359786.5	-	4	715	c.391C>T	c.(391-393)Cgt>Tgt	p.R131C	MYO1C_ENST00000545534.2_Missense_Mutation_p.R107C|MYO1C_ENST00000361007.2_Missense_Mutation_p.R96C|MYO1C_ENST00000438665.2_Missense_Mutation_p.R112C|MYO1C_ENST00000575158.1_Missense_Mutation_p.R96C	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	131	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TGGTCCCGACGCTCCGTGCGC	0.672000													7	9					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100373386	100373386	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100373386C>T	ENST00000542585.1	+	0	6268				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACATCAAGATCGGGGTGCAAG	0.493000													18	23					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6202613	6202613	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:6202613G>A	ENST00000262450.3	-	14	2195	c.2096C>T	c.(2095-2097)aCa>aTa	p.T699I	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	699					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CGGGTGCAGTGTGCCGCCTGT	0.642000													19	41					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40558599	40558599	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40558599G>T	ENST00000455577.2	+	5	1673	c.761G>T	c.(760-762)aGc>aTc	p.S254I	PAK6_ENST00000542403.2_Missense_Mutation_p.S254I|PAK6_ENST00000560346.1_Missense_Mutation_p.S254I|RP11-133K1.2_ENST00000558658.1_3'UTR|PAK6_ENST00000441369.1_Missense_Mutation_p.S254I|PAK6_ENST00000559901.1_3'UTR|PAK6_ENST00000260404.4_Missense_Mutation_p.S254I|PAK6_ENST00000453867.1_Missense_Mutation_p.S254I	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	254	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		ACCCGGGAGAGCAGCCTGAAG	0.647000													6	14					3.59834e-05	3.7043e-05	1	1	0
MTMR4	9110	broad.mit.edu	37	17	56582922	56582922	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56582922G>A	ENST00000323456.5	-	11	1138	c.1014C>T	c.(1012-1014)gtC>gtT	p.V338V	MTMR4_ENST00000579925.1_Silent_p.V338V	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	338	Myotubularin phosphatase.					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCATGAACACGACCTCACAGT	0.552000													21	50					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189526227	189526227	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:189526227C>T	ENST00000264731.3	+	4	580	c.491C>T	c.(490-492)gCc>gTc	p.A164V	TP63_ENST00000382063.4_Intron|TP63_ENST00000456148.1_Missense_Mutation_p.A70V|TP63_ENST00000392463.2_Missense_Mutation_p.A70V|TP63_ENST00000440651.2_Missense_Mutation_p.A164V|TP63_ENST00000418709.2_Missense_Mutation_p.A164V|TP63_ENST00000437221.1_Missense_Mutation_p.A70V|TP63_ENST00000392461.3_Missense_Mutation_p.A70V|TP63_ENST00000354600.5_Missense_Mutation_p.A70V|TP63_ENST00000449992.1_Intron|TP63_ENST00000320472.5_Missense_Mutation_p.A164V|TP63_ENST00000392460.3_Missense_Mutation_p.A164V	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	164					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CCATCACCCGCCATCCCCTCC	0.637000										HNSCC(45;0.13)			10	22					0	0	1	0	0
SFI1	9814	broad.mit.edu	37	22	32009508	32009508	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:32009508C>T	ENST00000432498.1	+	25	3034	c.2641C>T	c.(2641-2643)Cag>Tag	p.Q881*	SFI1_ENST00000443011.1_Nonsense_Mutation_p.Q759*|SFI1_ENST00000414585.1_Nonsense_Mutation_p.Q759*|SFI1_ENST00000400288.2_Nonsense_Mutation_p.Q912*|SFI1_ENST00000400289.1_Nonsense_Mutation_p.Q830*|SFI1_ENST00000540643.1_Nonsense_Mutation_p.Q857*|SFI1_ENST00000443326.1_Nonsense_Mutation_p.Q830*	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	912					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						GGCCCAGCAGCAGGTCCAGGT	0.677000													4	5					0	0	1	0	0
LSM3	27258	broad.mit.edu	37	3	14225447	14225447	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:14225447A>G	ENST00000306024.3	+	3	646	c.143A>G	c.(142-144)cAa>cGa	p.Q48R		NM_014463.2	NP_055278.1	P62310	LSM3_HUMAN	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	48					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	catalytic step 2 spliceosome|cytosol	protein binding|RNA binding			central_nervous_system(1)|large_intestine(2)|ovary(1)	4						GCTTATGATCAACATTTAAAT	0.294000													10	67					0	0	1	0	0
ZNF219	0	broad.mit.edu	37	14	21561142	21561142	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:21561142C>T	ENST00000360947.3	-	3	725	c.314G>A	c.(313-315)cGc>cAc	p.R105H	ZNF219_ENST00000451119.2_Missense_Mutation_p.R105H|ZNF219_ENST00000421093.2_Missense_Mutation_p.R105H	NM_016423.2	NP_057507.2	Q9P2Y4	ZN219_HUMAN	zinc finger protein 219	105					negative regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|histamine receptor activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(2)	8	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;9.86e-11)|Epithelial(56;1.27e-08)|all cancers(55;6.06e-08)	GBM - Glioblastoma multiforme(265;0.0191)		CTGGTGTGTGCGCAGGTGCGA	0.711000											OREG0022565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	13					0	0	1	0	0
OR5J2	282775	broad.mit.edu	37	11	55944981	55944981	+	Silent	SNP	C	C	T	rs142214796	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55944981C>T	ENST00000312298.1	+	1	888	c.888C>T	c.(886-888)gaC>gaT	p.D296D		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D296D(2)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					GAAACAAGGACGTAAAGGAGG	0.383000													5	15					0	0	1	0	0
C19orf40	91442	broad.mit.edu	37	19	33464132	33464132	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:33464132C>A	ENST00000588258.1	+	2	140	c.30C>A	c.(28-30)ggC>ggA	p.G10G	C19orf40_ENST00000589646.1_Intron|C19orf40_ENST00000590281.1_Silent_p.G10G|C19orf40_ENST00000590179.1_Intron	NM_152266.3	NP_689479.1	Q9BTP7	FAP24_HUMAN	chromosome 19 open reading frame 40	10					DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Esophageal squamous(110;0.137)					ATGATACGGGCCCCGTGCACG	0.617000								Direct reversal of damage					20	29					2.37509e-13	2.57931e-13	1	1	0
ZNF454	285676	broad.mit.edu	37	5	178392866	178392866	+	Silent	SNP	G	G	A	rs13187000	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:178392866G>A	ENST00000320129.3	+	5	1764	c.1461G>A	c.(1459-1461)caG>caA	p.Q487Q	ZNF454_ENST00000519564.1_Silent_p.Q487Q	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	487					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		CTCAACATCAGAGGATTCACA	0.393000													31	38					0	0	1	0	0
BHLHB9	80823	broad.mit.edu	37	X	102004720	102004720	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:102004720G>A	ENST00000372735.1	+	4	1382	c.797G>A	c.(796-798)cGc>cAc	p.R266H	BHLHB9_ENST00000457056.1_Missense_Mutation_p.R266H|BHLHB9_ENST00000361229.4_Missense_Mutation_p.R266H|BHLHB9_ENST00000447531.1_Missense_Mutation_p.R266H|BHLHB9_ENST00000448867.1_Missense_Mutation_p.R266H			Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class B, 9	266						cytoplasm|nucleus	binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						ACAGCTTGCCGCCCTTCTAGG	0.502000													7	53					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20167421	20167421	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:20167421G>A	ENST00000263754.4	+	10	1893	c.1438G>A	c.(1438-1440)Gcc>Acc	p.A480T		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	480					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						AGCACACTCGGCCAGGGATGA	0.478000													20	35					0	0	1	0	0
PRL	5617	broad.mit.edu	37	6	22290546	22290546	+	Nonsense_Mutation	SNP	G	G	A	rs6238		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:22290546G>A	ENST00000306482.1	-	4	867	c.349C>T	c.(349-351)Cga>Tga	p.R117*	RP3-404K8.2_ENST00000561912.1_RNA	NM_000948.5|NM_001163558.2	NP_000939.1|NP_001157030.1	P01236	PRL_HUMAN	prolactin	117					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding	p.R117*(1)		NS(1)|endometrium(2)|large_intestine(6)|lung(6)|prostate(1)	16	Ovarian(93;0.163)					TTCCAGGATCGCAATATGCTG	0.428000													27	39					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55892669	55892669	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:55892669G>A	ENST00000373965.2	-	16	2298	c.1904C>T	c.(1903-1905)gCc>gTc	p.A635V	PCDH15_ENST00000373957.3_Missense_Mutation_p.A606V|PCDH15_ENST00000320301.6_Missense_Mutation_p.A628V|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000409834.1_Missense_Mutation_p.A239V|PCDH15_ENST00000361849.3_Missense_Mutation_p.A628V|PCDH15_ENST00000437009.1_Intron|PCDH15_ENST00000373955.1_Missense_Mutation_p.A628V|PCDH15_ENST00000414778.1_Missense_Mutation_p.A633V|PCDH15_ENST00000395433.1_Missense_Mutation_p.A606V|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.A628V|PCDH15_ENST00000395445.1_Missense_Mutation_p.A635V|PCDH15_ENST00000395446.1_Missense_Mutation_p.A628V|PCDH15_ENST00000395438.1_Missense_Mutation_p.A628V|PCDH15_ENST00000395432.2_Missense_Mutation_p.A591V	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	628	Cadherin 6.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AACCCTCATGGCTTCACTAAT	0.413000										HNSCC(58;0.16)			9	16					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56400901	56400901	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56400901C>T	ENST00000355701.3	-	6	1818	c.948G>A	c.(946-948)acG>acA	p.T316T	BZRAP1_ENST00000268893.6_Silent_p.T256T|BZRAP1_ENST00000343736.4_Silent_p.T316T	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	316						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCTCCTGGGGCGTGGCCTGGA	0.657000													30	42					0	0	1	0	0
IL17RD	54756	broad.mit.edu	37	3	57131981	57131981	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:57131981A>G	ENST00000296318.7	-	12	1838	c.1750T>C	c.(1750-1752)Tcg>Ccg	p.S584P	IL17RD_ENST00000320057.5_Missense_Mutation_p.S440P|IL17RD_ENST00000463523.1_Missense_Mutation_p.S440P|IL17RD_ENST00000427856.2_Missense_Mutation_p.S560P	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	584						Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		ACCAAGCCCGAATCAAATTTC	0.537000													10	19					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68597347	68597347	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:68597347C>A	ENST00000570495.1	+	5	949	c.657C>A	c.(655-657)gcC>gcA	p.A219A	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000563169.2_Silent_p.A219A|ZFP90_ENST00000398253.2_Silent_p.A219A			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	219					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		GTAGAAAAGCCTTTATTCATA	0.348000													19	71					5.03518e-11	5.40566e-11	1	1	0
GOSR1	9527	broad.mit.edu	37	17	28849325	28849325	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:28849325C>T	ENST00000225724.5	+	9	754	c.682C>T	c.(682-684)Cgg>Tgg	p.R228W	GOSR1_ENST00000581721.1_Missense_Mutation_p.R214W|GOSR1_ENST00000451249.2_Missense_Mutation_p.R226W|GOSR1_ENST00000467337.2_Missense_Mutation_p.R163W	NM_001007024.1|NM_001007025.1|NM_004871.2	NP_001007025.1|NP_001007026.1|NP_004862.1	O95249	GOSR1_HUMAN	golgi SNAP receptor complex member 1	228					intra-Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|SNARE complex	SNAP receptor activity			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)	12						GAGGAAGCGGCGGGACTCGCT	0.493000													96	143					0	0	1	0	0
PPAN	56342	broad.mit.edu	37	19	10225092	10225092	+	Missense_Mutation	SNP	G	G	A	rs139449846		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10225092G>A	ENST00000556468.1	+	13	2090	c.2063G>A	c.(2062-2064)cGg>cAg	p.R688Q	P2RY11_ENST00000321826.4_Missense_Mutation_p.R268Q|PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.R688Q|PPAN-P2RY11_ENST00000428358.1_3'UTR					peter pan homolog (Drosophila)											endometrium(3)|liver(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			CACATCATGCGGGTGCTCAAC	0.662000													12	65					0	0	1	0	0
SLC25A31	83447	broad.mit.edu	37	4	128688340	128688340	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:128688340C>T	ENST00000281154.4	+	4	766	c.598C>T	c.(598-600)Cga>Tga	p.R200*		NM_031291.2	NP_112581.1	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31	200					transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity			NS(1)|breast(1)|large_intestine(10)|lung(8)|skin(2)	22						CATTGTGTACCGAGCCTCTTA	0.358000													7	141					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17052134	17052134	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:17052134G>A	ENST00000418129.2	+	2	1383	c.918G>A	c.(916-918)ctG>ctA	p.L306L	PLCL2_ENST00000460467.1_Intron|PLCL2_ENST00000432376.1_Silent_p.L306L|PLCL2_ENST00000396755.2_Silent_p.L306L	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	432					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						AGCAACCTCTGTCTCATTACT	0.398000													43	49					0	0	1	0	0
FOXO1	2308	broad.mit.edu	37	13	41134687	41134687	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:41134687C>T	ENST00000379561.5	-	2	1325	c.941G>A	c.(940-942)cGc>cAc	p.R314H		NM_002015.3	NP_002006.2	Q12778	FOXO1_HUMAN	forkhead box O1	314					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX7/FOXO1(197)|PAX3/FOXO1(749)	central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	20		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		AGTTCGAGGGCGAAATGTACT	0.498000													29	31					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43484781	43484781	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:43484781C>T	ENST00000395891.1	+	11	2615	c.2010C>T	c.(2008-2010)tgC>tgT	p.C670C	HECW1_ENST00000453890.1_Silent_p.C670C	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	670	Cys-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						ACCACAGTTGCGAGGGCTGTG	0.682000													7	10					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5283038	5283038	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:5283038C>T	ENST00000546004.1	-	3	1049	c.803G>A	c.(802-804)cGc>cAc	p.R268H	PROKR2_ENST00000217270.3_Missense_Mutation_p.R268H			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	268			R -> C.			integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						CCTGCGGCAGCGCAGCCGCTT	0.597000										HNSCC(71;0.22)			8	27					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175979	57175979	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:57175979G>A	ENST00000537055.2	-	2	819	c.588C>T	c.(586-588)tgC>tgT	p.C196C		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						CGCAGTCGGCGCAGCGGTGCG	0.726000													11	8					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	74019646	74019646	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:74019646C>T	ENST00000358602.4	-	6	1301	c.1185G>A	c.(1183-1185)acG>acA	p.T395T	ANKRD17_ENST00000330838.6_Silent_p.T395T|ANKRD17_ENST00000514252.1_5'UTR|ANKRD17_ENST00000509867.2_Silent_p.T282T	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	395					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CATTAGAATGCGTATTAATGC	0.363000													44	50					0	0	1	0	0
GPR63	0	broad.mit.edu	37	6	97246676	97246676	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:97246676C>T	ENST00000229955.3	-	2	1277	c.932G>A	c.(931-933)cGt>cAt	p.R311H	GPR63_ENST00000417980.1_Missense_Mutation_p.R311H	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	311						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		GGTGAAGGCACGTGTTTTAAA	0.478000													14	24					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186143767	186143767	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:186143767C>A	ENST00000271588.4	+	103	16165	c.15936C>A	c.(15934-15936)ccC>ccA	p.P5312P	HMCN1_ENST00000367492.2_Silent_p.P5312P	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	5312					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TTGGAAGACCCTGCATGGGTA	0.443000													18	18					2.37509e-13	2.57931e-13	1	1	0
PCDHA4	0	broad.mit.edu	37	5	140188302	140188302	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140188302G>A	ENST00000530339.1	+	1	1530	c.1530G>A	c.(1528-1530)gtG>gtA	p.V510V	PCDHA4_ENST00000512229.2_Silent_p.V510V|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000356878.4_Silent_p.V510V|PCDHA2_ENST00000526136.1_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGTTTCGGTGCATGCGGAGA	0.677000													21	20					0	0	1	0	0
ZFAT	57623	broad.mit.edu	37	8	135521921	135521921	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:135521921C>T	ENST00000520727.1	-	16	3696	c.3397G>A	c.(3397-3399)Gcc>Acc	p.A1133T	ZFAT_ENST00000520356.1_Intron|ZFAT_ENST00000429442.2_Intron|ZFAT_ENST00000520214.1_Missense_Mutation_p.A1133T|ZFAT_ENST00000523399.1_Missense_Mutation_p.A1083T|ZFAT_ENST00000377838.3_Missense_Mutation_p.A1145T	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	1145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			AGGGCAGTGGCGTCATGGGTC	0.577000													16	31					0	0	1	0	0
RAP1GDS1	5910	broad.mit.edu	37	4	99342450	99342450	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:99342450C>T	ENST00000408927.3	+	12	1458	c.1345C>T	c.(1345-1347)Cgt>Tgt	p.R449C	RAP1GDS1_ENST00000408900.3_Missense_Mutation_p.R400C|RAP1GDS1_ENST00000264572.7_Missense_Mutation_p.R358C|RAP1GDS1_ENST00000380158.4_Missense_Mutation_p.R401C|RAP1GDS1_ENST00000339360.5_Missense_Mutation_p.R450C|RAP1GDS1_ENST00000453712.2_Missense_Mutation_p.R449C	NM_001100426.1|NM_001100427.1|NM_021159.4	NP_001093896.1|NP_001093897.1|NP_066982.3	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1	449							binding|GTPase activator activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)	28				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		GTTAGTGGAGCGTTTGGTGGA	0.423000			T	NUP98	T-ALL								17	30					0	0	1	0	0
AOC4P	0	broad.mit.edu	37	17	41019975	41019975	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41019975G>A	ENST00000585538.1	+	0	814					NR_002773.1																						ACCTAGTTTGGCCTCTACTAC	0.607000													18	28					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105185201	105185201	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:105185201G>A	ENST00000369797.3	+	20	3318	c.3224G>A	c.(3223-3225)gGc>gAc	p.G1075D		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	1075	S1 motif 9.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GTTCCAGAGGGCACCTCTCCT	0.517000													28	30					0	0	1	0	0
SCP2	6342	broad.mit.edu	37	1	53516312	53516312	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:53516312G>A	ENST00000371514.3	+	16	1748	c.1580G>A	c.(1579-1581)gGc>gAc	p.G527D	SCP2_ENST00000371509.4_Missense_Mutation_p.G483D|SCP2_ENST00000528311.1_Missense_Mutation_p.G446D|SCP2_ENST00000407246.2_Missense_Mutation_p.G503D|SCP2_ENST00000488965.1_3'UTR|SCP2_ENST00000408941.3_3'UTR|SCP2_ENST00000435345.2_Missense_Mutation_p.G123D|SCP2_ENST00000430330.2_Missense_Mutation_p.G120D	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2	527	SCP2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						AAAATCACTGGCAACATGGGT	0.378000													16	62					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102522033	102522033	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:102522033C>T	ENST00000321521.9	+	27	3755	c.3182C>T	c.(3181-3183)gCg>gTg	p.A1061V	PPIP5K2_ENST00000414217.1_Missense_Mutation_p.A1061V|PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000358359.3_Missense_Mutation_p.A1061V			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	1061					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TCTCACTGTGCGGGCCTGTTT	0.488000													15	13					0	0	1	0	0
MARCH4	57574	broad.mit.edu	37	2	217124369	217124369	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:217124369C>T	ENST00000273067.4	-	4	2665	c.899G>A	c.(898-900)cGc>cAc	p.R300H	AC012513.6_ENST00000417481.1_RNA	NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	300						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		TTTAAAGATGCGGTACACCGA	0.542000													8	10					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910581	230910581	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:230910581A>G	ENST00000295190.4	-	4	1719	c.1261T>C	c.(1261-1263)Tat>Cat	p.Y421H		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	421						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		AGGGAGAAATAACCACTGGAA	0.502000													16	21					0	0	1	0	0
KIF23	9493	broad.mit.edu	37	15	69728547	69728547	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:69728547G>A	ENST00000260363.4	+	13	1460	c.1343G>A	c.(1342-1344)gGt>gAt	p.G448D	KIF23_ENST00000558585.1_Missense_Mutation_p.G265D|KIF23_ENST00000559279.1_Missense_Mutation_p.G448D|KIF23_ENST00000352331.4_Missense_Mutation_p.G448D|KIF23_ENST00000537891.1_Missense_Mutation_p.G265D|KIF23_ENST00000395392.2_Missense_Mutation_p.G448D	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	448					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						GCAATATGTGGTTTAACGCCT	0.413000													34	46					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256156	15256156	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:15256156G>A	ENST00000378116.4	-	8	1437	c.1431C>T	c.(1429-1431)taC>taT	p.Y477Y		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	477						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CCGAGGACTCGTAGCCTTCTC	0.483000													19	92					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9836542	9836542	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:9836542G>A	ENST00000506583.1	-	13	1512	c.1295C>T	c.(1294-1296)tCc>tTc	p.S432F	SLC2A9_ENST00000264784.3_Missense_Mutation_p.S461F|SLC2A9_ENST00000309065.3_Missense_Mutation_p.S432F			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	461					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						AGCAAAGTTGGAGAGCCAGTT	0.537000													11	11					0	0	1	0	0
WDR16	146845	broad.mit.edu	37	17	9489197	9489197	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:9489197C>T	ENST00000352665.5	+	2	247	c.178C>T	c.(178-180)Cta>Tta	p.L60L	WDR16_ENST00000299764.5_Silent_p.L70L|WDR16_ENST00000396219.3_Intron	NM_145054.4	NP_659491.4	Q8N1V2	WDR16_HUMAN	WD repeat domain 16	60						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31						GCAGAACTTCCTACAGGGTCA	0.493000													42	69					0	0	1	0	0
STIM2	57620	broad.mit.edu	37	4	27019579	27019579	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:27019579C>T	ENST00000382009.3	+	12	2288	c.2021C>T	c.(2020-2022)gCc>gTc	p.A674V	STIM2_ENST00000465503.1_Missense_Mutation_p.A587V|STIM2_ENST00000237364.5_Missense_Mutation_p.A666V|STIM2_ENST00000467011.1_Missense_Mutation_p.A579V|STIM2_ENST00000467087.1_Missense_Mutation_p.A579V|STIM2_ENST00000412829.2_Missense_Mutation_p.A666V	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	579					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				GAGGAAGAGGCCATTTACTTC	0.532000													97	147					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66873752	66873752	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:66873752C>T	ENST00000269080.2	-	31	4124	c.3987G>A	c.(3985-3987)gcG>gcA	p.A1329A	ABCA8_ENST00000430352.2_Silent_p.A1369A|ABCA8_ENST00000586539.1_Silent_p.A1369A	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1329	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					TGGGCCACAGCGCGTTCTCCT	0.602000													24	70					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70338440	70338440	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:70338440G>A	ENST00000338508.4	-	29	2441	c.2442_splice	c.e29+1	p.N814_splice	SHANK2_ENST00000449116.2_Splice_Site_p.N215_splice|SHANK2_ENST00000423696.2_Splice_Site_p.N434_splice|SHANK2_ENST00000449833.2_Splice_Site_p.N218_splice|SHANK2_ENST00000409530.1_Splice_Site_p.N224_splice|SHANK2_ENST00000357171.3_Splice_Site_p.N225_splice|SHANK2_ENST00000409161.1_Splice_Site_p.N217_splice			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	434					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGCCACTCACGTTCATGTCTG	0.662000													10	14					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104751018	104751018	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:104751018C>T	ENST00000311117.3	+	25	4484	c.3939C>T	c.(3937-3939)ggC>ggT	p.G1313G	KMT2E_ENST00000334914.7_Silent_p.G368G|KMT2E_ENST00000334877.4_Intron|KMT2E_ENST00000257745.4_Silent_p.G1313G	NM_182931.2	NP_891847.1			lysine (K)-specific methyltransferase 2E																		AAGCTAAGGGCCCAGTCCCTT	0.413000													34	46					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133331649	133331649	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:133331649G>A	ENST00000539605.1	-	1	6750	c.66C>T	c.(64-66)atC>atT	p.I22I	ANKLE2_ENST00000337516.5_Silent_p.I84I|ANKLE2_ENST00000357997.5_Silent_p.I84I			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	84						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		CGGCTTTGACGATTTCTTCTC	0.418000													40	65					0	0	1	0	0
ZEB2	9839	broad.mit.edu	37	2	145274891	145274891	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:145274891G>A	ENST00000558170.2	-	2	1211	c.27C>T	c.(25-27)ggC>ggT	p.G9G	ZEB2_ENST00000409487.3_Silent_p.G9G|ZEB2_ENST00000303660.4_Silent_p.G9G|ZEB2_ENST00000462355.1_Silent_p.G9G|ZEB2_ENST00000493689.1_5'UTR|ZEB2_ENST00000470879.1_Silent_p.G9G|ZEB2_ENST00000465070.1_Silent_p.G9G|ZEB2_ENST00000539609.3_Silent_p.G9G	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	9						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TGCACCGGGGGCCATCCGCCA	0.597000													32	67					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98519495	98519495	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:98519495C>T	ENST00000359863.4	+	21	2951	c.2742C>T	c.(2740-2742)taC>taT	p.Y914Y	TRRAP_ENST00000355540.3_Silent_p.Y914Y|TRRAP_ENST00000446306.3_Silent_p.Y913Y	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	914					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGCTGCACTACGTTGTGACCG	0.557000													26	48					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37692101	37692101	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37692101G>A	ENST00000248901.6	+	4	416	c.229G>A	c.(229-231)Gcc>Acc	p.A77T	CYTH4_ENST00000402997.1_Missense_Mutation_p.A77T|CYTH4_ENST00000405206.3_Missense_Mutation_p.A77T|CYTH4_ENST00000439667.1_3'UTR	NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	77	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						CATGGACCCCGCCAAGGTAGG	0.657000													5	17					0	0	1	0	0
PCDHA11	0	broad.mit.edu	37	5	140250190	140250190	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140250190G>A	ENST00000398640.2	+	1	1502	c.1502G>A	c.(1501-1503)cGc>cAc	p.R501H	PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGGGCGACCGCGCGCTGTCG	0.682000													27	58					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126336670	126336670	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126336670C>T	ENST00000394329.3	+	5	6565	c.6552C>T	c.(6550-6552)ggC>ggT	p.G2184G	FAT4_ENST00000335110.5_Silent_p.G482G	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2184	Cadherin 21.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAGATGAAGGCACAAATGGAC	0.418000													6	95					0	0	1	0	0
LEFTY1	10637	broad.mit.edu	37	1	226075694	226075694	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:226075694G>A	ENST00000272134.5	-	2	368	c.289C>T	c.(289-291)Cac>Tac	p.H97Y	RP4-559A3.7_ENST00000432920.2_Missense_Mutation_p.T205I|LEFTY1_ENST00000492457.1_5'UTR	NM_020997.3	NP_066277.1	O75610	LFTY1_HUMAN	left-right determination factor 1	97					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	10	Breast(184;0.197)					ACCAGCAGGTGTGTGCTGGCC	0.697000													5	9					0	0	1	0	0
ENPP7	339221	broad.mit.edu	37	17	77709121	77709121	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:77709121C>T	ENST00000328313.5	+	3	900	c.679C>T	c.(679-681)Cgg>Tgg	p.R227W		NM_178543.3	NP_848638.2	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 7	227					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity	p.R227W(1)		breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(6)|skin(3)	34			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGGCTACCTCCGGGAGAGCAT	0.672000													13	20					0	0	1	0	0
ZNF501	115560	broad.mit.edu	37	3	44776220	44776220	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:44776220G>A	ENST00000396048.2	+	3	744	c.307G>A	c.(307-309)Gag>Aag	p.E103K		NM_001258280.1|NM_145044.3	NP_001245209.1|NP_659481.2	Q96CX3	ZN501_HUMAN	zinc finger protein 501	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		TCATACTGGAGAGAAACCCTA	0.368000													5	101					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62730088	62730088	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:62730088G>A	ENST00000349451.3	+	6	1461	c.1049G>A	c.(1048-1050)cGc>cAc	p.R350H	OPRL1_ENST00000336866.2_Missense_Mutation_p.R350H|OPRL1_ENST00000355631.4_Missense_Mutation_p.R350H	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	350					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GACCGCGTGCGCAGCATTGCC	0.642000													10	23					0	0	1	0	0
MKL1	57591	broad.mit.edu	37	22	40820291	40820291	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:40820291C>T	ENST00000396617.3	-	8	986	c.396G>A	c.(394-396)gaG>gaA	p.E132E	MKL1_ENST00000407029.1_Silent_p.E132E|MKL1_ENST00000355630.3_Silent_p.E132E|MKL1_ENST00000402042.1_Silent_p.E132E			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	132	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						AACCCTGGGACTCATGGCTGG	0.602000			T	RBM15	acute megakaryocytic leukemia								23	77					0	0	1	0	0
ZNF3	7551	broad.mit.edu	37	7	99668884	99668884	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99668884C>T	ENST00000303915.6	-	5	2190	c.1223G>A	c.(1222-1224)aGc>aAc	p.S408N	ZNF3_ENST00000424697.1_Missense_Mutation_p.S408N|ZNF3_ENST00000299667.4_Missense_Mutation_p.S408N|ZNF3_ENST00000413658.2_Intron			P17036	ZNF3_HUMAN	zinc finger protein 3	408					cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	25	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			AAGAGCCGAGCTGTACCTGAA	0.483000													10	67					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1462106	1462106	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1462106G>A	ENST00000535453.1	+	13	3496	c.1783G>A	c.(1783-1785)Gcc>Acc	p.A595T	CTB-25B13.12_ENST00000588225.1_RNA|APC2_ENST00000233607.2_Missense_Mutation_p.A595T|C19orf25_ENST00000588427.1_Intron|APC2_ENST00000238483.4_Missense_Mutation_p.A321T			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	595					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAACTCGCTGGCCATCATCGA	0.657000													22	24					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55705966	55705966	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:55705966G>A	ENST00000379906.2	+	3	778	c.523G>A	c.(523-525)Gac>Aac	p.D175N	SLC6A2_ENST00000568943.1_Missense_Mutation_p.D175N|SLC6A2_ENST00000566163.1_Missense_Mutation_p.D175N|SLC6A2_ENST00000567238.1_Missense_Mutation_p.D70N|SLC6A2_ENST00000219833.8_Missense_Mutation_p.D175N|SLC6A2_ENST00000414754.3_Missense_Mutation_p.D175N|SLC6A2_ENST00000561820.1_Missense_Mutation_p.D175N	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	175					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GCCCTGGACCGACTGTGGCCA	0.557000													16	22					0	0	1	0	0
CPSF1	29894	broad.mit.edu	37	8	145626898	145626898	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145626898C>T	ENST00000349769.3	-	4	326	c.232G>A	c.(232-234)Gtc>Atc	p.V78I		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	78					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			ATGGACATGACGTTGCCAAAG	0.627000													6	11					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52540756	52540756	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52540756G>A	ENST00000321725.6	+	18	1955	c.1879G>A	c.(1879-1881)Gtg>Atg	p.V627M		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	627	FAS1 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GAGGGTAGACGTGATGGCCGC	0.682000													6	11					0	0	1	0	0
SLC16A6	9120	broad.mit.edu	37	17	66267677	66267677	+	Silent	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:66267677T>G	ENST00000327268.4	-	6	788	c.624A>C	c.(622-624)ccA>ccC	p.P208P	SLC16A6_ENST00000580666.1_Silent_p.P208P|ARSG_ENST00000448504.2_Intron	NM_001174166.1	NP_001167637.1	O15403	MOT7_HUMAN	solute carrier family 16, member 6	208						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			large_intestine(3)|lung(8)|prostate(1)|skin(1)|urinary_tract(2)	15	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	TCGGTGACGCTGGTCCTCTGA	0.468000													30	62					0	0	1	0	0
HARBI1	283254	broad.mit.edu	37	11	46637658	46637658	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46637658G>A	ENST00000326737.3	-	2	377	c.130C>T	c.(130-132)Cag>Tag	p.Q44*		NM_173811.3	NP_776172.1	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	44						cytoplasm|nucleus	metal ion binding|nuclease activity			large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)	3						TAAATGAACTGCCGTGGAAAC	0.493000													23	30					0	0	1	0	0
ENTPD3	956	broad.mit.edu	37	3	40453444	40453444	+	Missense_Mutation	SNP	G	G	A	rs145124056		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:40453444G>A	ENST00000301825.3	+	5	546	c.428G>A	c.(427-429)cGc>cAc	p.R143H	ENTPD3_ENST00000445129.1_Missense_Mutation_p.R143H|ENTPD3_ENST00000456402.1_Missense_Mutation_p.R143H|ENTPD3-AS1_ENST00000439293.1_RNA|ENTPD3-AS1_ENST00000452768.1_RNA|ENTPD3-AS1_ENST00000425156.1_RNA	NM_001248.2	NP_001239.2	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase 3	143						integral to membrane	ATP binding|hydrolase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		GCTGGGATGCGCTTGCTGAGG	0.502000													16	20					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66467646	66467646	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:66467646G>A	ENST00000383703.3	-	4	1013	c.410C>T	c.(409-411)gCc>gTc	p.A137V	LRIG1_ENST00000273261.3_Missense_Mutation_p.A137V			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	137						integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GGAAAGGTAGGCCTTCAGCTG	0.488000													55	95					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40085893	40085893	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:40085893C>T	ENST00000324616.5	+	11	1544	c.1390C>T	c.(1390-1392)Cga>Tga	p.R464*	C12orf40_ENST00000405531.3_Nonsense_Mutation_p.R464*	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	464										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						AAAAAGCAAGCGAATATCTAC	0.244000													8	28					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109805882	109805882	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109805882C>T	ENST00000271332.3	+	8	4888	c.4827C>T	c.(4825-4827)tgC>tgT	p.C1609C		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1609	EGF-like 4; calcium-binding.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GCAAGAGCTGCGCCCAGGGTA	0.647000													16	14					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158669921	158669921	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158669921T>C	ENST00000359610.2	-	1	565	c.522A>G	c.(520-522)gaA>gaG	p.E174E		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					AGAAGATATGTTCAAGGTGAT	0.488000													21	33					0	0	1	0	0
MEF2D	4209	broad.mit.edu	37	1	156438739	156438739	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156438739A>G	ENST00000348159.4	-	10	1560	c.1080T>C	c.(1078-1080)aaT>aaC	p.N360N	MEF2D_ENST00000360595.3_Silent_p.N353N|MEF2D_ENST00000340875.5_Silent_p.N359N|MEF2D_ENST00000353795.3_Silent_p.N314N|MEF2D_ENST00000368240.2_Silent_p.N353N|MEF2D_ENST00000464356.1_Intron	NM_005920.2	NP_005911.1	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	360					apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	15	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGCAGTGACATTGCCTAGCG	0.607000													18	14					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206590772	206590772	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:206590772C>T	ENST00000360409.3	+	6	1747	c.956C>T	c.(955-957)aCc>aTc	p.T319I	NRP2_ENST00000540841.1_Missense_Mutation_p.T319I|NRP2_ENST00000357118.4_Missense_Mutation_p.T319I|NRP2_ENST00000272849.3_Missense_Mutation_p.T319I|NRP2_ENST00000357785.5_Missense_Mutation_p.T319I|NRP2_ENST00000417189.1_Missense_Mutation_p.T319I|NRP2_ENST00000540178.1_Missense_Mutation_p.T319I|NRP2_ENST00000412873.2_Missense_Mutation_p.T319I|NRP2_ENST00000355117.4_Missense_Mutation_p.T319I	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	319	F5/8 type C 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						AATGGCTGGACCCCCAACTTG	0.522000													17	28					0	0	1	0	0
GADL1	339896	broad.mit.edu	37	3	30880563	30880563	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:30880563C>T	ENST00000454381.3	-	9	875	c.829G>A	c.(829-831)Gtg>Atg	p.V277M	GADL1_ENST00000282538.5_Missense_Mutation_p.V277M			Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	277					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding			breast(2)|endometrium(3)|kidney(2)|lung(17)|upper_aerodigestive_tract(1)	25					Pyridoxal Phosphate(DB00114)	GCTCCCAACACAGTTGTACCA	0.448000													17	35					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116046009	116046009	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:116046009G>A	ENST00000603594.1	+	11	1630	c.1309G>A	c.(1309-1311)Gcc>Acc	p.A437T	VWA2_ENST00000392982.3_Missense_Mutation_p.A437T	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	437	VWFA 2.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		CTTCGGGAGCGCCACCAGGAC	0.677000													22	22					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5862274	5862274	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5862274G>T	ENST00000329322.5	-	1	853	c.854C>A	c.(853-855)cCt>cAt	p.P285H	OR52E6_ENST00000379946.2_Missense_Mutation_p.P289H|TRIM5_ENST00000380027.1_Intron	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGGGTGGGAGGAACAACCAC	0.403000													22	44					7.41877e-09	7.84611e-09	1	1	0
ARPC5L	81873	broad.mit.edu	37	9	127637403	127637403	+	Silent	SNP	C	C	T	rs145806785		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:127637403C>T	ENST00000353214.2	+	5	1624	c.372C>T	c.(370-372)agC>agT	p.S124S	ARPC5L_ENST00000465124.1_3'UTR|ARPC5L_ENST00000259477.6_Silent_p.S124S			Q9BPX5	ARP5L_HUMAN	actin related protein 2/3 complex, subunit 5-like	124					regulation of actin filament polymerization	cytoplasm|cytoskeleton	actin binding			large_intestine(2)|lung(1)	3						AAAATAGCAGCGCAGTGTTAC	0.512000													28	43					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653200	159653200	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:159653200G>A	ENST00000297267.9	+	11	1856	c.1656G>A	c.(1654-1656)tcG>tcA	p.S552S	FNDC1_ENST00000340366.6_Silent_p.S489S	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	552						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GGGAGGACTCGCCCATGTCAC	0.632000													6	13					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47560306	47560306	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47560306C>T	ENST00000334194.3	+	7	844	c.841C>T	c.(841-843)Cgc>Tgc	p.R281C		NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	281						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						TCAGAAAAGGCGCTGGGATTT	0.358000													26	28					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31537346	31537346	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:31537346G>A	ENST00000261592.5	-	8	1669	c.1372C>T	c.(1372-1374)Cgt>Tgt	p.R458C	NOL4_ENST00000535384.1_Missense_Mutation_p.R173C|NOL4_ENST00000589544.1_Intron|NOL4_ENST00000538587.1_Missense_Mutation_p.R384C|NOL4_ENST00000269185.4_Intron|NOL4_ENST00000535475.1_Intron	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	458						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						GTACGTATACGTTTTCTGGCA	0.453000													20	36					0	0	1	0	0
USP14	9097	broad.mit.edu	37	18	198100	198100	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:198100C>T	ENST00000261601.6	+	9	820	c.729C>T	c.(727-729)atC>atT	p.I243I	USP14_ENST00000582707.1_Silent_p.I208I|USP14_ENST00000383589.2_Silent_p.I197I|USP14_ENST00000400266.3_Silent_p.I232I	NM_005151.3	NP_005142.1	P54578	UBP14_HUMAN	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	243					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(2)	11		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				AAAGTTTAATCGATCAGTTCT	0.323000													21	38					0	0	1	0	0
STRAP	11171	broad.mit.edu	37	12	16053889	16053889	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:16053889A>G	ENST00000419869.2	+	9	1247	c.934A>G	c.(934-936)Agt>Ggt	p.S312G	STRAP_ENST00000025399.6_Missense_Mutation_p.S325G|STRAP_ENST00000538352.1_Missense_Mutation_p.S218G	NM_007178.3	NP_009109.3	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated protein	312					mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|skin(1)	15		Hepatocellular(102;0.121)				AGAAGAAGATAGTGGTGAGCT	0.363000													15	24					0	0	1	0	0
FAM118B	79607	broad.mit.edu	37	11	126126678	126126678	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:126126678G>T	ENST00000533050.1	+	7	1406	c.913G>T	c.(913-915)Gat>Tat	p.D305Y	FAM118B_ENST00000360194.4_Missense_Mutation_p.D305Y	NM_024556.3	NP_078832.1	Q9BPY3	F118B_HUMAN	family with sequence similarity 118, member B	305										breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)	13	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		CTCCTATGGAGATGACTATGC	0.443000													67	113					3.28615e-30	3.68232e-30	1	1	0
ANK2	287	broad.mit.edu	37	4	114278013	114278013	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:114278013C>A	ENST00000357077.4	+	38	8292	c.8239C>A	c.(8239-8241)Cgt>Agt	p.R2747S	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.R2714S|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2714					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGCTGAAGACCGTCATGCTGT	0.418000													21	50					7.45023e-12	8.03714e-12	1	1	0
DNAH1	25981	broad.mit.edu	37	3	52422840	52422840	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52422840G>A	ENST00000420323.2	+	59	9643	c.9382G>A	c.(9382-9384)Gat>Aat	p.D3128N		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3193					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGGGCTGTCGGATGAGAAGGT	0.662000													16	21					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27761416	27761416	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:27761416G>A	ENST00000261588.4	+	16	3154	c.3135G>A	c.(3133-3135)atG>atA	p.M1045I		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1045										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						AGGATGACATGCATGTCTGGC	0.557000													10	19					0	0	1	0	0
MCMDC2	157777	broad.mit.edu	37	8	67796214	67796214	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:67796214C>T	ENST00000422365.2	+	9	1229	c.1058C>T	c.(1057-1059)aCt>aTt	p.T353I	MCMDC2_ENST00000396592.3_Missense_Mutation_p.T353I|MCMDC2_ENST00000492775.1_Missense_Mutation_p.T353I|MCMDC2_ENST00000541540.1_Missense_Mutation_p.T290I|MCMDC2_ENST00000313616.5_Missense_Mutation_p.T353I	NM_173518.4	NP_775789.3	Q4G0Z9	CH045_HUMAN	minichromosome maintenance domain containing 2	353					DNA replication		ATP binding|DNA binding			endometrium(2)|kidney(2)|lung(5)	9						ACAAGTGATACTCTACTCATA	0.333000													17	33					0	0	1	0	0
ZNF233	353355	broad.mit.edu	37	19	44777926	44777926	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44777926A>G	ENST00000391958.2	+	5	1240	c.1113A>G	c.(1111-1113)acA>acG	p.T371T	ZNF233_ENST00000592581.1_3'UTR|ZNF233_ENST00000334152.1_Silent_p.T353T|ZNF235_ENST00000589799.1_Intron	NM_181756.2	NP_861421.2	A6NK53	ZN233_HUMAN	zinc finger protein 233	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				AGTTGTGTACATGTGGCAGGT	0.473000													21	23					0	0	1	0	0
ITGA3	3675	broad.mit.edu	37	17	48166588	48166588	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48166588C>T	ENST00000007722.7	+	25	3160	c.3160C>T	c.(3160-3162)Cac>Tac	p.H1054Y	ITGA3_ENST00000320031.8_3'UTR			P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						CACCAAGAAGCACTGGGTGAC	0.597000													24	27					0	0	1	0	0
RSPH4A	345895	broad.mit.edu	37	6	116949448	116949448	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:116949448C>T	ENST00000229554.5	+	3	1715	c.1578C>T	c.(1576-1578)aaC>aaT	p.N526N	RSPH4A_ENST00000368581.4_Silent_p.N526N|RSPH4A_ENST00000368580.4_Intron	NM_001010892.2	NP_001010892.1	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A (Chlamydomonas)	526	Glu-rich.				cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke				breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						TTGAGGAAAACCCTGATTTTG	0.458000									Kartagener syndrome				4	121					0	0	1	0	0
CLCNKA	0	broad.mit.edu	37	1	16353830	16353830	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16353830G>A	ENST00000375692.1	+	9	809	c.681G>A	c.(679-681)atG>atA	p.M227I	CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000331433.4_Missense_Mutation_p.M227I|CLCNKA_ENST00000439316.2_Missense_Mutation_p.M184I|CLCNKA_ENST00000420078.1_Missense_Mutation_p.M227I			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	227					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	TCGAGGTCATGTCTTCCCACT	0.642000													25	99					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70450987	70450987	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:70450987C>T	ENST00000327305.6	-	7	1451	c.794G>A	c.(793-795)gGg>gAg	p.G265E	NETO1_ENST00000583169.1_Missense_Mutation_p.G265E|NETO1_ENST00000299430.2_Missense_Mutation_p.G264E	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	265	CUB 2.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GCGGATCACCCCAAGACCCGT	0.468000													35	80					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56745142	56745142	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56745142G>A	ENST00000314128.4	-	9	898	c.875C>T	c.(874-876)cCt>cTt	p.P292L	STAT2_ENST00000418572.2_Missense_Mutation_p.P288L|STAT2_ENST00000557235.1_Missense_Mutation_p.P288L			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	292					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						TTTGGTCAGAGGGTCATCCTG	0.572000													64	89					0	0	1	0	0
ZNF510	22869	broad.mit.edu	37	9	99521387	99521387	+	Silent	SNP	G	G	A	rs138732302		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:99521387G>A	ENST00000375231.1	-	6	2375	c.1725C>T	c.(1723-1725)aaC>aaT	p.N575N	ZNF510_ENST00000223428.4_Silent_p.N575N			Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	21		Acute lymphoblastic leukemia(62;0.0527)				TCCCACATTCGTTACATTTGA	0.388000													34	63					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65344584	65344584	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:65344584C>T	ENST00000284037.5	+	19	2267	c.1878C>T	c.(1876-1878)gtC>gtT	p.V626V	ERBB2IP_ENST00000380935.1_Silent_p.V626V|ERBB2IP_ENST00000380939.2_Silent_p.V626V|ERBB2IP_ENST00000380936.1_Silent_p.V626V|ERBB2IP_ENST00000416865.2_Intron|ERBB2IP_ENST00000511297.1_Silent_p.V622V|ERBB2IP_ENST00000380938.2_Silent_p.V626V|ERBB2IP_ENST00000380943.2_Silent_p.V626V|ERBB2IP_ENST00000506030.1_Silent_p.V626V|ERBB2IP_ENST00000508515.1_Silent_p.V626V	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	626					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AGCCAAAAGTCGTAGCACTTA	0.313000													25	35					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42119708	42119708	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:42119708G>A	ENST00000502486.1	-	6	2011	c.1432C>T	c.(1432-1434)Ccc>Tcc	p.P478S	BEND4_ENST00000504360.1_3'UTR	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	478	BEN.									NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						TCTTCCGAGGGCATCCACCAA	0.493000													3	7					0	0	1	0	0
RUVBL2	10856	broad.mit.edu	37	19	49507653	49507653	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49507653G>A	ENST00000413176.2	+	4	1256	c.108G>A	c.(106-108)acG>acA	p.T36T	RUVBL2_ENST00000595090.1_Silent_p.T81T|RUVBL2_ENST00000601968.1_Silent_p.T36T			Q9Y230	RUVB2_HUMAN	RuvB-like AAA ATPase 2	81					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding			large_intestine(1)|upper_aerodigestive_tract(1)	2		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		AGCCGGGCACGGGGAAGACGG	0.617000													7	57					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848230	215848230	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:215848230G>A	ENST00000366943.2	-	63	13409	c.13023C>T	c.(13021-13023)tgC>tgT	p.C4341C	USH2A_ENST00000307340.3_Silent_p.C4341C			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4341	Fibronectin type-III 28.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGCTGGTGGAGCATCCTCCAC	0.488000										HNSCC(13;0.011)			7	76					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179641415	179641415	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179641415G>A	ENST00000589042.1	-	28	5400	c.5176C>T	c.(5176-5178)Cta>Tta	p.L1726L	TTN_ENST00000342175.6_Silent_p.L1680L|TTN_ENST00000360870.5_Silent_p.L1726L|TTN_ENST00000591111.1_Silent_p.L1726L|TTN_ENST00000460472.2_Silent_p.L1680L|TTN_ENST00000342992.6_Silent_p.L1726L|TTN_ENST00000359218.5_Silent_p.L1680L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1480	Ig-like 8.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGGGTGTTAGCCTGCATTCA	0.453000													8	43					0	0	1	0	0
ZNF395	55893	broad.mit.edu	37	8	28218608	28218608	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:28218608G>A	ENST00000344423.5	-	2	165	c.34C>T	c.(34-36)Cgg>Tgg	p.R12W	ZNF395_ENST00000523095.1_Missense_Mutation_p.R12W|ZNF395_ENST00000523202.1_Missense_Mutation_p.R12W	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	12					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		AGGAGGGACCGCTTTCCAAGG	0.697000													10	22					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56223303	56223303	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56223303G>A	ENST00000332836.2	-	8	2733	c.2706C>T	c.(2704-2706)tgC>tgT	p.C902C		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	902						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CGATGTCGTCGCAGCAGGCAC	0.567000													16	19					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151491123	151491123	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151491123C>T	ENST00000271636.7	+	2	261	c.128C>T	c.(127-129)gCt>gTt	p.A43V		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	37	Head.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			CGACGCCCAGCTAAGGATGCA	0.612000													21	35					0	0	1	0	0
AP1AR	55435	broad.mit.edu	37	4	113189305	113189305	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:113189305A>C	ENST00000274000.5	+	10	1004	c.649A>C	c.(649-651)Aat>Cat	p.N217H	AP1AR_ENST00000309703.6_Missense_Mutation_p.N184H	NM_018569.4	NP_061039.3	Q63HQ0	AP1AR_HUMAN	adaptor-related protein complex 1 associated regulatory protein	217					protein transport	early endosome|Golgi apparatus|late endosome|transport vesicle				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)	9						CATAGGAATGAATAGAATGCT	0.328000													15	24					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28510859	28510859	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28510859G>A	ENST00000261609.7	-	14	1883	c.1775C>T	c.(1774-1776)gCc>gTc	p.A592V		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	592					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CATCGGAATGGCCTCGTCCTC	0.572000													18	18					0	0	1	0	0
APBB1	322	broad.mit.edu	37	11	6432426	6432426	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6432426C>T	ENST00000389906.2	-	2	251	c.152G>A	c.(151-153)cGc>cAc	p.R51H	APBB1_ENST00000533407.1_Intron|APBB1_ENST00000311051.3_Missense_Mutation_p.R51H|APBB1_ENST00000299402.6_Missense_Mutation_p.R51H	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	51					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CATGGCGCTGCGCAGGTCCTT	0.697000													42	64					0	0	1	0	0
ZNF205	7755	broad.mit.edu	37	16	3165366	3165366	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3165366G>A	ENST00000382192.3	+	3	273	c.68G>A	c.(67-69)cGt>cAt	p.R23H	ZNF205-AS1_ENST00000572691.1_RNA|ZNF205_ENST00000219091.4_Missense_Mutation_p.R23H	NM_001278158.1|NM_003456.2	NP_001265087.1|NP_003447.2	O95201	ZN205_HUMAN	zinc finger protein 205	23					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20						GTTCCAGATCGTGGACATCCT	0.582000													26	38					0	0	1	0	0
SGOL1	151648	broad.mit.edu	37	3	20216081	20216081	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:20216081G>A	ENST00000412997.1	-	6	1293	c.942C>T	c.(940-942)agC>agT	p.S314S	SGOL1_ENST00000452020.1_Intron|SGOL1_ENST00000263753.4_Silent_p.S314S|SGOL1-AS1_ENST00000441442.1_RNA|SGOL1_ENST00000412868.1_Silent_p.S314S|SGOL1_ENST00000443724.1_Intron|SGOL1_ENST00000306698.2_Intron|SGOL1_ENST00000437051.1_Intron|SGOL1_ENST00000425061.1_Intron|SGOL1_ENST00000421451.1_Silent_p.S314S|SGOL1_ENST00000383774.1_Intron|SGOL1_ENST00000419233.2_Intron|SGOL1_ENST00000417364.1_Intron|SGOL1-AS1_ENST00000448208.1_RNA|SGOL1_ENST00000429446.3_Intron|SGOL1_ENST00000442720.1_Intron	NM_001199251.1	NP_001186180.1	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 (S. pombe)	314					attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding			kidney(1)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(2)	14						ttttattttcgcttttattct	0.303000													19	29					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224482013	224482013	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:224482013G>A	ENST00000281701.6	-	12	1540	c.1281C>T	c.(1279-1281)gaC>gaT	p.D427D	NVL_ENST00000482491.1_Silent_p.D151D|NVL_ENST00000340871.4_Silent_p.D238D|NVL_ENST00000361463.3_Silent_p.D321D|NVL_ENST00000469075.1_Silent_p.D336D|NVL_ENST00000391875.2_Silent_p.D321D	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	427						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		ATATTTCTCGGTCGAACCTTC	0.448000													24	38					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53456223	53456223	+	Missense_Mutation	SNP	G	G	A	rs142568866	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53456223G>A	ENST00000314250.6	+	24	4021	c.3731G>A	c.(3730-3732)cGc>cAc	p.R1244H	TENC1_ENST00000451358.1_Missense_Mutation_p.R1234H|TENC1_ENST00000546602.1_Missense_Mutation_p.R1147H|TENC1_ENST00000549700.1_Missense_Mutation_p.R1179H|TENC1_ENST00000552570.1_Missense_Mutation_p.R1244H|TENC1_ENST00000379902.3_Missense_Mutation_p.R1120H|TENC1_ENST00000314276.3_Missense_Mutation_p.R1254H	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	1244	SH2.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						TGCTGCCTGCGCATTCCCAGC	0.632000													4	81					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5204860	5204860	+	Missense_Mutation	SNP	C	C	T	rs142723764	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:5204860C>T	ENST00000334314.3	-	2	293	c.217G>A	c.(217-219)Gct>Act	p.A73T						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						GTACCATCAGCGATCTTCTCC	0.443000													4	141					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74091286	74091286	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:74091286G>A	ENST00000443185.2	-	4	3101	c.2784C>T	c.(2782-2784)agC>agT	p.S928S	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	928					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		TAGGGGTGGCGCTCCTGCTGA	0.726000													19	16					0	0	1	0	0
ZNF561	93134	broad.mit.edu	37	19	9721558	9721558	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9721558T>A	ENST00000302851.3	-	6	1142	c.779A>T	c.(778-780)aAa>aTa	p.K260I	ZNF561_ENST00000354661.4_Missense_Mutation_p.K124I|ZNF561_ENST00000424629.1_Missense_Mutation_p.K191I|ZNF561_ENST00000326044.5_3'UTR	NM_152289.2	NP_689502.2	Q8N587	ZN561_HUMAN	zinc finger protein 561	260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	14						AGTGAAGGATTTCCCACATTT	0.373000													14	60					0	0	1	0	0
FAM166A	401565	broad.mit.edu	37	9	140139876	140139876	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140139876C>T	ENST00000344774.4	-	3	459	c.405G>A	c.(403-405)ccG>ccA	p.P135P	FAM166A_ENST00000388932.2_Silent_p.P135P	NM_001001710.1	NP_001001710.1	Q6J272	F166A_HUMAN	family with sequence similarity 166, member A	135										kidney(3)|lung(7)|ovary(2)|prostate(1)|urinary_tract(2)	15						ACGGAGGGTGCGGGGTGTCGG	0.647000													26	47					0	0	1	0	0
TAF5L	27097	broad.mit.edu	37	1	229730363	229730363	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:229730363G>A	ENST00000258281.2	-	5	1616	c.1451C>T	c.(1450-1452)gCg>gTg	p.A484V	TAF5L_ENST00000366676.1_Missense_Mutation_p.A484V	NM_014409.3	NP_055224.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	484					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				GCCAGCAGACGCCAAGTACTT	0.587000													33	57					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50962223	50962223	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50962223G>A	ENST00000357701.5	+	22	2606	c.2555G>A	c.(2554-2556)cGc>cAc	p.R852H		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	852	Ig-like C2-type 6.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle	p.R852H(1)		breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		ACCTACATCCGCAAAGTGGGC	0.697000													7	7					0	0	1	0	0
CLDN18	51208	broad.mit.edu	37	3	137717905	137717905	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:137717905C>T	ENST00000343735.4	+	1	329	c.195C>T	c.(193-195)ggC>ggT	p.G65G		NM_001002026.2	NP_001002026.1	P56856	CLD18_HUMAN	claudin 18	65					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	6						AGTGCCGGGGCTACTTCACCC	0.607000													21	29					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75140771	75140771	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:75140771C>T	ENST00000356357.4	-	9	1639	c.1124G>A	c.(1123-1125)cGc>cAc	p.R375H	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		GGTGTAAAGGCGCCAGGGGAT	0.438000													10	16					0	0	1	0	0
ASRGL1	80150	broad.mit.edu	37	11	62156640	62156640	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62156640G>A	ENST00000415229.2	+	5	742	c.527G>A	c.(526-528)tGc>tAc	p.C176Y	ASRGL1_ENST00000301776.5_Missense_Mutation_p.C176Y|ASRGL1_ENST00000535727.1_Missense_Mutation_p.C48Y	NM_001083926.1	NP_001077395.1	Q7L266	ASGL1_HUMAN	asparaginase like 1	176					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	7					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	GCCTTGGACTGCAAAGGGAAT	0.483000													57	77					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85279775	85279775	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:85279775C>A	ENST00000440886.1	-	2	854	c.816G>T	c.(814-816)caG>caT	p.Q272H	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Missense_Mutation_p.Q272H			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	272					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						TTTTCACATGCTGCACGCCAC	0.587000													23	26					2.44723e-14	2.66926e-14	1	1	0
SHISA3	152573	broad.mit.edu	37	4	42403327	42403327	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:42403327G>A	ENST00000319234.4	+	2	794	c.576G>A	c.(574-576)ccG>ccA	p.P192P		NM_001080505.1	NP_001073974.1	A0PJX4	SHSA3_HUMAN	shisa family member 3	192	Poly-Pro.				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	12						TGCCCTCACCGCCCCCGCCAT	0.662000													18	22					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105945830	105945830	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:105945830G>A	ENST00000357060.3	-	15	2027	c.1912C>T	c.(1912-1914)Cag>Tag	p.Q638*	WDR96_ENST00000278064.2_Nonsense_Mutation_p.Q569*|WDR96_ENST00000428666.1_Nonsense_Mutation_p.Q639*	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	638										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GGTCCATACTGTCTGCTTTGT	0.373000													14	76					0	0	1	0	0
HK1	3098	broad.mit.edu	37	10	71151991	71151991	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:71151991G>A	ENST00000448642.2	+	20	2640	c.2251G>A	c.(2251-2253)Ggg>Agg	p.G751R	HK1_ENST00000404387.2_Missense_Mutation_p.G720R|HK1_ENST00000298649.3_Missense_Mutation_p.G715R|HK1_ENST00000360289.2_Missense_Mutation_p.G704R|HK1_ENST00000359426.6_Missense_Mutation_p.G716R			P19367	HXK1_HUMAN	hexokinase 1	716	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						TGGGGACAACGGGTGTCTGGA	0.547000											OREG0020217	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	27					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33411028	33411028	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33411028C>T	ENST00000418600.2	+	15	2800	c.2699C>T	c.(2698-2700)aCg>aTg	p.T900M	SYNGAP1_ENST00000428982.2_Missense_Mutation_p.T841M|SYNGAP1_ENST00000293748.5_Missense_Mutation_p.T900M|SYNGAP1_ENST00000496374.1_3'UTR	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	900					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						TCATCCATCACGGCGGCTGGC	0.667000													22	41					0	0	1	0	0
TPT1	7178	broad.mit.edu	37	13	45913709	45913709	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:45913709G>A	ENST00000379056.1	-	3	390	c.220C>T	c.(220-222)Cca>Tca	p.P74S	TPT1_ENST00000530705.1_Missense_Mutation_p.P108S|TPT1_ENST00000379055.1_Missense_Mutation_p.P74S|TPT1_ENST00000379060.4_Missense_Mutation_p.P96S|TPT1_ENST00000529421.1_5'UTR|TPT1_ENST00000309246.5_Missense_Mutation_p.P108S			P13693	TCTP_HUMAN	tumor protein, translationally-controlled 1	108					anti-apoptosis|response to virus	extracellular space|multivesicular body	calcium ion binding|protein binding			lung(1)	1		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000232)		ACTCTTTCTGGTCTCTGTTCT	0.308000													25	96					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78942929	78942929	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:78942929C>T	ENST00000545128.1	+	32	4801	c.4263C>T	c.(4261-4263)tgC>tgT	p.C1421C		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	670					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						CCACAGATTGCCACAAGTCCT	0.587000													35	74					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126740951	126740951	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:126740951G>A	ENST00000251772.4	+	21	4062	c.3993G>A	c.(3991-3993)tcG>tcA	p.S1331S	PLXNA1_ENST00000393409.2_Silent_p.S1354S			Q9UIW2	PLXA1_HUMAN	plexin A1	1354					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		TGGAGAAGTCGCTGACACTGT	0.632000													8	13					0	0	1	0	0
ACSL6	23305	broad.mit.edu	37	5	131312359	131312359	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:131312359G>A	ENST00000379264.2	-	10	1080	c.972C>T	c.(970-972)ggC>ggT	p.G324G	ACSL6_ENST00000379246.1_Silent_p.G310G|ACSL6_ENST00000379272.2_Silent_p.G314G|ACSL6_ENST00000379244.1_Silent_p.G299G|ACSL6_ENST00000543479.1_Silent_p.G299G|ACSL6_ENST00000544770.1_Silent_p.G208G|ACSL6_ENST00000379255.1_Silent_p.G264G|ACSL6_ENST00000431707.1_Silent_p.G279G|ACSL6_ENST00000379249.3_Silent_p.G299G|ACSL6_ENST00000379240.1_Silent_p.G299G|ACSL6_ENST00000296869.4_Silent_p.G324G|ACSL6_ENST00000357096.1_Silent_p.G264G	NM_001009185.2	NP_001009185.1	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	299					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTTCAGAAAGCCTGAGAAAT	0.418000													31	21					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70954766	70954766	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:70954766G>A	ENST00000393567.2	-	46	7663	c.7513C>T	c.(7513-7515)Cgc>Tgc	p.R2505C		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2505										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CGGCCCCTGCGCCCACCCAAG	0.687000													3	9					0	0	1	0	0
RBM14	10432	broad.mit.edu	37	11	66393086	66393086	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66393086G>A	ENST00000310137.4	+	2	1878	c.1739G>A	c.(1738-1740)cGc>cAc	p.R580H	RBM14-RBM4_ENST00000412278.2_Intron|RBM14_ENST00000409738.4_Intron|RBM14-RBM4_ENST00000500635.2_Intron|RBM4_ENST00000514361.3_Intron|RBM14_ENST00000393979.3_Intron|RBM4_ENST00000503028.2_Intron	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	580					DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						GAGCGTACCCGCCTCTCCCCA	0.667000													12	10					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1957028	1957028	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1957028G>A	ENST00000382895.3	+	15	2910	c.2479G>A	c.(2479-2481)Gcc>Acc	p.A827T	WHSC1_ENST00000508803.1_Missense_Mutation_p.A827T|WHSC1_ENST00000382891.5_Missense_Mutation_p.A827T|WHSC1_ENST00000382892.2_Missense_Mutation_p.A827T|WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Missense_Mutation_p.A175T	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	827					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GCGACACCACGCCCACGTCAA	0.612000			T	IGH@	MM								11	16					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31021232	31021232	+	Missense_Mutation	SNP	C	C	T	rs148964601		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31021232C>T	ENST00000375687.4	+	12	1655	c.1231C>T	c.(1231-1233)Cgc>Tgc	p.R411C	ASXL1_ENST00000306058.5_Missense_Mutation_p.R406C	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	411					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						TTTTAAGAAACGCTCTCGGCC	0.517000			"""F, N, Mis"""		"""MDS, CMML"""								26	27					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58109158	58109158	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58109158C>T	ENST00000357272.4	+	21	3630	c.3465C>T	c.(3463-3465)agC>agT	p.S1155S	FLNB_ENST00000490882.1_Silent_p.S1155S|FLNB_ENST00000295956.4_Silent_p.S1155S|FLNB_ENST00000493452.1_Silent_p.S986S|FLNB_ENST00000358537.3_Silent_p.S1155S|FLNB_ENST00000429972.2_Silent_p.S1155S|FLNB_ENST00000419752.2_Silent_p.S986S|FLNB_ENST00000348383.5_Silent_p.S1155S			O75369	FLNB_HUMAN	filamin B, beta	1155	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GCCTCCTTAGCGTCGACTGCT	0.582000													27	49					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103293668	103293668	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:103293668G>A	ENST00000520539.1	-	41	6382	c.5776C>T	c.(5776-5778)Cgg>Tgg	p.R1926W	UBR5_ENST00000220959.4_Missense_Mutation_p.R1926W|UBR5_ENST00000521922.1_Missense_Mutation_p.R1920W	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1926					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TTATGAGACCGCATTAGAGAC	0.408000													31	36					0	0	1	0	0
VPS53	55275	broad.mit.edu	37	17	526886	526886	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:526886T>C	ENST00000437048.2	-	11	1149	c.1003A>G	c.(1003-1005)Aga>Gga	p.R335G	VPS53_ENST00000571805.1_Missense_Mutation_p.R335G|VPS53_ENST00000291074.5_Missense_Mutation_p.R306G|VPS53_ENST00000576149.1_5'UTR|VPS53_ENST00000574029.1_Intron|VPS53_ENST00000401468.3_Intron|VPS53_ENST00000446250.2_Missense_Mutation_p.R137G	NM_001128159.2	NP_001121631.1	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 homolog (S. cerevisiae)	335					protein transport	endosome membrane|Golgi apparatus				breast(1)|endometrium(4)|large_intestine(5)|lung(8)|prostate(1)	19				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		TCCTTCGCTCTGGTACGCATA	0.403000													8	35					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24433672	24433672	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:24433672C>T	ENST00000355123.4	-	34	4677	c.4234G>A	c.(4234-4236)Gtg>Atg	p.V1412M	ITSN2_ENST00000361999.3_Missense_Mutation_p.V1385M	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	1412					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCACACTGCACGTGCGCCTGG	0.632000													11	26					0	0	1	0	0
SLC38A2	54407	broad.mit.edu	37	12	46757607	46757607	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:46757607C>T	ENST00000256689.5	-	12	1400	c.956G>A	c.(955-957)cGc>cAc	p.R319H	SLC38A2_ENST00000551374.1_Missense_Mutation_p.R157H	NM_018976.4	NP_061849.2	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	319					cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	18	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		TCTACGGCTGCGGCTATGTAA	0.333000													13	25					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30747622	30747622	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30747622T>C	ENST00000262518.4	+	32	7216	c.6831T>C	c.(6829-6831)ttT>ttC	p.F2277F	SRCAP_ENST00000344771.4_Silent_p.F2119F|SRCAP_ENST00000395059.2_Silent_p.F2215F	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2277	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			ACGATGGGTTTCCTGCTGGTG	0.572000													18	25					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124268552	124268552	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:124268552C>T	ENST00000409039.3	+	8	900	c.875C>T	c.(874-876)gCg>gTg	p.A292V		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	292	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACCTTAAGTGCGCTGCATGAA	0.443000													18	27					0	0	1	0	0
GPR119	139760	broad.mit.edu	37	X	129518840	129518840	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:129518840C>T	ENST00000276218.2	-	1	671	c.582G>A	c.(580-582)atG>atA	p.M194I		NM_178471.2	NP_848566.1	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	194						integral to membrane|plasma membrane	lipid binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(3)|prostate(1)	11						GCTGGCTGTGCATGGAGGCAA	0.542000													11	7					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104140469	104140469	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104140469A>G	ENST00000388887.2	+	58	6435	c.6231A>G	c.(6229-6231)ggA>ggG	p.G2077G	RP11-341G23.4_ENST00000551299.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	2077	EGF-like 15.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AAGGTGACGGAATCACATGCA	0.517000													38	101					0	0	1	0	0
SP4	6671	broad.mit.edu	37	7	21469853	21469853	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:21469853G>A	ENST00000222584.3	+	3	1288	c.1070G>A	c.(1069-1071)cGc>cAc	p.R357H		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	357					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						AGTTCTGAACGCACCATTGAA	0.483000													18	32					0	0	1	0	0
ZNF287	57336	broad.mit.edu	37	17	16455754	16455754	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:16455754C>T	ENST00000395824.1	-	6	2319	c.1702G>A	c.(1702-1704)Gaa>Aaa	p.E568K	ZNF287_ENST00000395825.3_Missense_Mutation_p.E568K			Q9HBT7	ZN287_HUMAN	zinc finger protein 287	561					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|prostate(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TTTCCACATTCATTACATTTA	0.353000													22	39					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70991600	70991600	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:70991600C>A	ENST00000256389.3	-	2	269	c.25G>T	c.(25-27)Gat>Tat	p.D9Y	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	0					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		ATCTGGGGATCTGTGTCCTGG	0.537000													46	50					3.21987e-24	3.59154e-24	1	1	0
TTC13	79573	broad.mit.edu	37	1	231067184	231067184	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:231067184C>T	ENST00000366661.4	-	11	1167	c.1160G>A	c.(1159-1161)tGc>tAc	p.C387Y	TTC13_ENST00000366662.4_Missense_Mutation_p.C334Y|TTC13_ENST00000414259.1_Missense_Mutation_p.C334Y	NM_024525.4	NP_078801.3	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13	387							binding			central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	39	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CATATACTGGCACACTTCATT	0.413000													30	44					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13087063	13087063	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:13087063C>T	ENST00000506447.1	+	31	5744	c.5664C>T	c.(5662-5664)ggC>ggT	p.G1888G	CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000325971.8_Silent_p.G1292G|CEP192_ENST00000430049.2_Silent_p.G1413G	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1483										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TTTTGGAAGGCGTTAAAAAAT	0.348000													17	36					0	0	1	0	0
RORA	6095	broad.mit.edu	37	15	60789757	60789757	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:60789757G>A	ENST00000335670.6	-	11	1569	c.1469C>T	c.(1468-1470)gCa>gTa	p.A490V	RORA_ENST00000449337.2_Missense_Mutation_p.A435V|RP11-219B17.1_ENST00000501579.2_RNA|RORA_ENST00000309157.4_Missense_Mutation_p.A515V|RP11-219B17.1_ENST00000558140.1_RNA|RP11-219B17.1_ENST00000559824.1_RNA|RORA_ENST00000261523.5_Missense_Mutation_p.A523V|RP11-219B17.1_ENST00000558235.1_RNA	NM_134261.2	NP_599023.1	P35398	RORA_HUMAN	RAR-related orphan receptor A	523	Ligand-binding.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	21						TGCTTTAAATGCCATTAGCTT	0.403000													13	60					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137852464	137852464	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:137852464C>T	ENST00000409968.1	+	4	1150	c.972C>T	c.(970-972)ttC>ttT	p.F324F	THSD7B_ENST00000272643.3_Silent_p.F324F|THSD7B_ENST00000543459.1_Silent_p.F183F|THSD7B_ENST00000413152.2_Silent_p.F293F					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AAGATTCCTTCCCATTGACTG	0.458000													27	47					0	0	1	0	0
EIF2B1	1967	broad.mit.edu	37	12	124106308	124106308	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:124106308G>T	ENST00000424014.2	-	9	1121	c.913C>A	c.(913-915)Ctg>Atg	p.L305M	EIF2B1_ENST00000539951.1_3'UTR	NM_001414.3	NP_001405.1	Q14232	EI2BA_HUMAN	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	305					cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity			breast(1)|kidney(3)|large_intestine(2)|lung(3)|urinary_tract(1)	10	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)		ACAGGTTACAGATAGAGCTTG	0.542000													15	20					5.03518e-11	5.40566e-11	1	1	0
NUP214	8021	broad.mit.edu	37	9	134049546	134049546	+	Missense_Mutation	SNP	C	C	T	rs79941555	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:134049546C>T	ENST00000359428.5	+	22	3142	c.2998C>T	c.(2998-3000)Cgg>Tgg	p.R1000W	NUP214_ENST00000451030.1_Missense_Mutation_p.R1001W|NUP214_ENST00000411637.2_Missense_Mutation_p.R990W			P35658	NU214_HUMAN	nucleoporin 214kDa	1000	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TGAAGATGCACGGACGTCCTG	0.557000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								20	56					0	0	1	0	0
PCDHB13	0	broad.mit.edu	37	5	140594169	140594169	+	Silent	SNP	C	C	T	rs151304777		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140594169C>T	ENST00000341948.4	+	1	661	c.474C>T	c.(472-474)gcC>gcT	p.A158A		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		158	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAAGAATGCCGAAGACTTAG	0.443000													28	66					0	0	1	0	0
TRAK2	66008	broad.mit.edu	37	2	202259538	202259538	+	Missense_Mutation	SNP	G	G	A	rs145122223		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:202259538G>A	ENST00000332624.3	-	9	1386	c.958C>T	c.(958-960)Cgg>Tgg	p.R320W		NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	320				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						GTCAGTTGCCGTTGGGCATCT	0.358000													5	41					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48738336	48738336	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48738336C>T	ENST00000285238.8	+	8	939	c.859C>T	c.(859-861)Ctg>Ttg	p.L287L	ABCC3_ENST00000427699.1_Silent_p.L287L	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	287					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GGACGAGGTGCTGCTGGGTGC	0.632000													12	24					0	0	1	0	0
CALU	813	broad.mit.edu	37	7	128407537	128407537	+	Missense_Mutation	SNP	C	C	T	rs150941182	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128407537C>T	ENST00000542996.2	+	7	1638	c.695C>T	c.(694-696)aCt>aTt	p.T232I	CALU_ENST00000449187.2_Missense_Mutation_p.T224I|CALU_ENST00000535011.2_Intron|CALU_ENST00000538546.1_Missense_Mutation_p.T73I|CALU_ENST00000535623.1_3'UTR|CALU_ENST00000249364.4_Missense_Mutation_p.T224I|CALU_ENST00000479257.1_Missense_Mutation_p.T232I	NM_001199672.1	NP_001186601.1	O43852	CALU_HUMAN	calumenin	224	EF-hand 5.				platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding			kidney(2)|large_intestine(3)|lung(5)	10						GATGGGAATACTGATGAGCCA	0.463000													23	35					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144946563	144946563	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144946563C>T	ENST00000525985.1	-	2	930	c.859G>A	c.(859-861)Gtg>Atg	p.V287M				P58107	EPIPL_HUMAN	epiplakin 1	287						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCCCGGCCACGCTGCCGGTA	0.682000													8	29					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3328517	3328517	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:3328517T>C	ENST00000378398.3	+	10	1841	c.1759T>C	c.(1759-1761)Tcc>Ccc	p.S587P	PRDM16_ENST00000442529.2_Missense_Mutation_p.S586P|PRDM16_ENST00000441472.2_Missense_Mutation_p.S586P|PRDM16_ENST00000514189.1_Missense_Mutation_p.S587P|PRDM16_ENST00000511072.1_Missense_Mutation_p.S587P|PRDM16_ENST00000378391.2_Missense_Mutation_p.S586P|PRDM16_ENST00000270722.5_Missense_Mutation_p.S586P|PRDM16_ENST00000512462.1_3'UTR			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	586					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CCTGGAGGACTCCTGTGTGGA	0.657000			T	EVI1	"""MDS, AML"""								25	32					0	0	1	0	0
RDX	5962	broad.mit.edu	37	11	110124753	110124753	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:110124753G>A	ENST00000343115.4	-	9	1196	c.877C>T	c.(877-879)Cga>Tga	p.R293*	RDX_ENST00000530301.1_Intron|RDX_ENST00000528900.1_Intron|RDX_ENST00000528498.1_Nonsense_Mutation_p.R293*|RDX_ENST00000405097.1_Nonsense_Mutation_p.R293*|RDX_ENST00000544551.1_Nonsense_Mutation_p.R157*	NM_001260494.1|NM_002906.3	NP_001247423.1|NP_002897.1	P35241	RADI_HUMAN	radixin	293	FERM.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	18		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		TTCCTTCTTCGCATGTATAGT	0.408000													4	45					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67576292	67576292	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67576292G>T	ENST00000540839.3	+	14	1883	c.1663G>T	c.(1663-1665)Gac>Tac	p.D555Y	CTD-2012K14.4_ENST00000564717.1_RNA|FAM65A_ENST00000428437.2_Missense_Mutation_p.D549Y|FAM65A_ENST00000042381.4_Missense_Mutation_p.D535Y|FAM65A_ENST00000379312.3_Missense_Mutation_p.D539Y|FAM65A_ENST00000422602.2_Missense_Mutation_p.D555Y|CTD-2012K14.3_ENST00000563083.1_RNA			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	539	Pro-rich.					cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		TAAGTCCACAGACTCTGGCCC	0.562000													10	177					1.08611e-07	1.14056e-07	1	1	0
OR5B12	390191	broad.mit.edu	37	11	58206930	58206930	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:58206930C>T	ENST00000302572.2	-	1	716	c.695G>A	c.(694-696)cGc>cAc	p.R232H		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GGCCTTCTGGCGTCCTTCAGG	0.418000													23	23					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39845971	39845971	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:39845971C>T	ENST00000564288.1	+	55	14351	c.13574C>T	c.(13573-13575)gCc>gTc	p.A4525V	MACF1_ENST00000567887.1_Missense_Mutation_p.A4562V|MACF1_ENST00000539005.1_Missense_Mutation_p.A2442V|MACF1_ENST00000372915.3_Missense_Mutation_p.A4530V|MACF1_ENST00000361689.2_Missense_Mutation_p.A2463V|MACF1_ENST00000317713.7_Missense_Mutation_p.A2463V|MACF1_ENST00000289893.4_Missense_Mutation_p.A2965V|MACF1_ENST00000545844.1_Missense_Mutation_p.A2463V			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	4530					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTAAAGGAAGCCCTGGCTGGA	0.418000													4	57					0	0	1	0	0
CCNJL	79616	broad.mit.edu	37	5	159680778	159680778	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:159680778G>A	ENST00000393977.3	-	7	1200	c.915C>T	c.(913-915)gcC>gcT	p.A305A	CCNJL_ENST00000257536.7_Silent_p.A257A|CCNJL_ENST00000377503.2_5'UTR	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	305						nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGACGGCTACGGCATCCTTGA	0.607000													13	23					0	0	1	0	0
HYLS1	219844	broad.mit.edu	37	11	125769528	125769528	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:125769528C>T	ENST00000425380.2	+	3	1046	c.265C>T	c.(265-267)Ctc>Ttc	p.L89F	HYLS1_ENST00000526028.1_Missense_Mutation_p.L89F|HYLS1_ENST00000356438.3_Missense_Mutation_p.L89F|PUS3_ENST00000227474.3_Intron	NM_001134793.1	NP_001128265.1	Q96M11	HYLS1_HUMAN	hydrolethalus syndrome 1	89						centrosome|nucleus				breast(1)|endometrium(1)|large_intestine(3)|skin(3)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		CTCCCAAAGACTCCGAAAGCC	0.483000													29	28					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17946739	17946739	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17946739G>A	ENST00000458235.1	-	14	2007	c.1908C>T	c.(1906-1908)aaC>aaT	p.N636N	JAK3_ENST00000534444.1_Silent_p.N636N|JAK3_ENST00000527670.1_Silent_p.N636N	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	636	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						TCACCAGATAGTTGAGGGCGT	0.572000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								8	16					0	0	1	0	0
NGLY1	55768	broad.mit.edu	37	3	25761538	25761538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:25761538G>A	ENST00000428257.1	-	11	1809	c.1702C>T	c.(1702-1704)Cga>Tga	p.R568*	NGLY1_ENST00000280700.5_Nonsense_Mutation_p.R586*|NGLY1_ENST00000422724.2_3'UTR|NGLY1_ENST00000417874.2_Nonsense_Mutation_p.R544*|NGLY1_ENST00000467224.1_Intron|NGLY1_ENST00000396649.3_Intron	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	586	PAW.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						GTATCAGATCGCAATTTCCAT	0.378000													28	38					0	0	1	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67221640	67221640	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67221640C>T	ENST00000314586.6	-	5	768	c.528G>A	c.(526-528)acG>acA	p.T176T	EXOC3L1_ENST00000562887.1_Intron	NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	176	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						GGGGTGCCCACGTATCCTCTC	0.632000													17	24					0	0	1	0	0
FBXO38	81545	broad.mit.edu	37	5	147813012	147813012	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:147813012C>T	ENST00000340253.5	+	16	2847	c.2679C>T	c.(2677-2679)caC>caT	p.H893H	FBXO38_ENST00000513826.1_Silent_p.H648H|FBXO38_ENST00000296701.6_Silent_p.H648H|FBXO38_ENST00000394370.3_Silent_p.H818H			Q6PIJ6	FBX38_HUMAN	F-box protein 38	893						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCACGTCACGCCATGAAAC	0.413000													18	34					0	0	1	0	0
SDC4	6385	broad.mit.edu	37	20	43956030	43956030	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:43956030G>A	ENST00000372733.3	-	5	510	c.471C>T	c.(469-471)ggC>ggT	p.G157G	SDC4_ENST00000537976.1_Silent_p.G85G	NM_002999.3	NP_002990.2	P31431	SDC4_HUMAN	syndecan 4	157						extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity		SDC4/ROS1(7)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)	5		Myeloproliferative disorder(115;0.0122)				CAAAGAGGATGCCCACGATGC	0.537000			T	ROS1	NSCLC								14	18					0	0	1	0	0
ALDH8A1	64577	broad.mit.edu	37	6	135263570	135263570	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:135263570G>A	ENST00000265605.2	-	3	487	c.419C>T	c.(418-420)aCg>aTg	p.T140M	ALDH8A1_ENST00000367845.2_Missense_Mutation_p.T140M|ALDH8A1_ENST00000367847.2_Missense_Mutation_p.T140M|RP11-349J5.2_ENST00000416448.2_RNA	NM_022568.3	NP_072090.1	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8 family, member A1	140					retinal metabolic process	cytoplasm	retinal dehydrogenase activity	p.T140M(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	36	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		GGCCCGCACCGTGTAGTGCAT	0.582000													3	34					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197707373	197707373	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:197707373C>T	ENST00000330198.4	+	6	748	c.726C>T	c.(724-726)gaC>gaT	p.D242D	LMLN_ENST00000482695.1_Silent_p.D190D|LMLN_ENST00000332636.5_Silent_p.D190D|LMLN_ENST00000420910.2_Silent_p.D242D	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	242					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CAAACATGGACAGGTAATCTT	0.418000													26	37					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685777	125685777	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:125685777C>T	ENST00000371126.1	-	1	1057	c.815G>A	c.(814-816)gGc>gAc	p.G272D		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	272										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						CTGGTTCTTGCCGCCGCAGGC	0.642000													11	5					0	0	1	0	0
AK8	158067	broad.mit.edu	37	9	135702253	135702253	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:135702253C>T	ENST00000298545.3	-	8	1266	c.745G>A	c.(745-747)Gtc>Atc	p.V249I	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	249						cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						TGGTAGAAGACGTCCACACAT	0.547000													27	53					0	0	1	0	0
PER1	5187	broad.mit.edu	37	17	8050579	8050579	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8050579G>A	ENST00000317276.4	-	13	1855	c.1618C>T	c.(1618-1620)Cct>Tct	p.P540S	PER1_ENST00000354903.5_Missense_Mutation_p.P524S|PER1_ENST00000581082.1_Missense_Mutation_p.P520S	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	540					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GGCGCAGGAGGCCCAGGCCCC	0.642000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					3	5					0	0	1	0	0
SH2D5	400745	broad.mit.edu	37	1	21052532	21052532	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:21052532G>A	ENST00000375031.1	-	4	643	c.19C>T	c.(19-21)Cgc>Tgc	p.R7C	SH2D5_ENST00000444387.2_Missense_Mutation_p.R91C|SH2D5_ENST00000460804.1_Intron	NM_001103160.1	NP_001096630.1	Q6ZV89	SH2D5_HUMAN	SH2 domain containing 5	7										lung(4)|prostate(1)|upper_aerodigestive_tract(1)	6		Colorectal(325;3.46e-05)|all_lung(284;5.32e-05)|Lung NSC(340;5.51e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|GBM - Glioblastoma multiforme(114;0.000465)|Kidney(64;0.000476)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(64;0.00634)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TAGAGTATGCGCCTCAGGGCA	0.647000													5	0					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13372388	13372388	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13372388C>T	ENST00000360228.5	-	26	4125	c.4126G>A	c.(4126-4128)Gtc>Atc	p.V1376I	CACNA1A_ENST00000573710.2_Missense_Mutation_p.V1377I	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1377					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ATGTTGAAGACGTTTTTAAGT	0.522000													3	8					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1391167	1391167	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1391167C>T	ENST00000324385.5	+	7	769	c.611C>T	c.(610-612)gCc>gTc	p.A204V	BAIAP3_ENST00000426824.3_Missense_Mutation_p.A169V|BAIAP3_ENST00000397488.2_Missense_Mutation_p.A186V|BAIAP3_ENST00000568887.1_Missense_Mutation_p.A141V|BAIAP3_ENST00000397489.1_Missense_Mutation_p.A186V|BAIAP3_ENST00000421665.2_Missense_Mutation_p.A169V|BAIAP3_ENST00000562208.1_Missense_Mutation_p.A146V	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	204	C2 1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				GTCATGCGTGCCAAGAACCTT	0.682000													12	17					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139820036	139820036	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:139820036C>T	ENST00000303045.6	-	10	1915	c.1469G>A	c.(1468-1470)gGc>gAc	p.G490D	COL22A1_ENST00000435777.1_Missense_Mutation_p.G490D	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	490	Collagen-like 1.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCCCATGGGGCCAGCAACTCC	0.443000										HNSCC(7;0.00092)			17	46					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32363886	32363886	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32363886G>A	ENST00000454136.3	-	5	1012	c.1008C>T	c.(1006-1008)gaC>gaT	p.D336D	BTNL2_ENST00000429232.2_Silent_p.D243D|BTNL2_ENST00000374993.1_Silent_p.D336D|BTNL2_ENST00000374995.3_Silent_p.D242D|BTNL2_ENST00000544175.1_Silent_p.D59D|BTNL2_ENST00000540315.1_Silent_p.D126D|BTNL2_ENST00000414363.1_Silent_p.D126D			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	336	Ig-like V-type 3.					integral to membrane		p.D336D(1)		central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						GGTACTGCCCGTCGTCCGAAG	0.493000													20	38					0	0	1	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33877564	33877564	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:33877564C>G	ENST00000307296.3	+	8	1240	c.863C>G	c.(862-864)gCa>gGa	p.A288G	PDCD6IP_ENST00000457054.2_Missense_Mutation_p.A293G			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	288	BRO1.|Interaction with CHMP4A, CHMP4B and CHMP4C.|Interaction with EIAV p9.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						AAAACAGTGGCATCTCGCTAT	0.353000													24	41					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177036436	177036436	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:177036436C>T	ENST00000468418.3	+	4	2823	c.733C>T	c.(733-735)Cgg>Tgg	p.R245W	HOXD3_ENST00000249440.3_Missense_Mutation_p.R245W|HOXD3_ENST00000410016.1_Missense_Mutation_p.R245W			P31249	HXD3_HUMAN	homeobox D3	245					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		GTTCCAGAACCGGCGCATGAA	0.637000													21	55					0	0	1	0	0
EPDR1	54749	broad.mit.edu	37	7	37988562	37988562	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:37988562C>T	ENST00000199448.4	+	2	769	c.390C>T	c.(388-390)aaC>aaT	p.N130N	EPDR1_ENST00000559325.1_Silent_p.N250N|EPDR1_ENST00000423717.1_Intron|EPDR1_ENST00000425345.1_Silent_p.N69N|EPDR1_ENST00000476620.1_Silent_p.N28N	NM_017549.4	NP_060019.2	Q9UM22	EPDR1_HUMAN	ependymin related 1	130					cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	22						TTCCTCAAAACTCCACCTTTG	0.512000													18	39					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87677941	87677941	+	Missense_Mutation	SNP	G	G	A	rs146321235		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:87677941G>A	ENST00000284262.2	+	2	702	c.460G>A	c.(460-462)Gcg>Acg	p.A154T		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	154					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		TGGCATGGCCGCGGTCATCCG	0.697000													27	34					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111685066	111685066	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:111685066G>A	ENST00000435970.1	-	18	7451	c.6635C>T	c.(6634-6636)gCt>gTt	p.A2212V	REV3L_ENST00000358835.3_Missense_Mutation_p.A2290V|REV3L_ENST00000368805.1_Missense_Mutation_p.A2290V|REV3L_ENST00000368802.3_Missense_Mutation_p.A2290V			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	2290					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTCATGTAAAGCTTTTGCCTC	0.338000								DNA polymerases (catalytic subunits)					12	28					0	0	1	0	0
CDC27	996	broad.mit.edu	37	17	45235647	45235647	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:45235647C>A	ENST00000066544.3	-	5	493	c.400G>T	c.(400-402)Gga>Tga	p.G134*	CDC27_ENST00000446365.2_Nonsense_Mutation_p.G73*|CDC27_ENST00000528748.1_5'UTR|CDC27_ENST00000531206.1_Nonsense_Mutation_p.G134*|CDC27_ENST00000527547.1_Nonsense_Mutation_p.G134*	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	134					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						CATTCTGATCCTTTGGCAAGC	0.388000													14	28					0.000308642	0.000314663	1	1	0
ERAP1	51752	broad.mit.edu	37	5	96119711	96119711	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:96119711C>T	ENST00000296754.3	-	14	2274	c.2017G>A	c.(2017-2019)Gtg>Atg	p.V673M	ERAP1_ENST00000514604.1_5'UTR|ERAP1_ENST00000443439.2_Missense_Mutation_p.V673M	NM_016442.3	NP_057526.3	Q9NZ08	ERAP1_HUMAN	endoplasmic reticulum aminopeptidase 1	673					angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			endometrium(7)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|stomach(2)	19		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		CCTTGAAACACGGGCATAATT	0.383000													21	34					0	0	1	0	0
ULK3	25989	broad.mit.edu	37	15	75134652	75134652	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75134652T>C	ENST00000440863.2	-	2	303	c.212A>G	c.(211-213)cAt>cGt	p.H71R	ULK3_ENST00000568667.1_Missense_Mutation_p.H82R|ULK3_ENST00000569437.1_Missense_Mutation_p.H71R	NM_001099436.1	NP_001092906.1	Q6PHR2	ULK3_HUMAN	unc-51 like kinase 3	71	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(2)	2						AATGTGGGGATGTCGAATGCC	0.557000													27	28					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47876928	47876928	+	Missense_Mutation	SNP	G	G	A	rs140114119		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47876928G>A	ENST00000328771.4	+	9	2384	c.2035G>A	c.(2035-2037)Gaa>Aaa	p.E679K		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	679						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TCGACTGTACGAAATGGCCAA	0.612000													5	12					0	0	1	0	0
MIER1	57708	broad.mit.edu	37	1	67411867	67411867	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:67411867T>A	ENST00000357692.2	+	5	377	c.120T>A	c.(118-120)gaT>gaA	p.D40E	MIER1_ENST00000371018.3_Missense_Mutation_p.D40E|MIER1_ENST00000371014.1_Missense_Mutation_p.D76E|MIER1_ENST00000401041.1_Missense_Mutation_p.D76E|MIER1_ENST00000355977.6_Intron|MIER1_ENST00000401042.3_Missense_Mutation_p.D23E|MIER1_ENST00000371012.2_Missense_Mutation_p.D40E|MIER1_ENST00000479067.1_3'UTR|MIER1_ENST00000355356.3_Missense_Mutation_p.D23E|MIER1_ENST00000371016.1_Missense_Mutation_p.D40E	NM_001146110.1	NP_001139582.1	Q8N108	MIER1_HUMAN	mesoderm induction early response 1, transcriptional regulator	47					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(3)	15						ATGAATTTGATCCATCAGCTG	0.343000													31	47					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42320929	42320929	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:42320929C>T	ENST00000217026.4	+	6	760	c.633C>T	c.(631-633)ggC>ggT	p.G211G	MYBL2_ENST00000396863.4_Silent_p.G187G	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	211						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACAAGGACGGCCTCCAGAGTG	0.547000													21	27					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192261212	192261212	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:192261212C>T	ENST00000392318.3	+	21	2531	c.2284C>T	c.(2284-2286)Cgg>Tgg	p.R762W	MYO1B_ENST00000339514.4_Missense_Mutation_p.R762W|MYO1B_ENST00000392316.1_Missense_Mutation_p.R762W|MYO1B_ENST00000304164.4_Missense_Mutation_p.R762W|MYO1B_ENST00000439065.2_Missense_Mutation_p.R36W	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	762	IQ 3.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GTCTTATATCCGGGGTTGGAA	0.393000													37	70					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13615222	13615222	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:13615222G>A	ENST00000040738.5	-	5	1373	c.1238C>T	c.(1237-1239)aCc>aTc	p.T413I		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	413	Lys-rich.						DNA binding										AAGGTCACTGGTATGAACAGA	0.368000													28	33					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32561826	32561826	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:32561826G>A	ENST00000345122.3	+	2	2266	c.1951G>A	c.(1951-1953)Gcc>Acc	p.A651T	ARHGAP5_ENST00000539826.2_Missense_Mutation_p.A651T|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000556611.1_Missense_Mutation_p.A651T|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000432921.1_Missense_Mutation_p.A651T	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	651					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		GTTATGGACTGCCGCCTTTAA	0.388000													27	77					0	0	1	0	0
NDRG1	10397	broad.mit.edu	37	8	134276793	134276793	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:134276793T>C	ENST00000414097.2	-	4	1069	c.202A>G	c.(202-204)Aac>Gac	p.N68D	NDRG1_ENST00000518066.1_Intron|NDRG1_ENST00000518176.1_Intron|NDRG1_ENST00000522476.1_Missense_Mutation_p.N2D|NDRG1_ENST00000323851.7_Missense_Mutation_p.N68D|NDRG1_ENST00000537882.1_Intron|NDRG1_ENST00000354944.5_Missense_Mutation_p.N68D	NM_001135242.1	NP_001128714.1	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	68					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding		NDRG1/ERG(5)	endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(4)|prostate(1)|skin(1)	17	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			AACTTACGGTTCATGCCGATG	0.572000			T	ERG	prostate								16	30					0	0	1	0	0
ANAPC1	64682	broad.mit.edu	37	2	112545823	112545823	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:112545823C>A	ENST00000341068.3	-	39	5559	c.4787G>T	c.(4786-4788)aGc>aTc	p.S1596I		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	1596					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						GTTGTCAGTGCTGTGAGCTGG	0.433000													4	17					2.7689e-08	2.91998e-08	1	1	0
KRT3	3850	broad.mit.edu	37	12	53187986	53187986	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53187986G>A	ENST00000417996.2	-	2	849	c.775C>T	c.(775-777)Cgg>Tgg	p.R259W	KRT3_ENST00000309505.3_Missense_Mutation_p.R259W	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	259	Coil 1B.|Rod.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						AGGTAGCTCCGCAGGTAGTTG	0.537000													27	98					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38165309	38165309	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38165309G>A	ENST00000406386.3	+	21	7031	c.6776G>A	c.(6775-6777)cGc>cAc	p.R2259H	TRIOBP_ENST00000403663.2_Missense_Mutation_p.R546H|RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	2259					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GACCAGCTGCGCGGCTTCATT	0.667000													7	8					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	466873	466873	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:466873C>T	ENST00000512944.1	+	13	2287	c.2098C>T	c.(2098-2100)Cgt>Tgt	p.R700C	EXOC3_ENST00000315013.5_Missense_Mutation_p.R700C|CTD-2228K2.5_ENST00000510714.1_Intron	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	711					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GCTGGCTGTGCGTGGGGACGC	0.642000													6	12					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43932934	43932934	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:43932934C>T	ENST00000537548.1	-	4	821	c.577G>A	c.(577-579)Gtc>Atc	p.V193I	MATN4_ENST00000353917.5_Missense_Mutation_p.V193I|MATN4_ENST00000372753.1_Intron|MATN4_ENST00000342716.4_Missense_Mutation_p.V193I|MATN4_ENST00000372754.1_Missense_Mutation_p.V193I|MATN4_ENST00000360607.5_Missense_Mutation_p.V193I|MATN4_ENST00000372756.1_Missense_Mutation_p.V193I|MATN4_ENST00000372751.4_Intron			O95460	MATN4_HUMAN	matrilin 4	193	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				ACGAGGAAGACGTGCTCGTCT	0.657000													12	21					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42460072	42460072	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:42460072G>A	ENST00000379310.3	-	8	1027	c.959C>T	c.(958-960)gCt>gTt	p.A320V	VWA8_ENST00000281496.6_Missense_Mutation_p.A320V	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		TTGAACCGCAGCTGCTAAACT	0.358000													14	23					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188283	57188283	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:57188283C>T	ENST00000331162.4	-	5	1109	c.839G>A	c.(838-840)cGc>cAc	p.R280H		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	280					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TGCTGAGGAGCGCCTAAAGGC	0.463000													24	32					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139323133	139323133	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:139323133C>T	ENST00000395297.1	-	3	278	c.108G>A	c.(106-108)gtG>gtA	p.V36V		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	36										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCCTTGAAGACACCTTCAAGG	0.507000										HNSCC(54;0.14)			29	53					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110819782	110819782	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:110819782G>T	ENST00000282356.4	+	11	1438	c.1040G>T	c.(1039-1041)gGc>gTc	p.G347V	CAMK4_ENST00000512453.1_Missense_Mutation_p.G347V|CAMK4_ENST00000512890.1_3'UTR	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	347					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		AGCAGCCATGGCAGCATCCAG	0.537000													13	22					4.3838e-07	4.58243e-07	1	1	0
PILRA	29992	broad.mit.edu	37	7	99971888	99971888	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99971888C>T	ENST00000198536.2	+	2	498	c.286C>T	c.(286-288)Cgg>Tgg	p.R96W	PILRA_ENST00000394000.2_Missense_Mutation_p.R96W|PILRA_ENST00000453419.1_Missense_Mutation_p.R96W|PILRA_ENST00000474013.1_3'UTR|PILRA_ENST00000350573.2_Missense_Mutation_p.R96W	NM_013439.2	NP_038467.2	Q9UKJ1	PILRA_HUMAN	paired immunoglobin-like type 2 receptor alpha	96	Ig-like V-type.				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	15	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTATGTGAACCGGCTCTTTCT	0.547000													31	72					0	0	1	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30691820	30691820	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:30691820A>G	ENST00000215790.7	-	4	594	c.430T>C	c.(430-432)Tcc>Ccc	p.S144P	RP1-130H16.18_ENST00000447976.1_Missense_Mutation_p.S18P|TBC1D10A_ENST00000403362.1_Missense_Mutation_p.S56P|TBC1D10A_ENST00000403477.3_Missense_Mutation_p.S151P	NM_031937.2	NP_114143.1	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	144	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						TCCCCAGGGGACATGTCCAGC	0.627000													5	6					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46660982	46660982	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:46660982C>A	ENST00000544460.1	+	1	5371	c.5117C>A	c.(5116-5118)gCt>gAt	p.A1706D	TDRD6_ENST00000316081.6_Missense_Mutation_p.A1706D	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1706					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			ATTAAAAGTGCTCTTCCCTAT	0.318000													17	51					1.99824e-07	2.09433e-07	1	1	0
PYCRL	65263	broad.mit.edu	37	8	144687917	144687917	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144687917C>T	ENST00000220966.6	-	6	843	c.814G>A	c.(814-816)Gcc>Acc	p.A272T	PYCRL_ENST00000377579.3_Missense_Mutation_p.A123T|PYCRL_ENST00000495276.1_5'UTR	NM_023078.3	NP_075566.2	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	260					proline biosynthetic process		pyrroline-5-carboxylate reductase activity			central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)	5	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GCCTCCACGGCGCTCATGGTG	0.682000													7	13					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39974444	39974444	+	Silent	SNP	C	C	T	rs139989453		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39974444C>T	ENST00000321562.4	+	3	599	c.495C>T	c.(493-495)ccC>ccT	p.P165P		NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	165					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		TGCGCCCGCCCCACTGCCCCC	0.622000													19	24					0	0	1	0	0
FAM83F	113828	broad.mit.edu	37	22	40417440	40417440	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:40417440G>T	ENST00000333407.5	+	4	1020	c.926G>T	c.(925-927)aGg>aTg	p.R309M	FAM83F_ENST00000473717.1_3'UTR	NM_138435.2	NP_612444.2	Q8NEG4	FA83F_HUMAN	family with sequence similarity 83, member F	309										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|skin(4)|urinary_tract(2)	14						CTGGCGGGCAGGGTTGGCCTC	0.617000													5	82					0.184627	0.185007	1	1	0
RHBG	57127	broad.mit.edu	37	1	156348053	156348053	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156348053C>T	ENST00000400992.2	+	4	808	c.440C>T	c.(439-441)gCc>gTc	p.A147V	RHBG_ENST00000255013.3_Missense_Mutation_p.A110V|RHBG_ENST00000451864.2_Missense_Mutation_p.A147V|RHBG_ENST00000368246.2_Missense_Mutation_p.A179V|RHBG_ENST00000368249.1_Missense_Mutation_p.A179V|RHBG_ENST00000537040.1_Intron			Q9H310	RHBG_HUMAN	Rh family, B glycoprotein (gene/pseudogene)	179					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					GTGAGAGATGCCGGAGGCTCC	0.662000													23	42					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111387340	111387340	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:111387340C>T	ENST00000428084.1	-	43	4848	c.4576G>A	c.(4576-4578)Gtt>Att	p.V1526I	DOCK4_ENST00000437633.1_Missense_Mutation_p.V1517I|DOCK4_ENST00000494651.2_Missense_Mutation_p.V400I			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1517	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TACCTGGAAACGCCACCATTA	0.383000													7	14					0	0	1	0	0
CCHCR1	54535	broad.mit.edu	37	6	31112527	31112527	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31112527G>A	ENST00000396268.3	-	15	2292	c.2104C>T	c.(2104-2106)Cgg>Tgg	p.R702W	CCHCR1_ENST00000376266.5_Missense_Mutation_p.R613W|CCHCR1_ENST00000451521.2_Missense_Mutation_p.R666W|CCHCR1_ENST00000396263.2_Missense_Mutation_p.R560W	NM_001105563.1|NM_001105564.1	NP_001099033.1|NP_001099034.1	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1	613					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						AGTTGCTCCCGCAGCCGAGTT	0.602000													70	93					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890687	229890687	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:229890687G>A	ENST00000392054.3	-	4	747	c.408C>T	c.(406-408)atC>atT	p.I136I	PID1_ENST00000409462.1_Silent_p.I56I|PID1_ENST00000392055.3_Silent_p.I105I|PID1_ENST00000482518.2_Intron|PID1_ENST00000354069.6_Silent_p.I138I	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	138	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GGAATGGCCGGATTTCCAGGA	0.567000													13	21					0	0	1	0	0
TREX2	11219	broad.mit.edu	37	X	152713217	152713217	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:152713217C>T	ENST00000414588.1	-	1	104	c.35G>A	c.(34-36)cGt>cAt	p.R12H	TREX2_ENST00000338525.2_5'UTR|TREX2_ENST00000334497.2_Silent_p.T28T|TREX2_ENST00000370232.1_Silent_p.T28T|TREX2_ENST00000402951.1_Silent_p.T28T|HAUS7_ENST00000370219.3_3'UTR|HAUS7_ENST00000484394.1_5'UTR|HAUS7_ENST00000421080.2_3'UTR|TREX2_ENST00000393862.2_5'UTR|HAUS7_ENST00000370211.4_3'UTR|TREX2_ENST00000330912.2_5'UTR			Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	0					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(2)	11	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TAGAGCACAACGTGGGGCTGC	0.587000								Editing and processing nucleases					76	13					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56274580	56274580	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:56274580C>A	ENST00000361673.3	-	3	414	c.201G>T	c.(199-201)caG>caT	p.Q67H		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	67	Ig-like 1.						ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CATGAATATACTGATTCTCAA	0.398000													39	59					2.40579e-17	2.64746e-17	1	1	0
ZNF598	90850	broad.mit.edu	37	16	2048469	2048469	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2048469G>A	ENST00000563630.1	-	12	2556	c.2314C>T	c.(2314-2316)Ctc>Ttc	p.L772F	ZNF598_ENST00000431526.1_Missense_Mutation_p.L827F|ZNF598_ENST00000562103.1_Missense_Mutation_p.L772F			Q86UK7	ZN598_HUMAN	zinc finger protein 598	827						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						GCAGACAGGAGCTCCTGCTGC	0.587000													25	32					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43749072	43749072	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43749072C>A	ENST00000263801.3	-	12	1971	c.1719G>T	c.(1717-1719)caG>caT	p.Q573H	TP53BP1_ENST00000450115.2_Missense_Mutation_p.Q578H|TP53BP1_ENST00000382039.3_Missense_Mutation_p.Q578H|TP53BP1_ENST00000382044.4_Missense_Mutation_p.Q578H	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	573					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CTTCACCATCCTGTGCTGGAT	0.418000								Other conserved DNA damage response genes					33	54					1.61788e-16	1.77753e-16	1	1	0
BTBD2	55643	broad.mit.edu	37	19	1987589	1987589	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1987589C>T	ENST00000255608.4	-	6	1107	c.1091G>A	c.(1090-1092)cGc>cAc	p.R364H		NM_017797.3	NP_060267.2	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	364						cytoplasmic mRNA processing body	protein binding			endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)	12		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGCAGCAGCGGGGCCGGTC	0.652000													4	14					0	0	1	0	0
KCTD18	130535	broad.mit.edu	37	2	201369584	201369584	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:201369584C>T	ENST00000359878.3	-	3	769	c.259G>A	c.(259-261)Gcc>Acc	p.A87T	KCTD18_ENST00000468413.1_5'UTR|KCTD18_ENST00000409157.1_Missense_Mutation_p.A87T	NM_152387.2	NP_689600.2	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain containing 18	87						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.A87T(1)		endometrium(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						TCCTGTAGGGCGATGCGGGTT	0.433000													27	29					0	0	1	0	0
PODXL2	50512	broad.mit.edu	37	3	127388016	127388016	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:127388016C>T	ENST00000342480.6	+	6	1435	c.1396C>T	c.(1396-1398)Ctg>Ttg	p.L466L		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	466					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						CCTTTCCATGCTGGGTGACAT	0.572000													4	10					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359023	66359023	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66359023G>A	ENST00000333861.3	-	1	1531	c.1464C>T	c.(1462-1464)ggC>ggT	p.G488G		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	488										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						TGGTAGTACTGCCAACAAAGT	0.473000													55	93					0	0	1	0	0
CARD14	79092	broad.mit.edu	37	17	78156559	78156559	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78156559C>T	ENST00000573882.1	+	5	855	c.319C>T	c.(319-321)Cag>Tag	p.Q107*	CARD14_ENST00000344227.2_Nonsense_Mutation_p.Q107*|CARD14_ENST00000570421.1_Nonsense_Mutation_p.Q107*			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	107	CARD.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CACCGGGCTGCAGCCTGATGT	0.572000													17	30					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62291032	62291032	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62291032G>A	ENST00000378024.4	-	5	11131	c.10857C>T	c.(10855-10857)ggC>ggT	p.G3619G	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3619					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CGACTTCAGGGCCTTCTCCTT	0.478000													46	235					0	0	1	0	0
DCAF11	0	broad.mit.edu	37	14	24589002	24589002	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24589002C>T	ENST00000446197.3	+	11	1716	c.989C>T	c.(988-990)gCc>gTc	p.A330V	DCAF11_ENST00000396941.4_Missense_Mutation_p.A304V|DCAF11_ENST00000559115.1_Missense_Mutation_p.A330V|DCAF11_ENST00000396936.1_Missense_Mutation_p.A230V	NM_025230.4	NP_079506.3	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11	330						CUL4 RING ubiquitin ligase complex	protein binding										GGAGATGATGCCATCTGCAAA	0.547000													10	18					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126371285	126371285	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126371285G>A	ENST00000394329.3	+	9	9127	c.9114G>A	c.(9112-9114)acG>acA	p.T3038T	FAT4_ENST00000335110.5_Silent_p.T1336T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3038	Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.T3038T(2)		NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ACAATGATACGGGGTGGATTT	0.373000													20	25					0	0	1	0	0
PARPBP	55010	broad.mit.edu	37	12	102572527	102572527	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:102572527C>T	ENST00000327680.2	+	9	1383	c.920C>T	c.(919-921)aCg>aTg	p.T307M	PARPBP_ENST00000543784.1_Intron|PARPBP_ENST00000535811.1_Intron|PARPBP_ENST00000541394.1_Missense_Mutation_p.T465M|PARPBP_ENST00000392911.2_Missense_Mutation_p.T307M|PARPBP_ENST00000358383.5_Missense_Mutation_p.T388M|PARPBP_ENST00000378128.3_Intron	NM_017915.3	NP_060385.3	Q9NWS1	PR1BP_HUMAN	PARP1 binding protein	388					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding			endometrium(1)|lung(8)|urinary_tract(2)	11						CATCATGGAACGTCTATTCTT	0.328000													17	33					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45941817	45941817	+	Silent	SNP	C	C	T	rs150444121	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:45941817C>T	ENST00000323084.4	-	9	1580	c.1515G>A	c.(1513-1515)tcG>tcA	p.S505S	C21orf90_ENST00000465978.1_Intron|TSPEAR_ENST00000397916.1_Silent_p.S437S	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	505					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						TGTAGAGGTGCGAGTGCACCT	0.642000													23	7					0	0	1	0	0
CTPS1	1503	broad.mit.edu	37	1	41466749	41466749	+	Missense_Mutation	SNP	G	G	A	rs150289603		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:41466749G>A	ENST00000372621.4	+	10	1562	c.1054G>A	c.(1054-1056)Gtg>Atg	p.V352M	CTPS1_ENST00000541520.1_Missense_Mutation_p.V121M|CTPS1_ENST00000372616.1_Missense_Mutation_p.V352M	NM_001905.2	NP_001896.2	P17812	PYRG1_HUMAN	CTP synthase 1	352	Glutamine amidotransferase type-1.				CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding			endometrium(3)|lung(10)	13					L-Glutamine(DB00130)	AGAAGAGCCCGTGCGCTACCA	0.507000													13	19					0	0	1	0	0
B3GALNT2	148789	broad.mit.edu	37	1	235622019	235622019	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:235622019T>C	ENST00000366600.3	-	8	1145	c.917A>G	c.(916-918)gAa>gGa	p.E306G		NM_152490.2	NP_689703.1	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	306					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			TAAGGCATCTTCCTCATGGAG	0.383000													8	58					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126355544	126355544	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126355544C>T	ENST00000394329.3	+	7	7176	c.7163C>T	c.(7162-7164)gCc>gTc	p.A2388V	FAT4_ENST00000335110.5_Missense_Mutation_p.A686V	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2388	Cadherin 23.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TTGGTAAATGCCTCAGATGCT	0.363000													35	40					0	0	1	0	0
PNCK	139728	broad.mit.edu	37	X	152936838	152936838	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:152936838C>T	ENST00000393831.2	-	7	1019	c.585G>A	c.(583-585)gcG>gcA	p.A195A	PNCK_ENST00000370145.4_Intron|PNCK_ENST00000370150.1_Intron|PNCK_ENST00000447676.2_Intron|PNCK_ENST00000370142.1_Silent_p.A195A|PNCK_ENST00000340888.3_Intron	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	179	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GACAGACAGACGCACGCACAG	0.622000													17	4					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100210199	100210199	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:100210199G>A	ENST00000317233.4	-	14	2159	c.1924C>T	c.(1924-1926)Cgc>Tgc	p.R642C	AFF3_ENST00000409579.1_Missense_Mutation_p.R667C|AFF3_ENST00000356421.2_Missense_Mutation_p.R667C|AFF3_ENST00000409236.1_Missense_Mutation_p.R642C	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	642					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.R667C(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						ACGGAGGAGCGCAGCTCCTTG	0.657000													12	28					0	0	1	0	0
NIP7	51388	broad.mit.edu	37	16	69375508	69375508	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:69375508C>T	ENST00000254940.5	+	5	896	c.496C>T	c.(496-498)Caa>Taa	p.Q166*	RP11-343C2.7_ENST00000564737.1_Intron|NIP7_ENST00000254941.6_Nonsense_Mutation_p.Q119*|RP11-343C2.9_ENST00000563634.1_Intron	NM_016101.4	NP_057185.1	Q9Y221	NIP7_HUMAN	NIP7, nucleolar pre-rRNA processing protein	166	PUA.				ribosome assembly	nucleolus	protein binding|RNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)	6		Ovarian(137;0.101)				GGTATTTCATCAAGCAGACAT	0.468000													43	54					0	0	1	0	0
GABRA5	2558	broad.mit.edu	37	15	27188527	27188527	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:27188527G>A	ENST00000335625.5	+	10	1931	c.1043G>A	c.(1042-1044)gGc>gAc	p.G348D	GABRA5_ENST00000355395.5_Missense_Mutation_p.G348D|GABRA5_ENST00000400081.3_Missense_Mutation_p.G348D	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	348					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity	p.G348D(1)		NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACCAAGAGAGGCTGGGCCTGG	0.527000													6	6					0	0	1	0	0
ATRN	8455	broad.mit.edu	37	20	3520965	3520965	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:3520965G>A	ENST00000262919.5	+	3	659	c.591G>A	c.(589-591)ccG>ccA	p.P197P	ATRN_ENST00000446916.2_Silent_p.P197P	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	197	CUB.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						TTTATGCACCGCTAGTTGCTG	0.368000													49	78					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174623	51174623	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:51174623G>A	ENST00000440970.1	-	2	1650	c.1219C>T	c.(1219-1221)Cct>Tct	p.P407S	SALL1_ENST00000251020.4_Missense_Mutation_p.P504S|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	504					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGATATGAGGGTATTTCTCT	0.517000													35	45					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43012606	43012606	+	Missense_Mutation	SNP	C	C	T	rs147975805		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43012606C>T	ENST00000535468.1	-	16	3394	c.3308G>A	c.(3307-3309)cGc>cAc	p.R1103H	CUL7_ENST00000265348.3_Missense_Mutation_p.R1019H	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	1019					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CTGCTCCTGGCGCAGAGCACC	0.597000													29	34					0	0	1	0	0
C16orf59	80178	broad.mit.edu	37	16	2510927	2510927	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2510927G>A	ENST00000569496.1	+	4	366	c.307G>A	c.(307-309)Gcc>Acc	p.A103T	C16orf59_ENST00000483320.1_5'UTR|C16orf59_ENST00000563531.1_Missense_Mutation_p.A103T|C16orf59_ENST00000361837.4_Missense_Mutation_p.A103T			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	103										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				GAGAGACAAGGCCCCCAGCCT	0.577000													12	28					0	0	1	0	0
PEBP4	157310	broad.mit.edu	37	8	22584731	22584731	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22584731G>A	ENST00000256404.6	-	5	451	c.360C>T	c.(358-360)ggC>ggT	p.G120G	RP11-459E5.1_ENST00000523627.1_RNA	NM_144962.2	NP_659399.2	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	120						lysosome		p.G120G(1)		breast(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|stomach(2)	10		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		TCAGGTCGGCGCCCTGAAAGA	0.572000													10	6					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26691066	26691066	+	Missense_Mutation	SNP	C	C	T	rs142754209		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26691066C>T	ENST00000436292.1	-	4	1091	c.971G>A	c.(970-972)tGc>tAc	p.C324Y	ZNF683_ENST00000374204.1_Missense_Mutation_p.C324Y|ZNF683_ENST00000349618.3_Missense_Mutation_p.C324Y|ZNF683_ENST00000403843.1_Missense_Mutation_p.C324Y			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		ACATATGTTGCACTCGTACAG	0.547000													69	112					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189906341	189906341	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:189906341G>A	ENST00000374866.3	-	50	3878	c.3604C>T	c.(3604-3606)Cga>Tga	p.R1202*		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1202					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			ACACTGCCTCGTACACCTGGA	0.483000													15	71					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228466411	228466411	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228466411G>A	ENST00000570156.2	+	31	8242	c.8168G>A	c.(8167-8169)cGc>cAc	p.R2723H	OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000359599.6_Missense_Mutation_p.R1141H|OBSCN_ENST00000422127.1_Missense_Mutation_p.R2294H|OBSCN_ENST00000284548.11_Missense_Mutation_p.R2294H	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1721	Ig-like 26.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ACCCTCGTGCGCCCGCTGCGG	0.662000													7	21					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152079962	152079962	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:152079962G>A	ENST00000368804.1	-	2	5730	c.5731C>T	c.(5731-5733)Cgg>Tgg	p.R1911W		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1911					keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCAGAAGCCGCCCATGGCCC	0.562000													28	38					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55562659	55562659	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55562659C>T	ENST00000294383.6	-	49	5901	c.5902G>A	c.(5902-5904)Gca>Aca	p.A1968T	USP24_ENST00000407756.1_Missense_Mutation_p.A1808T	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1968					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						TAGTGGCCTGCGTGTGCCTGC	0.517000													3	30					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47629421	47629421	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:47629421A>G	ENST00000546455.1	+	4	1306	c.575A>G	c.(574-576)gAa>gGa	p.E192G	PCED1B_ENST00000432328.1_Missense_Mutation_p.E192G					PC-esterase domain containing 1B																		CTGAAAAACGAAGTGGTCAAA	0.582000													10	12					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730747	57730747	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:57730747A>G	ENST00000281282.5	+	2	628	c.550A>G	c.(550-552)Aac>Gac	p.N184D		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	184	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGAAGGCATCAACAATAAGAA	0.453000													69	72					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108489163	108489163	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:108489163C>T	ENST00000408999.3	+	20	4780	c.4703C>T	c.(4702-4704)tCt>tTt	p.S1568F	RGPD4_ENST00000354986.4_Missense_Mutation_p.S1568F	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1568					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						GCCACTGGGTCTTTGTTTGGA	0.353000													74	130					0	0	1	0	0
KBTBD4	55709	broad.mit.edu	37	11	47599542	47599542	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:47599542G>A	ENST00000533290.1	-	1	799	c.85C>T	c.(85-87)Cca>Tca	p.P29S	NDUFS3_ENST00000533507.1_Intron|KBTBD4_ENST00000526005.1_Missense_Mutation_p.P4S|KBTBD4_ENST00000450908.1_3'UTR|KBTBD4_ENST00000395288.2_Missense_Mutation_p.P4S|KBTBD4_ENST00000430070.2_Missense_Mutation_p.P20S|KBTBD4_ENST00000525720.1_Missense_Mutation_p.P53S			Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	4										NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	24						GGCTCCTCTGGTGATTCCATG	0.478000													23	27					0	0	1	0	0
ZACN	353174	broad.mit.edu	37	17	74077646	74077646	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74077646G>A	ENST00000334586.5	+	7	773	c.690G>A	c.(688-690)gcG>gcA	p.A230A	EXOC7_ENST00000332065.5_3'UTR|EXOC7_ENST00000591724.1_Intron|EXOC7_ENST00000607838.1_3'UTR|EXOC7_ENST00000589210.1_3'UTR	NM_180990.3	NP_851321.2	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	230	Leu-rich.				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	11						AGAACACGGCGCTCAAGTCCA	0.667000													43	70					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187858	152187858	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:152187858G>A	ENST00000368801.2	-	3	6322	c.6247C>T	c.(6247-6249)Cga>Tga	p.R2083*	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2083					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCCATGTCGGCCATAGCTG	0.622000													33	73					0	0	1	0	0
EPN2	22905	broad.mit.edu	37	17	19232167	19232167	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:19232167G>A	ENST00000314728.5	+	8	1775	c.1291G>A	c.(1291-1293)Gca>Aca	p.A431T	EPN2_ENST00000395620.2_Missense_Mutation_p.A374T|EPN2_ENST00000571254.1_Missense_Mutation_p.A367T|EPN2_ENST00000395626.1_Missense_Mutation_p.A431T|EPN2_ENST00000395618.3_Missense_Mutation_p.A146T|EPN2_ENST00000347697.2_Missense_Mutation_p.A374T|EPN2_ENST00000575595.1_Missense_Mutation_p.A139T	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	431	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CGCGTGGGGCGCAGTCTCCAC	0.647000													29	33					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126734114	126734114	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:126734114G>T	ENST00000251772.4	+	14	2965	c.2896G>T	c.(2896-2898)Ggc>Tgc	p.G966C	PLXNA1_ENST00000393409.2_Missense_Mutation_p.G989C			Q9UIW2	PLXA1_HUMAN	plexin A1	989	IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CCTGAACGCAGGCAGTGATGT	0.662000													16	14					6.94344e-10	7.39541e-10	1	1	0
ZDHHC8	29801	broad.mit.edu	37	22	20128155	20128155	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:20128155C>T	ENST00000334554.7	+	6	817	c.676C>T	c.(676-678)Cgc>Tgc	p.R226C	ZDHHC8_ENST00000468112.1_3'UTR|ZDHHC8_ENST00000320602.7_Missense_Mutation_p.R134C|ZDHHC8_ENST00000405930.3_Missense_Mutation_p.R226C	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	226						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					TGGGAAGTTCCGCGGGGGTGT	0.697000													3	3					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058218	11058218	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:11058218C>A	ENST00000470054.1	-	0	429									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGACTGAAATCCTGAAAGGTG	0.413000													22	65					5.35356e-11	5.74024e-11	1	1	0
MDFI	4188	broad.mit.edu	37	6	41617506	41617506	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:41617506G>A	ENST00000373050.4	+	3	413	c.226G>A	c.(226-228)Gcc>Acc	p.A76T				Q99750	MDFI_HUMAN	MyoD family inhibitor	137					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|prostate(2)|skin(1)|urinary_tract(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			CCCATCTCTCGCCAGCCAGGG	0.642000													26	37					0	0	1	0	0
FAM83G	644815	broad.mit.edu	37	17	18882884	18882884	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18882884G>A	ENST00000388995.6	-	4	1016	c.793C>T	c.(793-795)Cgg>Tgg	p.R265W	SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000417251.2_Intron|FAM83G_ENST00000345041.4_Missense_Mutation_p.R265W|SLC5A10_ENST00000395642.1_Intron|SLC5A10_ENST00000317977.6_Intron|SLC5A10_ENST00000395643.2_Intron|SLC5A10_ENST00000395647.2_Intron|FAM83G_ENST00000585154.2_Missense_Mutation_p.R265W			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	265										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						CACACAGCCCGGTCTCCATCC	0.582000													12	15					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75892921	75892921	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:75892921G>A	ENST00000322507.8	-	10	2045	c.1736C>T	c.(1735-1737)gCc>gTc	p.A579V	COL12A1_ENST00000483888.2_Missense_Mutation_p.A579V|COL12A1_ENST00000416123.2_Missense_Mutation_p.A579V|COL12A1_ENST00000345356.6_Intron	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	579	VWFA 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TGAGCGAACGGCATCCTTCAC	0.428000													24	26					0	0	1	0	0
CXCR2P1	0	broad.mit.edu	37	2	218925608	218925608	+	RNA	SNP	C	C	T	rs114651961	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:218925608C>T	ENST00000439871.1	-	0	772					NR_002712.1																						AAGCAAGATGCGTAGGGACAG	0.517000													10	14					0	0	1	0	0
PNMAL2	57469	broad.mit.edu	37	19	46997592	46997592	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46997592G>A	ENST00000599531.1	-	1	2163	c.1131C>T	c.(1129-1131)tcC>tcT	p.S377S	PNMAL2_ENST00000594749.1_Intron|PNMAL2_ENST00000377655.2_Intron	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	377										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		TGGACATGACGGACAAGACCT	0.642000													15	26					0	0	1	0	0
KCNH8	131096	broad.mit.edu	37	3	19575323	19575323	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:19575323C>T	ENST00000328405.2	+	16	3322	c.3056C>T	c.(3055-3057)aCg>aTg	p.T1019M		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	1019	Ser-rich.					integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						TCAGATTCTACGTTGACGCCT	0.453000													69	101					0	0	1	0	0
S1PR2	9294	broad.mit.edu	37	19	10334881	10334881	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10334881G>A	ENST00000590320.1	-	2	811	c.701C>T	c.(700-702)aCg>aTg	p.T234M		NM_004230.3	NP_004221.3	O95136	S1PR2_HUMAN	sphingosine-1-phosphate receptor 2	234					activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						GATGGTGACCGTCTTGAGCAG	0.627000													3	14					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256021	15256021	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:15256021C>T	ENST00000378116.4	-	8	1572	c.1566G>A	c.(1564-1566)gcG>gcA	p.A522A		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	522						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GTGATGAAGGCGCGGGGTACA	0.527000													45	103					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	24048792	24048792	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:24048792G>A	ENST00000546136.1	-	1	168	c.166C>T	c.(166-168)Cca>Tca	p.P56S	SOX5_ENST00000545921.1_Missense_Mutation_p.P59S|SOX5_ENST00000381381.2_Missense_Mutation_p.P56S|SOX5_ENST00000451604.2_Missense_Mutation_p.P69S|SOX5_ENST00000541847.1_Missense_Mutation_p.P59S|SOX5_ENST00000541536.1_Missense_Mutation_p.P56S|SOX5_ENST00000441133.2_Intron|SOX5_ENST00000537393.1_Intron|SOX5_ENST00000309359.1_Missense_Mutation_p.P56S			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	69					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						AGAGAAACTGGCTGAAATTCC	0.493000													80	99					0	0	1	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97933678	97933678	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:97933678C>T	ENST00000005260.8	-	12	1467	c.1252G>A	c.(1252-1254)Gtg>Atg	p.V418M		NM_018842.4	NP_061330.2	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	418					filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)	23	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			ATGCTTCTCACTGGTGTGGGG	0.527000													12	13					0	0	1	0	0
LY6H	4062	broad.mit.edu	37	8	144239899	144239899	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144239899C>A	ENST00000414417.2	-	5	487	c.254G>T	c.(253-255)aGg>aTg	p.R85M	LY6H_ENST00000342752.4_Missense_Mutation_p.R85M|LY6H_ENST00000430474.2_Missense_Mutation_p.R64M	NM_001130478.1	NP_001123950.1	O94772	LY6H_HUMAN	lymphocyte antigen 6 complex, locus H	64	UPAR/Ly6.				nervous system development|organ morphogenesis	anchored to membrane|plasma membrane				endometrium(1)|lung(1)|stomach(2)	4	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GTGATCCTTCCTGCCTGGGAA	0.592000													3	28					0.115264	0.115739	1	1	0
CBX4	8535	broad.mit.edu	37	17	77809045	77809045	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:77809045C>T	ENST00000269397.4	-	5	573	c.396G>A	c.(394-396)ccG>ccA	p.P132P	CBX4_ENST00000448310.1_3'UTR	NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	132	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CCTTGCTGTGCGGCTGGTACT	0.647000											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	52					0	0	1	0	0
ENKD1	84080	broad.mit.edu	37	16	67697373	67697373	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67697373G>A	ENST00000243878.4	-	6	1151	c.830C>T	c.(829-831)aCg>aTg	p.T277M	ENKD1_ENST00000602644.1_Silent_p.H222H	NM_032140.1	NP_115516.1			enkurin domain containing 1																		AGGCATGCGCGTGTGGCCTGG	0.697000													22	40					0	0	1	0	0
OGDH	4967	broad.mit.edu	37	7	44733588	44733588	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44733588C>T	ENST00000222673.5	+	11	1542	c.1500C>T	c.(1498-1500)gaC>gaT	p.D500D	OGDH_ENST00000439616.2_Silent_p.D350D|OGDH_ENST00000444676.1_Silent_p.D515D|OGDH_ENST00000447398.1_Silent_p.D511D|OGDH_ENST00000543843.1_Silent_p.D451D|OGDH_ENST00000449767.1_Silent_p.D496D	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	500					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	TCCACAAGGACGTGGTTGTCG	0.597000													6	7					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169227857	169227857	+	Silent	SNP	C	C	T	rs140161501		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:169227857C>T	ENST00000393743.3	-	5	570	c.279G>A	c.(277-279)gcG>gcA	p.A93A		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	93							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AGTTGAAATACGCATACTCGG	0.363000													27	31					0	0	1	0	0
LNP1	348801	broad.mit.edu	37	3	100170610	100170610	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:100170610G>A	ENST00000383693.3	+	3	1484	c.204G>A	c.(202-204)agG>agA	p.R68R	LNP1_ENST00000489752.1_Silent_p.R81R	NM_001085451.1	NP_001078920.1	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	68										cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6						ATCCTAGAAGGCATTCTCATG	0.428000													4	35					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7774729	7774729	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:7774729G>A	ENST00000420658.1	-	16	2343	c.2071C>T	c.(2071-2073)Ccg>Tcg	p.P691S	AFAP1_ENST00000513842.1_5'UTR|AFAP1_ENST00000382543.3_Missense_Mutation_p.P691S|AFAP1_ENST00000358461.2_Missense_Mutation_p.P607S|AFAP1_ENST00000360265.4_Missense_Mutation_p.P607S	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	628						actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						ATCGCCTGCGGCTTCCTGCCT	0.607000													11	6					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	17949514	17949514	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:17949514G>T	ENST00000361221.3	+	12	1203	c.1044G>T	c.(1042-1044)gaG>gaT	p.E348D	ARHGEF10L_ENST00000375408.3_Missense_Mutation_p.E126D|ARHGEF10L_ENST00000452522.1_Missense_Mutation_p.E309D|ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000375420.3_Missense_Mutation_p.E106D|ARHGEF10L_ENST00000375415.1_Missense_Mutation_p.E309D|ARHGEF10L_ENST00000167825.4_Missense_Mutation_p.E126D|ARHGEF10L_ENST00000434513.1_Missense_Mutation_p.E348D	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	348	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CCCTGATGGAGATGGAGCCCA	0.667000													9	14					3.86212e-05	3.97146e-05	1	1	0
MYH9	4627	broad.mit.edu	37	22	36710262	36710262	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36710262G>A	ENST00000216181.5	-	13	1712	c.1482C>T	c.(1480-1482)cgC>cgT	p.R494R		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	494	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CGATGCCCTCGCGCTGGTACT	0.537000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				30	35					0	0	1	0	0
ENTPD1	953	broad.mit.edu	37	10	97625945	97625945	+	Silent	SNP	C	C	T	rs139646807	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:97625945C>T	ENST00000371203.5	+	9	1511	c.924C>T	c.(922-924)agC>agT	p.S308S	RP11-248J23.7_ENST00000491114.1_Intron|ENTPD1_ENST00000371207.3_Silent_p.S458S|ENTPD1_ENST00000453258.2_Silent_p.S453S|ENTPD1_ENST00000371205.4_Silent_p.S446S|ENTPD1_ENST00000539125.1_Silent_p.S308S|ENTPD1_ENST00000543964.1_Silent_p.S338S|RP11-429G19.3_ENST00000433113.1_RNA|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1-AS1_ENST00000451364.1_RNA	NM_001164179.1|NM_001164182.1|NM_001776.5	NP_001157651.1|NP_001157654.1|NP_001767.3	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	446					cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		TCCAGGGCAGCGACGCCGGCT	0.507000													8	8					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124766120	124766120	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:124766120C>A	ENST00000306534.3	-	4	1138	c.653G>T	c.(652-654)aGc>aTc	p.S218I	ROBO4_ENST00000526899.1_5'UTR|ROBO4_ENST00000533054.1_Missense_Mutation_p.S73I	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	218	Ig-like C2-type 2.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GGCTGCGCGGCTCTCCCTATG	0.612000													20	33					5.35267e-07	5.59292e-07	1	1	0
ACRC	93953	broad.mit.edu	37	X	70817888	70817888	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:70817888G>A	ENST00000373695.1	+	6	847	c.310_splice	c.e6+1	p.D104_splice	ACRC_ENST00000373696.3_Splice_Site_p.D104_splice			Q96QF7	ACRC_HUMAN	acidic repeat containing	104						nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					AAACAGCGACGGCAAGTATAT	0.418000													15	5					0	0	1	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17363216	17363216	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:17363216C>T	ENST00000377602.4	-	8	932	c.858G>A	c.(856-858)acG>acA	p.T286T		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	286					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						ACTCTTCGAGCGTGTAGTATA	0.433000													49	73					0	0	1	0	0
TLK1	9874	broad.mit.edu	37	2	171863309	171863309	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:171863309C>T	ENST00000442919.2	-	16	2070		c.e16+1		TLK1_ENST00000360843.3_Splice_Site|TLK1_ENST00000521943.1_Splice_Site|TLK1_ENST00000434911.2_Splice_Site|TLK1_ENST00000431350.2_Splice_Site	NM_012290.4	NP_036422.3	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1						cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|liver(3)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TATTCACTTACGTATCTGTAT	0.363000													10	81					0	0	1	0	0
ZFR	51663	broad.mit.edu	37	5	32390446	32390446	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:32390446G>A	ENST00000265069.8	-	12	2179	c.2077C>T	c.(2077-2079)Cct>Tct	p.P693S		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	693					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		GGGCCTGGAGGACCATGAGGA	0.552000													23	31					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83838913	83838913	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:83838913G>A	ENST00000349129.2	+	16	2287	c.2027G>A	c.(2026-2028)tGc>tAc	p.C676Y	DOPEY1_ENST00000237163.5_Missense_Mutation_p.C657Y|DOPEY1_ENST00000369739.3_Missense_Mutation_p.C667Y	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	676					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		GCAATGCAGTGCTGCTTGGAG	0.463000													23	26					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57579327	57579327	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57579327C>T	ENST00000243077.3	+	41	6943	c.6477C>T	c.(6475-6477)tgC>tgT	p.C2159C		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2159	EGF-like 9.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCAACGTGTGCGCGGTGGCCA	0.672000													9	24					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155261708	155261708	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155261708C>T	ENST00000392414.3	-	10	1477	c.1364G>A	c.(1363-1365)cGg>cAg	p.R455Q	PKLR_ENST00000342741.4_Missense_Mutation_p.R486Q	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	486					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	AGGTCGGTACCGAGACAGAAG	0.577000													17	28					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	403458	403458	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:403458C>T	ENST00000256509.2	+	13	2025	c.1383C>T	c.(1381-1383)tgC>tgT	p.C461C	CHL1_ENST00000397491.2_Silent_p.C445C	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	445	Ig-like C2-type 5.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix		p.C461C(1)		NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TCTTACATTGCGAGTTCTTTG	0.408000													23	48					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10231366	10231366	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:10231366G>A	ENST00000377157.3	+	24	3830	c.2769G>A	c.(2767-2769)gcG>gcA	p.A923A	UBE4B_ENST00000253251.8_Silent_p.A1039A|UBE4B_ENST00000343090.6_Silent_p.A1168A	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	1168					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		CTCGGTTCGCGAAAGCCATTG	0.478000													27	52					0	0	1	0	0
TMEM181	57583	broad.mit.edu	37	6	159029451	159029451	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:159029451C>A	ENST00000367090.3	+	9	1182	c.1171C>A	c.(1171-1173)Ctg>Atg	p.L391M		NM_020823.1	NP_065874.1	Q9P2C4	TM181_HUMAN	transmembrane protein 181	391					pathogenesis	integral to membrane	toxin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)	22		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		CCTGTGCGCCCTGCTGCTCTT	0.617000													23	50					3.5997e-14	3.92294e-14	1	1	0
TMEM132E	124842	broad.mit.edu	37	17	32964564	32964564	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:32964564C>T	ENST00000321639.5	+	10	2596	c.2268C>T	c.(2266-2268)ggC>ggT	p.G756G		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	756						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		GCCCGCCGGGCTCTGCGCTAC	0.746000													6	11					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38131003	38131003	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38131003C>T	ENST00000406386.3	+	9	4915	c.4660C>T	c.(4660-4662)Cga>Tga	p.R1554*	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1554					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CTCTGAGAGGCGACCCGAGCT	0.677000											OREG0026548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	43					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60242433	60242433	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:60242433G>A	ENST00000269499.5	+	13	3537	c.3119G>A	c.(3118-3120)gGa>gAa	p.G1040E	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.G719E	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	1040					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						CCAATGCCTGGACCAATGTAC	0.468000													19	15					0	0	1	0	0
TP53TG5	27296	broad.mit.edu	37	20	44003714	44003714	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:44003714C>T	ENST00000372726.3	-	4	889	c.733G>A	c.(733-735)Gca>Aca	p.A245T	SYS1-DBNDD2_ENST00000452133.1_Intron|SYS1_ENST00000426004.1_3'UTR|TP53TG5_ENST00000537995.1_Missense_Mutation_p.A229T|SYS1-DBNDD2_ENST00000475242.1_Intron	NM_014477.2	NP_055292.1	Q9Y2B4	T53G5_HUMAN	TP53 target 5	245					intracellular signal transduction|negative regulation of cell growth	cytoplasm|nucleus				central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	12						TCAAGTGATGCGGAGCAGAAG	0.617000													23	29					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101636947	101636947	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:101636947G>A	ENST00000342239.3	-	17	4858	c.4767C>T	c.(4765-4767)taC>taT	p.Y1589Y	DNMBP_ENST00000324109.4_Silent_p.Y1565Y|DNMBP_ENST00000543621.1_Silent_p.Y811Y|DNMBP_ENST00000540316.1_Silent_p.Y501Y			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1565					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TGGAGGGAACGTAGCCCTTCT	0.517000													37	60					0	0	1	0	0
LXN	56925	broad.mit.edu	37	3	158390150	158390150	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:158390150C>T	ENST00000264265.3	-	1	332	c.118G>A	c.(118-120)Gcc>Acc	p.A40T	GFM1_ENST00000486715.1_Intron|GFM1_ENST00000478576.1_Intron|GFM1_ENST00000264263.5_Intron	NM_020169.3	NP_064554.3	Q9BS40	LXN_HUMAN	latexin	40						cytoplasm	metalloendopeptidase inhibitor activity|protein binding			breast(2)|endometrium(1)|kidney(2)	5			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TCCATGCTGGCTTGTTTGACC	0.602000											OREG0015899	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	108					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31500022	31500022	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31500022G>A	ENST00000330498.3	+	10	1228	c.1209G>A	c.(1207-1209)acG>acA	p.T403T		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	403					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						GCAGCAGCACGCTCTTCACCA	0.701000													17	9					0	0	1	0	0
DIEXF	27042	broad.mit.edu	37	1	210024741	210024741	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:210024741G>T	ENST00000491415.2	+	12	2277	c.2220G>T	c.(2218-2220)caG>caT	p.Q740H		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	740					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						GGGCGGCACAGATGCTACAGT	0.478000													21	31					7.4402e-23	8.28189e-23	1	1	0
B3GNT3	10331	broad.mit.edu	37	19	17918927	17918927	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17918927C>T	ENST00000318683.6	+	2	458	c.311C>T	c.(310-312)gCg>gTg	p.A104V	B3GNT3_ENST00000595387.1_Missense_Mutation_p.A104V	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	104					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						TCTAAGTGCGCGCAGCCGGTC	0.662000													13	27					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45026872	45026872	+	RNA	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45026872T>C	ENST00000454753.1	-	0	820							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				GCTGGAGCCCTCCATCACCTC	0.498000													6	4					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7679251	7679251	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:7679251C>T	ENST00000256861.6	-	5	670	c.592G>A	c.(592-594)Gca>Aca	p.A198T	ITIH5_ENST00000446830.2_5'UTR|ITIH5_ENST00000397145.2_Missense_Mutation_p.A198T|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397146.2_Missense_Mutation_p.A198T	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	198					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.A198T(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						TCCAGGGATGCGATGCCCGCG	0.657000													18	34					0	0	1	0	0
TAZ	6901	broad.mit.edu	37	X	153647888	153647888	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153647888G>A	ENST00000299328.5	+	6	756	c.467G>A	c.(466-468)gGc>gAc	p.G156D	TAZ_ENST00000350743.4_Missense_Mutation_p.G126D|TAZ_ENST00000369776.4_Missense_Mutation_p.G101D|TAZ_ENST00000369790.4_Missense_Mutation_p.G126D|TAZ_ENST00000351413.4_Missense_Mutation_p.G156D	NM_000116.3	NP_000107.1	Q16635	TAZ_HUMAN	tafazzin	156	Hydrophilic.				cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity			lung(1)	1	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCAGGAGATGGCGTCTACCAG	0.542000													27	6					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44893290	44893290	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:44893290T>C	ENST00000326047.4	+	33	3967	c.3818T>C	c.(3817-3819)gTc>gCc	p.V1273A	KIF15_ENST00000425755.1_Missense_Mutation_p.V908A	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	1273					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		CTAGAAGAAGTCCAAAGTGCC	0.383000													46	58					0	0	1	0	0
SLC29A2	3177	broad.mit.edu	37	11	66136900	66136900	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66136900G>A	ENST00000357440.2	-	3	443	c.215C>T	c.(214-216)aCg>aTg	p.T72M	SLC29A2_ENST00000544554.1_Missense_Mutation_p.T72M|SLC29A2_ENST00000311161.7_Missense_Mutation_p.T72M|SLC29A2_ENST00000546034.1_Missense_Mutation_p.T72M	NM_001532.2	NP_001523.2	Q14542	S29A2_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 2	72					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			breast(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10						GGACAGCAGCGTCACCCAATT	0.647000													4	131					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16488647	16488647	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:16488647C>T	ENST00000354981.2	-	7	812	c.655G>A	c.(655-657)Gtc>Atc	p.V219I	KIF16B_ENST00000378003.2_5'UTR|KIF16B_ENST00000408042.1_Missense_Mutation_p.V219I|KIF16B_ENST00000355755.3_Missense_Mutation_p.V219I	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	219	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						CTGCTACTGACGTCGTTCATC	0.493000													65	87					0	0	1	0	0
SNX19	399979	broad.mit.edu	37	11	130784663	130784663	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:130784663C>T	ENST00000265909.4	-	1	1741	c.1172G>A	c.(1171-1173)gGc>gAc	p.G391D	SNX19_ENST00000533214.1_Missense_Mutation_p.G391D|SNX19_ENST00000530356.1_Intron|SNX19_ENST00000528555.1_Intron|SNX19_ENST00000539184.1_Intron|SNX19_ENST00000533318.1_Intron	NM_014758.2	NP_055573.2	Q92543	SNX19_HUMAN	sorting nexin 19	391					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		GAGAAAGCTGCCTGGAGTCAT	0.532000													5	31					0	0	1	0	0
SH2B3	10019	broad.mit.edu	37	12	111885287	111885287	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:111885287G>A	ENST00000341259.2	+	6	1532	c.1175G>A	c.(1174-1176)cGg>cAg	p.R392Q	SH2B3_ENST00000538307.1_Missense_Mutation_p.R190Q	NM_005475.2	NP_005466.1	Q9UQQ2	SH2B3_HUMAN	SH2B adaptor protein 3	392	SH2.				blood coagulation	cytosol	signal transducer activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	10						TTCCTGGTGCGGCAGAGCGAG	0.627000													10	50					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141954939	141954939	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:141954939G>A	ENST00000552471.1	-	3	691	c.372C>T	c.(370-372)taC>taT	p.Y124Y	PRSS58_ENST00000547058.2_Silent_p.Y124Y			Q8IYP2	PRS58_HUMAN	protease, serine, 58	124	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						AGATAGTTTGGTAGGGCAGGT	0.403000													29	97					0	0	1	0	0
ZBTB46	140685	broad.mit.edu	37	20	62421673	62421673	+	Silent	SNP	G	G	A	rs142438754	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:62421673G>A	ENST00000245663.4	-	2	588	c.438C>T	c.(436-438)atC>atT	p.I146I	ZBTB46_ENST00000395104.1_Silent_p.I146I|ZBTB46_ENST00000302995.2_Silent_p.I146I	NM_025224.3	NP_079500.2	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					ACGAGGCGCCGATCTCGAACT	0.617000													9	9					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107406169	107406169	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:107406169G>T	ENST00000334504.7	-	41	4402	c.4169C>A	c.(4168-4170)cCt>cAt	p.P1390H	COL4A6_ENST00000545689.1_Missense_Mutation_p.P1366H|COL4A6_ENST00000538570.1_Missense_Mutation_p.P1333H|COL4A6_ENST00000372216.4_Missense_Mutation_p.P1391H|COL4A6_ENST00000394872.2_Missense_Mutation_p.P1391H	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	1391	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						AGTGAGGCCAGGGATGCCATC	0.582000									Alport syndrome with Diffuse Leiomyomatosis				54	13					5.57489e-27	6.2347e-27	1	1	0
LCN8	138307	broad.mit.edu	37	9	139649707	139649707	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139649707G>A	ENST00000371688.3	-	5	705	c.410C>T	c.(409-411)gCg>gTg	p.A137V	LCN8_ENST00000482893.1_5'UTR	NM_178469.3	NP_848564.2	Q6JVE9	LCN8_HUMAN	lipocalin 8	160					transport	extracellular region	binding			endometrium(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)	10	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;5.56e-06)|Epithelial(140;8.32e-05)		AGGCCGGGCCGCCAGGTAGAG	0.682000													19	33					0	0	1	0	0
AIM1L	55057	broad.mit.edu	37	1	26658018	26658018	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26658018C>T	ENST00000527815.1	-	14	1703	c.1654G>A	c.(1654-1656)Gcc>Acc	p.A552T	AIM1L_ENST00000308182.5_Missense_Mutation_p.A381T	NM_001039775.3	NP_001034864.2	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	381	Ricin B-type lectin.						sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|pancreas(1)|skin(2)	12		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		ACTGTGGAGGCGAGGCAGCCC	0.572000													7	27					0	0	1	0	0
UBE2Z	65264	broad.mit.edu	37	17	47004470	47004470	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:47004470G>T	ENST00000360943.5	+	7	1174	c.1039G>T	c.(1039-1041)Gac>Tac	p.D347Y		NM_023079.4	NP_075567.2	Q9H832	UBE2Z_HUMAN	ubiquitin-conjugating enzyme E2Z	347					apoptosis	cytoplasm|nucleus	ATP binding|ubiquitin-protein ligase activity										GACAGAGACAGACCTTCATGG	0.552000													10	9					2.17888e-05	2.24846e-05	1	1	0
RUFY4	285180	broad.mit.edu	37	2	218953985	218953985	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:218953985C>T	ENST00000374155.3	+	11	1983	c.1573C>T	c.(1573-1575)Cgc>Tgc	p.R525C	RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000344321.7_Missense_Mutation_p.R505C			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	505							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGAGAAGGACCGCCTGTGGCA	0.537000													7	13					0	0	1	0	0
CAPRIN1	4076	broad.mit.edu	37	11	34107948	34107948	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:34107948G>A	ENST00000341394.4	+	11	1408	c.1219G>A	c.(1219-1221)Gtt>Att	p.V407I	CAPRIN1_ENST00000530820.1_Missense_Mutation_p.V407I|CAPRIN1_ENST00000529307.1_Missense_Mutation_p.V326I|CAPRIN1_ENST00000532820.1_Missense_Mutation_p.V407I|CAPRIN1_ENST00000389645.3_Missense_Mutation_p.V407I	NM_005898.4	NP_005889.3	Q14444	CAPR1_HUMAN	cell cycle associated protein 1	407					negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)	18		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				GCCCCAGCTGGTTTGCCCTCC	0.378000													16	22					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1522221	1522221	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:1522221G>A	ENST00000389470.4	-	28	4149	c.4150C>T	c.(4150-4152)Cgc>Tgc	p.R1384C	INTS1_ENST00000404767.3_Missense_Mutation_p.R1222C			Q8N201	INT1_HUMAN	integrator complex subunit 1	1222					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CGGATCATGCGCAGCTTCAGC	0.667000													19	22					0	0	1	0	0
DFNA5	1687	broad.mit.edu	37	7	24742390	24742390	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:24742390G>A	ENST00000545231.1	-	11	1904	c.754C>T	c.(754-756)Ctg>Ttg	p.L252L	DFNA5_ENST00000409970.1_Silent_p.L252L|DFNA5_ENST00000409775.3_Silent_p.L416L|DFNA5_ENST00000419307.1_Silent_p.L252L|DFNA5_ENST00000342947.3_Silent_p.L416L			O60443	DFNA5_HUMAN	deafness, autosomal dominant 5	416					sensory perception of sound					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(3)|stomach(1)	19						AAGTGGCACAGTGTGGGAATG	0.502000													17	37					0	0	1	0	0
MCOLN1	57192	broad.mit.edu	37	19	7595240	7595240	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7595240G>A	ENST00000264079.6	+	12	1553	c.1428G>A	c.(1426-1428)acG>acA	p.T476T		NM_020533.2	NP_065394.1	Q9GZU1	MCLN1_HUMAN	mucolipin 1	476					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TGTTTGTGACGTTCGCCGCCA	0.607000													52	86					0	0	1	0	0
MCM8	84515	broad.mit.edu	37	20	5958549	5958549	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:5958549G>A	ENST00000378896.3	+	13	1800	c.1423G>A	c.(1423-1425)Gtg>Atg	p.V475M	MCM8_ENST00000378886.2_Missense_Mutation_p.V515M|MCM8_ENST00000378883.1_Missense_Mutation_p.V428M|MCM8_ENST00000265187.4_Missense_Mutation_p.V459M	NM_032485.4|NM_182802.1	NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	475	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						CCCACGTGGCGTGTATGTTTG	0.453000													3	43					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945874	72945874	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:72945874C>T	ENST00000311131.2	+	3	1137	c.670C>T	c.(670-672)Cga>Tga	p.R224*	P2RY2_ENST00000393597.2_Nonsense_Mutation_p.R224*|P2RY2_ENST00000393596.2_Nonsense_Mutation_p.R224*	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	224					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	CATGGCTCGGCGACTGCTAAA	0.647000													11	23					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59878708	59878708	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:59878708G>A	ENST00000259008.2	-	8	1313	c.1046C>T	c.(1045-1047)gCc>gTc	p.A349V	BRIP1_ENST00000577598.1_Missense_Mutation_p.A349V	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	349	Helicase ATP-binding.		A -> P (in FANCJ).		DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						ATATGGACAGGCCTTTAGTTT	0.408000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					60	74					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	132051856	132051856	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:132051856G>T	ENST00000286355.5	-	1	2816	c.724C>A	c.(724-726)Ctg>Atg	p.L242M	ADCY8_ENST00000377928.3_Missense_Mutation_p.L242M	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	242					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTGTACTGCAGGTACGTGTGG	0.647000										HNSCC(32;0.087)			5	17					1	1	1	1	0
SATB1	6304	broad.mit.edu	37	3	18462459	18462459	+	Translation_Start_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:18462459T>C	ENST00000338745.6	-	2	1735	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Start_Codon_SNP_p.M1V|SATB1_ENST00000417717.2_Start_Codon_SNP_p.M1V|SATB1_ENST00000493952.2_Start_Codon_SNP_p.M1V	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	1					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						AAATGATCCATACTCAGTCAC	0.443000													13	35					0	0	1	0	0
SNX13	23161	broad.mit.edu	37	7	17861183	17861183	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:17861183G>T	ENST00000409389.1	-	18	1999	c.1827C>A	c.(1825-1827)acC>acA	p.T609T	SNX13_ENST00000496855.1_5'UTR|SNX13_ENST00000428135.3_Silent_p.T598T			Q9Y5W8	SNX13_HUMAN	sorting nexin 13	609	PX.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(13)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(10;0.0261)|all_lung(11;0.0521)					AACGACGATAGGTTTTCCACA	0.398000													34	70					1.836e-18	2.02631e-18	1	1	0
KLHDC7A	127707	broad.mit.edu	37	1	18807720	18807720	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:18807720G>A	ENST00000400664.1	+	1	297	c.245G>A	c.(244-246)cGt>cAt	p.R82H		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	82	Poly-Arg.					integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCCAAGACGTCGGAGGAGC	0.642000													6	9					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74327724	74327724	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74327724C>T	ENST00000409262.3	+	9	3404	c.3404C>T	c.(3403-3405)aCc>aTc	p.T1135I		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1135							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCCAGCCTGACCTCCGTCAAT	0.577000													3	10					0	0	1	0	0
LNPEP	4012	broad.mit.edu	37	5	96315335	96315335	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:96315335C>T	ENST00000231368.5	+	2	1205	c.513C>T	c.(511-513)gcC>gcT	p.A171A	LNPEP_ENST00000395770.3_Silent_p.A157A	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	171					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		TTCCCACTGCCGTTGTGCCAC	0.463000													31	45					0	0	1	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138710412	138710412	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:138710412C>T	ENST00000389532.4	-	13	4074	c.4010G>A	c.(4009-4011)cGc>cAc	p.R1337H	CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.R1348H|CAMSAP1_ENST00000312405.6_Missense_Mutation_p.R1059H	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	1337						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GATGAGCTCGCGCCGCGCCTT	0.637000													18	26					0	0	1	0	0
GCNT4	51301	broad.mit.edu	37	5	74324764	74324764	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:74324764G>A	ENST00000322348.4	-	1	1960	c.1099C>T	c.(1099-1101)Cgc>Tgc	p.R367C		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	367					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	p.R367C(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		TTGACAAGGCGAGTCTTACTC	0.468000													4	37					0	0	1	0	0
CEP85L	387119	broad.mit.edu	37	6	118832471	118832471	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:118832471G>A	ENST00000368491.3	-	5	1868	c.1247C>T	c.(1246-1248)gCt>gTt	p.A416V	CEP85L_ENST00000368488.5_Missense_Mutation_p.A419V|CEP85L_ENST00000360290.3_Missense_Mutation_p.A314V|CEP85L_ENST00000419517.2_Missense_Mutation_p.A416V|CEP85L_ENST00000392500.3_Missense_Mutation_p.A419V	NM_001042475.2	NP_001035940.1	Q5SZL2	CF204_HUMAN	centrosomal protein 85kDa-like	416						centrosome											CTGCAAACTAGCCACATAAGA	0.343000													5	46					0	0	1	0	0
HOMEZ	57594	broad.mit.edu	37	14	23745118	23745118	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23745118G>T	ENST00000357460.5	-	2	1483	c.1319C>A	c.(1318-1320)cCa>cAa	p.P440Q	HOMEZ_ENST00000431326.2_Missense_Mutation_p.P442Q|HOMEZ_ENST00000561013.1_Missense_Mutation_p.P442Q	NM_020834.2	NP_065885.2	Q8IX15	HOMEZ_HUMAN	homeobox and leucine zipper encoding	440	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GCGGGTTGATGGTGGTGGTGT	0.567000													6	10					0.0215528	0.0217053	1	1	0
MRPL3	11222	broad.mit.edu	37	3	131186992	131186992	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:131186992C>T	ENST00000264995.3	-	9	984	c.837G>A	c.(835-837)aaG>aaA	p.K279K	MRPL3_ENST00000425847.2_Silent_p.K306K	NM_007208.3	NP_009139.1	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	279					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						TTATGTTGTGCTTTGTGTTTA	0.284000													22	54					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50552164	50552164	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50552164G>A	ENST00000262794.5	+	6	914	c.831G>A	c.(829-831)acG>acA	p.T277T	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Silent_p.T277T|MOV10L1_ENST00000545383.1_Silent_p.T277T|MOV10L1_ENST00000540615.1_Silent_p.T257T	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	277					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CACAGGTGACGCATTTTGGAA	0.413000													16	40					0	0	1	0	0
RCHY1	25898	broad.mit.edu	37	4	76434475	76434475	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:76434475C>T	ENST00000324439.5	-	2	520	c.122G>A	c.(121-123)cGc>cAc	p.R41H	RCHY1_ENST00000451788.1_Missense_Mutation_p.R41H|RCHY1_ENST00000514021.1_5'UTR|RCHY1_ENST00000513257.1_Missense_Mutation_p.R41H|RCHY1_ENST00000380840.2_Intron|RCHY1_ENST00000512706.1_Missense_Mutation_p.R19H	NM_001278536.1|NM_001278538.1|NM_001278539.1	NP_001265465.1|NP_001265467.1|NP_001265468.1	Q96PM5	ZN363_HUMAN	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase	41					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein autoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nuclear speck|ubiquitin ligase complex	electron carrier activity|p53 binding|protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|pancreas(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ATGACACAAGCGGCAAGTATA	0.353000													8	12					0	0	1	0	0
CHST5	23563	broad.mit.edu	37	16	75564025	75564025	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:75564025G>A	ENST00000336257.3	-	3	1652	c.258C>T	c.(256-258)ccC>ccT	p.P86P	CHST5_ENST00000541075.1_Silent_p.P92P|RP11-77K12.7_ENST00000460606.1_3'UTR	NM_024533.4	NP_078809.2	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	86					N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)	24						AGAAGACGTCGGGGTGCTGGC	0.677000													6	14					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60194301	60194301	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:60194301C>T	ENST00000267484.5	-	3	1436	c.1101G>A	c.(1099-1101)tcG>tcA	p.S367S		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	367					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		CGGTTTCATACGATAATCCCT	0.622000													10	4					0	0	1	0	0
CHID1	66005	broad.mit.edu	37	11	870159	870159	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:870159G>A	ENST00000449825.1	-	12	1401	c.1045C>T	c.(1045-1047)Cgc>Tgc	p.R349C	CHID1_ENST00000528581.1_Missense_Mutation_p.R374C|CHID1_ENST00000323578.8_Missense_Mutation_p.R349C|CHID1_ENST00000436108.2_Missense_Mutation_p.R349C|CHID1_ENST00000336845.5_Missense_Mutation_p.R374C|CHID1_ENST00000454838.2_Missense_Mutation_p.R374C|CHID1_ENST00000429789.2_Missense_Mutation_p.R318C|CHID1_ENST00000323541.7_Missense_Mutation_p.R379C	NM_001142675.1	NP_001136147.1	Q9BWS9	CHID1_HUMAN	chitinase domain containing 1	349					chitin catabolic process|innate immune response	extracellular region|lysosome	cation binding|chitinase activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	13		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.48e-25)|Epithelial(43;3.75e-24)|BRCA - Breast invasive adenocarcinoma(625;4.65e-05)|Lung(200;0.0624)|LUSC - Lung squamous cell carcinoma(625;0.0735)		CTCCCACTGCGGCTCCTGCAA	0.662000													14	34					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29346241	29346241	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:29346241C>T	ENST00000558402.1	+	5	753	c.154C>T	c.(154-156)Cgg>Tgg	p.R52W	APBA2_ENST00000411764.1_Missense_Mutation_p.R52W|APBA2_ENST00000561069.1_Missense_Mutation_p.R52W|APBA2_ENST00000558330.1_Missense_Mutation_p.R52W|APBA2_ENST00000558259.1_Missense_Mutation_p.R52W			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	52					nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGCTGCCCTGCGGCCAGAGAG	0.657000													20	33					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36269821	36269821	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:36269821G>T	ENST00000394571.2	+	6	959	c.959G>T	c.(958-960)gGa>gTa	p.G320V	PNPLA1_ENST00000388715.3_Missense_Mutation_p.G225V|PNPLA1_ENST00000312917.5_Missense_Mutation_p.G234V	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	320					lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						AAAGGGGATGGAAGGGGCAGC	0.572000											OREG0017382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	22					2.17888e-05	2.24846e-05	1	1	0
TDRD1	56165	broad.mit.edu	37	10	115982440	115982440	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:115982440C>T	ENST00000251864.2	+	21	3138	c.2985C>T	c.(2983-2985)gaC>gaT	p.D995D	TDRD1_ENST00000422662.1_Silent_p.D599D|TDRD1_ENST00000369280.1_Silent_p.D995D|TDRD1_ENST00000369281.2_Silent_p.D881D|TDRD1_ENST00000369282.1_Silent_p.D995D	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	995	Tudor 4.				DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		GAATTGGAGACGCATGCTGTG	0.373000													27	46					0	0	1	0	0
AC011537.3	0	broad.mit.edu	37	19	15880739	15880739	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:15880739G>A	ENST00000595525.1	+	0	529				CYP4F24P_ENST00000587443.2_RNA																							ACATGAAGGTGTCAGCCTCTG	0.512000													6	14					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152771925	152771925	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152771925C>A	ENST00000367255.5	-	27	3831	c.3230G>T	c.(3229-3231)aGg>aTg	p.R1077M	SYNE1_ENST00000367248.3_Missense_Mutation_p.R1067M|SYNE1_ENST00000367253.4_Missense_Mutation_p.R1077M|SYNE1_ENST00000448038.1_Missense_Mutation_p.R1084M|SYNE1_ENST00000413186.2_Missense_Mutation_p.R1077M|SYNE1_ENST00000341594.5_Missense_Mutation_p.R1143M|SYNE1_ENST00000423061.1_Missense_Mutation_p.R1084M|SYNE1_ENST00000265368.4_Missense_Mutation_p.R1077M	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1077					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAGCTGTAACCTTTTCTCACA	0.453000										HNSCC(10;0.0054)			29	91					3.1745e-13	3.44526e-13	1	1	0
TVP23B	51030	broad.mit.edu	37	17	18694224	18694224	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18694224G>A	ENST00000307767.8	+	3	410	c.111G>A	c.(109-111)tcG>tcA	p.S37S	TVP23B_ENST00000574226.1_Silent_p.S37S|TVP23B_ENST00000581733.1_5'UTR|TVP23B_ENST00000476139.1_5'UTR	NM_016078.4	NP_057162.4			trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)																		CAGTAGCATCGTTTTTCCACT	0.373000													5	150					0	0	1	0	0
GLB1	2720	broad.mit.edu	37	3	33109737	33109737	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:33109737G>A	ENST00000307363.5	-	4	586	c.442C>T	c.(442-444)Cgc>Tgc	p.R148C	GLB1_ENST00000399402.3_Missense_Mutation_p.R118C|GLB1_ENST00000445488.2_Missense_Mutation_p.R196C|GLB1_ENST00000307377.8_Intron	NM_000404.2	NP_000395.2	P16278	BGAL_HUMAN	galactosidase, beta 1	148			R -> C (in GM1G3).|R -> S (in GM1G1).		carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				TCGGAGGAGCGGAGAAGAATA	0.483000													21	27					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31426567	31426567	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:31426567C>T	ENST00000373747.3	-	15	2687	c.2588G>A	c.(2587-2589)gGg>gAg	p.G863E	PUM1_ENST00000373742.2_Missense_Mutation_p.G803E|PUM1_ENST00000257075.5_Missense_Mutation_p.G862E|PUM1_ENST00000373741.4_Missense_Mutation_p.G898E|PUM1_ENST00000424085.2_Missense_Mutation_p.G620E|PUM1_ENST00000440538.2_Missense_Mutation_p.G836E|PUM1_ENST00000426105.2_Missense_Mutation_p.G862E|PUM1_ENST00000423018.2_Missense_Mutation_p.G718E	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	862	PUM-HD.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TCACCTGGACCCATGCTGGTC	0.433000													22	128					0	0	1	0	0
ZNF205	7755	broad.mit.edu	37	16	3165484	3165484	+	Silent	SNP	G	G	A	rs144841352		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3165484G>A	ENST00000382192.3	+	3	391	c.186G>A	c.(184-186)tcG>tcA	p.S62S	ZNF205-AS1_ENST00000572691.1_RNA|ZNF205_ENST00000219091.4_Silent_p.S62S	NM_001278158.1|NM_003456.2	NP_001265087.1|NP_003447.2	O95201	ZN205_HUMAN	zinc finger protein 205	62					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20						AGGGGGCATCGCAGGAGGATG	0.612000													10	34					0	0	1	0	0
FBXO10	26267	broad.mit.edu	37	9	37541447	37541447	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:37541447G>A	ENST00000432825.2	-	2	367	c.319C>T	c.(319-321)Cga>Tga	p.R107*	FBXO10_ENST00000541829.1_Intron|RP11-613M10.8_ENST00000537239.2_3'UTR|RP11-613M10.8_ENST00000544475.1_5'UTR	NM_012166.2	NP_036298.2	Q9UK96	FBX10_HUMAN	F-box protein 10	107						ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(1)|endometrium(5)|large_intestine(11)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	34				GBM - Glioblastoma multiforme(29;0.0107)		AGGGTACGTCGTTCCCTCCTC	0.552000													19	22					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35707456	35707456	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35707456G>A	ENST00000314888.9	-	36	5015	c.4662C>T	c.(4660-4662)aaC>aaT	p.N1554N	TLN1_ENST00000540444.1_Silent_p.N1554N|TLN1_ENST00000464379.1_Intron	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1554	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ACTGGGCACGGTTCTCCTCTG	0.577000													14	16					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57522854	57522854	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:57522854A>G	ENST00000420713.1	+	3	354	c.242A>G	c.(241-243)gAg>gGg	p.E81G		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						AAGAGAAATGAGATGGTAGCC	0.413000													21	49					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140301970	140301970	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:140301970C>T	ENST00000275884.6	-	2	645	c.228G>A	c.(226-228)ccG>ccA	p.P76P	DENND2A_ENST00000537639.1_Silent_p.P76P|DENND2A_ENST00000492720.1_Silent_p.P76P|DENND2A_ENST00000496613.1_Silent_p.P76P			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	76										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					CCGTAGAGGACGGCAGATAAT	0.532000													15	71					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126136916	126136916	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:126136916T>C	ENST00000373631.3	+	11	3449	c.3448T>C	c.(3448-3450)Tgt>Cgt	p.C1150R	CRB2_ENST00000373629.2_Missense_Mutation_p.C818R	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	1150	EGF-like 14.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						TGGCAGCCCATGTGAGGGTGG	0.632000													8	20					0	0	1	0	0
DDX3X	1654	broad.mit.edu	37	X	41205566	41205566	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:41205566C>T	ENST00000399959.2	+	13	2255	c.1400C>T	c.(1399-1401)gCa>gTa	p.A467V	DDX3X_ENST00000441189.2_Intron|DDX3X_ENST00000478993.1_3'UTR|DDX3X_ENST00000542215.1_3'UTR|DDX3X_ENST00000457138.2_Missense_Mutation_p.A451V	NM_001193416.1|NM_001193417.1|NM_001356.3	NP_001180345.1|NP_001180346.1|NP_001347.3	O00571	DDX3X_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	467	Helicase C-terminal.|Necessary for interaction with XPO1.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			NS(3)|breast(8)|central_nervous_system(36)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84						GAAGGATACGCATGTACCAGC	0.463000										HNSCC(61;0.18)			9	17					0	0	1	0	0
DGCR14	8220	broad.mit.edu	37	22	19124849	19124849	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19124849C>A	ENST00000252137.6	-	8	1065	c.1022G>T	c.(1021-1023)gGc>gTc	p.G341V		NM_022719.2	NP_073210.1	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region gene 14	341					nervous system development	catalytic step 2 spliceosome				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	16	Colorectal(54;0.0993)					AAAAGCTGGGCCGGGTGTCCT	0.612000													59	57					4.90955e-16	5.38364e-16	1	1	0
MYOM2	9172	broad.mit.edu	37	8	2021562	2021562	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:2021562G>A	ENST00000262113.4	+	10	1243	c.1102G>A	c.(1102-1104)Gcc>Acc	p.A368T	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	368	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CGACCACAGCGCCTTCCTGTT	0.677000													16	21					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28573869	28573869	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:28573869C>T	ENST00000220562.4	+	3	1195	c.293C>T	c.(292-294)gCc>gTc	p.A98V	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Intron	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	98						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		CAGCTGGAGGCCAAGCGCCAA	0.592000													7	18					0	0	1	0	0
DHPS	1725	broad.mit.edu	37	19	12786735	12786735	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12786735C>T	ENST00000210060.7	-	9	1162	c.1027G>A	c.(1027-1029)Gcc>Acc	p.A343T	DHPS_ENST00000594424.1_Missense_Mutation_p.A301T|DHPS_ENST00000351660.5_Missense_Mutation_p.A296T	NM_001930.3	NP_001921.1	P49366	DHYS_HUMAN	deoxyhypusine synthase	343					peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)	8					Sulfadoxine(DB01299)	ACCAGGGAGGCGTCAGCATAG	0.602000											OREG0025272	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	19					0	0	1	0	0
TMEM180	79847	broad.mit.edu	37	10	104235671	104235671	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:104235671G>A	ENST00000238936.4	+	10	1721	c.1484G>A	c.(1483-1485)cGc>cAc	p.R495H	TMEM180_ENST00000366277.2_Missense_Mutation_p.R224H	NM_024789.3	NP_079065.2	Q14CX5	TM180_HUMAN	transmembrane protein 180	495						integral to membrane				breast(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|skin(1)	13		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CATGGGAGACGCCTGCACATG	0.607000													7	9					0	0	1	0	0
UNC45A	55898	broad.mit.edu	37	15	91488122	91488122	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:91488122G>A	ENST00000394275.2	+	12	1818	c.982_splice	c.e12-1	p.G328_splice	UNC45A_ENST00000418476.2_Splice_Site_p.G343_splice	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	343					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GTCTTTACAGGTCTGAAAAAG	0.507000													12	21					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117853142	117853142	+	Silent	SNP	G	G	A	rs7038329	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:117853142G>A	ENST00000350763.4	-	2	567	c.156C>T	c.(154-156)caC>caT	p.H52H	TNC_ENST00000345230.3_Silent_p.H52H|TNC_ENST00000423613.2_Silent_p.H52H|TNC_ENST00000535648.1_Silent_p.H52H|TNC_ENST00000537320.1_Silent_p.H52H|TNC_ENST00000346706.3_Silent_p.H52H|TNC_ENST00000340094.3_Silent_p.H52H|TNC_ENST00000542877.1_Silent_p.H52H|TNC_ENST00000341037.4_Silent_p.H52H	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	52					cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TGTTGTAAACGTGGTTAAACA	0.572000													27	52					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92401619	92401619	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:92401619A>G	ENST00000276609.3	+	16	1968	c.1729A>G	c.(1729-1731)Agt>Ggt	p.S577G	SLC26A7_ENST00000309536.2_Missense_Mutation_p.S577G|SLC26A7_ENST00000523719.1_Missense_Mutation_p.S577G|SLC26A7_ENST00000520249.1_3'UTR	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	577	STAS.					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CCTGGATTGCAGTGGATTTAC	0.388000													19	116					0	0	1	0	0
STK40	83931	broad.mit.edu	37	1	36809556	36809556	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:36809556G>A	ENST00000359297.2	-	8	916	c.909C>T	c.(907-909)acC>acT	p.T303T	STK40_ENST00000373129.3_Silent_p.T303T|STK40_ENST00000373130.3_Silent_p.T308T|STK40_ENST00000373132.3_Silent_p.T303T			Q8N2I9	STK40_HUMAN	serine/threonine kinase 40	303	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)	13		Myeloproliferative disorder(586;0.0393)				TGAGACACACGGTGTTCTCAG	0.642000													14	23					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57043078	57043078	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:57043078C>T	ENST00000308249.2	+	3	736	c.607C>T	c.(607-609)Cgt>Tgt	p.R203C		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	212					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity	p.R203S(1)		biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			GAAATTGGCCCGTTCTGTCTT	0.463000													87	168					0	0	1	0	0
DSN1	79980	broad.mit.edu	37	20	35399356	35399356	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:35399356C>A	ENST00000426836.1	-	3	647	c.275G>T	c.(274-276)aGg>aTg	p.R92M	DSN1_ENST00000373734.4_Intron|DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000373740.3_Missense_Mutation_p.R20M|DSN1_ENST00000373745.3_Missense_Mutation_p.R92M|DSN1_ENST00000373750.4_Missense_Mutation_p.R92M|DSN1_ENST00000448110.1_Missense_Mutation_p.R76M	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	92					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				GGATTGCCTCCTGTCTTGATA	0.507000													66	67					6.52717e-41	7.33653e-41	1	1	0
PIGG	54872	broad.mit.edu	37	4	524247	524247	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:524247G>A	ENST00000453061.2	+	11	2390	c.2284G>A	c.(2284-2286)Gtt>Att	p.V762I	PIGG_ENST00000504346.1_Missense_Mutation_p.V673I|PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000383028.4_Missense_Mutation_p.V629I|PIGG_ENST00000310340.5_Missense_Mutation_p.V754I	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	762					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						AGCTCGTTTTGTTTATGTCTT	0.363000													53	76					0	0	1	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134459741	134459741	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:134459741G>A	ENST00000372195.1	-	21	3107	c.2864C>T	c.(2863-2865)tCg>tTg	p.S955L	RAPGEF1_ENST00000372190.3_Missense_Mutation_p.S956L|RAPGEF1_ENST00000372189.3_Missense_Mutation_p.S938L			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	938	Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GATGGGCGCCGAGTCCAGGGC	0.672000													6	9					0	0	1	0	0
ZNF366	0	broad.mit.edu	37	5	71756333	71756333	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:71756333G>A	ENST00000318442.5	-	2	1481	c.991C>T	c.(991-993)Cac>Tac	p.H331Y		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	331					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		ACCTCGCTGTGCTGCATCATG	0.667000													11	15					0	0	1	0	0
HDHD1	8226	broad.mit.edu	37	X	6968396	6968396	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:6968396C>T	ENST00000381077.5	-	4	704	c.628G>A	c.(628-630)Gtg>Atg	p.V210M	HDHD1_ENST00000412827.2_Missense_Mutation_p.V167M|HDHD1_ENST00000424830.2_Missense_Mutation_p.V233M	NM_001178136.1|NM_012080.4	NP_001171607.1|NP_036212.3	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain containing 1	210					nucleotide metabolic process		metal ion binding|phosphatase activity			breast(2)|large_intestine(1)|lung(3)	6						GAATTCAGCACCAGGGTGGCC	0.607000													10	2					0	0	1	0	0
PCDHGC4	0	broad.mit.edu	37	5	140865341	140865341	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140865341G>A	ENST00000306593.1	+	1	601	c.601G>A	c.(601-603)Gat>Aat	p.D201N	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000518882.1_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGCCTTTGGATCGAGAGAA	0.592000													14	12					0	0	1	0	0
ZFAT	57623	broad.mit.edu	37	8	135524784	135524784	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:135524784C>A	ENST00000520727.1	-	15	3558	c.3259G>T	c.(3259-3261)Gaa>Taa	p.E1087*	ZFAT_ENST00000520356.1_Intron|ZFAT_ENST00000429442.2_Nonsense_Mutation_p.E1087*|ZFAT_ENST00000520214.1_Nonsense_Mutation_p.E1087*|ZFAT_ENST00000523399.1_Nonsense_Mutation_p.E1037*|ZFAT_ENST00000377838.3_Nonsense_Mutation_p.E1099*	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	1099					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGAACGTCTTCTTCGGCCTCT	0.522000													50	68					2.76378e-25	3.08483e-25	1	1	0
MAP3K1	4214	broad.mit.edu	37	5	56176631	56176631	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:56176631T>C	ENST00000399503.3	+	12	2179		c.e12+2			NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase						cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		TAAAAGCTGGTAATAACTTTT	0.398000													8	42					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77147399	77147399	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:77147399G>A	ENST00000461745.1	+	2	1196	c.296G>A	c.(295-297)cGc>cAc	p.R99H	ROBO2_ENST00000332191.8_Missense_Mutation_p.R99H|ROBO2_ENST00000487694.3_Missense_Mutation_p.R115H	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	99	Ig-like C2-type 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GTGCACGGGCGCAGGAGTAAA	0.532000													13	19					0	0	1	0	0
C9orf78	51759	broad.mit.edu	37	9	132597498	132597498	+	Translation_Start_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:132597498C>T	ENST00000372447.3	-	1	56	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_016520.2	NP_057604.1	Q9NZ63	CI078_HUMAN	chromosome 9 open reading frame 78	1										kidney(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)	13		Ovarian(14;0.00556)				GGACGACCGGCATGGTGACAA	0.697000													14	28					0	0	1	0	0
IMPA1	3612	broad.mit.edu	37	8	82571663	82571663	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:82571663C>T	ENST00000256108.5	-	9	1222	c.757G>A	c.(757-759)Gca>Aca	p.A253T	IMPA1_ENST00000449740.2_Missense_Mutation_p.A312T|IMPA1_ENST00000311489.4_3'UTR	NM_005536.3	NP_005527.1	P29218	IMPA1_HUMAN	inositol(myo)-1(or 4)-monophosphatase 1	253					inositol phosphate dephosphorylation|phosphatidylinositol biosynthetic process|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			NS(1)|cervix(1)|large_intestine(4)|lung(7)|prostate(2)|skin(2)|stomach(1)	18					Lithium(DB01356)	CTATTATTTGCAGCAATTACT	0.313000													19	32					0	0	1	0	0
BPIFB1	92747	broad.mit.edu	37	20	31889214	31889214	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31889214C>T	ENST00000253354.1	+	9	1084	c.923C>T	c.(922-924)tCt>tTt	p.S308F	BPIFB1_ENST00000464032.1_3'UTR	NM_033197.2	NP_149974.2	Q8TDL5	LPLC1_HUMAN	BPI fold containing family B, member 1	308						extracellular space	lipid binding										CTGTTGGACTCTGTGGTAAAC	0.542000													17	28					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18378157	18378157	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:18378157G>T	ENST00000441493.2	-	10	1694	c.1342C>A	c.(1342-1344)Ctg>Atg	p.L448M	MICAL3_ENST00000400561.2_Missense_Mutation_p.L448M|MICAL3_ENST00000383094.3_Missense_Mutation_p.L448M|MICAL3_ENST00000429452.1_Missense_Mutation_p.L448M|MICAL3_ENST00000444520.1_Missense_Mutation_p.L448M|MICAL3_ENST00000414725.2_Missense_Mutation_p.L448M|MICAL3_ENST00000585038.1_Missense_Mutation_p.L448M|MICAL3_ENST00000207726.7_Missense_Mutation_p.L448M	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	448						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		GTCTGAGGCAGCAACCTGTAA	0.478000													7	7					5.18039e-06	5.37127e-06	1	1	0
CNGA4	1262	broad.mit.edu	37	11	6261461	6261461	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6261461G>A	ENST00000379936.2	+	4	552	c.437G>A	c.(436-438)cGc>cAc	p.R146H	CNGA4_ENST00000533426.1_Intron	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	146					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGCTTTCTCCGCGCGCCCCGC	0.592000													15	79					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10426684	10426684	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:10426684C>T	ENST00000245503.5	-	38	5902	c.5518G>A	c.(5518-5520)Gct>Act	p.A1840T	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.A1840T	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1840					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ACAGCCTCAGCATTACGCTTT	0.478000													31	48					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23177435	23177435	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:23177435C>T	ENST00000389131.3	-	8	1802	c.1433G>A	c.(1432-1434)cGc>cAc	p.R478H		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	478	SRCR 4.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		GCCCAGCTGGCGGCAGACCAC	0.642000													12	17					0	0	1	0	0
PEX11B	8799	broad.mit.edu	37	1	145522818	145522818	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145522818C>T	ENST00000369306.3	+	4	828	c.679C>T	c.(679-681)Ctc>Ttc	p.L227F	PEX11B_ENST00000537888.1_Missense_Mutation_p.L213F	NM_003846.2	NP_003837.1	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	227	Interaction with PEX19 and peroxisome targeting.				peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CAAACTAGGCCTCTGGCGCTG	0.557000													14	78					0	0	1	0	0
ENTHD2	146705	broad.mit.edu	37	17	79202784	79202784	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79202784C>T	ENST00000374769.2	-	13	1747	c.1270G>A	c.(1270-1272)Gca>Aca	p.A424T	AC027601.1_ENST00000575922.1_RNA|ENTHD2_ENST00000300714.3_Missense_Mutation_p.A508T					ENTH domain containing 2																		TCTTTGGCTGCTGTCCTCTGG	0.667000													14	12					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43585431	43585431	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:43585431C>A	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							ATTGTTTATGCTATGTGTTTT	0.582000													7	17					0.000157383	0.000161063	1	1	0
DMXL1	1657	broad.mit.edu	37	5	118533507	118533507	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:118533507A>G	ENST00000311085.8	+	32	7681	c.7601A>G	c.(7600-7602)gAa>gGa	p.E2534G	DMXL1_ENST00000539542.1_Missense_Mutation_p.E2534G	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2534										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CAATGTTGGGAACAAGTTCTT	0.413000													23	95					0	0	1	0	0
HSPA4	3308	broad.mit.edu	37	5	132408971	132408971	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:132408971C>T	ENST00000304858.2	+	5	768	c.479C>T	c.(478-480)aCa>aTa	p.T160I		NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	160					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATGGATGCAACACAGATTGCT	0.338000													16	19					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33639817	33639817	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33639817C>T	ENST00000374316.5	+	23	3800	c.2740C>T	c.(2740-2742)Cgg>Tgg	p.R914W	ITPR3_ENST00000605930.1_Missense_Mutation_p.R914W			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	914					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						CAAGAATGTGCGGCGGTCCAT	0.632000													11	27					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151107924	151107924	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:151107924G>A	ENST00000474524.1	+	36	5541		c.e36+1		MED12L_ENST00000273432.4_Splice_Site	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTTACTCCAGGTATGTGATGA	0.478000													26	58					0	0	1	0	0
NADSYN1	55191	broad.mit.edu	37	11	71193052	71193052	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:71193052C>T	ENST00000319023.2	+	13	1319	c.1131C>T	c.(1129-1131)tgC>tgT	p.C377C	NADSYN1_ENST00000539574.1_Silent_p.C117C|NADSYN1_ENST00000530055.1_Silent_p.C6C|NADSYN1_ENST00000526039.2_3'UTR	NM_018161.4	NP_060631.2	Q6IA69	NADE_HUMAN	NAD synthetase 1	377	Ligase (By similarity).				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	25					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCCAGGTCTGCGAGGCCGTGA	0.622000													5	8					0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	132177679	132177679	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:132177679C>T	ENST00000374786.1	+	4	1102	c.623C>T	c.(622-624)gCc>gTc	p.A208V	NTM_ENST00000374784.1_Missense_Mutation_p.A208V|NTM_ENST00000474900.1_3'UTR|NTM_ENST00000539799.1_Missense_Mutation_p.A208V|NTM_ENST00000374791.3_Missense_Mutation_p.A208V|NTM_ENST00000427481.2_Missense_Mutation_p.A199V|NTM_ENST00000425719.2_Missense_Mutation_p.A208V	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	208	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						AATGACGTGGCCGCGCCCGTG	0.582000													13	19					0	0	1	0	0
MAP2K4	6416	broad.mit.edu	37	17	12013734	12013734	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:12013734A>T	ENST00000415385.3	+	7	762	c.709A>T	c.(709-711)Att>Ttt	p.I237F	MAP2K4_ENST00000353533.5_Missense_Mutation_p.I226F			P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	226	Protein kinase.				cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.0?(10)|p.?(1)		NS(1)|biliary_tract(2)|breast(22)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(26)|lung(15)|ovary(8)|pancreas(11)|skin(3)|stomach(2)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	100		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		CTTGAAAATTATTCACAGAGG	0.318000			"""D, Mis, N"""		"""pancreatic, breast, colorectal"""								15	74					0	0	1	0	0
PAGE2	203569	broad.mit.edu	37	X	55117849	55117849	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:55117849G>A	ENST00000374968.4	+	4	382	c.278G>A	c.(277-279)gGt>gAt	p.G93D	PAGE2_ENST00000374965.1_Missense_Mutation_p.G76D	NM_207339.2	NP_997222.1			P antigen family, member 2 (prostate associated)											endometrium(1)|large_intestine(2)|lung(1)|ovary(2)	6						GTCAGGGAGGGTATTATGCCC	0.398000													90	18					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5135490	5135490	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5135490G>A	ENST00000159111.4	+	15	2444	c.2226G>A	c.(2224-2226)ccG>ccA	p.P742P	KDM4B_ENST00000536461.1_Silent_p.P776P	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	742					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						ACACGGAGCCGCTGCCTGCCA	0.642000													6	7					0	0	1	0	0
SLC25A44	9673	broad.mit.edu	37	1	156180190	156180190	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156180190C>T	ENST00000359511.4	+	4	1085	c.913C>T	c.(913-915)Cga>Tga	p.R305*	SLC25A44_ENST00000423538.2_Nonsense_Mutation_p.R282*|SLC25A44_ENST00000469537.1_3'UTR	NM_014655.2	NP_055470.1	Q96H78	S2544_HUMAN	solute carrier family 25, member 44	305					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding	p.R305*(1)		breast(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Hepatocellular(266;0.158)					ACTCAGCCTCCGACCTGAGCT	0.572000													9	22					0	0	1	0	0
TSTA3	7264	broad.mit.edu	37	8	144695693	144695693	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144695693C>T	ENST00000425753.2	-	9	914		c.e9+1		TSTA3_ENST00000529064.1_Splice_Site	NM_003313.3	NP_003304.1	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B						'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|skin(1)	9	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	CCAGAGGATACGGTGACTTCC	0.687000													4	17					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140043502	140043502	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140043502G>A	ENST00000371561.3	+	4	1709	c.612G>A	c.(610-612)gtG>gtA	p.V204V	GRIN1_ENST00000315048.3_Silent_p.V204V|GRIN1_ENST00000371546.4_Silent_p.V225V|GRIN1_ENST00000371550.4_Silent_p.V204V|GRIN1_ENST00000350902.5_Silent_p.V204V|GRIN1_ENST00000371559.4_Silent_p.V204V|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371553.3_Silent_p.V225V|GRIN1_ENST00000371555.4_Silent_p.V225V|GRIN1_ENST00000371560.3_Silent_p.V225V	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	204					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCAAGAACGTGACGGCCCTGC	0.627000													3	9					0	0	1	0	0
TLR6	10333	broad.mit.edu	37	4	38830345	38830345	+	Silent	SNP	G	G	T	rs139523436		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:38830345G>T	ENST00000436693.2	-	2	869	c.750C>A	c.(748-750)acC>acA	p.T250T	TLR6_ENST00000381950.1_Silent_p.T250T	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	250					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AATTCAGTAAGGTTGAACCTC	0.343000													23	29					1.28384e-07	1.34682e-07	1	1	0
PCDHB10	0	broad.mit.edu	37	5	140573503	140573503	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140573503G>A	ENST00000239446.4	+	1	1562	c.1378G>A	c.(1378-1380)Gtc>Atc	p.V460I		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		460	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.V460F(1)		breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCCTGTTCGTCCGCGAGAA	0.637000													18	47					0	0	1	0	0
PHGDH	26227	broad.mit.edu	37	1	120269491	120269491	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:120269491C>T	ENST00000369407.3	+	3	1779	c.272C>T	c.(271-273)aCg>aTg	p.T91M	PHGDH_ENST00000369409.4_Missense_Mutation_p.T125M			O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	125					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	18	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	CCCCAGGCGACGGCTTCGATG	0.607000													5	16					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166831754	166831754	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:166831754G>T	ENST00000510118.1	-	21	2312	c.1972C>A	c.(1972-1974)Ctt>Att	p.L658I	RPS6KA2_ENST00000481261.2_Missense_Mutation_p.L544I|RPS6KA2_ENST00000405189.3_Missense_Mutation_p.L544I|RPS6KA2_ENST00000509742.1_5'UTR|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.L641I|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.L633I			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	633	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		CCCCCAGAAAGGGCATACTTC	0.453000													36	50					1.36161e-19	1.50697e-19	1	1	0
PRR5L	79899	broad.mit.edu	37	11	36472798	36472798	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:36472798C>T	ENST00000378867.3	+	9	980	c.625C>T	c.(625-627)Caa>Taa	p.Q209*	PRR5L_ENST00000527487.1_Intron|PRR5L_ENST00000311599.5_Nonsense_Mutation_p.Q136*|PRR5L_ENST00000389693.3_3'UTR|PRR5L_ENST00000530639.1_Nonsense_Mutation_p.Q209*	NM_024841.4	NP_079117.3	Q6MZQ0	PRR5L_HUMAN	proline rich 5 like	209										breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)	19						GAGTTATTTGCAACTGGAGGA	0.537000													32	39					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202074091	202074091	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:202074091G>T	ENST00000286186.6	+	9	1656	c.1221G>T	c.(1219-1221)caG>caT	p.Q407H	CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000313728.7_Missense_Mutation_p.Q340H|CASP10_ENST00000360132.3_3'UTR|CASP10_ENST00000272879.5_Missense_Mutation_p.Q407H|CASP10_ENST00000346817.5_Missense_Mutation_p.Q364H|CASP10_ENST00000448480.1_Missense_Mutation_p.Q364H	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	407					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						AAGAGATACAGCCTTCCGTAT	0.532000													25	39					1.85244e-09	1.96811e-09	1	1	0
ZCCHC14	23174	broad.mit.edu	37	16	87446014	87446014	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:87446014A>G	ENST00000268616.4	-	12	2119	c.1902T>C	c.(1900-1902)cgT>cgC	p.R634R		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	634					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding	p.R634R(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		TGATGGGCGGACGGGCGGCGT	0.607000													28	55					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301661	11301661	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:11301661C>T	ENST00000397056.1	+	3	1129	c.938C>T	c.(937-939)gCg>gTg	p.A313V	HRH1_ENST00000431010.2_Missense_Mutation_p.A313V|HRH1_ENST00000438284.2_Missense_Mutation_p.A313V	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	313					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	ATGCAGGCTGCGGCAGAGGGG	0.532000													20	40					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72843517	72843517	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72843517G>A	ENST00000293190.5	-	9	2077	c.1931C>T	c.(1930-1932)aCg>aTg	p.T644M	GRIN2C_ENST00000347612.4_Missense_Mutation_p.T644M	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	644					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CAGGTTGGCCGTGTAGCTGGC	0.582000													4	91					0	0	1	0	0
PPM1L	151742	broad.mit.edu	37	3	160783259	160783259	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:160783259G>A	ENST00000498165.1	+	3	744	c.643G>A	c.(643-645)Ggg>Agg	p.G215R	PPM1L_ENST00000480117.1_3'UTR|PPM1L_ENST00000464260.1_Missense_Mutation_p.G36R|PPM1L_ENST00000295839.9_Missense_Mutation_p.G88R	NM_139245.2	NP_640338.2	Q5SGD2	PPM1L_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1L	215	PP2C-like.				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			TGACTCGCGCGGGGTCCTGTG	0.488000													36	48					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100137804	100137804	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:100137804C>T	ENST00000375202.2	+	50	6259	c.4907C>T	c.(4906-4908)tCg>tTg	p.S1636L	RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000395220.1_3'UTR|CCDC180_ENST00000529487.1_Missense_Mutation_p.S1636L|CCDC180_ENST00000357054.1_Missense_Mutation_p.S1581L					coiled-coil domain containing 180																		CCAACATCATCGATTTCCACC	0.547000													20	40					0	0	1	0	0
ART5	116969	broad.mit.edu	37	11	3660067	3660067	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3660067C>T	ENST00000397067.3	-	4	828	c.699G>A	c.(697-699)caG>caA	p.Q233Q	ART5_ENST00000359918.4_Intron|ART5_ENST00000397068.3_Intron			Q96L15	NAR5_HUMAN	ADP-ribosyltransferase 5	158						extracellular region	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)|ovary(1)	11		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0336)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCCTGAGAGCTGGAACTCTC	0.597000													21	20					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166996046	166996046	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:166996046T>C	ENST00000061240.2	+	17	2852	c.2205T>C	c.(2203-2205)tcT>tcC	p.S735S	TLL1_ENST00000507499.1_Silent_p.S758S	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	735	EGF-like 2; calcium-binding (Potential).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ATGAATGCTCTAAGGATAATG	0.383000													18	70					0	0	1	0	0
RASA3	22821	broad.mit.edu	37	13	114757965	114757965	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:114757965C>T	ENST00000334062.7	-	22	2362	c.2241G>A	c.(2239-2241)atG>atA	p.M747I	RASA3_ENST00000389544.4_Missense_Mutation_p.M715I	NM_007368.2	NP_031394.2	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	747					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			ACTCACCCTGCATCTTCTCCA	0.602000													16	24					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154303924	154303924	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154303924G>A	ENST00000368489.3	+	6	407	c.407G>A	c.(406-408)cGc>cAc	p.R136H	ATP8B2_ENST00000426445.1_3'UTR|ATP8B2_ENST00000341822.2_Missense_Mutation_p.R122H|ATP8B2_ENST00000368487.3_Missense_Mutation_p.R103H	NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	122					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TTTCAGTTCCGCCACAAGAGC	0.502000													18	35					0	0	1	0	0
HIST1H4A	8359	broad.mit.edu	37	6	26021992	26021992	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:26021992G>A	ENST00000359907.3	+	1	86	c.86G>A	c.(85-87)gGc>gAc	p.G29D		NM_003538.3	NP_003529.1	P62805	H4_HUMAN	histone cluster 1, H4a	29					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			large_intestine(1)|skin(1)	2						AACATCCAGGGCATCACCAAG	0.617000													20	22					0	0	1	0	0
CHRNA10	57053	broad.mit.edu	37	11	3687551	3687551	+	Missense_Mutation	SNP	G	G	A	rs141309069		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3687551G>A	ENST00000250699.2	-	5	1210	c.1139C>T	c.(1138-1140)gCg>gTg	p.A380V	CHRNA10_ENST00000534359.1_3'UTR	NM_020402.2	NP_065135.2	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10 (neuronal)	380					elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			breast(1)|endometrium(2)|lung(3)|ovary(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	GCAAGGGCCCGCTGGGGGGCC	0.672000													22	47					0	0	1	0	0
ROM1	6094	broad.mit.edu	37	11	62381330	62381330	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62381330C>T	ENST00000278833.3	+	1	1118	c.577C>T	c.(577-579)Cgg>Tgg	p.R193W	ROM1_ENST00000534093.1_Intron	NM_000327.3	NP_000318.1	Q03395	ROM1_HUMAN	retinal outer segment membrane protein 1	193					cell adhesion|visual perception	integral to plasma membrane				central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	8						TCCCGGTGACCGGGATGTGGC	0.622000													8	26					0	0	1	0	0
CYP27B1	1594	broad.mit.edu	37	12	58158892	58158892	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:58158892G>A	ENST00000228606.4	-	4	901	c.692C>T	c.(691-693)tCc>tTc	p.S231F	RP11-571M6.13_ENST00000546609.1_RNA	NM_000785.3	NP_000776.1	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B, polypeptide 1	231					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|urinary_tract(1)	15	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	CAACAGCGTGGACACAAACAC	0.657000											OREG0021953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	19					0	0	1	0	0
LILRB5	0	broad.mit.edu	37	19	54760570	54760570	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54760570G>A	ENST00000450632.1	-	3	214	c.137C>T	c.(136-138)aCc>aTc	p.T46I	LILRB5_ENST00000316219.5_Missense_Mutation_p.T46I|LILRB5_ENST00000345866.6_Missense_Mutation_p.T46I|LILRB5_ENST00000449561.2_Missense_Mutation_p.T46I			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	46	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity	p.T46I(2)		NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACACCAGAGGGTCACGGGCTT	0.622000													11	99					0	0	1	0	0
AGO3	192669	broad.mit.edu	37	1	36474545	36474545	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:36474545C>T	ENST00000373191.4	+	8	1278	c.929C>T	c.(928-930)gCg>gTg	p.A310V	RP4-665N4.8_ENST00000466576.2_RNA|AGO3_ENST00000246314.6_Missense_Mutation_p.A76V	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3																		AGAACAGTAGCGCAGTATTTC	0.443000													20	38					0	0	1	0	0
KLHL28	54813	broad.mit.edu	37	14	45403751	45403751	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:45403751A>G	ENST00000396128.4	-	3	1029	c.910T>C	c.(910-912)Tac>Cac	p.Y304H	KLHL28_ENST00000355081.2_Missense_Mutation_p.Y318H	NM_017658.3	NP_060128.2	Q9NXS3	KLH28_HUMAN	kelch-like family member 28	304										breast(2)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						TGAGGAAAGTACATCTCCACa	0.338000													10	29					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6646561	6646561	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6646561G>A	ENST00000299441.3	-	19	7425	c.7014C>T	c.(7012-7014)gaC>gaT	p.D2338D		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	2338	Cadherin 22.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTGCTCAAAGTCCAGGGGCC	0.612000													13	11					0	0	1	0	0
COPB2	9276	broad.mit.edu	37	3	139088199	139088199	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:139088199G>A	ENST00000333188.5	-	12	1486	c.1305C>T	c.(1303-1305)ggC>ggT	p.G435G	COPB2_ENST00000507777.1_Silent_p.G406G	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	435					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						ATAAGAAGCCGCCGTAGATAC	0.368000													15	82					0	0	1	0	0
C9orf172	389813	broad.mit.edu	37	9	139738942	139738942	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139738942G>A	ENST00000436881.1	+	1	76	c.76G>A	c.(76-78)Gcg>Acg	p.A26T		NM_001080482.2	NP_001073951.2	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	26										endometrium(2)|large_intestine(1)|lung(6)	9						CCCGGGACCCGCGTCCAAGTG	0.662000													7	2					0	0	1	0	0
AGTR1	185	broad.mit.edu	37	3	148459669	148459669	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:148459669G>A	ENST00000542281.1	+	4	1293	c.847G>A	c.(847-849)Gcc>Acc	p.A283T	AGTR1_ENST00000474935.1_Missense_Mutation_p.A283T|AGTR1_ENST00000418473.2_Missense_Mutation_p.A283T|AGTR1_ENST00000402260.1_Missense_Mutation_p.A283T|AGTR1_ENST00000497524.1_Missense_Mutation_p.A283T|AGTR1_ENST00000475347.1_Missense_Mutation_p.A283T|AGTR1_ENST00000461609.1_Missense_Mutation_p.A283T|AGTR1_ENST00000404754.2_Missense_Mutation_p.A283T|AGTR1_ENST00000349243.3_Missense_Mutation_p.A283T	NM_031850.3	NP_114038.4	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	283					calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity	p.A283T(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	TGTGGACACGGCCATGCCTAT	0.363000													13	92					0	0	1	0	0
LIPG	9388	broad.mit.edu	37	18	47107896	47107896	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:47107896G>A	ENST00000261292.4	+	6	1183	c.905G>A	c.(904-906)cGc>cAc	p.R302H	LIPG_ENST00000577628.1_Missense_Mutation_p.R338H|LIPG_ENST00000580036.1_Missense_Mutation_p.R302H|LIPG_ENST00000427224.2_Missense_Mutation_p.R228H	NM_006033.2	NP_006024.1	Q9Y5X9	LIPE_HUMAN	lipase, endothelial	302					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(2)	18						GACTCCAATCGCTTCAAAAAG	0.478000													32	58					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78401186	78401186	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:78401186G>A	ENST00000397909.2	+	8	2041	c.1868G>A	c.(1867-1869)aGc>aAc	p.S623N	NAV3_ENST00000266692.7_Missense_Mutation_p.S623N|NAV3_ENST00000536525.2_Missense_Mutation_p.S623N|NAV3_ENST00000228327.6_Missense_Mutation_p.S623N			Q8IVL0	NAV3_HUMAN	neuron navigator 3	623						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CAGCAACATAGCCACCCGAAT	0.488000										HNSCC(70;0.22)			5	59					0	0	1	0	0
IGBP1	3476	broad.mit.edu	37	X	69354563	69354563	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:69354563C>T	ENST00000342206.6	+	2	878	c.379C>T	c.(379-381)Ccc>Tcc	p.P127S	IGBP1_ENST00000356413.4_Missense_Mutation_p.P127S			P78318	IGBP1_HUMAN	immunoglobulin (CD79A) binding protein 1	127					B cell activation|negative regulation of caspase activity|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|regulation of microtubule-based movement|response to interleukin-1|response to tumor necrosis factor|signal transduction	cytoplasm	protein phosphatase type 2A regulator activity			kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(2)	11						GTTTGAGCTGCCCAAAACCAT	0.453000													3	19					0	0	1	0	0
FERMT3	83706	broad.mit.edu	37	11	63974967	63974967	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:63974967G>A	ENST00000279227.5	+	2	226	c.131G>A	c.(130-132)gGg>gAg	p.G44E	FERMT3_ENST00000345728.5_Missense_Mutation_p.G44E	NM_178443.2	NP_848537.1	Q86UX7	URP2_HUMAN	fermitin family member 3	44					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						CACATCGGCGGGGTGCTCCTG	0.647000													24	40					0	0	1	0	0
ZNF555	148254	broad.mit.edu	37	19	2853573	2853573	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2853573G>A	ENST00000334241.4	+	4	1648	c.1510G>A	c.(1510-1512)Gca>Aca	p.A504T	ZNF555_ENST00000591539.1_Missense_Mutation_p.A503T|AC006130.3_ENST00000589365.1_RNA	NM_001172775.1|NM_152791.4	NP_001166246.1|NP_690004.4	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)|urinary_tract(4)	23				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGACATACCGCAGAGAAACT	0.418000													18	54					0	0	1	0	0
AC061992.1	0	broad.mit.edu	37	17	76422601	76422601	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:76422601G>A	ENST00000600087.1	+	1	193	c.193G>A	c.(193-195)Ggc>Agc	p.G65S	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Silent_p.A4279A|DNAH17_ENST00000389840.5_Silent_p.A4307A																							GGTAGGCCCGGGCCACCCACG	0.597000													10	26					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8182106	8182106	+	Missense_Mutation	SNP	C	C	T	rs149604266	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8182106C>T	ENST00000600128.1	-	28	3947	c.3533G>A	c.(3532-3534)cGg>cAg	p.R1178Q	FBN3_ENST00000270509.2_Missense_Mutation_p.R1178Q|FBN3_ENST00000601739.1_Missense_Mutation_p.R1178Q			Q75N90	FBN3_HUMAN	fibrillin 3	1178	EGF-like 16; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ACAGCTGCACCGGTAGCTGCC	0.612000													10	13					0	0	1	0	0
SEPN1	57190	broad.mit.edu	37	1	26135571	26135571	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26135571C>T	ENST00000361547.2	+	6	857	c.802C>T	c.(802-804)Cgc>Tgc	p.R268C	SEPN1_ENST00000354177.4_Missense_Mutation_p.R234C|SEPN1_ENST00000374315.1_Missense_Mutation_p.R234C	NM_020451.2	NP_065184.2	Q9NZV5	SELN_HUMAN	selenoprotein N, 1	268						endoplasmic reticulum membrane|extracellular region	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		TGTGAAGACCCGCTTTGCCCC	0.647000													30	51					0	0	1	0	0
SSTR1	0	broad.mit.edu	37	14	38679546	38679546	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:38679546G>A	ENST00000267377.2	+	3	1569	c.952G>A	c.(952-954)Gcc>Acc	p.A318T		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	318					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	CAACAGCTGCGCCAACCCCAT	0.582000													35	46					0	0	1	0	0
B4GALT6	9331	broad.mit.edu	37	18	29210963	29210963	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:29210963C>T	ENST00000306851.5	-	6	1031	c.735G>A	c.(733-735)atG>atA	p.M245I	B4GALT6_ENST00000237019.7_Missense_Mutation_p.M206I|B4GALT6_ENST00000383131.3_Missense_Mutation_p.M206I	NM_004775.3	NP_004766.2	Q9UBX8	B4GT6_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6	245					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(6)|pancreas(1)	20			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			AATGACGTGGCATTTCTCCAC	0.403000													5	77					0	0	1	0	0
C1QTNF6	114904	broad.mit.edu	37	22	37578308	37578308	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37578308G>A	ENST00000337843.2	-	3	832	c.757C>T	c.(757-759)Cgc>Tgc	p.R253C	C1QTNF6_ENST00000470655.1_5'UTR|C1QTNF6_ENST00000255836.6_Missense_Mutation_p.R129C|RP1-151B14.6_ENST00000419128.1_RNA|C1QTNF6_ENST00000397110.2_Missense_Mutation_p.R253C	NM_031910.3	NP_114116.3	Q9BXI9	C1QT6_HUMAN	C1q and tumor necrosis factor related protein 6	234	C1q.					collagen				breast(1)|large_intestine(2)|lung(6)|stomach(1)|upper_aerodigestive_tract(1)	11						GCGTTCTCGCGCTGGCGCTTG	0.647000													4	10					0	0	1	0	0
HOXA2	3199	broad.mit.edu	37	7	27142053	27142053	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:27142053T>A	ENST00000222718.5	-	1	377	c.67A>T	c.(67-69)Aca>Tca	p.T23S		NM_006735.3	NP_006726.1	O43364	HXA2_HUMAN	homeobox A2	23						nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|cervix(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	22						GGAAAAGATGTCAGGCACTCA	0.478000													29	54					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125521312	125521312	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:125521312T>C	ENST00000431078.1	+	15	2659	c.2295T>C	c.(2293-2295)acT>acC	p.T765T		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	765	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TAGTTATCACTGATACCGACA	0.408000													6	22					0	0	1	0	0
EXOSC5	56915	broad.mit.edu	37	19	41903140	41903140	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41903140C>T	ENST00000221233.4	-	1	244	c.94G>A	c.(94-96)Gcc>Acc	p.A32T	CTC-435M10.3_ENST00000540732.1_Intron|EXOSC5_ENST00000596905.1_Missense_Mutation_p.A32T|BCKDHA_ENST00000595085.1_Intron	NM_020158.3	NP_064543.3	Q9NQT4	EXOS5_HUMAN	exosome component 5	32					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|protein binding|RNA binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|urinary_tract(1)	7						TGTTCGCAGGCAAAGTGCCGG	0.587000													36	51					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4164102	4164102	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4164102C>T	ENST00000294016.3	-	2	1880	c.1342G>A	c.(1342-1344)Gtg>Atg	p.V448M		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	448	Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CAGCCCGCCACGCAGTAGTAA	0.602000													4	67					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31497156	31497156	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31497156G>A	ENST00000330498.3	+	4	429	c.410G>A	c.(409-411)cGc>cAc	p.R137H		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	137					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						GGCGGCCGCCGCATCCGCCTC	0.602000													12	20					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23396015	23396015	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23396015C>T	ENST00000324366.8	-	5	682	c.459G>A	c.(457-459)atG>atA	p.M153I	PRMT5_ENST00000553897.1_Missense_Mutation_p.M109I|PRMT5-AS1_ENST00000599580.1_RNA|PRMT5-AS1_ENST00000587245.2_RNA|PRMT5_ENST00000397441.2_Missense_Mutation_p.M136I|PRMT5_ENST00000216350.8_Missense_Mutation_p.M92I|PRMT5_ENST00000538452.1_Missense_Mutation_p.M47I|PRMT5_ENST00000553641.1_5'UTR|PRMT5-AS1_ENST00000590290.1_RNA|PRMT5_ENST00000397440.4_Intron	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	153					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		AGGGTACCCGCATCCAGAACT	0.458000													30	32					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21802475	21802475	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:21802475G>T	ENST00000382254.1	-	10	2143	c.1057C>A	c.(1057-1059)Ctt>Att	p.L353I	CDH12_ENST00000504376.2_Missense_Mutation_p.L353I|CDH12_ENST00000521384.1_5'UTR|CDH12_ENST00000522262.1_Missense_Mutation_p.L313I	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	353	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TCAAGGTGAAGGTTGGAAGCC	0.438000										HNSCC(59;0.17)			11	23					1.08611e-07	1.14056e-07	1	1	0
CPNE8	144402	broad.mit.edu	37	12	39047823	39047823	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:39047823C>T	ENST00000331366.5	-	20	1652	c.1556G>A	c.(1555-1557)aGc>aAc	p.S519N	CPNE8_ENST00000546603.1_5'UTR|CPNE8_ENST00000538596.2_Missense_Mutation_p.S188N|CPNE8_ENST00000360449.3_Missense_Mutation_p.S507N	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	519										NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				TCTAGCCATGCTCAGTATGTG	0.453000													14	29					0	0	1	0	0
CHST13	166012	broad.mit.edu	37	3	126260949	126260949	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:126260949G>A	ENST00000319340.2	+	3	604	c.554G>A	c.(553-555)cGc>cAc	p.R185H		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	185					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		TCGGCTTACCGCAACAAGCTC	0.726000													10	13					0	0	1	0	0
OR5K2	402135	broad.mit.edu	37	3	98216966	98216966	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:98216966G>A	ENST00000427338.1	+	1	519	c.442G>A	c.(442-444)Gcc>Acc	p.A148T	CLDND1_ENST00000502288.1_3'UTR	NM_001004737.1	NP_001004737.1	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K, member 2	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						GACCACAGGCGCCTTCATAGC	0.458000													8	81					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49206450	49206450	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49206450C>T	ENST00000425340.2	+	2	354	c.237C>T	c.(235-237)taC>taT	p.Y79Y	FUT2_ENST00000391876.4_Silent_p.Y79Y	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	79					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		TGGGCGAGTACGCCACACTGT	0.632000													5	9					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35851753	35851753	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:35851753G>A	ENST00000314607.6	+	11	1879	c.1799G>A	c.(1798-1800)cGc>cAc	p.R600H	ZMYM4_ENST00000373297.2_Intron	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	600					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GGAAGTATACGCAACTTCTGC	0.428000													28	41					0	0	1	0	0
GALNT3	2591	broad.mit.edu	37	2	166611458	166611458	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166611458G>T	ENST00000392701.3	-	8	2283	c.1508C>A	c.(1507-1509)cCt>cAt	p.P503H	GALNT3_ENST00000409882.1_Missense_Mutation_p.P241H	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	503					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						AGATATAACAGGATTAAGGTC	0.333000													9	41					0.00829132	0.00837884	1	1	0
CLCNKB	1188	broad.mit.edu	37	1	16376334	16376334	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16376334C>T	ENST00000375679.4	+	10	1002	c.891C>T	c.(889-891)agC>agT	p.S297S	CLCNKB_ENST00000375667.3_Silent_p.S128S	NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTGGGCAGCGCTTACCTCT	0.612000													65	114					0	0	1	0	0
GGA2	23062	broad.mit.edu	37	16	23497419	23497419	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:23497419G>A	ENST00000309859.4	-	8	797	c.715C>T	c.(715-717)Cga>Tga	p.R239*	GGA2_ENST00000567468.1_Intron	NM_015044.4	NP_055859.1	Q9UJY4	GGA2_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	239	GAT.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(48;0.0386)		ACATGGCTTCGCACTTCCTCC	0.572000													45	42					0	0	1	0	0
GPS2	2874	broad.mit.edu	37	17	7216788	7216788	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7216788G>A	ENST00000380728.2	-	8	935	c.634_splice	c.e8-1	p.A212_splice	GPS2_ENST00000389167.5_Splice_Site_p.A212_splice|RP11-542C16.2_ENST00000575474.1_3'UTR|GPS2_ENST00000391950.3_Splice_Site_p.A212_splice			Q13227	GPS2_HUMAN	G protein pathway suppressor 2	212					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			breast(1)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(4)	24		Prostate(122;0.157)				TGCCGAAGGAGCTGAGAAAGG	0.502000											OREG0024133	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	24					0	0	1	0	0
MUL1	79594	broad.mit.edu	37	1	20827309	20827309	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:20827309G>T	ENST00000264198.3	-	4	1069	c.933C>A	c.(931-933)tcC>tcA	p.S311S		NM_024544.2	NP_078820.2	Q969V5	MUL1_HUMAN	mitochondrial E3 ubiquitin protein ligase 1	311					activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(5)	11		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		GAAAGACGCAGGACTTGAAGC	0.597000													8	13					2.17888e-05	2.24846e-05	1	1	0
HAS1	3036	broad.mit.edu	37	19	52219536	52219536	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:52219536C>T	ENST00000540069.2	-	4	1091	c.1031G>A	c.(1030-1032)cGc>cAc	p.R344H	HAS1_ENST00000601714.1_Missense_Mutation_p.R352H|HAS1_ENST00000594621.1_Intron|HAS1_ENST00000222115.1_Missense_Mutation_p.R345H			Q92839	HAS1_HUMAN	hyaluronan synthase 1	345					cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding	p.R345H(1)		breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	40		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GCTGAGCATGCGGTTGGTGAG	0.522000													31	37					0	0	1	0	0
OLA1	29789	broad.mit.edu	37	2	174945974	174945974	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:174945974G>T	ENST00000284719.3	-	9	1118	c.872C>A	c.(871-873)gCt>gAt	p.A291D	OLA1_ENST00000344357.5_Missense_Mutation_p.A133D|OLA1_ENST00000409546.1_Missense_Mutation_p.A311D|OLA1_ENST00000428402.2_Intron|OLA1_ENST00000392560.2_5'UTR	NM_013341.3	NP_037473.3	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1	291					ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11						CTTTGGCAAAGCACTGAAATC	0.388000													31	42					1.08312e-15	1.18619e-15	1	1	0
ARVCF	421	broad.mit.edu	37	22	19966463	19966463	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19966463C>T	ENST00000263207.3	-	7	1828	c.1537G>A	c.(1537-1539)Gcc>Acc	p.A513T	ARVCF_ENST00000344269.3_Missense_Mutation_p.A450T|ARVCF_ENST00000406522.1_Missense_Mutation_p.A450T|ARVCF_ENST00000406259.1_Missense_Mutation_p.A513T|ARVCF_ENST00000401994.1_Missense_Mutation_p.A450T	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	513					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					GTCCACTCGGCGTCCCGTGGC	0.622000													8	21					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77256966	77256966	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:77256966C>T	ENST00000251089.2	-	9	1952	c.1840G>A	c.(1840-1842)Ggg>Agg	p.G614R	ANGEL1_ENST00000557179.1_Missense_Mutation_p.G179R	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	614										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		GTTCTGTTCCCATTCTCACAG	0.537000													23	31					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133219878	133219878	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:133219878C>T	ENST00000320574.5	-	35	4526	c.4483G>A	c.(4483-4485)Gcc>Acc	p.A1495T	POLE_ENST00000535270.1_Missense_Mutation_p.A1468T	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1495					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GCTTTGTGGGCCTGTGCGTGG	0.592000								DNA polymerases (catalytic subunits)					13	27					0	0	1	0	0
OR56A3	390083	broad.mit.edu	37	11	5968893	5968893	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5968893A>G	ENST00000329564.6	+	1	324	c.317A>G	c.(316-318)tAc>tGc	p.Y106C		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCCAGATGTACATCATGAAT	0.507000													5	144					0	0	1	0	0
NXN	64359	broad.mit.edu	37	17	704209	704209	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:704209G>A	ENST00000336868.3	-	8	1379	c.1288C>T	c.(1288-1290)Ctc>Ttc	p.L430F	NXN_ENST00000538650.1_Missense_Mutation_p.L121F|NXN_ENST00000537628.2_Missense_Mutation_p.L181F|NXN_ENST00000575801.1_Missense_Mutation_p.L322F	NM_022463.4	NP_071908.2	Q6DKJ4	NXN_HUMAN	nucleoredoxin	430					cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		TCCGGTTTGAGCTTCTCTGCT	0.577000													8	15					0	0	1	0	0
PADI6	353238	broad.mit.edu	37	1	17701957	17701957	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:17701957C>T	ENST00000434762.2	+	0	380							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	ACGAGGATGCCCCCGTGGGCA	0.622000													4	8					0	0	1	0	0
NR3C2	0	broad.mit.edu	37	4	149356756	149356756	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:149356756C>T	ENST00000355292.3	-	2	1619	c.1257G>A	c.(1255-1257)tcG>tcA	p.S419S	NR3C2_ENST00000511528.1_Silent_p.S419S|NR3C2_ENST00000344721.4_Silent_p.S419S|NR3C2_ENST00000512865.1_Silent_p.S419S|NR3C2_ENST00000358102.3_Silent_p.S419S|NR3C2_ENST00000342437.4_Silent_p.S419S			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	419	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	ATGAAGAATCCGAATTTATTT	0.393000													18	41					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39884916	39884916	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:39884916C>T	ENST00000341184.6	+	2	1779	c.1564C>T	c.(1564-1566)Ccg>Tcg	p.P522S		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	522					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					CGAGGGAAGGCCGCCCGCCCG	0.677000													8	5					0	0	1	0	0
ISPD	729920	broad.mit.edu	37	7	16255713	16255713	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:16255713C>T	ENST00000407010.2	-	9	1228	c.1229G>A	c.(1228-1230)gGg>gAg	p.G410E	AC004741.3_ENST00000438573.1_RNA|AC004741.3_ENST00000457112.1_RNA|AC004741.3_ENST00000582683.1_RNA|AC004741.3_ENST00000579293.1_RNA|ISPD_ENST00000399310.3_Missense_Mutation_p.G360E	NM_001101426.3	NP_001094896.1	A4D126	ISPD_HUMAN	isoprenoid synthase domain containing	410					isoprenoid biosynthetic process		nucleotidyltransferase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)	9						TATGAGAAGCCCATATAACAA	0.323000										Multiple Myeloma(15;0.18)			8	30					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133384773	133384773	+	Silent	SNP	G	G	A	rs143511800	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:133384773G>A	ENST00000204726.3	-	5	1440	c.882C>T	c.(880-882)gaC>gaT	p.D294D	GOLGA3_ENST00000456883.2_Silent_p.D294D|GOLGA3_ENST00000450791.2_Silent_p.D294D|GOLGA3_ENST00000545875.1_Silent_p.D294D|GOLGA3_ENST00000537452.1_Silent_p.D294D	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	294					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CCAGACGGTCGTCAGTGTCGG	0.597000													39	52					0	0	1	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261858	21261858	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:21261858G>A	ENST00000311620.5	+	2	1044	c.971G>A	c.(970-972)gGc>gAc	p.G324D		NM_145865.2	NP_665872.2	Q8N8V4	ANS4B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 4B	324										NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|lung(11)|ovary(2)	20				GBM - Glioblastoma multiforme(48;0.0565)		GAGGAAAACGGCCTCAAAGAT	0.517000													8	15					0	0	1	0	0
FLVCR2	55640	broad.mit.edu	37	14	76107352	76107352	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:76107352G>A	ENST00000238667.4	+	7	1646	c.1290G>A	c.(1288-1290)acG>acA	p.T430T	FLVCR2_ENST00000555027.1_Silent_p.T145T|FLVCR2_ENST00000539311.1_Silent_p.T225T|FLVCR2_ENST00000556856.1_Intron|FLVCR2_ENST00000556241.1_Intron|FLVCR2_ENST00000553587.1_Intron	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	430			T -> M (in PVHH).|T -> R (in PVHH).		transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		TGGAGCTCACGTACCCAGAAT	0.498000													7	58					0	0	1	0	0
ATG16L1	55054	broad.mit.edu	37	2	234173549	234173549	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:234173549G>A	ENST00000392017.4	+	5	658	c.401G>A	c.(400-402)tGt>tAt	p.C134Y	ATG16L1_ENST00000373525.5_Intron|ATG16L1_ENST00000392018.1_Missense_Mutation_p.C134Y|ATG16L1_ENST00000392020.4_Missense_Mutation_p.C134Y|ATG16L1_ENST00000347464.5_Intron	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	134					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		ATTGCAGAATGTTTGCAGACT	0.507000													36	44					0	0	1	0	0
BCR	613	broad.mit.edu	37	22	23596133	23596133	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:23596133C>T	ENST00000305877.8	+	2	2178	c.1427C>T	c.(1426-1428)gCg>gTg	p.A476V	BCR_ENST00000359540.3_Missense_Mutation_p.A476V	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	476					regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						AGCCGGGATGCGCTGGTCTCG	0.667000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								7	9					0	0	1	0	0
TMEM62	80021	broad.mit.edu	37	15	43444000	43444000	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43444000T>C	ENST00000260403.2	+	8	1158	c.879T>C	c.(877-879)ttT>ttC	p.F293F		NM_024956.3	NP_079232.3	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	293						integral to membrane				breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		ACCGGATTTTTGCTTTTGATC	0.358000													51	67					0	0	1	0	0
AKAP14	158798	broad.mit.edu	37	X	119048759	119048759	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:119048759G>A	ENST00000371431.3	+	5	633	c.359G>A	c.(358-360)aGt>aAt	p.S120N	AKAP14_ENST00000371425.4_Intron|AKAP14_ENST00000334356.2_Intron|AKAP14_ENST00000371423.2_Intron	NM_178813.5	NP_848928.1	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14	120						cytoplasm				endometrium(4)|large_intestine(1)|lung(8)	13						GTACACTGGAGTATCTCAACT	0.438000													4	79					0	0	1	0	0
EIF3M	10480	broad.mit.edu	37	11	32610621	32610621	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:32610621C>T	ENST00000531120.1	+	4	441	c.378C>T	c.(376-378)agC>agT	p.S126S	EIF3M_ENST00000524896.1_Intron	NM_006360.4	NP_006351.2	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3, subunit M	126						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16	Breast(20;0.109)					TGTATTGCAGCCTTATTAAAG	0.398000													33	48					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84456040	84456040	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:84456040C>T	ENST00000416219.2	+	8	758	c.669C>T	c.(667-669)gcC>gcT	p.A223A	ATP2C2_ENST00000420010.2_3'UTR|ATP2C2_ENST00000262429.4_Silent_p.A223A			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	223					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						CCGGGGAAGCCGAGCCATGTA	0.572000													19	29					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20071554	20071554	+	Silent	SNP	C	C	T	rs144410560	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:20071554C>T	ENST00000245957.5	+	7	709	c.633C>T	c.(631-633)taC>taT	p.Y211Y	C20orf26_ENST00000377306.1_Silent_p.Y211Y|C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000451767.2_Silent_p.Y211Y|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	211										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		AGGAAACTTACGGTGAATACT	0.433000													55	83					0	0	1	0	0
FRMD4A	55691	broad.mit.edu	37	10	13838573	13838573	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:13838573C>A	ENST00000357447.2	-	5	590	c.222G>T	c.(220-222)tgG>tgT	p.W74C	FRMD4A_ENST00000358621.4_Missense_Mutation_p.W59C|FRMD4A_ENST00000342409.2_Missense_Mutation_p.W90C|FRMD4A_ENST00000378503.1_Missense_Mutation_p.W74C	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	74	FERM.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						CTAGCTGAAGCCAGTTTAAGT	0.403000													14	71					1.05317e-09	1.12079e-09	1	1	0
ERBB3	2065	broad.mit.edu	37	12	56493687	56493687	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56493687G>T	ENST00000267101.3	+	25	3443	c.3003G>T	c.(3001-3003)gaG>gaT	p.E1001D	ERBB3_ENST00000549832.1_Missense_Mutation_p.E121D|ERBB3_ENST00000553131.1_Missense_Mutation_p.E242D|ERBB3_ENST00000450146.2_Missense_Mutation_p.E358D|ERBB3_ENST00000415288.2_Missense_Mutation_p.E942D	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	1001					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AGAAGCTAGAGGAAGTAGAGC	0.557000													11	35					0.0809354	0.0813244	1	1	0
DLG4	1742	broad.mit.edu	37	17	7097030	7097030	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7097030C>T	ENST00000399510.2	-	17	2528	c.1676G>A	c.(1675-1677)cGa>cAa	p.R559Q	DLG4_ENST00000399506.2_Missense_Mutation_p.R516Q|DLG4_ENST00000302955.6_Missense_Mutation_p.R513Q	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	516	Guanylate kinase-like.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding	p.R559Q(1)		breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						CGAGTCTTCTCGACCTGGTGG	0.612000													5	11					0	0	1	0	0
GPHB5	122876	broad.mit.edu	37	14	63784459	63784459	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:63784459G>A	ENST00000539258.1	-	0	161							Q86YW7	GPHB5_HUMAN	glycoprotein hormone beta 5							extracellular region	hormone activity			breast(1)|endometrium(1)|lung(4)|urinary_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(108;0.00372)|all cancers(60;0.0226)|BRCA - Breast invasive adenocarcinoma(234;0.0978)		TCACGGCACAGCCCACAAAGG	0.627000													9	28					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73729577	73729577	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73729577C>T	ENST00000200181.3	+	13	1648	c.1461C>T	c.(1459-1461)ggC>ggT	p.G487G	ITGB4_ENST00000579662.1_Silent_p.G487G|ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000450894.3_Silent_p.G487G|ITGB4_ENST00000339591.3_Silent_p.G487G|ITGB4_ENST00000449880.2_Silent_p.G487G	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	487	Cysteine-rich tandem repeats.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCAGGAGTGGCCAGACCTGCA	0.547000													7	15					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160755563	160755563	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:160755563G>T	ENST00000263636.4	-	2	129	c.102C>A	c.(100-102)gaC>gaA	p.D34E	LY75-CD302_ENST00000505052.1_Missense_Mutation_p.D34E|LY75_ENST00000554112.1_Missense_Mutation_p.D34E|LY75_ENST00000553424.1_Missense_Mutation_p.D34E|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.D34E	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TGGTGAAGGGGTCATTAGCTG	0.493000													20	83					4.16121e-05	4.27859e-05	1	1	0
LIMK2	3985	broad.mit.edu	37	22	31658176	31658176	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31658176G>A	ENST00000331728.4	+	6	722	c.608G>A	c.(607-609)cGc>cAc	p.R203H	LIMK2_ENST00000406516.1_Missense_Mutation_p.R125H|LIMK2_ENST00000444929.2_Intron|LIMK2_ENST00000333611.4_Missense_Mutation_p.R182H|LIMK2_ENST00000340552.4_Missense_Mutation_p.R182H	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	203	PDZ.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						CCTGGGGACCGCATCCTGGAG	0.547000													4	46					0	0	1	0	0
AGBL5	60509	broad.mit.edu	37	2	27276350	27276350	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27276350G>A	ENST00000360131.4	+	3	455	c.296G>A	c.(295-297)aGc>aAc	p.S99N	AGBL5_ENST00000323064.8_Missense_Mutation_p.S99N	NM_021831.5	NP_068603.4	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5	99					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	28	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AACAAGCAGAGCAAGCTGTAT	0.542000													21	30					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22039094	22039094	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:22039094C>T	ENST00000406385.1	+	10	666	c.606C>T	c.(604-606)gcC>gcT	p.A202A	PPIL2_ENST00000492445.2_Silent_p.A202A|PPIL2_ENST00000456792.2_Silent_p.A181A|PPIL2_ENST00000398831.3_Silent_p.A202A|PPIL2_ENST00000412327.1_Silent_p.A202A|PPIL2_ENST00000335025.7_Silent_p.A202A			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	202					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					ATACAAATGCCGAGACCCGAG	0.537000													16	24					0	0	1	0	0
STOML2	30968	broad.mit.edu	37	9	35100964	35100964	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35100964C>T	ENST00000356493.5	-	8	831	c.769G>A	c.(769-771)Gct>Act	p.A257T	STOML2_ENST00000452248.2_Missense_Mutation_p.A212T	NM_013442.1	NP_038470.1	Q9UJZ1	STML2_HUMAN	stomatin (EPB72)-like 2	257						cytoskeleton	receptor binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|prostate(1)	16			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ATTCGAATAGCTTCAGCTTTA	0.532000													76	99					0	0	1	0	0
SSH2	85464	broad.mit.edu	37	17	27963449	27963449	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27963449G>A	ENST00000269033.3	-	14	1869	c.1718C>T	c.(1717-1719)tCc>tTc	p.S573F	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Missense_Mutation_p.S600F	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	573					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TAAGGCTTTGGATGCATGGCA	0.413000													30	46					0	0	1	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18637464	18637464	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18637464G>A	ENST00000336349.5	-	3	592	c.357C>T	c.(355-357)acC>acT	p.T119T	SPTY2D1_ENST00000543776.1_5'UTR	NM_194285.2	NP_919261.2	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	119										breast(4)|cervix(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|skin(1)|stomach(1)	30						ACTCTCGGTCGGTTCCTTGGC	0.453000													36	95					0	0	1	0	0
COPS8	10920	broad.mit.edu	37	2	238002748	238002748	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:238002748G>A	ENST00000354371.2	+	5	1000	c.347G>A	c.(346-348)cGc>cAc	p.R116H	COPS8_ENST00000409629.1_Missense_Mutation_p.R116H|COPS8_ENST00000409334.1_Intron|COPS8_ENST00000392008.2_Missense_Mutation_p.R67H	NM_006710.4	NP_006701.1	Q99627	CSN8_HUMAN	COP9 signalosome subunit 8	116	PCI.				cullin deneddylation	cytoplasm|signalosome				large_intestine(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	4		Breast(86;0.000162)|Renal(207;0.00339)|all_hematologic(139;0.0123)|Ovarian(221;0.0694)|Acute lymphoblastic leukemia(138;0.0775)|all_lung(227;0.169)|all_neural(83;0.211)		Epithelial(121;7.41e-23)|OV - Ovarian serous cystadenocarcinoma(60;5.42e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000175)|Lung(119;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0258)		ACAAGGAGACGCGCCTTTGCC	0.473000													53	56					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72358201	72358201	+	Missense_Mutation	SNP	C	C	A	rs1042652		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:72358201C>A	ENST00000441259.1	-	3	1436	c.1276G>T	c.(1276-1278)Ggc>Tgc	p.G426C	PRF1_ENST00000373209.2_Missense_Mutation_p.G426C	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	426	C2.			G -> S (in Ref. 1; CAA31612).	apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						CCCCACAGGCCCCATGCTTGG	0.622000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				11	9					3.07112e-06	3.18879e-06	1	1	0
ANGPTL2	23452	broad.mit.edu	37	9	129870557	129870557	+	Missense_Mutation	SNP	C	C	T	rs138716830		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:129870557C>T	ENST00000373425.3	-	2	1071	c.454G>A	c.(454-456)Gcg>Acg	p.A152T	RALGPS1_ENST00000373436.1_Intron|RALGPS1_ENST00000394022.3_Intron|ANGPTL2_ENST00000373417.1_Intron|RALGPS1_ENST00000424082.2_Intron|RALGPS1_ENST00000373434.1_Intron|RALGPS1_ENST00000259351.5_Intron	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	152					multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						AGCTCCAACGCGTTGTCCCGC	0.597000													19	41					0	0	1	0	0
WFDC8	90199	broad.mit.edu	37	20	44184457	44184457	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:44184457G>A	ENST00000357199.4	-	4	406	c.328C>T	c.(328-330)Cgc>Tgc	p.R110C	WFDC8_ENST00000289953.2_Missense_Mutation_p.R110C	NM_181510.2	NP_852611.2	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8	110	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity	p.R110C(1)		central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|stomach(1)|upper_aerodigestive_tract(1)	15		Myeloproliferative disorder(115;0.0122)				AAATGCCAGCGCTGTGCCTCA	0.458000													25	41					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135282805	135282805	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:135282805C>T	ENST00000285968.6	+	15	2150	c.2124C>T	c.(2122-2124)tgC>tgT	p.C708C	NUP205_ENST00000440390.2_3'UTR	NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	708					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						GGGCCTTTTGCCAGCTTATTA	0.423000													103	122					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3779687	3779687	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3779687G>A	ENST00000262367.5	-	31	6170	c.5361C>T	c.(5359-5361)aaC>aaT	p.N1787N	CREBBP_ENST00000382070.3_Silent_p.N1749N	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1787	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AGCAGTTGGCGTTGCGGCACT	0.662000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						15	20					0	0	1	0	0
CFHR3	10878	broad.mit.edu	37	1	196759314	196759314	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:196759314A>G	ENST00000367425.4	+	5	845	c.753A>G	c.(751-753)gtA>gtG	p.V251V	CFHR3_ENST00000391985.3_Silent_p.V190V	NM_021023.5	NP_066303.2			complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						CTAATTATGTAACATGTAGTA	0.393000													42	6					0	0	1	0	0
PTPRJ	5795	broad.mit.edu	37	11	48145237	48145237	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:48145237G>A	ENST00000418331.2	+	5	1041	c.689G>A	c.(688-690)gGc>gAc	p.G230D	PTPRJ_ENST00000440289.2_Missense_Mutation_p.G230D	NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	230	Fibronectin type-III 2.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TGGAGCAATGGCAATGGCACT	0.493000													22	40					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1201802	1201802	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1201802G>A	ENST00000304460.10	+	1	93	c.37G>A	c.(37-39)Gcc>Acc	p.A13T		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	13					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CGGCCTAGACGCCCGGATCCC	0.682000													5	7					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42606103	42606103	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:42606103G>A	ENST00000359486.3	-	1	5345	c.5209C>T	c.(5209-5211)Cca>Tca	p.P1737S	TCF20_ENST00000335626.4_Missense_Mutation_p.P1737S|TCF20_ENST00000404876.1_Missense_Mutation_p.P38S	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1737					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						TTAGGAGGTGGATTCTTCGGG	0.512000													36	64					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7826973	7826973	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:7826973G>A	ENST00000338316.4	+	25	3354	c.3265G>A	c.(3265-3267)Gtg>Atg	p.V1089M	ADCY2_ENST00000537121.1_Missense_Mutation_p.V909M	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	1089					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						CCAGAGCAACGTGGCATCCTG	0.453000													25	41					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45288094	45288094	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:45288094G>A	ENST00000372192.3	-	22	3735	c.3605C>T	c.(3604-3606)aCt>aTt	p.T1202I	PTCH2_ENST00000447098.2_Intron	NM_003738.4	NP_003729.3	Q9Y6C5	PTC2_HUMAN	patched 2	1202					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					CTTTCACCCAGTGGCTGGACC	0.622000									Basal Cell Nevus syndrome				24	19					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27460093	27460093	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:27460093G>A	ENST00000337929.3	+	9	1579	c.1106G>A	c.(1105-1107)cGg>cAg	p.R369Q	IL21R_ENST00000564089.1_Missense_Mutation_p.R369Q|IL21R_ENST00000395754.4_Missense_Mutation_p.R369Q|IL21R-AS1_ENST00000563191.1_RNA|IL21R_ENST00000395755.1_Missense_Mutation_p.R369Q	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	369					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						GAGAGGGATCGGCCATACGGC	0.627000			T	BCL6	NHL								5	45					0	0	1	0	0
HMGXB4	10042	broad.mit.edu	37	22	35660782	35660782	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:35660782C>T	ENST00000216106.5	+	5	529	c.401C>T	c.(400-402)tCc>tTc	p.S134F	HMGXB4_ENST00000444518.2_Missense_Mutation_p.S25F	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	134					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGGGAGAAATCCTCTGGCTCT	0.532000													4	64					0	0	1	0	0
MUL1	79594	broad.mit.edu	37	1	20828657	20828657	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:20828657C>T	ENST00000264198.3	-	3	370	c.234G>A	c.(232-234)acG>acA	p.T78T		NM_024544.2	NP_078820.2	Q969V5	MUL1_HUMAN	mitochondrial E3 ubiquitin protein ligase 1	78					activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(5)	11		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		GGCTGTTAAGCGTTTCTTTAA	0.428000													8	105					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150029259	150029259	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150029259C>T	ENST00000394243.1	+	3	2528	c.2154C>T	c.(2152-2154)tcC>tcT	p.S718S	SYNPO_ENST00000522122.1_Silent_p.S718S|SYNPO_ENST00000307662.4_Silent_p.S474S|SYNPO_ENST00000519664.1_Silent_p.S474S	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	718					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGAACCTCTCCGAGGCCTCTG	0.652000													6	15					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56270427	56270427	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:56270427G>T	ENST00000327381.5	+	2	1096	c.996G>T	c.(994-996)caG>caT	p.Q332H		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	332						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			ATAGCTTACAGGCCCTCCAAG	0.478000													13	16					4.3838e-07	4.58243e-07	1	1	0
PTPRB	0	broad.mit.edu	37	12	70954643	70954643	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:70954643G>A	ENST00000334414.6	-	17	4284	c.4240C>T	c.(4240-4242)Cca>Tca	p.P1414S	PTPRB_ENST00000551525.1_Missense_Mutation_p.P1413S|PTPRB_ENST00000550358.1_Missense_Mutation_p.P1326S|PTPRB_ENST00000550857.1_Missense_Mutation_p.P1106S|PTPRB_ENST00000451516.2_Missense_Mutation_p.P1106S|PTPRB_ENST00000538708.1_Missense_Mutation_p.P1106S|PTPRB_ENST00000261266.5_Missense_Mutation_p.P1196S	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1196	Fibronectin type-III 16.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CCAGAGGCTGGACTCCAGTTG	0.473000													30	41					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43439705	43439705	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:43439705G>A	ENST00000406070.2	-	0	377				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TCCACTGTATGCAGGCCCATA	0.408000													46	238					0	0	1	0	0
BTRC	8945	broad.mit.edu	37	10	103292116	103292116	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:103292116C>T	ENST00000370187.3	+	8	1023	c.905C>T	c.(904-906)aCa>aTa	p.T302I	BTRC_ENST00000393441.4_Missense_Mutation_p.T261I|BTRC_ENST00000408038.2_Missense_Mutation_p.T266I	NM_033637.3	NP_378663.1	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing E3 ubiquitin protein ligase	302					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				endometrium(4)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	27		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CGAAGTGAAACAAGCAAAGGA	0.398000													41	46					0	0	1	0	0
MXI1	4601	broad.mit.edu	37	10	112038952	112038952	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:112038952G>A	ENST00000332674.5	+	4	656	c.452G>A	c.(451-453)cGc>cAc	p.R151H	MXI1_ENST00000369612.1_Missense_Mutation_p.R48H|MXI1_ENST00000393134.1_Missense_Mutation_p.R74H|MXI1_ENST00000239007.7_Missense_Mutation_p.R84H|MXI1_ENST00000361248.4_Missense_Mutation_p.R38H|MXI1_ENST00000485566.1_3'UTR	NM_130439.3	NP_569157.2	P50539	MXI1_HUMAN	MAX interactor 1, dimerization protein	84					cytoplasmic sequestering of transcription factor|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(1)	10		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;1.33e-05)|all cancers(201;0.000277)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GCTCATCTGCGCCTTTGTTTA	0.383000													14	19					0	0	1	0	0
MAN2C1	4123	broad.mit.edu	37	15	75648507	75648507	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75648507G>A	ENST00000565683.1	-	25	3002	c.2991C>T	c.(2989-2991)caC>caT	p.H997H	MAN2C1_ENST00000563622.1_Silent_p.H881H|MAN2C1_ENST00000569482.1_Silent_p.H957H|MAN2C1_ENST00000267978.5_Silent_p.H980H	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	980					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						CGTGGCTGCCGTGGGCCTCAT	0.692000													5	15					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152473249	152473249	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152473249G>T	ENST00000367255.5	-	134	24758	c.24157C>A	c.(24157-24159)Ctg>Atg	p.L8053M	SYNE1_ENST00000354674.4_Missense_Mutation_p.L208M|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000539504.1_Missense_Mutation_p.L208M|SYNE1_ENST00000448038.1_Missense_Mutation_p.L7982M|SYNE1_ENST00000356820.4_Missense_Mutation_p.L2577M|SYNE1_ENST00000341594.5_Missense_Mutation_p.L7665M|SYNE1_ENST00000423061.1_Missense_Mutation_p.L7982M|SYNE1_ENST00000265368.4_Missense_Mutation_p.L8053M	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8053					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGCTGCGTCAGGCACTCGTGG	0.532000										HNSCC(10;0.0054)			19	35					1.01871e-10	1.09092e-10	1	1	0
NPY4R	0	broad.mit.edu	37	10	47086845	47086845	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:47086845G>A	ENST00000374312.1	+	3	481	c.62G>A	c.(61-63)aGc>aAc	p.S21N	NPY4R_ENST00000395716.1_Missense_Mutation_p.S21N	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		GAAAACAGAAGCAAACCCCTG	0.493000													20	63					0	0	1	0	0
TSPAN5	10098	broad.mit.edu	37	4	99403179	99403179	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:99403179G>A	ENST00000305798.3	-	4	829	c.427C>T	c.(427-429)Ctc>Ttc	p.L143F	TSPAN5_ENST00000505184.1_Missense_Mutation_p.L72F|TSPAN5_ENST00000509168.1_5'UTR	NM_005723.3	NP_005714.2	P62079	TSN5_HUMAN	tetraspanin 5	143						integral to membrane				kidney(2)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(123;1.89e-07)		AAGTCTATGAGGTTTTGCAAA	0.373000													39	65					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40037071	40037071	+	Missense_Mutation	SNP	G	G	T	rs61607492		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:40037071G>T	ENST00000336649.4	+	8	940	c.940G>T	c.(940-942)Ggc>Tgc	p.G314C	CACNA1I_ENST00000400164.3_Missense_Mutation_p.G314C|CACNA1I_ENST00000401624.1_Missense_Mutation_p.G314C|CACNA1I_ENST00000407673.1_Missense_Mutation_p.G314C|CACNA1I_ENST00000404898.1_Missense_Mutation_p.G314C|CACNA1I_ENST00000402142.3_Missense_Mutation_p.G314C			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	314					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CAATGCCAGCGGCCTCTGTGT	0.607000													26	50					3.65163e-15	3.99483e-15	1	1	0
MARVELD3	91862	broad.mit.edu	37	16	71674559	71674559	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:71674559G>T	ENST00000299952.4	+	3	905	c.862G>T	c.(862-864)Gga>Tga	p.G288*	MARVELD3_ENST00000561682.1_Intron|MARVELD3_ENST00000565261.1_3'UTR|PHLPP2_ENST00000540628.1_3'UTR	NM_001017967.2	NP_001017967.2	Q96A59	MALD3_HUMAN	MARVEL domain containing 3	291	MARVEL.					integral to membrane				NS(1)|endometrium(3)|large_intestine(5)|lung(6)|skin(2)	17		Ovarian(137;0.125)				TTTACTCCAAGGAGCCAAGAG	0.587000													8	19					0.00307968	0.00311927	1	1	0
AHNAK	79026	broad.mit.edu	37	11	62288746	62288746	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62288746C>T	ENST00000378024.4	-	5	13417	c.13143G>A	c.(13141-13143)aaG>aaA	p.K4381K	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4381					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTTTGGGGGCCTTGATGTTCA	0.483000													6	192					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10944758	10944758	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:10944758T>C	ENST00000298232.7	-	10	789	c.422A>G	c.(421-423)aAc>aGc	p.N141S	TPTE_ENST00000361285.4_Missense_Mutation_p.N159S|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.N121S	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	159					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.N159I(1)|p.N141I(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATCTAAAATGTTAAATAAGTC	0.318000													20	119					0	0	1	0	0
SSRP1	6749	broad.mit.edu	37	11	57095226	57095226	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57095226G>A	ENST00000278412.2	-	14	2008	c.1742C>T	c.(1741-1743)gCa>gTa	p.A581V	RP11-872D17.4_ENST00000534162.1_RNA	NM_003146.2	NP_003137.1	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	581					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|prostate(4)	23						GATCTCGCCTGCCTTCTTGGA	0.542000													45	65					0	0	1	0	0
DUSP21	63904	broad.mit.edu	37	X	44703559	44703559	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:44703559G>A	ENST00000339042.4	+	1	311	c.181G>A	c.(181-183)Gta>Ata	p.V61I		NM_022076.3	NP_071359.3	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	61	Sufficient for mitochondrial localization (By similarity).|Tyrosine-protein phosphatase.					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|skin(3)	19						AGTGGTCAACGTATTCTTCGA	0.502000													41	4					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107756561	107756561	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:107756561G>A	ENST00000388781.3	-	3	163	c.80C>T	c.(79-81)gCc>gTc	p.A27V	LAMB4_ENST00000205386.4_Missense_Mutation_p.A27V|LAMB4_ENST00000414450.2_Missense_Mutation_p.A27V|LAMB4_ENST00000388780.3_Missense_Mutation_p.A27V	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	27	Laminin N-terminal.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						GGGATGACAGGCACCCCTGTT	0.532000													30	46					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71724517	71724517	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:71724517G>A	ENST00000393524.2	-	3	1247	c.514C>T	c.(514-516)Cgc>Tgc	p.R172C	PHLPP2_ENST00000356272.3_Missense_Mutation_p.R172C|PHLPP2_ENST00000568954.1_Missense_Mutation_p.R172C|PHLPP2_ENST00000360429.3_Missense_Mutation_p.R172C|PHLPP2_ENST00000567016.1_Missense_Mutation_p.R207C			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	172	PH.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						ACAACTAGGCGCTCAGCCCAC	0.468000													27	40					0	0	1	0	0
INS-IGF2	0	broad.mit.edu	37	11	2182031	2182031	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:2182031C>T	ENST00000397270.1	-	2	229	c.171G>A	c.(169-171)gaG>gaA	p.E57E	INS_ENST00000250971.3_Silent_p.E57E|INS_ENST00000381330.4_Silent_p.E57E|INS_ENST00000512523.1_Silent_p.E57E|INS_ENST00000397262.1_Silent_p.E57E	NM_001042376.2	NP_001035835.1	Q1WM24	Q1WM24_HUMAN		57					glucose metabolic process	extracellular region	hormone activity			haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	5		all_epithelial(84;0.00018)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;0.00256)|LUSC - Lung squamous cell carcinoma(625;0.0832)|Lung(200;0.156)		GGTCCTCTGCCTCCCGGCGGG	0.657000													20	26					0	0	1	0	0
OGG1	4968	broad.mit.edu	37	3	9796443	9796443	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9796443C>T	ENST00000302036.7	+	4	964	c.621C>T	c.(619-621)taC>taT	p.Y207Y	OGG1_ENST00000349503.5_Silent_p.Y207Y|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Silent_p.Y207Y|OGG1_ENST00000302003.7_Silent_p.Y207Y|OGG1_ENST00000449570.2_Silent_p.Y207Y|OGG1_ENST00000344629.7_Silent_p.Y207Y|OGG1_ENST00000339511.5_Silent_p.Y207Y	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	207					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					GTGCCCGTTACGTGAGTGCCA	0.622000								Base excision repair (BER), DNA glycosylases					8	14					0	0	1	0	0
SEC24A	10802	broad.mit.edu	37	5	134056760	134056760	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:134056760G>A	ENST00000398844.2	+	21	3331	c.3043G>A	c.(3043-3045)Gca>Aca	p.A1015T		NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	1015					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCAAAACTATGCATCAATTCC	0.343000													9	46					0	0	1	0	0
KLHDC10	23008	broad.mit.edu	37	7	129769308	129769308	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:129769308G>T	ENST00000335420.5	+	9	1145	c.1011G>T	c.(1009-1011)gaG>gaT	p.E337D		NM_014997.3	NP_055812.1	Q6PID8	KLD10_HUMAN	kelch domain containing 10	337										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|liver(2)|lung(10)|prostate(1)	17						ATAATGGAGAGGTGATCCTGG	0.433000													38	66					2.2871e-25	2.55332e-25	1	1	0
FAM109A	144717	broad.mit.edu	37	12	111801181	111801181	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:111801181C>T	ENST00000361483.3	-	4	529	c.90G>A	c.(88-90)ccG>ccA	p.P30P	FAM109A_ENST00000548163.1_Silent_p.P17P|FAM109A_ENST00000392658.5_Silent_p.P17P|FAM109A_ENST00000450786.2_5'UTR|FAM109A_ENST00000547838.2_Silent_p.P17P	NM_001177996.1	NP_001171467.1	Q8N4B1	SESQ1_HUMAN	family with sequence similarity 109, member A	17	PH.				endosome organization|receptor recycling|retrograde transport, endosome to Golgi	clathrin-coated vesicle|early endosome|recycling endosome|trans-Golgi network	protein homodimerization activity			breast(1)|endometrium(1)|lung(1)|ovary(1)	4						CATTGTCCACCGGGGCGTCAC	0.657000													8	7					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153035310	153035310	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153035310G>A	ENST00000538966.1	+	8	1885	c.1614G>A	c.(1612-1614)tgG>tgA	p.W538*	PLXNB3_ENST00000538282.1_Nonsense_Mutation_p.W125*|PLXNB3_ENST00000361971.5_Nonsense_Mutation_p.W515*|PLXNB3_ENST00000538776.1_Nonsense_Mutation_p.W168*|PLXNB3_ENST00000538543.1_Nonsense_Mutation_p.W65*	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	515					axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TGAACCAGTGGCTGTGGAGTT	0.677000													11	3					0	0	1	0	0
JUN	3725	broad.mit.edu	37	1	59247825	59247825	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:59247825T>C	ENST00000371222.2	-	1	1960	c.918A>G	c.(916-918)gcA>gcG	p.A306A		NM_002228.3	NP_002219.1	P05412	JUN_HUMAN	jun proto-oncogene	306	Leucine-zipper.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation by host of viral transcription|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein import into nucleus|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway		R-SMAD binding|Rho GTPase activator activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|kidney(2)|lung(5)|skin(1)	10	all_cancers(7;8.55e-07)				Arsenic trioxide(DB01169)|Irbesartan(DB01029)|Vinblastine(DB00570)	GTTTAAGCTGTGCCACCTGTT	0.527000			A		sarcoma						OREG0013518	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	84					0	0	1	0	0
ENO1	2023	broad.mit.edu	37	1	8930530	8930530	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:8930530G>A	ENST00000234590.4	-	4	340	c.221C>T	c.(220-222)gCg>gTg	p.A74V		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	74					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CAGGGCAGGCGCAATAGTTTT	0.458000													11	31					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18757550	18757550	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:18757550G>A	ENST00000304081.4	-	8	1329	c.1229C>T	c.(1228-1230)gCt>gTt	p.A410V	NT5C1B_ENST00000359846.2_Missense_Mutation_p.A470V|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.A470V|NT5C1B_ENST00000600945.1_Missense_Mutation_p.A470V	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GAAGAGGACAGCATCCCCATC	0.458000													4	41					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16265255	16265255	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16265255C>T	ENST00000375759.3	+	14	10951	c.10747C>T	c.(10747-10749)Cgt>Tgt	p.R3583C		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3583	SPOC.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCCCTGTGGCCGTGACCAAGA	0.597000													9	22					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687414	68687414	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:68687414C>T	ENST00000361320.4	+	2	1318	c.740C>T	c.(739-741)aCc>aTc	p.T247I	CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000494580.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	247						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						ATAGGACAGACCATGTCCTGG	0.463000													40	37					0	0	1	0	0
NSMCE2	286053	broad.mit.edu	37	8	126163439	126163439	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:126163439G>A	ENST00000287437.3	+	4	400	c.184G>A	c.(184-186)Gac>Aac	p.D62N	NSMCE2_ENST00000517315.1_Missense_Mutation_p.D2N|NSMCE2_ENST00000522563.1_Missense_Mutation_p.D62N	NM_173685.2	NP_775956.1	Q96MF7	NSE2_HUMAN	non-SMC element 2, MMS21 homolog (S. cerevisiae)	62					DNA recombination|DNA repair	nucleus	ligase activity|zinc ion binding			breast(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(2)	9	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			ATATAGTATGGACAAGGCAAT	0.318000													62	110					0	0	1	0	0
C6orf70	0	broad.mit.edu	37	6	170181436	170181436	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:170181436T>C	ENST00000588451.1	+	17	1969	c.1456T>C	c.(1456-1458)Tcg>Ccg	p.S486P	C6orf70_ENST00000366772.2_Missense_Mutation_p.S575P|C6orf70_ENST00000418781.3_Missense_Mutation_p.S549P|C6orf70_ENST00000392095.4_Missense_Mutation_p.S496P|C6orf70_ENST00000366773.3_Missense_Mutation_p.S622P			Q5T6L9	CF070_HUMAN		622						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		GTTTGTAAAGTCGATCTTGCA	0.313000													10	29					0	0	1	0	0
HEPN1	641654	broad.mit.edu	37	11	124789867	124789867	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:124789867T>C	ENST00000408930.5	+	1	722	c.221T>C	c.(220-222)gTc>gCc	p.V74A	HEPACAM_ENST00000298251.4_3'UTR	NM_001037558.2	NP_001032647.2	Q6WQI6	HEPN1_HUMAN	hepatocellular carcinoma, down-regulated 1	74						cytoplasm				large_intestine(1)|lung(1)|stomach(1)	3	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0287)		CATGGGCATGTCCTGGCTACA	0.517000													32	41					0	0	1	0	0
ZMYM5	9205	broad.mit.edu	37	13	20399047	20399047	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:20399047C>T	ENST00000337963.4	-	8	1844	c.1580G>A	c.(1579-1581)cGa>cAa	p.R527Q		NM_001142684.1	NP_001136156.1	Q9UJ78	ZMYM5_HUMAN	zinc finger, MYM-type 5	527						nucleus	zinc ion binding			kidney(1)|large_intestine(5)|lung(9)	15		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		attcaaaattcggggccacgt	0.388000													7	13					0	0	1	0	0
TSPYL6	388951	broad.mit.edu	37	2	54483161	54483161	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:54483161C>T	ENST00000317802.7	-	1	248	c.128G>A	c.(127-129)cGc>cAc	p.R43H	ACYP2_ENST00000303536.4_Intron|ACYP2_ENST00000394666.3_Intron|ACYP2_ENST00000606865.1_Intron|ACYP2_ENST00000607452.1_Intron	NM_001003937.2	NP_001003937.2	Q8N831	TSYL6_HUMAN	TSPY-like 6	43					nucleosome assembly	nucleus				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(1)|ovary(1)|skin(1)|stomach(2)	20						TGGCTCCAAGCGGCCATCAAA	0.602000													24	51					0	0	1	0	0
IGFBPL1	347252	broad.mit.edu	37	9	38414122	38414122	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:38414122G>A	ENST00000377694.1	-	2	561	c.539C>T	c.(538-540)gCt>gTt	p.A180V		NM_001007563.1	NP_001007564.1	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like 1	180	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding			endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	4				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		GGTAGGCACAGCCCTCACTTC	0.557000													16	30					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34863649	34863649	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:34863649G>A	ENST00000431794.3	-	15	1868	c.1346C>T	c.(1345-1347)gCc>gTc	p.A449V	MYO19_ENST00000268852.9_Intron	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	449	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CACCTGCTGGGCCCTTAGGTA	0.512000													9	6					0	0	1	0	0
SLC44A4	80736	broad.mit.edu	37	6	31838427	31838427	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31838427C>T	ENST00000544672.1	-	11	1058	c.762G>A	c.(760-762)ctG>ctA	p.L254L	SLC44A4_ENST00000229729.6_Silent_p.L330L|SLC44A4_ENST00000375562.4_Silent_p.L288L	NM_001178045.1	NP_001171516.1	Q53GD3	CTL4_HUMAN	solute carrier family 44, member 4	330						integral to membrane|plasma membrane	choline transmembrane transporter activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(1)|urinary_tract(2)	35					Choline(DB00122)	TCCGCTGCCGCAGGAAGATGA	0.632000													8	3					0	0	1	0	0
ZNF281	23528	broad.mit.edu	37	1	200377419	200377419	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:200377419C>T	ENST00000294740.2	-	2	1539	c.1415G>A	c.(1414-1416)aGa>aAa	p.R472K	ZNF281_ENST00000367352.3_Missense_Mutation_p.R436K|ZNF281_ENST00000367353.1_Missense_Mutation_p.R472K	NM_012482.3	NP_036614.1	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	472					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	27						TGTATTCTTTCTGCTTCCTTT	0.413000													25	32					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212115317	212115317	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:212115317G>A	ENST00000366994.3	-	20	2842	c.2738C>T	c.(2737-2739)gCc>gTc	p.A913V	INTS7_ENST00000469606.1_5'UTR|INTS7_ENST00000366993.3_Missense_Mutation_p.A899V|INTS7_ENST00000366992.3_Missense_Mutation_p.A893V|INTS7_ENST00000440600.2_Missense_Mutation_p.A864V	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	913					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TATACCATTGGCATCTTTCAC	0.408000													29	58					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128186435	128186435	+	Silent	SNP	C	C	T	rs151319700	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128186435C>T	ENST00000453608.2	+	8	1472	c.1464C>T	c.(1462-1464)ggC>ggT	p.G488G	PROC_ENST00000422777.3_Silent_p.G433G|PROC_ENST00000409048.1_Silent_p.G467G|PROC_ENST00000234071.3_Silent_p.G433G			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	433					blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	ACAACTACGGCGTTTACACCA	0.637000													35	66					0	0	1	0	0
CKMT2	1160	broad.mit.edu	37	5	80550292	80550292	+	Silent	SNP	G	G	A	rs146777847	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:80550292G>A	ENST00000424301.2	+	5	667	c.429G>A	c.(427-429)acG>acA	p.T143T	CTC-281B15.1_ENST00000512287.1_RNA|CTC-281B15.1_ENST00000502041.2_RNA|CTC-281B15.1_ENST00000500148.2_RNA|CTC-281B15.1_ENST00000501927.2_RNA|CTC-281B15.1_ENST00000511495.1_RNA|CTC-281B15.1_ENST00000505295.1_RNA|CKMT2_ENST00000254035.4_Silent_p.T143T|CKMT2_ENST00000437669.1_Silent_p.T143T|CTC-281B15.1_ENST00000503483.2_RNA	NM_001825.2	NP_001816.2	P17540	KCRS_HUMAN	creatine kinase, mitochondrial 2 (sarcomeric)	143					creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(4)|urinary_tract(1)	17		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	AGCACACAACGGATCTGGATG	0.572000													13	26					0	0	1	0	0
ZNF106	64397	broad.mit.edu	37	15	42740885	42740885	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42740885T>C	ENST00000263805.4	-	3	2777	c.2451A>G	c.(2449-2451)gtA>gtG	p.V817V	ZNF106_ENST00000565611.1_Silent_p.V2V|ZNF106_ENST00000565380.1_Silent_p.V45V	NM_022473.1	NP_071918.1			zinc finger protein 106																		GAACAAGGGGTACCATTTCTA	0.408000													13	26					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52850920	52850920	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52850920C>T	ENST00000266041.4	-	21	2547	c.2451G>A	c.(2449-2451)acG>acA	p.T817T	ITIH4_ENST00000346281.5_Silent_p.T801T|ITIH4_ENST00000406595.1_Silent_p.T787T|ITIH4_ENST00000485816.1_Silent_p.T822T	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	817				ET -> QR (in Ref. 5; AA sequence).	acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CTGAGAATAGCGTCTCCTTCC	0.587000													53	78					0	0	1	0	0
NFIB	4781	broad.mit.edu	37	9	14125766	14125766	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:14125766C>A	ENST00000380959.3	-	7	1399		c.e7-1		NFIB_ENST00000380953.1_Splice_Site|NFIB_ENST00000397581.2_Splice_Site|NFIB_ENST00000380934.4_Splice_Site|NFIB_ENST00000380924.1_Splice_Site|NFIB_ENST00000397575.3_Splice_Site|NFIB_ENST00000543693.1_Splice_Site|NFIB_ENST00000397579.2_Splice_Site	NM_005596.3	NP_005587.2	O00712	NFIB_HUMAN	nuclear factor I/B						anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		GAAGACATATCTGCGAGAAAC	0.428000			T	"""MYB, HGMA2"""	"""adenoid cystic carcinoma, lipoma"""								23	35					2.89027e-11	3.10618e-11	1	1	0
LRIG1	26018	broad.mit.edu	37	3	66430821	66430821	+	Missense_Mutation	SNP	C	C	T	rs57929900	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:66430821C>T	ENST00000383703.3	-	20	3682	c.3079G>A	c.(3079-3081)Gcg>Acg	p.A1027T	LRIG1_ENST00000496559.2_5'UTR|SLC25A26_ENST00000536651.1_3'UTR|LRIG1_ENST00000273261.3_Missense_Mutation_p.A1050T			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	1050						integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TGGGCTTCCGCGCGCTCTGGA	0.562000													4	91					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103410511	103410511	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:103410511G>A	ENST00000361246.2	-	30	4413	c.4125C>T	c.(4123-4125)agC>agT	p.S1375S		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1375	CNH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GGCACTGCACGCTGCCGGGAG	0.587000													16	33					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158902117	158902117	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:158902117G>T	ENST00000367097.3	+	8	2639	c.1282G>T	c.(1282-1284)Gac>Tac	p.D428Y	TULP4_ENST00000367094.2_Missense_Mutation_p.D428Y	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	428					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CAACATGAGAGACTTTGTCAG	0.582000													24	30					2.41591e-17	2.65831e-17	1	1	0
WDR25	79446	broad.mit.edu	37	14	100992319	100992319	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:100992319G>A	ENST00000335290.6	+	5	1440	c.1214G>A	c.(1213-1215)cGc>cAc	p.R405H	WDR25_ENST00000557502.1_3'UTR|WDR25_ENST00000542471.2_Missense_Mutation_p.R148H|WDR25_ENST00000554998.1_Missense_Mutation_p.R405H|WDR25_ENST00000402312.3_Missense_Mutation_p.R405H	NM_024515.4	NP_078791.3	Q64LD2	WDR25_HUMAN	WD repeat domain 25	405										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				TCAGCTGACCGCACCATTATT	0.542000													16	30					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86514598	86514598	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:86514598G>A	ENST00000297814.2	-	5	1723	c.1580C>T	c.(1579-1581)gCg>gTg	p.A527V	KIF27_ENST00000413982.1_Missense_Mutation_p.A527V|KIF27_ENST00000334204.2_Missense_Mutation_p.A527V	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	527					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						CACTTTTTGCGCTTCTTTCAA	0.363000													39	69					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164393760	164393760	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:164393760A>G	ENST00000280605.3	-	1	1287	c.1127T>C	c.(1126-1128)gTg>gCg	p.V376A		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	376						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GCCTAGTGCCACACTTACCAT	0.453000													30	47					0	0	1	0	0
ZER1	10444	broad.mit.edu	37	9	131505018	131505018	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131505018G>A	ENST00000291900.2	-	9	1772	c.1366C>T	c.(1366-1368)Cgg>Tgg	p.R456W		NM_006336.2	NP_006327.2	Q7Z7L7	ZER1_HUMAN	zyg-11 related, cell cycle regulator	456					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	15						CAGCAGTTCCGCTGCACCTGG	0.592000													4	7					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78320610	78320610	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78320610C>T	ENST00000582970.1	+	29	8618	c.8475C>T	c.(8473-8475)tgC>tgT	p.C2825C	RNF213_ENST00000336301.6_Silent_p.C898C|RNF213_ENST00000508628.2_Silent_p.C2874C	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TCCGGCAGTGCGCCCGCTTTC	0.607000													12	16					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139257921	139257921	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:139257921C>T	ENST00000406875.3	-	15	3443	c.3349G>A	c.(3349-3351)Gtg>Atg	p.V1117M	HIPK2_ENST00000428878.2_Missense_Mutation_p.V1090M	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	1117	Autoinhibitory domain (AID).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					AGGTGGGCCACGGTGCCGGTG	0.726000													15	11					0	0	1	0	0
ANKFY1	51479	broad.mit.edu	37	17	4085622	4085622	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4085622G>T	ENST00000341657.4	-	15	2010	c.1975C>A	c.(1975-1977)Ctc>Atc	p.L659I	ANKFY1_ENST00000574367.1_Missense_Mutation_p.L660I|ANKFY1_ENST00000570535.1_Missense_Mutation_p.L701I|CYB5D2_ENST00000573984.1_Intron	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	659						endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						GCCAGCTGGAGGGCTGTCTCC	0.567000													36	64					1.08052e-11	1.16368e-11	1	1	0
ACCS	84680	broad.mit.edu	37	11	44099415	44099415	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:44099415C>T	ENST00000263776.8	+	8	1109	c.675C>T	c.(673-675)cgC>cgT	p.R225R		NM_001127219.1|NM_032592.3	NP_001120691.1|NP_115981.1	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)	225							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(4)|endometrium(3)|large_intestine(11)|lung(15)|ovary(1)|skin(1)	35						TAGACACACGCCCCTTCCAGC	0.552000													3	15					0	0	1	0	0
CDK13	8621	broad.mit.edu	37	7	40133805	40133805	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:40133805G>A	ENST00000181839.4	+	14	4370	c.3765G>A	c.(3763-3765)ctG>ctA	p.L1255L	CDK13_ENST00000340829.5_Silent_p.L1195L	NM_003718.4|NM_031267.3	NP_003709.3|NP_112557.2	Q14004	CDK13_HUMAN	cyclin-dependent kinase 13	1255					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(2)|prostate(2)|skin(5)|stomach(2)|urinary_tract(1)	49						CTCGAATTCTGCCTCCTGACC	0.502000													19	39					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117810616	117810616	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:117810616C>T	ENST00000350763.4	-	16	5186	c.4775G>A	c.(4774-4776)gGc>gAc	p.G1592D	TNC_ENST00000345230.3_Intron|TNC_ENST00000481475.1_5'UTR|TNC_ENST00000423613.2_Intron|TNC_ENST00000535648.1_Intron|TNC_ENST00000537320.1_Intron|TNC_ENST00000346706.3_Intron|TNC_ENST00000340094.3_Missense_Mutation_p.G1228D|TNC_ENST00000542877.1_Intron|TNC_ENST00000341037.4_Intron	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1592	Fibronectin type-III 11.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding	p.G1592D(1)		NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						ATAGCCAATGCCAGTTATGAG	0.498000													20	61					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163044731	163044731	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:163044731C>T	ENST00000188790.4	-	20	1969	c.1762G>A	c.(1762-1764)Gtg>Atg	p.V588M	FAP_ENST00000443424.1_Missense_Mutation_p.V563M	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	588					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						TTTCGATACACTGCATAGAGG	0.433000													18	36					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	182941898	182941898	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:182941898G>A	ENST00000328913.3	-	19	2493	c.2196C>T	c.(2194-2196)tgC>tgT	p.C732C	MCF2L2_ENST00000473233.1_Silent_p.C732C	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	732	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CAAAGTAGGCGCAGTCTTGAC	0.393000													72	124					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71197290	71197290	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:71197290C>T	ENST00000554752.2	-	12	3121	c.3122G>A	c.(3121-3123)aGc>aAc	p.S1041N	MAP3K9_ENST00000555993.2_Missense_Mutation_p.S1055N|MAP3K9_ENST00000554146.1_Missense_Mutation_p.S769N|MAP3K9_ENST00000553414.1_Missense_Mutation_p.S774N|MAP3K9_ENST00000381250.4_Missense_Mutation_p.S1018N			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	1041	Ser-rich.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CTCTACAGTGCTGCTACTGCT	0.662000													16	33					0	0	1	0	0
SMCO1	255798	broad.mit.edu	37	3	196236507	196236507	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:196236507C>T	ENST00000397537.2	-	2	240	c.84G>A	c.(82-84)caG>caA	p.Q28Q		NM_001077657.1	NP_001071125.1			single-pass membrane protein with coiled-coil domains 1																		GTTCTTTGAACTGTGTTTCTA	0.413000													25	34					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44260380	44260380	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:44260380C>T	ENST00000315087.7	-	7	1416	c.756G>A	c.(754-756)acG>acA	p.T252T	ST8SIA5_ENST00000536490.1_Silent_p.T221T|ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000538168.1_Silent_p.T288T	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	252					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						CGGTGTTGCGCGTGTTGTAGA	0.587000													5	19					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23219423	23219423	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:23219423C>T	ENST00000400191.3	+	7	1493	c.1475C>T	c.(1474-1476)aCg>aTg	p.T492M	EPHB2_ENST00000374630.3_Missense_Mutation_p.T492M|EPHB2_ENST00000465676.1_3'UTR|EPHB2_ENST00000374632.3_Missense_Mutation_p.T492M|EPHB2_ENST00000374627.1_Missense_Mutation_p.T487M	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	492	Fibronectin type-III 2.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CCCACCAACACGGTCACCGTG	0.577000													3	29					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331557	70331557	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:70331557G>A	ENST00000338508.4	-	32	4843	c.4844C>T	c.(4843-4845)cCg>cTg	p.P1615L	SHANK2_ENST00000423696.2_Missense_Mutation_p.P1235L|SHANK2_ENST00000449833.2_Missense_Mutation_p.P1019L|SHANK2_ENST00000409161.1_Missense_Mutation_p.P1018L			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1235					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGAGAGAATCGGGCTTTTGAT	0.567000													38	55					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85547499	85547499	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:85547499C>T	ENST00000393217.2	+	22	4661	c.4600C>T	c.(4600-4602)Cta>Tta	p.L1534L		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1534										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		AAAGAGTTTGCTAAAATCTGA	0.303000													10	23					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82333770	82333770	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:82333770G>A	ENST00000376520.4	+	16	2398	c.1570G>A	c.(1570-1572)Gcg>Acg	p.A524T	TLE4_ENST00000376552.2_Missense_Mutation_p.A492T|TLE4_ENST00000376537.4_Missense_Mutation_p.A524T|TLE4_ENST00000265284.6_Missense_Mutation_p.A467T|TLE4_ENST00000376534.4_Missense_Mutation_p.A129T|TLE4_ENST00000376544.3_Missense_Mutation_p.A423T			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GGTGGTGTGCGCGGTGACCAT	0.622000													22	41					0	0	1	0	0
TROVE2	6738	broad.mit.edu	37	1	193045659	193045659	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:193045659C>T	ENST00000432079.1	+	3	573	c.5C>T	c.(4-6)cCg>cTg	p.P2L	TROVE2_ENST00000367446.3_Missense_Mutation_p.P277L|TROVE2_ENST00000460715.2_3'UTR|TROVE2_ENST00000367445.3_Missense_Mutation_p.P277L|TROVE2_ENST00000367441.1_Missense_Mutation_p.P277L|TROVE2_ENST00000367444.3_Missense_Mutation_p.P277L|TROVE2_ENST00000400968.2_Missense_Mutation_p.P277L|TROVE2_ENST00000367443.1_Missense_Mutation_p.P277L|TROVE2_ENST00000416058.2_Missense_Mutation_p.P2L			P10155	RO60_HUMAN	TROVE domain family, member 2	277					transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						CAAGAAATGCCGCTTACTGCA	0.328000													48	101					0	0	1	0	0
NUTF2	10204	broad.mit.edu	37	16	67899124	67899124	+	Missense_Mutation	SNP	G	G	A	rs146730920		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67899124G>A	ENST00000219169.4	+	2	374	c.91G>A	c.(91-93)Gca>Aca	p.A31T	NUTF2_ENST00000569436.2_Missense_Mutation_p.A31T|NUTF2_ENST00000568396.2_Missense_Mutation_p.A31T	NM_005796.1	NP_005787.1	P61970	NTF2_HUMAN	nuclear transport factor 2	31	NTF2.				protein transport	cytosol|nuclear pore	protein binding|transporter activity	p.A31P(1)		kidney(1)|lung(2)|upper_aerodigestive_tract(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00443)|Epithelial(162;0.0199)|all cancers(182;0.129)		CCAACTAGGCGCAATTTACGT	0.468000													14	22					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102740674	102740674	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:102740674A>G	ENST00000210633.3	+	12	1641	c.1563A>G	c.(1561-1563)cgA>cgG	p.R521R	SEMA4G_ENST00000370250.4_Silent_p.R521R|MRPL43_ENST00000370241.3_Intron|MRPL43_ENST00000370242.4_Intron|MRPL43_ENST00000318325.2_Intron|RP11-108L7.4_ENST00000447344.1_RNA|SEMA4G_ENST00000517724.1_Silent_p.R521R			Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	521	PSI.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		TCTTGGCCCGAGACCCCTACT	0.642000													38	65					0	0	1	0	0
MLNR	2862	broad.mit.edu	37	13	49795157	49795157	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:49795157G>A	ENST00000398307.1	+	1	684	c.684G>A	c.(682-684)gcG>gcA	p.A228A	MLNR_ENST00000218721.1_Silent_p.A228A			O43193	MTLR_HUMAN	motilin receptor	228					digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity			endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)	14		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		CGGAGGCCGCGGCGCTGTTCA	0.746000													6	29					0	0	1	0	0
RAD51B	5890	broad.mit.edu	37	14	68301821	68301821	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:68301821T>C	ENST00000487270.1	+	4	271	c.223T>C	c.(223-225)Tct>Cct	p.S75P	RAD51B_ENST00000488612.1_Missense_Mutation_p.S75P|RAD51B_ENST00000487861.1_Missense_Mutation_p.S75P|RAD51B_ENST00000390683.3_Missense_Mutation_p.S75P|RAD51B_ENST00000471583.1_Missense_Mutation_p.S75P	NM_133509.3	NP_598193.2	O15315	RA51B_HUMAN	RAD51 paralog B	75					blood coagulation|DNA repair|reciprocal meiotic recombination	nucleoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity		HMGA2/RAD51B(11)	breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11						AGCACAAAGGTCTGCTGATTT	0.378000								Direct reversal of damage					19	30					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18254429	18254429	+	Silent	SNP	G	G	A	rs149105221		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:18254429G>A	ENST00000377369.2	+	4	834	c.561G>A	c.(559-561)acG>acA	p.T187T	SLC39A12_ENST00000539911.1_Silent_p.T53T|SLC39A12_ENST00000377371.3_Silent_p.T187T|SLC39A12_ENST00000377374.4_Silent_p.T187T	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	187					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						AAACCAAAACGCTGCAGAAAA	0.378000													18	37					0	0	1	0	0
FAM83G	644815	broad.mit.edu	37	17	18874781	18874781	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18874781G>A	ENST00000388995.6	-	6	2586	c.2363C>T	c.(2362-2364)tCc>tTc	p.S788F	SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000417251.2_Intron|FAM83G_ENST00000345041.4_Missense_Mutation_p.S788F|SLC5A10_ENST00000395642.1_Intron|SLC5A10_ENST00000317977.6_Intron|SLC5A10_ENST00000395643.2_Intron|SLC5A10_ENST00000395647.2_Intron|FAM83G_ENST00000585154.2_Missense_Mutation_p.S788F			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	788										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						AGACAGTTTGGAGTATGGGAT	0.627000													12	97					0	0	1	0	0
ZNF791	163049	broad.mit.edu	37	19	12738675	12738675	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12738675G>A	ENST00000343325.4	+	4	494	c.332G>A	c.(331-333)cGt>cAt	p.R111H	ZNF791_ENST00000458122.3_Missense_Mutation_p.R79H|ZNF490_ENST00000465656.1_Intron|ZNF791_ENST00000446165.1_3'UTR|ZNF791_ENST00000540038.1_Missense_Mutation_p.R2H	NM_153358.2	NP_699189.2	Q3KP31	ZN791_HUMAN	zinc finger protein 791	111					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)	19						GCCTTCATGCGTCTCTCATCC	0.428000													50	93					0	0	1	0	0
DMWD	1762	broad.mit.edu	37	19	46289586	46289586	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46289586C>T	ENST00000270223.6	-	3	1213	c.1168G>A	c.(1168-1170)Gcc>Acc	p.A390T	DMWD_ENST00000377735.3_Missense_Mutation_p.A390T	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	390					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		TCAGCACCGGCTGCTGTCGCC	0.711000													10	58					0	0	1	0	0
GPR45	11250	broad.mit.edu	37	2	105858891	105858891	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:105858891C>T	ENST00000258456.1	+	1	692	c.576C>T	c.(574-576)gaC>gaT	p.D192D		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	192						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						TCCCCGCTGACCGCGCCTACG	0.682000													9	15					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118770809	118770809	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118770809G>A	ENST00000334801.3	-	7	4187	c.3223C>T	c.(3223-3225)Cca>Tca	p.P1075S	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	1075	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GTGGGGTCTGGGGAGGAAGTG	0.632000													28	46					0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155935172	155935172	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155935172G>A	ENST00000368316.1	-	10	891	c.421C>T	c.(421-423)Cgc>Tgc	p.R141C	ARHGEF2_ENST00000361247.4_Missense_Mutation_p.R168C|ARHGEF2_ENST00000368315.3_Missense_Mutation_p.R169C|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.R168C|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.R141C			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	168					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					AGGATCCGGCGCAGCCCCAGG	0.582000													12	18					0	0	1	0	0
RHOBTB2	23221	broad.mit.edu	37	8	22872264	22872264	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22872264C>T	ENST00000251822.6	+	8	2370	c.1833C>T	c.(1831-1833)gaC>gaT	p.D611D	RP11-875O11.1_ENST00000502083.2_RNA|RHOBTB2_ENST00000519685.1_Silent_p.D633D|RHOBTB2_ENST00000522948.1_Silent_p.D618D	NM_015178.2	NP_055993.2	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2	611					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	31		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		TCGATGGGGACGTCCTTGTGT	0.547000											OREG0018629	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	8					0	0	1	0	0
DHRSX	207063	broad.mit.edu	37	X	2161198	2161198	+	Missense_Mutation	SNP	G	G	A	rs142525989	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:2161198G>A	ENST00000334651.5	-	6	722	c.670C>T	c.(670-672)Cgg>Tgg	p.R224W		NM_145177.2	NP_660160.2	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	224							binding|oxidoreductase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)	16		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GCCAGCAGCCGCTGGAGGTGG	0.642000													14	34					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38790793	38790793	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:38790793C>T	ENST00000359357.3	+	25	3306	c.3052C>T	c.(3052-3054)Cgc>Tgc	p.R1018C	DNAH8_ENST00000449981.2_Missense_Mutation_p.R1235C|DNAH8_ENST00000441566.1_Missense_Mutation_p.R1018C					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GACAGAGGACCGCGATGTGAA	0.458000													21	15					0	0	1	0	0
SIN3A	25942	broad.mit.edu	37	15	75722710	75722710	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75722710G>A	ENST00000394947.3	-	2	321	c.7C>T	c.(7-9)Cgg>Tgg	p.R3W	SIN3A_ENST00000567289.1_Missense_Mutation_p.R3W|SIN3A_ENST00000360439.4_Missense_Mutation_p.R3W|SIN3A_ENST00000394949.4_Missense_Mutation_p.R3W	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	3					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						TCCAAACGCCGCTTCATTCTG	0.547000													3	5					0	0	1	0	0
HNMT	3176	broad.mit.edu	37	2	138759638	138759638	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:138759638T>C	ENST00000280097.3	+	4	485	c.303T>C	c.(301-303)ctT>ctC	p.L101L	HNMT_ENST00000485653.1_3'UTR|HNMT_ENST00000410115.1_Silent_p.L101L	NM_006895.2	NP_008826.1	P50135	HNMT_HUMAN	histamine N-methyltransferase	101					respiratory gaseous exchange	cytoplasm	histamine N-methyltransferase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.125)	Amodiaquine(DB00613)|Histamine Phosphate(DB00667)|Quinacrine(DB01103)	TTTTAGAGCTTGTAGCCAAGA	0.353000													23	28					0	0	1	0	0
KLHL24	54800	broad.mit.edu	37	3	183368576	183368576	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:183368576C>T	ENST00000454652.1	+	4	818	c.432C>T	c.(430-432)agC>agT	p.S144S	KLHL24_ENST00000476808.1_Silent_p.S144S|KLHL24_ENST00000242810.6_Silent_p.S144S			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	144						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			AGACATCAAGCCTCTTTCAGA	0.408000													4	107					0	0	1	0	0
MINA	84864	broad.mit.edu	37	3	97664085	97664085	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:97664085C>A	ENST00000333396.6	-	10	1923	c.1341G>T	c.(1339-1341)gaG>gaT	p.E447D	MINA_ENST00000394198.2_Missense_Mutation_p.E447D|MINA_ENST00000360258.4_Missense_Mutation_p.E446D	NM_001042533.2|NM_032778.5	NP_001035998.1|NP_116167.3	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen	447					ribosome biogenesis	cytoplasm|nucleolus				breast(2)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)	13						TTTCCTTTTCCTCATCTGTAG	0.383000													26	60					7.76418e-22	8.6294e-22	1	1	0
MAPK13	5603	broad.mit.edu	37	6	36106713	36106713	+	Missense_Mutation	SNP	C	C	T	rs138408572		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:36106713C>T	ENST00000211287.4	+	11	1161	c.899C>T	c.(898-900)gCg>gTg	p.A300V	MAPK13_ENST00000373759.1_3'UTR|MAPK13_ENST00000373766.5_Silent_p.R249R|MAPK13_ENST00000373761.6_Missense_Mutation_p.A290V	NM_002754.4	NP_002745.1	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	300	Protein kinase.		A -> T (in dbSNP:rs41270090).		cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|prostate(2)|skin(1)	12						CTGACGGCCGCGCAGGCCCTC	0.617000													5	19					0	0	1	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59941425	59941425	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:59941425G>A	ENST00000265036.5	-	4	539	c.472C>T	c.(472-474)Cgt>Tgt	p.R158C	DEPDC1B_ENST00000545085.1_Missense_Mutation_p.R131C|DEPDC1B_ENST00000453022.2_Missense_Mutation_p.R158C	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	158					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity	p.R158G(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				ATACTGTGACGCTTGTACCAC	0.453000													6	28					0	0	1	0	0
SLC35D3	340146	broad.mit.edu	37	6	137245294	137245294	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:137245294C>T	ENST00000331858.4	+	2	876	c.711C>T	c.(709-711)tgC>tgT	p.C237C		NM_001008783.1	NP_001008783.1	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	237					carbohydrate transport	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	13	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		TGATCGGCTGCGCCATGAACT	0.627000													7	8					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60889421	60889421	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:60889421G>A	ENST00000252999.3	-	62	8509	c.8443C>T	c.(8443-8445)Cct>Tct	p.P2815S		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2815	Laminin G-like 1.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGACTGCAGGGCCCGCCTCA	0.617000													9	22					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144946858	144946858	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144946858C>T	ENST00000525985.1	-	2	635	c.564G>A	c.(562-564)ctG>ctA	p.L188L				P58107	EPIPL_HUMAN	epiplakin 1	188						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CAAGCTCTGACAGCTTGTGCC	0.677000													6	15					0	0	1	0	0
TSPAN32	10077	broad.mit.edu	37	11	2324133	2324133	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:2324133T>C	ENST00000182290.4	+	2	263	c.126T>C	c.(124-126)gcT>gcC	p.A42A	TSPAN32_ENST00000483227.1_3'UTR|TSPAN32_ENST00000451520.2_Silent_p.A31A|TSPAN32_ENST00000381121.3_Silent_p.A42A	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	42					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		CCCACTTTGCTGTCATCCGCC	0.632000													11	20					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184567775	184567775	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:184567775G>A	ENST00000287546.4	+	9	889	c.718G>A	c.(718-720)Gct>Act	p.A240T	VPS8_ENST00000446204.2_Missense_Mutation_p.A238T|VPS8_ENST00000436792.2_Missense_Mutation_p.A238T|VPS8_ENST00000437079.3_Missense_Mutation_p.A240T	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	240							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			AATAACAGATGCTCATCCTCC	0.308000													11	24					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39341247	39341247	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:39341247C>T	ENST00000263408.4	-	4	572		c.e4+1		C9_ENST00000509186.1_Splice_Site	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9						complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			AAAATACACACCCATAGCCTG	0.453000													14	34					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587769	43587769	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:43587769C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GATGAGGTAACTTTTTTGAAG	0.368000													10	8					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23687439	23687439	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:23687439G>A	ENST00000546136.1	-	14	1969	c.1967C>T	c.(1966-1968)cCc>cTc	p.P656L	SOX5_ENST00000545921.1_Missense_Mutation_p.P659L|SOX5_ENST00000381381.2_Missense_Mutation_p.P548L|SOX5_ENST00000451604.2_Missense_Mutation_p.P669L|SOX5_ENST00000541536.1_Missense_Mutation_p.P548L|SOX5_ENST00000537393.1_Missense_Mutation_p.P634L|SOX5_ENST00000396007.2_Missense_Mutation_p.P283L|SOX5_ENST00000309359.1_Missense_Mutation_p.P656L			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	669					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						AGTGGCAATGGGGATCTGTGC	0.502000													4	15					0	0	1	0	0
PCDHGA1	0	broad.mit.edu	37	5	140710637	140710637	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140710637A>G	ENST00000517417.1	+	1	386	c.386A>G	c.(385-387)aAc>aGc	p.N129S	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.N129S	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTAATGACAACACTCCCCAA	0.398000													43	93					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240009300	240009300	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:240009300G>T	ENST00000345617.3	-	19	3175	c.2384C>A	c.(2383-2385)gCt>gAt	p.A795D	HDAC4_ENST00000543185.1_Missense_Mutation_p.A379D	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	795	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GCGGACCACAGCAAAGCCATT	0.582000													11	11					4.7546e-09	5.0353e-09	1	1	0
VPS13B	157680	broad.mit.edu	37	8	100523416	100523416	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:100523416C>T	ENST00000358544.2	+	29	4495	c.4384C>T	c.(4384-4386)Cgc>Tgc	p.R1462C	VPS13B_ENST00000357162.2_Missense_Mutation_p.R1437C|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1462					protein transport			p.R1462S(1)|p.R1437S(1)		NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAAAAATGTCCGCCACAAGTT	0.378000													21	55					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235951390	235951390	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:235951390T>C	ENST00000409212.1	+	4	2484	c.1977T>C	c.(1975-1977)ggT>ggC	p.G659G	SH3BP4_ENST00000344528.4_Silent_p.G659G|SH3BP4_ENST00000392011.2_Silent_p.G659G			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	659					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		TCAAGTTTGGTAAGTTGCTCA	0.567000													11	33					0	0	1	0	0
HAGH	3029	broad.mit.edu	37	16	1873023	1873023	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1873023C>T	ENST00000397356.3	-	2	498	c.92G>A	c.(91-93)gGa>gAa	p.G31E	HAGH_ENST00000397353.2_5'UTR|HAGH_ENST00000566709.1_5'UTR|HAGH_ENST00000455446.2_Missense_Mutation_p.G31E	NM_005326.4	NP_005317.2	Q16775	GLO2_HUMAN	hydroxyacylglutathione hydrolase	31					glutathione biosynthetic process	cytoplasm|mitochondrial matrix	hydroxyacylglutathione hydrolase activity|zinc ion binding			kidney(2)|lung(1)|ovary(1)|skin(1)	5		Hepatocellular(780;0.00335)			Glutathione(DB00143)	GCAGAAAACTCCCAGCAGGGC	0.612000													27	27					0	0	1	0	0
SMG9	56006	broad.mit.edu	37	19	44241781	44241781	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44241781G>A	ENST00000601170.1	-	9	1277	c.963C>T	c.(961-963)gtC>gtT	p.V321V	SMG9_ENST00000270066.6_Silent_p.V321V			Q9H0W8	SMG9_HUMAN	SMG9 nonsense mediated mRNA decay factor	321					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding			kidney(1)|large_intestine(5)|liver(1)|lung(7)|pancreas(1)|prostate(2)|urinary_tract(2)	19						ACCAGTCCTGGACAACAATCA	0.572000													10	26					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37170174	37170174	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:37170174G>A	ENST00000274258.7	-	33	6658	c.3071C>T	c.(3070-3072)cCa>cTa	p.P1024L	C5orf42_ENST00000508244.1_Missense_Mutation_p.P2144L|C5orf42_ENST00000425232.2_Missense_Mutation_p.P2144L			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2144										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TTGACCAGATGGGATAGTTCC	0.443000													72	93					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113172662	113172662	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:113172662C>T	ENST00000295872.4	-	14	2052	c.1793G>A	c.(1792-1794)cGt>cAt	p.R598H		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	598					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						AGTGAAGAGACGATTCTCTTC	0.428000													10	60					0	0	1	0	0
NAPRT1	93100	broad.mit.edu	37	8	144659250	144659250	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144659250G>A	ENST00000449291.2	-	5	960	c.666C>T	c.(664-666)agC>agT	p.S222S	NAPRT1_ENST00000276844.7_Silent_p.S222S|NAPRT1_ENST00000435154.3_Silent_p.S222S|RP11-661A12.9_ENST00000531730.1_RNA|NAPRT1_ENST00000426292.3_Silent_p.S222S			Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain containing 1	222					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			endometrium(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	6	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GGGGCACCTCGCTGCCTGAAA	0.672000													13	13					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32196527	32196527	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32196527G>T	ENST00000373658.3	-	29	4595	c.4254C>A	c.(4252-4254)ccC>ccA	p.P1418P	BAI2_ENST00000398538.1_Silent_p.P1406P|BAI2_ENST00000527361.1_Silent_p.P1385P|BAI2_ENST00000373655.2_Silent_p.P1418P|BAI2_ENST00000398542.1_Silent_p.P1318P|BAI2_ENST00000440175.2_Silent_p.P1027P|BAI2_ENST00000398556.3_Silent_p.P1333P|BAI2_ENST00000465256.1_5'UTR|BAI2_ENST00000398547.1_Silent_p.P1351P|BAI2_ENST00000257070.4_Silent_p.P1385P	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	1418					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TCATTCCATAGGGATTCTGGA	0.677000													11	33					2.32078e-09	2.46314e-09	1	1	0
TAP2	6891	broad.mit.edu	37	6	32805627	32805627	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32805627C>T	ENST00000374897.2	-	2	515	c.384G>A	c.(382-384)gaG>gaA	p.E128E	TAP2_ENST00000452392.2_Silent_p.E128E|TAP2_ENST00000374899.4_Silent_p.E128E	NM_000544.3	NP_000535.3	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	128					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										CCTGGTCCTGCTCCTTCTCCT	0.622000													6	50					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65401666	65401666	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65401666G>A	ENST00000355703.3	+	28	5079	c.4540G>A	c.(4540-4542)Gcc>Acc	p.A1514T	PCNXL3_ENST00000531280.1_3'UTR	NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1514						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CATCACGGCAGCCCTGAGGCC	0.647000													6	6					0	0	1	0	0
PCDHGB3	0	broad.mit.edu	37	5	140750264	140750264	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140750264G>A	ENST00000576222.1	+	1	434	c.303G>A	c.(301-303)acG>acA	p.T101T	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAGTCGACGTGTGTTCTGG	0.433000													5	186					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	10989172	10989172	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:10989172C>A	ENST00000324288.8	+	2	219	c.86C>A	c.(85-87)cCc>cAc	p.P29H	CIITA_ENST00000537380.1_3'UTR|CIITA_ENST00000381835.5_Missense_Mutation_p.P29H	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	29					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						GAGTTGGGGCCCCTAGAAGGT	0.542000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								11	25					7.03913e-09	7.44699e-09	1	1	0
ABCA13	154664	broad.mit.edu	37	7	48314266	48314266	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:48314266G>A	ENST00000435803.1	+	17	5027	c.5003G>A	c.(5002-5004)cGt>cAt	p.R1668H		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1668					transport	integral to membrane	ATP binding|ATPase activity	p.R1668H(1)|p.R1613H(1)		breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCTGTCATGCGTACCCTTAAG	0.388000													44	60					0	0	1	0	0
SLC25A37	51312	broad.mit.edu	37	8	23429210	23429210	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:23429210C>T	ENST00000519973.1	+	4	1057	c.859C>T	c.(859-861)Cgg>Tgg	p.R287W		NM_016612.2	NP_057696.2	Q9NYZ2	MFRN1_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 37	287					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				NS(1)|endometrium(3)|large_intestine(2)|lung(8)|urinary_tract(1)	15		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)		CAATGCCTTCCGGACGGTGTA	0.607000													14	21					0	0	1	0	0
GRIN2A	0	broad.mit.edu	37	16	9858384	9858384	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:9858384G>A	ENST00000396573.2	-	14	3326	c.3017C>T	c.(3016-3018)gCg>gTg	p.A1006V	GRIN2A_ENST00000330684.3_Missense_Mutation_p.A1006V|GRIN2A_ENST00000535259.1_Missense_Mutation_p.A849V|GRIN2A_ENST00000562109.1_Missense_Mutation_p.A1006V|GRIN2A_ENST00000404927.2_Missense_Mutation_p.A1006V|GRIN2A_ENST00000396575.2_Missense_Mutation_p.A1006V	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1006					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCTAGAGTTCGCTTTGGATTC	0.507000													29	40					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204966414	204966414	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:204966414G>A	ENST00000367172.4	+	27	3548	c.3220G>A	c.(3220-3222)Gca>Aca	p.A1074T	NFASC_ENST00000513543.1_Intron|NFASC_ENST00000338515.6_Missense_Mutation_p.A1074T|NFASC_ENST00000404076.1_Intron|NFASC_ENST00000367169.4_Intron|NFASC_ENST00000539706.1_Intron|NFASC_ENST00000495396.1_Intron|NFASC_ENST00000367171.4_Missense_Mutation_p.A1059T|NFASC_ENST00000360049.4_Intron|NFASC_ENST00000339876.6_Missense_Mutation_p.A967T|NFASC_ENST00000367170.4_Intron|NFASC_ENST00000401399.1_Missense_Mutation_p.A967T|NFASC_ENST00000404907.1_Intron|NFASC_ENST00000338586.6_Intron			O94856	NFASC_HUMAN	neurofascin	1074	Thr-rich.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCCAACTGTCGCACCTaccac	0.637000													8	3					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36271177	36271177	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36271177C>T	ENST00000007510.4	+	7	710	c.566C>T	c.(565-567)gCg>gTg	p.A189V	ARHGAP33_ENST00000314737.5_Missense_Mutation_p.A189V|ARHGAP33_ENST00000378944.5_Missense_Mutation_p.A53V			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	189	SH3.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding	p.A189V(1)		endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CCTGCAGTGGCGGCCGCCCAT	0.592000													27	18					0	0	1	0	0
CECR5	27440	broad.mit.edu	37	22	17619480	17619480	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:17619480G>A	ENST00000336737.4	-	7	920	c.895C>T	c.(895-897)Cgg>Tgg	p.R299W	CECR5_ENST00000399852.3_Intron|CECR5_ENST00000155674.5_Missense_Mutation_p.R269W	NM_033070.2	NP_149061.1	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	299							hydrolase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(10)|pancreas(1)|prostate(1)	21		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				GCCCAGCCCCGCCTCTCCGCC	0.612000													47	77					0	0	1	0	0
TUBAL3	79861	broad.mit.edu	37	10	5436177	5436177	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:5436177G>A	ENST00000380419.3	-	4	681	c.644C>T	c.(643-645)gCc>gTc	p.A215V	TUBAL3_ENST00000479328.1_Missense_Mutation_p.A175V	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	215					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						ATCATAGACGGCCTCGTTGTC	0.522000													13	19					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196799426	196799426	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:196799426G>A	ENST00000312428.6	-	21	3460	c.3360C>T	c.(3358-3360)agC>agT	p.S1120S		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1120	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CCTCTCCTTCGCTGCTCTTCA	0.398000													43	70					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57347138	57347138	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:57347138A>T	ENST00000361249.3	+	5	581	c.485A>T	c.(484-486)gAa>gTa	p.E162V		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	162	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CTGACCCAGGAAGATGCTCAG	0.458000													30	48					0	0	1	0	0
MYOT	9499	broad.mit.edu	37	5	137217729	137217729	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137217729C>T	ENST00000239926.4	+	6	1125	c.751C>T	c.(751-753)Cgt>Tgt	p.R251C	MYOT_ENST00000421631.2_Missense_Mutation_p.R67C|RP11-381K20.2_ENST00000514616.1_RNA|MYOT_ENST00000515645.1_Missense_Mutation_p.R136C|MYOT_ENST00000509812.1_Intron	NM_006790.2	NP_006781.1	Q9UBF9	MYOTI_HUMAN	myotilin	251	Ig-like C2-type 1.|Necessary for interaction with ACTA1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle	p.R251S(1)		cervix(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTACCCACCACGTTTCATTCA	0.398000													23	31					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31025073	31025073	+	Missense_Mutation	SNP	G	G	A	rs146743741		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31025073G>A	ENST00000375687.4	+	13	4982	c.4558G>A	c.(4558-4560)Ggt>Agt	p.G1520S	ASXL1_ENST00000306058.5_Missense_Mutation_p.G1515S	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	1520					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						CCAAGGCTGCGGTGCGTTCTG	0.473000			"""F, N, Mis"""		"""MDS, CMML"""								46	58					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52430755	52430755	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52430755G>A	ENST00000420323.2	+	72	11813	c.11552G>A	c.(11551-11553)cGc>cAc	p.R3851H		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3916	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGAGATCTGCGCATCTGCATC	0.577000													9	126					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71495575	71495575	+	Silent	SNP	G	G	A	rs149330290		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:71495575G>A	ENST00000296755.7	+	5	6691	c.6393G>A	c.(6391-6393)ccG>ccA	p.P2131P		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2131						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GAGCCCCACCGCCTCCAGGAG	0.567000													24	34					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168099595	168099595	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:168099595G>A	ENST00000409195.1	+	9	1782	c.1693G>A	c.(1693-1695)Gaa>Aaa	p.E565K	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E565K|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.E343K|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	390					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGAATACTTGGAATGGGATGA	0.418000													21	28					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57113481	57113481	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57113481A>G	ENST00000454682.1	-	3	2114	c.1833T>C	c.(1831-1833)ccT>ccC	p.P611P	NACA_ENST00000550952.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000552540.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	82					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TAACACCCAGAGGGGAGGTCA	0.517000			T	BCL6	NHL								16	17					0	0	1	0	0
XPO5	57510	broad.mit.edu	37	6	43540301	43540301	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43540301C>A	ENST00000265351.7	-	3	452	c.242G>T	c.(241-243)gGc>gTc	p.G81V		NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	81	Necessary for interaction with Ran.			G -> S (in Ref. 1; AAG53603).	gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			TCGAGACATGCCGTTCCACCG	0.408000													26	30					1.26454e-06	1.31807e-06	1	1	0
ATP11A	23250	broad.mit.edu	37	13	113479755	113479755	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113479755C>T	ENST00000487903.1	+	11	972	c.884C>T	c.(883-885)gCg>gTg	p.A295V	ATP11A_ENST00000375630.2_Missense_Mutation_p.A295V|ATP11A_ENST00000283558.8_Missense_Mutation_p.A295V|ATP11A_ENST00000375645.3_Missense_Mutation_p.A295V			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	295					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TCGATGAATGCGTTCCTCATT	0.473000													22	41					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28602420	28602420	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:28602420G>A	ENST00000434452.1	-	7	978	c.824C>T	c.(823-825)aCa>aTa	p.T275I	DSC3_ENST00000360428.4_Missense_Mutation_p.T275I	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	275	Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CGTATGCATTGTGTCCGGTTC	0.443000													40	49					0	0	1	0	0
NAA16	79612	broad.mit.edu	37	13	41947883	41947883	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:41947883C>T	ENST00000379406.3	+	18	2590	c.2266C>T	c.(2266-2268)Cgt>Tgt	p.R756C	NAA16_ENST00000497143.1_3'UTR	NM_024561.4	NP_078837.3	Q6N069	NAA16_HUMAN	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	756					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|urinary_tract(2)	31						TTTTCTGAAACGTAACGCTAC	0.363000													34	56					0	0	1	0	0
USP15	9958	broad.mit.edu	37	12	62749197	62749197	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:62749197C>T	ENST00000280377.5	+	8	914	c.856C>T	c.(856-858)Cca>Tca	p.P286S	USP15_ENST00000353364.3_Missense_Mutation_p.P257S|USP15_ENST00000393654.3_Missense_Mutation_p.P261S	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	286					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		CAATGAACAGCCAGGCCTCTG	0.368000													8	34					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55204233	55204233	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:55204233G>T	ENST00000396834.1	+	13	1934	c.1438G>T	c.(1438-1440)Gga>Tga	p.G480*	IL31RA_ENST00000396836.2_Nonsense_Mutation_p.G499*|IL31RA_ENST00000354961.4_Nonsense_Mutation_p.G480*|IL31RA_ENST00000359040.5_Nonsense_Mutation_p.G499*|IL31RA_ENST00000297015.3_Nonsense_Mutation_p.G357*|IL31RA_ENST00000490985.1_Nonsense_Mutation_p.G357*|IL31RA_ENST00000447346.2_Nonsense_Mutation_p.G499*	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	467	Fibronectin type-III 5.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				AGGTGGAAAAGGATTCTGTAA	0.478000													18	29					2.94398e-08	3.10271e-08	1	1	0
FABP6	2172	broad.mit.edu	37	5	159665625	159665625	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:159665625G>A	ENST00000393980.4	+	7	639	c.493G>A	c.(493-495)Gga>Aga	p.G165R	FABP6_ENST00000393982.1_Missense_Mutation_p.G165R|FABP6_ENST00000402432.3_Missense_Mutation_p.G116R	NM_001130958.1	NP_001124430.1	P51161	FABP6_HUMAN	fatty acid binding protein 6, ileal	116					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCCACCATCGGAGGCGTGAC	0.587000													16	42					0	0	1	0	0
FAM24A	118670	broad.mit.edu	37	10	124671241	124671241	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:124671241T>C	ENST00000368894.1	+	2	212	c.91T>C	c.(91-93)Ttc>Ctc	p.F31L		NM_001029888.1	NP_001025059.1	A6NFZ4	FA24A_HUMAN	family with sequence similarity 24, member A	31						extracellular region				large_intestine(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	9		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.124)|COAD - Colon adenocarcinoma(40;0.141)		AAGTGTTGTGTTCTGTCTTTA	0.468000													9	228					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116358026	116358026	+	Missense_Mutation	SNP	C	C	T	rs144334750		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:116358026C>T	ENST00000374140.2	+	25	3601	c.3392C>T	c.(3391-3393)gCg>gTg	p.A1131V	RGS3_ENST00000343817.5_Missense_Mutation_p.A850V|RGS3_ENST00000394646.3_Missense_Mutation_p.A524V|RGS3_ENST00000462403.1_Missense_Mutation_p.A244V|RGS3_ENST00000342620.5_Missense_Mutation_p.A101V|RGS3_ENST00000462143.1_Missense_Mutation_p.A452V|RGS3_ENST00000374134.3_Missense_Mutation_p.A452V|RGS3_ENST00000350696.5_Missense_Mutation_p.A1131V	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	1131	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GAATACATCGCGATCCAGGCA	0.567000													15	24					0	0	1	0	0
PYDC1	260434	broad.mit.edu	37	16	31228335	31228335	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31228335G>A	ENST00000302964.3	-	1	345	c.15C>T	c.(13-15)cgC>cgT	p.R5R	TRIM72_ENST00000322122.3_Intron	NM_152901.2	NP_690865.1	Q8WXC3	PYDC1_HUMAN	PYD (pyrin domain) containing 1	5	DAPIN.				innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|positive regulation of interleukin-1 beta secretion|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex|nucleus	cysteine-type endopeptidase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						GGATGGCCTCGCGCTTCGTTC	0.652000													6	10					0	0	1	0	0
PHF7	51533	broad.mit.edu	37	3	52455688	52455688	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52455688C>T	ENST00000327906.3	+	8	1258	c.598C>T	c.(598-600)Cat>Tat	p.H200Y	PHF7_ENST00000478707.1_Missense_Mutation_p.H200Y|PHF7_ENST00000347025.2_Missense_Mutation_p.H200Y	NM_016483.4	NP_057567.3	Q9BWX1	PHF7_HUMAN	PHD finger protein 7	200						nucleus	zinc ion binding			breast(2)|large_intestine(4)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		ATCAGCAAAGCATTTCTTCAA	0.433000													9	40					0	0	1	0	0
NKTR	4820	broad.mit.edu	37	3	42680699	42680699	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:42680699C>T	ENST00000232978.8	+	13	3691	c.3503C>T	c.(3502-3504)aCg>aTg	p.T1168M	RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1168					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GATATGGCAACGGAACATCCT	0.473000													14	14					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62887726	62887726	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:62887726G>T	ENST00000393630.3	+	3	598	c.207G>T	c.(205-207)caG>caT	p.Q69H	MON2_ENST00000280379.6_Missense_Mutation_p.Q69H|MON2_ENST00000552738.1_Missense_Mutation_p.Q69H|MON2_ENST00000552115.1_Missense_Mutation_p.Q69H|MON2_ENST00000393632.2_Missense_Mutation_p.Q69H|MON2_ENST00000549378.1_Intron|MON2_ENST00000546600.1_Missense_Mutation_p.Q69H|MON2_ENST00000393629.2_Missense_Mutation_p.Q69H	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	69					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		AGGTTGTACAGCCTTTTTTAA	0.343000													12	12					1.08611e-07	1.14056e-07	1	1	0
TRAV29DV5	0	broad.mit.edu	37	14	22631699	22631699	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22631699G>T	ENST00000390458.3	+	0	402																											AAAGTGCCAAGCACCTCTCTC	0.478000											OREG0022575	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	12					2.32078e-09	2.46314e-09	1	1	0
CALCOCO2	10241	broad.mit.edu	37	17	46925456	46925456	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:46925456A>G	ENST00000258947.3	+	3	312	c.211A>G	c.(211-213)Acc>Gcc	p.T71A	CALCOCO2_ENST00000509507.1_Missense_Mutation_p.T92A|CALCOCO2_ENST00000416445.2_Missense_Mutation_p.T71A|CALCOCO2_ENST00000448105.2_Missense_Mutation_p.T95A|CALCOCO2_ENST00000508679.1_5'UTR	NM_001261390.1|NM_001261391.1|NM_001261393.1|NM_001261395.1|NM_005831.4	NP_001248319.1|NP_001248320.1|NP_001248322.1|NP_001248324.1|NP_005822.1	Q13137	CACO2_HUMAN	calcium binding and coiled-coil domain 2	71					response to interferon-gamma|viral reproduction	cytoskeleton|Golgi apparatus|nucleus|perinuclear region of cytoplasm|soluble fraction	protein homodimerization activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	15						TGAGTATTACACCTTCATGTG	0.423000													13	25					0	0	1	0	0
ACTN3	89	broad.mit.edu	37	11	66329000	66329000	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66329000G>T	ENST00000513398.1	+	0	2164				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						GGCAGCAGGAGCAGAACATTA	0.597000													6	9					0.0215528	0.0217053	1	1	0
SLC36A1	206358	broad.mit.edu	37	5	150847345	150847345	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150847345G>A	ENST00000243389.3	+	7	805	c.582G>A	c.(580-582)tcG>tcA	p.S194S	SLC36A1_ENST00000429484.2_Silent_p.S194S|SLC36A1_ENST00000520701.1_Silent_p.S194S|SLC36A1_ENST00000521925.1_Silent_p.S194S	NM_078483.2	NP_510968.2	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 1	194					cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			endometrium(5)|kidney(9)|lung(8)|skin(2)|urinary_tract(1)	25		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	CCATGGACTCGCGACTCTACA	0.532000													39	31					0	0	1	0	0
PARVG	64098	broad.mit.edu	37	22	44585032	44585032	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:44585032G>A	ENST00000422871.1	+	6	710	c.286G>A	c.(286-288)Gcc>Acc	p.A96T	PARVG_ENST00000444313.2_Missense_Mutation_p.A96T|PARVG_ENST00000415224.1_Missense_Mutation_p.A96T	NM_001137605.1	NP_001131077.1	Q9HBI0	PARVG_HUMAN	parvin, gamma	96	CH 1.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(10)	17		Ovarian(80;0.024)|all_neural(38;0.0299)				AGAGGACATCGCCCTGACAGC	0.652000													20	32					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901669	51901669	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:51901669C>T	ENST00000268919.4	+	1	1431	c.1275C>T	c.(1273-1275)agC>agT	p.S425S		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	425	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CATCCAGGAGCCATGCAGTGT	0.493000													14	24					0	0	1	0	0
ALG14	199857	broad.mit.edu	37	1	95530491	95530491	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:95530491A>G	ENST00000370205.4	-	2	265	c.219T>C	c.(217-219)acT>acC	p.T73T	RP11-313A24.1_ENST00000451611.1_RNA|ALG14_ENST00000495856.1_5'UTR	NM_144988.3	NP_659425.1	Q96F25	ALG14_HUMAN	ALG14, UDP-N-acetylglucosaminyltransferase subunit	73					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|large_intestine(1)|lung(2)|pancreas(1)	6		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.0615)|Epithelial(280;0.139)		TCATTTCATCAGTGTCAGCAA	0.388000													7	19					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151682934	151682934	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:151682934C>A	ENST00000535741.1	-	35	6119		c.e35+1		LRBA_ENST00000357115.3_Splice_Site|LRBA_ENST00000507224.1_Splice_Site|LRBA_ENST00000510413.1_Splice_Site			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing							endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					aaataaattaCCTTCCTTCAT	0.284000													36	52					6.05902e-23	6.74593e-23	1	1	0
DCST2	127579	broad.mit.edu	37	1	154991112	154991112	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154991112C>T	ENST00000368424.3	-	15	2288	c.2230G>A	c.(2230-2232)Gcc>Acc	p.A744T		NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	744	Pro-rich.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CCTTTAGTGGCGGAGGATGTC	0.587000													15	26					0	0	1	0	0
NTHL1	4913	broad.mit.edu	37	16	2096314	2096314	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2096314G>A	ENST00000219066.1	-	2	211	c.193C>T	c.(193-195)Cgt>Tgt	p.R65C		NM_002528.5	NP_002519.1	P78549	NTHL1_HUMAN	nth endonuclease III-like 1 (E. coli)	65					depyrimidination|nucleotide-excision repair, DNA incision, 5'-to lesion	nucleoplasm	4 iron, 4 sulfur cluster binding|double-stranded DNA binding|endonuclease activity|metal ion binding|oxidized pyrimidine base lesion DNA N-glycosylase activity|protein binding			lung(1)	1						TAGGCCACACGCAGTCTCTGT	0.622000								Base excision repair (BER), DNA glycosylases					27	50					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45867671	45867671	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:45867671C>T	ENST00000311275.7	-	15	2689	c.2436G>A	c.(2434-2436)ccG>ccA	p.P812P	ZMYND8_ENST00000352431.2_Silent_p.P832P|ZMYND8_ENST00000540497.1_Silent_p.P760P|ZMYND8_ENST00000458360.2_Intron|ZMYND8_ENST00000396281.4_Silent_p.P812P|ZMYND8_ENST00000262975.4_Silent_p.P812P|ZMYND8_ENST00000536340.1_Silent_p.P839P|ZMYND8_ENST00000471951.2_Silent_p.P832P|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000355972.4_Silent_p.P812P|ZMYND8_ENST00000372023.3_Silent_p.P807P|ZMYND8_ENST00000360911.3_Silent_p.P807P|ZMYND8_ENST00000461685.1_Silent_p.P832P|ZMYND8_ENST00000446994.2_Silent_p.P749P			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	812							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GCTGCACGGCCGGGGCAGTCT	0.622000													33	54					0	0	1	0	0
YARS2	51067	broad.mit.edu	37	12	32903660	32903660	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:32903660C>T	ENST00000324868.8	-	3	1123	c.1096G>A	c.(1096-1098)Gct>Act	p.A366T		NM_001040436.2	NP_001035526.1	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	366					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	16	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	TACCTTTTAGCAGAATCCAAT	0.403000													13	36					0	0	1	0	0
NARF	26502	broad.mit.edu	37	17	80417915	80417915	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80417915C>T	ENST00000309794.10	+	2	273	c.75C>T	c.(73-75)gcC>gcT	p.A25A	NARF_ENST00000581743.1_3'UTR|NARF_ENST00000412079.2_5'UTR|NARF_ENST00000390006.4_5'UTR|NARF_ENST00000457415.3_Silent_p.A25A|NARF_ENST00000345415.7_Silent_p.A25A	NM_012336.3|NM_031968.2	NP_036468.1|NP_114174.1	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor	25						lamin filament	lamin binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			ATGTGTCAGCCGATGCACCGA	0.408000													19	27					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2962899	2962899	+	Missense_Mutation	SNP	G	G	A	rs3735134		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2962899G>A	ENST00000396946.4	-	16	2412	c.2009C>T	c.(2008-2010)aCg>aTg	p.T670M		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	670	PDZ.		T -> M (in dbSNP:rs3735134).		positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GCCATTCAGCGTCGTGTGCTG	0.657000			Mis		DLBCL								12	30					0	0	1	0	0
KIF20A	10112	broad.mit.edu	37	5	137520619	137520619	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137520619C>T	ENST00000394894.3	+	14	2033	c.1807C>T	c.(1807-1809)Cgg>Tgg	p.R603W	KIF20A_ENST00000508792.1_Missense_Mutation_p.R585W	NM_005733.2	NP_005724.1	O95235	KI20A_HUMAN	kinesin family member 20A	603					cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|liver(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(1)	27			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GATGCAACAGCGGGAACAGTG	0.493000													33	41					0	0	1	0	0
TSSK2	23617	broad.mit.edu	37	22	19119445	19119445	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19119445C>T	ENST00000399635.2	+	1	1125	c.533C>T	c.(532-534)tCg>tTg	p.S178L	DGCR14_ENST00000252137.6_3'UTR	NM_053006.4	NP_443732.3	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	178	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(2)|prostate(4)|stomach(1)	11	Colorectal(54;0.0993)					TTCTGCGGGTCGGCAGCATAT	0.582000													24	60					0	0	1	0	0
NPNT	255743	broad.mit.edu	37	4	106859520	106859520	+	Missense_Mutation	SNP	C	C	T	rs145340246	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:106859520C>T	ENST00000379987.2	+	5	664	c.448C>T	c.(448-450)Cgg>Tgg	p.R150W	NPNT_ENST00000506666.1_Missense_Mutation_p.R180W|NPNT_ENST00000453617.2_Missense_Mutation_p.R167W|NPNT_ENST00000514622.1_Missense_Mutation_p.R150W|NPNT_ENST00000427316.2_Missense_Mutation_p.R180W|NPNT_ENST00000305572.8_Missense_Mutation_p.R150W	NM_001033047.2	NP_001028219.1	Q6UXI9	NPNT_HUMAN	nephronectin	150	EGF-like 3.				cell differentiation	membrane	calcium ion binding			kidney(5)|large_intestine(2)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	21		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		AGGACAAATACGGTGCCAGTG	0.532000													18	37					0	0	1	0	0
NOXRED1	122945	broad.mit.edu	37	14	77861007	77861007	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:77861007C>A	ENST00000380835.2	-	6	1213	c.1047G>T	c.(1045-1047)caG>caT	p.Q349H		NM_001113475.2	NP_001106946.1	Q6NXP6	CN148_HUMAN	NADP-dependent oxidoreductase domain containing 1	349					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9						AAATGACTGGCTGTTCTTTGG	0.433000													18	30					1.37657e-19	1.52335e-19	1	1	0
RNF149	284996	broad.mit.edu	37	2	101911428	101911428	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:101911428G>A	ENST00000295317.3	-	2	783	c.676C>T	c.(676-678)Cgt>Tgt	p.R226C		NM_173647.3	NP_775918.2	Q8NC42	RN149_HUMAN	ring finger protein 149	226						integral to membrane	ligase activity|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	12						TATAGGAAACGCTGTATATAG	0.373000													12	46					0	0	1	0	0
SUPT3H	8464	broad.mit.edu	37	6	44921078	44921078	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:44921078G>A	ENST00000371460.1	-	11	1120	c.803C>T	c.(802-804)gCa>gTa	p.A268V	SUPT3H_ENST00000306867.5_Missense_Mutation_p.A257V|SUPT3H_ENST00000371458.1_Missense_Mutation_p.A40V|SUPT3H_ENST00000371461.2_Missense_Mutation_p.A268V|SUPT3H_ENST00000371459.1_Missense_Mutation_p.A257V	NM_181356.2	NP_852001.1	O75486	SUPT3_HUMAN	suppressor of Ty 3 homolog (S. cerevisiae)	339					histone deubiquitination|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	STAGA complex|transcription factor TFTC complex	DNA binding|transcription coactivator activity			breast(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)	12						AATGAAGGTTGCAGAAATGGC	0.403000													6	12					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58520136	58520136	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58520136G>A	ENST00000302819.5	-	3	565	c.274C>T	c.(274-276)Cgg>Tgg	p.R92W	ACOX2_ENST00000459701.2_Missense_Mutation_p.R92W	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	92					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		CCCAGGCGCCGAGCTATCAAC	0.527000													4	76					0	0	1	0	0
CRAMP1L	57585	broad.mit.edu	37	16	1706079	1706079	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1706079G>A	ENST00000397412.3	+	10	1420	c.1321G>A	c.(1321-1323)Gtg>Atg	p.V441M	CRAMP1L_ENST00000262317.4_Intron|LA16c-431H6.6_ENST00000454337.1_Intron|CRAMP1L_ENST00000436138.3_Missense_Mutation_p.V438M|CRAMP1L_ENST00000293925.5_Missense_Mutation_p.V441M			Q96RY5	CRML_HUMAN	Crm, cramped-like (Drosophila)	441						nucleus	DNA binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)	22						GGACGCCCACGTGCTGCCCCC	0.711000													4	6					0	0	1	0	0
CNTROB	116840	broad.mit.edu	37	17	7842903	7842903	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7842903C>T	ENST00000380262.3	+	8	1925	c.1000C>T	c.(1000-1002)Cgg>Tgg	p.R334W	CNTROB_ENST00000563694.1_Missense_Mutation_p.R334W|CNTROB_ENST00000565740.1_Missense_Mutation_p.R334W|CNTROB_ENST00000380255.3_Missense_Mutation_p.R334W	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	334					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				GCAGGAAGAGCGGGATGCAGC	0.592000													30	54					0	0	1	0	0
CACNG1	786	broad.mit.edu	37	17	65052280	65052280	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:65052280G>A	ENST00000226021.3	+	4	633	c.562G>A	c.(562-564)Gcc>Acc	p.A188T		NM_000727.3	NP_000718.1	Q06432	CCG1_HUMAN	calcium channel, voltage-dependent, gamma subunit 1	188					muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(1)|large_intestine(2)|lung(2)|prostate(1)|skin(2)	8	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	CGCCTGTGCCGCCTTCATCCT	0.607000													14	25					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102494048	102494048	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:102494048C>T	ENST00000360184.4	+	47	9305	c.9141C>T	c.(9139-9141)caC>caT	p.H3047H		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3047	AAA 4 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TGGACTCGCACGAGGAGCTCT	0.572000													4	46					0	0	1	0	0
KLHL31	401265	broad.mit.edu	37	6	53519296	53519296	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:53519296G>A	ENST00000370905.3	-	2	915	c.775C>T	c.(775-777)Cgc>Tgc	p.R259C	KLHL31_ENST00000407079.1_Missense_Mutation_p.R259C	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	259	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					GTACCAAAGCGAATATTGCTC	0.398000													5	113					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6478687	6478687	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:6478687C>T	ENST00000525074.1	-	5	929	c.535G>A	c.(535-537)Gca>Aca	p.A179T	TRIM3_ENST00000537602.1_Missense_Mutation_p.A179T|TRIM3_ENST00000536344.1_Missense_Mutation_p.A60T|TRIM3_ENST00000359518.3_Missense_Mutation_p.A179T|TRIM3_ENST00000345851.3_Missense_Mutation_p.A179T|TRIM3_ENST00000529058.1_5'UTR	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	179					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAGGCAATTGCTGCGGACAGC	0.597000													12	28					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113941078	113941078	+	Missense_Mutation	SNP	G	G	A	rs143845355	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:113941078G>A	ENST00000245796.6	+	2	1240	c.1045G>A	c.(1045-1047)Ggg>Agg	p.G349R	PSD4_ENST00000441564.2_Missense_Mutation_p.G349R	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	349					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TCCTGGTCACGGGGAGAGTGA	0.612000													7	15					0	0	1	0	0
KIF18B	146909	broad.mit.edu	37	17	43006261	43006261	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:43006261G>T	ENST00000587309.1	-	12	1708	c.1685C>A	c.(1684-1686)cCt>cAt	p.P562H	KIF18B_ENST00000438933.2_Missense_Mutation_p.P562H|KIF18B_ENST00000593135.1_Missense_Mutation_p.P550H|KIF18B_ENST00000590129.1_Missense_Mutation_p.P571H|KIF18B_ENST00000339151.4_Missense_Mutation_p.P562H	NM_001264573.1	NP_001251503.1			kinesin family member 18B											breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	21		Prostate(33;0.155)				CTCTGCCCCAGGCTCAATTTT	0.592000													4	17					0.150653	0.151081	1	1	0
HSPH1	10808	broad.mit.edu	37	13	31724105	31724105	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:31724105C>A	ENST00000320027.5	-	8	1467	c.1123G>T	c.(1123-1125)Gga>Tga	p.G375*	HSPH1_ENST00000380406.5_Nonsense_Mutation_p.G334*|HSPH1_ENST00000429785.2_Nonsense_Mutation_p.G194*|HSPH1_ENST00000380405.4_Nonsense_Mutation_p.G375*|HSPH1_ENST00000445273.2_Nonsense_Mutation_p.G377*	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	375					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		AATGCACATCCTCTGGCTACT	0.423000													27	47					8.24728e-16	9.04077e-16	1	1	0
SLC35C1	55343	broad.mit.edu	37	11	45832372	45832372	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:45832372T>C	ENST00000314134.3	+	2	1977	c.581T>C	c.(580-582)cTg>cCg	p.L194P	SLC35C1_ENST00000456334.1_Missense_Mutation_p.L181P|SLC35C1_ENST00000442528.2_Missense_Mutation_p.L181P	NM_018389.4	NP_060859.4	Q96A29	FUCT1_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C1	194						Golgi membrane|integral to membrane	GDP-fucose transmembrane transporter activity			endometrium(3)|kidney(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				GBM - Glioblastoma multiforme(35;0.227)		GAAGGCACCCTGTCGTGGCTG	0.657000													11	19					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84211392	84211392	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:84211392G>A	ENST00000378553.5	+	12	2247	c.2123G>A	c.(2122-2124)aGc>aAc	p.S708N	DNAAF1_ENST00000563818.1_3'UTR	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	708					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						GCCCAGCCCAGCCAAGCTCTG	0.542000													7	49					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27687252	27687252	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:27687252G>A	ENST00000493901.1	-	16	2237	c.1998C>T	c.(1996-1998)cgC>cgT	p.R666R	MAP3K6_ENST00000357582.2_Silent_p.R666R|MAP3K6_ENST00000374040.3_Silent_p.R658R	NM_004672.3	NP_004663.3	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	666	Protein kinase.				activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TGTGGCGATCGCGGCCCGCGT	0.697000													8	16					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44260279	44260279	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:44260279G>A	ENST00000315087.7	-	7	1517	c.857C>T	c.(856-858)tCg>tTg	p.S286L	ST8SIA5_ENST00000536490.1_Missense_Mutation_p.S255L|ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000538168.1_Missense_Mutation_p.S322L	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	286					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						CCAGTAGCGCGACACGTTGAC	0.617000													16	14					0	0	1	0	0
ALKBH4	54784	broad.mit.edu	37	7	102098266	102098266	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:102098266G>A	ENST00000292566.3	-	3	523	c.484C>T	c.(484-486)Cgg>Tgg	p.R162W		NM_017621.3	NP_060091.1	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4 (E. coli)	162						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(1)|lung(5)|skin(2)	8						GCAGAGCCCCGCTCGGGGCAG	0.701000													10	12					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7607506	7607506	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7607506G>A	ENST00000221249.6	+	14	1626	c.1195G>A	c.(1195-1197)Gtg>Atg	p.V399M	PNPLA6_ENST00000414982.3_Missense_Mutation_p.V447M|PNPLA6_ENST00000600737.1_Missense_Mutation_p.V438M|PNPLA6_ENST00000545201.2_Missense_Mutation_p.V399M|PNPLA6_ENST00000450331.3_Missense_Mutation_p.V399M	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	438					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						CCGGATCTCCGTGTCCCTGCA	0.677000													14	19					0	0	1	0	0
G3BP2	9908	broad.mit.edu	37	4	76570792	76570792	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:76570792C>T	ENST00000359707.4	-	12	2056	c.1271G>A	c.(1270-1272)cGc>cAc	p.R424H	G3BP2_ENST00000395719.3_Missense_Mutation_p.R424H|G3BP2_ENST00000357854.3_Missense_Mutation_p.R391H	NM_203505.2	NP_987101.1	Q9UN86	G3BP2_HUMAN	GTPase activating protein (SH3 domain) binding protein 2	424	Gly-rich.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	27			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			AATATCCCTGCGATCATCACC	0.498000													32	22					0	0	1	0	0
NR2C2AP	126382	broad.mit.edu	37	19	19313664	19313664	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19313664G>A	ENST00000331552.6	-	2	428	c.65C>T	c.(64-66)aCt>aTt	p.T22I	NR2C2AP_ENST00000590907.2_Intron|NR2C2AP_ENST00000538165.2_Missense_Mutation_p.T22I|NR2C2AP_ENST00000544883.1_Missense_Mutation_p.T22I|NR2C2AP_ENST00000420605.2_Missense_Mutation_p.T22I	NM_176880.4	NP_795361.1	Q86WQ0	NR2CA_HUMAN	nuclear receptor 2C2-associated protein	22					cell adhesion|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm				breast(1)|cervix(1)|kidney(2)|ovary(1)	5			Epithelial(12;0.00235)			AAACTGCCGAGTGTTGCGATT	0.582000													21	34					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50546791	50546791	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:50546791G>A	ENST00000267845.3	-	5	914	c.512C>T	c.(511-513)aCg>aTg	p.T171M	HDC_ENST00000543581.1_Missense_Mutation_p.T171M	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	171					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	GGGCTCAGACGTTTTCATTTC	0.552000													10	25					0	0	1	0	0
PARM1	25849	broad.mit.edu	37	4	75938008	75938008	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:75938008G>A	ENST00000307428.7	+	2	629	c.417G>A	c.(415-417)tcG>tcA	p.S139S	PARM1_ENST00000513238.1_Intron|RP11-44F21.2_ENST00000513770.1_RNA	NM_015393.3	NP_056208.2	Q6UWI2	PARM1_HUMAN	prostate androgen-regulated mucin-like protein 1	139					positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				cervix(1)|endometrium(2)|lung(4)|ovary(1)	8						CTACACTGTCGCAGTCCGCTG	0.582000													29	55					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163292018	163292018	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:163292018G>A	ENST00000332142.5	-	8	1743	c.1644C>T	c.(1642-1644)ggC>ggT	p.G548G	KCNH7_ENST00000328032.4_Silent_p.G541G	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	548					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	GAACAGCAGCGCCATATTCTG	0.463000													6	15					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10769939	10769939	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:10769939C>A	ENST00000283025.2	-	5	1034	c.963G>T	c.(961-963)gaG>gaT	p.E321D		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	321					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						CAAAGAGGTGCTCCGCCTCCT	0.552000													12	74					4.3838e-07	4.58243e-07	1	1	0
LRIF1	55791	broad.mit.edu	37	1	111494603	111494603	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:111494603C>T	ENST00000369763.4	-	2	1293	c.903G>A	c.(901-903)acG>acA	p.T301T	LRIF1_ENST00000485275.2_Intron|RP11-96K19.2_ENST00000440689.1_RNA|LRIF1_ENST00000494675.1_Intron	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						CAAGAGATGGCGTAAAAGGCT	0.348000													28	39					0	0	1	0	0
GPR113	165082	broad.mit.edu	37	2	26539917	26539917	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:26539917G>A	ENST00000333478.6	-	3	770	c.188C>T	c.(187-189)gCg>gTg	p.A63V	GPR113_ENST00000311519.1_Missense_Mutation_p.A122V|GPR113_ENST00000541401.1_Intron|GPR113_ENST00000459892.1_5'UTR|GPR113_ENST00000421160.2_Missense_Mutation_p.A53V	NM_153835.3	NP_722577.2	Q8IZF5	GP113_HUMAN	G protein-coupled receptor 113	122					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGACCAGCGCTGATTCTAC	0.592000													8	6					0	0	1	0	0
KIFC3	3801	broad.mit.edu	37	16	57798061	57798061	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57798061C>T	ENST00000379655.4	-	12	1868	c.1611G>A	c.(1609-1611)acG>acA	p.T537T	KIFC3_ENST00000541240.1_Silent_p.T559T|KIFC3_ENST00000465878.2_Silent_p.T398T|KIFC3_ENST00000543930.1_Silent_p.T395T|KIFC3_ENST00000540079.2_Silent_p.T435T|KIFC3_ENST00000539578.1_Silent_p.T479T|KIFC3_ENST00000445690.2_Silent_p.T537T|KIFC3_ENST00000421376.2_Silent_p.T398T|KIFC3_ENST00000562903.1_Silent_p.T398T	NM_005550.3	NP_005541.3	Q9BVG8	KIFC3_HUMAN	kinesin family member C3	537	Kinesin-motor.				epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(3)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(199;0.224)				CCACCTCCATCGTGTACGTCT	0.577000													11	25					0	0	1	0	0
GPR113	165082	broad.mit.edu	37	2	26534169	26534169	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:26534169G>A	ENST00000333478.6	-	8	2412	c.1830C>T	c.(1828-1830)caC>caT	p.H610H	GPR113_ENST00000311519.1_Silent_p.H809H|GPR113_ENST00000541401.1_Silent_p.H412H|GPR113_ENST00000459892.1_5'UTR|GPR113_ENST00000421160.2_Silent_p.H740H	NM_153835.3	NP_722577.2	Q8IZF5	GP113_HUMAN	G protein-coupled receptor 113	809					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCAGGGCGGCGTGGCGGAAAT	0.622000													5	11					0	0	1	0	0
OSBPL8	114882	broad.mit.edu	37	12	76844712	76844712	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:76844712G>A	ENST00000261183.3	-	4	615	c.136C>T	c.(136-138)Cgc>Tgc	p.R46C	OSBPL8_ENST00000393249.2_Missense_Mutation_p.R4C|OSBPL8_ENST00000393250.4_Missense_Mutation_p.R4C	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	46					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						TTTCCTTGGCGCTGACTCATC	0.443000													4	64					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23853677	23853677	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23853677G>A	ENST00000405093.3	-	36	5609	c.5539C>T	c.(5539-5541)Cgg>Tgg	p.R1847W	MYH6_ENST00000356287.3_Missense_Mutation_p.R1847W	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1847					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TTGATGCGCCGCTCGCTCTTC	0.652000													50	85					0	0	1	0	0
RMI1	80010	broad.mit.edu	37	9	86617190	86617190	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:86617190C>T	ENST00000325875.3	+	3	1621	c.1289C>T	c.(1288-1290)aCc>aTc	p.T430I		NM_024945.2	NP_079221.2	Q9H9A7	RMI1_HUMAN	RecQ mediated genome instability 1	430					DNA replication	nucleus				biliary_tract(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						ATAAAACAAACCAGCAGTTCA	0.284000													19	28					0	0	1	0	0
EFCAB13	124989	broad.mit.edu	37	17	45456578	45456578	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:45456578T>C	ENST00000331493.2	+	14	1952	c.1541T>C	c.(1540-1542)gTa>gCa	p.V514A	EFCAB13_ENST00000517484.1_Missense_Mutation_p.V418A	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		GATGACTTTGTAAATGCTCTC	0.338000													9	32					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158639538	158639538	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158639538G>A	ENST00000368148.3	-	13	1818	c.1638C>T	c.(1636-1638)gaC>gaT	p.D546D	SPTA1_ENST00000368147.3_Silent_p.D546D	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	546					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AATCATAATGGTCATCACCAA	0.408000													70	101					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112667566	112667566	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112667566G>A	ENST00000550722.1	-	41	6412	c.6017C>T	c.(6016-6018)gCc>gTc	p.A2006V	HECTD4_ENST00000377560.5_Missense_Mutation_p.A1980V|HECTD4_ENST00000430131.2_Missense_Mutation_p.A1730V	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGCGGCAACGGCCTGGCGTGC	0.493000													38	43					0	0	1	0	0
MARCH5	54708	broad.mit.edu	37	10	94109442	94109442	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:94109442G>A	ENST00000358935.2	+	5	900	c.568G>A	c.(568-570)Gtt>Att	p.V190I	MARCH5_ENST00000467521.2_3'UTR	NM_017824.4	NP_060294.1	Q9NX47	MARH5_HUMAN	membrane-associated ring finger (C3HC4) 5	190					cell aging|protein autoubiquitination|protein localization in mitochondrion|protein polyubiquitination|regulation of mitochondrial fission	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	GTPase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						AGGTTGTCCTGTTCCTCGAAT	0.413000													125	174					0	0	1	0	0
HLA-DRB5	3127	broad.mit.edu	37	6	32489898	32489898	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32489898G>A	ENST00000374975.3	-	2	216	c.154C>T	c.(154-156)Cgg>Tgg	p.R52W		NM_002125.3	NP_002116.2	Q30154	DRB5_HUMAN	major histocompatibility complex, class II, DR beta 5	52	Beta-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex				NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|stomach(2)	10						AACCGCACCCGCTCCGTCCCG	0.617000													9	14					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74492275	74492275	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74492275G>A	ENST00000394019.2	-	9	915	c.518C>T	c.(517-519)aCg>aTg	p.T173M	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Missense_Mutation_p.T173M|SLC4A5_ENST00000357822.5_Missense_Mutation_p.T173M|SLC4A5_ENST00000377632.1_Missense_Mutation_p.T173M|SLC4A5_ENST00000359484.4_Missense_Mutation_p.T109M|SLC4A5_ENST00000358683.4_Missense_Mutation_p.T109M|SLC4A5_ENST00000346834.4_Missense_Mutation_p.T173M|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377634.4_Missense_Mutation_p.T173M	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	173						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CAGCAGCACCGTCCCCGTCTG	0.607000													8	38					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100346680	100346680	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:100346680G>A	ENST00000294724.4	+	15	2426	c.1948G>A	c.(1948-1950)Gca>Aca	p.A650T	AGL_ENST00000370161.2_Missense_Mutation_p.A634T|AGL_ENST00000361302.3_Missense_Mutation_p.A634T|AGL_ENST00000361915.3_Missense_Mutation_p.A650T|AGL_ENST00000370165.3_Missense_Mutation_p.A650T|AGL_ENST00000361522.4_Missense_Mutation_p.A633T|AGL_ENST00000370163.3_Missense_Mutation_p.A650T	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	650					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TGTTTCTATGGCATGTTGTGC	0.368000													25	38					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31545313	31545313	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:31545313G>A	ENST00000389082.5	-	19	3618	c.3354C>T	c.(3352-3354)acC>acT	p.T1118T	DENND5B_ENST00000536562.1_Silent_p.T1153T|DENND5B_ENST00000306833.6_Silent_p.T1153T	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1118	RUN 2.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						ACAGCAACACGGTGAGGCTTC	0.463000													13	19					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21008665	21008665	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:21008665C>T	ENST00000261383.3	-	44	6540	c.6541G>A	c.(6541-6543)Gtg>Atg	p.V2181M	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2181	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGCATGTCCACGATGTCCAGC	0.552000													26	34					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179449464	179449464	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179449464C>T	ENST00000589042.1	-	310	65128	c.64904G>A	c.(64903-64905)cGt>cAt	p.R21635H	TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R12762H|TTN_ENST00000591111.1_Missense_Mutation_p.R19994H|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R12570H|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R19067H|TTN_ENST00000359218.5_Missense_Mutation_p.R12695H|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19994	Fibronectin type-III 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R12695H(1)|p.R19065H(1)|p.R12570H(1)|p.R12762H(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTTCAGCACGGACCCGGAA	0.488000													73	90					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47955197	47955197	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:47955197C>A	ENST00000289672.2	-	8	1111		c.e8-1			NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1						cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						aaaaaaatacctataaaagca	0.274000													7	18					5.18039e-06	5.37127e-06	1	1	0
IL36A	27179	broad.mit.edu	37	2	113763657	113763657	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:113763657G>A	ENST00000259211.6	+	2	528	c.117G>A	c.(115-117)atG>atA	p.M39I		NM_014440.1	NP_055255.1	Q9UHA7	IL36A_HUMAN	interleukin 36, alpha	39					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding			large_intestine(1)|lung(3)|ovary(2)|skin(1)|stomach(2)	9						AGGACCGTATGTCTCCAGGTG	0.522000													11	20					0	0	1	0	0
SSTR5	0	broad.mit.edu	37	16	1129348	1129348	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1129348C>T	ENST00000293897.4	+	1	568	c.480C>T	c.(478-480)agC>agT	p.S160S	SSTR5_ENST00000562758.1_Silent_p.S160S|SSTR5_ENST00000397547.2_Silent_p.S160S	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	160					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	AGCTGGCGAGCGCCGCGGCCT	0.711000													8	6					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67260513	67260513	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67260513G>A	ENST00000356404.3	-	23	3588	c.3363C>T	c.(3361-3363)gcC>gcT	p.A1121A	PITPNM1_ENST00000436757.2_Silent_p.A1120A|PITPNM1_ENST00000534749.1_Silent_p.A1121A	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	1121					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						ACCCATAACCGGCCACGATGT	0.662000													44	78					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113208265	113208265	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:113208265C>T	ENST00000401783.2	-	26	4651	c.4315G>A	c.(4315-4317)Gtc>Atc	p.V1439I	SVEP1_ENST00000302728.8_Missense_Mutation_p.V1439I|SVEP1_ENST00000374469.1_Missense_Mutation_p.V1416I|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1439	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TCTAGCATGACATATCCATAG	0.433000													9	12					0	0	1	0	0
FRMD1	79981	broad.mit.edu	37	6	168461456	168461456	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:168461456G>A	ENST00000283309.6	-	9	1391	c.1327C>T	c.(1327-1329)Cgt>Tgt	p.R443C	FRMD1_ENST00000440994.2_Missense_Mutation_p.R375C|FRMD1_ENST00000537786.1_Missense_Mutation_p.R214C|FRMD1_ENST00000432403.1_5'UTR	NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	443						cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CTGTCACCACGTGTGCTGGGG	0.667000													9	18					0	0	1	0	0
QPCT	25797	broad.mit.edu	37	2	37599550	37599550	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:37599550G>A	ENST00000338415.3	+	6	1033	c.875G>A	c.(874-876)cGg>cAg	p.R292Q	QPCT_ENST00000537448.1_Missense_Mutation_p.R243Q	NM_012413.3	NP_036545.1	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase	292					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|stomach(2)	17		Ovarian(717;0.051)|all_hematologic(82;0.21)				TTGGAGGGGCGGTATTTCCAG	0.368000													64	96					0	0	1	0	0
ATAD3A	55210	broad.mit.edu	37	1	1469346	1469346	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1469346C>T	ENST00000378755.5	+	16	1893	c.1799C>T	c.(1798-1800)gCc>gTc	p.A600V	ATAD3A_ENST00000536055.1_Missense_Mutation_p.A473V|ATAD3A_ENST00000378756.3_Missense_Mutation_p.A552V	NM_018188.3	NP_060658.3	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	600							ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(4)|kidney(6)|large_intestine(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		CTGACCGAGGCCATGATGGAC	0.672000													22	31					0	0	1	0	0
USP29	0	broad.mit.edu	37	19	57640482	57640482	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:57640482C>T	ENST00000254181.4	+	4	893	c.439C>T	c.(439-441)Cct>Tct	p.P147S	USP29_ENST00000598197.1_Missense_Mutation_p.P147S	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	147					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCAGAAGATGCCTTTGTTTAT	0.363000													20	33					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58287286	58287286	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:58287286T>C	ENST00000249750.4	-	5	1312	c.545A>G	c.(544-546)cAg>cGg	p.Q182R	ALDH1A2_ENST00000558231.1_Missense_Mutation_p.Q153R|ALDH1A2_ENST00000537372.1_Missense_Mutation_p.Q161R|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.Q182R|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.Q86R	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	182					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TGGGATGATCTGTCCACACAC	0.393000													36	51					0	0	1	0	0
ZDHHC16	84287	broad.mit.edu	37	10	99211512	99211512	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99211512G>A	ENST00000393760.1	+	3	429	c.80G>A	c.(79-81)cGc>cAc	p.R27H	ZDHHC16_ENST00000370842.2_Missense_Mutation_p.R27H|ZDHHC16_ENST00000345745.5_Missense_Mutation_p.R27H|ZDHHC16_ENST00000370854.3_Missense_Mutation_p.R27H|ZDHHC16_ENST00000352634.4_Missense_Mutation_p.R27H|ZDHHC16_ENST00000370846.4_Missense_Mutation_p.R27H|ZDHHC16_ENST00000353979.3_Missense_Mutation_p.R27H|ZDHHC16_ENST00000495735.1_3'UTR	NM_198046.1	NP_932163.1	Q969W1	ZDH16_HUMAN	zinc finger, DHHC-type containing 16	27					apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	14		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		TACAGGCGCCGCTGTCCACCT	0.667000													21	21					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	197878290	197878290	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:197878290G>A	ENST00000328737.2	-	18	1870	c.1794C>T	c.(1792-1794)ggC>ggT	p.G598G	ANKRD44_ENST00000450567.1_Silent_p.G598G|ANKRD44_ENST00000337207.5_Silent_p.G598G|ANKRD44_ENST00000282272.8_Silent_p.G615G			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	623							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AGATGGATGCGCCCTGATTGA	0.493000													59	70					0	0	1	0	0
SLC9B2	133308	broad.mit.edu	37	4	103947622	103947622	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:103947622G>A	ENST00000503103.1	-	10	1401	c.1211C>T	c.(1210-1212)tCt>tTt	p.S404F	SLC9B2_ENST00000362026.3_Silent_p.L507L|SLC9B2_ENST00000394785.3_Silent_p.L507L|SLC9B2_ENST00000339611.4_Intron|SLC9B2_ENST00000503230.1_Silent_p.L450L			Q86UD5	NHDC2_HUMAN	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	0					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity										CCAATAAGCAGACTTCCAATT	0.433000													30	53					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326915	152326915	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:152326915C>T	ENST00000388718.5	-	3	3419	c.3347G>A	c.(3346-3348)gGc>gAc	p.G1116D	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1116	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCATATTGGCCAAAGCCAGA	0.502000													89	165					0	0	1	0	0
RP11-909M7.3	0	broad.mit.edu	37	14	101435337	101435337	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:101435337G>A	ENST00000554693.2	+	0	212				SNORD114-12_ENST00000365400.1_RNA																							TGAATAATACGTGTCTGGAAC	0.363000													8	50					0	0	1	0	0
CNBP	7555	broad.mit.edu	37	3	128890476	128890476	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:128890476C>A	ENST00000422453.2	-	2	285		c.e2+1		CNBP_ENST00000500450.2_Intron|CNBP_ENST00000502976.1_Intron|CNBP_ENST00000451728.2_Splice_Site|CNBP_ENST00000441626.2_Splice_Site|CNBP_ENST00000504813.1_Splice_Site|CNBP_ENST00000446936.2_Intron	NM_001127192.1|NM_001127193.1|NM_003418.4	NP_001120664.1|NP_001120665.1|NP_003409.1	P62633	CNBP_HUMAN	CCHC-type zinc finger, nucleic acid binding protein						cholesterol biosynthetic process	endoplasmic reticulum	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			biliary_tract(1)|endometrium(1)|kidney(1)|lung(2)	5						CGACAAAATACCTCTATCCGA	0.468000													5	37					0.014758	0.0148771	1	1	0
AMPD2	271	broad.mit.edu	37	1	110170723	110170723	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110170723G>A	ENST00000256578.3	+	10	1621	c.1261G>A	c.(1261-1263)Gcc>Acc	p.A421T	AMPD2_ENST00000358729.4_Missense_Mutation_p.A346T|AMPD2_ENST00000393688.3_Missense_Mutation_p.A302T|AMPD2_ENST00000342115.4_Missense_Mutation_p.A340T|AMPD2_ENST00000528667.1_Missense_Mutation_p.A421T|AMPD2_ENST00000528454.1_Missense_Mutation_p.A303T|AMPD2_ENST00000526301.1_3'UTR	NM_004037.7	NP_004028.3	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2	421					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCACATCCATGCCTCGTCCTG	0.607000													7	7					0	0	1	0	0
FAM160B1	57700	broad.mit.edu	37	10	116621019	116621019	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:116621019G>T	ENST00000369248.4	+	16	2453	c.2118G>T	c.(2116-2118)caG>caT	p.Q706H	FAM160B1_ENST00000369250.3_Missense_Mutation_p.Q706H	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	706										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						TTCGAATCCAGCGTATTCAAG	0.418000													18	43					0.204396	0.204795	1	1	0
RAPH1	65059	broad.mit.edu	37	2	204304354	204304354	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:204304354G>A	ENST00000319170.5	-	14	3858	c.3559C>T	c.(3559-3561)Cgc>Tgc	p.R1187C	RAPH1_ENST00000374493.3_Missense_Mutation_p.R1239C|RAPH1_ENST00000457812.1_Intron	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	1187					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CTGGACATGCGGGAGGAGAGT	0.562000													16	22					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587868	247587868	+	Missense_Mutation	SNP	G	G	A	rs61841179		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247587868G>A	ENST00000366497.2	+	4	1903	c.1123G>A	c.(1123-1125)Gag>Aag	p.E375K	NLRP3_ENST00000391828.3_Missense_Mutation_p.E375K|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000336119.3_Missense_Mutation_p.E375K|NLRP3_ENST00000348069.2_Missense_Mutation_p.E375K|NLRP3_ENST00000366496.2_Missense_Mutation_p.E375K|NLRP3_ENST00000391827.2_Missense_Mutation_p.E375K	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	375	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GGGTTTCTCCGAGGCCAAAAG	0.552000													17	45					0	0	1	0	0
EMX2	2018	broad.mit.edu	37	10	119305160	119305160	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:119305160G>A	ENST00000553456.3	+	2	1248	c.424G>A	c.(424-426)Gag>Aag	p.E142K	EMX2_ENST00000442245.4_Intron|EMX2_ENST00000546446.1_3'UTR	NM_004098.3	NP_004089.1	Q04743	EMX2_HUMAN	empty spiracles homeobox 2	142						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(2)	12		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		CACTAGCCCCGAGAGTTTCCT	0.642000													7	20					0	0	1	0	0
CACNB2	783	broad.mit.edu	37	10	18439868	18439868	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:18439868G>A	ENST00000282343.8	+	2	315	c.93G>A	c.(91-93)acG>acA	p.T31T	CACNB2_ENST00000467034.1_3'UTR|CACNB2_ENST00000377331.2_Silent_p.T31T|CACNB2_ENST00000352115.6_Silent_p.T59T|CACNB2_ENST00000324631.7_Silent_p.T59T|CACNB2_ENST00000377328.1_Silent_p.T59T	NM_001167945.1|NM_201571.3	NP_001161417.1|NP_963865.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	59					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATGGAAGCACGTCATCTGATA	0.294000													32	83					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8152025	8152025	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:8152025A>G	ENST00000600128.1	-	54	7104	c.6690T>C	c.(6688-6690)ggT>ggC	p.G2230G	FBN3_ENST00000270509.2_Silent_p.G2230G|FBN3_ENST00000601739.1_Silent_p.G2230G			Q75N90	FBN3_HUMAN	fibrillin 3	2230	EGF-like 36; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ACGCGAAGGTACCGATGAGGT	0.622000													16	43					0	0	1	0	0
ATAD3B	83858	broad.mit.edu	37	1	1421968	1421968	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1421968C>T	ENST00000308647.7	+	11	1250	c.1134C>T	c.(1132-1134)ggC>ggT	p.G378G		NM_031921.4	NP_114127.3	Q5T9A4	ATD3B_HUMAN	ATPase family, AAA domain containing 3B	378							ATP binding|nucleoside-triphosphatase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCATGACAGGCGGGGACGTGG	0.617000													6	20					0	0	1	0	0
FRK	2444	broad.mit.edu	37	6	116263644	116263644	+	Missense_Mutation	SNP	C	C	T	rs141525046	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:116263644C>T	ENST00000606080.1	-	8	1897	c.1451G>A	c.(1450-1452)cGt>cAt	p.R484H	FRK_ENST00000538210.1_Missense_Mutation_p.R342H	NM_002031.2	NP_002022.1	P42685	FRK_HUMAN	fyn-related kinase	484	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.R484L(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|skin(1)|urinary_tract(1)	27		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		AAGTTTCCAACGCAGTGTCTC	0.388000													22	40					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176008535	176008535	+	Silent	SNP	C	C	T	rs139851773		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176008535C>T	ENST00000510636.1	+	17	2284	c.2010C>T	c.(2008-2010)tgC>tgT	p.C670C	CDHR2_ENST00000506348.1_Silent_p.C670C|CDHR2_ENST00000261944.5_Silent_p.C670C	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	670	Cadherin 6.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						TGTCTGACTGCGGCGAGCCTG	0.637000													12	25					0	0	1	0	0
SYN3	8224	broad.mit.edu	37	22	33402644	33402644	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:33402644T>C	ENST00000358763.2	-	2	246	c.4A>G	c.(4-6)Aat>Gat	p.N2D	SYN3_ENST00000332840.5_Missense_Mutation_p.N2D	NM_001135774.1	NP_001129246.1	O14994	SYN3_HUMAN	synapsin III	2	A.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						CGGAGGAAATTCATGGCTGTG	0.572000											OREG0003521	type=REGULATORY REGION|Gene=SYN3|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	24	34					0	0	1	0	0
EDEM3	80267	broad.mit.edu	37	1	184695464	184695464	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:184695464G>T	ENST00000318130.8	-	7	938	c.672C>A	c.(670-672)acC>acA	p.T224T	EDEM3_ENST00000367512.3_Silent_p.T181T	NM_025191.3	NP_079467.3	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like 3	224					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						AAGCTGTACAGGTATCTGTCT	0.373000													31	46					3.1745e-13	3.44526e-13	1	1	0
PIFO	128344	broad.mit.edu	37	1	111889622	111889622	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:111889622T>C	ENST00000369738.4	+	2	475	c.110T>C	c.(109-111)gTc>gCc	p.V37A	PIFO_ENST00000369737.4_Missense_Mutation_p.V37A|PIFO_ENST00000484512.1_3'UTR	NM_181643.4	NP_857594.2			primary cilia formation																		AACAAGTTTGTCCCTCTTAGG	0.473000													18	31					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26551961	26551961	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:26551961G>T	ENST00000381340.3	-	54	7960	c.7544C>A	c.(7543-7545)gCt>gAt	p.A2515D	RP11-513G19.1_ENST00000535324.1_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2515					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					CACTCGGGCAGCAAACAAGGG	0.328000													16	19					3.41278e-10	3.64137e-10	1	1	0
OR5C1	392391	broad.mit.edu	37	9	125551311	125551311	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:125551311A>G	ENST00000373680.2	+	1	162	c.100A>G	c.(100-102)Acc>Gcc	p.T34A		NM_001001923.1	NP_001001923.1	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C, member 1	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(5)|skin(1)	20						CCTCTTCCTGACCTGCCTGCC	0.607000													19	25					0	0	1	0	0
PCDHB2	0	broad.mit.edu	37	5	140475094	140475094	+	Silent	SNP	C	C	T	rs112071111		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140475094C>T	ENST00000194155.4	+	1	868	c.720C>T	c.(718-720)aaC>aaT	p.N240N		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		240	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAATGACAACGTCCCAGAGT	0.567000													14	27					0	0	1	0	0
BAK1	578	broad.mit.edu	37	6	33543083	33543083	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33543083A>G	ENST00000374467.3	-	4	590	c.342T>C	c.(340-342)atT>atC	p.I114I	BAK1_ENST00000360661.5_Silent_p.I114I|BAK1_ENST00000442998.2_Silent_p.I114I	NM_001188.3	NP_001179.1	Q16611	BAK_HUMAN	BCL2-antagonist/killer 1	114					activation of pro-apoptotic gene products|cellular response to mechanical stimulus|cellular response to UV|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria	integral to mitochondrial outer membrane|pore complex	metal ion binding|protein heterodimerization activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4						ACCTGGTGGCAATCTTGGTGA	0.567000													12	19					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511164	61511164	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:61511164G>A	ENST00000266070.4	-	16	6469	c.6144C>T	c.(6142-6144)tcC>tcT	p.S2048S	DIDO1_ENST00000395343.1_Silent_p.S2048S	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	2048					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					AGGAGAGCGCGGAGGGCGGCC	0.721000													34	50					0	0	1	0	0
DKK3	27122	broad.mit.edu	37	11	12029974	12029974	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:12029974G>A	ENST00000396505.2	-	2	394	c.156C>T	c.(154-156)cgC>cgT	p.R52R	DKK3_ENST00000450094.2_Silent_p.R52R|DKK3_ENST00000326932.4_Silent_p.R52R|DKK3_ENST00000525493.1_Silent_p.R52R|DKK3_ENST00000527132.1_5'UTR	NM_015881.5	NP_056965.3	Q9UBP4	DKK3_HUMAN	dickkopf WNT signaling pathway inhibitor 3	52					adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|pancreas(1)	8				Epithelial(150;0.000502)		CCTCAACCTCGCGGAACATCT	0.697000													9	13					0	0	1	0	0
BBS12	166379	broad.mit.edu	37	4	123664110	123664110	+	Nonsense_Mutation	SNP	C	C	T	rs121918327		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:123664110C>T	ENST00000542236.1	+	3	1444	c.1063C>T	c.(1063-1065)Cga>Tga	p.R355*	BBS12_ENST00000314218.3_Nonsense_Mutation_p.R355*	NM_001178007.1	NP_001171478.1	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	355					cellular protein metabolic process	cilium	ATP binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|prostate(4)	21						TCAGCCTGTGCGAATAGTTCT	0.403000									Bardet-Biedl syndrome				21	27					0	0	1	0	0
IL12RB1	0	broad.mit.edu	37	19	18193064	18193064	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18193064C>T	ENST00000600835.1	-	4	438	c.135G>A	c.(133-135)tcG>tcA	p.S45S	IL12RB1_ENST00000322153.6_Silent_p.S45S|IL12RB1_ENST00000593993.1_Silent_p.S45S|IL12RB1_ENST00000430026.2_Silent_p.S45S			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	45	Fibronectin type-III 1.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCCTAGGGCCCGAGGCCGAGC	0.552000													3	9					0	0	1	0	0
RPAP1	26015	broad.mit.edu	37	15	41819399	41819399	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:41819399C>T	ENST00000304330.4	-	13	1828	c.1712G>A	c.(1711-1713)cGc>cAc	p.R571H	RPAP1_ENST00000561603.1_Missense_Mutation_p.R571H	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	571						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CCGGGCCAGGCGGATGAGCAC	0.617000													10	21					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	662873	662873	+	Missense_Mutation	SNP	C	C	T	rs148059237	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:662873C>T	ENST00000266383.5	+	14	1797	c.1784C>T	c.(1783-1785)gCg>gTg	p.A595V		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	595						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GAAGTGGTGGCGGCCGCAGGC	0.607000													13	26					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127236393	127236393	+	Missense_Mutation	SNP	C	C	T	rs148605578		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:127236393C>T	ENST00000265825.5	+	3	1072	c.853C>T	c.(853-855)Cgt>Tgt	p.R285C	FSCN3_ENST00000420086.2_Missense_Mutation_p.R151C	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	285						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging	p.R285C(2)		endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						TGGTGAGGTGCGTGCTGCTTC	0.552000													55	87					0	0	1	0	0
CHAT	1103	broad.mit.edu	37	10	50872967	50872967	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:50872967G>A	ENST00000395562.2	+	16	2345	c.1876G>A	c.(1876-1878)Gca>Aca	p.A626T	CHAT_ENST00000395559.2_Missense_Mutation_p.A590T|CHAT_ENST00000337653.2_Missense_Mutation_p.A708T|CHAT_ENST00000339797.1_Missense_Mutation_p.A590T|CHAT_ENST00000351556.3_Missense_Mutation_p.A590T|CHAT_ENST00000455728.2_Intron	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	708					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TAGCAAGTTTGCAAAAGCTGT	0.502000													67	79					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101591981	101591981	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:101591981G>A	ENST00000335681.5	+	14	1629	c.1344G>A	c.(1342-1344)ctG>ctA	p.L448L	NPAS2_ENST00000542504.1_Silent_p.L513L|AC016738.3_ENST00000439150.1_RNA|AC016738.3_ENST00000446644.1_RNA	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	448					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CAGCCACCCTGCCCCAAGAGT	0.582000													9	81					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63125774	63125774	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:63125774C>T	ENST00000561311.1	+	54	7304	c.7074C>T	c.(7072-7074)agC>agT	p.S2358S	TLN2_ENST00000306829.6_Silent_p.S2358S|RP11-1069G10.1_ENST00000558888.1_RNA			Q9Y4G6	TLN2_HUMAN	talin 2	2358	I/LWEQ.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CTGCCACAAGCGCCCTGGTCA	0.537000													35	45					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110031508	110031508	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110031508G>A	ENST00000369870.3	+	7	838	c.823G>A	c.(823-825)Gcc>Acc	p.A275T		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	275	SCA7.									breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCAGGGCCGGGCCAAGGACTT	0.597000													6	42					0	0	1	0	0
CCL8	6355	broad.mit.edu	37	17	32647883	32647883	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:32647883C>T	ENST00000394620.1	+	3	723	c.257C>T	c.(256-258)tCc>tTc	p.S86F		NM_005623.2	NP_005614.2	P80075	CCL8_HUMAN	chemokine (C-C motif) ligand 8	86					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity			NS(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Ovarian(249;0.0443)|Breast(31;0.151)				GTCAGGGATTCCATGAAGCAT	0.468000													8	13					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46942206	46942206	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:46942206G>T	ENST00000429979.1	-	5	1401	c.797C>A	c.(796-798)tCt>tAt	p.S266Y	KIAA0226L_ENST00000389908.3_Missense_Mutation_p.S266Y|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.S266Y|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.S266Y|KIAA0226L_ENST00000409879.2_Missense_Mutation_p.S109Y|KIAA0226L_ENST00000322896.6_Missense_Mutation_p.S109Y|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.S266Y|KIAA0226L_ENST00000534925.1_Missense_Mutation_p.S131Y|KIAA0226L_ENST00000378784.4_Missense_Mutation_p.S199Y	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	266										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						AGAAGTAGAAGACCCAGACTC	0.408000													58	97					6.20203e-27	6.93455e-27	1	1	0
FAT3	120114	broad.mit.edu	37	11	92616214	92616214	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:92616214G>A	ENST00000298047.6	+	23	12609	c.12592G>A	c.(12592-12594)Gcc>Acc	p.A4198T	FAT3_ENST00000409404.2_Missense_Mutation_p.A4198T|FAT3_ENST00000533797.1_Missense_Mutation_p.A533T|FAT3_ENST00000525166.1_Missense_Mutation_p.A4048T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4198					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCCGGCCACCGCCGCCCTGCT	0.617000										TCGA Ovarian(4;0.039)			13	28					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38022223	38022223	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:38022223C>T	ENST00000261439.4	+	5	1339	c.984C>T	c.(982-984)caC>caT	p.H328H	TBC1D1_ENST00000508802.1_Silent_p.H328H	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	328	PID.					nucleus	Rab GTPase activator activity	p.H328H(1)		NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						GCATCAGACACGTGGACCACT	0.483000													51	71					0	0	1	0	0
SPPL2B	56928	broad.mit.edu	37	19	2352991	2352991	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2352991G>A	ENST00000452401.2	+	0	1703				AC005258.3_ENST00000590001.1_RNA			Q8TCT7	PSL1_HUMAN	signal peptide peptidase like 2B							Golgi membrane|integral to membrane	aspartic-type endopeptidase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGACGGCCCGCAGCCTCCCA	0.657000													8	12					0	0	1	0	0
ZNF429	353088	broad.mit.edu	37	19	21719314	21719314	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:21719314C>A	ENST00000358491.4	+	4	667	c.459C>A	c.(457-459)gtC>gtA	p.V153V	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	153					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						ATGTAAAAGTCTTTTATGCAT	0.333000													19	23					3.99206e-14	4.34914e-14	1	1	0
FXR2	9513	broad.mit.edu	37	17	7499262	7499262	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7499262C>A	ENST00000250113.7	-	8	1045	c.711G>T	c.(709-711)gaG>gaT	p.E237D		NM_004860.3	NP_004851.2	P51116	FXR2_HUMAN	fragile X mental retardation, autosomal homolog 2	237	KH 1.					cytosolic large ribosomal subunit	protein binding|RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)	26				READ - Rectum adenocarcinoma(115;0.17)		CCATCAGGTCCTCTCGCACTG	0.537000													56	75					2.01871e-26	2.25616e-26	1	1	0
CHD5	26038	broad.mit.edu	37	1	6166714	6166714	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:6166714G>A	ENST00000262450.3	-	39	5803	c.5704C>T	c.(5704-5706)Cgc>Tgc	p.R1902C	CHD5_ENST00000378021.1_Missense_Mutation_p.R759C	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1902					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TTGGTCAGGCGGCTCAGGATG	0.736000													8	4					0	0	1	0	0
SREBF1	6720	broad.mit.edu	37	17	17721180	17721180	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:17721180C>T	ENST00000355815.4	-	8	1493	c.1324G>A	c.(1324-1326)Gtg>Atg	p.V442M	SREBF1_ENST00000338854.5_Missense_Mutation_p.V412M|SREBF1_ENST00000261646.5_Missense_Mutation_p.V412M|SREBF1_ENST00000395757.1_Missense_Mutation_p.V158M|SREBF1_ENST00000435530.2_Missense_Mutation_p.V412M	NM_001005291.2	NP_001005291.1	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription factor 1	412	Gly/Pro/Ser-rich.|Interaction with LMNA (By similarity).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	14						TCCATGAGCACGTCTGTGTTC	0.597000													30	37					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70152508	70152508	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:70152508T>C	ENST00000335568.5	+	3	911	c.909T>C	c.(907-909)ggT>ggC	p.G303G	UGT2B28_ENST00000511240.1_Silent_p.G303G	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	303					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	GTGAAAATGGTGTTGTGGTGT	0.408000													68	164					0	0	1	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122280506	122280506	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:122280506G>A	ENST00000398250.1	+	5	696	c.344G>A	c.(343-345)cGc>cAc	p.R115H	PPAPDC1A_ENST00000369073.3_Missense_Mutation_p.R105H|PPAPDC1A_ENST00000439221.1_Intron|PPAPDC1A_ENST00000541332.1_Missense_Mutation_p.R115H|PPAPDC1A_ENST00000398248.1_Intron	NM_001030059.1	NP_001025230.1	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain containing 1A	115					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	20		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		TTCTTTTACCGCTGCTTTCCA	0.517000													18	127					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3673761	3673761	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:3673761G>A	ENST00000344754.4	-	14	3525	c.3526C>T	c.(3526-3528)Cgc>Tgc	p.R1176C	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.R1176C	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1176	Ig-like C2-type 12.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						TAGGTCAGGCGCAGGTTGCGG	0.677000													7	14					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35392446	35392446	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:35392446C>T	ENST00000311565.4	+	8	1317	c.968C>T	c.(967-969)cCc>cTc	p.P323L	PPARD_ENST00000337400.2_Missense_Mutation_p.P323L|PPARD_ENST00000540939.1_Missense_Mutation_p.P220L|PPARD_ENST00000418635.2_Missense_Mutation_p.P225L|PPARD_ENST00000448077.2_Missense_Mutation_p.P284L|PPARD_ENST00000444397.1_Missense_Mutation_p.P323L|PPARD_ENST00000360694.3_Missense_Mutation_p.P323L	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	323	Ligand-binding.				apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	CTCCGCAAACCCTTCAGTGAT	0.527000													14	12					0	0	1	0	0
RP11-419C5.2	0	broad.mit.edu	37	16	70029987	70029987	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:70029987G>A	ENST00000532298.1	-	1	104	c.105C>T	c.(103-105)tgC>tgT	p.C35C	PDXDC2P_ENST00000531894.1_RNA|RP11-419C5.2_ENST00000325845.7_5'UTR																breast(2)|endometrium(2)|kidney(6)|lung(2)|prostate(1)	13						TCAGGTACTCGCATGGGCATG	0.587000													4	9					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76471508	76471508	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:76471508C>A	ENST00000389840.5	-	54	8445	c.8321G>T	c.(8320-8322)cGc>cTc	p.R2774L	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.R2783L					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CTCCAGGATGCGATTAATCCT	0.602000													25	28					2.12542e-12	2.29988e-12	1	1	0
GPR108	56927	broad.mit.edu	37	19	6732129	6732129	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6732129C>T	ENST00000264080.7	-	13	1189	c.1163G>A	c.(1162-1164)cGc>cAc	p.R388H	GPR108_ENST00000430424.4_Missense_Mutation_p.R146H	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	388						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						GCCTTCCTCGCGGGACTCGAT	0.642000													6	18					0	0	1	0	0
FAM120AOS	158293	broad.mit.edu	37	9	96214909	96214909	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:96214909A>G	ENST00000375412.5	-	1	965	c.83T>C	c.(82-84)gTc>gCc	p.V28A	FAM120A_ENST00000333936.5_Intron|FAM120A_ENST00000340893.4_Intron|FAM120A_ENST00000375389.3_Intron|FAM120A_ENST00000277165.6_Intron	NM_198841.2	NP_942138.2	Q5T036	F120S_HUMAN	family with sequence similarity 120A opposite strand	28										kidney(1)|large_intestine(1)|lung(3)|skin(1)	6						CCGCGTGGGGACACTTGAGGG	0.662000													9	20					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30659548	30659548	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:30659548C>A	ENST00000534862.1	+	3	449	c.86C>A	c.(85-87)cCt>cAt	p.P29H	HCK_ENST00000518730.1_Missense_Mutation_p.P28H|HCK_ENST00000375862.2_Missense_Mutation_p.P49H|HCK_ENST00000520553.1_Missense_Mutation_p.P28H|HCK_ENST00000375852.2_Missense_Mutation_p.P49H|HCK_ENST00000538448.1_Missense_Mutation_p.P28H	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	49					interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCACACTGTCCTGTGTACGTG	0.577000													8	23					0.000157383	0.000161063	1	1	0
ANKAR	150709	broad.mit.edu	37	2	190611229	190611229	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190611229A>C	ENST00000520309.1	+	23	4269	c.4181A>C	c.(4180-4182)aAt>aCt	p.N1394T	ANKAR_ENST00000438402.2_3'UTR|ANKAR_ENST00000431575.2_Missense_Mutation_p.N1323T|ANKAR_ENST00000281412.6_3'UTR|ANKAR_ENST00000313581.4_Missense_Mutation_p.N1394T	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1394						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			GATTCCCATAATATTTTTTCT	0.333000													45	63					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62324233	62324233	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:62324233G>T	ENST00000318100.4	+	29	3555	c.2728G>T	c.(2728-2730)Gcc>Tcc	p.A910S	RTEL1_ENST00000370003.1_Missense_Mutation_p.A155S|RTEL1_ENST00000360203.5_Missense_Mutation_p.A910S|RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.A910S|RTEL1_ENST00000370018.3_Missense_Mutation_p.A910S|RTEL1_ENST00000508582.2_Missense_Mutation_p.A934S			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	910					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GTTGAGCCAAGCCAACTTTGC	0.652000													25	46					3.01185e-09	3.19065e-09	1	1	0
KIAA1328	57536	broad.mit.edu	37	18	34752975	34752975	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:34752975C>A	ENST00000591619.1	+	9	2228	c.1442C>A	c.(1441-1443)cCt>cAt	p.P481H	KIAA1328_ENST00000280020.5_Missense_Mutation_p.P485H|KIAA1328_ENST00000435985.2_Missense_Mutation_p.P237H|KIAA1328_ENST00000543923.1_Missense_Mutation_p.P377H|KIAA1328_ENST00000586135.1_Missense_Mutation_p.P237H			Q86T90	K1328_HUMAN	KIAA1328	485										central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	14				COAD - Colon adenocarcinoma(74;0.195)		TCTACATCTCCTATGCCAACA	0.383000													45	47					3.50607e-19	3.87742e-19	1	1	0
NDUFA13	51079	broad.mit.edu	37	19	19638886	19638886	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19638886C>T	ENST00000507754.3	+	5	887	c.386C>T	c.(385-387)aCc>aTc	p.T129I	CTC-260F20.3_ENST00000555938.1_Intron|NDUFA13_ENST00000252576.5_Missense_Mutation_p.T212I|NDUFA13_ENST00000503283.1_Intron|CTC-260F20.3_ENST00000586674.1_3'UTR					NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	12						GGGCTGCGCACCACAGAGGAG	0.667000													5	9					0	0	1	0	0
RTKN	6242	broad.mit.edu	37	2	74653420	74653420	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74653420C>A	ENST00000305557.5	-	13	2188	c.1603G>T	c.(1603-1605)Ggc>Tgc	p.G535C	RTKN_ENST00000272430.5_Missense_Mutation_p.G548C|RTKN_ENST00000233330.6_Missense_Mutation_p.G498C	NM_033046.2	NP_149035.1	Q9BST9	RTKN_HUMAN	rhotekin	548	Pro-rich.				apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			endometrium(3)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	16						CTGCAGAGGCCTCTGGTCCGT	0.612000													4	96					0.00024832	0.000253518	1	1	0
FAT1	2195	broad.mit.edu	37	4	187629095	187629095	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:187629095C>T	ENST00000441802.2	-	2	2096	c.1887G>A	c.(1885-1887)tcG>tcA	p.S629S		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	629	Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CATCCATTAGCGATCGCTTTA	0.403000										HNSCC(5;0.00058)			37	34					0	0	1	0	0
RGS18	64407	broad.mit.edu	37	1	192127877	192127877	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:192127877C>T	ENST00000367460.3	+	1	291	c.110C>T	c.(109-111)gCc>gTc	p.A37V	RGS18_ENST00000481707.1_3'UTR	NM_130782.2	NP_570138.1	Q9NS28	RGS18_HUMAN	regulator of G-protein signaling 18	37					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			kidney(1)|large_intestine(2)|lung(15)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGCAAAGAAGCCAAAATCAGG	0.284000													4	60					0	0	1	0	0
ZNF385A	25946	broad.mit.edu	37	12	54764451	54764451	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:54764451G>A	ENST00000546970.1	-	8	1118	c.829C>T	c.(829-831)Ctg>Ttg	p.L277L	ZNF385A_ENST00000394313.2_Silent_p.L277L|ZNF385A_ENST00000551109.1_Silent_p.L277L|ZNF385A_ENST00000551771.1_Silent_p.L196L|ZNF385A_ENST00000552382.1_5'UTR|RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA|ZNF385A_ENST00000352268.6_Silent_p.L216L|ZNF385A_ENST00000338010.5_Silent_p.L297L			Q96PM9	Z385A_HUMAN	zinc finger protein 385A	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|urinary_tract(1)	15						TGACGGCTCAGTAGTGGGTTG	0.701000											OREG0021894	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	9					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60767659	60767659	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:60767659C>T	ENST00000303375.5	+	26	4287	c.3885C>T	c.(3883-3885)tgC>tgT	p.C1295C	MRC2_ENST00000446119.2_Silent_p.C161C	NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	1295	C-type lectin 8.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GACAGCGCTGCCAGAGAGGTG	0.642000													4	16					0	0	1	0	0
PLN	5350	broad.mit.edu	37	6	118880187	118880187	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:118880187T>G	ENST00000357525.5	+	2	295	c.103T>G	c.(103-105)Ttc>Gtc	p.F35V	CEP85L_ENST00000368488.5_Intron|CEP85L_ENST00000360290.3_Intron|CEP85L_ENST00000368491.3_Intron|CEP85L_ENST00000419517.2_Intron|CEP85L_ENST00000392500.3_Intron	NM_002667.3	NP_002658.1	P26678	PPLA_HUMAN	phospholamban	35					blood circulation|regulation of calcium ion transport	integral to membrane|mitochondrial membrane|sarcoplasmic reticulum	calcium channel regulator activity|protein binding			large_intestine(1)|lung(3)	4		all_cancers(87;0.0916)|all_epithelial(87;0.131)		GBM - Glioblastoma multiforme(226;0.0325)|all cancers(137;0.154)|OV - Ovarian serous cystadenocarcinoma(136;0.176)		ATTTATCAATTTCTGTCTCAT	0.418000													26	33					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68597461	68597461	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:68597461C>T	ENST00000570495.1	+	5	1063	c.771C>T	c.(769-771)acC>acT	p.T257T	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000563169.2_Silent_p.T257T|ZFP90_ENST00000398253.2_Silent_p.T257T			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	257					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		ATGAATGTACCGACTGTGGGA	0.428000													42	64					0	0	1	0	0
ZNF286B	729288	broad.mit.edu	37	17	18566346	18566346	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18566346T>C	ENST00000545289.1	-	5	723	c.473A>G	c.(472-474)gAa>gGa	p.E158G		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	158					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						ATTTTCACATTCAAGGGCTGC	0.403000													4	79					0	0	1	0	0
SLC26A11	284129	broad.mit.edu	37	17	78197133	78197133	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78197133C>T	ENST00000361193.3	+	5	790	c.510C>T	c.(508-510)atC>atT	p.I170I	SLC26A11_ENST00000572725.1_Silent_p.I170I|SLC26A11_ENST00000411502.3_Silent_p.I170I|SLC26A11_ENST00000546047.2_Silent_p.I170I	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	170						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TTGGACAGATCAAGGTAGGCA	0.617000													5	9					0	0	1	0	0
NFYC	4802	broad.mit.edu	37	1	41223865	41223865	+	Missense_Mutation	SNP	G	G	A	rs139077351		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:41223865G>A	ENST00000372652.1	+	6	728	c.460G>A	c.(460-462)Gct>Act	p.A154T	NFYC_ENST00000440226.3_Missense_Mutation_p.A154T|NFYC_ENST00000427410.2_Missense_Mutation_p.A116T|NFYC_ENST00000425457.2_Missense_Mutation_p.A154T|NFYC_ENST00000372651.1_Missense_Mutation_p.A154T|NFYC_ENST00000372653.1_Missense_Mutation_p.A154T|NFYC_ENST00000372654.1_Missense_Mutation_p.A154T|NFYC_ENST00000308733.5_Missense_Mutation_p.A154T|NFYC_ENST00000456393.2_Missense_Mutation_p.A154T|NFYC_ENST00000447388.3_Missense_Mutation_p.A154T			Q13952	NFYC_HUMAN	nuclear transcription factor Y, gamma	154					protein folding|regulation of transcription from RNA polymerase II promoter	CCAAT-binding factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)|skin(2)	15	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.72e-17)			GCAACCCACCGCTGTCCAAGT	0.612000													12	15					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155157215	155157215	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:155157215G>T	ENST00000357232.3	-	25	7223	c.7224C>A	c.(7222-7224)tcC>tcA	p.S2408S		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2408	Cadherin 21.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AGACCACTAAGGAGGCAGTTG	0.413000													39	54					2.52637e-11	2.71738e-11	1	1	0
WWP2	11060	broad.mit.edu	37	16	69965459	69965459	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:69965459G>A	ENST00000359154.2	+	15	1670	c.1569G>A	c.(1567-1569)acG>acA	p.T523T	WWP2_ENST00000356003.2_Silent_p.T523T|WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000542271.1_Silent_p.T407T|WWP2_ENST00000568684.1_Silent_p.T84T|WWP2_ENST00000448661.1_Silent_p.T523T	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	523					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCAGGCAGACGCTTTTCGAAG	0.507000													46	38					0	0	1	0	0
AKR1E2	83592	broad.mit.edu	37	10	4875568	4875568	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:4875568C>A	ENST00000298375.7	+	3	305	c.234C>A	c.(232-234)tcC>tcA	p.S78S	AKR1E2_ENST00000532248.1_Silent_p.S78S|AKR1E2_ENST00000525281.1_Intron|AKR1E2_ENST00000345253.5_Silent_p.S78S|AKR1E2_ENST00000334019.4_Silent_p.S78S	NM_001040177.1	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	78						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						ATAAGAAGTCCTTGGTGGAAA	0.537000													35	55					1.59932e-28	1.79037e-28	1	1	0
AHDC1	27245	broad.mit.edu	37	1	27874390	27874390	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:27874390G>A	ENST00000374011.2	-	6	5205	c.4237C>T	c.(4237-4239)Cgg>Tgg	p.R1413W	AHDC1_ENST00000247087.5_Missense_Mutation_p.R1413W|AHDC1_ENST00000482400.2_Intron	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1413							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GGCGGTGGCCGCAGCTCTTCC	0.682000													33	49					0	0	1	0	0
GMPPB	29925	broad.mit.edu	37	3	49760429	49760429	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49760429G>A	ENST00000480687.1	-	5	494	c.378C>T	c.(376-378)caC>caT	p.H126H	AMIGO3_ENST00000535833.1_5'UTR|GMPPB_ENST00000308388.6_Silent_p.H126H|GMPPB_ENST00000308375.6_Silent_p.H126H			Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B	126			H -> D (in dbSNP:rs34345884).		dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCTGGCCATGGTGCCGGTGGA	0.582000													4	27					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	853455	853455	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:853455C>T	ENST00000314167.4	-	24	3332	c.3222G>A	c.(3220-3222)tgG>tgA	p.W1074*	GAK_ENST00000511163.1_Nonsense_Mutation_p.W995*|GAK_ENST00000509566.1_5'UTR	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	1074					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GAGACTTGGTCCAGCTGGCCT	0.612000													18	33					0	0	1	0	0
RASIP1	54922	broad.mit.edu	37	19	49238616	49238616	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49238616T>C	ENST00000222145.4	-	4	1220	c.1016A>G	c.(1015-1017)cAg>cGg	p.Q339R	RASIP1_ENST00000594232.1_5'UTR	NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	339					signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		CCGCTCCTGCTGCCGCCGCCG	0.657000													8	12					0	0	1	0	0
RNF38	152006	broad.mit.edu	37	9	36351115	36351115	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:36351115G>A	ENST00000357058.3	-	9	1617	c.1011C>T	c.(1009-1011)taC>taT	p.Y337Y	RNF38_ENST00000259605.6_Silent_p.Y420Y|RNF38_ENST00000377885.2_Silent_p.Y337Y|RNF38_ENST00000353739.4_Silent_p.Y370Y|RNF38_ENST00000350199.4_Silent_p.Y337Y|RNF38_ENST00000377877.4_Silent_p.Y344Y	NM_194328.2	NP_919309.1	Q9H0F5	RNF38_HUMAN	ring finger protein 38	420	Pro-rich.						zinc ion binding			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(1)|lung(3)|stomach(1)	11			STAD - Stomach adenocarcinoma(86;0.228)			TACTAACCTCGTAATTTTCTA	0.383000													5	7					0	0	1	0	0
ZNF34	80778	broad.mit.edu	37	8	145998963	145998963	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145998963G>A	ENST00000429371.2	-	6	1461	c.1308C>T	c.(1306-1308)agC>agT	p.S436S	ZNF34_ENST00000343459.4_Silent_p.S457S	NM_030580.3	NP_085057.3	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S457R(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		GTGTGCTTTGGCTGAAAACTT	0.488000													9	32					0	0	1	0	0
ICAM2	3384	broad.mit.edu	37	17	62081096	62081096	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62081096C>T	ENST00000412356.1	-	5	911	c.557G>A	c.(556-558)cGc>cAc	p.R186H	ICAM2_ENST00000581417.1_5'UTR|C17orf72_ENST00000412177.1_3'UTR|ICAM2_ENST00000578892.1_Missense_Mutation_p.R162H|ICAM2_ENST00000578379.1_Missense_Mutation_p.R85H|ICAM2_ENST00000449662.2_Missense_Mutation_p.R186H|ICAM2_ENST00000418105.1_Missense_Mutation_p.R186H|ICAM2_ENST00000579788.1_Missense_Mutation_p.R186H|ICAM2_ENST00000579687.1_Missense_Mutation_p.R186H	NM_001099786.1	NP_001093256.1	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2	186	Ig-like C2-type 2.				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			large_intestine(1)|lung(2)|ovary(1)|skin(2)	6						GGAGAAGTTGCGGTGGCCATC	0.572000													22	20					0	0	1	0	0
NUPL1	9818	broad.mit.edu	37	13	25887831	25887831	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:25887831G>A	ENST00000463407.1	+	5	659	c.516G>A	c.(514-516)ggG>ggA	p.G172G	NUPL1_ENST00000381736.3_Silent_p.G172G|NUPL1_ENST00000381718.3_Silent_p.G160G|NUPL1_ENST00000466694.1_3'UTR			Q9BVL2	NUPL1_HUMAN	nucleoporin like 1	172	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore				breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|stomach(1)|urinary_tract(1)	16		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		TCTCTTTAGGGGGAGCCTTAG	0.388000													22	64					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36595189	36595189	+	Missense_Mutation	SNP	G	G	A	rs4151026		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:36595189G>A	ENST00000299440.5	+	2	447	c.335G>A	c.(334-336)cGc>cAc	p.R112H		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	112	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding	p.R112L(1)		NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				CATCTCTGCCGCATCTGTGGG	0.453000									Familial Hemophagocytic Lymphohistiocytosis				27	36					0	0	1	0	0
TRAF7	84231	broad.mit.edu	37	16	2225572	2225572	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2225572C>T	ENST00000326181.6	+	17	1707	c.1575C>T	c.(1573-1575)gcC>gcT	p.A525A		NM_032271.2	NP_115647.2	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	525					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	23						GGGTGCGGGCCCTGGTGGCTG	0.622000													16	28					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62397885	62397885	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62397885C>A	ENST00000346178.4	-	13	1560	c.1545G>T	c.(1543-1545)cgG>cgT	p.R515R	GANAB_ENST00000534779.1_Silent_p.R401R|GANAB_ENST00000356638.3_Silent_p.R493R|GANAB_ENST00000540933.1_Silent_p.R396R	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	493					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding	p.R493R(1)		central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						CAGAGCCATCCCGGGTTTTAA	0.597000													16	17					2.23348e-06	2.32236e-06	1	1	0
PER2	8864	broad.mit.edu	37	2	239167146	239167146	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:239167146G>A	ENST00000254657.3	-	15	2046	c.1767C>T	c.(1765-1767)agC>agT	p.S589S	PER2_ENST00000254658.3_3'UTR	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	589	CSNK1E binding domain (By similarity).				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		ACCTGATGACGCTGTCCAAGC	0.582000													17	26					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93552392	93552392	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:93552392G>A	ENST00000394196.4	+	35	5499	c.4431G>A	c.(4429-4431)agG>agA	p.R1477R	CHD2_ENST00000557381.1_Silent_p.R1477R	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1477					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AGAGGATGAGGCCCGTGAAAA	0.478000													4	9					0	0	1	0	0
MPST	4357	broad.mit.edu	37	22	37420591	37420591	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37420591G>A	ENST00000397225.2	+	2	1250	c.335G>A	c.(334-336)cGc>cAc	p.R112H	MPST_ENST00000401419.3_Missense_Mutation_p.R112H|MPST_ENST00000341116.3_Missense_Mutation_p.R112H|MPST_ENST00000404802.3_Missense_Mutation_p.R112H|MPST_ENST00000429360.2_Missense_Mutation_p.R112H|MPST_ENST00000397129.1_Missense_Mutation_p.R132H|MPST_ENST00000404393.1_Missense_Mutation_p.R112H			P25325	THTM_HUMAN	mercaptopyruvate sulfurtransferase	112	Rhodanese 1.				cyanate catabolic process|response to toxin		3-mercaptopyruvate sulfurtransferase activity|thiosulfate sulfurtransferase activity			central_nervous_system(2)|kidney(1)|lung(2)|prostate(1)|skin(1)	7						TCCGCCCCGCGCGTCTGGTGG	0.716000													4	7					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681353	55681353	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55681353T>C	ENST00000344514.1	-	1	705	c.706A>G	c.(706-708)Aaa>Gaa	p.K236E		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GAGAGAGCTTTGAACCTCCCC	0.408000													8	32					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129188250	129188250	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:129188250G>A	ENST00000296266.3	+	10	1151	c.959G>A	c.(958-960)aGt>aAt	p.S320N	IFT122_ENST00000349441.2_Missense_Mutation_p.S158N|IFT122_ENST00000347300.2_Missense_Mutation_p.S210N|IFT122_ENST00000348417.2_Missense_Mutation_p.S269N|IFT122_ENST00000440957.2_Missense_Mutation_p.S60N|IFT122_ENST00000504021.1_Missense_Mutation_p.S163N|IFT122_ENST00000507564.1_Missense_Mutation_p.S261N|IFT122_ENST00000431818.2_Missense_Mutation_p.S119N	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	269					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TACCAGCTGAGTGGAAAACAG	0.388000													27	41					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30680817	30680817	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30680817G>A	ENST00000376406.3	-	5	1549	c.902C>T	c.(901-903)aCa>aTa	p.T301I	MDC1_ENST00000376405.2_Missense_Mutation_p.T301I|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	301	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						ATCCACATCTGTGTCACTGTC	0.552000								Other conserved DNA damage response genes					27	50					0	0	1	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124241427	124241427	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:124241427G>A	ENST00000330342.3	+	19	2607	c.2359G>A	c.(2359-2361)Gtc>Atc	p.V787I	ATP6V0A2_ENST00000543687.1_3'UTR|ATP6V0A2_ENST00000544833.1_Missense_Mutation_p.V69I	NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	787					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		CACCTATGGCGTCTTGCTACT	0.552000													42	51					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58080667	58080667	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58080667G>A	ENST00000357272.4	+	5	1057	c.892G>A	c.(892-894)Ggg>Agg	p.G298R	FLNB_ENST00000490882.1_Missense_Mutation_p.G298R|FLNB_ENST00000295956.4_Missense_Mutation_p.G298R|FLNB_ENST00000493452.1_Missense_Mutation_p.G129R|FLNB_ENST00000358537.3_Missense_Mutation_p.G298R|FLNB_ENST00000429972.2_Missense_Mutation_p.G298R|FLNB_ENST00000419752.2_Missense_Mutation_p.G129R|FLNB_ENST00000348383.5_Missense_Mutation_p.G298R			O75369	FLNB_HUMAN	filamin B, beta	298					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGACCCAGAAGGGAACAAAGA	0.557000													22	51					0	0	1	0	0
CYTL1	54360	broad.mit.edu	37	4	5016936	5016936	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:5016936C>T	ENST00000307746.4	-	4	379	c.353G>A	c.(352-354)tGc>tAc	p.C118Y		NM_018659.2	NP_061129.1	Q9NRR1	CYTL1_HUMAN	cytokine-like 1	118					signal transduction	extracellular space|soluble fraction	receptor binding			breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		CAAGGCATTGCAGTCATCCAA	0.478000													29	51					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90179785	90179785	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:90179785C>T	ENST00000370454.4	+	3	1911	c.1656C>T	c.(1654-1656)aaC>aaT	p.N552N	RP11-302M6.4_ENST00000370453.5_Intron|LRRC8C_ENST00000479252.1_Intron	NM_032270.4	NP_115646.2	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member C	552						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		TCAAAAGCAACGTTTCCAAAA	0.428000													25	51					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82595421	82595421	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:82595421C>T	ENST00000423517.2	-	4	4020	c.3683G>A	c.(3682-3684)cGt>cAt	p.R1228H	PCLO_ENST00000333891.8_Missense_Mutation_p.R1228H	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1167					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTCTTCAGAACGTATCTTTTC	0.393000													65	80					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64527080	64527080	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:64527080G>A	ENST00000498707.1	-	35	5645	c.5303C>T	c.(5302-5304)gCg>gTg	p.A1768V	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.A1740V	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1768	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GTGCATCCCCGCACAGAATAT	0.463000													30	44					0	0	1	0	0
MIR524	0	broad.mit.edu	37	19	54214334	54214334	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54214334G>A	ENST00000385242.1	+	0	79					NR_030200.1																						GGAGTGTTACGGTTTGAGAAA	0.463000													10	81					0	0	1	0	0
PPM1A	5494	broad.mit.edu	37	14	60750032	60750032	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:60750032G>C	ENST00000395076.4	+	2	1041	c.611G>C	c.(610-612)tGt>tCt	p.C204S	PPM1A_ENST00000325642.3_Missense_Mutation_p.C277S|PPM1A_ENST00000529574.1_Missense_Mutation_p.C204S|PPM1A_ENST00000325658.3_Missense_Mutation_p.C204S	NM_021003.4	NP_066283.1	P35813	PPM1A_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1A	204					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			cervix(1)|endometrium(1)|large_intestine(8)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.046)		GATTACAAATGTGTCCATGGA	0.448000													32	32					0	0	1	0	0
PTTG1	9232	broad.mit.edu	37	5	159854762	159854762	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:159854762G>A	ENST00000393964.1	+	4	814	c.411G>A	c.(409-411)gcG>gcA	p.A137A	PTTG1_ENST00000519287.1_3'UTR|PTTG1_ENST00000352433.5_Silent_p.A137A|PTTG1_ENST00000520452.1_Silent_p.A137A			O95997	PTTG1_HUMAN	pituitary tumor-transforming 1	137					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|chromosome organization|chromosome segregation|DNA repair|mitosis|spermatogenesis|transcription from RNA polymerase II promoter	cytosol|nucleus	cysteine-type endopeptidase inhibitor activity|sequence-specific DNA binding transcription factor activity|SH3 domain binding			breast(1)|large_intestine(1)|lung(4)	6	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.00219)|Epithelial(171;0.00348)|all cancers(165;0.0104)		ACCAGATTGCGCACCTCCCCT	0.522000													30	39					0	0	1	0	0
DDR2	4921	broad.mit.edu	37	1	162725543	162725543	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:162725543G>A	ENST00000367922.2	+	8	1093	c.655G>A	c.(655-657)Gga>Aga	p.G219R	DDR2_ENST00000367921.3_Missense_Mutation_p.G219R	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	219					cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TGTCTATGATGGAGCTGTTGG	0.398000													55	78					0	0	1	0	0
CDT1	81620	broad.mit.edu	37	16	88873803	88873803	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:88873803G>A	ENST00000301019.4	+	9	2009	c.1390G>A	c.(1390-1392)Gtc>Atc	p.V464I		NM_030928.3	NP_112190.2	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor 1	464					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(3)	7				BRCA - Breast invasive adenocarcinoma(80;0.0476)		GCTGCGGAGCGTCTTTGTGTC	0.652000													8	39					0	0	1	0	0
CNPY4	245812	broad.mit.edu	37	7	99722481	99722481	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99722481C>T	ENST00000262932.3	+	6	849	c.717C>T	c.(715-717)agC>agT	p.S239S	CNPY4_ENST00000480692.1_3'UTR|RP11-506M12.1_ENST00000494221.1_RNA	NM_152755.1	NP_689968.1	Q8N129	CNPY4_HUMAN	canopy FGF signaling regulator 4	239						extracellular region				breast(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGACAGGAAGCCACCCCAAAC	0.557000													8	46					0	0	1	0	0
DAAM2	23500	broad.mit.edu	37	6	39864692	39864692	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:39864692G>A	ENST00000538976.1	+	20	2628	c.2446G>A	c.(2446-2448)Ggc>Agc	p.G816S	RP11-61I13.3_ENST00000606829.1_RNA|RP11-61I13.3_ENST00000430595.1_RNA|DAAM2_ENST00000398904.2_Missense_Mutation_p.G816S|RP11-61I13.3_ENST00000420293.1_RNA|DAAM2_ENST00000274867.4_Missense_Mutation_p.G816S	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	816	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					GCAGCGTGGGGGCGCCTACGG	0.612000													12	13					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74019483	74019483	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74019483C>T	ENST00000301607.3	-	4	623	c.370G>A	c.(370-372)Gag>Aag	p.E124K	EVPL_ENST00000586740.1_Missense_Mutation_p.E124K	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	124	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GTCACCCGCTCGTGCAGCTGC	0.677000													30	27					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42315709	42315709	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:42315709G>T	ENST00000217026.4	+	5	624	c.497G>T	c.(496-498)gGg>gTg	p.G166V	MYBL2_ENST00000396863.4_Missense_Mutation_p.G142V	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	166	HTH myb-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ATGTTGCCAGGGAGGTAAGCT	0.617000													11	10					2.68362e-12	2.90084e-12	1	1	0
RNF14	9604	broad.mit.edu	37	5	141359810	141359810	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:141359810G>A	ENST00000394520.2	+	6	1266	c.957G>A	c.(955-957)atG>atA	p.M319I	RNF14_ENST00000394514.2_Missense_Mutation_p.M193I|RNF14_ENST00000394519.1_Missense_Mutation_p.M319I|RNF14_ENST00000347642.3_Missense_Mutation_p.M319I|RNF14_ENST00000540015.1_Intron|AC005740.5_ENST00000520882.1_RNA|RNF14_ENST00000356143.1_Missense_Mutation_p.M319I|RNF14_ENST00000394515.3_Missense_Mutation_p.M143I	NM_001201365.1|NM_004290.4	NP_001188294.1|NP_004281.1	Q9UBS8	RNF14_HUMAN	ring finger protein 14	319					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		TGCCTGTGATGCAGGAACCTG	0.562000													37	65					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7907408	7907408	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7907408C>T	ENST00000254854.4	+	3	1110	c.960C>T	c.(958-960)agC>agT	p.S320S		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	320					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				CTGAAGGCAGCGTGCTGGACA	0.682000													18	17					0	0	1	0	0
C15orf54	400360	broad.mit.edu	37	15	39544513	39544513	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:39544513G>A	ENST00000318578.3	+	2	545	c.177G>A	c.(175-177)acG>acA	p.T59T	RP11-624L4.1_ENST00000560484.1_RNA|C15orf54_ENST00000561223.1_Silent_p.T59T|RP11-624L4.1_ENST00000561058.1_RNA|RP11-624L4.1_ENST00000558209.1_RNA	NM_207445.2	NP_997328.1	Q8N8G6	CO054_HUMAN	chromosome 15 open reading frame 54	59			T -> M (in dbSNP:rs11853050).							NS(1)|haematopoietic_and_lymphoid_tissue(2)|lung(2)	5		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		ATCACATGACGGAGCTCCCTC	0.438000													5	199					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86198613	86198613	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:86198613C>T	ENST00000361228.3	-	2	1543	c.1175G>A	c.(1174-1176)gGg>gAg	p.G392E		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	392					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AGGAATCTCCCCATTGCTACT	0.443000													6	126					0	0	1	0	0
GIGYF1	64599	broad.mit.edu	37	7	100279357	100279357	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100279357G>A	ENST00000275732.5	-	24	4302	c.3093C>T	c.(3091-3093)agC>agT	p.S1031S		NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	1031										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					AGTCATCCACGCTCTCGATCT	0.677000													8	10					0	0	1	0	0
LY6D	8581	broad.mit.edu	37	8	143866833	143866833	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:143866833G>A	ENST00000301263.4	-	3	266	c.191C>T	c.(190-192)gCg>gTg	p.A64V	RP11-706C16.8_ENST00000510610.2_RNA|LY6D_ENST00000518434.1_5'UTR	NM_003695.2	NP_003686.1	Q14210	LY6D_HUMAN	lymphocyte antigen 6 complex, locus D	64	UPAR/Ly6.				cell adhesion	anchored to membrane|membrane fraction|plasma membrane	protein binding			large_intestine(1)|lung(3)|prostate(1)	5	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GCACGACTCCGCACAGTCCTT	0.642000													7	16					0	0	1	0	0
UBXN6	80700	broad.mit.edu	37	19	4454004	4454004	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4454004G>A	ENST00000301281.6	-	2	294	c.170C>T	c.(169-171)gCt>gTt	p.A57V	UBXN6_ENST00000394765.3_Missense_Mutation_p.A4V	NM_025241.2	NP_079517.1	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	57						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	12						TAGGGCGGCAGCGGCTGCCAT	0.682000													36	61					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713334	142713334	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:142713334C>A	ENST00000369381.2	-	0	1271																											CTGAGAGTATCTCTTTTCTTA	0.328000													13	17					6.81908e-15	7.45441e-15	1	1	0
RIMKLA	284716	broad.mit.edu	37	1	42880423	42880423	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:42880423G>A	ENST00000431473.3	+	5	1083	c.954G>A	c.(952-954)tcG>tcA	p.S318S		NM_173642.3	NP_775913.2	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family member A	318					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						CAGGACTGTCGAGTCCAAGGG	0.522000													21	28					0	0	1	0	0
FPGT-TNNI3K	0	broad.mit.edu	37	1	74819813	74819813	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:74819813G>T	ENST00000370895.1	+	13	1515	c.1480_splice	c.e13+1	p.G494_splice	TNNI3K_ENST00000370891.2_Splice_Site_p.G494_splice|RP11-439H8.4_ENST00000415549.2_RNA|FPGT-TNNI3K_ENST00000370899.3_Splice_Site_p.G494_splice|FPGT-TNNI3K_ENST00000557284.1_Splice_Site_p.G494_splice|TNNI3K_ENST00000326637.3_Splice_Site_p.G393_splice			Q59H18	TNI3K_HUMAN		393	Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										TTATGAAAAAGGTATATTTTT	0.378000													13	65					1.5739e-10	1.6844e-10	1	1	0
AADACL4	343066	broad.mit.edu	37	1	12721814	12721814	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12721814G>A	ENST00000376221.1	+	3	398	c.398G>A	c.(397-399)gGc>gAc	p.G133D		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	133						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TGTTACCATGGCCTGTGCAAT	0.522000													38	72					0	0	1	0	0
ALX4	60529	broad.mit.edu	37	11	44286443	44286443	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:44286443C>A	ENST00000329255.3	-	4	1300	c.1197G>T	c.(1195-1197)aaG>aaT	p.K399N		NM_021926.3	NP_068745.2	Q9H161	ALX4_HUMAN	ALX homeobox 4	399					hair follicle development					central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	16						GCTCCTTGGCCTTCATGCGGA	0.667000													6	25					0.000274275	0.000279654	1	1	0
PIK3R6	146850	broad.mit.edu	37	17	8732104	8732104	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8732104C>T	ENST00000311434.9	-	11	1332	c.1093G>A	c.(1093-1095)Ggg>Agg	p.G365R	PIK3R6_ENST00000434064.2_5'UTR	NM_001010855.2	NP_001010855.1	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	365					platelet activation	cytosol											CGCTGCAGCCCGGCTCGCTCC	0.677000													9	7					0	0	1	0	0
RSPRY1	89970	broad.mit.edu	37	16	57265194	57265194	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57265194G>A	ENST00000537866.1	+	13	2365	c.1492G>A	c.(1492-1494)Gcc>Acc	p.A498T	RSPRY1_ENST00000563073.1_3'UTR|RSPRY1_ENST00000394420.4_Missense_Mutation_p.A498T			Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	498						extracellular region	zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|urinary_tract(3)	27						TAATGACTACGCCTTCCTAAC	0.358000													19	39					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53344567	53344567	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53344567T>C	ENST00000595646.1	-	4	1100	c.980A>G	c.(979-981)tAc>tGc	p.Y327C	ZNF468_ENST00000390651.4_Missense_Mutation_p.Y274C|ZNF468_ENST00000396409.4_Missense_Mutation_p.Y274C|ZNF28_ENST00000594602.1_Intron|ZNF468_ENST00000243639.4_3'UTR			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	327					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		CTTACATTTGTATGGTTTCTC	0.363000													4	120					0	0	1	0	0
BMP7	655	broad.mit.edu	37	20	55746114	55746114	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:55746114C>T	ENST00000395863.3	-	7	1702	c.1197G>A	c.(1195-1197)acG>acA	p.T399T	BMP7_ENST00000395864.3_Silent_p.T333T|BMP7_ENST00000460817.1_5'UTR	NM_001719.2	NP_001710.1	P18075	BMP7_HUMAN	bone morphogenetic protein 7	399					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			CATTGAGCTGCGTGGGCGCAC	0.562000													5	13					0	0	1	0	0
GREM1	26585	broad.mit.edu	37	15	33023238	33023238	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:33023238G>A	ENST00000300177.4	+	2	536	c.347G>A	c.(346-348)cGc>cAc	p.R116H	GREM1_ENST00000322805.4_Missense_Mutation_p.R75H|GREM1_ENST00000560830.1_Missense_Mutation_p.R75H|GREM1_ENST00000560677.1_3'UTR	NM_001191322.1|NM_001191323.1|NM_013372.6	NP_001178251.1|NP_001178252.1|NP_037504.1	O60565	GREM1_HUMAN	gremlin 1, DAN family BMP antagonist	116	CTCK.				negative regulation of BMP signaling pathway|nervous system development|regulation of epithelial to mesenchymal transition	extracellular space	cytokine activity	p.R116H(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(6)|prostate(1)	10		all_lung(180;1.49e-09)		all cancers(64;2.97e-18)|Epithelial(43;3.15e-12)|GBM - Glioblastoma multiforme(186;2.32e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0107)		ATCATCAACCGCTTCTGTTAC	0.542000													9	20					0	0	1	0	0
CORO7	79585	broad.mit.edu	37	16	4411454	4411454	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4411454C>T	ENST00000251166.4	-	17	1740	c.1595G>A	c.(1594-1596)cGc>cAc	p.R532H	CORO7_ENST00000574025.1_Missense_Mutation_p.R447H|CORO7_ENST00000539968.1_Missense_Mutation_p.R312H|CORO7_ENST00000537233.2_Missense_Mutation_p.R514H|CORO7-PAM16_ENST00000572467.1_Missense_Mutation_p.R532H|CORO7_ENST00000423908.2_3'UTR	NM_024535.4	NP_078811.3			coronin 7											breast(3)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|prostate(2)|skin(2)|urinary_tract(2)	23						GTCGGGCAGGCGGCCAGGCTT	0.667000													11	12					0	0	1	0	0
BIN3	55909	broad.mit.edu	37	8	22481548	22481548	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22481548C>T	ENST00000276416.6	-	8	563	c.495G>A	c.(493-495)ctG>ctA	p.L165L	BIN3_ENST00000399977.4_Silent_p.L117L|BIN3_ENST00000519335.1_5'UTR|BIN3_ENST00000519513.1_Silent_p.L111L	NM_018688.4	NP_061158.1	Q9NQY0	BIN3_HUMAN	bridging integrator 3	165	BAR.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	9		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		GCACAGGCCGCAGCTCCTCTC	0.617000													13	14					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59211466	59211466	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:59211466G>T	ENST00000302030.2	+	1	850	c.825G>T	c.(823-825)aaG>aaT	p.K275N		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						GCAGGGACAAGGTGGTGTCTG	0.512000													60	74					2.22609e-26	2.48765e-26	1	1	0
HK1	3098	broad.mit.edu	37	10	71158559	71158559	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:71158559G>A	ENST00000448642.2	+	22	3078	c.2689G>A	c.(2689-2691)Ggg>Agg	p.G897R	HK1_ENST00000404387.2_Missense_Mutation_p.G866R|HK1_ENST00000298649.3_Missense_Mutation_p.G861R|HK1_ENST00000360289.2_Missense_Mutation_p.G850R|HK1_ENST00000359426.6_Missense_Mutation_p.G862R			P19367	HXK1_HUMAN	hexokinase 1	862	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						GGGAGTGGACGGGACACTCTA	0.587000													16	27					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135204624	135204624	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:135204624G>T	ENST00000372169.2	-	10	2543	c.2361C>A	c.(2359-2361)atC>atA	p.I787I	SETX_ENST00000224140.5_Silent_p.I787I|SETX_ENST00000393220.1_Silent_p.I787I			Q7Z333	SETX_HUMAN	senataxin	787					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ACTTTGCACAGATTTCATCTT	0.328000													21	43					8.34094e-07	8.70022e-07	1	1	0
CEP72	55722	broad.mit.edu	37	5	620335	620335	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:620335G>A	ENST00000264935.5	+	3	452	c.362G>A	c.(361-363)cGc>cAc	p.R121H	CEP72_ENST00000444221.1_Missense_Mutation_p.R121H	NM_018140.3	NP_060610.2	Q9P209	CEP72_HUMAN	centrosomal protein 72kDa	121	LRRCT.				G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(5)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	20			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			CCTGACTACCGCCTTTTTGTT	0.602000													27	31					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79028741	79028741	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:79028741C>T	ENST00000446378.2	+	2	4184	c.4153C>T	c.(4153-4155)Cgt>Tgt	p.R1385C		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1385						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TCCTGTAGATCGTCCAGTCTT	0.398000													7	14					0	0	1	0	0
ABTB1	80325	broad.mit.edu	37	3	127395843	127395843	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:127395843A>G	ENST00000468137.1	+	6	750	c.134A>G	c.(133-135)gAc>gGc	p.D45G	ABTB1_ENST00000232744.8_Missense_Mutation_p.D187G|ABTB1_ENST00000453791.2_Missense_Mutation_p.D45G|ABTB1_ENST00000393363.3_Missense_Mutation_p.D45G			Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	187						cytoplasm|nucleolus|plasma membrane	translation elongation factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	10						CATGTGAGTGACTGTGAGCGC	0.622000													10	10					0	0	1	0	0
ZMYM1	79830	broad.mit.edu	37	1	35569964	35569964	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:35569964G>A	ENST00000373330.1	+	6	662	c.488G>A	c.(487-489)tGc>tAc	p.C163Y	ZMYM1_ENST00000359858.4_Missense_Mutation_p.C163Y|ZMYM1_ENST00000373329.1_3'UTR			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	163						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAAACTTTTTGCAGCCTATCT	0.348000													38	28					0	0	1	0	0
HNF1B	6928	broad.mit.edu	37	17	36091778	36091778	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36091778C>T	ENST00000225893.4	-	4	1214	c.853G>A	c.(853-855)Ggc>Agc	p.G285S	HNF1B_ENST00000561193.1_Missense_Mutation_p.G259S|HNF1B_ENST00000560016.1_Missense_Mutation_p.G285S|HNF1B_ENST00000427275.2_Missense_Mutation_p.G259S	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	285			G -> D (in RCAD).		endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GAGCCCAGGCCGTGGGCTTTG	0.612000													19	47					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89654413	89654413	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:89654413C>T	ENST00000355754.6	-	8	1359	c.1262G>A	c.(1261-1263)tGc>tAc	p.C421Y		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	421						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		CTCAGCCTGGCAATATTTGGC	0.428000													71	99					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43484051	43484051	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:43484051C>T	ENST00000282041.5	-	25	4395	c.4361G>A	c.(4360-4362)cGc>cAc	p.R1454H	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	1454					autophagy			p.R1454H(1)		NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						ATGATAGATGCGCTCCATGTT	0.443000													14	26					0	0	1	0	0
PIBF1	10464	broad.mit.edu	37	13	73572995	73572995	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:73572995G>A	ENST00000326291.6	+	17	2423	c.2085G>A	c.(2083-2085)atG>atA	p.M695I	PIBF1_ENST00000489922.1_3'UTR	NM_006346.2	NP_006337.2	Q8WXW3	PIBF1_HUMAN	progesterone immunomodulatory binding factor 1	695						centrosome				breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		TCGTTAAGATGCATAGTAAAC	0.343000													20	10					0	0	1	0	0
KCNAB1	7881	broad.mit.edu	37	3	156009906	156009906	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:156009906C>T	ENST00000302490.8	+	1	1081	c.210C>T	c.(208-210)ggC>ggT	p.G70G	KCNAB1_ENST00000490337.1_Intron|KCNAB1_ENST00000471742.1_Intron|KCNAB1_ENST00000389634.5_Silent_p.G70G|KCNAB1_ENST00000389636.5_Intron	NM_172159.3	NP_751891.1	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	88						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AGCAGACTGGCATGAAATATA	0.517000													15	31					0	0	1	0	0
SRPK1	6732	broad.mit.edu	37	6	35840373	35840373	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:35840373G>A	ENST00000373825.2	-	8	1003	c.718C>T	c.(718-720)Cga>Tga	p.R240*	SRPK1_ENST00000373822.1_Nonsense_Mutation_p.R133*|SRPK1_ENST00000423325.2_Nonsense_Mutation_p.R224*			Q96SB4	SRPK1_HUMAN	SRSF protein kinase 1	240	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(10)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21						GCTCCAGATCGCTGCCATTCT	0.428000													4	12					0	0	1	0	0
SPATA32	124783	broad.mit.edu	37	17	43333080	43333080	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:43333080G>T	ENST00000543122.1	-	6	1187	c.406C>A	c.(406-408)Ctc>Atc	p.L136I	MAP3K14-AS1_ENST00000585346.1_RNA|MAP3K14-AS1_ENST00000588504.1_RNA|MAP3K14-AS1_ENST00000592422.1_RNA|MAP3K14-AS1_ENST00000591263.1_RNA|SPATA32_ENST00000331780.4_Missense_Mutation_p.L157I|MAP3K14-AS1_ENST00000590100.1_RNA|MAP3K14-AS1_ENST00000588698.1_RNA|MAP3K14-AS1_ENST00000588160.1_RNA					spermatogenesis associated 32																		GCCCAGAAGAGGTGCTTGGAG	0.577000													6	60					3.59834e-05	3.7043e-05	1	1	0
TUFM	7284	broad.mit.edu	37	16	28854382	28854382	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:28854382G>A	ENST00000313511.3	-	10	1420	c.1282C>T	c.(1282-1284)Cga>Tga	p.R428*		NM_003321.4	NP_003312.3	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	425						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13						TTGCCATCTCGCAGGGTGAAA	0.532000													31	35					0	0	1	0	0
OLFM1	10439	broad.mit.edu	37	9	138011583	138011583	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:138011583C>T	ENST00000252854.4	+	6	1150	c.963C>T	c.(961-963)gcC>gcT	p.A321A	OLFM1_ENST00000371793.3_Silent_p.A339A|OLFM1_ENST00000371796.3_Silent_p.A312A	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	339	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		TGGACTATGCCGGTTACAACA	0.552000													13	20					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34091237	34091237	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:34091237C>T	ENST00000397527.1	+	30	5760	c.5040C>T	c.(5038-5040)atC>atT	p.I1680I	CEP250_ENST00000342580.4_Silent_p.I1624I	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1680	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			AGACCAAGATCCTGGAGGAGG	0.582000													28	54					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170235671	170235671	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:170235671C>A	ENST00000518525.1	+	9	1211	c.747C>A	c.(745-747)acC>acA	p.T249T	GABRP_ENST00000519385.1_Silent_p.T249T|GABRP_ENST00000519598.1_Silent_p.T249T|GABRP_ENST00000265294.4_Silent_p.T249T			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	249						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTTTGGAAACCTACGTTCCTT	0.428000													21	29					1.96292e-10	2.09789e-10	1	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125660566	125660566	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:125660566C>T	ENST00000431078.1	+	22	3905	c.3541C>T	c.(3541-3543)Cgc>Tgc	p.R1181C		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1181	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding	p.R1181S(1)		NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGCTGCCCTGCGCCATGCCAC	0.537000													6	16					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41905902	41905902	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:41905902C>A	ENST00000396930.3	-	3	1137	c.594G>T	c.(592-594)aaG>aaT	p.K198N	KAT6A_ENST00000265713.2_Missense_Mutation_p.K198N|KAT6A_ENST00000406337.1_Missense_Mutation_p.K198N|KAT6A_ENST00000485568.1_Missense_Mutation_p.K198N	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	198					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TTACCTTATCCTTTTCATGTG	0.398000													25	32					1.2476e-16	1.37101e-16	1	1	0
FSCN1	6624	broad.mit.edu	37	7	5643653	5643653	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:5643653A>C	ENST00000382361.3	+	4	1385	c.1271A>C	c.(1270-1272)aAc>aCc	p.N424T	FSCN1_ENST00000340250.6_Missense_Mutation_p.N403T	NM_003088.3	NP_003079.1	Q16658	FSCN1_HUMAN	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	424					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		GGCGCCTACAACATCAAAGGC	0.647000													7	11					0	0	1	0	0
ZNF668	79759	broad.mit.edu	37	16	31075680	31075680	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31075680G>A	ENST00000538906.1	-	2	885	c.101C>T	c.(100-102)gCg>gTg	p.A34V	ZNF668_ENST00000539836.3_Missense_Mutation_p.A57V|ZNF668_ENST00000535577.1_Missense_Mutation_p.A34V|ZNF668_ENST00000394983.2_Missense_Mutation_p.A34V|ZNF668_ENST00000300849.4_Missense_Mutation_p.A34V|ZNF668_ENST00000426488.2_Missense_Mutation_p.A57V	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	34					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						TGCCCTGGGCGCGTTTGGAAA	0.647000													14	69					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89382166	89382166	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:89382166G>A	ENST00000439576.2	+	3	717	c.343G>A	c.(343-345)Gac>Aac	p.D115N	ACAN_ENST00000352105.7_Missense_Mutation_p.D115N|ACAN_ENST00000559004.1_Missense_Mutation_p.D115N|ACAN_ENST00000561243.1_Missense_Mutation_p.D115N|ACAN_ENST00000558207.1_Missense_Mutation_p.D115N	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	115					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CATCCCCAGTGACGCCACCTT	0.622000													46	56					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42643648	42643648	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:42643648C>T	ENST00000282030.5	+	6	5072	c.4776C>T	c.(4774-4776)agC>agT	p.S1592S		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	1592						nucleus	DNA binding	p.S1538S(1)|p.S1592S(1)		NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GGAGTGAGAGCGAGGTCCTTC	0.697000									Schinzel-Giedion syndrome				4	3					0	0	1	0	0
DDN	23109	broad.mit.edu	37	12	49391285	49391285	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49391285C>T	ENST00000421952.2	-	2	1395	c.1374G>A	c.(1372-1374)acG>acA	p.T458T		NM_015086.1	NP_055901.2	O94850	DEND_HUMAN	dendrin	458	Interaction with CD2AP and NPHS1 (By similarity).					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						TCACTACGCACGTGGCGTCAA	0.642000													26	33					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36755134	36755134	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:36755134G>A	ENST00000354618.5	+	5	1738	c.1514G>A	c.(1513-1515)gGc>gAc	p.G505D	THRAP3_ENST00000469141.2_Missense_Mutation_p.G505D	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	505					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAAGATCGGGGCAAGAGAAGC	0.522000			T	USP6	aneurysmal bone cysts								5	83					0	0	1	0	0
PLCD1	5333	broad.mit.edu	37	3	38050790	38050790	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38050790G>A	ENST00000463876.1	-	10	1995	c.1642C>T	c.(1642-1644)Cgt>Tgt	p.R548C	PLCD1_ENST00000334661.4_Missense_Mutation_p.R527C	NM_001130964.1	NP_001124436.1	P51178	PLCD1_HUMAN	phospholipase C, delta 1	527	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CGAAGGGCACGGTTCTCAGAG	0.587000													24	26					0	0	1	0	0
ACAP2	23527	broad.mit.edu	37	3	195028045	195028045	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195028045G>A	ENST00000326793.6	-	12	1147	c.917C>T	c.(916-918)cCg>cTg	p.P306L		NM_012287.5	NP_036419.3	Q15057	ACAP2_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	306	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	27						TACCACAGTCGGATTATCCTA	0.378000													32	47					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25263878	25263878	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:25263878G>A	ENST00000216962.4	+	13	1695	c.1585G>A	c.(1585-1587)Gag>Aag	p.E529K		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	529					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	GGTCAGTGACGAGGTGTTCAT	0.622000													17	26					0	0	1	0	0
LGI4	163175	broad.mit.edu	37	19	35617178	35617178	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35617178G>T	ENST00000392225.3	-	7	1891	c.1372C>A	c.(1372-1374)Cca>Aca	p.P458T	LGI4_ENST00000310123.3_Missense_Mutation_p.S432Y|LGI4_ENST00000493050.1_5'UTR			Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	0						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CCTCACCATGGAGTCCCCAAT	0.607000													4	4					0.00024832	0.000253518	1	1	0
MYH11	4629	broad.mit.edu	37	16	15865458	15865458	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:15865458G>A	ENST00000338282.6	-	9	1107	c.1001C>T	c.(1000-1002)gCa>gTa	p.A334V	MYH11_ENST00000576790.1_Missense_Mutation_p.A334V|MYH11_ENST00000452625.2_Missense_Mutation_p.A341V|MYH11_ENST00000396324.3_Missense_Mutation_p.A341V|MYH11_ENST00000300036.5_Missense_Mutation_p.A334V	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	334	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						ACCCATGATTGCCATGGCCTC	0.527000			T	CBFB	AML								23	34					0	0	1	0	0
C7orf60	154743	broad.mit.edu	37	7	112462157	112462157	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:112462157G>A	ENST00000297145.4	-	5	1025	c.860C>T	c.(859-861)gCt>gTt	p.A287V		NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	287										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						CATCATCATAGCATGACGGTT	0.398000													12	77					0	0	1	0	0
UBE2I	7329	broad.mit.edu	37	16	1365672	1365672	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1365672C>T	ENST00000355803.4	+	4	719	c.168C>T	c.(166-168)ggC>ggT	p.G56G	UBE2I_ENST00000397515.2_Silent_p.G56G|UBE2I_ENST00000566587.1_Silent_p.G56G|UBE2I_ENST00000325437.5_Silent_p.G56G|UBE2I_ENST00000402301.1_Silent_p.G56G|UBE2I_ENST00000397514.3_Silent_p.G56G|UBE2I_ENST00000406620.1_Silent_p.G56G|UBE2I_ENST00000403747.2_Silent_p.G56G	NM_194260.2	NP_919236.1	P63279	UBC9_HUMAN	ubiquitin-conjugating enzyme E2I	56					cell division|chromosome segregation|interspecies interaction between organisms|mitosis|negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|protein sumoylation	cytoplasm|PML body|synaptonemal complex	ATP binding|enzyme binding|ubiquitin-protein ligase activity			breast(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)	5		Hepatocellular(780;0.00369)				GGGAAGGAGGCTTGTTTAAAC	0.537000													46	83					0	0	1	0	0
PROCR	10544	broad.mit.edu	37	20	33762558	33762558	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:33762558G>A	ENST00000216968.4	+	2	206	c.124G>A	c.(124-126)Gtg>Atg	p.V42M	EDEM2_ENST00000540582.1_Intron	NM_006404.3	NP_006395.2	Q9UNN8	EPCR_HUMAN	protein C receptor, endothelial	42					antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity			breast(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	CCCCTATCACGTGTGGTACCA	0.632000													29	45					0	0	1	0	0
OR3A3	8392	broad.mit.edu	37	17	3324785	3324785	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3324785C>T	ENST00000291231.1	+	1	924	c.924C>T	c.(922-924)ggC>ggT	p.G308G		NM_012373.2	NP_036505.2	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A, member 3	308					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)	9						ATGTTCAGGGCGCTCTGTGTC	0.483000													30	27					0	0	1	0	0
MRPS9	64965	broad.mit.edu	37	2	105713699	105713699	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:105713699C>T	ENST00000258455.3	+	10	1126	c.1016C>T	c.(1015-1017)gCg>gTg	p.A339V	AC104655.2_ENST00000432211.1_RNA|AC104655.2_ENST00000449177.1_RNA	NM_182640.2	NP_872578.1	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9	339					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18						GGGAGGTCAGCGCAGGCTGGA	0.562000													20	28					0	0	1	0	0
EPB41	2035	broad.mit.edu	37	1	29362427	29362427	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:29362427G>A	ENST00000343067.4	+	10	1582	c.1455G>A	c.(1453-1455)acG>acA	p.T485T	EPB41_ENST00000349460.4_Silent_p.T276T|EPB41_ENST00000347529.3_Silent_p.T450T|EPB41_ENST00000356093.2_Silent_p.T485T|EPB41_ENST00000373800.3_Silent_p.T276T|EPB41_ENST00000373798.1_Silent_p.T485T|EPB41_ENST00000398863.2_Silent_p.T485T|EPB41_ENST00000373797.1_Silent_p.T485T	NM_001166005.1	NP_001159477.1	P11171	41_HUMAN	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	485	FERM.				blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(1)	14		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		AACATCACACGTTTTTCAGGT	0.323000													18	28					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49172005	49172005	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49172005G>A	ENST00000307885.4	-	2	1594	c.900C>T	c.(898-900)aaC>aaT	p.N300N	ADCY6_ENST00000550422.1_Silent_p.N300N|ADCY6_ENST00000357869.3_Silent_p.N300N	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	300					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						TGCCAATGACGTTGGTGCAGA	0.602000													15	30					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62455951	62455951	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:62455951G>A	ENST00000371158.2	+	28	3896	c.3782G>A	c.(3781-3783)cGc>cAc	p.R1261H	INADL_ENST00000543708.1_Missense_Mutation_p.R45H|INADL_ENST00000545929.1_5'UTR|INADL_ENST00000316485.6_Missense_Mutation_p.R1261H	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1261	PDZ 7.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						GACCGATCACGCATGAGCATA	0.453000													34	58					0	0	1	0	0
MFHAS1	9258	broad.mit.edu	37	8	8747729	8747729	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:8747729G>A	ENST00000276282.6	-	1	3426	c.2840C>T	c.(2839-2841)gCa>gTa	p.A947V		NM_004225.2	NP_004216.2	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified sequence 1	947										endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		TGGTAATGATGCATGGCTAGC	0.512000													26	42					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51329883	51329883	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:51329883G>T	ENST00000326856.4	-	5	738	c.609C>A	c.(607-609)tcC>tcA	p.S203S	KLK15_ENST00000416184.1_Intron|KLK15_ENST00000598239.1_Silent_p.S204S|KLK15_ENST00000301421.2_Intron|KLK15_ENST00000596931.1_Intron	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	204	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		TGACCTCACAGGATTCTGCGC	0.577000													18	35					7.45023e-12	8.03714e-12	1	1	0
HIVEP3	59269	broad.mit.edu	37	1	42048551	42048551	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:42048551C>A	ENST00000372584.1	-	3	2932	c.1918G>T	c.(1918-1920)Ggg>Tgg	p.G640W	HIVEP3_ENST00000429157.2_Missense_Mutation_p.G640W|HIVEP3_ENST00000372583.1_Missense_Mutation_p.G640W|HIVEP3_ENST00000247584.5_Missense_Mutation_p.G640W	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	640	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TAGATCACCCCTTTTGTTTTC	0.468000													7	208					1.26484e-09	1.34508e-09	1	1	0
CDH15	1013	broad.mit.edu	37	16	89251613	89251613	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:89251613G>A	ENST00000289746.2	+	5	600	c.535G>A	c.(535-537)Gcc>Acc	p.A179T		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	179	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGCCACAGATGCCGACGACCC	0.662000													4	13					0	0	1	0	0
ZFP36L2	678	broad.mit.edu	37	2	43452136	43452136	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:43452136C>T	ENST00000282388.3	-	2	1100	c.807G>A	c.(805-807)caG>caA	p.Q269Q	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	269					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CGCCCGGGGGCTGATGGTGGC	0.736000													4	10					0	0	1	0	0
KAL1	3730	broad.mit.edu	37	X	8502379	8502379	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:8502379G>T	ENST00000262648.3	-	13	2114	c.1965C>A	c.(1963-1965)ctC>ctA	p.L655L		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	655					axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						AAGAGGGTGGGAGCTCCGGCG	0.547000													14	2					2.32078e-09	2.46314e-09	1	1	0
KCNH1	3756	broad.mit.edu	37	1	210857205	210857205	+	Silent	SNP	C	C	T	rs138875472		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:210857205C>T	ENST00000367007.4	-	11	2476	c.2307G>A	c.(2305-2307)acG>acA	p.T769T	KCNH1_ENST00000271751.4_Silent_p.T796T	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	796	Calmodulin-binding.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity	p.T796T(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AGGATACGGGCGTGGCAGGAC	0.667000													18	26					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46332278	46332278	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46332278G>A	ENST00000245934.7	-	14	2179	c.1935C>T	c.(1933-1935)tgC>tgT	p.C645C		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	645					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GGCGGATGAGGCAGTCCTCAT	0.652000													20	34					0	0	1	0	0
HEATR4	399671	broad.mit.edu	37	14	73989701	73989701	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:73989701G>A	ENST00000553558.1	-	3	477	c.156C>T	c.(154-156)agC>agT	p.S52S	HEATR4_ENST00000560393.1_Silent_p.S5S|RP3-414A15.2_ENST00000555972.2_RNA|HEATR4_ENST00000334988.2_Silent_p.S52S	NM_001220484.1	NP_001207413.1			HEAT repeat containing 4											breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		GGTACTGTGAGCTGAAGAAGA	0.522000													11	61					0	0	1	0	0
ZNF660	285349	broad.mit.edu	37	3	44636460	44636460	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:44636460C>T	ENST00000322734.2	+	3	1108	c.775C>T	c.(775-777)Cga>Tga	p.R259*	RP11-944L7.4_ENST00000457331.1_RNA	NM_173658.2	NP_775929.2	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		TACTTCTAATCGAAACCTTGT	0.373000													31	46					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16932470	16932470	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:16932470G>A	ENST00000377833.4	-	55	8720	c.8655C>T	c.(8653-8655)aaC>aaT	p.N2885N		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2885	CUB 21.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCGGAGCCACGTTCCCACAGC	0.562000													20	25					0	0	1	0	0
EWSR1	2130	broad.mit.edu	37	22	29693897	29693897	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:29693897C>T	ENST00000397938.2	+	13	1694	c.1375C>T	c.(1375-1377)Cca>Tca	p.P459S	EWSR1_ENST00000331029.7_Missense_Mutation_p.P421S|EWSR1_ENST00000414183.2_Missense_Mutation_p.P464S|EWSR1_ENST00000332035.6_Missense_Mutation_p.P403S|EWSR1_ENST00000406548.1_Missense_Mutation_p.P458S|EWSR1_ENST00000332050.6_Missense_Mutation_p.P386S	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	459	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GGGTGGTCTGCCACCCCGTGA	0.493000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								22	39					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77450876	77450876	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:77450876C>T	ENST00000560626.2	-	5	3775	c.3300G>A	c.(3298-3300)ccG>ccA	p.P1100P	PEAK1_ENST00000312493.4_Silent_p.P1100P			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1100					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										TACAAGGGTTCGGGTCCATAG	0.423000													28	32					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62370296	62370296	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62370296C>T	ENST00000394773.2	-	21	2729	c.2422G>A	c.(2422-2424)Gtg>Atg	p.V808M	EML3_ENST00000529309.1_Intron|EML3_ENST00000531557.1_Missense_Mutation_p.V591M|EML3_ENST00000494176.2_Intron|EML3_ENST00000278845.4_Missense_Mutation_p.V809M	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	808						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						ACCGCCACCACGCGCTCGTTG	0.692000													3	10					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149460389	149460389	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149460389C>T	ENST00000286301.3	-	3	539	c.248G>A	c.(247-249)cGc>cAc	p.R83H	CSF1R_ENST00000543093.1_Missense_Mutation_p.R83H	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	83	Ig-like C2-type 1.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CTCAGTGCAGCGATAGGTCCC	0.617000													7	7					0	0	1	0	0
COIL	8161	broad.mit.edu	37	17	55027366	55027366	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:55027366G>A	ENST00000240316.4	-	2	1271	c.1237C>T	c.(1237-1239)Cgg>Tgg	p.R413W		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	413	2 X 4 AA repeats of S-L-P-A.|4 X 2 AA tandem repeats of R-G.					Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					CCTCTCCCCCGCATGCCCCGT	0.498000													17	17					0	0	1	0	0
PTTG1	9232	broad.mit.edu	37	5	159849845	159849845	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:159849845C>A	ENST00000393964.1	+	2	624	c.221C>A	c.(220-222)tCt>tAt	p.S74Y	PTTG1_ENST00000519287.1_3'UTR|PTTG1_ENST00000352433.5_Missense_Mutation_p.S74Y|PTTG1_ENST00000520452.1_Missense_Mutation_p.S74Y			O95997	PTTG1_HUMAN	pituitary tumor-transforming 1	74					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|chromosome organization|chromosome segregation|DNA repair|mitosis|spermatogenesis|transcription from RNA polymerase II promoter	cytosol|nucleus	cysteine-type endopeptidase inhibitor activity|sequence-specific DNA binding transcription factor activity|SH3 domain binding			breast(1)|large_intestine(1)|lung(4)	6	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.00219)|Epithelial(171;0.00348)|all cancers(165;0.0104)		ACAGAAAAGTCTGTAAAGACC	0.428000													47	59					4.0181e-32	4.50694e-32	1	1	0
CATSPER4	378807	broad.mit.edu	37	1	26524256	26524256	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26524256C>A	ENST00000456354.2	+	4	606	c.539C>A	c.(538-540)tCc>tAc	p.S180Y		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	180					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		AATATTCCCTCCATCAACTAC	0.512000													19	29					2.39187e-15	2.6178e-15	1	1	0
ERN2	10595	broad.mit.edu	37	16	23702664	23702664	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:23702664C>A	ENST00000256797.4	-	20	2771	c.2603G>T	c.(2602-2604)cGg>cTg	p.R868L	ERN2_ENST00000457008.2_Missense_Mutation_p.R768L	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	820	KEN.				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CCAGTTGTCCCGGACCACTGC	0.682000													15	9					3.45872e-05	3.56558e-05	1	1	0
ZNF883	169834	broad.mit.edu	37	9	115760169	115760169	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:115760169G>A	ENST00000427548.1	-	0	1644							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										ACAAGGATAGGGTTTTTCTCC	0.373000													12	17					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66191876	66191876	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66191876C>A	ENST00000311034.2	+	7	1691	c.1515C>A	c.(1513-1515)acC>acA	p.T505T		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	505					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CTCCCTGCACCTCCACCTTCC	0.587000													71	108					2.23852e-25	2.49964e-25	1	1	0
P2RY4	5030	broad.mit.edu	37	X	69478929	69478929	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:69478929G>A	ENST00000374519.2	-	1	725	c.546C>T	c.(544-546)acC>acT	p.T182T		NM_002565.3	NP_002556.1	P51582	P2RY4_HUMAN	pyrimidinergic receptor P2Y, G-protein coupled, 4	182					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			cervix(2)|endometrium(2)|large_intestine(8)|lung(6)	18						GGCACAGGACGGTGGTCCCTT	0.602000													13	4					0	0	1	0	0
IL17RD	54756	broad.mit.edu	37	3	57132270	57132270	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:57132270G>A	ENST00000296318.7	-	12	1549	c.1461C>T	c.(1459-1461)gaC>gaT	p.D487D	IL17RD_ENST00000320057.5_Silent_p.D343D|IL17RD_ENST00000463523.1_Silent_p.D343D|IL17RD_ENST00000427856.2_Silent_p.D463D	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	487	SEFIR.					Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		TACCGGGGACGTCTCCCTCGC	0.567000													11	13					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54965781	54965781	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54965781C>T	ENST00000326764.5	+	6	1078	c.599C>T	c.(598-600)aCg>aTg	p.T200M	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	163							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GGGCCCGCCACGGGCCAGGCC	0.642000													5	10					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40899994	40899994	+	Missense_Mutation	SNP	C	C	T	rs142436702	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:40899994C>T	ENST00000324001.7	-	7	4535	c.4265G>A	c.(4264-4266)cGg>cAg	p.R1422Q	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	1422					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACTCCCACTCCGGGCCTTGGG	0.687000													6	45					0	0	1	0	0
HNRNPH3	3189	broad.mit.edu	37	10	70101422	70101422	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:70101422G>A	ENST00000265866.7	+	8	1021	c.856G>A	c.(856-858)Gga>Aga	p.G286R	HNRNPH3_ENST00000354695.5_Missense_Mutation_p.G271R|HNRNPH3_ENST00000441000.2_Missense_Mutation_p.G178R|HNRNPH3_ENST00000469172.1_3'UTR	NM_012207.2|NM_021644.3	NP_036339.1|NP_067676.2	P31942	HNRH3_HUMAN	heterogeneous nuclear ribonucleoprotein H3 (2H9)	286	Gly-rich.				nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)|ovary(2)|prostate(2)	11						GGGAGGCTACGGAAGAGATGG	0.363000													29	35					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50097976	50097976	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50097976G>T	ENST00000418929.2	+	4	396	c.384G>T	c.(382-384)acG>acT	p.T128T		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	542	Pro-rich.						DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CAGGCCCCACGGAGCTCTTCA	0.677000													12	17					2.27111e-07	2.37911e-07	1	1	0
KANSL1	284058	broad.mit.edu	37	17	44171967	44171967	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:44171967G>A	ENST00000262419.6	-	3	1860	c.1390C>T	c.(1390-1392)Cgt>Tgt	p.R464C	KANSL1_ENST00000574590.1_Missense_Mutation_p.R464C|KANSL1_ENST00000575318.1_Missense_Mutation_p.R464C|KANSL1_ENST00000393476.3_5'UTR|KANSL1_ENST00000572904.1_Missense_Mutation_p.R464C|KANSL1_ENST00000432791.1_Missense_Mutation_p.R464C	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	464						MLL1 complex	protein binding										GTTTGCTGACGAATTCGATAT	0.438000													37	98					0	0	1	0	0
FOXD4L3	286380	broad.mit.edu	37	9	70918906	70918906	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:70918906C>T	ENST00000342833.2	+	1	1631	c.1039C>T	c.(1039-1041)Cga>Tga	p.R347*		NM_199135.4	NP_954586.4	Q6VB84	FX4L3_HUMAN	forkhead box D4-like 3	347						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				all cancers(8;0.00136)|Epithelial(8;0.0288)|GBM - Glioblastoma multiforme(74;0.0402)|OV - Ovarian serous cystadenocarcinoma(323;0.18)		AATTTGTCCCCGACCGCGTGG	0.637000													41	55					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38791409	38791409	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:38791409G>T	ENST00000359357.3	+	26	3395	c.3141G>T	c.(3139-3141)caG>caT	p.Q1047H	DNAH8_ENST00000449981.2_Missense_Mutation_p.Q1264H|DNAH8_ENST00000441566.1_Missense_Mutation_p.Q1047H					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTTTTGAACAGGAGATTGATG	0.313000													30	43					2.65835e-16	2.91848e-16	1	1	0
ARHGEF19	128272	broad.mit.edu	37	1	16534187	16534187	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16534187G>A	ENST00000270747.3	-	4	916	c.780C>T	c.(778-780)ggC>ggT	p.G260G	ARHGEF19_ENST00000421561.1_Silent_p.G260G	NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	260					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		CGGACCAATCGCCCTCTCGTG	0.632000													22	30					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1957835	1957835	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1957835C>T	ENST00000382895.3	+	17	3232	c.2801C>T	c.(2800-2802)gCg>gTg	p.A934V	WHSC1_ENST00000508803.1_Missense_Mutation_p.A934V|WHSC1_ENST00000382891.5_Missense_Mutation_p.A934V|WHSC1_ENST00000382892.2_Missense_Mutation_p.A934V|WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Missense_Mutation_p.A282V	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	934	PWWP 2.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		ACGCATCAGGCGCGAGTGTTC	0.493000			T	IGH@	MM								86	104					0	0	1	0	0
SLC7A1	6541	broad.mit.edu	37	13	30091325	30091325	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:30091325C>T	ENST00000380752.5	-	11	2019	c.1633G>A	c.(1633-1635)Gtc>Atc	p.V545I	SLC7A1_ENST00000473577.1_5'UTR	NM_003045.4	NP_003036.1	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	545					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|stomach(1)|urinary_tract(2)	24		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CTCCAGATGACGCCCGTGACC	0.612000													16	17					0	0	1	0	0
GRAP2	9402	broad.mit.edu	37	22	40365471	40365471	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:40365471C>T	ENST00000344138.4	+	7	1010	c.747C>T	c.(745-747)ggC>ggT	p.G249G	GRAP2_ENST00000540310.1_Silent_p.G183G|GRAP2_ENST00000407075.3_Silent_p.G249G|GRAP2_ENST00000399090.2_Silent_p.G136G|GRAP2_ENST00000544756.1_Silent_p.G177G|GRAP2_ENST00000543252.1_Silent_p.G209G	NM_004810.2	NP_004801.1	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	249					cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						CCGGCTTGGGCAGTGAAATGA	0.577000													19	27					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333321	70333321	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:70333321G>A	ENST00000338508.4	-	32	3079	c.3080C>T	c.(3079-3081)aCg>aTg	p.T1027M	SHANK2_ENST00000423696.2_Missense_Mutation_p.T647M|SHANK2_ENST00000449833.2_Missense_Mutation_p.T431M|SHANK2_ENST00000409161.1_Missense_Mutation_p.T430M			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	647					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GATGGAGCACGTCTTCTCGGG	0.652000													37	52					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121415986	121415986	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:121415986C>A	ENST00000393667.3	-	13	3494	c.3384G>T	c.(3382-3384)caG>caT	p.Q1128H	GOLGB1_ENST00000340645.5_Missense_Mutation_p.Q1123H	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1123					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TGATTAACTTCTGGATAATTG	0.418000													17	111					3.45872e-05	3.56558e-05	1	1	0
IPO9	55705	broad.mit.edu	37	1	201835898	201835898	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:201835898G>A	ENST00000361565.4	+	15	1735	c.1666G>A	c.(1666-1668)Gtg>Atg	p.V556M		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	556					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						GAGTACCCACGTGCTCCAGCC	0.453000													28	41					0	0	1	0	0
PI4K2A	55361	broad.mit.edu	37	10	99426869	99426869	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99426869C>T	ENST00000370631.3	+	8	1327	c.1270C>T	c.(1270-1272)Cgg>Tgg	p.R424W	PI4K2A_ENST00000370649.3_Missense_Mutation_p.R394W|PI4K2A_ENST00000555577.1_Missense_Mutation_p.R394W	NM_018425.2	NP_060895.1	Q9BTU6	P4K2A_HUMAN	phosphatidylinositol 4-kinase type 2 alpha	424	PI3K/PI4K.				phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(1)	12		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)		TGCTGTCATGCGGGGCCAGGT	0.498000													39	60					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	28967440	28967440	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:28967440G>A	ENST00000524189.1	-	33	4116	c.4078C>T	c.(4078-4080)Cgc>Tgc	p.R1360C		NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1360					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CTAACCTGGCGCAGACGATCT	0.512000													9	14					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17757921	17757921	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:17757921C>T	ENST00000379472.3	+	1	402	c.372C>T	c.(370-372)ggC>ggT	p.G124G	KCNC1_ENST00000265969.6_Silent_p.G124G	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	124						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GCTTCGGCGGCGCTCCTCTGG	0.706000													11	8					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1250942	1250942	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:1250942G>A	ENST00000447027.1	+	10	1192	c.1134G>A	c.(1132-1134)acG>acA	p.T378T	MUC5B_ENST00000529681.1_Silent_p.T375T|MUC5B_ENST00000531082.1_3'UTR			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	375	TIL 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ATGACATCACGCACTCTGGCT	0.692000													3	7					0	0	1	0	0
SPECC1L	23384	broad.mit.edu	37	22	24726235	24726235	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:24726235G>A	ENST00000314328.9	+	8	2517	c.2232G>A	c.(2230-2232)gcG>gcA	p.A744A	KB-1896H10.1_ENST00000358654.2_Silent_p.A744A|SPECC1L_ENST00000541492.1_Silent_p.A744A|SPECC1L_ENST00000437398.1_Silent_p.A744A	NM_001254733.1|NM_015330.3	NP_001241662.1|NP_056145.3	Q69YQ0	CYTSA_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1-like	744					cell cycle|cell division					breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(3)|stomach(2)|urinary_tract(1)	27						AAGAATCTGCGGAATGGCGGC	0.363000													49	81					0	0	1	0	0
ACADSB	36	broad.mit.edu	37	10	124813214	124813214	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:124813214C>T	ENST00000358776.4	+	11	1246	c.1232C>T	c.(1231-1233)aCg>aTg	p.T411M	ACADSB_ENST00000368869.4_Missense_Mutation_p.T309M	NM_001609.3	NP_001600.1	P45954	ACDSB_HUMAN	acyl-CoA dehydrogenase, short/branched chain	411					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	GCTTAAGGTACGATATATGAA	0.443000													21	57					0	0	1	0	0
FMNL3	91010	broad.mit.edu	37	12	50045745	50045745	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:50045745G>A	ENST00000335154.5	-	14	1807	c.1574C>T	c.(1573-1575)cCc>cTc	p.P525L	FMNL3_ENST00000550488.1_Missense_Mutation_p.P525L|FMNL3_ENST00000352151.5_Missense_Mutation_p.P474L|FMNL3_ENST00000293590.5_Missense_Mutation_p.P525L	NM_175736.4	NP_783863.4	Q8IVF7	FMNL3_HUMAN	formin-like 3	525	Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|stomach(1)	39						AGGGGGCAAGGGCGGAGCTGG	0.647000													4	13					0	0	1	0	0
ECM2	1842	broad.mit.edu	37	9	95258764	95258764	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95258764T>C	ENST00000344604.5	-	10	2082	c.1931_splice	c.e10-1	p.N645_splice	ECM2_ENST00000444490.2_Intron|CENPP_ENST00000375587.3_Intron	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	645					cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						GGAAGAATGTTCCTAAGGAAA	0.303000													18	27					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102742654	102742654	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:102742654G>A	ENST00000532855.1	-	0	475							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	ACATCCTCACGGTTCATGTCA	0.378000													4	9					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77193714	77193714	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:77193714G>A	ENST00000253506.5	+	3	1731	c.1362G>A	c.(1360-1362)tcG>tcA	p.S454S	NFATC1_ENST00000329101.4_Silent_p.S441S|NFATC1_ENST00000427363.2_Silent_p.S454S|NFATC1_ENST00000542384.1_Silent_p.S454S|NFATC1_ENST00000397790.2_5'UTR|NFATC1_ENST00000587635.1_Silent_p.S454S|NFATC1_ENST00000592223.1_Silent_p.S441S|NFATC1_ENST00000591814.1_Silent_p.S454S|NFATC1_ENST00000318065.5_Silent_p.S441S|NFATC1_ENST00000586434.1_Silent_p.S441S|NFATC1_ENST00000545796.1_5'UTR	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	454	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding	p.S441S(1)		NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		TGAAGGCGTCGGCCGGAGGAC	0.622000													6	40					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101702086	101702086	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:101702086G>A	ENST00000261637.4	+	18	2293	c.2119G>A	c.(2119-2121)Gta>Ata	p.V707I		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	707					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding	p.V707I(1)		NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						ACATGATGTGGTACAGACTGC	0.393000													21	42					0	0	1	0	0
ZNF16	7564	broad.mit.edu	37	8	146157095	146157095	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:146157095G>A	ENST00000276816.4	-	4	1264	c.1078C>T	c.(1078-1080)Cga>Tga	p.R360*	ZNF16_ENST00000394909.2_Nonsense_Mutation_p.R360*	NM_001029976.2	NP_001025147.2	P17020	ZNF16_HUMAN	zinc finger protein 16	360					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|lung(9)|ovary(5)|prostate(1)|skin(1)|urinary_tract(1)	29	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		TTTGAGCTTCGCCTGAAGGCC	0.522000													23	29					0	0	1	0	0
GMFG	9535	broad.mit.edu	37	19	39823717	39823717	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39823717C>A	ENST00000598034.1	-	4	229	c.200_splice	c.e4+1	p.R67_splice	GMFG_ENST00000594700.1_Intron|GMFG_ENST00000600322.1_Splice_Site_p.R34_splice|GMFG_ENST00000595636.1_Splice_Site_p.R67_splice|GMFG_ENST00000597595.1_Splice_Site_p.R67_splice|GMFG_ENST00000602185.1_Splice_Site_p.R18_splice|GMFG_ENST00000253054.8_Splice_Site_p.R34_splice|GMFG_ENST00000601387.1_Splice_Site_p.R26_splice			O60234	GMFG_HUMAN	glia maturation factor, gamma	67	ADF-H.				protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity			breast(1)|large_intestine(2)|liver(2)|lung(3)|skin(1)|stomach(1)	10	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.15e-27)|all cancers(26;1.3e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CCCAGGATACCTGGGCTGTCT	0.532000													21	35					1.2644e-06	1.31806e-06	1	1	0
PNPLA1	285848	broad.mit.edu	37	6	36275449	36275449	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:36275449C>T	ENST00000394571.2	+	8	1555	c.1555C>T	c.(1555-1557)Cca>Tca	p.P519S	PNPLA1_ENST00000388715.3_Missense_Mutation_p.P424S|PNPLA1_ENST00000312917.5_Missense_Mutation_p.P433S	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	519					lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						AAAAGGCTTCCCAAGACATTC	0.468000													7	17					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126367515	126367515	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126367515G>A	ENST00000394329.3	+	8	7274	c.7261G>A	c.(7261-7263)Gca>Aca	p.A2421T	FAT4_ENST00000335110.5_Missense_Mutation_p.A719T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2421	Cadherin 23.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A2421T(2)		NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CATCACCAGCGCATTGTTAGA	0.443000													34	47					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99696033	99696033	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99696033G>A	ENST00000370597.3	-	3	670	c.315C>T	c.(313-315)taC>taT	p.Y105Y	CRTAC1_ENST00000370591.2_Silent_p.Y105Y|CRTAC1_ENST00000298819.4_Silent_p.Y105Y	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	105						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CCCGCAGCGCGTAGTAGGGTG	0.622000													11	24					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81381467	81381467	+	Silent	SNP	G	G	A	rs143891160		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:81381467G>A	ENST00000222390.5	-	5	820	c.594C>T	c.(592-594)taC>taT	p.Y198Y	HGF_ENST00000453411.1_Silent_p.Y193Y|HGF_ENST00000457544.2_Silent_p.Y193Y|HGF_ENST00000444829.2_Silent_p.Y198Y|HGF_ENST00000423064.2_Silent_p.Y198Y	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	198	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						CACAGACTTCGTAGCGTACCT	0.468000													18	38					0	0	1	0	0
GNLY	10578	broad.mit.edu	37	2	85922499	85922499	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:85922499C>T	ENST00000409696.3	+	3	346	c.64C>T	c.(64-66)Cgt>Tgt	p.R22C	GNLY_ENST00000263863.4_Missense_Mutation_p.R37C|GNLY_ENST00000533041.1_3'UTR|GNLY_ENST00000524600.1_Missense_Mutation_p.R64C	NM_012483.2	NP_036615.2	P22749	GNLY_HUMAN	granulysin	37					cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(4)|kidney(10)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	19						AGCCCACCTGCGTGATGAGGA	0.622000													6	17					0	0	1	0	0
EIF4B	1975	broad.mit.edu	37	12	53412636	53412636	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53412636A>G	ENST00000262056.9	+	3	532	c.206A>G	c.(205-207)gAc>gGc	p.D69G	EIF4B_ENST00000420463.3_Missense_Mutation_p.D69G|RP11-983P16.4_ENST00000552905.1_RNA|EIF4B_ENST00000416762.3_Missense_Mutation_p.D69G|RP11-983P16.4_ENST00000549388.1_RNA|EIF4B_ENST00000551527.1_3'UTR	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	69					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						CCTCCAATTGACCGTTCCATC	0.498000													5	87					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55838292	55838292	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:55838292C>T	ENST00000302000.6	-	3	1283	c.1189G>A	c.(1189-1191)Gct>Act	p.A397T	PYGO1_ENST00000563719.1_Missense_Mutation_p.A397T	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	397					Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		TCTTTGTCAGCCATACAGGTA	0.428000													10	39					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121943235	121943235	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:121943235G>A	ENST00000442488.2	-	2	999	c.932C>T	c.(931-933)aCg>aTg	p.T311M	FEZF1_ENST00000427185.2_Missense_Mutation_p.T261M|FEZF1_ENST00000331178.4_Missense_Mutation_p.T307M	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	311					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						ACACACCTGCGTGTGAATGAT	0.463000													32	44					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132184906	132184906	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:132184906C>T	ENST00000260818.6	+	18	2208	c.1960C>T	c.(1960-1962)Cgc>Tgc	p.R654C	DNAJC13_ENST00000486798.1_3'UTR	NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	654							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						CTTGTTGAAACGCATTTTGGT	0.353000													3	33					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65942213	65942213	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:65942213G>A	ENST00000321892.4	+	23	7828	c.7767G>A	c.(7765-7767)gtG>gtA	p.V2589V	BPTF_ENST00000335221.5_Intron|BPTF_ENST00000424123.3_Intron|BPTF_ENST00000306378.6_Silent_p.V2463V			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2589					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			AAAGTGGTGTGCCCCAGCAAA	0.507000													14	16					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45188748	45188748	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:45188748G>A	ENST00000279027.4	-	13	1740	c.1722C>T	c.(1720-1722)ggC>ggT	p.G574G	SLC13A3_ENST00000396360.1_Silent_p.G492G|SLC13A3_ENST00000472148.1_Silent_p.G492G|SLC13A3_ENST00000413164.2_Silent_p.G524G|SLC13A3_ENST00000290317.5_Silent_p.G527G|SLC13A3_ENST00000435032.1_Silent_p.G159G|SLC13A3_ENST00000495082.1_Silent_p.G527G	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	574						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	CCGGGAAGGTGCCCAGCTGGA	0.562000													27	37					0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1818468	1818468	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1818468G>A	ENST00000302787.2	-	12	2213	c.1917C>T	c.(1915-1917)aaC>aaT	p.N639N		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	639					cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			TGGGCATGCCGTTGGCCGGGG	0.622000													4	33					0	0	1	0	0
C1orf172	126695	broad.mit.edu	37	1	27276630	27276630	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:27276630C>G	ENST00000320567.5	-	4	1215	c.1127G>C	c.(1126-1128)aGc>aCc	p.S376T		NM_152365.2	NP_689578.2	Q8NAX2	CA172_HUMAN	chromosome 1 open reading frame 172	376										NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		TGAGTCATGGCTTGCTGGGTA	0.607000													30	36					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587468	36587468	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36587468G>A	ENST00000332987.1	-	7	1121	c.699C>T	c.(697-699)gaC>gaT	p.D233D	APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000352371.1_Silent_p.D236D|APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000404685.3_3'UTR|APOL4_ENST00000405511.1_3'UTR			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	237					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						TTGTGGCTTCGTCAAAATCAA	0.458000													11	28					0	0	1	0	0
NXPH2	11249	broad.mit.edu	37	2	139429115	139429115	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:139429115G>T	ENST00000272641.3	-	2	278	c.172C>A	c.(172-174)Ctg>Atg	p.L58M		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	58	II.				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		TTAACAAACAGGCGCAGGGGA	0.572000													6	89					0.000157383	0.000161063	1	1	0
UPF1	5976	broad.mit.edu	37	19	18971713	18971713	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18971713C>T	ENST00000262803.5	+	17	2651	c.2379C>T	c.(2377-2379)atC>atT	p.I793I	UPF1_ENST00000599848.1_Silent_p.I804I	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	804					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						TTGGCATCATCACGCCCTACG	0.617000													6	11					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361258	107361258	+	Missense_Mutation	SNP	G	G	A	rs75243926		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:107361258G>A	ENST00000374779.2	-	1	530	c.437C>T	c.(436-438)gCt>gTt	p.A146V		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	146					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						CCAGGACCCAGCTGCCATGGG	0.473000													50	48					0	0	1	0	0
KIAA1430	57587	broad.mit.edu	37	4	186097206	186097206	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:186097206C>T	ENST00000458385.2	-	3	1174		c.e3-1		KIAA1430_ENST00000296775.6_Splice_Site|KIAA1430_ENST00000514798.1_Splice_Site|KIAA1430_ENST00000502992.1_Splice_Site	NM_020827.1	NP_065878.1	Q9P2B7	K1430_HUMAN	KIAA1430											endometrium(3)|kidney(2)|large_intestine(5)|upper_aerodigestive_tract(1)	11		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		TGCAGAAAAGCTACAGAAAAG	0.348000													9	8					0	0	1	0	0
TMEM147	10430	broad.mit.edu	37	19	36038288	36038288	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36038288C>T	ENST00000392204.2	+	6	795	c.467C>T	c.(466-468)aCg>aTg	p.T156M	TMEM147_ENST00000392205.1_3'UTR|TMEM147_ENST00000222284.5_Missense_Mutation_p.T205M	NM_001242597.1	NP_001229526.1	Q9BVK8	TM147_HUMAN	transmembrane protein 147	205						endoplasmic reticulum membrane|integral to membrane	protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	6	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCAGTGGTAACGGGGCTGCTG	0.557000													13	16					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175716874	175716874	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:175716874G>A	ENST00000443967.1	+	4	697	c.290G>A	c.(289-291)aGc>aAc	p.S97N	SIMC1_ENST00000429602.2_Missense_Mutation_p.S116N|SIMC1_ENST00000430704.2_Intron|SIMC1_ENST00000341199.6_Intron|SIMC1_ENST00000503595.1_3'UTR					SUMO-interacting motifs containing 1																		GTGGACAGAAGCTCTCAGCCT	0.517000													33	41					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44575991	44575991	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44575991G>A	ENST00000289547.4	-	4	1773	c.1718C>T	c.(1717-1719)aCg>aTg	p.T573M	NPC1L1_ENST00000381160.3_Missense_Mutation_p.T573M|NPC1L1_ENST00000423141.1_Missense_Mutation_p.T573M|NPC1L1_ENST00000546276.1_Missense_Mutation_p.T573M	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	573					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GAGGGAGAACGTCATGATCAG	0.602000													16	28					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7984217	7984217	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7984217T>C	ENST00000319144.4	-	4	772	c.512A>G	c.(511-513)aAc>aGc	p.N171S	AC129492.6_ENST00000399413.3_3'UTR	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	171	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						CCGGTTGGGGTTGCGATGCCT	0.652000										Multiple Myeloma(8;0.094)			22	34					0	0	1	0	0
G6PC3	92579	broad.mit.edu	37	17	42151578	42151578	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42151578A>G	ENST00000269097.4	+	2	500	c.269A>G	c.(268-270)tAc>tGc	p.Y90C		NM_138387.3	NP_612396.1	Q9BUM1	G6PC3_HUMAN	glucose 6 phosphatase, catalytic, 3	90					gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			endometrium(2)|large_intestine(5)|lung(1)|ovary(2)|skin(1)	11		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TCTGGTTACTACAGCCAGGCT	0.522000													4	175					0	0	1	0	0
LRRC61	65999	broad.mit.edu	37	7	150034640	150034640	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150034640C>A	ENST00000359623.4	+	3	1278	c.690C>A	c.(688-690)tgC>tgA	p.C230*	LRRC61_ENST00000323078.7_Nonsense_Mutation_p.C230*|LRRC61_ENST00000493307.1_Nonsense_Mutation_p.C230*	NM_001142928.1	NP_001136400.1	Q9BV99	LRC61_HUMAN	leucine rich repeat containing 61	230										endometrium(2)|large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(82;0.011)			TGCAGGAGTGCTGGGACCTGG	0.677000													10	13					0.00621372	0.00628055	1	1	0
MIB2	142678	broad.mit.edu	37	1	1563681	1563681	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1563681C>T	ENST00000357210.4	+	15	2260	c.2044C>T	c.(2044-2046)Cgg>Tgg	p.R682W	MIB2_ENST00000504599.1_Missense_Mutation_p.R638W|MIB2_ENST00000378712.1_Missense_Mutation_p.R559W|MIB2_ENST00000520777.1_Missense_Mutation_p.R735W|MIB2_ENST00000360522.4_Missense_Mutation_p.R647W|MIB2_ENST00000378708.1_Missense_Mutation_p.R588W|MIB2_ENST00000505820.2_Missense_Mutation_p.R739W|MIB2_ENST00000378710.3_Missense_Mutation_p.R646W|MIB2_ENST00000518681.1_Missense_Mutation_p.R674W|MIB2_ENST00000355826.5_Missense_Mutation_p.R725W	NM_080875.2	NP_543151.2	Q96AX9	MIB2_HUMAN	mindbomb E3 ubiquitin protein ligase 2	682					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|lung(7)|prostate(4)|upper_aerodigestive_tract(1)	18	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGCTCGGGCGCGGCAGCTGGT	0.657000													6	21					0	0	1	0	0
RPL36AL	6166	broad.mit.edu	37	14	50085776	50085776	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:50085776C>T	ENST00000298289.6	-	2	206	c.47G>A	c.(46-48)gGc>gAc	p.G16D		NM_001001.4	NP_000992.1	Q969Q0	RL36L_HUMAN	ribosomal protein L36a-like	16					translation	ribosome	structural constituent of ribosome					all_epithelial(31;0.0021)|Breast(41;0.0124)					CTGATGCTTGCCACACTTCTT	0.438000													27	49					0	0	1	0	0
KIAA1432	57589	broad.mit.edu	37	9	5769250	5769250	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:5769250C>T	ENST00000414202.2	+	22	3609	c.3418C>T	c.(3418-3420)Cga>Tga	p.R1140*	KIAA1432_ENST00000418622.3_Nonsense_Mutation_p.R1061*|KIAA1432_ENST00000251879.6_Nonsense_Mutation_p.R1140*|KIAA1432_ENST00000381532.2_Nonsense_Mutation_p.R1061*|KIAA1432_ENST00000449720.2_Nonsense_Mutation_p.R1024*	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	1140						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TGGAAAATACCGAACTGGTAA	0.368000													59	82					0	0	1	0	0
ALDOC	230	broad.mit.edu	37	17	26901208	26901208	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26901208C>T	ENST00000226253.4	-	7	1151	c.676G>A	c.(676-678)Ggg>Agg	p.G226R	ALDOC_ENST00000395321.2_Missense_Mutation_p.G226R|RP11-192H23.5_ENST00000585189.1_RNA|ALDOC_ENST00000395319.3_Missense_Mutation_p.G198R	NM_005165.2	NP_005156.1	P09972	ALDOC_HUMAN	aldolase C, fructose-bisphosphate	226					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11	Lung NSC(42;0.00431)					AGCAGGGTCCCCTCCAGGTAT	0.587000													36	64					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52522464	52522464	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52522464G>A	ENST00000345716.4	+	16	3090	c.2956G>A	c.(2956-2958)Gtg>Atg	p.V986M	NISCH_ENST00000479054.1_Missense_Mutation_p.V986M	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	986					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		TGCCATCTTCGTGCTGCCCCA	0.642000													13	51					0	0	1	0	0
RAP1B	5908	broad.mit.edu	37	12	69044218	69044218	+	Silent	SNP	C	C	T	rs144054951		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:69044218C>T	ENST00000250559.9	+	3	327	c.96C>T	c.(94-96)taC>taT	p.Y32Y	RAP1B_ENST00000543697.1_Silent_p.Y32Y|RAP1B_ENST00000541216.1_Silent_p.Y32Y|RAP1B_ENST00000543393.1_Intron|RAP1B_ENST00000539091.1_Intron|RAP1B_ENST00000450214.2_Intron|RAP1B_ENST00000393436.5_Silent_p.Y32Y|RAP1B_ENST00000537460.1_Silent_p.Y32Y|RAP1B_ENST00000378985.3_Intron|RAP1B_ENST00000463493.1_Intron|RAP1B_ENST00000542145.1_Silent_p.Y32Y|RAP1B_ENST00000540209.1_Silent_p.Y32Y|RAP1B_ENST00000341355.5_Silent_p.Y32Y	NM_001010942.2|NM_001251921.1|NM_001251922.1|NM_015646.5	NP_001010942.1|NP_001238850.1|NP_001238851.1|NP_056461.1	P61224	RAP1B_HUMAN	RAP1B, member of RAS oncogene family	32					blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(2)|urinary_tract(2)	12	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		TAGAAAAATACGATCCTACGA	0.239000													18	31					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44019259	44019259	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:44019259G>A	ENST00000359947.4	+	4	528	c.188G>A	c.(187-189)cGc>cAc	p.R63H	PTPRF_ENST00000372414.3_Missense_Mutation_p.R63H|PTPRF_ENST00000438120.1_Missense_Mutation_p.R63H|PTPRF_ENST00000372413.3_Missense_Mutation_p.R63H	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	63	Ig-like C2-type 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity	p.R53H(1)		NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCCAAGCCGCGCATCACATGG	0.597000													43	85					0	0	1	0	0
SPIN1	10927	broad.mit.edu	37	9	91063856	91063856	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:91063856G>A	ENST00000375859.3	+	3	331	c.52_splice	c.e3-1	p.G18_splice	SPIN1_ENST00000469017.2_3'UTR|SPIN1_ENST00000541629.1_Splice_Site_p.G18_splice	NM_006717.2	NP_006708.2	Q9Y657	SPIN1_HUMAN	spindlin 1	18					cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding			endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4						TCTCTTACAGGCCATGCTGGA	0.378000													24	32					0	0	1	0	0
MCM8	84515	broad.mit.edu	37	20	5967973	5967973	+	Missense_Mutation	SNP	G	G	A	rs146056799	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:5967973G>A	ENST00000378896.3	+	17	2586	c.2209G>A	c.(2209-2211)Gct>Act	p.A737T	MCM8_ENST00000378886.2_Missense_Mutation_p.A777T|MCM8_ENST00000378883.1_Missense_Mutation_p.A690T|MCM8_ENST00000265187.4_Missense_Mutation_p.A721T	NM_032485.4|NM_182802.1	NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	737					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						CAAAGAAGACGCTGAGGATAT	0.318000													22	23					0	0	1	0	0
AURKC	6795	broad.mit.edu	37	19	57746297	57746297	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:57746297G>A	ENST00000302804.7	+	6	816	c.630G>A	c.(628-630)atG>atA	p.M210I	AURKC_ENST00000599062.1_Missense_Mutation_p.M207I|AURKC_ENST00000415300.2_Missense_Mutation_p.M191I|AURKC_ENST00000448930.1_Missense_Mutation_p.M176I|AURKC_ENST00000598785.1_Missense_Mutation_p.M176I	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	210	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity	p.M176I(1)		breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		CGCCAGAAATGATTGAGGGGA	0.507000													6	19					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50902042	50902042	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:50902042G>A	ENST00000313478.7	-	18	2678	c.2397C>T	c.(2395-2397)agC>agT	p.S799S	TRPM7_ENST00000560955.1_Silent_p.S799S	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	799					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		AGTTGTTTTCGCTGTCATCCA	0.353000													23	47					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114177072	114177072	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:114177072C>T	ENST00000357077.4	+	11	1225	c.1172C>T	c.(1171-1173)cCg>cTg	p.P391L	ANK2_ENST00000264366.6_Missense_Mutation_p.P391L|ANK2_ENST00000394537.3_Missense_Mutation_p.P391L|ANK2_ENST00000506722.1_Missense_Mutation_p.P370L	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	391					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGAGCCAATCCGAACGCCAGA	0.493000													19	45					0	0	1	0	0
ORM2	5005	broad.mit.edu	37	9	117092738	117092738	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:117092738G>A	ENST00000412657.1	+	1	587	c.554G>A	c.(553-555)cGc>cAc	p.R185H	ORM2_ENST00000431067.2_Missense_Mutation_p.A47T					orosomucoid 2											breast(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(1)	7		Myeloproliferative disorder(63;0.163)				GTTTTATATCGCATCGGCCTT	0.502000													11	46					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9543668	9543668	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:9543668C>T	ENST00000378429.3	-	7	2032	c.1486G>A	c.(1486-1488)Gtg>Atg	p.V496M	PAK7_ENST00000353224.5_Missense_Mutation_p.V496M|PAK7_ENST00000378423.1_Missense_Mutation_p.V496M	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	496	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			CGCATGATCACGACCTGGGGA	0.453000													33	102					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55168415	55168415	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55168415C>T	ENST00000414150.2	+	21	3839	c.3561C>T	c.(3559-3561)tgC>tgT	p.C1187C	MROH7_ENST00000454855.2_Silent_p.C705C|MROH7_ENST00000409996.1_Silent_p.C755C|MROH7_ENST00000421030.2_Silent_p.C1187C					maestro heat-like repeat family member 7																		TTTGCAAGTGCCTTGTGAGTG	0.493000													21	31					0	0	1	0	0
MAB21L1	4081	broad.mit.edu	37	13	36049744	36049744	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:36049744C>T	ENST00000379919.4	-	1	1088	c.532G>A	c.(532-534)Ggg>Agg	p.G178R	NBEA_ENST00000310336.4_Intron|NBEA_ENST00000379939.2_Intron|NBEA_ENST00000400445.3_Intron|NBEA_ENST00000540320.1_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	178					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		GGCCAGATCCCGGTGCATTTA	0.592000													11	48					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70903983	70903983	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:70903983G>A	ENST00000264436.3	-	13	1982	c.1538C>T	c.(1537-1539)gCg>gTg	p.A513V	ADD2_ENST00000407644.2_Missense_Mutation_p.A513V|ADD2_ENST00000430656.1_Missense_Mutation_p.A529V|ADD2_ENST00000413157.2_Missense_Mutation_p.A513V|ADD2_ENST00000355733.3_Missense_Mutation_p.A513V	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	513					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CTGAGGCCCCGCTGACTTCAC	0.602000													20	35					0	0	1	0	0
RPL28	6158	broad.mit.edu	37	19	55899546	55899546	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55899546C>T	ENST00000560583.1	+	4	494	c.454C>T	c.(454-456)Cat>Tat	p.H152Y	RPL28_ENST00000560055.1_Intron|RPL28_ENST00000344063.2_Intron|RPL28_ENST00000458349.2_Intron|RPL28_ENST00000558815.1_Intron|RPL28_ENST00000559463.1_Intron|RPL28_ENST00000558131.1_Intron	NM_001136134.1	NP_001129606.1	P46779	RL28_HUMAN	ribosomal protein L28	0					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(2)|lung(1)	6	Breast(117;0.191)	Renal(1328;0.245)	LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		CCACACCCAGCATTGGCCTAG	0.647000													5	3					0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231339665	231339665	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:231339665C>T	ENST00000444294.3	+	6	2439	c.1581C>T	c.(1579-1581)agC>agT	p.S527S	TRIM67_ENST00000449018.3_Silent_p.S467S|TRIM67_ENST00000366653.5_Silent_p.S529S|TRIM67_ENST00000366652.2_Silent_p.S529S	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	529	Fibronectin type-III.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GTAACAACAGCGTCACGCTGG	0.662000													14	15					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56481858	56481858	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:56481858G>C	ENST00000370765.6	-	24	6514	c.6407C>G	c.(6406-6408)gCc>gGc	p.A2136G	DST_ENST00000370769.4_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000446842.2_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1527					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AATTGAGGTGGCTTTCGTCAG	0.423000													23	40					0	0	1	0	0
DCXR	51181	broad.mit.edu	37	17	79993888	79993888	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79993888C>T	ENST00000306869.2	-	8	732	c.683G>A	c.(682-684)gGc>gAc	p.G228D		NM_001195218.1|NM_016286.3	NP_001182147.1|NP_057370.1	Q7Z4W1	DCXR_HUMAN	dicarbonyl/L-xylulose reductase	228					D-xylose metabolic process|glucose metabolic process|protein homotetramerization|xylulose metabolic process	membrane	binding|L-xylulose reductase (NADP+) activity	p.G228D(1)		kidney(1)|lung(3)	4	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CGTGGTCATGCCACTTCGGTC	0.642000													36	41					0	0	1	0	0
HSPD1	3329	broad.mit.edu	37	2	198353833	198353833	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:198353833G>A	ENST00000388968.3	-	9	1375	c.1108C>T	c.(1108-1110)Cgt>Tgt	p.R370C	HSPD1_ENST00000345042.2_Missense_Mutation_p.R370C	NM_002156.4	NP_002147.2	P10809	CH60_HUMAN	heat shock 60kDa protein 1 (chaperonin)	370					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding	p.R370S(1)		NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(7)|skin(1)	17			Epithelial(96;0.225)			TCTTGAATACGTTTTTCAATT	0.398000													34	39					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47278811	47278811	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47278811C>T	ENST00000542575.2	-	8	2210	c.1582G>A	c.(1582-1584)Gca>Aca	p.A528T	SLC1A5_ENST00000434726.2_Missense_Mutation_p.A326T|SLC1A5_ENST00000412532.2_Missense_Mutation_p.A300T|SLC1A5_ENST00000594991.1_Missense_Mutation_p.A352T|FKRP_ENST00000600646.1_Intron	NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	528					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	GCATCCCCTGCGGGCCCCCGA	0.592000													40	66					0	0	1	0	0
ARG1	383	broad.mit.edu	37	6	131904532	131904532	+	Missense_Mutation	SNP	G	G	A	rs104893948		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:131904532G>A	ENST00000368087.3	+	7	842	c.703G>A	c.(703-705)Gga>Aga	p.G235R	ARG1_ENST00000476845.1_Intron|ARG1_ENST00000356962.2_Missense_Mutation_p.G243R|MED23_ENST00000354577.4_Intron			P05089	ARGI1_HUMAN	arginase 1	235			G -> R (in ARGIN).		arginine catabolic process|urea cycle	cytosol	arginase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|skin(3)	14	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0106)|OV - Ovarian serous cystadenocarcinoma(155;0.0713)	L-Ornithine(DB00129)	TGATGTTGACGGACTGGACCC	0.408000													49	79					0	0	1	0	0
RP11-1094M14.11	0	broad.mit.edu	37	17	33900674	33900674	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:33900674C>T	ENST00000592381.1	+	0	382																											TGAAATGCAGCGATGCGATGA	0.423000													18	39					0	0	1	0	0
PCDHA4	0	broad.mit.edu	37	5	140188964	140188964	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140188964C>T	ENST00000530339.1	+	1	2192	c.2192C>T	c.(2191-2193)gCg>gTg	p.A731V	PCDHA4_ENST00000512229.2_Missense_Mutation_p.A731V|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.A731V|PCDHA2_ENST00000526136.1_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGAGGGCGCGTGCGCTCCG	0.667000													19	30					0	0	1	0	0
MFSD12	126321	broad.mit.edu	37	19	3542791	3542791	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3542791C>A	ENST00000398558.4	-	10	1604	c.1605G>T	c.(1603-1605)tgG>tgT	p.W535C	C19orf71_ENST00000329493.5_Intron|MFSD12_ENST00000389395.3_Intron	NM_021731.2	NP_068377.2	Q6NUT3	CS028_HUMAN	major facilitator superfamily domain containing 12	0					transmembrane transport	integral to membrane				cervix(1)|endometrium(2)|lung(4)|urinary_tract(2)	9						AGTGGGTCCCCCAGTCTTCCC	0.622000													12	5					0.0167234	0.0168567	1	1	0
TNK2	10188	broad.mit.edu	37	3	195611759	195611759	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195611759C>T	ENST00000333602.6	-	4	997	c.380G>A	c.(379-381)cGc>cAc	p.R127H	TNK2_ENST00000468819.1_5'UTR|TNK2_ENST00000316664.3_Missense_Mutation_p.R127H|TNK2_ENST00000381916.2_Missense_Mutation_p.R190H|TNK2_ENST00000428187.1_Missense_Mutation_p.R159H|TNK2_ENST00000392400.1_Missense_Mutation_p.R127H	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	127	Protein kinase.				positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CTCCAGGAGGCGCAGGTCCTT	0.682000													5	14					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18681926	18681926	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:18681926C>T	ENST00000380548.4	+	12	1797	c.1458C>T	c.(1456-1458)tgC>tgT	p.C486C	ADAMTSL1_ENST00000327883.7_Silent_p.C486C|ADAMTSL1_ENST00000276935.6_Silent_p.C486C	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	486	TSP type-1 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		AAGAGGAATGCATCGTACCCA	0.488000													38	66					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64120867	64120867	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64120867G>T	ENST00000356786.5	+	22	3776	c.3732G>T	c.(3730-3732)caG>caT	p.Q1244H	CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000359902.2_Missense_Mutation_p.Q396H|CCDC88B_ENST00000301897.4_5'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	1244					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AGAACCGGCAGCTGCTGGCTG	0.662000													7	15					0.0293803	0.0295506	1	1	0
NTSR1	4923	broad.mit.edu	37	20	61389666	61389666	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:61389666G>A	ENST00000370501.3	+	3	1336	c.965G>A	c.(964-966)cGg>cAg	p.R322Q	NTSR1_ENST00000482259.1_3'UTR	NM_002531.2	NP_002522.2	P30989	NTR1_HUMAN	neurotensin receptor 1 (high affinity)	322						endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(16)|prostate(1)|skin(3)	27	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			TACCACGTGCGGCGCCTCATG	0.587000													21	25					0	0	1	0	0
PIK3R4	30849	broad.mit.edu	37	3	130424583	130424583	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:130424583T>G	ENST00000356763.3	-	12	3311	c.2754A>C	c.(2752-2754)aaA>aaC	p.K918N		NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	918					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						GTATTACTGGTTTTTTATTTT	0.343000													28	22					0	0	1	0	0
B3GALT5	10317	broad.mit.edu	37	21	41033253	41033253	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:41033253G>T	ENST00000380620.3	+	5	1359	c.767G>T	c.(766-768)aGa>aTa	p.R256I	B3GALT5_ENST00000398714.2_Missense_Mutation_p.R256I|B3GALT5_ENST00000380618.1_Missense_Mutation_p.R256I|AF064860.5_ENST00000416555.1_RNA|B3GALT5_ENST00000343118.4_Missense_Mutation_p.R256I			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	256					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				CTGAACATCAGATTGGAGGAG	0.552000													27	39					4.22769e-11	4.54161e-11	1	1	0
SCN4A	6329	broad.mit.edu	37	17	62049810	62049810	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62049810C>A	ENST00000435607.1	-	2	370	c.294G>T	c.(292-294)aaG>aaT	p.K98N	SCN4A_ENST00000578147.1_Missense_Mutation_p.K98N	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	98					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TGGCCTTGCCCTTGTTGAGTA	0.577000													4	17					0.00116845	0.0011864	1	1	0
C7orf31	136895	broad.mit.edu	37	7	25175697	25175697	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:25175697C>T	ENST00000409280.1	-	10	1975	c.1667G>A	c.(1666-1668)cGt>cAt	p.R556H	C7orf31_ENST00000283905.3_Missense_Mutation_p.R556H			Q8N865	CG031_HUMAN	chromosome 7 open reading frame 31	556								p.R556H(1)		autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	14						TTTATGGAAACGCTTTTGTGC	0.413000													9	90					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49445673	49445673	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49445673C>T	ENST00000301067.7	-	10	1792	c.1793G>A	c.(1792-1794)cGt>cAt	p.R598H		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TGGGAACAGACGAGATGCCTC	0.612000													19	24					0	0	1	0	0
TOX3	27324	broad.mit.edu	37	16	52498096	52498096	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:52498096G>A	ENST00000219746.9	-	3	442	c.158C>T	c.(157-159)aCa>aTa	p.T53I	TOX3_ENST00000407228.3_Splice_Site_p.T48_splice	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	53					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						TGTGTGGAATGTCTGCTAAAA	0.463000													19	78					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7415883	7415883	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7415883C>T	ENST00000322644.6	+	27	4979	c.4580C>T	c.(4579-4581)gCc>gTc	p.A1527V		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1527					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				GCAACCCCTGCCTATGGCGCC	0.582000													12	22					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159176048	159176048	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:159176048G>A	ENST00000537147.1	+	3	1662	c.819G>A	c.(817-819)ttG>ttA	p.L273L	DARC_ENST00000368122.2_Silent_p.L273L|DARC_ENST00000368121.2_Silent_p.L275L			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	273					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					TGTTGCTGTTGTCAACATGTC	0.567000													5	135					0	0	1	0	0
PTRH2	51651	broad.mit.edu	37	17	57774844	57774844	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:57774844C>T	ENST00000470557.2	-	1	3942	c.496G>A	c.(496-498)Gca>Aca	p.A166T	PTRH2_ENST00000409433.2_Missense_Mutation_p.A167T|PTRH2_ENST00000537860.1_Missense_Mutation_p.A166T|PTRH2_ENST00000393038.2_Missense_Mutation_p.A166T			Q9Y3E5	PTH2_HUMAN	peptidyl-tRNA hydrolase 2	166					apoptosis|translation	mitochondrion	aminoacyl-tRNA hydrolase activity			large_intestine(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					ATTAGGTCTGCTGGTCCTGGC	0.453000													13	38					0	0	1	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1857628	1857628	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:1857628C>T	ENST00000518288.1	+	19	2370	c.2207C>T	c.(2206-2208)gCg>gTg	p.A736V	ARHGEF10_ENST00000349830.3_Missense_Mutation_p.A712V|ARHGEF10_ENST00000398564.1_Missense_Mutation_p.A737V|ARHGEF10_ENST00000520359.1_Missense_Mutation_p.A674V|ARHGEF10_ENST00000262112.6_Missense_Mutation_p.A737V			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	737					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		GTTGCTAACGCGAAACCAAGT	0.612000													11	16					0	0	1	0	0
TNK1	8711	broad.mit.edu	37	17	7287852	7287852	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7287852G>A	ENST00000570896.1	+	8	1362	c.916G>A	c.(916-918)Gtg>Atg	p.V306M	TNK1_ENST00000311668.2_Missense_Mutation_p.V306M|TNK1_ENST00000576812.1_Missense_Mutation_p.V306M			Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	306	Protein kinase.				protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(2)|pancreas(1)	16		Prostate(122;0.157)				TGCCTCGGACGTGTGGATGTT	0.667000													8	9					0	0	1	0	0
CHRNB2	1141	broad.mit.edu	37	1	154544124	154544124	+	Silent	SNP	G	G	A	rs140739605		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154544124G>A	ENST00000368476.3	+	5	1089	c.825G>A	c.(823-825)gcG>gcA	p.A275A		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	275					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	TGCTGCTGGCGCTCACGGTCT	0.577000													35	44					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174772	51174772	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:51174772C>T	ENST00000440970.1	-	2	1501	c.1070G>A	c.(1069-1071)tGc>tAc	p.C357Y	SALL1_ENST00000251020.4_Missense_Mutation_p.C454Y|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	454					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GACCTTCGCGCAGAACCTGCA	0.517000													17	70					0	0	1	0	0
KCNJ14	3770	broad.mit.edu	37	19	48965166	48965166	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:48965166G>A	ENST00000391884.1	+	1	661	c.185G>A	c.(184-186)cGt>cAt	p.R62H	KCNJ14_ENST00000342291.2_Missense_Mutation_p.R62H			Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 14	62						voltage-gated potassium channel complex	inward rectifier potassium channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|skin(2)|urinary_tract(1)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		TGCAACGTGCGTTTCGTAAAC	0.687000													4	7					0	0	1	0	0
ARV1	64801	broad.mit.edu	37	1	231132996	231132996	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:231132996C>T	ENST00000310256.2	+	5	860	c.803C>T	c.(802-804)tCt>tTt	p.S268F	ARV1_ENST00000366658.2_Missense_Mutation_p.S228F	NM_022786.1	NP_073623.1	Q9H2C2	ARV1_HUMAN	ARV1 homolog (S. cerevisiae)	268					sphingolipid metabolic process	integral to membrane				breast(3)|large_intestine(2)|lung(2)	7	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		ATCTTTAAATCTCAGGACTTC	0.423000													27	41					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90484448	90484448	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:90484448T>C	ENST00000369393.3	-	13	1941	c.1826A>G	c.(1825-1827)gAa>gGa	p.E609G	MDN1_ENST00000428876.1_Missense_Mutation_p.E609G			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	609					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACAAAAGAATTCAGCCTGTAG	0.403000													20	28					0	0	1	0	0
FAM178A	0	broad.mit.edu	37	10	102683848	102683848	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:102683848C>T	ENST00000238961.3	+	5	1238	c.1090C>T	c.(1090-1092)Cgt>Tgt	p.R364C	FAM178A_ENST00000370271.3_Missense_Mutation_p.R364C|FAM178A_ENST00000370269.3_Missense_Mutation_p.R364C	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	364																	CCTTGAGAAGCGTCCTGATGG	0.393000													26	36					0	0	1	0	0
ATP5C1	509	broad.mit.edu	37	10	7841803	7841803	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:7841803C>T	ENST00000356708.7	+	5	576	c.497C>T	c.(496-498)gCg>gTg	p.A166V	ATP5C1_ENST00000541227.1_Missense_Mutation_p.A119V|ATP5C1_ENST00000493053.1_3'UTR|ATP5C1_ENST00000335698.4_Missense_Mutation_p.A166V	NM_001001973.1	NP_001001973.1	P36542	ATPG_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	166					oxidative phosphorylation|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(2)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	16						TTTGGAGATGCGTCAGTCATT	0.398000													18	39					0	0	1	0	0
NNMT	4837	broad.mit.edu	37	11	114168749	114168749	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:114168749C>A	ENST00000535401.1	+	4	495	c.231C>A	c.(229-231)tcC>tcA	p.S77S	NNMT_ENST00000299964.3_Silent_p.S77S|RP11-64D24.2_ENST00000544925.1_RNA|NNMT_ENST00000541754.1_5'UTR			P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	77					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	CTTGTGAATCCTTTAAGGAGA	0.532000													34	49					1.90571e-15	2.08616e-15	1	1	0
SDK1	221935	broad.mit.edu	37	7	4198177	4198177	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:4198177C>T	ENST00000404826.2	+	31	4862	c.4723C>T	c.(4723-4725)Cag>Tag	p.Q1575*	SDK1_ENST00000389531.3_Nonsense_Mutation_p.Q1575*	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1575					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GACCACGCTGCAGGATGGTGA	0.617000													10	19					0	0	1	0	0
NFKBIB	4793	broad.mit.edu	37	19	39398152	39398152	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39398152C>T	ENST00000392079.3	+	5	824	c.726C>T	c.(724-726)ggC>ggT	p.G242G	NFKBIB_ENST00000313582.5_Silent_p.G274G|NFKBIB_ENST00000572515.1_Silent_p.G274G			Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	274					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	8	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			TGTACGGTGGCCGCACCCCAC	0.697000													15	26					0	0	1	0	0
BTAF1	9044	broad.mit.edu	37	10	93753481	93753481	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:93753481G>T	ENST00000265990.6	+	22	3384	c.3076G>T	c.(3076-3078)Gga>Tga	p.G1026*		NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	1026					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				ACAACGGAGAGGAGCTGAATT	0.358000													26	32					6.12954e-19	6.77144e-19	1	1	0
NUP210L	91181	broad.mit.edu	37	1	154042824	154042824	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154042824G>A	ENST00000368559.3	-	17	2550	c.2479C>T	c.(2479-2481)Cta>Tta	p.L827L	NUP210L_ENST00000271854.3_Silent_p.L827L	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	827						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AAATGGGCTAGTGTTTCATTG	0.393000													49	68					0	0	1	0	0
TMEM150A	129303	broad.mit.edu	37	2	85828160	85828160	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:85828160C>T	ENST00000409668.1	-	3	651	c.184G>A	c.(184-186)Gat>Aat	p.D62N	TMEM150A_ENST00000306353.3_Silent_p.T31T|TMEM150A_ENST00000334462.5_Missense_Mutation_p.D62N			Q86TG1	T150A_HUMAN	transmembrane protein 150A	62						integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(2)|lung(1)|skin(1)	7						AGGGGGACATCGTCCAGGGTG	0.622000													3	18					0	0	1	0	0
TAS1R3	83756	broad.mit.edu	37	1	1267214	1267214	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1267214A>G	ENST00000339381.5	+	2	420	c.388A>G	c.(388-390)Aac>Gac	p.N130D		NM_152228.1	NP_689414.1	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	130					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CGCCTACTGCAACTACACGCA	0.617000													9	13					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102739701	102739701	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:102739701G>A	ENST00000210633.3	+	9	1158	c.1080G>A	c.(1078-1080)cgG>cgA	p.R360R	SEMA4G_ENST00000370250.4_Silent_p.R360R|MRPL43_ENST00000370241.3_Intron|MRPL43_ENST00000370242.4_Intron|MRPL43_ENST00000318325.2_Intron|SEMA4G_ENST00000517724.1_Silent_p.R360R			Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	360	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		ATGGTTCCCGGCGCTGGGGTC	0.642000													4	118					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129280710	129280710	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:129280710C>T	ENST00000393239.1	-	28	5040	c.4862G>A	c.(4861-4863)cGg>cAg	p.R1621Q	PLXND1_ENST00000324093.4_Missense_Mutation_p.R1621Q			Q9Y4D7	PLXD1_HUMAN	plexin D1	1621					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GTCCAGGTCCCGAAGGATGTA	0.647000													20	27					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73657797	73657797	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:73657797C>T	ENST00000263666.4	-	2	876	c.762G>A	c.(760-762)cgG>cgA	p.R254R	PDZRN3_ENST00000308537.4_Silent_p.R254R	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	254	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		AGCCGGAGTCCCGATGCAGGA	0.428000													4	10					0	0	1	0	0
CNRIP1	25927	broad.mit.edu	37	2	68521098	68521098	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:68521098G>A	ENST00000263655.3	-	3	996	c.391C>T	c.(391-393)Cgg>Tgg	p.R131W	CNRIP1_ENST00000409559.3_Intron|CNRIP1_ENST00000481714.1_5'UTR	NM_015463.2	NP_056278.1	Q96F85	CNRP1_HUMAN	cannabinoid receptor interacting protein 1	131							protein binding			kidney(1)|large_intestine(5)|liver(1)|lung(1)|skin(1)	9						CAGTGATCCCGCTTGTGGTAA	0.488000													19	33					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33137498	33137498	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:33137498C>T	ENST00000306065.4	-	4	395	c.237G>A	c.(235-237)agG>agA	p.R79R	ANKRD27_ENST00000587352.1_Silent_p.R79R|ANKRD27_ENST00000586693.2_5'UTR	NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	79					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					CTAATTTAATCCTGTTCCCTT	0.478000													11	25					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183714557	183714557	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:183714557G>A	ENST00000511685.1	+	26	6855	c.6732G>A	c.(6730-6732)caG>caA	p.Q2244Q	TENM3_ENST00000406950.2_Silent_p.Q2244Q					teneurin transmembrane protein 3																		GTCTAGGACAGCACCTGCAGT	0.448000													12	15					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33529798	33529798	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:33529798G>A	ENST00000228567.3	-	7	1835	c.1539C>T	c.(1537-1539)tcC>tcT	p.S513S	SYT10_ENST00000535526.1_Silent_p.S332S	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	513						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GAGAAGGGCAGGATCCTTGAC	0.403000													5	21					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68200917	68200917	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:68200917C>A	ENST00000349223.5	+	5	1997	c.1774_splice	c.e5+1	p.C591_splice	NFATC3_ENST00000346183.3_Splice_Site_p.C591_splice|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000575270.1_Splice_Site_p.C591_splice|NFATC3_ENST00000329524.4_Splice_Site_p.C591_splice	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	591	RHD.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		CCGTTGAGTGCTGTAAGTGAG	0.398000													34	59					3.21399e-22	3.57409e-22	1	1	0
HMCN1	83872	broad.mit.edu	37	1	185894194	185894194	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:185894194C>T	ENST00000271588.4	+	9	1530	c.1301C>T	c.(1300-1302)aCg>aTg	p.T434M	HMCN1_ENST00000367492.2_Missense_Mutation_p.T434M	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	434	Ig-like C2-type 1.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CCCAAAGTTACGATGCCTGAG	0.403000													13	9					0	0	1	0	0
CEBPG	1054	broad.mit.edu	37	19	33870419	33870419	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:33870419C>T	ENST00000284000.3	+	2	936	c.274C>T	c.(274-276)Cag>Tag	p.Q92*		NM_001252296.1|NM_001806.3	NP_001239225.1|NP_001797.1	P53567	CEBPG_HUMAN	CCAAT/enhancer binding protein (C/EBP), gamma	92					B cell differentiation|enucleate erythrocyte differentiation|liver development|natural killer cell mediated cytotoxicity|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of DNA binding|positive regulation of DNA repair|positive regulation of interferon-gamma biosynthetic process|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)	7	Esophageal squamous(110;0.137)					AGACACACTGCAGAGAGTCAA	0.438000													9	13					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238275437	238275437	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:238275437C>T	ENST00000295550.4	-	11	5845	c.5393G>A	c.(5392-5394)cGc>cAc	p.R1798H	COL6A3_ENST00000472056.1_Missense_Mutation_p.R1191H|COL6A3_ENST00000353578.4_Missense_Mutation_p.R1592H|COL6A3_ENST00000346358.4_Missense_Mutation_p.R1598H|COL6A3_ENST00000409809.1_Missense_Mutation_p.R1592H|COL6A3_ENST00000347401.3_Missense_Mutation_p.R1597H	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1798	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity	p.R1798H(1)		breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GTTGCCCACGCGGAACGCTGT	0.547000													9	67					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152815021	152815021	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:152815021G>T	ENST00000370186.1	+	9	1689	c.1363G>T	c.(1363-1365)Gcc>Tcc	p.A455S	ATP2B3_ENST00000370181.2_Missense_Mutation_p.A455S|ATP2B3_ENST00000263519.4_Missense_Mutation_p.A469S|ATP2B3_ENST00000393842.1_Missense_Mutation_p.A455S|ATP2B3_ENST00000349466.2_Missense_Mutation_p.A469S|ATP2B3_ENST00000359149.3_Missense_Mutation_p.A469S			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	469					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAACGCCACAGCCATCTGCTC	0.592000													18	7					1.99824e-07	2.09433e-07	1	1	0
KCNU1	157855	broad.mit.edu	37	8	36768621	36768621	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:36768621G>A	ENST00000399881.3	+	22	2542	c.2505G>A	c.(2503-2505)ccG>ccA	p.P835P		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	835						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CCTCTGACCCGTCACCCTCAG	0.463000													4	8					0	0	1	0	0
HOMEZ	57594	broad.mit.edu	37	14	23745398	23745398	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23745398T>G	ENST00000357460.5	-	2	1203	c.1039A>C	c.(1039-1041)Aca>Cca	p.T347P	HOMEZ_ENST00000431326.2_Missense_Mutation_p.T349P|HOMEZ_ENST00000561013.1_Missense_Mutation_p.T349P	NM_020834.2	NP_065885.2	Q8IX15	HOMEZ_HUMAN	homeobox and leucine zipper encoding	347						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		AGGTACTCTGTGGGGCCAACT	0.522000													4	87					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108175705	108175705	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:108175705T>C	ENST00000273353.3	-	20	2162	c.2106A>G	c.(2104-2106)ctA>ctG	p.L702L	MYH15_ENST00000495753.2_5'UTR	NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	702	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GCAACTGCTGTAGAACCAAGT	0.413000													39	63					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3656526	3656526	+	Missense_Mutation	SNP	G	G	A	rs142739533	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3656526G>A	ENST00000294008.3	-	3	1349	c.709C>T	c.(709-711)Cgg>Tgg	p.R237W		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	237	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						TTTTCTTCCCGCGCAGCCTCG	0.512000								Direct reversal of damage					25	171					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149212311	149212311	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149212311C>T	ENST00000309241.5	+	5	707	c.675C>T	c.(673-675)tgC>tgT	p.C225C	PPARGC1B_ENST00000403750.1_Silent_p.C161C|PPARGC1B_ENST00000360453.4_Silent_p.C186C|PPARGC1B_ENST00000394320.3_Silent_p.C225C	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	225					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CGGCACAGTGCTGCCTGCAGG	0.622000													30	41					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51239164	51239164	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:51239164C>T	ENST00000245441.5	-	9	1026	c.836G>A	c.(835-837)cGt>cAt	p.R279H	NIN_ENST00000530997.2_Missense_Mutation_p.R279H|NIN_ENST00000453196.1_Missense_Mutation_p.R279H|NIN_ENST00000389868.3_Missense_Mutation_p.R279H|NIN_ENST00000382041.3_Missense_Mutation_p.R279H|NIN_ENST00000382043.4_Missense_Mutation_p.R279H|NIN_ENST00000324330.9_Missense_Mutation_p.R279H	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	279					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					GGTTGTGGTACGTCGTCCACT	0.502000			T	PDGFRB	MPD								19	15					0	0	1	0	0
NUP85	79902	broad.mit.edu	37	17	73208112	73208112	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73208112C>T	ENST00000245544.4	+	4	387	c.316C>T	c.(316-318)Cga>Tga	p.R106*	NUP85_ENST00000447371.2_5'UTR|NUP85_ENST00000541827.1_Nonsense_Mutation_p.R60*|NUP85_ENST00000579298.1_Nonsense_Mutation_p.R106*|NUP85_ENST00000579324.1_5'UTR|NUP85_ENST00000449421.2_3'UTR	NM_024844.3	NP_079120.1	Q9BW27	NUP85_HUMAN	nucleoporin 85kDa	106					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	16	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			TAAAAACTACCGATCAGTCAT	0.448000													7	19					0	0	1	0	0
GNE	10020	broad.mit.edu	37	9	36246342	36246342	+	Missense_Mutation	SNP	C	C	T	rs144727134		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:36246342C>T	ENST00000396594.3	-	3	506	c.395G>A	c.(394-396)cGc>cAc	p.R132H	GNE_ENST00000539208.1_Missense_Mutation_p.R42H|GNE_ENST00000447283.2_Missense_Mutation_p.R101H|GNE_ENST00000539815.1_Missense_Mutation_p.R101H|GNE_ENST00000543356.2_Missense_Mutation_p.R96H|GNE_ENST00000377902.5_Missense_Mutation_p.R101H	NM_001128227.2	NP_001121699.1	Q9Y223	GLCNE_HUMAN	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	101			H -> Q (in NM).		cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			STAD - Stomach adenocarcinoma(86;0.228)			AGGCTTCAGGCGATTAAGGAC	0.502000													20	30					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46724280	46724280	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46724280C>T	ENST00000311764.2	+	3	587	c.357C>T	c.(355-357)gaC>gaT	p.D119D		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CATGGGGAGACGTGTGTGCCT	0.473000													35	64					0	0	1	0	0
MVB12B	89853	broad.mit.edu	37	9	129148856	129148856	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:129148856G>A	ENST00000361171.3	+	4	409	c.328G>A	c.(328-330)Gtg>Atg	p.V110M	MVB12B_ENST00000535766.1_Missense_Mutation_p.V103M|MVB12B_ENST00000436593.3_Missense_Mutation_p.V95M|MVB12B_ENST00000545391.1_Missense_Mutation_p.V110M	NM_033446.2	NP_258257.1			multivesicular body subunit 12B																		TCTGGGGAACGTGTTAGTAGA	0.443000													8	20					0	0	1	0	0
VPS52	6293	broad.mit.edu	37	6	33236315	33236315	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33236315G>A	ENST00000445902.2	-	7	878	c.660C>T	c.(658-660)tgC>tgT	p.C220C	VPS52_ENST00000436044.2_Silent_p.C95C|VPS52_ENST00000482399.1_3'UTR|VPS52_ENST00000478934.1_5'UTR	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	220					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						TGACATCTGCGCAGGCTGCTG	0.597000													24	29					0	0	1	0	0
KLHL10	317719	broad.mit.edu	37	17	39998228	39998228	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39998228A>G	ENST00000293303.4	+	2	501	c.348A>G	c.(346-348)gcA>gcG	p.A116A	KLHL10_ENST00000485613.1_3'UTR	NM_152467.3	NP_689680.2	Q6JEL2	KLH10_HUMAN	kelch-like family member 10	116						cytoplasm				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26		Breast(137;0.000162)				TTGCTGCTGCAGACCAGTTTA	0.493000													17	68					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57092918	57092918	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57092918C>A	ENST00000436936.1	+	29	4090	c.3865C>A	c.(3865-3867)Ctg>Atg	p.L1289M	NLRC5_ENST00000262510.6_Missense_Mutation_p.L1289M|NLRC5_ENST00000539144.1_Missense_Mutation_p.L1260M|NLRC5_ENST00000308149.7_Missense_Mutation_p.L1260M			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	1289					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				GGAAAGTGCCCTGTACCTGCT	0.587000													56	92					2.69953e-25	3.01344e-25	1	1	0
TRIM71	131405	broad.mit.edu	37	3	32932570	32932570	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:32932570G>A	ENST00000383763.4	+	4	1937	c.1874G>A	c.(1873-1875)cGc>cAc	p.R625H		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	625					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GTCGCCGACCGCAGCAACAAC	0.652000													10	9					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33875362	33875362	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:33875362G>T	ENST00000374408.3	-	4	1316	c.1220C>A	c.(1219-1221)cCt>cAt	p.P407H		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	407										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			ATAGAGCCCAGGAGGGGAGCC	0.627000													11	9					3.86212e-05	3.97146e-05	1	1	0
PCLO	27445	broad.mit.edu	37	7	82584469	82584469	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:82584469C>T	ENST00000423517.2	-	5	6137	c.5800G>A	c.(5800-5802)Gca>Aca	p.A1934T	PCLO_ENST00000333891.8_Missense_Mutation_p.A1934T	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1865					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CGTTCATTTGCAGCTGGAAAA	0.358000													6	27					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42273290	42273290	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:42273290C>T	ENST00000379310.3	-	29	3549	c.3481G>A	c.(3481-3483)Gcc>Acc	p.A1161T		NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		ACGCCATTGGCTGTTCTTGGG	0.473000													32	44					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46851338	46851338	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:46851338G>T	ENST00000283296.7	-	6	858	c.570C>A	c.(568-570)tcC>tcA	p.S190S	GPR116_ENST00000265417.7_Silent_p.S190S|GPR116_ENST00000456426.2_Silent_p.S190S|GPR116_ENST00000362015.4_Silent_p.S190S	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	190	SEA.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			AGAGGGCGGAGGAAGTGTTCA	0.423000													11	29					0.000673444	0.000685014	1	1	0
SPAG5	10615	broad.mit.edu	37	17	26904749	26904749	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26904749C>A	ENST00000321765.5	-	24	3882	c.3550G>T	c.(3550-3552)Gaa>Taa	p.E1184*		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	1184					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					CCCTGTAGTTCTTTGCATCCC	0.512000													28	34					1.30897e-18	1.44543e-18	1	1	0
BAGE2	85319	broad.mit.edu	37	21	11058296	11058296	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:11058296C>T	ENST00000470054.1	-	0	351									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTGATAGTGGCTCCAAAGTGC	0.408000													11	190					0	0	1	0	0
RP3-402G11.5	0	broad.mit.edu	37	22	50649339	50649339	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50649339C>T	ENST00000380903.2	+	5	1408	c.1351_splice	c.e5+1	p.T450_splice	RP3-402G11.5_ENST00000492092.1_3'UTR	NM_031454.1	NP_113642.1																					TGCATCTGACCGGTGAGTGAC	0.602000											OREG0026676	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	65					0	0	1	0	0
COBLL1	22837	broad.mit.edu	37	2	165548758	165548758	+	Silent	SNP	C	C	T	rs143772614	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:165548758C>T	ENST00000375458.2	-	12	3494	c.3273G>A	c.(3271-3273)tcG>tcA	p.S1091S	COBLL1_ENST00000194871.6_Silent_p.S1196S|COBLL1_ENST00000392717.2_Silent_p.S1167S|COBLL1_ENST00000409184.3_Silent_p.S1129S|COBLL1_ENST00000342193.4_Silent_p.S1129S	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	1167										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						CAGCCTCTCCCGAACGGATTG	0.428000													5	43					0	0	1	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65205538	65205538	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:65205538C>T	ENST00000247226.7	+	13	1623	c.1315C>T	c.(1315-1317)Cgc>Tgc	p.R439C	PLEKHG3_ENST00000394691.1_Missense_Mutation_p.R495C|PLEKHG3_ENST00000471182.2_Missense_Mutation_p.R28C|PLEKHG3_ENST00000484731.2_5'UTR	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	495					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TACTGAGAAGCGCATGAGCTT	0.567000													5	5					0	0	1	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105924480	105924480	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:105924480C>T	ENST00000393359.2	-	2	705	c.279G>A	c.(277-279)gtG>gtA	p.V93V	TGFBRAP1_ENST00000258449.1_Silent_p.V93V			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	93	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						TGTCACACAGCACCAGCAGCC	0.602000													7	38					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27420010	27420010	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27420010G>A	ENST00000527372.1	-	33	5116	c.4936C>T	c.(4936-4938)Cgg>Tgg	p.R1646W	MYO18A_ENST00000354329.4_Missense_Mutation_p.R1646W|MYO18A_ENST00000533112.1_Missense_Mutation_p.R1609W|MYO18A_ENST00000531253.1_Missense_Mutation_p.R1646W	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	1646					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TCAAAGTCCCGCCGGTTCACC	0.612000													19	19					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43910131	43910131	+	Translation_Start_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43910131C>T	ENST00000541030.1	-	0	563				STRC_ENST00000450892.2_Missense_Mutation_p.R163H			Q7RTU9	STRC_HUMAN	stereocilin						sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		CGGCCCATCACGGGTGCATGG	0.652000													5	71					0	0	1	0	0
PAPOLB	56903	broad.mit.edu	37	7	4901260	4901260	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:4901260C>T	ENST00000404991.1	-	1	365	c.179G>A	c.(178-180)cGc>cAc	p.R60H	RADIL_ENST00000536091.1_Intron|RADIL_ENST00000399583.3_Intron	NM_020144.4	NP_064529.4	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	60					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			kidney(1)|large_intestine(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		TAAAATCCTGCGCTGCAGTTC	0.473000													8	25					0	0	1	0	0
MAPKAP1	79109	broad.mit.edu	37	9	128230310	128230310	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:128230310G>A	ENST00000265960.3	-	10	1618	c.1286C>T	c.(1285-1287)cCc>cTc	p.P429L	MAPKAP1_ENST00000373498.1_Missense_Mutation_p.P429L|MAPKAP1_ENST00000373511.2_Missense_Mutation_p.P382L|MAPKAP1_ENST00000483937.1_5'UTR|MAPKAP1_ENST00000373503.3_Missense_Mutation_p.P237L|MAPKAP1_ENST00000373497.5_Missense_Mutation_p.P142L|MAPKAP1_ENST00000350766.3_Missense_Mutation_p.P393L|MAPKAP1_ENST00000394063.1_Missense_Mutation_p.P237L	NM_001006617.1	NP_001006618.1	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated protein 1	429					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(3)	23						GATTGAGATGGGTTTCTGCTT	0.458000													26	39					0	0	1	0	0
XAB2	56949	broad.mit.edu	37	19	7687517	7687517	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:7687517C>T	ENST00000358368.4	-	11	1439	c.1402G>A	c.(1402-1404)Gag>Aag	p.E468K	XAB2_ENST00000534844.1_Missense_Mutation_p.E465K	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	468					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						TCAAAGTACTCGGCCCGGCGG	0.667000								Direct reversal of damage;Nucleotide excision repair (NER)					15	28					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141052155	141052155	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:141052155C>T	ENST00000239440.4	-	9	1414	c.1349G>A	c.(1348-1350)cGa>cAa	p.R450Q	ARAP3_ENST00000508305.1_Missense_Mutation_p.R372Q|ARAP3_ENST00000513878.1_Missense_Mutation_p.R112Q	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	450	PH 2.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						GTCAAAGCTTCGACTCTTGGT	0.637000													10	13					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78341603	78341603	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78341603G>A	ENST00000582970.1	+	43	12070	c.11927G>A	c.(11926-11928)cGc>cAc	p.R3976H	CTD-2047H16.4_ENST00000575034.1_RNA|RNF213_ENST00000336301.6_Missense_Mutation_p.R2049H|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000508628.2_Missense_Mutation_p.R4025H	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GCCGTGATGCGCACTCTCTGT	0.547000													4	35					0	0	1	0	0
DNAJC3	5611	broad.mit.edu	37	13	96443194	96443194	+	Silent	SNP	C	C	T	rs3087338	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:96443194C>T	ENST00000602402.1	+	12	1542	c.1425C>T	c.(1423-1425)ggC>ggT	p.G475G	DNAJC3_ENST00000376795.6_Silent_p.G424G	NM_006260.4	NP_006251.1	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	475					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding			NS(1)|breast(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			GAGGCGGCGGCAACCCTTTCC	0.438000													34	15					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175630	159175630	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:159175630G>A	ENST00000537147.1	+	3	1244	c.401G>A	c.(400-402)tGt>tAt	p.C134Y	DARC_ENST00000368122.2_Missense_Mutation_p.C134Y|DARC_ENST00000368121.2_Missense_Mutation_p.C136Y			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	134					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					CTGGGCTACTGTGTCTGGTAT	0.647000													8	15					0	0	1	0	0
KDELC1	79070	broad.mit.edu	37	13	103443702	103443702	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:103443702G>T	ENST00000376004.4	-	5	1087	c.751C>A	c.(751-753)Cat>Aat	p.H251N	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	251						endoplasmic reticulum lumen				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AAGATCGGATGGATGTTTGAA	0.443000													26	211					3.73808e-20	4.14251e-20	1	1	0
SLU7	10569	broad.mit.edu	37	5	159834777	159834777	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:159834777T>C	ENST00000297151.4	-	10	1348	c.961A>G	c.(961-963)Acc>Gcc	p.T321A		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	321					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATTGAAATGGTATCTCCTGTG	0.333000													6	134					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45567115	45567115	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:45567115C>T	ENST00000588982.1	-	3	865	c.364G>A	c.(364-366)Gtg>Atg	p.V122M	ZBTB7C_ENST00000586438.1_Missense_Mutation_p.V122M|ZBTB7C_ENST00000332053.2_Missense_Mutation_p.V122M|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.V122M|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.V122M			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	122						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						TCCAGGCACACGTTCACGATG	0.587000													4	23					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29735056	29735056	+	Missense_Mutation	SNP	C	C	T	rs145640648	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:29735056C>T	ENST00000357586.2	-	16	2272	c.2086G>A	c.(2086-2088)Ggc>Agc	p.G696S	AP1B1_ENST00000432560.2_Missense_Mutation_p.G689S|AP1B1_ENST00000415447.1_Missense_Mutation_p.G689S|AP1B1_ENST00000356015.2_Missense_Mutation_p.G689S|AP1B1_ENST00000402502.1_Missense_Mutation_p.G689S|AP1B1_ENST00000405198.1_Missense_Mutation_p.G696S|AP1B1_ENST00000472057.1_5'UTR|AP1B1_ENST00000317368.7_Missense_Mutation_p.G689S	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	696	Pro-rich (stalk region).				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						AGGCCACTGCCGATGGGTGCT	0.567000													44	48					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881665	26881665	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:26881665G>A	ENST00000231021.4	-	12	2122	c.1950C>T	c.(1948-1950)gaC>gaT	p.D650D		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	650					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CCCGGACATCGTCTTTTGAAA	0.408000													47	53					0	0	1	0	0
ZBED1	9189	broad.mit.edu	37	X	2407908	2407908	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:2407908C>T	ENST00000381223.4	-	2	1056	c.853G>A	c.(853-855)Gca>Aca	p.A285T	DHRSX_ENST00000334651.5_Intron|ZBED1_ENST00000381222.2_Missense_Mutation_p.A285T|ZBED1_ENST00000381218.3_Missense_Mutation_p.A285T	NM_001171135.1|NM_001171136.1|NM_004729.3	NP_001164606.1|NP_001164607.1|NP_004720.1	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	285						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	25		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATGTGCACTGCGACGTCCAGC	0.637000													36	68					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60904261	60904261	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:60904261G>A	ENST00000252999.3	-	33	4234	c.4168C>T	c.(4168-4170)Cgg>Tgg	p.R1390W		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1390	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCTCCTCCCGGAGGTAGCCA	0.637000													22	40					0	0	1	0	0
SLC1A4	6509	broad.mit.edu	37	2	65243582	65243582	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:65243582C>A	ENST00000234256.3	+	5	1052	c.809C>A	c.(808-810)cCt>cAt	p.P270H	SLC1A4_ENST00000493121.1_3'UTR|SLC1A4_ENST00000531327.1_Intron	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	270					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|urinary_tract(1)	13					L-Alanine(DB00160)	AGGTACGTACCTGTGGGCATC	0.507000													14	45					4.3838e-07	4.58243e-07	1	1	0
STARD10	10809	broad.mit.edu	37	11	72470359	72470359	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:72470359C>T	ENST00000334805.6	-	3	1194	c.275G>A	c.(274-276)cGc>cAc	p.R92H	STARD10_ENST00000538437.1_5'UTR|STARD10_ENST00000538536.1_Missense_Mutation_p.R46H|ARAP1_ENST00000359373.5_Intron|STARD10_ENST00000545082.1_Missense_Mutation_p.R63H|STARD10_ENST00000543304.1_Missense_Mutation_p.R92H	NM_006645.2	NP_006636.2	Q9Y365	PCTL_HUMAN	StAR-related lipid transfer (START) domain containing 10	92	START.									endometrium(4)|large_intestine(1)|lung(2)|prostate(1)	8			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			CCATTTCTTGCGGTACTCAAT	0.527000													28	52					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127614381	127614381	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:127614381C>T	ENST00000508053.1	-	63	8265	c.7291G>A	c.(7291-7293)Gcc>Acc	p.A2431T	FBN2_ENST00000262464.4_Missense_Mutation_p.A2431T			P35556	FBN2_HUMAN	fibrillin 2	2431	TB 9.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTGTACTGGGCAGTTCCAGGA	0.468000													7	60					0	0	1	0	0
BTN2A2	10385	broad.mit.edu	37	6	26392674	26392674	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:26392674C>T	ENST00000356709.4	+	8	1162	c.1051C>T	c.(1051-1053)Cgg>Tgg	p.R351W	BTN2A2_ENST00000416795.2_Missense_Mutation_p.R351W|BTN2A2_ENST00000352867.2_Missense_Mutation_p.R235W|BTN2A2_ENST00000432533.2_3'UTR|BTN2A2_ENST00000469230.1_Intron|BTN2A2_ENST00000482536.1_Missense_Mutation_p.R141W	NM_001197240.1|NM_006995.4	NP_001184169.1|NP_008926.2	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2	351	B30.2/SPRY.				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane				breast(2)|endometrium(3)|large_intestine(5)|lung(13)	23						AAGTGTGAGGCGGGGCCCCTA	0.577000													12	42					0	0	1	0	0
GPR101	83550	broad.mit.edu	37	X	136113733	136113733	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:136113733C>T	ENST00000298110.1	-	1	100	c.101G>A	c.(100-102)cGc>cAc	p.R34H		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	34						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					CACGGTTGAGCGGATGATGCC	0.607000													32	7					0	0	1	0	0
HAX1	10456	broad.mit.edu	37	1	154245979	154245979	+	Missense_Mutation	SNP	G	G	A	rs151225652		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154245979G>A	ENST00000328703.7	+	2	434	c.221G>A	c.(220-222)cGt>cAt	p.R74H	HAX1_ENST00000457918.2_Missense_Mutation_p.R26H|HAX1_ENST00000532105.1_Intron|HAX1_ENST00000483970.2_Missense_Mutation_p.R74H	NM_006118.3	NP_006109.2	O00165	HAX1_HUMAN	HCLS1 associated protein X-1	74						actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	15	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGAGGGATACGTTTCCACGAT	0.562000									Kostmann syndrome				15	23					0	0	1	0	0
AMER1	139285	broad.mit.edu	37	X	63410418	63410418	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:63410418C>T	ENST00000330258.3	-	2	3021	c.2749G>A	c.(2749-2751)Gag>Aag	p.E917K	AMER1_ENST00000403336.1_Intron|AMER1_ENST00000374869.3_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									TCATCAGACTCGAGGTAGCCC	0.567000													11	28					0	0	1	0	0
GJC2	57165	broad.mit.edu	37	1	228345790	228345790	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228345790C>T	ENST00000366714.2	+	2	506	c.331C>T	c.(331-333)Cgc>Tgc	p.R111C		NM_020435.3	NP_065168.2	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	111					cell death	connexon complex|integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Prostate(94;0.0405)				GCAGGAgcggcgccgcgccct	0.766000													13	3					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62550224	62550224	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:62550224G>A	ENST00000371158.2	+	33	4395	c.4281G>A	c.(4279-4281)acG>acA	p.T1427T	INADL_ENST00000543708.1_Silent_p.T211T|INADL_ENST00000545929.1_Silent_p.T100T|INADL_ENST00000316485.6_Silent_p.T1427T	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1427					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						ACCCCGCAACGTGTCCCATTG	0.512000													33	38					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143097138	143097138	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:143097138C>T	ENST00000275815.3	-	4	527	c.441G>A	c.(439-441)acG>acA	p.T147T		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	147						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CTGCAGCCACCGTGGTTACCT	0.552000													9	11					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29630489	29630489	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:29630489G>A	ENST00000318184.5	-	10	1091	c.1092C>T	c.(1090-1092)gaC>gaT	p.D364D	OVCH1-AS1_ENST00000551108.1_Intron|OVCH1-AS1_ENST00000549411.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	364	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GTTTTCCATCGTCTTCCATGA	0.358000													7	17					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165984285	165984285	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:165984285G>A	ENST00000360093.3	-	18	3740	c.3249C>T	c.(3247-3249)taC>taT	p.Y1083Y	SCN3A_ENST00000409101.3_Silent_p.Y1034Y|SCN3A_ENST00000283254.7_Silent_p.Y1083Y	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1083						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CATCGATTACGTATTTTTCAA	0.378000													34	35					0	0	1	0	0
MX1	4599	broad.mit.edu	37	21	42823102	42823102	+	Missense_Mutation	SNP	C	C	T	rs149908360		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:42823102C>T	ENST00000398600.2	+	17	2466	c.1441C>T	c.(1441-1443)Cgg>Tgg	p.R481W	MX1_ENST00000455164.2_Missense_Mutation_p.R481W|MX1_ENST00000398598.3_Missense_Mutation_p.R481W|MX1_ENST00000288383.6_Missense_Mutation_p.R458W	NM_001144925.1	NP_001138397.1	P20591	MX1_HUMAN	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	481					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	27		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				AGATATGGTCCGGCTTGCTTT	0.323000													47	30					0	0	1	0	0
LYVE1	10894	broad.mit.edu	37	11	10580686	10580686	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:10580686G>A	ENST00000256178.3	-	6	1099	c.941C>T	c.(940-942)aCc>aTc	p.T314I	LYVE1_ENST00000529598.1_Missense_Mutation_p.T210I|MRVI1-AS1_ENST00000529979.1_RNA|MRVI1-AS1_ENST00000529829.1_RNA	NM_006691.3	NP_006682.2	Q9Y5Y7	LYVE1_HUMAN	lymphatic vessel endothelial hyaluronan receptor 1	314					anatomical structure morphogenesis|cell-matrix adhesion|cellular component movement|response to wounding|transport	integral to plasma membrane|membrane fraction				central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8				all cancers(16;7.22e-08)|Epithelial(150;1.03e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0609)		GCATCGCACGGTAGTTTTGCT	0.463000													85	91					0	0	1	0	0
PEA15	8682	broad.mit.edu	37	1	160182919	160182919	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160182919G>A	ENST00000368076.1	+	5	603	c.255G>A	c.(253-255)gaG>gaA	p.E85E	PEA15_ENST00000488858.1_3'UTR|PEA15_ENST00000368077.1_Silent_p.E42E|PEA15_ENST00000360472.4_Silent_p.E64E			Q15121	PEA15_HUMAN	phosphoprotein enriched in astrocytes 15	64					anti-apoptosis|apoptosis|carbohydrate transport|negative regulation of glucose import	cytoplasm|microtubule associated complex	protein binding			large_intestine(1)|lung(4)	5	all_cancers(52;3.11e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCTACATTGAGCACATCTTTG	0.537000													6	66					0	0	1	0	0
RHBDD2	57414	broad.mit.edu	37	7	75517369	75517369	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:75517369G>T	ENST00000318622.4	+	5	1003	c.374G>T	c.(373-375)aGc>aTc	p.S125I	RHBDD2_ENST00000006777.6_Missense_Mutation_p.S266I|RHBDD2_ENST00000468304.1_3'UTR|RHBDD2_ENST00000428119.1_Missense_Mutation_p.S125I	NM_001040457.1	NP_001035547.1	Q6NTF9	RHBD2_HUMAN	rhomboid domain containing 2	266						integral to membrane	serine-type endopeptidase activity			kidney(1)|lung(4)|prostate(1)	6						CTGTCCCCAAGCCACCCTGTG	0.632000													27	45					1.5548e-18	1.71633e-18	1	1	0
BRCA1	672	broad.mit.edu	37	17	41226394	41226394	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41226394C>T	ENST00000309486.4	-	13	4768	c.3741G>A	c.(3739-3741)ggG>ggA	p.G1247G	BRCA1_ENST00000346315.3_Intron|BRCA1_ENST00000493795.1_Silent_p.G1496G|BRCA1_ENST00000491747.2_Silent_p.G439G|BRCA1_ENST00000468300.1_Silent_p.G439G|BRCA1_ENST00000471181.2_Silent_p.G1564G|BRCA1_ENST00000357654.3_Silent_p.G1543G|BRCA1_ENST00000591534.1_Silent_p.G34G|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000351666.3_Silent_p.G360G|BRCA1_ENST00000352993.3_Silent_p.G401G|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000354071.3_Intron	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	1543					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AATCGTGTGGCCCAGACTCTT	0.433000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			23	25					0	0	1	0	0
CHRNA6	8973	broad.mit.edu	37	8	42614217	42614217	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:42614217G>A	ENST00000276410.2	-	3	614	c.259C>T	c.(259-261)Cgt>Tgt	p.R87C	CHRNA6_ENST00000534622.1_Intron|CHRNA6_ENST00000530869.1_5'UTR	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	87						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CATACGTGACGCAGCCACAAA	0.393000													21	53					0	0	1	0	0
MRPS2	51116	broad.mit.edu	37	9	138395974	138395974	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:138395974C>A	ENST00000371785.1	+	5	1095	c.886C>A	c.(886-888)Ctg>Atg	p.L296M	MRPS2_ENST00000241600.5_Missense_Mutation_p.L296M|RP11-426A6.5_ENST00000415062.1_RNA			Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	296					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome			large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)		GAGCCATTCCCTGTGATGTTC	0.637000													3	8					0.115264	0.115739	1	1	0
TICRR	90381	broad.mit.edu	37	15	90137697	90137697	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:90137697C>T	ENST00000268138.7	+	6	1698	c.1593C>T	c.(1591-1593)ggC>ggT	p.G531G	TICRR_ENST00000560985.1_Silent_p.G530G					TOPBP1-interacting checkpoint and replication regulator																		AAACTGAAGGCGAATTAATAC	0.393000													25	23					0	0	1	0	0
PAPD5	64282	broad.mit.edu	37	16	50245299	50245299	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:50245299G>A	ENST00000357464.3	+	3	422	c.422G>A	c.(421-423)cGg>cAg	p.R141Q	PAPD5_ENST00000436909.3_Missense_Mutation_p.R220Q|PAPD5_ENST00000561678.1_Missense_Mutation_p.R153Q			Q8NDF8	PAPD5_HUMAN	PAP associated domain containing 5	141					cell division|DNA replication|histone mRNA catabolic process|mitosis	cytoplasm|nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding			endometrium(1)|kidney(1)|lung(2)	4		all_cancers(37;0.0452)		BRCA - Breast invasive adenocarcinoma(181;0.0843)|GBM - Glioblastoma multiforme(240;0.231)		GAGAAGATGCGGATGGAGGTG	0.458000													11	20					0	0	1	0	0
MVK	4598	broad.mit.edu	37	12	110034289	110034289	+	Silent	SNP	C	C	T	rs104895372		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:110034289C>T	ENST00000228510.3	+	11	1174	c.1098C>T	c.(1096-1098)gaC>gaT	p.D366D	MVK_ENST00000392727.3_Silent_p.D314D|MVK_ENST00000541384.1_Silent_p.D172D|MVK_ENST00000539575.1_Silent_p.D314D|MVK_ENST00000539696.1_Silent_p.D85D	NM_000431.2|NM_001114185.1	NP_000422.1|NP_001107657.1	Q03426	KIME_HUMAN	mevalonate kinase	366					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8						GTGGCTTTGACTGCTTGGAAA	0.647000													7	29					0	0	1	0	0
WNT7A	7476	broad.mit.edu	37	3	13916637	13916637	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:13916637G>A	ENST00000285018.4	-	2	409	c.105C>T	c.(103-105)agC>agT	p.S35S	WNT7A_ENST00000497808.1_5'UTR	NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	35				S -> T (in Ref. 1; AAC51319).	activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						TACAGATGATGCTTGCGCCCA	0.602000													10	15					0	0	1	0	0
ARF1	375	broad.mit.edu	37	1	228285129	228285129	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228285129C>T	ENST00000541182.1	+	3	497	c.235C>T	c.(235-237)Cgc>Tgc	p.R79C	ARF1_ENST00000478424.1_3'UTR|ARF1_ENST00000540651.1_Missense_Mutation_p.R79C|ARF1_ENST00000272102.5_Missense_Mutation_p.R79C	NM_001024227.1|NM_001024228.1	NP_001019398.1|NP_001019399.1	P84077	ARF1_HUMAN	ADP-ribosylation factor 1	79					cellular copper ion homeostasis|COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|protein transport|regulation of defense response to virus by virus|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction|viral reproduction	cytosol|Golgi membrane|perinuclear region of cytoplasm|plasma membrane	GTP binding|GTPase activity|protein binding|receptor signaling protein activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)	10		Prostate(94;0.0405)				GCCCCTGTGGCGCCACTACTT	0.607000													18	25					0	0	1	0	0
CACNB2	783	broad.mit.edu	37	10	18828568	18828568	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:18828568G>A	ENST00000396576.2	+	13	2234	c.1733G>A	c.(1732-1734)cGc>cAc	p.R578H	CACNB2_ENST00000377315.4_Missense_Mutation_p.R585H|CACNB2_ENST00000377331.2_Missense_Mutation_p.R581H|RP11-499P20.2_ENST00000425669.1_RNA|CACNB2_ENST00000352115.6_Missense_Mutation_p.R609H|CACNB2_ENST00000377319.3_Missense_Mutation_p.R540H|CACNB2_ENST00000282343.8_Missense_Mutation_p.R605H|CACNB2_ENST00000324631.7_Missense_Mutation_p.R633H|CACNB2_ENST00000377328.1_Missense_Mutation_p.R383H|CACNB2_ENST00000377329.4_Missense_Mutation_p.R579H	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	633					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCCAAGGATCGCTACTGTGAA	0.527000													4	57					0	0	1	0	0
PARM1	25849	broad.mit.edu	37	4	75937973	75937973	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:75937973G>A	ENST00000307428.7	+	2	594	c.382G>A	c.(382-384)Ggc>Agc	p.G128S	PARM1_ENST00000513238.1_Intron|RP11-44F21.2_ENST00000513770.1_RNA	NM_015393.3	NP_056208.2	Q6UWI2	PARM1_HUMAN	prostate androgen-regulated mucin-like protein 1	128					positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				cervix(1)|endometrium(2)|lung(4)|ovary(1)	8						ACACAGCTCGGGCACTCCTGA	0.577000													23	37					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51135606	51135606	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:51135606C>A	ENST00000338916.4	-	2	1244	c.611G>T	c.(610-612)aGt>aTt	p.S204I	SYT3_ENST00000600079.1_Missense_Mutation_p.S204I|SYT3_ENST00000593901.1_Missense_Mutation_p.S204I|SYT3_ENST00000544769.1_Missense_Mutation_p.S204I	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	204						cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		GCCCCCACCACTGGGGGGCAG	0.647000													25	15					7.92952e-12	8.55149e-12	1	1	0
FAM47B	170062	broad.mit.edu	37	X	34961471	34961471	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:34961471G>T	ENST00000329357.5	+	1	559	c.523G>T	c.(523-525)Gta>Tta	p.V175L		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	175										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GACAACCGAGGTACCCACCGA	0.617000													9	6					2.17888e-05	2.24846e-05	1	1	0
CDC25A	993	broad.mit.edu	37	3	48200534	48200534	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48200534C>T	ENST00000302506.3	-	15	1884	c.1476G>A	c.(1474-1476)gaG>gaA	p.E492E	CDC25A_ENST00000351231.3_Silent_p.E452E	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	492					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		CTTTAAAGTCCTCGTGGTGCA	0.552000													13	17					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51720866	51720866	+	Missense_Mutation	SNP	G	G	A	rs78361537	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:51720866G>A	ENST00000371117.3	-	49	8011	c.7736C>T	c.(7735-7737)gCg>gTg	p.A2579V	PKHD1_ENST00000340994.4_Missense_Mutation_p.A2579V	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2579					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AGGAGTATTCGCTCTAAGGTG	0.353000													28	50					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138330060	138330060	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:138330060C>T	ENST00000409968.1	+	17	3535	c.3357C>T	c.(3355-3357)tcC>tcT	p.S1119S	THSD7B_ENST00000272643.3_Silent_p.S1122S|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Silent_p.S1091S					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AAACCCAGTCCTGTTCTCTTA	0.463000													12	18					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40558610	40558610	+	Missense_Mutation	SNP	C	C	T	rs143324236		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40558610C>T	ENST00000455577.2	+	5	1684	c.772C>T	c.(772-774)Cgc>Tgc	p.R258C	PAK6_ENST00000542403.2_Missense_Mutation_p.R258C|PAK6_ENST00000560346.1_Missense_Mutation_p.R258C|RP11-133K1.2_ENST00000558658.1_3'UTR|PAK6_ENST00000441369.1_Missense_Mutation_p.R258C|PAK6_ENST00000559901.1_3'UTR|PAK6_ENST00000260404.4_Missense_Mutation_p.R258C|PAK6_ENST00000453867.1_Missense_Mutation_p.R258C	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	258	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		CAGCCTGAAGCGCAGGCTATT	0.652000													7	13					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65412536	65412536	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65412536C>A	ENST00000394224.3	+	5	1391	c.1095C>A	c.(1093-1095)acC>acA	p.T365T	SIPA1_ENST00000534313.1_Silent_p.T365T|SIPA1_ENST00000394227.3_Silent_p.T365T|SIPA1_ENST00000527525.1_Silent_p.T365T	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	365	Rap-GAP.				cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						AGTTTCTCACCTTGCTGGGCG	0.622000													25	54					9.90768e-06	1.02613e-05	1	1	0
OR2W5	0	broad.mit.edu	37	1	247654839	247654839	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247654839G>A	ENST00000522351.1	+	0	470							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GCAGTCATGCGCCCACATCTC	0.592000													23	18					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167379716	167379716	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:167379716G>A	ENST00000519204.1	+	3	591	c.473G>A	c.(472-474)cGg>cAg	p.R158Q	CTC-353G13.1_ENST00000523050.1_RNA|TENM2_ENST00000403607.2_Missense_Mutation_p.R112Q|TENM2_ENST00000545108.1_Missense_Mutation_p.R279Q|TENM2_ENST00000520394.1_Missense_Mutation_p.R88Q|TENM2_ENST00000518659.1_Missense_Mutation_p.R279Q|TENM2_ENST00000520393.1_3'UTR					teneurin transmembrane protein 2																		ACCAATCGGCGGAGTCAGATC	0.627000													3	7					0	0	1	0	0
MED15	51586	broad.mit.edu	37	22	20929464	20929464	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:20929464C>T	ENST00000263205.7	+	9	1286	c.1217C>T	c.(1216-1218)gCt>gTt	p.A406V	MED15_ENST00000541476.1_Intron|MED15_ENST00000425759.2_Intron|MED15_ENST00000292733.7_Intron|MED15_ENST00000382974.2_Intron|MED15_ENST00000478831.1_Intron|MED15_ENST00000542773.1_Intron|MED15_ENST00000406969.1_Intron	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	406	Pro-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			CCTACCACCGCTGTGTCCGCC	0.627000													4	64					0	0	1	0	0
SHISA2	387914	broad.mit.edu	37	13	26620664	26620664	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:26620664G>A	ENST00000319420.3	-	2	930	c.875C>T	c.(874-876)gCg>gTg	p.A292V		NM_001007538.1	NP_001007539.1	Q6UWI4	SHSA2_HUMAN	shisa family member 2	292					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)|skin(1)	17						TACAGTCACCGCTGGGTACAT	0.557000													25	28					0	0	1	0	0
POGZ	23126	broad.mit.edu	37	1	151380973	151380973	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151380973C>T	ENST00000271715.2	-	14	2460	c.2146G>A	c.(2146-2148)Gca>Aca	p.A716T	POGZ_ENST00000368863.2_Missense_Mutation_p.A621T|POGZ_ENST00000361398.3_Missense_Mutation_p.A663T|POGZ_ENST00000392723.1_Missense_Mutation_p.A663T|POGZ_ENST00000409503.1_Missense_Mutation_p.A707T|POGZ_ENST00000540984.1_Missense_Mutation_p.A78T|POGZ_ENST00000491586.1_Missense_Mutation_p.A672T|POGZ_ENST00000531094.1_Missense_Mutation_p.A654T	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	716					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTCAGCGGTGCTGCCTCCTGC	0.567000													7	72					0	0	1	0	0
KIAA0355	9710	broad.mit.edu	37	19	34791438	34791438	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:34791438C>T	ENST00000299505.6	+	2	933	c.60C>T	c.(58-60)ggC>ggT	p.G20G		NM_014686.3	NP_055501.2	O15063	K0355_HUMAN	KIAA0355	20								p.G20G(1)		breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					TCCTGCTTGGCGGGTCCAAGC	0.622000													19	14					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119133271	119133271	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:119133271G>A	ENST00000264245.4	+	12	3027	c.2495G>A	c.(2494-2496)aGc>aAc	p.S832N		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	832					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						GAGATCTCTAGCCTCTGTCAG	0.512000													22	24					0	0	1	0	0
FBXW8	26259	broad.mit.edu	37	12	117465865	117465865	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:117465865C>T	ENST00000455858.2	+	11	1560	c.1487C>T	c.(1486-1488)gCg>gTg	p.A496V	FBXW8_ENST00000309909.5_Missense_Mutation_p.A562V	NM_012174.1|NM_153348.2	NP_036306.1|NP_699179.2	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8	562							protein binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	22	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		TATGAGTTTGCGGTGGACCAG	0.612000													14	18					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33588460	33588460	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:33588460C>T	ENST00000404816.2	+	29	4627	c.4274C>T	c.(4273-4275)gCa>gTa	p.A1425V	LTBP1_ENST00000354476.3_Missense_Mutation_p.A1426V|LTBP1_ENST00000272273.5_Missense_Mutation_p.A323V|LTBP1_ENST00000390003.4_Missense_Mutation_p.A1100V|LTBP1_ENST00000418533.2_Missense_Mutation_p.A1057V|LTBP1_ENST00000402934.1_Missense_Mutation_p.A1044V|LTBP1_ENST00000404525.1_Missense_Mutation_p.A1046V|LTBP1_ENST00000407925.1_Missense_Mutation_p.A1099V			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1425	EGF-like 15; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CCCGTAGATGCAGATGAATGC	0.363000													11	62					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519788	113519788	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:113519788T>C	ENST00000284601.3	-	4	1427	c.1359A>G	c.(1357-1359)atA>atG	p.I453M		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	453					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						AGGGGCAAGGTATTTGCACTG	0.393000													30	54					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2110816	2110816	+	Splice_Site	SNP	T	T	C	rs137854173		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2110816T>C	ENST00000219476.3	+	11	1749		c.e11+2		TSC2_ENST00000353929.4_Splice_Site|TSC2_ENST00000350773.4_Splice_Site|TSC2_ENST00000568454.1_Splice_Site|TSC2_ENST00000439673.2_Splice_Site|TSC2_ENST00000382538.6_Splice_Site|TSC2_ENST00000401874.2_Splice_Site	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2						cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				CAGCTCCAGGTGGGGTGGGGG	0.627000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				9	15					0	0	1	0	0
WDR25	79446	broad.mit.edu	37	14	100950458	100950458	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:100950458C>T	ENST00000335290.6	+	4	1324	c.1098C>T	c.(1096-1098)ggC>ggT	p.G366G	WDR25_ENST00000542471.2_Silent_p.G109G|WDR25_ENST00000554998.1_Silent_p.G366G|WDR25_ENST00000402312.3_Silent_p.G366G	NM_024515.4	NP_078791.3	Q64LD2	WDR25_HUMAN	WD repeat domain 25	366										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				TAAGGACTGGCAAGGTAATAG	0.408000													53	84					0	0	1	0	0
ZNF337	26152	broad.mit.edu	37	20	25657081	25657081	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:25657081C>T	ENST00000376436.1	-	4	1382	c.843G>A	c.(841-843)gtG>gtA	p.V281V	RP4-694B14.5_ENST00000414393.1_RNA|RP4-694B14.5_ENST00000439498.1_RNA|ZNF337_ENST00000252979.5_Silent_p.V281V|ZNF337_ENST00000538750.1_Silent_p.V249V|RP4-694B14.5_ENST00000455791.1_RNA					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TTCTCTCATGCACAGTGAGGT	0.498000													42	85					0	0	1	0	0
BRPF1	7862	broad.mit.edu	37	3	9776113	9776113	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9776113C>T	ENST00000383829.2	+	2	693	c.289C>T	c.(289-291)Cgc>Tgc	p.R97C	BRPF1_ENST00000457855.1_Missense_Mutation_p.R97C|BRPF1_ENST00000433861.2_Missense_Mutation_p.R97C|BRPF1_ENST00000302054.3_Missense_Mutation_p.R97C|BRPF1_ENST00000424362.1_Missense_Mutation_p.R97C	NM_001003694.1	NP_001003694.1	P55201	BRPF1_HUMAN	bromodomain and PHD finger containing, 1	97	Interaction with MYST3 and MYST4.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	49	Medulloblastoma(99;0.227)					ACAGGCCCAGCGCATGGTGGA	0.627000													16	30					0	0	1	0	0
EYA2	2139	broad.mit.edu	37	20	45801489	45801489	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:45801489A>G	ENST00000327619.5	+	12	1546	c.1172A>G	c.(1171-1173)tAc>tGc	p.Y391C	EYA2_ENST00000317304.6_Missense_Mutation_p.Y361C|EYA2_ENST00000357410.3_Missense_Mutation_p.Y391C	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	391					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				AAGGAGATGTACAATACCTAC	0.602000													14	21					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73055702	73055702	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:73055702G>A	ENST00000335350.6	+	14	2726	c.2310G>A	c.(2308-2310)ctG>ctA	p.L770L	UNC5B_ENST00000373192.4_Silent_p.L759L	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	770					apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						GGAGCAAGCTGCTGGCCAAAT	0.627000													12	18					0	0	1	0	0
ATMIN	23300	broad.mit.edu	37	16	81078146	81078146	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:81078146C>T	ENST00000566488.1	+	3	2538	c.1575C>T	c.(1573-1575)acC>acT	p.T525T	ATMIN_ENST00000299575.4_Silent_p.T681T|ATMIN_ENST00000564241.1_Silent_p.T525T|ATMIN_ENST00000539819.1_3'UTR			O43313	ATMIN_HUMAN	ATM interactor	681				Y -> H (in Ref. 2; CAH18291).	response to DNA damage stimulus	nucleus	zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	20						TCGCAGATACCTCTGCTCAGT	0.448000													30	65					0	0	1	0	0
CDC25A	993	broad.mit.edu	37	3	48219456	48219456	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48219456C>T	ENST00000302506.3	-	7	980	c.572G>A	c.(571-573)aGc>aAc	p.S191N	CDC25A_ENST00000351231.3_Missense_Mutation_p.S151N	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	191					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		TGGTTCACTGCTATCTCTTTC	0.413000													4	126					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160050801	160050801	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:160050801G>A	ENST00000263635.6	+	17	3013	c.2776G>A	c.(2776-2778)Gtg>Atg	p.V926M	TANC1_ENST00000454300.1_Missense_Mutation_p.V820M	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	926						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						AGGGGCCAACGTGAACTACAG	0.502000													8	53					0	0	1	0	0
FZD5	7855	broad.mit.edu	37	2	208631911	208631911	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:208631911C>T	ENST00000295417.3	-	2	2106	c.1553G>A	c.(1552-1554)gGc>gAc	p.G518D		NM_003468.3	NP_003459.2	Q13467	FZD5_HUMAN	frizzled family receptor 5	518					angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			NS(1)|kidney(1)|lung(1)|ovary(2)|prostate(1)|skin(1)	7				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		GATCCAGACGCCCGACGTGAT	0.706000													4	6					0	0	1	0	0
ABHD2	11057	broad.mit.edu	37	15	89698746	89698746	+	Silent	SNP	G	G	A	rs139707395		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:89698746G>A	ENST00000352732.5	+	5	1039	c.519G>A	c.(517-519)tcG>tcA	p.S173S	ABHD2_ENST00000565973.1_Silent_p.S173S|ABHD2_ENST00000355100.3_Silent_p.S173S	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	173						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					AATTGACCTCGCCACGCATGT	0.488000													43	44					0	0	1	0	0
ESRRG	2104	broad.mit.edu	37	1	216850735	216850735	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:216850735C>T	ENST00000391890.3	-	4	603	c.86G>A	c.(85-87)aGc>aAc	p.S29N	ESRRG_ENST00000366940.2_Missense_Mutation_p.S29N|ESRRG_ENST00000487276.1_Missense_Mutation_p.S29N|ESRRG_ENST00000408911.3_Missense_Mutation_p.S52N|ESRRG_ENST00000359162.2_Missense_Mutation_p.S29N|ESRRG_ENST00000463665.1_Missense_Mutation_p.S29N|ESRRG_ENST00000493748.1_Missense_Mutation_p.S29N|ESRRG_ENST00000361395.2_Missense_Mutation_p.S29N|ESRRG_ENST00000360012.3_Missense_Mutation_p.S29N|ESRRG_ENST00000366938.2_Missense_Mutation_p.S29N|ESRRG_ENST00000366937.1_Missense_Mutation_p.S57N|ESRRG_ENST00000361525.3_Missense_Mutation_p.S29N|ESRRG_ENST00000493603.1_Missense_Mutation_p.S29N	NM_001243515.1|NM_001243519.1	NP_001230444.1|NP_001230448.1	P62508	ERR3_HUMAN	estrogen-related receptor gamma	52					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(29)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	GTGGTTGACGCTGTCCGTCAG	0.542000													10	25					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152686088	152686088	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152686088C>T	ENST00000367255.5	-	63	10640	c.10039G>A	c.(10039-10041)Gtc>Atc	p.V3347I	SYNE1_ENST00000448038.1_Missense_Mutation_p.V3354I|SYNE1_ENST00000341594.5_Missense_Mutation_p.V3386I|SYNE1_ENST00000423061.1_Missense_Mutation_p.V3354I|SYNE1_ENST00000265368.4_Missense_Mutation_p.V3347I	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3347					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCTGAAGGACAGATTCTCCC	0.433000										HNSCC(10;0.0054)			30	51					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158618332	158618332	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158618332G>A	ENST00000368148.3	-	26	3861	c.3681C>T	c.(3679-3681)ggC>ggT	p.G1227G	SPTA1_ENST00000368147.3_Silent_p.G1227G	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1227					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CCCTTTCAAAGCCCTCATGCC	0.507000													21	31					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157522284	157522284	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:157522284G>A	ENST00000346085.5	+	18	4557	c.4556G>A	c.(4555-4557)cGt>cAt	p.R1519H	ARID1B_ENST00000367148.1_Missense_Mutation_p.R1559H|ARID1B_ENST00000350026.5_Missense_Mutation_p.R1506H|ARID1B_ENST00000275248.4_Missense_Mutation_p.R1501H	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1506	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GTCAGCCAGCGTCAGCCTTAT	0.582000													24	25					0	0	1	0	0
KLHL26	55295	broad.mit.edu	37	19	18779107	18779107	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18779107G>A	ENST00000300976.4	+	3	990	c.900G>A	c.(898-900)ccG>ccA	p.P300P	KLHL26_ENST00000599006.1_Intron	NM_018316.1	NP_060786.1	Q53HC5	KLH26_HUMAN	kelch-like family member 26	300										breast(1)|central_nervous_system(1)|kidney(1)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						TGCAGTCTCCGCGCACCGCCG	0.662000													16	14					0	0	1	0	0
ITGA3	3675	broad.mit.edu	37	17	48154745	48154745	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48154745C>T	ENST00000320031.8	+	16	2403	c.2073C>T	c.(2071-2073)ccC>ccT	p.P691P	ITGA3_ENST00000007722.7_Silent_p.P691P	NM_002204.2|NM_005501.2	NP_002195.1|NP_005492.1	P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	691					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						TTCCTCAGCCCGGGGCCTGCC	0.592000													19	26					0	0	1	0	0
GGCX	2677	broad.mit.edu	37	2	85777082	85777082	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:85777082G>A	ENST00000233838.3	-	15	2332	c.2252C>T	c.(2251-2253)cCt>cTt	p.P751L	GGCX_ENST00000430215.3_Missense_Mutation_p.P694L	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase	751					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	GACAGGATCAGGATTTGACTC	0.468000													6	24					0	0	1	0	0
PCED1A	64773	broad.mit.edu	37	20	2819013	2819013	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:2819013G>A	ENST00000360652.2	-	6	1208	c.706C>T	c.(706-708)Cgg>Tgg	p.R236W	PCED1A_ENST00000356872.3_Missense_Mutation_p.R185W	NM_022760.3	NP_073597.2			PC-esterase domain containing 1A																		ACTGCATGCCGGAAGTGAAAG	0.607000													19	25					0	0	1	0	0
LMNA	4000	broad.mit.edu	37	1	156106169	156106169	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156106169C>T	ENST00000368300.4	+	7	1534	c.1322C>T	c.(1321-1323)gCc>gTc	p.A441V	LMNA_ENST00000392353.3_Missense_Mutation_p.A360V|LMNA_ENST00000368297.1_Missense_Mutation_p.A360V|LMNA_ENST00000368299.3_Missense_Mutation_p.A441V|LMNA_ENST00000448611.2_Missense_Mutation_p.A329V|LMNA_ENST00000496738.1_3'UTR|LMNA_ENST00000361308.4_Missense_Mutation_p.A441V|LMNA_ENST00000368301.2_Missense_Mutation_p.A441V|LMNA_ENST00000347559.2_Missense_Mutation_p.A441V|LMNA_ENST00000473598.2_Missense_Mutation_p.A342V	NM_170707.3	NP_733821.1	P02545	LMNA_HUMAN	lamin A/C	441	Tail.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity			NS(1)|endometrium(1)|kidney(1)|lung(3)|ovary(4)	10	Hepatocellular(266;0.158)					GGGCGCGTGGCCGTGGAGGAG	0.612000									Werner syndrome;Hutchinson-Gilford Progeria Syndrome				5	6					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113379554	113379554	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:113379554G>A	ENST00000228928.7	+	2	536	c.357G>A	c.(355-357)acG>acA	p.T119T	OAS3_ENST00000546638.1_Intron|OAS3_ENST00000548514.1_Silent_p.T119T|RP1-71H24.1_ENST00000552784.1_RNA|OAS3_ENST00000551007.1_Silent_p.T119T	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	119	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						TGAGACTCACGTTTCCTGAGC	0.602000													35	35					0	0	1	0	0
RBMXL1	494115	broad.mit.edu	37	1	89449362	89449362	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:89449362C>T	ENST00000399794.2	-	3	863	c.148G>A	c.(148-150)Gga>Aga	p.G50R	CCBL2_ENST00000370491.3_Intron|RBMXL1_ENST00000413769.1_5'UTR|CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000260508.4_Intron|RBMXL1_ENST00000321792.5_Missense_Mutation_p.G50R	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	50	RRM.						nucleotide binding|RNA binding										AAAGCAAATCCTCTTGATTTG	0.408000											OREG0013593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	63	185					0	0	1	0	0
TSPAN14	81619	broad.mit.edu	37	10	82264514	82264514	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:82264514C>T	ENST00000429989.2	+	3	335	c.112C>T	c.(112-114)Ctg>Ttg	p.L38L	TSPAN14_ENST00000372158.1_Silent_p.L38L|TSPAN14_ENST00000372164.3_Intron|TSPAN14_ENST00000481124.1_Intron|TSPAN14_ENST00000341863.6_Silent_p.L38L|TSPAN14_ENST00000372156.1_Silent_p.L38L	NM_030927.2	NP_112189.2	Q8NG11	TSN14_HUMAN	tetraspanin 14	38						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7			Colorectal(32;0.229)			TGGAGTCGGGCTGTGGGCATG	0.517000													17	47					0	0	1	0	0
FAM186B	84070	broad.mit.edu	37	12	49993361	49993361	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49993361G>T	ENST00000544141.1	-	4	2391	c.1792C>A	c.(1792-1794)Ctg>Atg	p.L598M	FAM186B_ENST00000257894.2_Missense_Mutation_p.L688M|FAM186B_ENST00000551047.1_Intron			Q8IYM0	F186B_HUMAN	family with sequence similarity 186, member B	688						protein complex				breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TTGCTGCGCAGGTAGTGGGGC	0.552000													10	36					7.48243e-07	7.8103e-07	1	1	0
CADM1	23705	broad.mit.edu	37	11	115109305	115109305	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:115109305G>A	ENST00000542447.2	-	3	467	c.339C>T	c.(337-339)aaC>aaT	p.N113N	CADM1_ENST00000537058.1_Silent_p.N113N|CADM1_ENST00000452722.2_Silent_p.N113N|CADM1_ENST00000537140.1_5'UTR|CADM1_ENST00000536727.1_Silent_p.N113N|CADM1_ENST00000331581.6_Silent_p.N113N	NM_001098517.1	NP_001091987.1	Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	113	Ig-like V-type.				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		AAATTGAGACGTTTGTCAATG	0.418000													27	43					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39927670	39927670	+	Silent	SNP	G	G	A	rs142801936	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:39927670G>A	ENST00000564288.1	+	93	22416	c.21639G>A	c.(21637-21639)gcG>gcA	p.A7213A	MACF1_ENST00000567887.1_Silent_p.A7250A|MACF1_ENST00000539005.1_Silent_p.A5024A|MACF1_ENST00000372915.3_Silent_p.A7112A|MACF1_ENST00000361689.2_Silent_p.A5154A|MACF1_ENST00000317713.7_Silent_p.A5154A|MACF1_ENST00000289893.4_Silent_p.A5656A|MACF1_ENST00000545844.1_Silent_p.A5154A			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	7112	C-terminal tail (By similarity).				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACAAGGATGCGTATCGACCAA	0.398000													43	49					0	0	1	0	0
TNIP2	79155	broad.mit.edu	37	4	2749522	2749522	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2749522G>T	ENST00000510267.1	-	2	533	c.106C>A	c.(106-108)Ctg>Atg	p.L36M	TNIP2_ENST00000315423.7_Missense_Mutation_p.L143M|TNIP2_ENST00000503235.1_Missense_Mutation_p.L143M	NM_001161527.1	NP_001154999.1	Q8NFZ5	TNIP2_HUMAN	TNFAIP3 interacting protein 2	143						cytosol	protein binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(6)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GAGCGGCACAGGACGTCACTG	0.652000													53	67					1.57914e-17	1.73871e-17	1	1	0
CALB2	794	broad.mit.edu	37	16	71423690	71423690	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:71423690C>T	ENST00000302628.4	+	11	815	c.738C>T	c.(736-738)agC>agT	p.S246S	CALB2_ENST00000349553.5_3'UTR	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	246	EF-hand 6.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				ACAGAAAGAGCGTCATGTCCT	0.557000													62	84					0	0	1	0	0
ZNF816	125893	broad.mit.edu	37	19	53432418	53432418	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53432418G>A	ENST00000549216.1	-	2	303	c.233C>T	c.(232-234)gCt>gTt	p.A78V	ZNF816_ENST00000434371.2_Missense_Mutation_p.A147V|ZNF321P_ENST00000391777.3_Missense_Mutation_p.A147V|ZNF816-ZNF321P_ENST00000313956.4_RNA	NM_001202473.1	NP_001189402.1	Q0VGE8	ZN816_HUMAN	zinc finger protein 816	147	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(10)|lung(9)|stomach(1)|urinary_tract(2)	27						CTTGTTTCCAGCATGCCTTTG	0.433000													5	218					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168110575	168110575	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:168110575C>T	ENST00000409195.1	+	10	10678	c.10589C>T	c.(10588-10590)aCt>aTt	p.T3530I	XIRP2_ENST00000420519.1_Missense_Mutation_p.L437F|XIRP2_ENST00000409728.1_Missense_Mutation_p.L437F|XIRP2_ENST00000409756.2_Missense_Mutation_p.L404F|XIRP2_ENST00000295237.9_Missense_Mutation_p.T3530I|XIRP2_ENST00000409605.1_Missense_Mutation_p.L182F|XIRP2_ENST00000409273.1_Missense_Mutation_p.T3308I|XIRP2_ENST00000409043.1_Missense_Mutation_p.L404F	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3355					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AATATGTATACTTTGTCAAAA	0.353000													26	29					0	0	1	0	0
TMEM40	55287	broad.mit.edu	37	3	12791290	12791290	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:12791290A>G	ENST00000314124.7	-	2	398	c.42T>C	c.(40-42)agT>agC	p.S14S	TMEM40_ENST00000435575.1_Silent_p.S14S|TMEM40_ENST00000435218.2_Silent_p.S14S|TMEM40_ENST00000264728.8_Silent_p.S14S|TMEM40_ENST00000431022.2_Silent_p.S30S	NM_018306.2	NP_060776.2	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	14						integral to membrane				breast(1)|large_intestine(3)|lung(5)|urinary_tract(1)	10						TGTGGACTTGACTGTTGTCCT	0.448000													30	35					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20761115	20761115	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:20761115G>A	ENST00000400451.2	+	5	2306	c.1792G>A	c.(1792-1794)Gtg>Atg	p.V598M	ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000356671.5_Missense_Mutation_p.V598M|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000405993.1_Missense_Mutation_p.V566M	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	598					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			cacatactacgtgcctggcag	0.612000													8	26					0	0	1	0	0
AC006293.3	0	broad.mit.edu	37	19	55222078	55222078	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55222078C>T	ENST00000413439.1	+	0	1605																											GCTGAATTCCCCATGAGTCCT	0.602000													24	37					0	0	1	0	0
ENTPD4	9583	broad.mit.edu	37	8	23290518	23290518	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:23290518C>T	ENST00000358689.4	-	13	2007	c.1772G>A	c.(1771-1773)cGc>cAc	p.R591H	ENTPD4_ENST00000521321.1_Intron|ENTPD4_ENST00000417069.2_Missense_Mutation_p.R583H|ENTPD4_ENST00000356206.6_Intron	NM_001128930.2|NM_004901.4	NP_001122402.1|NP_004892.1	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	591					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		CCGGGGAGTGCGCCTGTGGAT	0.647000													8	8					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649356	75649356	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:75649356C>T	ENST00000361470.2	+	1	1311	c.1033C>T	c.(1033-1035)Ccg>Tcg	p.P345S		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	345	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						CACCTCCGTGCCGCCCACTCC	0.682000													7	1					0	0	1	0	0
GFI1B	8328	broad.mit.edu	37	9	135863817	135863817	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:135863817C>A	ENST00000339463.3	+	8	1291	c.472C>A	c.(472-474)Cca>Aca	p.P158T	GFI1B_ENST00000372124.1_Missense_Mutation_p.P158T|GFI1B_ENST00000372123.1_Missense_Mutation_p.P158T|GFI1B_ENST00000534944.1_Missense_Mutation_p.P158T|GFI1B_ENST00000372122.1_Missense_Mutation_p.P158T|GFI1B_ENST00000450530.1_Missense_Mutation_p.P158T			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	158	Interaction with ARIH2.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		CCGCTACTCCCCAGGCATGGA	0.637000													8	17					7.48243e-07	7.8103e-07	1	1	0
CTAGE1	64693	broad.mit.edu	37	18	19997347	19997347	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:19997347A>G	ENST00000391403.2	-	1	531	c.428T>C	c.(427-429)aTa>aCa	p.I143T		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	143						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TAGCGACTGTATCCTTTTGGA	0.363000													54	79					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34078152	34078152	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:34078152C>T	ENST00000389232.4	+	66	9628	c.9558C>T	c.(9556-9558)atC>atT	p.I3186I	RYR3_ENST00000415757.3_Silent_p.I3186I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3186					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACCTGGGCATCGATGAGGCCT	0.542000													45	57					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187531072	187531072	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:187531072G>A	ENST00000441802.2	-	15	10160	c.9951C>T	c.(9949-9951)gaC>gaT	p.D3317D		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3317	Cadherin 30.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CAGTGGCAACGTCGCTCAGTG	0.468000										HNSCC(5;0.00058)			15	16					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62289163	62289163	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62289163G>A	ENST00000378024.4	-	5	13000	c.12726C>T	c.(12724-12726)ggC>ggT	p.G4242G	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4242					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGAATTTAGGGCCCTTTAGTT	0.488000													100	145					0	0	1	0	0
HIPK1	204851	broad.mit.edu	37	1	114512767	114512767	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:114512767G>A	ENST00000369558.1	+	14	3193	c.2961G>A	c.(2959-2961)gtG>gtA	p.V987V	HIPK1_ENST00000406344.1_Silent_p.V593V|HIPK1_ENST00000369555.2_Silent_p.V942V|HIPK1_ENST00000340480.4_Silent_p.V613V|HIPK1_ENST00000369559.4_Silent_p.V987V|HIPK1_ENST00000369553.1_Silent_p.V593V|HIPK1_ENST00000426820.2_Silent_p.V987V|HIPK1_ENST00000369561.4_Silent_p.V953V|HIPK1_ENST00000369554.2_Silent_p.V942V			Q86Z02	HIPK1_HUMAN	homeodomain interacting protein kinase 1	987	Interaction with TP53.|Required for localization to nuclear speckles (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTATCATTGTGCCTCCACTGA	0.527000													21	79					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84694864	84694864	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:84694864C>T	ENST00000284136.6	-	6	637	c.594G>A	c.(592-594)gaG>gaA	p.E198E	SEMA3D_ENST00000444867.1_Silent_p.E198E	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	198	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						AGTAGAGGTACTCATCTGAGA	0.413000													14	30					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179985037	179985037	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:179985037G>C	ENST00000367607.3	+	11	2524	c.2106G>C	c.(2104-2106)caG>caC	p.Q702H		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	702						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						ACAAAGTACAGGAACGTCCCC	0.418000													7	16					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61687978	61687978	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:61687978C>T	ENST00000577390.1	-	12	2888	c.1934G>A	c.(1933-1935)cGg>cAg	p.R645Q	CDH8_ENST00000299345.6_Missense_Mutation_p.R645Q|CDH8_ENST00000577730.1_Missense_Mutation_p.R645Q	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	645					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTTATGCCGCCGTAGAGTTAC	0.383000													36	49					0	0	1	0	0
GSDMA	284110	broad.mit.edu	37	17	38133270	38133270	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38133270G>A	ENST00000301659.4	+	12	1415	c.1297G>A	c.(1297-1299)Gca>Aca	p.A433T		NM_178171.4	NP_835465.2	Q96QA5	GSDMA_HUMAN	gasdermin A	433					apoptosis|induction of apoptosis	perinuclear region of cytoplasm				NS(1)|endometrium(2)|large_intestine(3)|lung(1)	7						TGCTCTTTATGCAGGCCTCTC	0.567000													21	31					0	0	1	0	0
MYD88	4615	broad.mit.edu	37	3	38182003	38182003	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38182003C>T	ENST00000417037.2	+	3	811	c.627C>T	c.(625-627)cgC>cgT	p.R209R	MYD88_ENST00000495303.1_Intron|MYD88_ENST00000443433.2_Intron|MYD88_ENST00000481122.1_3'UTR|MYD88_ENST00000396334.3_Silent_p.R209R|MYD88_ENST00000424893.1_Silent_p.R164R	NM_001172567.1	NP_001166038.1	Q99836	MYD88_HUMAN	myeloid differentiation primary response 88	196	TIR.				3'-UTR-mediated mRNA stabilization|anti-apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|regulation of inflammatory response|response to interleukin-1|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|intrinsic to membrane|plasma membrane	death receptor binding|TIR domain binding|transmembrane receptor activity	p.R209R(1)		breast(1)|haematopoietic_and_lymphoid_tissue(226)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	237				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGTCTGACCGCGATGTCCTGC	0.542000			Mis		ABC-DLBCL								33	42					0	0	1	0	0
DERL1	79139	broad.mit.edu	37	8	124031544	124031544	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:124031544C>T	ENST00000259512.4	-	7	808	c.506_splice	c.e7-1	p.V170_splice	DERL1_ENST00000419562.2_Splice_Site_p.V70_splice|RP11-557C18.3_ENST00000521258.1_RNA|DERL1_ENST00000519018.1_Splice_Site_p.V70_splice|DERL1_ENST00000523036.1_Splice_Site_p.V70_splice|DERL1_ENST00000405944.3_Intron	NM_001134671.1|NM_024295.4	NP_001128143.1|NP_077271.1	Q9BUN8	DERL1_HUMAN	derlin 1	170					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|intracellular transport of viral proteins in host cell|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	MHC class I protein binding|receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	8	Lung NSC(37;1.06e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			TCATTGATTACCCTGCAAAGA	0.388000													10	16					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907625	77907625	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:77907625G>A	ENST00000355300.6	-	2	798	c.624C>T	c.(622-624)acC>acT	p.T208T	LINGO1_ENST00000561030.1_Silent_p.T202T	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	208					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						ACAGCGCCTCGGTGGGGATGG	0.607000													43	41					0	0	1	0	0
TDG	6996	broad.mit.edu	37	12	104377098	104377098	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104377098A>C	ENST00000392872.3	+	7	957	c.723A>C	c.(721-723)gaA>gaC	p.E241D	TDG_ENST00000544861.1_Missense_Mutation_p.E98D|TDG_ENST00000542036.1_Missense_Mutation_p.E37D|TDG_ENST00000266775.9_Missense_Mutation_p.E237D	NM_003211.4	NP_003202.3	Q13569	TDG_HUMAN	thymine-DNA glycosylase	241					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			large_intestine(2)|lung(14)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(302;0.00114)		TTAGTAAAGAAGTTTTTGGAG	0.279000								Base excision repair (BER), DNA glycosylases					38	54					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2307027	2307027	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2307027C>T	ENST00000290974.2	-	8	1379	c.1040G>A	c.(1039-1041)cGc>cAc	p.R347H	ZFYVE28_ENST00000511071.1_Missense_Mutation_p.R317H|RP11-478C1.7_ENST00000510632.1_RNA|ZFYVE28_ENST00000515312.1_Missense_Mutation_p.R277H	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	347					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GTGGACCATGCGGCTGAGCTG	0.662000													14	20					0	0	1	0	0
ZDHHC14	79683	broad.mit.edu	37	6	158093781	158093781	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:158093781G>A	ENST00000359775.5	+	9	1983	c.1094G>A	c.(1093-1095)aGc>aAc	p.S365N	ZDHHC14_ENST00000414563.2_Intron|ZDHHC14_ENST00000341375.8_3'UTR			Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14	365						integral to membrane	acyltransferase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	17		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		TGCATTCAGAGCACCAAATTC	0.662000													10	15					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1585167	1585167	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1585167G>A	ENST00000572621.1	-	4	865	c.600C>T	c.(598-600)gaC>gaT	p.D200D	PRPF8_ENST00000304992.6_Silent_p.D200D			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	200						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		ACACAGGGGCGTCCTCCTCAG	0.542000													25	52					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241713664	241713664	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:241713664T>C	ENST00000498729.2	-	12	1219	c.973A>G	c.(973-975)Aca>Gca	p.T325A	KIF1A_ENST00000320389.7_Missense_Mutation_p.T325A	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	325	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ACCATAGCTGTCCTTGAGTTA	0.577000													12	11					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67327470	67327470	+	Missense_Mutation	SNP	C	C	A	rs73592842	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67327470C>A	ENST00000304372.5	-	12	2250	c.2195G>T	c.(2194-2196)aGc>aTc	p.S732I		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	732						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CCTCTGCTTGCTCCAGTCCTT	0.542000													26	66					1.2476e-16	1.37101e-16	1	1	0
PIP	5304	broad.mit.edu	37	7	142836256	142836256	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142836256C>T	ENST00000291009.3	+	3	330	c.290C>T	c.(289-291)aCc>aTc	p.T97I		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	97						extracellular region	actin binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		AATCCAAAAACCTTCTACTGG	0.438000													22	86					0	0	1	0	0
ZNF789	285989	broad.mit.edu	37	7	99084663	99084663	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99084663G>T	ENST00000331410.5	+	5	1100	c.830G>T	c.(829-831)aGg>aTg	p.R277M	ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron	NM_213603.2	NP_998768.2	Q5FWF6	ZN789_HUMAN	zinc finger protein 789	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GAACATAAGAGGATTCACACC	0.398000													24	27					6.44725e-10	6.8705e-10	1	1	0
MMP17	4326	broad.mit.edu	37	12	132334397	132334397	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:132334397C>T	ENST00000360564.1	+	9	1357	c.1255C>T	c.(1255-1257)Cgc>Tgc	p.R419C	MMP17_ENST00000535291.1_Missense_Mutation_p.R335C|MMP17_ENST00000535004.1_Intron	NM_016155.4	NP_057239.4	Q9ULZ9	MMP17_HUMAN	matrix metallopeptidase 17 (membrane-inserted)	419	Hemopexin-like 2.				proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)	5	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		AGGATACCCGCGCCCCGTCTC	0.612000													4	75					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180057555	180057555	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:180057555C>A	ENST00000261937.6	-	3	478	c.400_splice	c.e3+1	p.D134_splice	FLT4_ENST00000502649.1_Splice_Site_p.D134_splice|FLT4_ENST00000393347.3_Splice_Site_p.D134_splice|FLT4_ENST00000424276.2_5'UTR	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	134					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CAAGTCTCACCTCTCACGAAC	0.657000													13	8					2.48551e-13	2.69865e-13	1	1	0
RMND1	55005	broad.mit.edu	37	6	151744681	151744681	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:151744681A>G	ENST00000367303.4	-	7	1038	c.916T>C	c.(916-918)Tcc>Ccc	p.S306P	RMND1_ENST00000336451.3_Missense_Mutation_p.S95P	NM_017909.2	NP_060379.2	Q9NWS8	RMND1_HUMAN	required for meiotic nuclear division 1 homolog (S. cerevisiae)	306										central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.146)	OV - Ovarian serous cystadenocarcinoma(155;6.8e-11)		AGAGCATTGGAGAAAGCAAAC	0.398000													33	44					0	0	1	0	0
FAM5B	0	broad.mit.edu	37	1	177250451	177250451	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:177250451G>A	ENST00000361539.4	+	8	2451	c.2139G>A	c.(2137-2139)caG>caA	p.Q713Q	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		713						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						AAGGTTCCCAGGACTCTGCAC	0.532000													25	71					0	0	1	0	0
NDUFAF6	137682	broad.mit.edu	37	8	96059229	96059229	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:96059229G>T	ENST00000396113.1	+	12	1362	c.312G>T	c.(310-312)aaG>aaT	p.K104N	NDUFAF6_ENST00000396111.2_Missense_Mutation_p.K104N|NDUFAF6_ENST00000396124.4_Missense_Mutation_p.K196N|NDUFAF6_ENST00000286687.4_Missense_Mutation_p.K44N|NDUFAF6_ENST00000542894.1_Missense_Mutation_p.K144N			Q330K2	CH038_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6	196					biosynthetic process	mitochondrion	transferase activity										TAGGTATAAAGGATCTTCATG	0.368000													15	24					1.3612e-06	1.41782e-06	1	1	0
USP19	10869	broad.mit.edu	37	3	49148431	49148431	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49148431C>T	ENST00000453664.1	-	23	3779	c.3461G>A	c.(3460-3462)tGc>tAc	p.C1154Y	USP19_ENST00000434032.2_Missense_Mutation_p.C1164Y|USP19_ENST00000417901.1_Missense_Mutation_p.C1166Y|USP19_ENST00000398892.3_Missense_Mutation_p.C1103Y|USP19_ENST00000398888.2_Missense_Mutation_p.C1063Y|USP19_ENST00000398896.1_Missense_Mutation_p.C871Y|USP19_ENST00000398898.2_Missense_Mutation_p.C1103Y	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	1063					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GAGGTTGAGGCACTGGTCCAG	0.612000													13	35					0	0	1	0	0
DDX39B	7919	broad.mit.edu	37	6	31508224	31508224	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31508224G>C	ENST00000417556.2	-	2	716	c.86C>G	c.(85-87)gCc>gGc	p.A29G	DDX39B_ENST00000396172.1_Missense_Mutation_p.A29G|DDX39B_ENST00000453105.2_Missense_Mutation_p.P25A|DDX39B_ENST00000376177.2_Missense_Mutation_p.A29G|DDX39B_ENST00000458640.1_Missense_Mutation_p.A29G|ATP6V1G2-DDX39B_ENST00000376185.1_3'UTR|DDX39B_ENST00000415382.2_Missense_Mutation_p.P25A|DDX39B_ENST00000449074.2_Missense_Mutation_p.A29G			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	29					intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						CTTGGCAGGGGCCTCAGCCCC	0.572000													19	50					0	0	1	0	0
TAF4	6874	broad.mit.edu	37	20	60581673	60581673	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:60581673C>T	ENST00000252996.3	-	7	2115	c.2116G>A	c.(2116-2118)Gcc>Acc	p.A706T	TAF4_ENST00000488539.1_5'UTR	NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	706					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			GTCTTCCCGGCCGTGCGCTGG	0.721000													5	9					0	0	1	0	0
CECR6	27439	broad.mit.edu	37	22	17600946	17600946	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:17600946G>A	ENST00000331437.3	-	1	1197	c.1072C>T	c.(1072-1074)Ctg>Ttg	p.L358L	CECR6_ENST00000399875.1_Silent_p.L3L	NM_031890.3	NP_114096.1	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	358										haematopoietic_and_lymphoid_tissue(1)	1		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		GGCACCGACAGCGCCATGGTG	0.697000													15	45					0	0	1	0	0
ZNF587	84914	broad.mit.edu	37	19	58371214	58371214	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58371214C>T	ENST00000339656.5	+	3	1616	c.1434C>T	c.(1432-1434)agC>agT	p.S478S	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF587_ENST00000423137.1_Silent_p.S477S|ZNF814_ENST00000595295.1_Intron|ZNF587_ENST00000419854.1_Silent_p.S435S	NM_001204817.1|NM_032828.3	NP_001191746.1|NP_116217.1	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S478R(1)		central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		ATAAGCACAGCGTGACTATAC	0.423000													54	92					0	0	1	0	0
SLC18A2	6571	broad.mit.edu	37	10	119013558	119013558	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:119013558G>T	ENST00000298472.5	+	5	666		c.e5-1		SLC18A2_ENST00000497497.1_Splice_Site	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2						neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TCTCTCGGCAGTGTTTGCCTT	0.592000													53	69					1.3268e-25	1.48173e-25	1	1	0
SPAG17	200162	broad.mit.edu	37	1	118635826	118635826	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:118635826G>A	ENST00000336338.5	-	8	1191	c.1126C>T	c.(1126-1128)Caa>Taa	p.Q376*		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	376						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTAACCACTTGTGGAACATTA	0.398000													34	41					0	0	1	0	0
TLE3	7090	broad.mit.edu	37	15	70347431	70347431	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:70347431C>T	ENST00000558939.1	-	15	2921	c.1544G>A	c.(1543-1545)aGc>aAc	p.S515N	TLE3_ENST00000442299.2_Missense_Mutation_p.S507N|TLE3_ENST00000560939.1_Missense_Mutation_p.S517N|TLE3_ENST00000559191.1_Missense_Mutation_p.S96N|TLE3_ENST00000559929.1_Missense_Mutation_p.S525N|TLE3_ENST00000560589.1_Missense_Mutation_p.S459N|TLE3_ENST00000317509.8_Missense_Mutation_p.S503N|TLE3_ENST00000558201.1_Missense_Mutation_p.S521N|TLE3_ENST00000557997.1_Missense_Mutation_p.S507N|TLE3_ENST00000539550.1_Missense_Mutation_p.S442N|TLE3_ENST00000557907.1_Missense_Mutation_p.S507N|TLE3_ENST00000558379.1_Missense_Mutation_p.S510N|TLE3_ENST00000440567.3_Missense_Mutation_p.S505N|TLE3_ENST00000559048.1_Missense_Mutation_p.S515N|TLE3_ENST00000451782.2_Missense_Mutation_p.S512N			Q04726	TLE3_HUMAN	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	515					organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GCCTGGCTGGCTGATGTCCCA	0.647000													7	14					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	30927538	30927538	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:30927538C>T	ENST00000399914.1	-	15	2918	c.2397G>A	c.(2395-2397)tgG>tgA	p.W799*	GRIK1_ENST00000389125.3_Nonsense_Mutation_p.W799*|GRIK1_ENST00000399913.1_Nonsense_Mutation_p.W814*|GRIK1_ENST00000535441.1_Nonsense_Mutation_p.W816*|GRIK1_ENST00000327783.4_Nonsense_Mutation_p.W814*|GRIK1_ENST00000399909.1_Nonsense_Mutation_p.W799*|GRIK1_ENST00000389124.2_Nonsense_Mutation_p.W814*|GRIK1_ENST00000309434.7_Nonsense_Mutation_p.W816*|GRIK1_ENST00000399907.1_Nonsense_Mutation_p.W814*			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	814					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CATTCCCACGCCACCACTTCT	0.483000													30	19					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4967865	4967865	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:4967865G>T	ENST00000380373.2	-	1	491	c.466C>A	c.(466-468)Ctc>Atc	p.L156I	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGAACCAGGAGCATGCTCTTA	0.423000													92	94					4.76065e-52	5.35449e-52	1	1	0
USH2A	7399	broad.mit.edu	37	1	216371664	216371664	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:216371664T>C	ENST00000366943.2	-	18	4460	c.4074A>G	c.(4072-4074)ggA>ggG	p.G1358G	USH2A_ENST00000366942.3_Silent_p.G1358G|RP5-1099E6.3_ENST00000420867.1_RNA|USH2A_ENST00000307340.3_Silent_p.G1358G			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1358					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TACCTGATTCTCCCGTTCTTT	0.388000										HNSCC(13;0.011)			36	56					0	0	1	0	0
IGHJ5	0	broad.mit.edu	37	14	106330039	106330039	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:106330039C>T	ENST00000488476.1	-	0	33																											GAGACGGTGACCAGGGTTCCC	0.607000													7	9					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	5965426	5965426	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:5965426C>T	ENST00000378156.4	-	15	2146	c.1881G>A	c.(1879-1881)acG>acA	p.T627T	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	627			T -> M (in SLSN4).		actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGGTTAAACGTCACAGGTT	0.493000													4	138					0	0	1	0	0
WDR5	11091	broad.mit.edu	37	9	137023095	137023095	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:137023095C>T	ENST00000358625.3	+	14	1156	c.985C>T	c.(985-987)Ctg>Ttg	p.L329L	WDR5_ENST00000425041.1_Silent_p.L329L	NM_017588.2	NP_060058.1	P61964	WDR5_HUMAN	WD repeat domain 5	329					histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	9		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		AACAATTAAACTGTGGAAGAG	0.493000													25	37					0	0	1	0	0
JAG2	3714	broad.mit.edu	37	14	105615403	105615403	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105615403C>T	ENST00000331782.3	-	14	2180	c.1777G>A	c.(1777-1779)Gcg>Acg	p.A593T	JAG2_ENST00000347004.2_Missense_Mutation_p.A555T	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	593	EGF-like 10; atypical.				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CCAGGCCCCGCGTCTGACCCG	0.682000													3	5					0	0	1	0	0
IK	3550	broad.mit.edu	37	5	140032579	140032579	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140032579G>A	ENST00000417647.2	+	5	393	c.254G>A	c.(253-255)cGc>cAc	p.R85H	IK_ENST00000523672.1_3'UTR	NM_006083.3	NP_006074.2	Q13123	RED_HUMAN	IK cytokine, down-regulator of HLA II	85					cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCAAGCTACGCCAACAAGAA	0.468000													15	10					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32061205	32061205	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:32061205G>A	ENST00000438447.1	+	14	2804	c.2416G>A	c.(2416-2418)Gtt>Att	p.V806I	PDZD2_ENST00000282493.3_Missense_Mutation_p.V806I			O15018	PDZD2_HUMAN	PDZ domain containing 2	806	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						TCCAGGACCCGTTCGCCTTGT	0.537000													18	31					0	0	1	0	0
C22orf29	79680	broad.mit.edu	37	22	19838799	19838799	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19838799T>C	ENST00000405640.1	-	2	1654	c.986A>G	c.(985-987)gAg>gGg	p.E329G	GNB1L_ENST00000460402.1_Intron|GNB1L_ENST00000329517.6_Intron|C22orf29_ENST00000328554.4_Missense_Mutation_p.E329G|C22orf29_ENST00000484072.1_Intron|C22orf29_ENST00000407472.1_Missense_Mutation_p.E329G|GNB1L_ENST00000405009.1_Intron|GNB1L_ENST00000403325.1_Intron			Q7L3V2	CV029_HUMAN	chromosome 22 open reading frame 29	329										NS(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	7	Colorectal(54;0.0993)					CAAAACCTCCTCCTCTGTTTT	0.602000													3	18					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196729521	196729521	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:196729521G>A	ENST00000312428.6	-	41	6958	c.6858C>T	c.(6856-6858)atC>atT	p.I2286I		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2286					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CCACATCTGCGATTTCTCTGT	0.378000													41	59					0	0	1	0	0
PGC	5225	broad.mit.edu	37	6	41704632	41704632	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:41704632G>A	ENST00000373025.3	-	9	1187	c.1125C>T	c.(1123-1125)taC>taT	p.Y375Y		NM_002630.3	NP_002621.1	P20142	PEPC_HUMAN	progastricsin (pepsinogen C)	375					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|skin(1)	16	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			TGCCCAAGTCGTAGACGGAAT	0.612000													6	18					0	0	1	0	0
EDN3	1908	broad.mit.edu	37	20	57899383	57899383	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:57899383C>T	ENST00000395654.3	+	4	654	c.542_splice	c.e4-1	p.Q182_splice	EDN3_ENST00000371028.2_Intron|EDN3_ENST00000311585.7_Intron|EDN3_ENST00000371025.3_Intron|EDN3_ENST00000337938.2_Intron	NM_207033.1	NP_996916.1	P14138	EDN3_HUMAN	endothelin 3	196					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	19	all_lung(29;0.0115)					TTCCCCAAGACAGGTTGAAGT	0.498000													6	73					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31910873	31910873	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31910873C>T	ENST00000456570.1	+	7	953	c.898C>T	c.(898-900)Ctg>Ttg	p.L300L	C2_ENST00000452323.2_Silent_p.L239L|CFB_ENST00000477310.1_Intron|C2_ENST00000299367.5_Silent_p.L453L|C2_ENST00000469372.1_Silent_p.L207L|C2_ENST00000442278.2_Silent_p.L321L|CFB_ENST00000556679.1_Silent_p.L300L			P00751	CFAB_HUMAN	complement factor B	469	VWFA.			V -> L (in Ref. 10; AAA36225).	complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TGAACATATGCTGGGTGAGTG	0.572000													27	136					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	90036015	90036015	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:90036015A>G	ENST00000428670.3	-	3	782	c.326T>C	c.(325-327)gTc>gCc	p.V109A	ATP2B1_ENST00000261173.2_Missense_Mutation_p.V109A|ATP2B1_ENST00000359142.3_Missense_Mutation_p.V109A|ATP2B1_ENST00000348959.3_Missense_Mutation_p.V109A			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	109					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						AATTAAAGTGACATCTTGTAA	0.358000													50	162					0	0	1	0	0
FANCA	2175	broad.mit.edu	37	16	89805299	89805299	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:89805299G>A	ENST00000568369.1	-	42	4285	c.4255C>T	c.(4255-4257)Cgt>Tgt	p.R1419C	FANCA_ENST00000389301.3_Silent_p.H1417H|ZNF276_ENST00000289816.5_3'UTR			O15360	FANCA_HUMAN	Fanconi anemia, complementation group A	0					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			breast(5)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|urinary_tract(3)	47		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		CCTCTGCCACGTGTGAGAAGC	0.532000			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				6	87					0	0	1	0	0
TRNT1	51095	broad.mit.edu	37	3	3178985	3178985	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:3178985G>T	ENST00000251607.6	+	3	292	c.190G>T	c.(190-192)Gga>Tga	p.G64*	TRNT1_ENST00000280591.6_Nonsense_Mutation_p.G64*	NM_182916.2	NP_886552.2	Q96Q11	TRNT1_HUMAN	tRNA nucleotidyl transferase, CCA-adding, 1	64					protein targeting to mitochondrion|tRNA 3'-end processing	mitochondrion	ATP binding|tRNA adenylyltransferase activity|tRNA binding			breast(2)|endometrium(3)|large_intestine(4)|lung(2)|urinary_tract(1)	12				Epithelial(13;0.00226)|OV - Ovarian serous cystadenocarcinoma(96;0.00592)|all cancers(10;0.011)		AATAGCAGGAGGAGCAGTGAG	0.363000													7	14					2.7689e-08	2.91998e-08	1	1	0
SH3GLB2	56904	broad.mit.edu	37	9	131777084	131777084	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131777084C>T	ENST00000372564.3	-	4	579	c.434G>A	c.(433-435)cGc>cAc	p.R145H	SH3GLB2_ENST00000372554.4_Missense_Mutation_p.R145H|SH3GLB2_ENST00000416629.1_Missense_Mutation_p.R145H|SH3GLB2_ENST00000417224.1_Missense_Mutation_p.R145H|SH3GLB2_ENST00000372559.1_Missense_Mutation_p.R145H	NM_020145.2	NP_064530.1	Q9NR46	SHLB2_HUMAN	SH3-domain GRB2-like endophilin B2	145	BAR.				filopodium assembly|signal transduction	cytoplasm|nucleus	cytoskeletal adaptor activity|SH3 domain binding			NS(1)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)	12						CAGGAAGTTGCGCAAGGGTGT	0.572000													31	60					0	0	1	0	0
HIF1A	3091	broad.mit.edu	37	14	62207832	62207832	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:62207832A>G	ENST00000394997.1	+	12	2287	c.2022A>G	c.(2020-2022)ggA>ggG	p.G674G	HIF1A_ENST00000323441.6_Silent_p.G673G|RP11-618G20.1_ENST00000555937.1_RNA|HIF1A_ENST00000539097.1_Silent_p.G697G|HIF1A_ENST00000337138.4_Silent_p.G673G|HIF1A_ENST00000557538.1_Silent_p.G614G|HIF1A-AS2_ENST00000554254.1_lincRNA			Q16665	HIF1A_HUMAN	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	673	ID.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|endometrium(8)|kidney(6)|large_intestine(3)|lung(4)	23				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		ACAGAGCAGGAAAAGGAGTCA	0.398000													22	36					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12957581	12957581	+	Silent	SNP	C	C	T	rs138749997	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:12957581C>T	ENST00000276297.4	-	9	2674	c.2265G>A	c.(2263-2265)acG>acA	p.T755T	DLC1_ENST00000512044.2_Silent_p.T352T|DLC1_ENST00000520226.1_Silent_p.T244T|DLC1_ENST00000358919.2_Silent_p.T318T	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	755					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CAGGGCTGGGCGTGCTGACCG	0.582000													8	28					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17893965	17893965	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17893965G>A	ENST00000594202.1	+	24	2356	c.2077G>A	c.(2077-2079)Gcc>Acc	p.A693T	FCHO1_ENST00000596536.1_Missense_Mutation_p.A693T|FCHO1_ENST00000539407.1_Missense_Mutation_p.A693T|FCHO1_ENST00000252771.7_Missense_Mutation_p.A693T|FCHO1_ENST00000597512.1_Missense_Mutation_p.A700T|FCHO1_ENST00000389133.4_Missense_Mutation_p.A693T|FCHO1_ENST00000600676.1_Missense_Mutation_p.A693T|FCHO1_ENST00000596951.1_Missense_Mutation_p.A693T|FCHO1_ENST00000595033.1_Missense_Mutation_p.A643T	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	693										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CCAGCCCAACGCCGATCTGCT	0.617000													7	15					0	0	1	0	0
RSAD2	91543	broad.mit.edu	37	2	7018222	7018222	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:7018222C>A	ENST00000382040.3	+	1	427	c.291C>A	c.(289-291)tcC>tcA	p.S97S		NM_080657.4	NP_542388.2	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing 2	97					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)	20	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		CCAAAACATCCTTTGTGCTGC	0.507000													12	23					0.00010058	0.000103117	1	1	0
PNPLA8	50640	broad.mit.edu	37	7	108155563	108155563	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:108155563G>A	ENST00000426128.2	-	2	498	c.373C>T	c.(373-375)Cgt>Tgt	p.R125C	PNPLA8_ENST00000453144.1_Missense_Mutation_p.R25C|PNPLA8_ENST00000388728.5_Missense_Mutation_p.R125C|PNPLA8_ENST00000483879.1_Intron|PNPLA8_ENST00000422087.1_Missense_Mutation_p.R125C|PNPLA8_ENST00000436062.1_Missense_Mutation_p.R125C|PNPLA8_ENST00000257694.8_Missense_Mutation_p.R125C	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	125					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						TGAGCTAAACGTGAAATCATT	0.338000													28	43					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68628055	68628055	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:68628055G>A	ENST00000423218.2	-	12	1500	c.1405C>T	c.(1405-1407)Cag>Tag	p.Q469*	ITGA11_ENST00000315757.7_Nonsense_Mutation_p.Q469*			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	469					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	CGCATAGCCTGGTGGATGGTG	0.637000													10	9					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203680202	203680202	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:203680202C>T	ENST00000357681.5	+	12	3120	c.1997C>T	c.(1996-1998)gCg>gTg	p.A666V	ATP2B4_ENST00000341360.2_Missense_Mutation_p.A666V|ATP2B4_ENST00000391954.2_Missense_Mutation_p.A666V|ATP2B4_ENST00000367219.3_Missense_Mutation_p.A654V|ATP2B4_ENST00000367218.3_Missense_Mutation_p.A666V	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	666					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ACCTGTATCGCGGTGGTGGGC	0.557000													25	31					0	0	1	0	0
ZNF585A	199704	broad.mit.edu	37	19	37644232	37644232	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:37644232T>C	ENST00000356958.4	-	5	827	c.569A>G	c.(568-570)gAa>gGa	p.E190G	ZNF585A_ENST00000355533.2_Missense_Mutation_p.E135G|ZNF585A_ENST00000392157.2_Missense_Mutation_p.E135G|ZNF585A_ENST00000292841.5_Missense_Mutation_p.E135G|ZNF585A_ENST00000588723.1_Intron			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTTCCACATTCATTGCATTT	0.408000													24	112					0	0	1	0	0
FAAH	2166	broad.mit.edu	37	1	46874155	46874155	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:46874155C>T	ENST00000243167.8	+	8	1060	c.976C>T	c.(976-978)Cgt>Tgt	p.R326C	FAAH_ENST00000493735.1_3'UTR	NM_001441.2	NP_001432.2	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	326					fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	22	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	TCAGCCCCTGCGTGTGGGGTA	0.602000													95	147					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126241422	126241422	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126241422C>T	ENST00000394329.3	+	1	3869	c.3856C>T	c.(3856-3858)Caa>Taa	p.Q1286*		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1286	Cadherin 12.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCTTGTAATTCAAGCAGTGGA	0.373000													25	50					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6750939	6750939	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:6750939C>T	ENST00000378827.4	+	2	1385	c.166C>T	c.(166-168)Cgg>Tgg	p.R56W		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	56					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	GTTCGAGTTGCGGCTGCTCAG	0.667000													6	12					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153043066	153043066	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153043066G>A	ENST00000538966.1	+	32	5524	c.5253G>A	c.(5251-5253)ctG>ctA	p.L1751L	PLXNB3_ENST00000361971.5_Silent_p.L1728L|PLXNB3_ENST00000538776.1_Silent_p.L1381L|SRPK3_ENST00000489426.1_5'UTR|PLXNB3_ENST00000485980.1_3'UTR	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	1728					axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TCAAGTACCTGTTTGACCTTC	0.602000													47	5					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27761475	27761475	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:27761475C>T	ENST00000261588.4	+	16	3213	c.3194C>T	c.(3193-3195)aCg>aTg	p.T1065M		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1065								p.T1065M(2)		breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						ATTGACTTCACGCACCCTTGC	0.537000													16	19					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14037354	14037354	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:14037354C>T	ENST00000318003.7	+	18	2206	c.1965C>T	c.(1963-1965)aaC>aaT	p.N655N	CC2D1A_ENST00000589606.1_Silent_p.N655N	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	655	C2.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			TCAGCAGCAACGACATGCTCC	0.642000													8	23					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10539137	10539137	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:10539137C>T	ENST00000583535.1	-	29	3977	c.3890G>A	c.(3889-3891)aGc>aAc	p.S1297N	MYH3_ENST00000226209.7_Missense_Mutation_p.S1297N	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1297					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						GGATACTATGCTTTCTTTTTC	0.433000													59	100					0	0	1	0	0
FIP1L1	81608	broad.mit.edu	37	4	54256787	54256787	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:54256787G>A	ENST00000507166.1	+	7	497	c.497G>A	c.(496-498)cGt>cAt	p.R166H	FIP1L1_ENST00000507922.1_Missense_Mutation_p.R151H|FIP1L1_ENST00000358575.5_Missense_Mutation_p.R151H|FIP1L1_ENST00000337488.6_Missense_Mutation_p.R166H|FIP1L1_ENST00000306932.6_Missense_Mutation_p.R151H			Q6UN15	FIP1_HUMAN	factor interacting with PAPOLA and CPSF1	166	Necessary for stimulating PAPOLA activity.|Sufficient for interaction with CPSF4.				mRNA processing	nucleus	RNA binding			large_intestine(3)|liver(1)|ovary(1)|skin(1)	6			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			AAACCATGGCGTAAACCTGGT	0.318000			T	PDGFRA	idiopathic hypereosinophilic syndrome								18	30					0	0	1	0	0
ANXA4	307	broad.mit.edu	37	2	70047882	70047882	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:70047882G>T	ENST00000394295.4	+	12	1083	c.835G>T	c.(835-837)Gaa>Taa	p.E279*	ANXA4_ENST00000409920.1_Nonsense_Mutation_p.E257*|ANXA4_ENST00000536030.1_Nonsense_Mutation_p.E195*	NM_001153.3	NP_001144.1	P09525	ANXA4_HUMAN	annexin A4	277					anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11						TTCTCGAGCAGAAATTGACAT	0.438000													43	50					7.88023e-25	8.79368e-25	1	1	0
CADPS	8618	broad.mit.edu	37	3	62518602	62518602	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:62518602G>A	ENST00000383710.4	-	13	2584	c.2235C>T	c.(2233-2235)gaC>gaT	p.D745D	CADPS_ENST00000283269.9_Silent_p.D745D|CADPS_ENST00000357948.3_Silent_p.D728D	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	745					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GAAGGGTGGGGTCGATCATGG	0.522000													6	44					0	0	1	0	0
CPSF1	29894	broad.mit.edu	37	8	145622732	145622732	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145622732G>A	ENST00000349769.3	-	22	2449	c.2355C>T	c.(2353-2355)tgC>tgT	p.C785C		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	785					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GCACCAGCAGGCACCAGTGGG	0.682000													7	12					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93567736	93567736	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:93567736G>A	ENST00000394196.4	+	39	6356	c.5288G>A	c.(5287-5289)cGc>cAc	p.R1763H		NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1763					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GACCATTACCGCTCTTTCCAC	0.527000													12	36					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68205926	68205926	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:68205926C>T	ENST00000294304.7	+	20	4230	c.4124C>T	c.(4123-4125)cCg>cTg	p.P1375L		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	1375					adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ATCACCAAGCCGCCCTCAGAC	0.592000													14	34					0	0	1	0	0
CEBPE	1053	broad.mit.edu	37	14	23586748	23586748	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23586748C>T	ENST00000206513.5	-	2	1318	c.794G>A	c.(793-795)cGc>cAc	p.R265H		NM_001805.3	NP_001796.2	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein (C/EBP), epsilon	265	Leucine-zipper.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)	9	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		AGGAATCTGGCGGAAGAGGTT	0.647000													7	10					0	0	1	0	0
HMOX1	3162	broad.mit.edu	37	22	35782930	35782930	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:35782930G>A	ENST00000216117.8	+	3	736	c.397G>A	c.(397-399)Gcc>Acc	p.A133T		NM_002133.2	NP_002124.1	P09601	HMOX1_HUMAN	heme oxygenase (decycling) 1	133					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	16					NADH(DB00157)	GGTGGCCCACGCCTACACCCG	0.662000													17	24					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10742304	10742304	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10742304G>A	ENST00000586078.1	+	8	614	c.505G>A	c.(505-507)Gcc>Acc	p.A169T	SLC44A2_ENST00000335757.5_Missense_Mutation_p.A169T|SLC44A2_ENST00000407327.4_Missense_Mutation_p.A167T	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	169					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	CCATGCAGTGGCCCGGAGATG	0.607000													10	15					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161470982	161470982	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:161470982G>A	ENST00000392142.4	+	3	1826	c.1678G>A	c.(1678-1680)Gca>Aca	p.A560T	MAP3K4_ENST00000366920.2_Missense_Mutation_p.A560T|MAP3K4_ENST00000366919.2_Missense_Mutation_p.A560T|MAP3K4_ENST00000348824.7_Missense_Mutation_p.A560T	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	560					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GGCACGTATAGCATTGGTAAA	0.368000													5	89					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20555519	20555519	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:20555519C>T	ENST00000504154.1	+	26	2905	c.2653C>T	c.(2653-2655)Cgt>Tgt	p.R885C	SLIT2_ENST00000503837.1_Missense_Mutation_p.R881C|SLIT2_ENST00000503823.1_Missense_Mutation_p.R877C|SLIT2_ENST00000273739.5_Missense_Mutation_p.R889C	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	885	LRRCT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TGGAATTGCTCGTTGTGCTGG	0.408000													47	53					0	0	1	0	0
ARID3B	10620	broad.mit.edu	37	15	74883635	74883635	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:74883635C>T	ENST00000346246.5	+	6	1256	c.1025C>T	c.(1024-1026)gCg>gTg	p.A342V		NM_006465.2	NP_006456.1	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B (BRIGHT-like)	342	Interaction with RB1.|Poly-Ala.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(2)	14						TCACCTGCTGCGGCTACTGCT	0.647000													48	58					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128186326	128186326	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128186326C>T	ENST00000453608.2	+	8	1363	c.1355C>T	c.(1354-1356)gCc>gTc	p.A452V	PROC_ENST00000422777.3_Missense_Mutation_p.A397V|PROC_ENST00000409048.1_Missense_Mutation_p.A431V|PROC_ENST00000234071.3_Missense_Mutation_p.A397V			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	397					blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	CGGCAGGATGCCTGCGAGGGC	0.647000													40	48					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44067925	44067925	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:44067925C>T	ENST00000262726.7	-	15	1821	c.1568G>A	c.(1567-1569)cGc>cAc	p.R523H	EFCAB6_ENST00000396231.2_Missense_Mutation_p.R371H	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	523	EF-hand 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TCGGCCAATGCGCCCTGTGTC	0.333000													42	46					0	0	1	0	0
MAN2A2	4122	broad.mit.edu	37	15	91455466	91455466	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:91455466G>A	ENST00000360468.3	+	14	2321	c.2303G>A	c.(2302-2304)cGc>cAc	p.R768H	MAN2A2_ENST00000559717.1_Missense_Mutation_p.R768H|MAN2A2_ENST00000430376.2_5'UTR|MAN2A2_ENST00000431652.2_Missense_Mutation_p.R276H	NM_006122.2	NP_006113.2	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	768					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CTCAGCAACCGCTACATGCAG	0.627000													31	42					0	0	1	0	0
FTSJD2	0	broad.mit.edu	37	6	37421017	37421017	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:37421017G>A	ENST00000373451.4	+	8	870	c.704_splice	c.e8-1	p.A236_splice		NM_015050.2	NP_055865.1	Q8N1G2	MTR1_HUMAN		236					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(6)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(2)	31						TTATTGCAGGGCAGCAATGAA	0.448000													41	68					0	0	1	0	0
SLC38A11	151258	broad.mit.edu	37	2	165755097	165755097	+	Silent	SNP	G	G	A	rs146184099		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:165755097G>A	ENST00000303735.4	-	10	1335	c.1005C>T	c.(1003-1005)ttC>ttT	p.F335F	SLC38A11_ENST00000409662.1_Silent_p.F357F|SLC38A11_ENST00000409149.3_Silent_p.F357F|SLC38A11_ENST00000409058.1_Silent_p.F388F	NM_173512.2	NP_775783.1	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	357					amino acid transport|sodium ion transport	integral to membrane				endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15						TAGCCATGACGAATCCAAAAA	0.433000													14	25					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78907174	78907174	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:78907174C>T	ENST00000545128.1	+	25	3706	c.3168C>T	c.(3166-3168)tgC>tgT	p.C1056C		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	756					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GTACATCTTGCGCTATGGGGT	0.358000													17	84					0	0	1	0	0
CREB3	10488	broad.mit.edu	37	9	35733078	35733078	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35733078C>T	ENST00000353704.2	+	2	653	c.215C>T	c.(214-216)cCc>cTc	p.P72L	CREB3_ENST00000486056.1_3'UTR	NM_006368.4	NP_006359.3	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	72	Transcription activation (acidic).				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|urinary_tract(1)	9	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		TCCTCCAACCCCTGCCTTGTC	0.557000													16	30					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38328608	38328608	+	Missense_Mutation	SNP	G	G	A	rs142424154		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38328608G>A	ENST00000215957.6	+	11	2191	c.2065G>A	c.(2065-2067)Gat>Aat	p.D689N	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	689						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					TGGAGAGATGGATACCATTGA	0.657000													20	18					0	0	1	0	0
SBSN	374897	broad.mit.edu	37	19	36017621	36017621	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36017621G>A	ENST00000452271.2	-	1	1591	c.1563C>T	c.(1561-1563)ggC>ggT	p.G521G	SBSN_ENST00000518157.1_Silent_p.G178G	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	178						extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TCCCGGCCTGGCCAGCAGCAT	0.577000													29	53					0	0	1	0	0
DDX10	1662	broad.mit.edu	37	11	108788748	108788748	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:108788748A>T	ENST00000526794.1	+	17	2485	c.2453A>T	c.(2452-2454)tAt>tTt	p.Y818F	DDX10_ENST00000322536.3_Intron			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	0							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		AAAATAAGGTATGTTTTTACT	0.333000			T	NUP98	AML*								24	32					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98761034	98761034	+	Missense_Mutation	SNP	C	C	T	rs143588507		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:98761034C>T	ENST00000371070.4	-	37	4399	c.4316G>A	c.(4315-4317)cGc>cAc	p.R1439H	SLIT1_ENST00000266058.4_Silent_p.T1480T|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR			O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1128	EGF-like 9.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding	p.T1480T(1)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		ACAGGGGGCGCGTGGTCTGGC	0.657000													29	46					0	0	1	0	0
SLAIN2	57606	broad.mit.edu	37	4	48422198	48422198	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:48422198C>T	ENST00000264313.6	+	7	1835	c.1417C>T	c.(1417-1419)Caa>Taa	p.Q473*	SLAIN2_ENST00000512093.1_Nonsense_Mutation_p.Q306*	NM_020846.1	NP_065897.1	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	473						centrosome				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)	13						GGCTCTTCGGCAACCAGTGAA	0.488000													18	22					0	0	1	0	0
BBS4	585	broad.mit.edu	37	15	73029851	73029851	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:73029851C>T	ENST00000268057.4	+	16	1524	c.1483C>T	c.(1483-1485)Cca>Tca	p.P495S	BBS4_ENST00000539603.1_Missense_Mutation_p.P483S|BBS4_ENST00000395205.2_Missense_Mutation_p.P503S|BBS4_ENST00000542334.1_Missense_Mutation_p.P323S	NM_033028.4	NP_149017.2	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	495	Required for localization to centrosomes.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity			autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(1)	19						CACAAAGCCCCCATCTCTTCC	0.403000									Bardet-Biedl syndrome				3	18					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140074793	140074793	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140074793T>C	ENST00000323927.2	-	10	1734	c.1730A>G	c.(1729-1731)gAg>gGg	p.E577G		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	577					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		CTTCTCATCCTCCTCCCGGAT	0.682000													19	34					0	0	1	0	0
CDS2	8760	broad.mit.edu	37	20	5159511	5159511	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:5159511G>A	ENST00000460006.1	+	5	745	c.438G>A	c.(436-438)acG>acA	p.T146T	CDS2_ENST00000379070.3_3'UTR|CDS2_ENST00000379062.4_Silent_p.T26T|CDS2_ENST00000535100.1_5'UTR	NM_003818.3	NP_003809.1	O95674	CDS2_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2	146					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|stomach(1)	14						AGACAGTGACGGATTACTTCT	0.448000													35	47					0	0	1	0	0
ALDH6A1	4329	broad.mit.edu	37	14	74535652	74535652	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:74535652T>C	ENST00000553458.1	-	7	861	c.763A>G	c.(763-765)Aaa>Gaa	p.K255E	ALDH6A1_ENST00000350259.4_Missense_Mutation_p.K242E|AC005484.5_ENST00000492026.1_RNA|CCDC176_ENST00000553773.1_Intron|ALDH6A1_ENST00000555126.1_5'UTR	NM_001278593.1|NM_005589.2	NP_001265522.1|NP_005580.1	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6 family, member A1	255						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(3)|skin(3)	21				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	CTGATTGCTTTGATGTCCGGA	0.403000													7	42					0	0	1	0	0
PRRC2B	84726	broad.mit.edu	37	9	134351102	134351102	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:134351102C>T	ENST00000357304.4	+	15	3641	c.3586C>T	c.(3586-3588)Cga>Tga	p.R1196*	PRRC2B_ENST00000372249.1_5'UTR|PRRC2B_ENST00000458550.1_Intron|PRRC2B_ENST00000405995.1_Intron	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	1196							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						TGCCAAGAGCCGAGGCCCTCG	0.622000													3	10					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714946	92714946	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:92714946G>A	ENST00000257068.2	+	2	563	c.557G>A	c.(556-558)cGc>cAc	p.R186H		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	186					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	TACGACCCACGCATCTATTCC	0.617000													6	11					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183696309	183696309	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:183696309G>A	ENST00000334444.6	-	9	1518	c.1278C>T	c.(1276-1278)ttC>ttT	p.F426F	ABCC5_ENST00000265586.6_Silent_p.F426F|ABCC5_ENST00000492216.1_5'UTR	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	426	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CTGTCAGATCGAAGCCCAGGG	0.517000													8	33					0	0	1	0	0
ELMOD2	255520	broad.mit.edu	37	4	141471406	141471406	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:141471406C>T	ENST00000323570.3	+	9	891	c.759C>T	c.(757-759)gaC>gaT	p.D253D		NM_153702.3	NP_714913.1	Q8IZ81	ELMD2_HUMAN	ELMO/CED-12 domain containing 2	253	ELMO.				phagocytosis|regulation of defense response to virus|response to virus	cytoskeleton	GTPase activator activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	7	all_hematologic(180;0.162)					ATGAATTTGACAAGTTTTGGT	0.294000													12	28					0	0	1	0	0
FAM91A1	157769	broad.mit.edu	37	8	124799552	124799552	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:124799552G>A	ENST00000334705.7	+	13	1376	c.1130G>A	c.(1129-1131)cGc>cAc	p.R377H	FAM91A1_ENST00000521166.1_Missense_Mutation_p.R377H	NM_144963.2	NP_659400.2	Q658Y4	F91A1_HUMAN	family with sequence similarity 91, member A1	377										breast(4)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			CACACGAAGCGCATCGCATTC	0.388000													12	27					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2691278	2691278	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2691278G>A	ENST00000324666.5	+	12	1855	c.1504G>A	c.(1504-1506)Gta>Ata	p.V502I	FAM193A_ENST00000505311.1_Missense_Mutation_p.V502I|FAM193A_ENST00000502458.1_Missense_Mutation_p.V524I|FAM193A_ENST00000545951.1_Missense_Mutation_p.V502I|FAM193A_ENST00000382839.3_Missense_Mutation_p.V502I	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	502										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						TAAGCATCAGGTATTCAATGC	0.348000													40	52					0	0	1	0	0
NPIPB15	440348	broad.mit.edu	37	16	74425467	74425467	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:74425467T>C	ENST00000429990.1	+	7	917	c.821T>C	c.(820-822)cTt>cCt	p.L274P						nuclear pore complex interacting protein family, member B15																		CTTCATCCCCTTCCACCCTCA	0.507000													8	195					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87138668	87138668	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:87138668G>A	ENST00000265724.3	-	27	3829	c.3412C>T	c.(3412-3414)Cgg>Tgg	p.R1138W	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Missense_Mutation_p.R1074W	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1138	ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GACACCACCCGGCTGTTGTCT	0.512000													32	63					0	0	1	0	0
RPL6	6128	broad.mit.edu	37	12	112846078	112846078	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112846078T>C	ENST00000424576.2	-	3	487	c.302A>G	c.(301-303)aAc>aGc	p.N101S	RPL6_ENST00000202773.9_Missense_Mutation_p.N101S	NM_001024662.1	NP_001019833.1	Q02878	RL6_HUMAN	ribosomal protein L6	101					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			cervix(1)|large_intestine(6)|lung(3)	10						GGTACCGCCGTTCTTGTCACC	0.403000													5	68					0	0	1	0	0
ADTRP	84830	broad.mit.edu	37	6	11714746	11714746	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:11714746C>A	ENST00000414691.3	-	6	1069		c.e6-1		ADTRP_ENST00000229583.5_Splice_Site|ADTRP_ENST00000514824.1_Splice_Site	NM_032744.3	NP_116133.1	Q96IZ2	CF105_HUMAN	androgen-dependent TFPI-regulating protein							integral to membrane											CTCATGTCACCTGTACAAACA	0.423000													35	31					1.47197e-15	1.61186e-15	1	1	0
PPP3CC	5533	broad.mit.edu	37	8	22398279	22398279	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22398279G>A	ENST00000240139.5	+	14	1830	c.1503G>A	c.(1501-1503)gcG>gcA	p.A501A	PPP3CC_ENST00000397775.3_Silent_p.A510A|PPP3CC_ENST00000289963.8_Silent_p.A491A	NM_005605.4	NP_005596.2	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma isozyme	501			A -> V (in dbSNP:rs28764007).		activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		CACATGCTGCGCACAGGAGCG	0.473000													12	15					0	0	1	0	0
ARRDC4	91947	broad.mit.edu	37	15	98511267	98511267	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:98511267G>T	ENST00000268042.6	+	4	710	c.546G>T	c.(544-546)gaG>gaT	p.E182D	ARRDC4_ENST00000538249.1_Missense_Mutation_p.E95D	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	182					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			AAACTCAAGAGAAAATGGTTG	0.348000													21	29					1.55795e-14	1.69983e-14	1	1	0
TPR	7175	broad.mit.edu	37	1	186326648	186326648	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:186326648C>A	ENST00000367478.3	-	14	1901	c.1605G>T	c.(1603-1605)caG>caT	p.Q535H	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	535					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		ATACTAGATGCTGTGATATTA	0.403000			T	NTRK1	papillary thyroid								33	44					1.22384e-17	1.34778e-17	1	1	0
ITGA2B	3674	broad.mit.edu	37	17	42461310	42461310	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42461310G>A	ENST00000262407.5	-	11	981	c.950C>T	c.(949-951)gCg>gTg	p.A317V	ITGA2B_ENST00000353281.4_Missense_Mutation_p.A317V|ITGA2B_ENST00000377068.3_Missense_Mutation_p.A2V	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	317					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	AAAATACGACGCCATCTGCAA	0.532000													11	3					0	0	1	0	0
GOLM1	51280	broad.mit.edu	37	9	88650460	88650460	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:88650460C>T	ENST00000388712.3	-	8	1006	c.838G>A	c.(838-840)Gtg>Atg	p.V280M	GOLM1_ENST00000388711.3_Missense_Mutation_p.V280M	NM_016548.3	NP_057632.2	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1	280						Golgi apparatus|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17						CTGTCTTCCACCACCTGCTCC	0.607000											OREG0019278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	54	87					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87196170	87196170	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:87196170G>T	ENST00000265724.3	-	7	878	c.461C>A	c.(460-462)gCt>gAt	p.A154D	ABCB1_ENST00000543898.1_Intron	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	154	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCGCATTATAGCATGAAAAAA	0.423000													22	44					5.45024e-15	5.96122e-15	1	1	0
ZNF616	90317	broad.mit.edu	37	19	52619169	52619169	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:52619169C>T	ENST00000600228.1	-	4	1509	c.1248G>A	c.(1246-1248)aaG>aaA	p.K416K	ZNF616_ENST00000330123.5_3'UTR	NM_178523.3	NP_848618.2	Q08AN1	ZN616_HUMAN	zinc finger protein 616	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TACTGAAGACCTTGCCACATT	0.408000													21	167					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906130	164906130	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:164906130A>G	ENST00000475390.1	-	2	2932	c.2489T>C	c.(2488-2490)aTa>aCa	p.I830T	SLITRK3_ENST00000241274.3_Missense_Mutation_p.I830T			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	830						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CACCGTCACTATGGTGTTAAG	0.552000										HNSCC(40;0.11)			18	39					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47247084	47247084	+	Silent	SNP	C	C	T	rs147352919		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:47247084C>T	ENST00000300404.2	+	11	1754	c.1695C>T	c.(1693-1695)gcC>gcT	p.A565A	B4GALNT2_ENST00000393354.2_Silent_p.A505A|B4GALNT2_ENST00000504681.1_Silent_p.A479A	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	565					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			TCCAATGTGCCGCATAAAGGT	0.512000													12	31					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141750044	141750044	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:141750044C>T	ENST00000475668.2	+	23	2651	c.2597C>T	c.(2596-2598)gCc>gTc	p.A866V	MGAM_ENST00000549489.2_Missense_Mutation_p.A866V			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	866	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GATACTGTGGCCAATAAAGTG	0.423000													18	54					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19178854	19178854	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19178854G>A	ENST00000263200.10	-	27	4357	c.4285C>T	c.(4285-4287)Cgg>Tgg	p.R1429W	CLTCL1_ENST00000353891.5_Missense_Mutation_p.R1429W|CLTCL1_ENST00000427926.1_Missense_Mutation_p.R1429W|CLTCL1_ENST00000442042.2_5'UTR	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1429	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					TGGTCCAGCCGGGGTGAAAGC	0.493000			T	?	ALCL								30	35					0	0	1	0	0
PAX8	7849	broad.mit.edu	37	2	113977703	113977703	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:113977703G>A	ENST00000348715.5	-	11	1318	c.1163C>T	c.(1162-1164)gCg>gTg	p.A388V	PAX8_ENST00000263334.5_Missense_Mutation_p.A388V|PAX8_ENST00000263335.7_Missense_Mutation_p.A311V|AC016683.6_ENST00000456685.1_RNA|PAX8_ENST00000429538.3_Silent_p.S414S|PAX8_ENST00000397647.3_Missense_Mutation_p.A277V	NM_013952.3	NP_039246.1	Q06710	PAX8_HUMAN	paired box 8	0					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						GCCAGGCCTCGCTGTAGGAGG	0.617000			T	PPARG	follicular thyroid		Thyroid dysgenesis						7	14					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53445735	53445735	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53445735G>A	ENST00000314250.6	+	2	462	c.172G>A	c.(172-174)Gtt>Att	p.V58I	TENC1_ENST00000451358.1_Missense_Mutation_p.V58I|RP11-983P16.4_ENST00000550601.1_RNA|RP11-983P16.4_ENST00000546793.1_RNA|TENC1_ENST00000546602.1_Missense_Mutation_p.V58I|TENC1_ENST00000549700.1_Missense_Mutation_p.V58I|TENC1_ENST00000552570.1_Missense_Mutation_p.V58I|TENC1_ENST00000379902.3_5'UTR|TENC1_ENST00000314276.3_Missense_Mutation_p.V68I	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	58					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						TGGGACAGGCGTTTCGTGCAG	0.542000													15	34					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17212765	17212765	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17212765G>A	ENST00000595618.1	+	2	390	c.238G>A	c.(238-240)Gcc>Acc	p.A80T	MYO9B_ENST00000397274.2_Missense_Mutation_p.A80T|MYO9B_ENST00000594824.1_Missense_Mutation_p.A80T	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	80	Myosin head-like.|Ras-associating.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						GGTGCTGGACGCCAACGACTC	0.632000													7	26					0	0	1	0	0
STRIP1	85369	broad.mit.edu	37	1	110584162	110584162	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110584162C>A	ENST00000369795.3	+	7	677	c.655C>A	c.(655-657)Ctg>Atg	p.L219M	STRIP1_ENST00000369796.1_Missense_Mutation_p.L124M	NM_033088.2	NP_149079.2			striatin interacting protein 1																		CCTCAGGGTCCTGCTCAACAT	0.547000													9	24					0.000274275	0.000279654	1	1	0
ZFAT	57623	broad.mit.edu	37	8	135649893	135649893	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:135649893C>A	ENST00000520727.1	-	4	522	c.223G>T	c.(223-225)Gaa>Taa	p.E75*	ZFAT_ENST00000520356.1_Nonsense_Mutation_p.E75*|ZFAT_ENST00000429442.2_Nonsense_Mutation_p.E75*|ZFAT_ENST00000520214.1_Nonsense_Mutation_p.E75*|ZFAT_ENST00000523399.1_Nonsense_Mutation_p.E87*|ZFAT_ENST00000377838.3_Nonsense_Mutation_p.E87*	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			AGCTCCTCTTCTGTGCTGGAC	0.547000													5	96					0.014758	0.0148771	1	1	0
STAU2	27067	broad.mit.edu	37	8	74600977	74600977	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:74600977C>A	ENST00000355780.5	-	4	308	c.90G>T	c.(88-90)caG>caT	p.Q30H	STAU2_ENST00000517542.1_Missense_Mutation_p.Q24H|RP11-463D19.2_ENST00000358757.5_3'UTR|STAU2_ENST00000522509.1_Missense_Mutation_p.Q30H|STAU2_ENST00000522695.1_Missense_Mutation_p.Q30H|STAU2_ENST00000519961.1_Missense_Mutation_p.Q62H|STAU2_ENST00000522962.1_5'UTR|STAU2_ENST00000521419.1_Missense_Mutation_p.Q24H|RP11-463D19.1_ENST00000533978.1_lincRNA|STAU2_ENST00000523558.1_Intron|STAU2_ENST00000524300.1_Missense_Mutation_p.Q62H|STAU2_ENST00000521727.1_Missense_Mutation_p.Q42H|STAU2_ENST00000521451.1_Intron|STAU2_ENST00000524104.1_Missense_Mutation_p.Q30H|STAU2_ENST00000521210.1_Intron	NM_014393.2	NP_055208.2	Q9NUL3	STAU2_HUMAN	staufen double-stranded RNA binding protein 2	62	DRBM 1.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)	19	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			CAACAGCCTGCTGAGCCTTCT	0.428000													59	87					5.82218e-30	6.52265e-30	1	1	0
TFIP11	24144	broad.mit.edu	37	22	26888203	26888203	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:26888203C>T	ENST00000407690.1	-	15	2573	c.2290G>A	c.(2290-2292)Gtg>Atg	p.V764M	TFIP11_ENST00000407148.1_Missense_Mutation_p.V764M|TFIP11_ENST00000407431.1_Missense_Mutation_p.V764M|TFIP11_ENST00000405938.1_Missense_Mutation_p.V764M	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	764					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						CTAGCGGCCACGCCAATGCCC	0.572000													20	26					0	0	1	0	0
IRS1	3667	broad.mit.edu	37	2	227662817	227662817	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:227662817C>T	ENST00000305123.4	-	1	1658	c.638G>A	c.(637-639)cGc>cAc	p.R213H		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1	213	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GTGGCCACAGCGCCTGATGTT	0.597000											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	29					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171174642	171174642	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:171174642C>T	ENST00000441535.1	+	7	1169	c.1052C>T	c.(1051-1053)tCa>tTa	p.S351L	RP1-127D3.4_ENST00000422841.1_RNA|FMO2_ENST00000209929.7_Missense_Mutation_p.S351L|FMO2_ENST00000529935.1_3'UTR|RP1-127D3.4_ENST00000445909.1_RNA|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445290.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	351					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AATATGGTCTCACTGTATAAA	0.428000													15	26					0	0	1	0	0
CX3CL1	6376	broad.mit.edu	37	16	57413554	57413554	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57413554C>A	ENST00000006053.6	+	2	190	c.79C>A	c.(79-81)Cac>Aac	p.H27N	CX3CL1_ENST00000565912.1_5'UTR|CX3CL1_ENST00000564948.1_Intron|CX3CL1_ENST00000563383.1_Missense_Mutation_p.H33N	NM_002996.3	NP_002987.1	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1	27	Chemokine.				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5						AGGACAGCACCACGGTGTGAC	0.537000													11	21					4.68919e-08	4.93693e-08	1	1	0
SCN10A	6336	broad.mit.edu	37	3	38783942	38783942	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38783942G>T	ENST00000449082.2	-	13	1945	c.1946C>A	c.(1945-1947)cCc>cAc	p.P649H		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	649					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CACCCACATGGGGCAGCAATC	0.502000													23	45					2.32416e-17	2.5579e-17	1	1	0
AJUBA	84962	broad.mit.edu	37	14	23444069	23444069	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23444069G>A	ENST00000262713.2	-	6	1776	c.1401C>T	c.(1399-1401)ggC>ggT	p.G467G	RP11-298I3.5_ENST00000555074.1_Intron|AJUBA_ENST00000397388.3_Silent_p.G50G|AJUBA_ENST00000361265.4_Silent_p.G467G	NM_032876.4	NP_116265.1	Q96IF1	JUB_HUMAN	ajuba LIM protein	467	LIM zinc-binding 3.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding										GGATGGGTTGGCCACAGGCTG	0.572000													15	17					0	0	1	0	0
PHACTR4	65979	broad.mit.edu	37	1	28793151	28793151	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:28793151G>T	ENST00000373839.3	+	6	956	c.695G>T	c.(694-696)aGg>aTg	p.R232M	PHACTR4_ENST00000493669.1_3'UTR|PHACTR4_ENST00000373836.3_Missense_Mutation_p.R242M	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	232	Pro-rich.						actin binding|protein phosphatase inhibitor activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGCACCCAGGACTCTGCCT	0.582000													19	27					2.94398e-08	3.10271e-08	1	1	0
ZDHHC17	23390	broad.mit.edu	37	12	77244672	77244672	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:77244672C>T	ENST00000426126.2	+	17	2455	c.1806C>T	c.(1804-1806)tgC>tgT	p.C602C	ZDHHC17_ENST00000334822.5_Silent_p.C602C	NM_015336.2	NP_056151.2	Q8IUH5	ZDH17_HUMAN	zinc finger, DHHC-type containing 17	602					lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding			breast(2)|endometrium(2)|large_intestine(3)|liver(2)|lung(14)	23						AATTTCGATGCTGTGGCCTCT	0.408000													36	68					0	0	1	0	0
SMOX	54498	broad.mit.edu	37	20	4167394	4167394	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:4167394G>A	ENST00000278795.3	+	8	1601	c.1376G>A	c.(1375-1377)gGa>gAa	p.G459E	SMOX_ENST00000346595.2_Intron|SMOX_ENST00000379460.2_Intron|SMOX_ENST00000305958.4_Intron|SMOX_ENST00000339123.6_Intron	NM_175842.1	NP_787036.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	510					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	caccagcatggaagctccaca	0.512000													17	96					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42585299	42585299	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42585299G>A	ENST00000600245.1	+	2	3196	c.2541G>A	c.(2539-2541)caG>caA	p.Q847Q	ZNF574_ENST00000359044.4_Silent_p.Q847Q|ZNF574_ENST00000222339.7_Silent_p.Q937Q			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	847					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				ATCAGCAGCAGCATCAGGCAG	0.642000													7	50					0	0	1	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40845554	40845554	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40845554G>A	ENST00000264638.4	+	18	3209	c.2992_splice	c.e18+1	p.D998_splice	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	998					axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		CTGCAACCACGGTAAGTGCTG	0.542000													12	70					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101727206	101727206	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:101727206G>A	ENST00000261637.4	+	28	3719	c.3545G>A	c.(3544-3546)gGt>gAt	p.G1182D		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1182					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						GTGTTTCATGGTGCAGTTTGG	0.378000													55	71					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103900822	103900822	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:103900822C>T	ENST00000278070.2	+	5	2596	c.2557C>T	c.(2557-2559)Cca>Tca	p.P853S	PPRC1_ENST00000413464.2_Missense_Mutation_p.P853S	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	853	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CCAGGAGATGCCACTGTTGGC	0.617000													19	22					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61557711	61557711	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61557711G>T	ENST00000290866.4	+	5	693	c.669G>T	c.(667-669)acG>acT	p.T223T	ACE_ENST00000584529.1_3'UTR|ACE_ENST00000428043.1_Silent_p.T223T|ACE_ENST00000538928.1_Silent_p.T223T	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	223	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TCACAGACACGGGGGCCTACT	0.612000													7	15					1.12685e-05	1.16601e-05	1	1	0
MYCBP2	23077	broad.mit.edu	37	13	77671856	77671856	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:77671856A>G	ENST00000407578.2	-	56	9699	c.9433T>C	c.(9433-9435)Tcc>Ccc	p.S3145P	MYCBP2-AS1_ENST00000593933.1_RNA|MYCBP2_ENST00000544440.2_Missense_Mutation_p.S3107P|MYCBP2_ENST00000357337.6_Missense_Mutation_p.S3107P	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTATGCATGGACATTTCAAAA	0.403000													24	11					0	0	1	0	0
ANKRD49	54851	broad.mit.edu	37	11	94231249	94231249	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:94231249C>T	ENST00000544612.1	+	3	768	c.271C>T	c.(271-273)Cgg>Tgg	p.R91W	ANKRD49_ENST00000538535.1_3'UTR|ANKRD49_ENST00000544253.1_3'UTR|ANKRD49_ENST00000540349.1_3'UTR|ANKRD49_ENST00000302755.4_Missense_Mutation_p.R91W	NM_017704.2	NP_060174.2	Q8WVL7	ANR49_HUMAN	ankyrin repeat domain 49	91					positive regulation of transcription, DNA-dependent			p.R91W(2)		autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|urinary_tract(1)	12		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TACCACAGTGCGGAGACTCCT	0.383000													10	16					0	0	1	0	0
ARRDC4	91947	broad.mit.edu	37	15	98512457	98512457	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:98512457A>G	ENST00000268042.6	+	5	894	c.730A>G	c.(730-732)Aca>Gca	p.T244A	ARRDC4_ENST00000538249.1_Missense_Mutation_p.T157A	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	244					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			TAGTGGAAAAACAAAGACCAT	0.438000													21	31					0	0	1	0	0
WISP3	8838	broad.mit.edu	37	6	112386138	112386138	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:112386138A>G	ENST00000361714.1	+	3	626	c.581A>G	c.(580-582)cAg>cGg	p.Q194R	WISP3_ENST00000409166.1_5'UTR|WISP3_ENST00000604763.1_Missense_Mutation_p.Q176R|WISP3_ENST00000368663.3_Missense_Mutation_p.Q153R|WISP3_ENST00000368666.2_Missense_Mutation_p.Q176R|WISP3_ENST00000230529.5_Missense_Mutation_p.Q176R			O95389	WISP3_HUMAN	WNT1 inducible signaling pathway protein 3	176					cell-cell signaling|regulation of cell growth|signal transduction	extracellular region|soluble fraction	growth factor activity|insulin-like growth factor binding			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	13		all_cancers(87;0.000196)|Acute lymphoblastic leukemia(125;1.18e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0283)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0827)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		AAGTCTGATCAGTCAAACTGT	0.478000													41	51					0	0	1	0	0
NPRL3	8131	broad.mit.edu	37	16	169162	169162	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:169162A>G	ENST00000399953.3	-	3	683	c.281T>C	c.(280-282)gTt>gCt	p.V94A	NPRL3_ENST00000405960.3_5'UTR|NPRL3_ENST00000399951.3_Intron	NM_001077350.2|NM_001243247.1|NM_001243248.1|NM_001243249.1	NP_001070818.1|NP_001230176.1|NP_001230177.1|NP_001230178.1	Q12980	NPRL3_HUMAN	nitrogen permease regulator-like 3 (S. cerevisiae)	94							protein binding			endometrium(1)|large_intestine(3)|ovary(2)	6						TGGGTGCCCAACAAATCGCAC	0.493000													3	4					0	0	1	0	0
RANGRF	29098	broad.mit.edu	37	17	8193159	8193159	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8193159G>A	ENST00000226105.6	+	5	758	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	SLC25A35_ENST00000580340.1_Intron|SLC25A35_ENST00000396278.1_Intron|RANGRF_ENST00000439238.3_3'UTR|SLC25A35_ENST00000380067.2_Intron|RANGRF_ENST00000407006.4_3'UTR|RANGRF_ENST00000580434.1_3'UTR|SLC25A35_ENST00000579192.1_Intron	NM_016492.4	NP_057576.2	Q9HD47	MOG1_HUMAN	RAN guanine nucleotide release factor	156					protein transport	cytoplasm|nucleus	guanyl-nucleotide exchange factor activity			endometrium(1)	1						TCTTGGCCCCGAAAATCTGTC	0.537000													36	64					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66461160	66461160	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:66461160G>A	ENST00000404260.3	+	29	6470	c.6162G>A	c.(6160-6162)gcG>gcA	p.A2054A	MAST4_ENST00000261569.7_Silent_p.A1857A|MAST4_ENST00000403625.2_Silent_p.A2051A|MAST4_ENST00000403666.1_Silent_p.A1862A|MAST4_ENST00000405643.1_Silent_p.A1872A			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	2054						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CAGGTGAGGCGAGGCCCCCGC	0.607000													12	21					0	0	1	0	0
SP110	3431	broad.mit.edu	37	2	231050721	231050721	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:231050721G>A	ENST00000258381.6	-	11	1345	c.1268C>T	c.(1267-1269)tCc>tTc	p.S423F	SP110_ENST00000392048.3_Missense_Mutation_p.S421F|SP110_ENST00000338556.3_Missense_Mutation_p.S125F|SP110_ENST00000540870.1_Missense_Mutation_p.S429F|SP110_ENST00000358662.4_Missense_Mutation_p.S423F|SP110_ENST00000258382.5_Missense_Mutation_p.S423F	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	423					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		TTTCAATCTGGACTTTCGGGC	0.448000													53	81					0	0	1	0	0
NBR1	4077	broad.mit.edu	37	17	41345493	41345493	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41345493G>A	ENST00000422280.1	+	12	1821	c.1362G>A	c.(1360-1362)acG>acA	p.T454T	NBR1_ENST00000341165.6_Silent_p.T454T|NBR1_ENST00000590996.1_Silent_p.T454T|NBR1_ENST00000589872.1_Silent_p.T454T|NBR1_ENST00000542611.1_Silent_p.T433T|NBR1_ENST00000389312.4_Silent_p.T454T	NM_031858.2	NP_114064.1	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	454					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	24		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		TGGAGGGAACGTATACTTCCC	0.532000													12	17					0	0	1	0	0
NRIP2	83714	broad.mit.edu	37	12	2936801	2936801	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:2936801A>T	ENST00000337508.4	-	5	783	c.743T>A	c.(742-744)cTt>cAt	p.L248H	ITFG2_ENST00000542548.1_Intron	NM_031474.2	NP_113662.1	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	248					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			CTTGAGAGAAAGCAGAGTCTG	0.527000													14	125					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156589546	156589546	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:156589546G>A	ENST00000302938.4	-	2	1825	c.1730C>T	c.(1729-1731)gCc>gTc	p.A577V		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	577						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCCACCCTGGGCTTTCTCCAC	0.483000													64	100					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92470564	92470564	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:92470564C>A	ENST00000267622.4	-	11	4129	c.3756G>T	c.(3754-3756)caG>caT	p.Q1252H		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1252					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		CAACCAAAACCTGTGCTTGAA	0.413000			T	PDGFRB	AML								21	22					1.50039e-11	1.61536e-11	1	1	0
IGHV3-23	0	broad.mit.edu	37	14	106725634	106725634	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:106725634C>T	ENST00000390609.2	-	0	99																											CAAGAAAAAGCCAGCTCAGCC	0.438000													6	126					0	0	1	0	0
MRPL39	54148	broad.mit.edu	37	21	26961154	26961154	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:26961154C>T	ENST00000307301.7	-	9	1003	c.962G>A	c.(961-963)cGg>cAg	p.R321Q	MRPL39_ENST00000352957.4_Missense_Mutation_p.R321Q	NM_080794.3	NP_542984.2	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39	321						mitochondrial ribosome	nucleotide binding			endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	10						TACCATTTTCCGAGATCTTTC	0.323000													44	22					0	0	1	0	0
AKR7L	246181	broad.mit.edu	37	1	19600455	19600455	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:19600455G>A	ENST00000420396.2	-	0	113				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						CGGTGTGGCCGCGCTCCAGGA	0.716000													3	1					0	0	1	0	0
CHD6	0	broad.mit.edu	37	20	40102132	40102132	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:40102132G>A	ENST00000373233.3	-	17	2671	c.2494C>T	c.(2494-2496)Cga>Tga	p.R832*	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	832	Helicase C-terminal.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CCCCGTACTCGCCCATCAATT	0.537000													25	25					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3707219	3707219	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3707219G>A	ENST00000324932.7	-	29	5080	c.4660C>T	c.(4660-4662)Cac>Tac	p.H1554Y	NUP98_ENST00000359171.4_Intron|NUP98_ENST00000355260.3_Intron	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1571					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TTGTCAATGTGCAGGAGGACA	0.532000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								31	47					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47253964	47253964	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:47253964C>A	ENST00000296861.2	-	2	857	c.464G>T	c.(463-465)gGt>gTt	p.G155V		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	155					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			CTTCCGCACACCCCAACCCAC	0.552000													30	47					2.61193e-14	2.84738e-14	1	1	0
SUPT16H	11198	broad.mit.edu	37	14	21829364	21829364	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:21829364C>T	ENST00000216297.2	-	16	2140	c.1802G>A	c.(1801-1803)cGa>cAa	p.R601Q		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	601					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		ATTTGATGCTCGGTATGTACT	0.368000													35	67					0	0	1	0	0
ADCK2	90956	broad.mit.edu	37	7	140373595	140373595	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:140373595G>A	ENST00000072869.4	+	1	643	c.465G>A	c.(463-465)cgG>cgA	p.R155R	ADCK2_ENST00000476491.1_Silent_p.R155R	NM_052853.3	NP_443085.2	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	155						integral to membrane	ATP binding|protein serine/threonine kinase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|skin(4)	15	Melanoma(164;0.00956)					CCAGCACCCGGCGCGATCTGT	0.617000													21	42					0	0	1	0	0
SEC24B	10427	broad.mit.edu	37	4	110394176	110394176	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:110394176C>A	ENST00000265175.5	+	3	949	c.894C>A	c.(892-894)tcC>tcA	p.S298S	SEC24B_ENST00000399100.2_Silent_p.S298S|SEC24B_ENST00000504968.2_Silent_p.S329S	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	298					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		ATTCTTTATCCTGTCCTGTTA	0.363000													22	31					7.92952e-12	8.55149e-12	1	1	0
EFCAB7	84455	broad.mit.edu	37	1	63999837	63999837	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:63999837G>A	ENST00000371088.4	+	6	1000	c.754G>A	c.(754-756)Ggg>Agg	p.G252R		NM_032437.2	NP_115813.2	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	252							calcium ion binding			breast(1)|endometrium(4)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	19						AGTTACCATGGGGGCTAATGG	0.353000													21	81					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21501508	21501508	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:21501508C>T	ENST00000313654.9	+	62	8377	c.8136C>T	c.(8134-8136)agC>agT	p.S2712S	LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Silent_p.S1047S|LAMA3_ENST00000269217.6_Silent_p.S1103S|LAMA3_ENST00000399516.3_Silent_p.S2656S	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2712	Laminin G-like 2.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTGATTTCAGCACATATTATC	0.333000													22	54					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43944804	43944804	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:43944804C>T	ENST00000389420.3	-	2	360	c.361G>A	c.(361-363)Gca>Aca	p.A121T	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.A121T	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	121						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GAGGGCCCTGCGTCGCTCTCC	0.657000													4	5					0	0	1	0	0
ENDOV	284131	broad.mit.edu	37	17	78409945	78409945	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78409945C>T	ENST00000520284.1	+	6	563	c.145C>T	c.(145-147)Cgt>Tgt	p.R49C	ENDOV_ENST00000518907.1_Missense_Mutation_p.R49C|ENDOV_ENST00000520367.1_3'UTR|ENDOV_ENST00000518901.1_3'UTR|ENDOV_ENST00000518137.1_3'UTR|ENDOV_ENST00000517795.1_3'UTR			Q8N8Q3	ENDOV_HUMAN	endonuclease V	0					DNA repair		endodeoxyribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding			endometrium(1)|lung(1)|pancreas(1)|prostate(1)	4						ctttgttgaacgtggtggtga	0.537000								Direct reversal of damage					16	25					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088324	94088324	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:94088324G>T	ENST00000553484.1	+	31	4965	c.4811G>T	c.(4810-4812)aGg>aTg	p.R1604M	UNC79_ENST00000393151.2_Missense_Mutation_p.R1582M|UNC79_ENST00000555664.1_Missense_Mutation_p.R1582M|UNC79_ENST00000256339.4_Missense_Mutation_p.R1405M			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1582						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CCAGAGGTTAGGTTAAACTGT	0.473000													24	55					3.01185e-09	3.19065e-09	1	1	0
RSPH3	83861	broad.mit.edu	37	6	159403613	159403613	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:159403613C>T	ENST00000367069.2	-	5	1236	c.600G>A	c.(598-600)ctG>ctA	p.L200L	RSPH3_ENST00000449822.1_Silent_p.L104L|RSPH3_ENST00000297262.3_Silent_p.L246L|RSPH3_ENST00000252655.1_Silent_p.L342L			Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog (Chlamydomonas)	342										endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|skin(1)|stomach(7)	23		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		GACTGGCCCGCAGGTTAGCCA	0.448000													20	35					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104209063	104209063	+	Translation_Start_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:104209063C>A	ENST00000423488.2	-	0	213				PPP1R13B_ENST00000555391.1_5'UTR|PPP1R13B_ENST00000202556.9_Missense_Mutation_p.E416D			Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B						apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				TGACAGACCCCTCCACGCTCG	0.557000													34	48					5.43694e-19	6.01085e-19	1	1	0
PHLPP1	23239	broad.mit.edu	37	18	60646384	60646384	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:60646384G>A	ENST00000400316.4	+	17	5119	c.3338G>A	c.(3337-3339)gGc>gAc	p.G1113D	PHLPP1_ENST00000262719.5_Missense_Mutation_p.G1625D	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1625					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						AGGGCCAATGGCTCTGTTGCG	0.607000													8	10					0	0	1	0	0
ISLR2	57611	broad.mit.edu	37	15	74427292	74427292	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:74427292G>A	ENST00000361742.3	+	4	2966	c.2197G>A	c.(2197-2199)Gcc>Acc	p.A733T	ISLR2_ENST00000565540.1_Missense_Mutation_p.A733T|ISLR2_ENST00000561975.1_Intron|ISLR2_ENST00000419208.1_Missense_Mutation_p.A733T|ISLR2_ENST00000435464.1_Missense_Mutation_p.A733T|ISLR2_ENST00000445793.1_Missense_Mutation_p.A733T|ISLR2_ENST00000453268.2_Missense_Mutation_p.A733T|ISLR2_ENST00000565159.1_Missense_Mutation_p.A733T	NM_001130136.1|NM_020851.2	NP_001123608.1|NP_065902.1	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing leucine-rich repeat 2	733					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane				breast(3)|endometrium(6)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36						GGTCAACATCGCCCAGGAGAT	0.657000											OREG0023277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	16					0	0	1	0	0
ATAD3C	219293	broad.mit.edu	37	1	1389861	1389861	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1389861C>T	ENST00000378785.2	+	4	1354	c.359C>T	c.(358-360)gCg>gTg	p.A120V		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	120							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GTGCTTGAGGCGCTGCGGCAC	0.662000													4	8					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	581559	581559	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:581559C>T	ENST00000264555.5	+	2	175	c.47C>T	c.(46-48)cCg>cTg	p.P16L	PHRF1_ENST00000413872.2_Missense_Mutation_p.P16L|PHRF1_ENST00000533464.1_Missense_Mutation_p.P16L|PHRF1_ENST00000416188.2_Missense_Mutation_p.P16L	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	16							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						AGCCCAGGGCCGGATGGACAC	0.632000													10	19					0	0	1	0	0
EHD4	30844	broad.mit.edu	37	15	42193242	42193242	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42193242C>T	ENST00000220325.4	-	6	1310	c.1227G>A	c.(1225-1227)acG>acA	p.T409T		NM_139265.3	NP_644670.1	Q9H223	EHD4_HUMAN	EH-domain containing 4	409					endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(7)|ovary(2)|stomach(1)|urinary_tract(1)	20		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		GCACCAGCTGCGTGGGCGTGC	0.657000													18	24					0	0	1	0	0
PPP2R2A	5520	broad.mit.edu	37	8	26227725	26227725	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:26227725A>G	ENST00000380737.3	+	10	1469	c.1140A>G	c.(1138-1140)gaA>gaG	p.E380E	PPP2R2A_ENST00000315985.7_Silent_p.E390E	NM_002717.3	NP_002708.1			protein phosphatase 2, regulatory subunit B, alpha											kidney(1)|large_intestine(2)|ovary(1)	4		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		TAACCCTAGAAGCATCGCGGG	0.423000													4	46					0	0	1	0	0
CYTL1	54360	broad.mit.edu	37	4	5018575	5018575	+	Silent	SNP	C	C	T	rs141557297		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:5018575C>T	ENST00000307746.4	-	3	341	c.315G>A	c.(313-315)tcG>tcA	p.S105S		NM_018659.2	NP_061129.1	Q9NRR1	CYTL1_HUMAN	cytokine-like 1	105					signal transduction	extracellular space|soluble fraction	receptor binding			breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		TCCTGCAGAACGAGTTCATGA	0.493000													28	65					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85384034	85384034	+	Silent	SNP	C	C	T	rs142698933		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:85384034C>T	ENST00000258888.5	+	5	2297	c.2130C>T	c.(2128-2130)tgC>tgT	p.C710C		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	710					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCCAGAATGCGGGGCCCAGA	0.612000													12	19					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84226784	84226784	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:84226784G>A	ENST00000376499.3	-	13	2218	c.1154C>T	c.(1153-1155)aCc>aTc	p.T385I	TLE1_ENST00000464999.1_5'UTR|TLE1_ENST00000376484.1_Missense_Mutation_p.T60I|TLE1_ENST00000376472.1_Missense_Mutation_p.T60I	NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	385	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						GCCTGGGCTGGTCAGCTCGCC	0.672000													21	16					0	0	1	0	0
C10orf82	143379	broad.mit.edu	37	10	118423536	118423536	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118423536G>A	ENST00000588184.1	-	6	625	c.586C>T	c.(586-588)Ccc>Tcc	p.P196S	C10orf82_ENST00000369210.3_3'UTR			Q8WW14	CJ082_HUMAN	chromosome 10 open reading frame 82	196										endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7				all cancers(201;0.0143)		TCTCTCAGGGGCCTTCCAAGG	0.567000													4	5					0	0	1	0	0
PLK2	10769	broad.mit.edu	37	5	57753106	57753106	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:57753106G>A	ENST00000274289.3	-	7	1210	c.910C>T	c.(910-912)Ctg>Ttg	p.L304L	PLK2_ENST00000502671.1_5'UTR	NM_001252226.1|NM_006622.3	NP_001239155.1|NP_006613.2	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	304	Protein kinase.				positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(7)|large_intestine(7)|lung(5)|ovary(3)|prostate(2)|skin(2)	26		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		GCAGGAGCCAGCAATGAGGAC	0.428000													21	16					0	0	1	0	0
DPP9	91039	broad.mit.edu	37	19	4704219	4704219	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4704219C>T	ENST00000262960.9	-	6	801	c.524G>A	c.(523-525)aGc>aAc	p.S175N	DPP9_ENST00000597849.1_Missense_Mutation_p.S175N|DPP9_ENST00000594671.1_Missense_Mutation_p.S146N|DPP9_ENST00000598800.1_Missense_Mutation_p.S146N	NM_139159.4	NP_631898.3	Q86TI2	DPP9_HUMAN	dipeptidyl-peptidase 9	146					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		GCCACTCTCGCTGTGGAAGTC	0.652000													28	36					0	0	1	0	0
MSH6	2956	broad.mit.edu	37	2	48026079	48026079	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:48026079G>A	ENST00000234420.4	+	4	1109	c.957G>A	c.(955-957)acG>acA	p.T319T	MSH6_ENST00000538136.1_Silent_p.T17T|MSH6_ENST00000540021.1_Silent_p.T189T|FBXO11_ENST00000405808.1_Intron	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	319					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGAAGGAAACGCCCTCAGCCA	0.463000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				68	96					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54542540	54542540	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:54542540G>T	ENST00000545554.1	+	7	3346	c.3346G>T	c.(3346-3348)Ggg>Tgg	p.G1116W	UNC13C_ENST00000260323.11_Missense_Mutation_p.G1116W|UNC13C_ENST00000537900.1_Missense_Mutation_p.G1114W			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1116					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGAGTGTGAAGGGCTCCTGTG	0.517000													13	25					0.00010058	0.000103117	1	1	0
ZNF615	284370	broad.mit.edu	37	19	52497638	52497638	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:52497638G>A	ENST00000602063.1	-	6	1040	c.691C>T	c.(691-693)Cct>Tct	p.P231S	ZNF615_ENST00000598071.1_Missense_Mutation_p.P242S|ZNF615_ENST00000594083.1_Missense_Mutation_p.P242S|ZNF615_ENST00000391795.3_Missense_Mutation_p.P236S|ZNF615_ENST00000376716.5_Missense_Mutation_p.P231S			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	231					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CATACATGAGGTTTTTCTCCA	0.408000													56	85					0	0	1	0	0
MAP1LC3C	440738	broad.mit.edu	37	1	242159571	242159571	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:242159571C>A	ENST00000357246.3	-	4	402	c.338G>T	c.(337-339)gGc>gTc	p.G113V		NM_001004343.2	NP_001004343.1	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3 gamma	113					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GTACACGAAGCCATCCTCATC	0.557000													31	63					3.1745e-13	3.44526e-13	1	1	0
ACE	1636	broad.mit.edu	37	17	61574235	61574235	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61574235G>A	ENST00000577647.1	+	13	1903	c.1858G>A	c.(1858-1860)Gcc>Acc	p.A620T	ACE_ENST00000490216.2_Missense_Mutation_p.A620T|ACE_ENST00000428043.1_Intron|ACE_ENST00000421982.2_Missense_Mutation_p.A399T|ACE_ENST00000290866.4_Missense_Mutation_p.A1194T|ACE_ENST00000413513.3_Missense_Mutation_p.A579T|ACE_ENST00000290863.6_Missense_Mutation_p.A620T			P12821	ACE_HUMAN	angiotensin I converting enzyme	1194	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CAACATGAGCGCCTCGGCCAT	0.642000													5	38					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123963874	123963874	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:123963874G>A	ENST00000314393.4	+	3	959	c.124G>A	c.(124-126)Gtg>Atg	p.V42M		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	42						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			ACAGCCTGACGTGGCCAAGGA	0.483000													6	8					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27818816	27818816	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27818816G>A	ENST00000261716.3	+	10	1283	c.764G>A	c.(763-765)cGc>cAc	p.R255H	TAOK1_ENST00000536202.1_Missense_Mutation_p.R255H	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	255	Protein kinase.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			GATTATTTTCGCAACTTTGTA	0.333000													51	111					0	0	1	0	0
TNFRSF13B	23495	broad.mit.edu	37	17	16855889	16855889	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:16855889C>A	ENST00000261652.2	-	2	82	c.70G>T	c.(70-72)Ggc>Tgc	p.G24C	TNFRSF13B_ENST00000583789.1_Intron|TNFRSF13B_ENST00000437538.2_Intron|TNFRSF13B_ENST00000579315.1_Missense_Mutation_p.G24C|TNFRSF13B_ENST00000581616.2_5'UTR	NM_012452.2	NP_036584.1	O14836	TR13B_HUMAN	tumor necrosis factor receptor superfamily, member 13B	24					cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|skin(1)	16						GTCCACAGGCCCTGTGGAACT	0.612000									IgA Deficiency, Selective				8	16					0.00307968	0.00311927	1	1	0
MAN2B1	4125	broad.mit.edu	37	19	12772078	12772078	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12772078G>A	ENST00000456935.2	-	7	1062	c.1022C>T	c.(1021-1023)gCg>gTg	p.A341V	MAN2B1_ENST00000221363.4_Missense_Mutation_p.A341V	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	341					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						ACTGACCTGCGCATTTACCAG	0.532000													25	27					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74286133	74286133	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74286133C>T	ENST00000262765.5	-	5	3419	c.3240G>A	c.(3238-3240)ctG>ctA	p.L1080L		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1080							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						GCTGCTCCTGCAGTTCAGGAG	0.453000													46	80					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49165679	49165679	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49165679G>A	ENST00000307885.4	-	18	3559	c.2865C>T	c.(2863-2865)gaC>gaT	p.D955D	ADCY6_ENST00000550422.1_Silent_p.D902D|ADCY6_ENST00000357869.3_Silent_p.D902D	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	955					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						GGGCCGCCACGTCCTTGGGCA	0.567000													16	26					0	0	1	0	0
C17orf53	78995	broad.mit.edu	37	17	42226031	42226031	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42226031C>T	ENST00000319977.4	+	3	1097	c.860C>T	c.(859-861)aCc>aTc	p.T287I	C17orf53_ENST00000585683.1_Missense_Mutation_p.T287I|C17orf53_ENST00000245382.6_Missense_Mutation_p.T287I	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53	287										NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GCTAGAGGGACCATTCAGAGC	0.532000													49	61					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127641254	127641254	+	Missense_Mutation	SNP	G	G	A	rs142454731		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:127641254G>A	ENST00000508053.1	-	50	6597	c.5623C>T	c.(5623-5625)Cgc>Tgc	p.R1875C	FBN2_ENST00000262464.4_Missense_Mutation_p.R1875C			P35556	FBN2_HUMAN	fibrillin 2	1875	EGF-like 30; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CATTCACAGCGGTAACTACCA	0.453000													39	43					0	0	1	0	0
TFRC	7037	broad.mit.edu	37	3	195796403	195796403	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195796403C>A	ENST00000360110.4	-	7	893	c.724G>T	c.(724-726)Gat>Tat	p.D242Y	TFRC_ENST00000392396.3_Missense_Mutation_p.D242Y|TFRC_ENST00000540528.1_3'UTR|TFRC_ENST00000535031.1_5'UTR|TFRC_ENST00000420415.1_Missense_Mutation_p.D161Y	NM_001128148.1	NP_001121620.1	P02786	TFR1_HUMAN	transferrin receptor	242	PA.				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		TCCTCAAAATCTTTTTTAGTA	0.343000			T	BCL6	NHL								13	16					1.02788e-11	1.10723e-11	1	1	0
KRT10	3858	broad.mit.edu	37	17	38978721	38978721	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38978721G>A	ENST00000269576.5	-	1	126	c.117C>T	c.(115-117)agC>agT	p.S39S	TMEM99_ENST00000496847.1_Intron|TMEM99_ENST00000301665.3_Intron	NM_000421.3	NP_000412.3	P13645	K1C10_HUMAN	keratin 10	39	Gly-rich.|Head.				epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				GGGAGCCTTTGCTGCTAGAAA	0.582000													12	18					0	0	1	0	0
ZNF645	158506	broad.mit.edu	37	X	22291617	22291617	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:22291617G>A	ENST00000323684.1	+	1	553	c.509G>A	c.(508-510)aGa>aAa	p.R170K		NM_152577.3	NP_689790.1	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	170						intracellular	zinc ion binding			cervix(1)|endometrium(4)|large_intestine(8)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	27						ATCCCTAAAAGACTGCAAGAC	0.458000													37	7					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43596380	43596380	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:43596380G>A	ENST00000253803.2	+	0	267																											TCTTTGAAGTGCCTTTTCTGG	0.542000													24	249					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125528119	125528119	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:125528119C>T	ENST00000241305.3	-	9	1376	c.1222G>A	c.(1222-1224)Gtc>Atc	p.V408I	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	408					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		ACCAGGTGGACGATGCGCGCA	0.652000													24	37					0	0	1	0	0
CENPP	401541	broad.mit.edu	37	9	95142122	95142122	+	Missense_Mutation	SNP	G	G	A	rs112987350		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95142122G>A	ENST00000375587.3	+	5	1060	c.545G>A	c.(544-546)cGc>cAc	p.R182H		NM_001012267.1	NP_001012267.1	Q6IPU0	CENPP_HUMAN	centromere protein P	182					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm		p.R182H(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(1)	16						TATCGTAAGCGCACGTTTAAA	0.343000													20	33					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16818191	16818191	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:16818191G>A	ENST00000513610.1	-	3	660	c.206C>T	c.(205-207)gCg>gTg	p.A69V	MYO10_ENST00000507288.1_Missense_Mutation_p.A69V	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	69	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						TGTCAAGGACGCCATGTCATC	0.468000													7	14					0	0	1	0	0
WNT2	7472	broad.mit.edu	37	7	116955208	116955208	+	Missense_Mutation	SNP	G	G	A	rs149362965		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:116955208G>A	ENST00000265441.3	-	3	804	c.505C>T	c.(505-507)Cgc>Tgc	p.R169C	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	169					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity	p.R169C(1)		breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		ACAAATGCGCGGGCAAATTTG	0.478000													35	53					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5235199	5235199	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:5235199C>T	ENST00000274181.7	+	13	2061	c.1923C>T	c.(1921-1923)ccC>ccT	p.P641P	ADAMTS16_ENST00000513709.1_3'UTR	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	641	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						AGAAATGTCCCCGGGACAGTG	0.517000													22	28					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38318135	38318135	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38318135G>A	ENST00000215957.6	+	6	852	c.726G>A	c.(724-726)caG>caA	p.Q242Q		NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	242						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					AGCAGCACCAGCAGCAACTCG	0.662000													8	14					0	0	1	0	0
TRIM46	80128	broad.mit.edu	37	1	155156356	155156356	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155156356G>A	ENST00000368382.1	+	10	2038	c.1901G>A	c.(1900-1902)gGc>gAc	p.G634D	TRIM46_ENST00000392451.2_3'UTR|TRIM46_ENST00000334634.4_Missense_Mutation_p.G657D|TRIM46_ENST00000468878.1_3'UTR|TRIM46_ENST00000545012.1_Missense_Mutation_p.G531D	NM_001256599.1|NM_001256600.1|NM_001256601.1|NM_025058.4	NP_001243528.1|NP_001243529.1|NP_001243530.1|NP_079334.3	Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	657	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTAACCATTGGCATGGGCAAG	0.672000													18	39					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150945295	150945295	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150945295C>T	ENST00000261800.5	-	1	3210	c.3198G>A	c.(3196-3198)gaG>gaA	p.E1066E		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1066	Cadherin 9.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTACTGGAGCTCCCCATCCA	0.622000													7	12					0	0	1	0	0
SIAE	54414	broad.mit.edu	37	11	124530523	124530523	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:124530523C>T	ENST00000263593.3	-	3	578		c.e3+1		SIAE_ENST00000545756.1_Splice_Site			Q9HAT2	SIAE_HUMAN	sialic acid acetylesterase							extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	15	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		CTGCAAATTACCTGTAACACA	0.438000													25	50					0	0	1	0	0
FBXO42	54455	broad.mit.edu	37	1	16577179	16577179	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16577179G>A	ENST00000375592.3	-	10	2356	c.2140C>T	c.(2140-2142)Cga>Tga	p.R714*		NM_018994.1	NP_061867.1	Q6P3S6	FBX42_HUMAN	F-box protein 42	714										autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	26		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		CTCTTTGCTCGTACAAAGTAC	0.398000													41	61					0	0	1	0	0
PCDHA3	0	broad.mit.edu	37	5	140182316	140182316	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140182316G>A	ENST00000522353.2	+	1	1534	c.1534G>A	c.(1534-1536)Gcg>Acg	p.A512T	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.A512T|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCGGTACACGCGGAGAGCGG	0.701000													46	52					0	0	1	0	0
FANCD2OS	115795	broad.mit.edu	37	3	10146209	10146209	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:10146209T>C	ENST00000450660.2	-	2	466	c.250A>G	c.(250-252)Aac>Gac	p.N84D	FANCD2OS_ENST00000524279.1_Missense_Mutation_p.N84D	NM_001164839.1	NP_001158311.1			FANCD2 opposite strand																		AGTCCTTTGTTGTTCATCGTG	0.542000													37	28					0	0	1	0	0
GOLPH3	64083	broad.mit.edu	37	5	32135758	32135758	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:32135758A>G	ENST00000265070.6	-	3	707	c.392T>C	c.(391-393)gTt>gCt	p.V131A	GOLPH3_ENST00000512668.1_5'UTR	NM_022130.3	NP_071413.1	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3 (coat-protein)	131					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11						ATCAAGAAGAACATCCCCTGT	0.398000													22	49					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13168390	13168390	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:13168390G>A	ENST00000319217.7	-	22	3476	c.3229C>T	c.(3229-3231)Cat>Tat	p.H1077Y	MPDZ_ENST00000541718.1_Missense_Mutation_p.H1077Y|MPDZ_ENST00000381022.2_Missense_Mutation_p.H1077Y|MPDZ_ENST00000381015.4_Missense_Mutation_p.H1077Y|MPDZ_ENST00000536827.1_Missense_Mutation_p.H1077Y|MPDZ_ENST00000447879.1_Missense_Mutation_p.H1077Y|MPDZ_ENST00000546205.1_Missense_Mutation_p.H1077Y	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1077	PDZ 6.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		ATGAGAGAATGTCTTCTCAAC	0.408000													61	84					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20871919	20871919	+	Missense_Mutation	SNP	C	C	T	rs145795987	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:20871919C>T	ENST00000262715.5	-	6	1197	c.1157G>A	c.(1156-1158)cGg>cAg	p.R386Q	TEP1_ENST00000556935.1_Intron	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	386	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TCTCTTGGCCCGGTGCTTCCG	0.637000													28	42					0	0	1	0	0
SPOCK1	6695	broad.mit.edu	37	5	136324289	136324289	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:136324289G>A	ENST00000394945.1	-	8	919	c.750C>T	c.(748-750)ggC>ggT	p.G250G	SPOCK1_ENST00000509978.1_5'UTR|SPOCK1_ENST00000282223.7_Silent_p.G250G	NM_004598.3	NP_004589.1	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	250					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGAACATCCAGCCCAGGGAGT	0.512000													5	23					0	0	1	0	0
RECK	8434	broad.mit.edu	37	9	36087701	36087701	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:36087701C>T	ENST00000377966.3	+	9	1214	c.648C>T	c.(646-648)tgC>tgT	p.C216C		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	216	5 X Knot repeats.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GTTTATATTGCTGTGACAGAG	0.373000													17	28					0	0	1	0	0
HEATR4	399671	broad.mit.edu	37	14	73985771	73985771	+	Missense_Mutation	SNP	G	G	T	rs141181710		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:73985771G>T	ENST00000553558.1	-	5	1487	c.1166C>A	c.(1165-1167)cCt>cAt	p.P389H	HEATR4_ENST00000560393.1_Missense_Mutation_p.P342H|RP3-414A15.11_ENST00000553394.1_RNA|HEATR4_ENST00000334988.2_Missense_Mutation_p.P389H	NM_001220484.1	NP_001207413.1			HEAT repeat containing 4											breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TGGAGTTTCAGGGAAGACCTT	0.473000													27	36					2.48779e-11	2.67617e-11	1	1	0
A1CF	29974	broad.mit.edu	37	10	52587968	52587968	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:52587968T>C	ENST00000395489.2	-	9	1067	c.671A>G	c.(670-672)aAa>aGa	p.K224R	A1CF_ENST00000374001.1_Missense_Mutation_p.K231R|A1CF_ENST00000373995.3_Missense_Mutation_p.K239R|A1CF_ENST00000373993.1_Missense_Mutation_p.K231R|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000395495.1_Intron|A1CF_ENST00000373997.3_Missense_Mutation_p.K231R|A1CF_ENST00000282641.2_Missense_Mutation_p.K231R	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	231					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						ATATAGGATTTTCACTGAAGA	0.363000													6	81					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48514664	48514664	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:48514664G>A	ENST00000537810.1	-	57	8583	c.7979C>T	c.(7978-7980)aCg>aTg	p.T2660M	FRYL_ENST00000507873.2_Missense_Mutation_p.T56M|FRYL_ENST00000264319.7_Missense_Mutation_p.T56M|FRYL_ENST00000503238.1_Missense_Mutation_p.T2660M|FRYL_ENST00000358350.4_Missense_Mutation_p.T2660M			O94915	FRYL_HUMAN	FRY-like	2660					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						CAGAGGCGACGTCTGTACTTC	0.443000													15	24					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15733025	15733025	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:15733025C>A	ENST00000281171.4	+	21	3303	c.2973C>A	c.(2971-2973)gaC>gaA	p.D991E	PTPRO_ENST00000348962.2_Missense_Mutation_p.D963E|PTPRO_ENST00000445537.2_Missense_Mutation_p.D180E|PTPRO_ENST00000544244.1_Missense_Mutation_p.D152E|PTPRO_ENST00000542557.1_Missense_Mutation_p.D152E|PTPRO_ENST00000442921.2_Missense_Mutation_p.D180E	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	991	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				AAGGTGCAGACTACATCAATG	0.388000													17	22					1.96292e-10	2.09789e-10	1	1	0
LAMB2	3913	broad.mit.edu	37	3	49169075	49169075	+	Missense_Mutation	SNP	C	C	T	rs1131785		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49169075C>T	ENST00000418109.1	-	6	705	c.541G>A	c.(541-543)Gac>Aac	p.D181N	LAMB2_ENST00000305544.4_Missense_Mutation_p.D181N	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	181	Laminin N-terminal.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCCCCACAGTCATAGGAGAAA	0.577000													18	41					0	0	1	0	0
PACRGL	133015	broad.mit.edu	37	4	20715073	20715073	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:20715073G>A	ENST00000360916.5	+	7	911	c.520G>A	c.(520-522)Gtg>Atg	p.V174M	PACRGL_ENST00000503585.1_Missense_Mutation_p.V174M|PACRGL_ENST00000502938.1_Intron|PACRGL_ENST00000507634.1_Missense_Mutation_p.V174M|PACRGL_ENST00000538990.1_Missense_Mutation_p.V76M|PACRGL_ENST00000502374.1_Missense_Mutation_p.V121M|PACRGL_ENST00000444671.2_Missense_Mutation_p.V76M|PACRGL_ENST00000513459.1_Missense_Mutation_p.V121M|PACRGL_ENST00000295290.8_Missense_Mutation_p.V174M	NM_145048.3	NP_659485.1	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like	174							binding			endometrium(2)|lung(7)|prostate(1)	10						GGATGATGAAGTGTTTGAAAG	0.428000													18	24					0	0	1	0	0
XPO4	64328	broad.mit.edu	37	13	21396280	21396280	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:21396280G>T	ENST00000400602.2	-	8	1024	c.989C>A	c.(988-990)aCt>aAt	p.T330N	XPO4_ENST00000255305.6_Missense_Mutation_p.T330N	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	330					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		CCCATTGATAGTATTCAGTAA	0.403000													28	31					5.77227e-19	6.37883e-19	1	1	0
CHTF8	54921	broad.mit.edu	37	16	69154482	69154482	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:69154482G>A	ENST00000448552.2	-	4	333	c.212C>T	c.(211-213)gCa>gTa	p.A71V	CHTF8_ENST00000518041.1_Intron|CHTF8_ENST00000306585.6_5'UTR|CHTF8_ENST00000519520.1_3'UTR|CHTF8_ENST00000523421.1_Intron|CHTF8_ENST00000520529.1_3'UTR|CHTF8_ENST00000398235.2_Missense_Mutation_p.A71V|CHTF8_ENST00000522091.1_3'UTR	NM_001039690.3|NM_001040146.3	NP_001034779.1|NP_001035236.1	P0CG13	CTF8_HUMAN	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)	71					cell cycle|DNA replication	nucleus	DNA binding										GACAAGGACTGCAAAAGGTTT	0.517000													29	41					0	0	1	0	0
UPF2	26019	broad.mit.edu	37	10	12001315	12001315	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:12001315G>A	ENST00000356352.2	-	11	2698	c.2225C>T	c.(2224-2226)gCg>gTg	p.A742V	UPF2_ENST00000357604.5_Missense_Mutation_p.A742V|UPF2_ENST00000397053.2_Missense_Mutation_p.A742V			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	742	MIF4G 2.|Sufficient for interaction with UPF3A and UPF3B.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				GACGTATCTCGCATCAAGATG	0.393000													31	56					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26689533	26689533	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26689533C>T	ENST00000436292.1	-	5	1247	c.1127G>A	c.(1126-1128)cGg>cAg	p.R376Q	ZNF683_ENST00000374204.1_Missense_Mutation_p.R376Q|ZNF683_ENST00000349618.3_Missense_Mutation_p.R376Q|ZNF683_ENST00000403843.1_Missense_Mutation_p.R376Q			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	376					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		CTTGTGGGGCCGCTCCCCAGT	0.592000													4	8					0	0	1	0	0
GLYCTK	132158	broad.mit.edu	37	3	52325023	52325023	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52325023C>T	ENST00000354773.4	+	3	521	c.425C>T	c.(424-426)gCg>gTg	p.A142V	GLYCTK_ENST00000471180.1_Missense_Mutation_p.A15V|GLYCTK_ENST00000436784.2_Missense_Mutation_p.A142V|GLYCTK_ENST00000305690.8_Missense_Mutation_p.A142V|GLYCTK_ENST00000461183.1_Missense_Mutation_p.A58V|GLYCTK-AS1_ENST00000493616.1_RNA|GLYCTK_ENST00000477382.1_Missense_Mutation_p.A142V|GLYCTK_ENST00000473032.1_Missense_Mutation_p.A142V	NM_001144951.1	NP_001138423.1	Q8IVS8	GLCTK_HUMAN	glycerate kinase	142					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		TTCGAGGGTGCGGAGGACAAC	0.627000													8	15					0	0	1	0	0
GALNT12	79695	broad.mit.edu	37	9	101597550	101597550	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:101597550G>T	ENST00000375011.3	+	5	937	c.937G>T	c.(937-939)Ggg>Tgg	p.G313W		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	313	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				AATGGCTGGTGGGCTGTTTGC	0.418000													39	80					4.32679e-17	4.75887e-17	1	1	0
FBXO34	55030	broad.mit.edu	37	14	55818976	55818976	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:55818976G>A	ENST00000313833.4	+	2	2113	c.1868G>A	c.(1867-1869)cGa>cAa	p.R623Q	FBXO34_ENST00000440021.1_Missense_Mutation_p.R623Q	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	623	F-box.									breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						CGCTGGGTTCGAGATCCACGC	0.478000													16	38					0	0	1	0	0
ZNF214	0	broad.mit.edu	37	11	7022150	7022150	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7022150C>T	ENST00000278314.4	-	3	1079	c.764G>A	c.(763-765)tGc>tAc	p.C255Y	ZNF214_ENST00000536068.1_Missense_Mutation_p.C255Y	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		CTGAGAGAAGCATGCTTTACA	0.398000													30	66					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36358239	36358239	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:36358239C>T	ENST00000373204.4	+	3	504	c.291C>T	c.(289-291)aaC>aaT	p.N97N	AGO1_ENST00000373206.1_Silent_p.N22N	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GAAAGAAGAACATTTACACTG	0.517000													12	24					0	0	1	0	0
PCM1	5108	broad.mit.edu	37	8	17797628	17797628	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:17797628G>A	ENST00000518537.1	+	7	1141	c.861G>A	c.(859-861)tcG>tcA	p.S287S	PCM1_ENST00000325083.8_Intron|PCM1_ENST00000519253.1_Intron|PCM1_ENST00000524226.1_Intron			Q15154	PCM1_HUMAN	pericentriolar material 1	264					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		AGAGCACATCGCTAAACATAG	0.413000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								5	3					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46628468	46628468	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:46628468C>T	ENST00000470495.1	-	2	1971	c.524G>A	c.(523-525)gGc>gAc	p.G175D	HOXB3_ENST00000490677.1_Missense_Mutation_p.G41D|HOXB-AS1_ENST00000435312.1_RNA|HOXB3_ENST00000498678.1_Missense_Mutation_p.G175D|HOXB3_ENST00000311626.4_Missense_Mutation_p.G175D|HOXB3_ENST00000476342.1_Missense_Mutation_p.G175D|HOXB3_ENST00000489475.1_Missense_Mutation_p.G102D|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Missense_Mutation_p.G43D|HOXB3_ENST00000472863.1_Missense_Mutation_p.G102D|HOXB-AS1_ENST00000502764.2_RNA|HOXB3_ENST00000485909.2_Missense_Mutation_p.G43D			P14651	HXB3_HUMAN	homeobox B3	175	Gly-rich.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						CCCTCCCccgccgccgccgcc	0.771000													19	19					0	0	1	0	0
RP11-14N7.2	0	broad.mit.edu	37	1	148932814	148932814	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:148932814G>A	ENST00000539543.1	+	0	70					NR_027355.1																						AAGCTAGCCCGCCAGGCCTCC	0.602000													6	94					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99141223	99141223	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99141223G>A	ENST00000370992.4	-	12	1449	c.1338C>T	c.(1336-1338)tgC>tgT	p.C446C	RRP12_ENST00000536831.1_Silent_p.C164C|RRP12_ENST00000414986.1_Silent_p.C385C|RRP12_ENST00000315563.6_Silent_p.C346C	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	446						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GGGGAGCCACGCATTCCTTCA	0.612000													5	12					0	0	1	0	0
SRSF12	135295	broad.mit.edu	37	6	89814883	89814883	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:89814883C>T	ENST00000452027.2	-	4	564	c.371G>A	c.(370-372)aGt>aAt	p.S124N		NM_080743.4	NP_542781.3	Q8WXF0	SRS12_HUMAN	serine/arginine-rich splicing factor 12	124	Arg/Ser-rich (RS domain).				assembly of spliceosomal tri-snRNP|cytoplasmic transport|negative regulation of nuclear mRNA splicing, via spliceosome|nuclear mRNA 5'-splice site recognition|regulation of alternative nuclear mRNA splicing, via spliceosome	nucleoplasm	nucleotide binding|RNA binding|RS domain binding|unfolded protein binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)	8						CCATGAAGAACTTCTACTTCG	0.418000													14	8					0	0	1	0	0
C5orf51	285636	broad.mit.edu	37	5	41917210	41917210	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:41917210A>C	ENST00000381647.2	+	6	713	c.694A>C	c.(694-696)Aat>Cat	p.N232H		NM_175921.4	NP_787117.3	A6NDU8	CE051_HUMAN	chromosome 5 open reading frame 51	232										endometrium(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						GCAACCAGAAAATCATGAAGT	0.418000													30	60					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39883713	39883713	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:39883713C>T	ENST00000260356.5	+	16	2586	c.2421C>T	c.(2419-2421)ctC>ctT	p.L807L		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	807					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CAGGTATCCTCAATGAACGGG	0.478000													11	16					0	0	1	0	0
ABI1	10006	broad.mit.edu	37	10	27048050	27048050	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:27048050G>A	ENST00000355394.4	-	9	1245	c.1022C>T	c.(1021-1023)aCt>aTt	p.T341I	ABI1_ENST00000536334.1_Intron|ABI1_ENST00000490841.2_Intron|ABI1_ENST00000376170.4_Missense_Mutation_p.T312I|ABI1_ENST00000376134.3_Missense_Mutation_p.T314I|ABI1_ENST00000359188.4_Missense_Mutation_p.T312I|ABI1_ENST00000376138.3_Missense_Mutation_p.T313I|ABI1_ENST00000376139.2_Missense_Mutation_p.T308I|ABI1_ENST00000346832.5_Missense_Mutation_p.T357I|ABI1_ENST00000376137.4_Intron|ABI1_ENST00000376160.1_Missense_Mutation_p.T307I|ABI1_ENST00000376142.2_Missense_Mutation_p.T340I|ABI1_ENST00000376166.1_Missense_Mutation_p.T307I|ABI1_ENST00000376140.3_Missense_Mutation_p.T313I			Q8IZP0	ABI1_HUMAN	abl-interactor 1	340	Pro-rich.				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AAATTGAGCAGTCACAGAGGG	0.463000													29	29					0	0	1	0	0
AHCYL1	10768	broad.mit.edu	37	1	110561184	110561184	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110561184G>A	ENST00000369799.5	+	13	1596	c.1229G>A	c.(1228-1230)cGc>cAc	p.R410H	AHCYL1_ENST00000393614.4_Missense_Mutation_p.R363H|AHCYL1_ENST00000359172.3_Missense_Mutation_p.R363H	NM_001242673.1|NM_001242674.1|NM_006621.5	NP_001229602.1|NP_001229603.1|NP_006612.2	O43865	SAHH2_HUMAN	adenosylhomocysteinase-like 1	410	NAD binding (By similarity).				one-carbon metabolic process	endoplasmic reticulum	adenosylhomocysteinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)	18		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0259)|Colorectal(144;0.123)|all cancers(265;0.134)|Epithelial(280;0.141)|LUSC - Lung squamous cell carcinoma(189;0.143)		ACCAGCCTCCGCACTCCGGAG	0.502000													10	15					0	0	1	0	0
PARS2	25973	broad.mit.edu	37	1	55224719	55224719	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55224719C>T	ENST00000371279.3	-	2	198	c.116G>A	c.(115-117)cGc>cAc	p.R39H		NM_152268.3	NP_689481.2	Q7L3T8	SYPM_HUMAN	prolyl-tRNA synthetase 2, mitochondrial (putative)	39					prolyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|proline-tRNA ligase activity			breast(1)|endometrium(3)|kidney(2)|lung(4)|ovary(2)|prostate(2)|skin(1)	15					L-Proline(DB00172)	CAGCAGCAGGCGCCGCCCTCT	0.607000													7	11					0	0	1	0	0
PDXK	8566	broad.mit.edu	37	21	45172433	45172433	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:45172433C>T	ENST00000291565.4	+	8	728	c.545C>T	c.(544-546)aCc>aTc	p.T182I	PDXK_ENST00000467908.1_Missense_Mutation_p.T142I|PDXK_ENST00000468090.1_Missense_Mutation_p.T154I	NM_003681.4	NP_003672.1	O00764	PDXK_HUMAN	pyridoxal (pyridoxine, vitamin B6) kinase	182					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	GGCCCCGACACCGTGGTCATC	0.642000													15	6					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145311109	145311109	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145311109G>A	ENST00000342960.5	+	13	1843	c.1808G>A	c.(1807-1809)cGg>cAg	p.R603Q	NBPF10_ENST00000369339.2_Missense_Mutation_p.R332Q|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Missense_Mutation_p.R332Q	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	603										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCAGGACATCGGTGGGATCAA	0.448000													34	430					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120594309	120594309	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:120594309C>T	ENST00000300648.6	-	28	3280	c.3268G>A	c.(3268-3270)Gcc>Acc	p.A1090T		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1090					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GACTGCAAGGCACAGAGCAGC	0.607000													5	6					0	0	1	0	0
DROSHA	29102	broad.mit.edu	37	5	31435893	31435893	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:31435893C>T	ENST00000511367.2	-	24	3265	c.3021G>A	c.(3019-3021)caG>caA	p.Q1007Q	DROSHA_ENST00000344624.3_Silent_p.Q1007Q|DROSHA_ENST00000513349.1_Silent_p.Q970Q|DROSHA_ENST00000442743.1_Silent_p.Q970Q	NM_013235.4	NP_037367.3	Q9NRR4	RNC_HUMAN	drosha, ribonuclease type III	1007	Necessary for interaction with DGCR8 and pri-miRNA processing activity.|RNase III 1.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(19)|lung(33)|ovary(2)|skin(1)	66						TGGCAAGGTGCTGATTCTGAA	0.403000													14	29					0	0	1	0	0
KBTBD13	390594	broad.mit.edu	37	15	65370349	65370349	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:65370349G>A	ENST00000432196.2	+	1	1196	c.1196G>A	c.(1195-1197)cGc>cAc	p.R399H		NM_001101362.2	NP_001094832.1	C9JR72	KBTBD_HUMAN	kelch repeat and BTB (POZ) domain containing 13	399						cytoplasm				lung(1)|prostate(1)|skin(1)	3						GCCGTGGTGCGCGGTGACACC	0.672000													4	13					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10933852	10933852	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:10933852C>A	ENST00000298232.7	-	16	1340	c.973_splice	c.e16+1	p.D325_splice	TPTE_ENST00000361285.4_Splice_Site_p.D343_splice|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Splice_Site_p.D305_splice	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	343	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATGTTATTACCTGTGCCTCCT	0.323000													28	131					1.80694e-10	1.9322e-10	1	1	0
ZNF221	7638	broad.mit.edu	37	19	44470941	44470941	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44470941G>T	ENST00000251269.5	+	6	1615	c.1287G>T	c.(1285-1287)aaG>aaT	p.K429N	ZNF221_ENST00000587682.1_Missense_Mutation_p.K429N|ZNF221_ENST00000592350.1_Missense_Mutation_p.K429N	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	429					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				AATGTGGGAAGGGATTTTATA	0.418000													24	33					1.85244e-09	1.96811e-09	1	1	0
TAOK3	51347	broad.mit.edu	37	12	118639201	118639201	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:118639201G>T	ENST00000392533.3	-	12	1377	c.887C>A	c.(886-888)gCa>gAa	p.A296E	TAOK3_ENST00000419821.2_Missense_Mutation_p.A296E	NM_016281.3	NP_057365.3	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	296					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)|skin(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCACGAACTGCATCTTTTGT	0.433000													37	31					6.90743e-12	7.45315e-12	1	1	0
AEN	64782	broad.mit.edu	37	15	89172628	89172628	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:89172628G>A	ENST00000332810.3	+	3	863	c.712G>A	c.(712-714)Gcc>Acc	p.A238T	AEN_ENST00000379231.3_Missense_Mutation_p.A238T	NM_022767.3	NP_073604.3	Q8WTP8	AEN_HUMAN	apoptosis enhancing nuclease	238	Exonuclease.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding			NS(1)|kidney(1)|large_intestine(1)|lung(4)	7						AAAGGACCTGGCCCTGCAGCT	0.652000													7	48					0	0	1	0	0
PDE5A	8654	broad.mit.edu	37	4	120442131	120442131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:120442131C>T	ENST00000354960.3	-	13	2183	c.1864G>A	c.(1864-1866)Gct>Act	p.A622T	RP11-33B1.1_ENST00000498873.1_RNA|PDE5A_ENST00000394439.1_Missense_Mutation_p.A570T|PDE5A_ENST00000264805.5_Missense_Mutation_p.A580T	NM_001083.3	NP_001074.2	O76074	PDE5A_HUMAN	phosphodiesterase 5A, cGMP-specific	622	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding			breast(4)|endometrium(2)|kidney(3)|large_intestine(8)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	27					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	ATGCACTGAGCTGTATTAAAG	0.328000													8	92					0	0	1	0	0
LSR	51599	broad.mit.edu	37	19	35741376	35741376	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35741376G>A	ENST00000602122.1	+	2	899	c.412G>A	c.(412-414)Gat>Aat	p.D138N	LSR_ENST00000354900.3_Missense_Mutation_p.D138N|LSR_ENST00000347609.4_Missense_Mutation_p.D101N|LSR_ENST00000427250.1_Missense_Mutation_p.D90N|LSR_ENST00000361790.3_Missense_Mutation_p.D138N|LSR_ENST00000360798.3_Missense_Mutation_p.D138N|LSR_ENST00000597933.1_3'UTR			Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	138	Ig-like V-type.				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCGCATCGCCGATGCCTTCTC	0.632000													22	37					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36489878	36489878	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36489878G>A	ENST00000342292.4	-	9	1848	c.1828C>T	c.(1828-1830)Ctc>Ttc	p.L610F		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	610						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.L610F(1)		breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AAGAAGAAGAGGAGGAGGGTC	0.612000											OREG0024354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	26					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171085413	171085413	+	Missense_Mutation	SNP	C	C	T	rs149551557		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:171085413C>T	ENST00000367755.4	+	8	1360	c.1249C>T	c.(1249-1251)Cgc>Tgc	p.R417C	FMO3_ENST00000538429.1_Missense_Mutation_p.R354C|FMO3_ENST00000542847.1_Missense_Mutation_p.R397C|FMO3_ENST00000392085.2_Missense_Mutation_p.R417C	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	417					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGAGAAAAAGCGCAAATGGTA	0.328000													30	82					0	0	1	0	0
GFOD2	81577	broad.mit.edu	37	16	67719373	67719373	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67719373G>A	ENST00000268797.7	-	2	591	c.246C>T	c.(244-246)tcC>tcT	p.S82S	GFOD2_ENST00000602377.1_Intron	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	82						proteinaceous extracellular matrix	binding|oxidoreductase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		GAGCCTTCACGGATATCTGCC	0.592000													8	8					0	0	1	0	0
ZNF830	91603	broad.mit.edu	37	17	33289429	33289429	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:33289429A>T	ENST00000361952.3	+	1	881	c.844A>T	c.(844-846)Agg>Tgg	p.R282W		NM_052857.3	NP_443089.3	Q96NB3	ZN830_HUMAN	zinc finger protein 830	282					cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(1)|liver(2)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Ovarian(249;0.17)				AAAAGCCATGAGGCAGGTCAA	0.483000													20	25					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45944611	45944611	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:45944611C>T	ENST00000348697.2	+	13	1707	c.1560C>T	c.(1558-1560)ggC>ggT	p.G520G	FBLN1_ENST00000402984.3_Silent_p.G558G|FBLN1_ENST00000327858.6_Silent_p.G520G|FBLN1_ENST00000262722.7_Silent_p.G520G|FBLN1_ENST00000476366.1_Intron|FBLN1_ENST00000340923.5_Silent_p.G520G|FBLN1_ENST00000442170.2_Silent_p.G520G			P23142	FBLN1_HUMAN	fibulin 1	520	EGF-like 8; calcium-binding.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCCCCAATGGCCGCAACTGCC	0.672000													5	12					0	0	1	0	0
LAMP1	3916	broad.mit.edu	37	13	113976601	113976601	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113976601G>T	ENST00000332556.4	+	9	1313	c.1119G>T	c.(1117-1119)gaG>gaT	p.E373D	LAMP1_ENST00000471046.1_3'UTR|LAMP1_ENST00000397181.3_Missense_Mutation_p.E320D	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	373	Second lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			TGGCAGTGGAGGAGTGTCTGC	0.627000													18	26					5.35267e-07	5.59292e-07	1	1	0
LIPC	3990	broad.mit.edu	37	15	58834094	58834094	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:58834094C>T	ENST00000414170.3	+	4	671	c.384C>T	c.(382-384)gaC>gaT	p.D128D	LIPC_ENST00000433326.2_Intron|LIPC_ENST00000356113.6_Silent_p.D128D|LIPC_ENST00000299022.5_Silent_p.D128D			P11150	LIPC_HUMAN	lipase, hepatic	128					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TGGCCCACGACCACTACACCA	0.642000													7	18					0	0	1	0	0
PAX3	5077	broad.mit.edu	37	2	223159003	223159003	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:223159003T>C	ENST00000350526.4	-	4	605	c.469A>G	c.(469-471)Atc>Gtc	p.I157V	PAX3_ENST00000258387.5_Missense_Mutation_p.I157V|PAX3_ENST00000409828.3_Missense_Mutation_p.I157V|PAX3_ENST00000409551.3_Missense_Mutation_p.I156V|PAX3_ENST00000392070.2_Missense_Mutation_p.I157V|PAX3_ENST00000336840.6_Missense_Mutation_p.I157V|PAX3_ENST00000392069.2_Missense_Mutation_p.I157V|PAX3_ENST00000344493.4_Missense_Mutation_p.I157V	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	157	Paired.				apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTTCTCAGGATGCGGCTGATG	0.597000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						5	30					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49753836	49753836	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49753836C>T	ENST00000327697.6	+	35	3570	c.3426C>T	c.(3424-3426)agC>agT	p.S1142S	RNF123_ENST00000433785.1_Silent_p.S254S	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	1142						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GCCTAGAGAGCGTGGACCACT	0.632000													81	103					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3140843	3140843	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3140843C>T	ENST00000263650.7	-	7	784	c.625G>A	c.(625-627)Gtg>Atg	p.V209M	OSBPL5_ENST00000348039.5_Missense_Mutation_p.V141M|OSBPL5_ENST00000525498.1_Missense_Mutation_p.V120M|OSBPL5_ENST00000542243.1_Intron|OSBPL5_ENST00000389989.3_Missense_Mutation_p.V141M	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	209	PH.				cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		ATGGAGCCCACGCTCTCACCT	0.627000													15	28					0	0	1	0	0
TTC7B	145567	broad.mit.edu	37	14	91044611	91044611	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:91044611C>T	ENST00000357056.2	-	20	2321	c.2200G>A	c.(2200-2202)Gcc>Acc	p.A734T	TTC7B_ENST00000554654.1_5'UTR|TTC7B_ENST00000328459.6_Missense_Mutation_p.A717T			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	717							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				TGGGTACAGGCTGTGGCTTCT	0.597000													6	20					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16945454	16945454	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16945454G>A	ENST00000412962.1	-	0	2065																											CCCTACGACGGCAGGCCTACC	0.642000													9	63					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12397436	12397436	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:12397436A>G	ENST00000261349.4	-	2	285	c.209T>C	c.(208-210)gTc>gCc	p.V70A	LRP6_ENST00000543091.1_Missense_Mutation_p.V70A	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	70	Beta-propeller 1.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				TTCTTCGCTGACATCACTCCA	0.443000													24	27					0	0	1	0	0
ZNF37A	7587	broad.mit.edu	37	10	38406981	38406981	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:38406981G>A	ENST00000351773.3	+	8	1732	c.902G>A	c.(901-903)tGt>tAt	p.C301Y	ZNF37A_ENST00000361085.4_Missense_Mutation_p.C301Y	NM_001007094.2	NP_001007095.1	P17032	ZN37A_HUMAN	zinc finger protein 37A	301						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						CCCTATGAATGTCATGAATGT	0.408000													41	58					0	0	1	0	0
RP11-848G14.2	0	broad.mit.edu	37	5	68902961	68902961	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:68902961G>T	ENST00000510264.2	+	0	36																											GACGGACAGAGCATTTGTTCT	0.393000													11	107					5.35356e-11	5.74024e-11	1	1	0
SOBP	55084	broad.mit.edu	37	6	107854672	107854672	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:107854672T>G	ENST00000317357.5	+	4	1090	c.431T>G	c.(430-432)gTg>gGg	p.V144G		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	144							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GAAGATGATGTGTCAAATGTA	0.418000													24	42					0	0	1	0	0
TIAF1	9220	broad.mit.edu	37	17	27400976	27400976	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27400976G>A	ENST00000359450.6	-	1	4899	c.242C>T	c.(241-243)cCa>cTa	p.P81L	TIAF1_ENST00000408971.2_Missense_Mutation_p.P81L|MYO18A_ENST00000354329.4_3'UTR|MYO18A_ENST00000529578.1_5'UTR|MYO18A_ENST00000527372.1_3'UTR|MYO18A_ENST00000533112.1_3'UTR|MYO18A_ENST00000531253.1_3'UTR	NM_004740.3	NP_004731.2	O95411	TIAF1_HUMAN	TGFB1-induced anti-apoptotic factor 1	81					anti-apoptosis|apoptosis|I-kappaB kinase/NF-kappaB cascade	nucleus				kidney(1)|lung(1)|urinary_tract(1)	3	Lung NSC(42;0.015)		Epithelial(11;1.19e-05)|all cancers(11;6.57e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000153)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TAGTTGGAATGGGTTTACCTT	0.537000													33	56					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143096356	143096356	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:143096356C>T	ENST00000275815.3	-	5	1072	c.986G>A	c.(985-987)tGc>tAc	p.C329Y		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	329	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CTCACCTGTGCATGCCACCTG	0.617000													15	25					0	0	1	0	0
RPN2	6185	broad.mit.edu	37	20	35833290	35833290	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:35833290C>T	ENST00000237530.6	+	6	987	c.676C>T	c.(676-678)Cca>Tca	p.P226S	RPN2_ENST00000373622.5_Missense_Mutation_p.P194S	NM_002951.3	NP_002942.2	P04844	RPN2_HUMAN	ribophorin II	226					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(2)|stomach(1)	24		Myeloproliferative disorder(115;0.00878)				GGGGACTGAGCCATCCATTAA	0.468000													6	55					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36104725	36104725	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:36104725G>T	ENST00000258840.6	-	32	4769	c.4379C>A	c.(4378-4380)gCt>gAt	p.A1460D	RALGAPA1_ENST00000382366.3_Missense_Mutation_p.A1426D|RALGAPA1_ENST00000307138.6_Missense_Mutation_p.A1413D|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.A1413D			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	1413	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGCTCCCGTAGCATGAAATGG	0.363000													4	31					0.00024832	0.000253518	1	1	0
CRHBP	1393	broad.mit.edu	37	5	76259283	76259283	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:76259283C>T	ENST00000274368.4	+	6	1231	c.809C>T	c.(808-810)cCg>cTg	p.P270L	CRHBP_ENST00000514258.1_3'UTR	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	270					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		TTTCATGGCCCGGGTGAGGTA	0.448000													55	87					0	0	1	0	0
CLDN1	9076	broad.mit.edu	37	3	190030679	190030679	+	Missense_Mutation	SNP	C	C	T	rs140846629	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:190030679C>T	ENST00000295522.3	-	2	638	c.370G>A	c.(370-372)Gcg>Acg	p.A124T		NM_021101.4	NP_066924.1	O95832	CLD1_HUMAN	claudin 1	124					calcium-independent cell-cell adhesion|interspecies interaction between organisms	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity			lung(9)	9	all_cancers(143;2.95e-10)|Ovarian(172;0.0512)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.015)		AGAAATATCGCACCCCCAATG	0.458000													28	59					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50532618	50532618	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:50532618G>A	ENST00000374144.3	+	3	2316	c.2028G>A	c.(2026-2028)gtG>gtA	p.V676V	C10orf71_ENST00000323868.4_Silent_p.V676V			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	676										endometrium(1)	1						CCAGATCTGTGTCCCAAGAGA	0.522000													16	24					0	0	1	0	0
CYP2A7	1549	broad.mit.edu	37	19	41386435	41386435	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41386435G>A	ENST00000301146.4	-	3	983	c.442C>T	c.(442-444)Cgc>Tgc	p.R148C	CYP2A7_ENST00000291764.3_Missense_Mutation_p.R97C|CTC-490E21.12_ENST00000601627.1_Intron	NM_000764.2	NP_000755.2	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 7	148						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TCCTGGATGCGCTCCTCGATG	0.662000													9	24					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236902770	236902770	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:236902770C>T	ENST00000366578.4	+	10	1211	c.1045C>T	c.(1045-1047)Cag>Tag	p.Q349*	ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000546208.1_Intron|ACTN2_ENST00000542672.1_Nonsense_Mutation_p.Q349*	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	349					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CAACACGCTGCAGACCAAGCT	0.602000													20	21					0	0	1	0	0
CD226	10666	broad.mit.edu	37	18	67562982	67562982	+	Missense_Mutation	SNP	C	C	T	rs146723371	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:67562982C>T	ENST00000280200.4	-	4	950	c.682G>A	c.(682-684)Gca>Aca	p.A228T	CD226_ENST00000582621.1_Missense_Mutation_p.A228T|CD226_ENST00000577287.1_Missense_Mutation_p.A73T|CD226_ENST00000581982.1_Missense_Mutation_p.A73T	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	228	Ig-like C2-type 2.				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity	p.A228T(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				TTTTCTCCTGCGCTGGCCTGC	0.542000													40	67					0	0	1	0	0
RRAS2	22800	broad.mit.edu	37	11	14303157	14303157	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:14303157C>T	ENST00000545643.1	-	5	849	c.536G>A	c.(535-537)cGg>cAg	p.R179Q	RRAS2_ENST00000526063.1_Missense_Mutation_p.R96Q|RRAS2_ENST00000534746.1_Missense_Mutation_p.R96Q|RRAS2_ENST00000256196.4_Missense_Mutation_p.R173Q|RRAS2_ENST00000537760.1_Missense_Mutation_p.R138Q|RRAS2_ENST00000414023.2_Missense_Mutation_p.R96Q|RRAS2_ENST00000532814.1_Missense_Mutation_p.R96Q|RRAS2_ENST00000529237.1_Missense_Mutation_p.R96Q	NM_012250.5	NP_036382.2	P62070	RRAS2_HUMAN	related RAS viral (r-ras) oncogene homolog 2	173						endoplasmic reticulum|plasma membrane	GTP binding|GTPase activity|protein binding			breast(3)|endometrium(4)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	12				Epithelial(150;0.203)		CCTGATAACCCGGACAAGTTC	0.348000													29	49					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233353643	233353643	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:233353643A>G	ENST00000258229.8	-	12	2926		c.e12+1		PCNXL2_ENST00000488780.2_Splice_Site|PCNXL2_ENST00000430153.1_Splice_Site	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TTGGAAACTTACGTGTATTGG	0.433000													8	15					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180061797	180061797	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:180061797C>T	ENST00000367607.3	+	34	6975	c.6557C>T	c.(6556-6558)tCt>tTt	p.S2186F	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	2186						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						AGGTCTTTATCTGCATATGCA	0.358000													9	16					0	0	1	0	0
TLX2	3196	broad.mit.edu	37	2	74742863	74742863	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74742863G>A	ENST00000233638.7	+	2	827	c.504G>A	c.(502-504)caG>caA	p.Q168Q		NM_016170.4	NP_057254.1	O43763	TLX2_HUMAN	T-cell leukemia homeobox 2	168						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|ovary(1)	2						CCCGCTCACAGGTGCTGGAGT	0.677000													12	19					0	0	1	0	0
CD164	8763	broad.mit.edu	37	6	109699120	109699120	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:109699120G>A	ENST00000368961.5	-	3	494	c.314C>T	c.(313-315)aCg>aTg	p.T105M	CD164_ENST00000275080.7_Missense_Mutation_p.T105M|CD164_ENST00000324953.5_Missense_Mutation_p.T105M|CD164_ENST00000506649.1_5'UTR|CD164_ENST00000310786.4_Missense_Mutation_p.T105M|CD164_ENST00000512821.1_Missense_Mutation_p.T105M|CD164_ENST00000504373.1_Missense_Mutation_p.T71M|CD164_ENST00000413644.2_Missense_Mutation_p.T105M			Q04900	MUC24_HUMAN	CD164 molecule, sialomucin	105	Thr-rich.				hemopoiesis|heterophilic cell-cell adhesion|immune response|muscle organ development|negative regulation of cell adhesion|negative regulation of cell proliferation|signal transduction	endosome membrane|extracellular region|integral to plasma membrane|lysosomal membrane	protein binding			breast(1)|lung(2)	3		all_cancers(87;4.65e-22)|all_epithelial(87;2.54e-20)|all_lung(197;1.6e-05)|Lung NSC(302;2.92e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.0175)		Epithelial(106;7.83e-46)|all cancers(137;1.15e-45)|OV - Ovarian serous cystadenocarcinoma(136;2.89e-26)|BRCA - Breast invasive adenocarcinoma(108;0.00128)|GBM - Glioblastoma multiforme(226;0.16)		GAAGTCTGTCGTGTTCCCCAC	0.473000													27	33					0	0	1	0	0
PLEKHM2	23207	broad.mit.edu	37	1	16046306	16046306	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16046306C>T	ENST00000375799.3	+	6	770	c.543C>T	c.(541-543)cgC>cgT	p.R181R	PLEKHM2_ENST00000375793.2_Silent_p.R181R	NM_015164.2	NP_055979.2	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 2	181	Interaction with KIF5B.				Golgi organization	cytoplasm	kinesin binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TTGAAGACCGCCTTCCCAGCT	0.577000													19	35					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656215	19656215	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19656215G>A	ENST00000586018.1	+	8	2981	c.2879G>A	c.(2878-2880)cGc>cAc	p.R960H	CILP2_ENST00000291495.4_Missense_Mutation_p.R954H			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	954						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						TATATGGTCCGCTCCCACAAC	0.682000													7	15					0	0	1	0	0
GBP7	388646	broad.mit.edu	37	1	89597932	89597932	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:89597932G>A	ENST00000294671.2	-	11	1955	c.1817C>T	c.(1816-1818)gCa>gTa	p.A606V		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	606						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		AGGTAGTGCTGCAATAAATAT	0.378000													23	46					0	0	1	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133930934	133930934	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:133930934C>T	ENST00000298622.4	+	2	627	c.489C>T	c.(487-489)ggC>ggT	p.G163G		NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGCTCAAGGGCGCCAAAAGGC	0.612000													11	25					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3511909	3511909	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:3511909G>A	ENST00000356575.4	-	3	595	c.369C>T	c.(367-369)tgC>tgT	p.C123C		NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	123	EMI.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CACCCGAGAGGCAGCCCTCCT	0.687000													12	26					0	0	1	0	0
BUB1B	701	broad.mit.edu	37	15	40468811	40468811	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40468811C>T	ENST00000287598.6	+	5	713	c.518C>T	c.(517-519)gCg>gTg	p.A173V	BUB1B_ENST00000412359.3_Missense_Mutation_p.A187V|BUB1B_ENST00000560120.1_3'UTR	NM_001211.5	NP_001202.4	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	173	BUB1 N-terminal.|Necessary for interaction with CASC5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		AAAGCAGATGCGATATTTCAG	0.408000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				23	40					0	0	1	0	0
CSTF3	1479	broad.mit.edu	37	11	33118431	33118431	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:33118431G>A	ENST00000323959.4	-	14	1361	c.1222C>T	c.(1222-1224)Cgc>Tgc	p.R408C	TCP11L1_ENST00000324357.9_Intron	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	408					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						ACATGGTGGCGGGTTCTGGTA	0.358000													35	38					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151671538	151671538	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:151671538G>A	ENST00000402676.2	+	4	2252	c.2012G>A	c.(2011-2013)cGc>cAc	p.R671H	AKAP12_ENST00000359755.5_Missense_Mutation_p.R566H|AKAP12_ENST00000253332.1_Missense_Mutation_p.R671H|AKAP12_ENST00000354675.6_Missense_Mutation_p.R573H	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	671					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GAACCAAAGCGCAAGGTGGAT	0.502000													5	30					0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	136030608	136030608	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136030608G>A	ENST00000542690.1	-	6	633	c.353C>T	c.(352-354)gCc>gTc	p.A118V	GBGT1_ENST00000372043.3_Missense_Mutation_p.P106S|GBGT1_ENST00000472281.1_5'UTR|GBGT1_ENST00000372040.3_Missense_Mutation_p.P106S|GBGT1_ENST00000540636.1_Missense_Mutation_p.P89S|GBGT1_ENST00000372038.3_Missense_Mutation_p.A118V			Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	0	N-terminal Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		AGGTTCAGTGGCTGGTAGATG	0.602000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								8	17					0	0	1	0	0
VDR	0	broad.mit.edu	37	12	48251385	48251385	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48251385G>A	ENST00000229022.3	-	6	645	c.364C>T	c.(364-366)Ccc>Tcc	p.P122S	VDR_ENST00000535672.1_Missense_Mutation_p.P90S|VDR_ENST00000395324.2_Missense_Mutation_p.P122S|VDR_ENST00000549336.1_Missense_Mutation_p.P122S|VDR_ENST00000550325.1_Missense_Mutation_p.P172S	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	122	Hinge.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GACAGCTTGGGCCGCAGACTG	0.582000													18	28					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99129371	99129371	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99129371C>T	ENST00000394170.2	+	7	2270	c.2019C>T	c.(2017-2019)taC>taT	p.Y673Y	ZKSCAN5_ENST00000326775.5_Silent_p.Y673Y|ZKSCAN5_ENST00000451158.1_Silent_p.Y673Y	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	673					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TTTTTCAGTACGTTAGCCTAA	0.458000													7	101					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127561615	127561615	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:127561615C>T	ENST00000373580.3	+	4	514	c.514C>T	c.(514-516)Cgc>Tgc	p.R172C		NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	172										endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						GGACAGCGTGCGCCACCTCAG	0.597000													16	18					0	0	1	0	0
KRT31	3881	broad.mit.edu	37	17	39552805	39552805	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39552805C>T	ENST00000251645.2	-	3	507	c.455G>A	c.(454-456)cGg>cAg	p.R152Q		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	152	Coil 1B.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				CACCAGCTGCCGCAGGGACAG	0.567000													20	29					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56092305	56092305	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56092305C>A	ENST00000257880.7	-	8	1405	c.1186G>T	c.(1186-1188)Ggg>Tgg	p.G396W	ITGA7_ENST00000555728.1_Missense_Mutation_p.G396W|ITGA7_ENST00000257879.6_Missense_Mutation_p.G352W|ITGA7_ENST00000553804.1_Missense_Mutation_p.G356W|ITGA7_ENST00000452168.2_Missense_Mutation_p.G259W|ITGA7_ENST00000394229.2_Missense_Mutation_p.G352W|ITGA7_ENST00000394230.2_Missense_Mutation_p.G356W|ITGA7_ENST00000347027.6_Missense_Mutation_p.G352W			Q13683	ITA7_HUMAN	integrin, alpha 7	396					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						ACAGCACCCCCCAGCTCTTCT	0.602000													6	50					0.00198382	0.0020125	1	1	0
BPIFB3	359710	broad.mit.edu	37	20	31652621	31652621	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31652621C>T	ENST00000375494.3	+	8	894	c.894C>T	c.(892-894)ggC>ggT	p.G298G		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	298					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										AGACCAACGGCGCCCTCGACA	0.617000													5	27					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183853014	183853014	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:183853014C>T	ENST00000304685.3	+	7	1271	c.810C>T	c.(808-810)ctC>ctT	p.L270L	RGL1_ENST00000360851.3_Silent_p.L235L|RGL1_ENST00000539189.1_Silent_p.L235L|RGL1_ENST00000536277.1_Silent_p.L233L|RGL1_ENST00000367531.1_Silent_p.L270L	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	235	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						CAGAAGATCTCGTGGCAGAGC	0.507000													9	68					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35807107	35807107	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35807107C>T	ENST00000342694.2	+	17	2862	c.2607C>T	c.(2605-2607)ggC>ggT	p.G869G		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	869	Guanylate cyclase.				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	ACATTGTTGGCTTCACAGCAT	0.557000													21	27					0	0	1	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151130361	151130361	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:151130361G>A	ENST00000367328.1	+	9	1345	c.1033G>A	c.(1033-1035)Gac>Aac	p.D345N	PLEKHG1_ENST00000358517.2_Missense_Mutation_p.D345N	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	345	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		CTTCCTCTTCGACAAGCTGCT	0.557000													18	29					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48685381	48685381	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48685381C>T	ENST00000544264.1	-	21	7317	c.7037G>A	c.(7036-7038)cGt>cAt	p.R2346H	CELSR3_ENST00000164024.4_Missense_Mutation_p.R2341H			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2341					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGGGTAGCGACGGGCCCCCCG	0.632000													27	76					0	0	1	0	0
RNASEL	6041	broad.mit.edu	37	1	182555596	182555596	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:182555596C>T	ENST00000367559.3	-	2	599	c.346G>A	c.(346-348)Gca>Aca	p.A116T	RNASEL_ENST00000539397.1_Missense_Mutation_p.A116T|RNASEL_ENST00000444138.1_Missense_Mutation_p.A116T	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	116					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						TTGACATCTGCTCCTTTAGAA	0.478000													14	18					0	0	1	0	0
DVL2	1856	broad.mit.edu	37	17	7133391	7133391	+	Missense_Mutation	SNP	C	C	T	rs144205338	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7133391C>T	ENST00000005340.5	-	4	776	c.494G>A	c.(493-495)cGc>cAc	p.R165H	DVL2_ENST00000574642.1_5'UTR|DVL2_ENST00000575458.1_Missense_Mutation_p.R159H	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	165					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						GTCTCTCCTGCGAGGCCGCTC	0.642000													17	20					0	0	1	0	0
CCDC91	55297	broad.mit.edu	37	12	28458701	28458701	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:28458701G>T	ENST00000545336.1	+	7	648	c.229G>T	c.(229-231)Gca>Tca	p.A77S	CCDC91_ENST00000381259.1_Missense_Mutation_p.A77S|CCDC91_ENST00000540401.1_3'UTR|CCDC91_ENST00000539107.1_Missense_Mutation_p.A77S|CCDC91_ENST00000381256.1_Missense_Mutation_p.A77S|CCDC91_ENST00000306172.5_Missense_Mutation_p.A47S			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91	77					protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					TACACATGCAGCAAATAGCAT	0.378000													38	55					6.97489e-18	7.68957e-18	1	1	0
STRN	6801	broad.mit.edu	37	2	37078199	37078199	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:37078199G>A	ENST00000263918.4	-	16	2038	c.2030C>T	c.(2029-2031)cCg>cTg	p.P677L	STRN_ENST00000379213.2_Missense_Mutation_p.P628L	NM_003162.3	NP_003153.2	O43815	STRN_HUMAN	striatin, calmodulin binding protein	677				P -> S (in Ref. 1; CAA11560).	dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33		Ovarian(717;0.0129)|all_hematologic(82;0.21)				GATGCTGATCGGAAGAGTAGG	0.303000													16	33					0	0	1	0	0
CYP2A6	1548	broad.mit.edu	37	19	41354570	41354570	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41354570G>A	ENST00000301141.5	-	3	462	c.442C>T	c.(442-444)Cgc>Tgc	p.R148C	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753.3	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	148					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	TCCTGGATGCGCTCCTCGATG	0.692000													6	38					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2752068	2752068	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2752068C>T	ENST00000407112.1	+	6	1196	c.883C>T	c.(883-885)Cat>Tat	p.H295Y	AMZ1_ENST00000312371.4_Silent_p.G351G|AMZ1_ENST00000489665.1_Intron			Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	0							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CCGACTCGGGCATGTGCTGTG	0.701000													9	11					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105503421	105503421	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:105503421G>A	ENST00000276654.5	-	7	2168	c.2060C>T	c.(2059-2061)gCg>gTg	p.A687V	LRP12_ENST00000424843.2_Missense_Mutation_p.A668V|LRP12_ENST00000518375.1_5'UTR	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	687					endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TCCTACTGTCGCTTCTACTGC	0.507000													16	32					0	0	1	0	0
PITRM1	10531	broad.mit.edu	37	10	3208440	3208440	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:3208440C>T	ENST00000380989.2	-	4	437	c.399G>A	c.(397-399)acG>acA	p.T133T	PITRM1_ENST00000224949.4_Silent_p.T133T|PITRM1-AS1_ENST00000598280.1_RNA|PITRM1_ENST00000451104.2_Silent_p.T101T	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	101					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						CGTTCATGAACGTGGAGAGGG	0.483000													33	78					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17491740	17491740	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:17491740T>C	ENST00000302539.4	-	3	445	c.320A>G	c.(319-321)tAc>tGc	p.Y107C	ABCC8_ENST00000389817.3_Missense_Mutation_p.Y107C	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	107					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GGCTGGCATGTACAGGTGCAG	0.537000													4	25					0	0	1	0	0
GP1BA	2811	broad.mit.edu	37	17	4836171	4836171	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4836171C>T	ENST00000329125.5	+	2	347	c.272C>T	c.(271-273)aCg>aTg	p.T91M		NM_000173.5	NP_000164.5	E7ES66	E7ES66_HUMAN	glycoprotein Ib (platelet), alpha polypeptide	91										central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(5)|stomach(1)|urinary_tract(1)	20						GTCGATGGGACGCTGCCAGTG	0.597000													25	16					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74288562	74288562	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74288562C>T	ENST00000262765.5	-	4	1927	c.1748G>A	c.(1747-1749)cGt>cAt	p.R583H		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	583	Gln-rich.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						GACCAAACCACGCTGATGATC	0.537000													14	62					0	0	1	0	0
CD109	135228	broad.mit.edu	37	6	74516566	74516566	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:74516566G>T	ENST00000437994.2	+	25	3391		c.e25-1		CD109_ENST00000287097.5_Splice_Site|CD109_ENST00000422508.2_Splice_Site	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule							anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTTTCATAAAGGTTGTCAGCT	0.343000													12	24					9.05144e-12	9.75833e-12	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105418103	105418103	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105418103C>T	ENST00000333244.5	-	7	3804	c.3685G>A	c.(3685-3687)Gtg>Atg	p.V1229M	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1229						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGGAGCTTCACGTCCACCTGG	0.622000													54	9					0	0	1	0	0
ZBTB8A	653121	broad.mit.edu	37	1	33058588	33058588	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33058588G>T	ENST00000373510.4	+	3	285	c.56G>T	c.(55-57)aGg>aTg	p.R19M	ZBTB8A_ENST00000316459.4_Missense_Mutation_p.R19M|RP1-27O5.3_ENST00000480336.1_3'UTR	NM_001040441.1	NP_001035531.1	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(2)|lung(2)|prostate(1)	7						GAGCAGCGCAGGCAAGATGTA	0.428000													23	32					7.87624e-14	8.57347e-14	1	1	0
CCNF	899	broad.mit.edu	37	16	2498959	2498959	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2498959G>A	ENST00000397066.4	+	11	1286	c.1198G>A	c.(1198-1200)Gcc>Acc	p.A400T		NM_001761.2	NP_001752.2	P41002	CCNF_HUMAN	cyclin F	400	Cyclin N-terminal.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(2)|lung(5)|prostate(4)|skin(1)	20		Ovarian(90;0.17)				GATCGTCTCCGCCTTGGAAGG	0.527000													19	39					0	0	1	0	0
NDUFS2	4720	broad.mit.edu	37	1	161183492	161183492	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161183492C>T	ENST00000392179.4	+	12	1505	c.1266C>T	c.(1264-1266)tgC>tgT	p.C422C	NDUFS2_ENST00000465923.1_3'UTR|NDUFS2_ENST00000367993.3_Silent_p.C422C	NM_001166159.1	NP_001159631.1	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	422					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	18	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	CTTATCGATGCAAGATCAAGG	0.443000													17	102					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89938497	89938497	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:89938497G>A	ENST00000405460.2	+	12	2381	c.2285G>A	c.(2284-2286)cGt>cAt	p.R762H		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	762					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TATACTAGCCGTGACCTAATT	0.398000													28	55					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52552767	52552767	+	Missense_Mutation	SNP	G	G	A	rs148162424		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52552767G>A	ENST00000321725.6	+	48	4992	c.4916G>A	c.(4915-4917)cGc>cAc	p.R1639H		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1639	FAS1 5.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CGTGCGCATCGCCAGCTGGTG	0.692000													8	12					0	0	1	0	0
ZNF876P	0	broad.mit.edu	37	4	247864	247864	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:247864G>A	ENST00000356347.3	+	0	688					NR_027481.1																						AAACATAAGAGAATTCATACT	0.378000													16	20					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233756165	233756165	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:233756165G>A	ENST00000264051.3	-	8	1453	c.1175C>T	c.(1174-1176)gCg>gTg	p.A392V	NGEF_ENST00000539537.1_Missense_Mutation_p.A115V|NGEF_ENST00000373552.4_Missense_Mutation_p.A300V	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	392	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		CTCTAGCTGCGCGATCAGCTC	0.607000													6	25					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27206684	27206684	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:27206684C>T	ENST00000380036.4	+	15	2911	c.2469C>T	c.(2467-2469)gaC>gaT	p.D823D	TEK_ENST00000406359.4_Silent_p.D780D|TEK_ENST00000519097.1_Silent_p.D675D	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	823					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ACTGGAATGACATCAAATTTC	0.458000													9	9					0	0	1	0	0
PDIK1L	149420	broad.mit.edu	37	1	26448718	26448718	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26448718G>A	ENST00000374271.4	+	4	963	c.676G>A	c.(676-678)Gct>Act	p.A226T	PDIK1L_ENST00000374269.1_Missense_Mutation_p.A226T	NM_001243532.1|NM_001243533.1|NM_152835.4	NP_001230461.1|NP_001230462.1|NP_690048.1	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	226	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	7		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		TTTTTACATGGCTCCTGAAGT	0.438000													26	30					0	0	1	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135116328	135116328	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:135116328C>T	ENST00000368563.2	-	2	474	c.118G>A	c.(118-120)Gtc>Atc	p.V40I	TUBGCP2_ENST00000252936.3_Missense_Mutation_p.V40I|TUBGCP2_ENST00000470829.1_5'UTR|TUBGCP2_ENST00000543663.1_Missense_Mutation_p.V40I|TUBGCP2_ENST00000417178.2_Intron	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	40					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		GTGGTAGTGACGTACGGGGTC	0.572000													15	41					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88300528	88300528	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:88300528C>T	ENST00000418177.2	-	8	2690	c.2323G>A	c.(2323-2325)Gcc>Acc	p.A775T	GRM5_ENST00000455756.2_Missense_Mutation_p.A775T|GRM5_ENST00000305432.5_Missense_Mutation_p.A775T|GRM5_ENST00000305447.4_Missense_Mutation_p.A775T|GRM5_ENST00000393297.1_Missense_Mutation_p.A775T			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	775					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ATTGTGAAGGCGATATACTTG	0.438000													40	76					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6194781	6194781	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:6194781G>A	ENST00000262450.3	-	19	3108	c.3009C>T	c.(3007-3009)gcC>gcT	p.A1003A	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1003					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AACCTACCACGGCAGCCACAG	0.592000													28	42					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754985	76754985	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:76754985C>T	ENST00000537592.2	+	2	2994	c.2994C>T	c.(2992-2994)agC>agT	p.S998S	SALL3_ENST00000575389.2_Intron|SALL3_ENST00000536229.3_Intron	NM_171999.3	NP_741996.2	Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	998					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		ACTACCGCAGCCATACTAAGG	0.542000													18	19					0	0	1	0	0
ELFN1	392617	broad.mit.edu	37	7	1785521	1785521	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:1785521T>C	ENST00000424383.2	+	3	1776	c.1289T>C	c.(1288-1290)gTg>gCg	p.V430A	ELFN1_ENST00000541472.1_Missense_Mutation_p.V430A|ELFN1_ENST00000561626.1_Missense_Mutation_p.V430A					extracellular leucine-rich repeat and fibronectin type III domain containing 1											endometrium(1)	1						TTCGGCATGGTGCTGGTGCTG	0.697000													2	2					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127730740	127730740	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:127730740C>T	ENST00000368676.4	-	19	2487	c.2178G>A	c.(2176-2178)tcG>tcA	p.S726S	ADAM12_ENST00000368679.4_Intron	NM_021641.3	NP_067673.2	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	0					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CATGCTCCTGCGATCCCACGG	0.602000													9	18					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89350883	89350883	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:89350883G>A	ENST00000301030.4	-	9	2527	c.2067C>T	c.(2065-2067)caC>caT	p.H689H	ANKRD11_ENST00000378330.2_Silent_p.H689H	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	689	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GGTCGCGATCGTGCTTTAACA	0.338000													45	79					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685810	100685810	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100685810C>T	ENST00000306151.4	+	3	11177	c.11113C>T	c.(11113-11115)Cgt>Tgt	p.R3705C		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3705	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGCACCACACGTGTGACCAG	0.502000													24	93					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36767992	36767992	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:36767992G>A	ENST00000361475.2	-	9	1337	c.1164C>T	c.(1162-1164)taC>taT	p.Y388Y	TGM2_ENST00000536724.1_Silent_p.Y328Y|TGM2_ENST00000536701.1_Silent_p.Y307Y	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	388					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	AGGGCGCATCGTACTTGGTGC	0.587000													16	29					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37691600	37691600	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:37691600G>A	ENST00000315215.7	+	11	1925	c.1562G>A	c.(1561-1563)cGc>cAc	p.R521H	GPR124_ENST00000412232.2_Missense_Mutation_p.R521H			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	521					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GCCCTGGAGCGCATTGGGGGG	0.687000													14	17					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5536527	5536527	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5536527G>A	ENST00000380184.1	-	1	1408	c.1145C>T	c.(1144-1146)gCc>gTc	p.A382V	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	382										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GCTAGGTAAGGCTGGTATCCA	0.488000													38	49					0	0	1	0	0
SIK2	23235	broad.mit.edu	37	11	111592580	111592580	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:111592580C>T	ENST00000304987.3	+	13	2144	c.1971C>T	c.(1969-1971)agC>agT	p.S657S		NM_015191.1	NP_056006.1	Q9H0K1	SIK2_HUMAN	salt-inducible kinase 2	657					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	30						AGCAGGAAAGCGTCTCCACTC	0.562000													3	18					0	0	1	0	0
HOXA4	3201	broad.mit.edu	37	7	27169077	27169077	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:27169077G>A	ENST00000360046.5	-	2	795	c.730C>T	c.(730-732)Cgc>Tgc	p.R244C	HOXA4_ENST00000428284.2_Missense_Mutation_p.R244C|HOXA3_ENST00000467897.2_5'UTR|HOXA-AS2_ENST00000521159.1_RNA	NM_002141.4	NP_002132.3	Q00056	HXA4_HUMAN	homeobox A4	244						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(6)	12						TCGATGCGGCGCCGCCGGGTC	0.582000													29	47					0	0	1	0	0
ADAM17	6868	broad.mit.edu	37	2	9637268	9637268	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:9637268C>T	ENST00000310823.3	-	14	1940	c.1758G>A	c.(1756-1758)caG>caA	p.Q586Q		NM_003183.4	NP_003174.3	P78536	ADA17_HUMAN	ADAM metallopeptidase domain 17	586	Cys-rich.				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			breast(1)|cervix(4)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	28	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		ACTCCAGCTGCTGTTCCCTCT	0.517000													29	38					0	0	1	0	0
NAA50	80218	broad.mit.edu	37	3	113442298	113442298	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:113442298C>T	ENST00000240922.2	-	3	560	c.236G>A	c.(235-237)tGt>tAt	p.C79Y	NAA50_ENST00000497525.1_Missense_Mutation_p.C5Y|NAA50_ENST00000497255.1_Intron|NAA50_ENST00000477813.1_Intron|NAA50_ENST00000493900.1_Missense_Mutation_p.C78Y|NAA50_ENST00000493454.1_Missense_Mutation_p.C5Y	NM_025146.2	NP_079422.1	Q9GZZ1	NAA50_HUMAN	N(alpha)-acetyltransferase 50, NatE catalytic subunit	79	Coenzyme A binding.|N-acetyltransferase.				N-terminal protein amino acid acetylation	cytoplasm	N-acetyltransferase activity|protein binding			large_intestine(2)|lung(2)|skin(1)	5						AGGTGCCAGACATCCTAGTGT	0.388000													19	31					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54147579	54147579	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:54147579G>A	ENST00000265572.3	-	3	647	c.350C>T	c.(349-351)aCg>aTg	p.T117M	RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000520287.1_Missense_Mutation_p.T117M|OPRK1_ENST00000524278.1_Missense_Mutation_p.T28M	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	117					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CAAGTAGACCGTACTCTGAAA	0.403000													29	59					0	0	1	0	0
ZFX	7543	broad.mit.edu	37	X	24225495	24225495	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:24225495C>T	ENST00000379177.1	+	7	1126	c.699C>T	c.(697-699)gaC>gaT	p.D233D	ZFX_ENST00000379188.3_Silent_p.D233D|ZFX_ENST00000459724.1_3'UTR|ZFX_ENST00000539115.1_Silent_p.D4D|ZFX_ENST00000338565.3_Intron|ZFX_ENST00000540034.1_Silent_p.D272D|ZFX_ENST00000304543.5_Silent_p.D233D	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						TGACCATGGACACAGAGTCGG	0.388000													55	9					0	0	1	0	0
ZNF436	80818	broad.mit.edu	37	1	23688553	23688553	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:23688553G>A	ENST00000314011.4	-	4	1458	c.1322C>T	c.(1321-1323)aCg>aTg	p.T441M	ZNF436_ENST00000374608.3_Missense_Mutation_p.T441M|ZNF436_ENST00000374609.1_Intron	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	441					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		TTTCTCTCCCGTGTGAACTCT	0.463000													53	60					0	0	1	0	0
ERCC6L2	375748	broad.mit.edu	37	9	98775458	98775458	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:98775458C>T	ENST00000407474.3	+	4	2082	c.1569C>T	c.(1567-1569)aaC>aaT	p.N523N				Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	0	Helicase C-terminal.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										CAGATGAAAACGCAACCAATA	0.393000													24	34					0	0	1	0	0
ACTL6A	86	broad.mit.edu	37	3	179287663	179287663	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:179287663G>A	ENST00000429709.2	+	2	290	c.77G>A	c.(76-78)gGt>gAt	p.G26D	ACTL6A_ENST00000450518.2_5'UTR|ACTL6A_ENST00000392662.1_5'UTR	NM_004301.3	NP_004292.1	O96019	ACL6A_HUMAN	actin-like 6A	26					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|urinary_tract(1)	21	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			GTGAGAGCTGGTTATGCTGGT	0.348000													10	76					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236746392	236746392	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:236746392G>A	ENST00000366582.3	-	18	2460	c.2346C>T	c.(2344-2346)gcC>gcT	p.A782A	HEATR1_ENST00000366581.2_Silent_p.A782A	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	782					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			AGTCCTCCACGGCCACCCTCT	0.433000													56	87					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	29102917	29102917	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:29102917G>A	ENST00000524189.1	-	2	133	c.95C>T	c.(94-96)gCa>gTa	p.A32V	KIF13B_ENST00000521515.1_Missense_Mutation_p.A32V	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	32	Kinesin-motor.				microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		AACCTTGTTTGCATCCACATC	0.358000													6	8					0	0	1	0	0
VAMP7	6845	broad.mit.edu	37	X	155169449	155169449	+	Missense_Mutation	SNP	G	G	A	rs141889109	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:155169449G>A	ENST00000286448.6	+	7	751	c.586G>A	c.(586-588)Gta>Ata	p.V196I	VAMP7_ENST00000460621.1_Missense_Mutation_p.V155I|VAMP7_ENST00000262640.6_Missense_Mutation_p.R173H|VAMP7_ENST00000479687.1_3'UTR	NM_001145149.2|NM_005638.5	NP_001138621.1|NP_005629.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	196					calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CATCATCATCGTATCAATTGT	0.348000													10	86					0	0	1	0	0
FNIP2	57600	broad.mit.edu	37	4	159790204	159790204	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:159790204G>A	ENST00000264433.6	+	13	2491	c.2416G>A	c.(2416-2418)Gca>Aca	p.A806T	FNIP2_ENST00000379346.3_Missense_Mutation_p.A829T	NM_020840.1	NP_065891.1	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	806	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		AAACGACATGGCAGCAGATAT	0.587000													42	52					0	0	1	0	0
NPLOC4	55666	broad.mit.edu	37	17	79536061	79536061	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79536061T>C	ENST00000374747.5	-	14	1559	c.1430A>G	c.(1429-1431)gAt>gGt	p.D477G	NPLOC4_ENST00000539314.1_Missense_Mutation_p.D316G|NPLOC4_ENST00000331134.6_Missense_Mutation_p.D477G			Q8TAT6	NPL4_HUMAN	nuclear protein localization 4 homolog (S. cerevisiae)	477					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	11	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			ACCCAATACATCCCGGTTTTC	0.358000													15	26					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72067036	72067036	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:72067036A>G	ENST00000265381.4	-	9	2191		c.e9+1			NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1						axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GTAAGTACCCACATCTTTACA	0.532000													12	68					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183703152	183703152	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:183703152G>A	ENST00000382494.2	-	6	720	c.606C>T	c.(604-606)ggC>ggT	p.G202G	ABCC5_ENST00000334444.6_Intron|ABCC5_ENST00000265586.6_Intron|ABCC5_ENST00000392579.2_Intron|ABCC5_ENST00000427120.2_3'UTR	NM_001023587.1	NP_001018881.1	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	0	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCAGAATACAGCCATCCTGAA	0.488000													35	64					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56388088	56388088	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:56388088G>A	ENST00000423270.1	-	9	1837	c.1838C>T	c.(1837-1839)aCg>aTg	p.T613M	RFX7_ENST00000317318.6_Missense_Mutation_p.T613M|RFX7_ENST00000559447.2_Missense_Mutation_p.T516M|RFX7_ENST00000422057.1_Missense_Mutation_p.T516M	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	516					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						GCCTGTTGACGTGCCTGGCAG	0.418000													10	19					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168074807	168074807	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:168074807G>A	ENST00000409195.1	+	5	944	c.855G>A	c.(853-855)gaG>gaA	p.E285E	XIRP2_ENST00000420519.1_Silent_p.E318E|XIRP2_ENST00000409728.1_Silent_p.E318E|XIRP2_ENST00000409756.2_Silent_p.E285E|XIRP2_ENST00000295237.9_Silent_p.E285E|XIRP2_ENST00000409605.1_Silent_p.E63E|XIRP2_ENST00000409273.1_Silent_p.E63E|XIRP2_ENST00000409043.1_Silent_p.E285E	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	110					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACAGATCTGAGCAGGTAATAC	0.388000													5	40					0	0	1	0	0
UNC80	285175	broad.mit.edu	37	2	210642204	210642204	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:210642204G>A	ENST00000439458.1	+	4	601	c.521G>A	c.(520-522)cGa>cAa	p.R174Q	UNC80_ENST00000478701.1_3'UTR|UNC80_ENST00000272845.5_Missense_Mutation_p.R174Q	NM_032504.1	NP_115893.1	Q8N2C7	UNC80_HUMAN	unc-80 homolog (C. elegans)	174						integral to membrane		p.R174Q(2)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)	20						GAGAACAACCGAAGAAAGATC	0.502000													32	58					0	0	1	0	0
ORAI3	93129	broad.mit.edu	37	16	30964860	30964860	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30964860G>A	ENST00000318663.4	+	2	807	c.583G>A	c.(583-585)Ggg>Agg	p.G195R	ORAI3_ENST00000562699.1_Intron|ORAI3_ENST00000566237.1_Missense_Mutation_p.G195R|AC135048.13_ENST00000566056.1_RNA	NM_152288.2	NP_689501.1	Q9BRQ5	ORAI3_HUMAN	ORAI calcium release-activated calcium modulator 3	195						integral to membrane	protein binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6						CCGGGTGCCCGGGACTCTGGC	0.627000											OREG0023742	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	99	143					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46564389	46564389	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46564389C>T	ENST00000458649.2	-	7	1596	c.1178G>A	c.(1177-1179)cGc>cAc	p.R393H	AMBRA1_ENST00000533727.1_Missense_Mutation_p.R303H|AMBRA1_ENST00000314845.3_Missense_Mutation_p.R303H|AMBRA1_ENST00000528950.1_Missense_Mutation_p.R393H|AMBRA1_ENST00000426438.1_Missense_Mutation_p.R393H|AMBRA1_ENST00000298834.3_Missense_Mutation_p.R393H|AMBRA1_ENST00000534300.1_Missense_Mutation_p.R393H			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	393					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		TCCCAAAGAGCGGCGGGTAGG	0.607000													16	35					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138630553	138630553	+	Silent	SNP	C	C	T	rs150041781	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:138630553C>T	ENST00000218099.2	+	5	430	c.423C>T	c.(421-423)tgC>tgT	p.C141C	F9_ENST00000394090.2_Silent_p.C103C	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	141	EGF-like 2.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	ATGGCAGATGCGAGCAGTTTT	0.383000													22	24					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51192762	51192762	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:51192762G>A	ENST00000245441.5	-	30	6291	c.6101C>T	c.(6100-6102)aCt>aTt	p.T2034I	NIN_ENST00000530997.2_Missense_Mutation_p.T2034I|NIN_ENST00000389868.3_3'UTR|NIN_ENST00000382041.3_Missense_Mutation_p.T2034I|NIN_ENST00000382043.4_Missense_Mutation_p.T1321I|NIN_ENST00000324330.9_3'UTR	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	2034					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					CTCCATGACAGTTACCAGTTG	0.388000			T	PDGFRB	MPD								30	31					0	0	1	0	0
ENTPD3	956	broad.mit.edu	37	3	40457492	40457492	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:40457492G>A	ENST00000301825.3	+	7	877	c.759G>A	c.(757-759)acG>acA	p.T253T	ENTPD3_ENST00000445129.1_Silent_p.T253T|ENTPD3_ENST00000456402.1_Silent_p.T253T|ENTPD3-AS1_ENST00000439293.1_RNA|ENTPD3-AS1_ENST00000452768.1_RNA|ENTPD3-AS1_ENST00000425156.1_RNA	NM_001248.2	NP_001239.2	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase 3	253						integral to membrane	ATP binding|hydrolase activity	p.T253T(1)		endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		ACGTATACACGCTCTACACAC	0.542000													12	9					0	0	1	0	0
CERCAM	51148	broad.mit.edu	37	9	131191242	131191242	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131191242C>T	ENST00000372842.1	+	9	3907	c.763C>T	c.(763-765)Cgt>Tgt	p.R255C	CERCAM_ENST00000372838.4_Missense_Mutation_p.R333C			Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule	333					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				endometrium(2)|kidney(4)|large_intestine(2)|lung(9)|ovary(1)|pancreas(2)	20						CAGGCCTGACCGTCGGGAACG	0.667000													4	5					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34646000	34646000	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:34646000G>T	ENST00000537011.1	+	5	1384	c.1002G>T	c.(1000-1002)caG>caT	p.Q334H	NUTM1_ENST00000333756.4_Missense_Mutation_p.Q306H|NUTM1_ENST00000438749.3_Missense_Mutation_p.Q324H					NUT midline carcinoma, family member 1																		ATGGGTCTCAGGGCCTGTCTC	0.537000													35	46					1.36161e-19	1.50697e-19	1	1	0
BCL9	607	broad.mit.edu	37	1	147096381	147096381	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:147096381A>G	ENST00000234739.3	+	10	4642	c.3902A>G	c.(3901-3903)gAc>gGc	p.D1301G		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1301	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					GGAACTCCGGACATCCCTCTT	0.577000			T	"""IGH@, IGL@"""	B-ALL								15	14					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587175	247587175	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247587175G>A	ENST00000366497.2	+	4	1210	c.430G>A	c.(430-432)Gtg>Atg	p.V144M	NLRP3_ENST00000391828.3_Missense_Mutation_p.V144M|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000336119.3_Missense_Mutation_p.V144M|NLRP3_ENST00000348069.2_Missense_Mutation_p.V144M|NLRP3_ENST00000366496.2_Missense_Mutation_p.V144M|NLRP3_ENST00000391827.2_Missense_Mutation_p.V144M	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	144					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAGAAAGTACGTGAGAAGCAG	0.507000													4	20					0	0	1	0	0
EXOC6	54536	broad.mit.edu	37	10	94679782	94679782	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:94679782G>A	ENST00000371552.4	+	8	877	c.848G>A	c.(847-849)cGa>cAa	p.R283Q	EXOC6_ENST00000260762.6_Missense_Mutation_p.R288Q|EXOC6_ENST00000371547.4_Missense_Mutation_p.R304Q|EXOC6_ENST00000443748.2_Intron	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	288					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				CCTGTTTATCGATGTTTGCAC	0.264000													6	14					0	0	1	0	0
ARSK	153642	broad.mit.edu	37	5	94903715	94903715	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:94903715T>C	ENST00000380009.4	+	3	583	c.378T>C	c.(376-378)ttT>ttC	p.F126F		NM_198150.2	NP_937793.1	Q6UWY0	ARSK_HUMAN	arylsulfatase family, member K	126						extracellular region	arylsulfatase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(1)	16		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		CACAGAAATTTGGGAAACTGG	0.388000													10	25					0	0	1	0	0
SNX4	8723	broad.mit.edu	37	3	125216976	125216976	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:125216976T>C	ENST00000251775.4	-	3	350	c.326A>G	c.(325-327)gAa>gGa	p.E109G	SNX4_ENST00000536067.1_5'UTR|SNX4_ENST00000473417.1_5'UTR	NM_003794.2	NP_003785.1	O95219	SNX4_HUMAN	sorting nexin 4	109	PX.				cell communication|endocytic recycling|endocytosis|protein transport	cytoplasmic dynein complex|early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|central_nervous_system(1)|lung(6)|ovary(1)|skin(1)	11						CAACTCAAATTCACTATATCG	0.393000													22	67					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127797040	127797040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:127797040G>A	ENST00000556132.1	-	6	2995	c.2131C>T	c.(2131-2133)Cag>Tag	p.Q711*	SOGA3_ENST00000481848.2_Nonsense_Mutation_p.Q711*|SOGA3_ENST00000368268.2_Nonsense_Mutation_p.Q711*|SOGA3_ENST00000525778.1_Nonsense_Mutation_p.Q711*|SOGA3_ENST00000465909.2_Nonsense_Mutation_p.Q711*	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	711						integral to membrane											TCGTTGATCTGCAGGCGCGCC	0.632000													34	41					0	0	1	0	0
PNMAL2	57469	broad.mit.edu	37	19	46998410	46998410	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46998410G>A	ENST00000599531.1	-	1	1345	c.313C>T	c.(313-315)Cag>Tag	p.Q105*	PNMAL2_ENST00000594749.1_Intron|AC011484.1_ENST00000377652.3_Missense_Mutation_p.C174Y|PNMAL2_ENST00000377655.2_Nonsense_Mutation_p.Q105*	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	105										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CGTCTCATCTGCCTCAGGACC	0.687000													10	114					0	0	1	0	0
ELAVL3	1995	broad.mit.edu	37	19	11565665	11565665	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11565665C>T	ENST00000359227.3	-	7	1204	c.780G>A	c.(778-780)tcG>tcA	p.S260S	ELAVL3_ENST00000438662.2_Silent_p.S253S	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	260					cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						TGGCGATCGGCGAGAACCTGG	0.682000													54	98					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5039901	5039901	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5039901G>A	ENST00000159111.4	+	4	414	c.196G>A	c.(196-198)Gtg>Atg	p.V66M	KDM4B_ENST00000536461.1_Missense_Mutation_p.V66M|KDM4B_ENST00000381759.4_Missense_Mutation_p.V66M	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	66					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CATCGACGACGTGGTGATCCC	0.612000													20	36					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	95993352	95993352	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95993352C>T	ENST00000297954.4	+	3	1037	c.1037C>T	c.(1036-1038)gCc>gTc	p.A346V	WNK2_ENST00000349097.3_5'UTR|WNK2_ENST00000395477.2_Missense_Mutation_p.A346V|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000395475.2_Missense_Mutation_p.A332V|WNK2_ENST00000427277.2_5'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	346	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						TTGGGCCTGGCCACTCTGAAA	0.537000													45	66					0	0	1	0	0
SLC25A37	51312	broad.mit.edu	37	8	23423701	23423701	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:23423701C>T	ENST00000519973.1	+	2	489	c.291C>T	c.(289-291)acC>acT	p.T97T	SLC25A37_ENST00000517923.1_3'UTR	NM_016612.2	NP_057696.2	Q9NYZ2	MFRN1_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 37	97					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				NS(1)|endometrium(3)|large_intestine(2)|lung(8)|urinary_tract(1)	15		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)		TCATGCGGACCGAAGGCTTCT	0.532000													16	21					0	0	1	0	0
ZNF226	7769	broad.mit.edu	37	19	44680182	44680182	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44680182A>G	ENST00000590089.1	+	7	1134	c.767A>G	c.(766-768)gAg>gGg	p.E256G	ZNF226_ENST00000337433.5_Missense_Mutation_p.E256G|ZNF226_ENST00000588883.1_3'UTR|ZNF226_ENST00000454662.2_Missense_Mutation_p.E256G			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				CAGTGTAATGAGTGTAAAAAA	0.383000													14	29					0	0	1	0	0
ELOVL6	79071	broad.mit.edu	37	4	110972738	110972738	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:110972738G>A	ENST00000394607.3	-	5	717	c.554C>T	c.(553-555)gCg>gTg	p.A185V	ELOVL6_ENST00000302274.3_Missense_Mutation_p.A185V			Q9H5J4	ELOV6_HUMAN	ELOVL fatty acid elongase 6	185					fatty acid elongation, saturated fatty acid|long-chain fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process		fatty acid elongase activity|protein binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	8				OV - Ovarian serous cystadenocarcinoma(123;0.00462)		GAAACCTGCCGCCCGCAAGGC	0.527000													19	20					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126781226	126781226	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:126781226G>A	ENST00000274473.6	+	21	2836	c.2569G>A	c.(2569-2571)Ggg>Agg	p.G857R	MEGF10_ENST00000510828.1_Intron|MEGF10_ENST00000503335.2_Missense_Mutation_p.G857R	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	857	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CTACCAGATCGGGGCCATTGC	0.433000													35	55					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230456385	230456385	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:230456385G>T	ENST00000341772.4	-	2	630	c.496C>A	c.(496-498)Ctg>Atg	p.L166M		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	166					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		GAGCGAGGCAGGATTTTGTCA	0.552000													10	18					1.58986e-06	1.65464e-06	1	1	0
CCR1	1230	broad.mit.edu	37	3	46244868	46244868	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:46244868G>A	ENST00000296140.3	-	2	1062	c.937C>T	c.(937-939)Cgg>Tgg	p.R313W	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	313					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		AACAACTGCCGCAGGTACTTC	0.597000													16	11					0	0	1	0	0
CEMP1	752014	broad.mit.edu	37	16	2581028	2581028	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2581028C>T	ENST00000382350.1	-	1	392	c.47G>A	c.(46-48)tGc>tAc	p.C16Y	CEMP1_ENST00000567119.1_Missense_Mutation_p.C16Y|AMDHD2_ENST00000302956.4_3'UTR|CEMP1_ENST00000565480.1_Missense_Mutation_p.C16Y|AMDHD2_ENST00000565570.1_3'UTR			Q6PRD7	CEMP1_HUMAN	cementum protein 1	16						cytoplasm				lung(1)|skin(1)	2						AGAGGTTGAGCATCGCCTGTG	0.617000													20	45					0	0	1	0	0
DLL1	28514	broad.mit.edu	37	6	170594658	170594658	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:170594658C>A	ENST00000366756.3	-	6	1194	c.862_splice	c.e6+1	p.Q287_splice		NM_005618.3	NP_005609.3	O00548	DLL1_HUMAN	delta-like 1 (Drosophila)	287					cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			NS(2)|breast(1)|endometrium(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	33		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		AAGGCTTACCCTGGTTGCAGA	0.577000													16	27					1.33834e-09	1.42249e-09	1	1	0
FZD4	8322	broad.mit.edu	37	11	86662967	86662967	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:86662967C>T	ENST00000531380.1	-	2	1136	c.831G>A	c.(829-831)cgG>cgA	p.R277R	PRSS23_ENST00000533902.2_3'UTR	NM_012193.3	NP_036325.2	Q9ULV1	FZD4_HUMAN	frizzled family receptor 4	277					canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			breast(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(6)|skin(1)	21		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ATATCCTTTCCCGGCCTACAG	0.408000													15	14					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29126255	29126255	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:29126255C>A	ENST00000261590.8	+	15	3115	c.2906C>A	c.(2905-2907)gCt>gAt	p.A969D	RP11-75N4.2_ENST00000583706.1_RNA	NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	969					cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGGGTGTATGCTCCAGCTTCT	0.498000													23	30					3.10358e-05	3.20141e-05	1	1	0
MYLK	4638	broad.mit.edu	37	3	123426765	123426765	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:123426765G>A	ENST00000360772.3	-	17	2604	c.2226C>T	c.(2224-2226)tgC>tgT	p.C742C	MYLK_ENST00000346322.5_Silent_p.C673C|MYLK_ENST00000360304.3_Silent_p.C742C|MYLK_ENST00000359169.1_Silent_p.C742C|MYLK_ENST00000475616.1_Silent_p.C742C			Q15746	MYLK_HUMAN	myosin light chain kinase	742	Ig-like C2-type 6.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CAGCTATGGCGCAGGAGATGA	0.577000													12	15					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176860983	176860983	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176860983C>T	ENST00000355472.5	+	9	975	c.807C>T	c.(805-807)ggC>ggT	p.G269G	GRK6_ENST00000355958.5_Silent_p.G269G|GRK6_ENST00000528793.1_Silent_p.G269G|GRK6_ENST00000393576.3_Intron|GRK6_ENST00000507633.1_Silent_p.G269G	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	269	Protein kinase.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGAACGGGGGCGACCTCAAGT	0.657000													9	15					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24547556	24547556	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:24547556C>T	ENST00000535378.1	-	22	3671	c.3029G>A	c.(3028-3030)aGc>aAc	p.S1010N	KIAA0319_ENST00000378214.3_Missense_Mutation_p.S1019N|KIAA0319_ENST00000430948.2_Missense_Mutation_p.S974N|KIAA0319_ENST00000543707.1_Missense_Mutation_p.S1019N|KIAA0319_ENST00000537886.1_Missense_Mutation_p.S958N	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	1019					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GTGCTCTGTGCTTCGGTGCTT	0.512000													13	30					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58064443	58064443	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58064443G>A	ENST00000357272.4	+	3	706		c.e3-1		FLNB_ENST00000490882.1_Splice_Site|FLNB_ENST00000295956.4_Splice_Site|FLNB_ENST00000493452.1_Splice_Site|FLNB_ENST00000358537.3_Splice_Site|FLNB_ENST00000429972.2_Splice_Site|FLNB_ENST00000419752.2_Splice_Site|FLNB_ENST00000348383.5_Splice_Site			O75369	FLNB_HUMAN	filamin B, beta						actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TCTGTTAACAGGTCTGTGCCC	0.473000													11	16					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4856948	4856948	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:4856948C>T	ENST00000536091.1	-	6	1621	c.1489G>A	c.(1489-1491)Ggc>Agc	p.G497S	RADIL_ENST00000538469.1_Silent_p.T310T|RADIL_ENST00000399583.3_Silent_p.T550T			Q96JH8	RADIL_HUMAN	Ras association and DIL domains	882	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CCTCGCTGGCCGTCAGCGTGC	0.637000													10	21					0	0	1	0	0
ASPN	54829	broad.mit.edu	37	9	95228839	95228839	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95228839G>A	ENST00000375544.3	-	4	645	c.402C>T	c.(400-402)aaC>aaT	p.N134N	ASPN_ENST00000395538.3_Silent_p.N134N|ASPN_ENST00000375543.1_Silent_p.N134N|CENPP_ENST00000375587.3_Intron	NM_017680.4	NP_060150.4	Q9BXN1	ASPN_HUMAN	asporin	134					bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	9						GCTTGTTGTTGTTCAGGATCA	0.383000													27	77					0	0	1	0	0
EFNA2	1943	broad.mit.edu	37	19	1295701	1295701	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1295701G>A	ENST00000215368.2	+	2	313	c.298G>A	c.(298-300)Gcc>Acc	p.A100T	MUM1_ENST00000344663.3_Intron	NM_001405.3	NP_001396.2	O43921	EFNA2_HUMAN	ephrin-A2	100					cell-cell signaling	anchored to membrane|plasma membrane	ephrin receptor binding			lung(2)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGAGGGCCACGCCTCCTGCGA	0.687000													8	14					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	66030196	66030196	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:66030196C>T	ENST00000443035.3	-	7	1104	c.889G>A	c.(889-891)Gca>Aca	p.A297T	DENND4A_ENST00000431932.2_Missense_Mutation_p.A297T	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						TTCCCATCTGCTGATGTTAAA	0.383000													5	5					0	0	1	0	0
SLC22A15	55356	broad.mit.edu	37	1	116569517	116569517	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:116569517C>T	ENST00000369503.4	+	5	732	c.602C>T	c.(601-603)tCg>tTg	p.S201L	SLC22A15_ENST00000369502.1_Missense_Mutation_p.S201L	NM_018420.2	NP_060890.2	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	201					ion transport	integral to membrane	transmembrane transporter activity	p.S201L(2)		endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|urinary_tract(1)	17	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GAATTAGGATCGATTGGCGGC	0.498000													51	76					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139611048	139611048	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:139611048G>T	ENST00000303045.6	-	61	4725	c.4279C>A	c.(4279-4281)Ctg>Atg	p.L1427M	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Missense_Mutation_p.L1407M	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1427	Collagen-like 14.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGACCCATCAGGCCTGTGTGG	0.597000										HNSCC(7;0.00092)			16	24					1.3612e-06	1.41782e-06	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152674874	152674874	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152674874C>T	ENST00000367255.5	-	68	11533	c.10932G>A	c.(10930-10932)tgG>tgA	p.W3644*	SYNE1_ENST00000448038.1_Nonsense_Mutation_p.W3629*|SYNE1_ENST00000341594.5_Nonsense_Mutation_p.W3615*|SYNE1_ENST00000423061.1_Nonsense_Mutation_p.W3629*|SYNE1_ENST00000265368.4_Nonsense_Mutation_p.W3644*	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3644					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTCTTCGTGCCACTTCTGAA	0.438000										HNSCC(10;0.0054)			26	49					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74673183	74673183	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:74673183T>C	ENST00000334011.5	+	6	1126	c.908T>C	c.(907-909)gTc>gCc	p.V303A		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	303	ZP.					nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					GGCACCCATGTCAACATCCTC	0.547000													26	38					0	0	1	0	0
RNF32	140545	broad.mit.edu	37	7	156437440	156437440	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:156437440C>T	ENST00000392741.2	+	2	351	c.263C>T	c.(262-264)cCg>cTg	p.P88L	RNF32_ENST00000343665.4_Missense_Mutation_p.P88L|RNF32_ENST00000311822.8_Missense_Mutation_p.P88L|RNF32_ENST00000432459.2_Missense_Mutation_p.P88L|RNF32_ENST00000317955.5_Missense_Mutation_p.P88L|RNF32_ENST00000405335.1_Missense_Mutation_p.P88L|RNF32_ENST00000392740.1_Missense_Mutation_p.P88L|RNF32_ENST00000480011.1_3'UTR|RNF32_ENST00000392743.2_Missense_Mutation_p.P88L			Q9H0A6	RNF32_HUMAN	ring finger protein 32	88						aggresome|endosome	protein binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(2)	15	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		AAACCGCCGCCGTTGACTTTG	0.343000													27	53					0	0	1	0	0
ALDH1A1	216	broad.mit.edu	37	9	75531836	75531836	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:75531836C>A	ENST00000297785.3	-	9	1089	c.1035_splice	c.e9+1	p.Q345_splice		NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	345					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTATACTTACCTGAGGGCCTT	0.398000													4	58					0.000602214	0.000612743	1	1	0
KIAA1109	84162	broad.mit.edu	37	4	123227142	123227142	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:123227142T>C	ENST00000264501.4	+	57	10156	c.9783T>C	c.(9781-9783)gcT>gcC	p.A3261A	KIAA1109_ENST00000455637.1_Silent_p.A3261A|KIAA1109_ENST00000388738.3_Silent_p.A3261A			Q2LD37	K1109_HUMAN	KIAA1109	3261					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						ATAGGGAAGCTGTGCTTATTA	0.388000													25	106					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36103833	36103833	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:36103833G>T	ENST00000258840.6	-	33	4955	c.4565C>A	c.(4564-4566)cCt>cAt	p.P1522H	RALGAPA1_ENST00000382366.3_Missense_Mutation_p.P1488H|RALGAPA1_ENST00000307138.6_Missense_Mutation_p.P1475H|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.P1475H			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	1475	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AGAGTGCAGAGGCTCAGGCTC	0.418000													21	26					6.44725e-10	6.8705e-10	1	1	0
EPHA1	2041	broad.mit.edu	37	7	143091383	143091383	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:143091383G>T	ENST00000275815.3	-	15	2492	c.2406C>A	c.(2404-2406)atC>atA	p.I802I		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	802	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CTGTGGTGAAGATCCGATGGG	0.547000													16	27					1.02788e-11	1.10723e-11	1	1	0
EBF2	64641	broad.mit.edu	37	8	25716010	25716010	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:25716010G>A	ENST00000520164.1	-	14	1890	c.1353C>T	c.(1351-1353)cgC>cgT	p.R451R	EBF2_ENST00000408929.3_Silent_p.R303R|EBF2_ENST00000535548.1_Silent_p.R182R	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	451					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TGCTTGTGTTGCGGATGTACC	0.522000													22	24					0	0	1	0	0
ARNTL2	56938	broad.mit.edu	37	12	27533279	27533279	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:27533279T>C	ENST00000544915.1	+	4	543	c.324T>C	c.(322-324)cgT>cgC	p.R108R	ARNTL2_ENST00000266503.5_Silent_p.R142R|ARNTL2_ENST00000395901.2_Silent_p.R105R|ARNTL2_ENST00000261178.5_Silent_p.R94R|ARNTL2_ENST00000542388.1_Silent_p.R57R|ARNTL2_ENST00000546179.1_Silent_p.R105R|ARNTL2_ENST00000311001.5_Silent_p.R128R	NM_020183.4	NP_064568.3	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear translocator-like 2	142					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	21	Colorectal(261;0.0847)|Lung SC(9;0.184)					CCATGGCGCGTAAACTGGACA	0.418000													42	47					0	0	1	0	0
PRKACA	5566	broad.mit.edu	37	19	14208433	14208433	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:14208433G>A	ENST00000308677.4	-	7	796	c.600C>T	c.(598-600)tgC>tgT	p.C200C	PRKACA_ENST00000590853.1_Intron|PRKACA_ENST00000589994.1_Silent_p.C192C|PRKACA_ENST00000350356.3_5'UTR	NM_002730.3	NP_002721.1	P17612	KAPCA_HUMAN	protein kinase, cAMP-dependent, catalytic, alpha	200	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding	p.C200C(1)		central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	16						CAGGGGTGCCGCACAAGGTCC	0.637000													8	18					0	0	1	0	0
SP2	6668	broad.mit.edu	37	17	45994483	45994483	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:45994483C>T	ENST00000376741.4	+	3	1183	c.1046C>T	c.(1045-1047)cCg>cTg	p.P349L	AC003665.1_ENST00000433001.1_RNA|AC003665.1_ENST00000451140.2_RNA|AC003665.1_ENST00000585280.1_RNA|AC003665.1_ENST00000411573.2_RNA	NM_003110.5	NP_003101.3	Q02086	SP2_HUMAN	Sp2 transcription factor	349					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	13						GCAGCTGAGCCGACACCTACT	0.577000													21	44					0	0	1	0	0
EDNRA	1909	broad.mit.edu	37	4	148453683	148453683	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:148453683C>T	ENST00000324300.5	+	4	1089	c.574C>T	c.(574-576)Cgt>Tgt	p.R192C	EDNRA_ENST00000506066.1_Intron|EDNRA_ENST00000511804.1_5'UTR|EDNRA_ENST00000339690.5_Missense_Mutation_p.S149L|EDNRA_ENST00000503721.1_3'UTR|EDNRA_ENST00000358556.4_Intron	NM_001957.3	NP_001948.1	P25101	EDNRA_HUMAN	endothelin receptor type A	192					activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)	17	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	CTCCTGGAGTCGTGTTCAGGG	0.408000													56	72					0	0	1	0	0
TIFAB	497189	broad.mit.edu	37	5	134785304	134785304	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:134785304C>T	ENST00000537858.1	-	2	526	c.326G>A	c.(325-327)gGc>gAc	p.G109D		NM_001099221.1	NP_001092691.1	Q6ZNK6	TIFAB_HUMAN	TRAF-interacting protein with forkhead-associated domain, family member B	109										breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CATCTGGATGCCTGAGAAGGA	0.577000													5	85					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93672762	93672762	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:93672762G>A	ENST00000343253.7	+	9	1518	c.1016G>A	c.(1015-1017)aGt>aAt	p.S339N	CCDC18_ENST00000401026.3_Missense_Mutation_p.S339N|CCDC18_ENST00000338949.4_Missense_Mutation_p.S138N|CCDC18_ENST00000334652.5_5'UTR|CCDC18_ENST00000557479.1_Missense_Mutation_p.S457N			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18	339										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TCTAGACAAAGTATTTTGAAG	0.333000													15	19					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19746265	19746265	+	Missense_Mutation	SNP	C	C	T	rs146115077		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19746265C>T	ENST00000203556.4	-	15	1656	c.1519G>A	c.(1519-1521)Gag>Aag	p.E507K	GMIP_ENST00000587238.1_Missense_Mutation_p.E481K|GMIP_ENST00000586269.1_5'UTR|GMIP_ENST00000445806.2_Missense_Mutation_p.E478K	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	507					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GCTTCGCACTCGCGGCACTTG	0.632000													14	30					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613263	179613263	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179613263A>G	ENST00000360870.5	-	46	14086	c.13864T>C	c.(13864-13866)Tat>Cat	p.Y4622H	TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	741	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATGAGAATACATTTGTTTT	0.363000													43	76					0	0	1	0	0
PDE3B	5140	broad.mit.edu	37	11	14840740	14840740	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:14840740T>G	ENST00000282096.4	+	7	2145	c.1792T>G	c.(1792-1794)Tgc>Ggc	p.C598G	PDE3B_ENST00000455098.2_Missense_Mutation_p.C547G	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	598					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TACAGATTGCTGCAGTGGAAA	0.299000													4	84					0	0	1	0	0
ULK2	9706	broad.mit.edu	37	17	19699557	19699557	+	Silent	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:19699557A>T	ENST00000395544.4	-	19	2347	c.1848T>A	c.(1846-1848)tcT>tcA	p.S616S	ULK2_ENST00000361658.2_Silent_p.S616S	NM_014683.3	NP_055498.3	Q8IYT8	ULK2_HUMAN	unc-51 like autophagy activating kinase 2	616					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					ACAGGTTGGAAGATGCTTGAG	0.413000													31	51					0	0	1	0	0
BIRC3	330	broad.mit.edu	37	11	102195288	102195288	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:102195288C>T	ENST00000263464.3	+	2	2798	c.48C>T	c.(46-48)agC>agT	p.S16S	BIRC3_ENST00000532808.1_Silent_p.S16S	NM_001165.4	NP_001156.1	Q13489	BIRC3_HUMAN	baculoviral IAP repeat containing 3	16					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|ovary(3)|skin(1)	21	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TGATGAAAAGCGCCAACACGT	0.403000			T	MALT1	MALT								21	48					0	0	1	0	0
SEBOX	645832	broad.mit.edu	37	17	26691899	26691899	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26691899G>A	ENST00000536498.1	-	9	1582	c.185C>T	c.(184-186)gCg>gTg	p.A62V	SEBOX_ENST00000438614.1_Missense_Mutation_p.A62V|TMEM199_ENST00000509083.1_Intron|SARM1_ENST00000379061.4_Intron|CTB-96E2.3_ENST00000591482.1_RNA|SEBOX_ENST00000431468.1_Missense_Mutation_p.A63V			Q9HB31	SEBOX_HUMAN	SEBOX homeobox	63					cell differentiation|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(1)|lung(1)|skin(1)	5	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		TGCTGCAAACGCCCTCTCCAG	0.627000													11	15					0	0	1	0	0
GMPR	2766	broad.mit.edu	37	6	16254845	16254845	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:16254845G>A	ENST00000259727.4	+	4	458	c.344G>A	c.(343-345)aGc>aAc	p.S115N		NM_006877.3	NP_006868.3	P36959	GMPR1_HUMAN	guanosine monophosphate reductase	115					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage|response to cold	cytosol	GMP reductase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	20	Breast(50;0.0427)|Ovarian(93;0.103)	all_hematologic(90;0.0895)				AAGATGACCAGCATCCTGGAA	0.448000													15	83					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2153765	2153765	+	Missense_Mutation	SNP	G	G	A	rs144979397	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2153765G>A	ENST00000262304.4	-	23	8501	c.8293C>T	c.(8293-8295)Cgc>Tgc	p.R2765C	PKD1_ENST00000423118.1_Missense_Mutation_p.R2765C|PKD1_ENST00000561991.1_5'UTR	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	2765	REJ.		R -> C.|R -> RILMR (in ADPKD1).		calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						ACGCGGGAGCGCATGAGGATG	0.692000													15	21					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50211246	50211246	+	Missense_Mutation	SNP	G	G	A	rs147135053		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50211246G>A	ENST00000002829.3	+	3	617	c.133G>A	c.(133-135)Gcc>Acc	p.A45T	SEMA3F_ENST00000434342.1_Missense_Mutation_p.A45T|SEMA3F_ENST00000413852.1_5'UTR	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	45	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		CACAGGCACCGCCCACTTCTT	0.567000													5	11					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197030913	197030913	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:197030913C>T	ENST00000367412.1	-	3	495		c.e3+1			NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide						blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						GATTCTTATACCATGTTCTTT	0.338000													20	27					0	0	1	0	0
SKIDA1	387640	broad.mit.edu	37	10	21804814	21804814	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:21804814C>T	ENST00000449193.2	-	4	4190	c.1938G>A	c.(1936-1938)acG>acA	p.T646T	SKIDA1_ENST00000444772.3_Silent_p.T567T	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1																		AGGGCAAATCCGTAGCAAATT	0.443000													27	36					0	0	1	0	0
SERINC3	10955	broad.mit.edu	37	20	43135507	43135507	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:43135507G>A	ENST00000342374.4	-	6	901	c.744C>T	c.(742-744)tgC>tgT	p.C248C	SERINC3_ENST00000255175.1_Silent_p.C248C|SERINC3_ENST00000541235.1_Silent_p.C193C	NM_006811.2	NP_006802.1	Q13530	SERC3_HUMAN	serine incorporator 3	248						integral to membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(2)|lung(8)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			AAGCCACAACGCAAAGGATCA	0.373000													23	34					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7230078	7230078	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:7230078G>A	ENST00000379938.2	+	10	2283	c.1746G>A	c.(1744-1746)ccG>ccA	p.P582P	RREB1_ENST00000379933.3_Silent_p.P582P|RREB1_ENST00000349384.6_Silent_p.P582P|RREB1_ENST00000334984.6_Silent_p.P582P	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	582					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TGCAGCAGCCGCGGGCGGAGC	0.687000													5	7					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113239370	113239370	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:113239370C>A	ENST00000369644.1	+	15	2961	c.1932C>A	c.(1930-1932)taC>taA	p.Y644*	MOV10_ENST00000413052.2_Nonsense_Mutation_p.Y700*|MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000357443.2_Nonsense_Mutation_p.Y700*|MOV10_ENST00000369645.1_Nonsense_Mutation_p.Y700*			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	700					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		GACTGGGATACTCACTGCTGG	0.597000													5	8					0.000602214	0.000612743	1	1	0
CUBN	8029	broad.mit.edu	37	10	16975190	16975190	+	Missense_Mutation	SNP	G	G	A	rs140202552		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:16975190G>A	ENST00000377833.4	-	40	6085	c.6020C>T	c.(6019-6021)aCg>aTg	p.T2007M		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2007	CUB 14.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GATGAGCCACGTACAGTCCAC	0.532000													12	30					0	0	1	0	0
CLN6	54982	broad.mit.edu	37	15	68510983	68510983	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:68510983C>A	ENST00000249806.5	-	2	246	c.89G>T	c.(88-90)gGc>gTc	p.G30V	CLN6_ENST00000418702.2_5'UTR|RP11-315D16.2_ENST00000562767.1_Intron|CLN6_ENST00000569336.1_5'UTR|CLN6_ENST00000564752.1_Missense_Mutation_p.G30V|CLN6_ENST00000538696.1_Missense_Mutation_p.G62V|CLN6_ENST00000565471.1_Intron|CLN6_ENST00000566347.1_Missense_Mutation_p.G30V	NM_017882.2	NP_060352.1	Q9NWW5	CLN6_HUMAN	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	30					cell death|cholesterol metabolic process|ganglioside metabolic process|glycosaminoglycan metabolic process|lysosomal lumen acidification|positive regulation of proteolysis|protein catabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	protein homodimerization activity			large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GCTCACAGAGCCATGCCTGGG	0.572000													10	22					0.00621372	0.00628055	1	1	0
GATA5	140628	broad.mit.edu	37	20	61048565	61048565	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:61048565G>A	ENST00000252997.2	-	3	654	c.593C>T	c.(592-594)cCg>cTg	p.P198L		NM_080473.4	NP_536721.1	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	198					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			GCGCCACAGCGGTGTGGACAG	0.662000													3	3					0	0	1	0	0
SCD	6319	broad.mit.edu	37	10	102116398	102116398	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:102116398C>T	ENST00000370355.2	+	5	1138	c.757C>T	c.(757-759)Cga>Tga	p.R253*		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	253					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		CACTTTCTTGCGATATGCTGT	0.502000													25	43					0	0	1	0	0
SIDT2	51092	broad.mit.edu	37	11	117052666	117052666	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:117052666G>A	ENST00000324225.4	+	3	980	c.449G>A	c.(448-450)cGc>cAc	p.R150H	SIDT2_ENST00000431081.2_Missense_Mutation_p.R150H|SIDT2_ENST00000530948.1_3'UTR	NM_001040455.1	NP_001035545.1	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2	150						integral to membrane|lysosomal membrane		p.R150H(1)		NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	36	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		CGGGTCAGCCGCATGGACGAT	0.597000													10	8					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139865209	139865209	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:139865209T>C	ENST00000297183.6	+	13	2158	c.2034T>C	c.(2032-2034)ggT>ggC	p.G678G	ANKHD1_ENST00000360839.2_Silent_p.G678G|ANKHD1-EIF4EBP3_ENST00000532219.1_Silent_p.G678G	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCAAAGGGTGGCCATACTA	0.373000													20	38					0	0	1	0	0
RP11-85G18.6	0	broad.mit.edu	37	10	27535727	27535727	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:27535727G>A	ENST00000574842.1	+	0	255																											CTGATCACCTGGGGACGAGAA	0.473000													45	79					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43579557	43579557	+	Missense_Mutation	SNP	G	G	A	rs146901045	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:43579557G>A	ENST00000406487.1	-	3	756	c.658C>T	c.(658-660)Cgg>Tgg	p.R220W		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	220	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region		p.R220W(1)		central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				CCTGAGTTCCGTATTTCACAT	0.507000													14	245					0	0	1	0	0
CDC23	8697	broad.mit.edu	37	5	137533941	137533941	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137533941G>A	ENST00000394886.2	-	9	989	c.959C>T	c.(958-960)gCt>gTt	p.A320V		NM_004661.3	NP_004652.2	Q9UJX2	CDC23_HUMAN	cell division cycle 23	320					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(6)|prostate(2)|skin(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GAGGTTATGAGCCAGATAACT	0.294000													36	78					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36700137	36700137	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:36700137C>T	ENST00000255448.4	-	2	349	c.138G>A	c.(136-138)acG>acA	p.T46T	DCLK1_ENST00000360631.3_Silent_p.T46T|DCLK1_ENST00000379892.4_Silent_p.T46T	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	46			T -> M (in a gastric adenocarcinoma sample; somatic mutation).		cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GCGTCTGCAGCGTGCGGGTGC	0.597000													20	27					0	0	1	0	0
CAST	831	broad.mit.edu	37	5	96011269	96011269	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:96011269G>A	ENST00000395813.1	+	2	288	c.102G>A	c.(100-102)tcG>tcA	p.S34S	CAST_ENST00000338252.3_5'UTR|CAST_ENST00000508830.1_Silent_p.S34S|CAST_ENST00000325674.7_Silent_p.S34S|CAST_ENST00000510756.1_Silent_p.S34S|CAST_ENST00000395812.2_Silent_p.S34S|CAST_ENST00000508608.1_Silent_p.S19S|CAST_ENST00000359176.4_Silent_p.S34S			P20810	ICAL_HUMAN	calpastatin	99							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding	p.?(1)		breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	22		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		CCAGTGAATCGCCTTCCAAAC	0.353000													4	55					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50213386	50213386	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:50213386C>T	ENST00000376025.2	-	0	351							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					ggctctgtggcaggttctggg	0.652000													91	17					0	0	1	0	0
MFN1	55669	broad.mit.edu	37	3	179085366	179085366	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:179085366G>A	ENST00000471841.1	+	8	1019	c.893G>A	c.(892-894)gGg>gAg	p.G298E	MFN1_ENST00000263969.5_Missense_Mutation_p.G298E|MFN1_ENST00000280653.7_Missense_Mutation_p.G298E	NM_033540.2	NP_284941.2	Q8IWA4	MFN1_HUMAN	mitofusin 1	298					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			AAAGCACAGGGGATGCCAGAA	0.403000													18	23					0	0	1	0	0
WNT5B	81029	broad.mit.edu	37	12	1755276	1755276	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:1755276G>A	ENST00000397196.2	+	5	1170	c.938G>A	c.(937-939)gGc>gAc	p.G313D	WNT5B_ENST00000537031.1_Missense_Mutation_p.G313D|WNT5B_ENST00000310594.3_Missense_Mutation_p.G313D|WNT5B_ENST00000545747.1_3'UTR	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	313					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			GGCATGGATGGCTGTGAGCTC	0.637000													25	29					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142643378	142643378	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142643378G>A	ENST00000355265.2	-	11	1704	c.1230C>T	c.(1228-1230)tgC>tgT	p.C410C	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	410					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TCTCCTCCACGCACTTCATCC	0.567000													5	7					0	0	1	0	0
RBM33	155435	broad.mit.edu	37	7	155537713	155537713	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:155537713G>A	ENST00000401878.3	+	14	2594	c.2396G>A	c.(2395-2397)cGc>cAc	p.R799H		NM_053043.2	NP_444271.2	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	799							nucleotide binding|RNA binding			breast(3)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	27	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		GAACAGAAACGCCTAAGAGAA	0.463000													3	7					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90778852	90778852	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:90778852C>T	ENST00000354366.3	-	4	675	c.443G>A	c.(442-444)cGc>cAc	p.R148H	NRDE2_ENST00000357904.3_5'UTR	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		CCAAACAAAGCGATGTCCAGT	0.473000													6	149					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121282370	121282370	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:121282370G>T	ENST00000297848.3	+	26	3440	c.3170G>T	c.(3169-3171)aGc>aTc	p.S1057I	COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000309791.4_Missense_Mutation_p.S1057I|COL14A1_ENST00000247781.3_Missense_Mutation_p.S962I	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1057	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TTTCTATACAGCACTGTTGGA	0.393000													23	42					5.35047e-06	5.54705e-06	1	1	0
PTK2	5747	broad.mit.edu	37	8	141856769	141856769	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:141856769G>A	ENST00000522684.1	-	6	688	c.459C>T	c.(457-459)agC>agT	p.S153S	PTK2_ENST00000340930.3_Silent_p.S153S|PTK2_ENST00000521059.1_Silent_p.S153S|PTK2_ENST00000517887.1_Silent_p.S197S|PTK2_ENST00000519419.1_Silent_p.S197S|PTK2_ENST00000535192.1_Silent_p.S153S|PTK2_ENST00000395218.2_Silent_p.S153S	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	153	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			ACATATAATCGCTCTTCACCT	0.338000													10	30					0	0	1	0	0
DHX33	56919	broad.mit.edu	37	17	5372013	5372013	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:5372013G>A	ENST00000225296.3	-	1	367	c.167C>T	c.(166-168)gCc>gTc	p.A56V	DHX33_ENST00000433302.3_Missense_Mutation_p.A56V	NM_001199699.1|NM_020162.3	NP_001186628.1|NP_064547.2	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	56						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CGAGGGCTGGGCCAGGGGCGG	0.701000													13	15					0	0	1	0	0
NOSIP	0	broad.mit.edu	37	19	50059642	50059642	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50059642G>A	ENST00000391853.3	-	9	917	c.766C>T	c.(766-768)Cgg>Tgg	p.R256W	NOSIP_ENST00000596358.1_Missense_Mutation_p.R256W|NOSIP_ENST00000339093.3_Missense_Mutation_p.R259W	NM_015953.3	NP_057037.1	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	256					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|skin(2)|urinary_tract(1)	11		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		ATGTCCTTCCGAATCAGCTTC	0.622000													15	17					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171482621	171482621	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:171482621C>T	ENST00000176763.5	-	16	2840	c.2497G>A	c.(2497-2499)Gca>Aca	p.A833T		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	833	Gln-rich.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGCTCAGCTGCGCTGCCCCCG	0.652000													10	7					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120574343	120574343	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:120574343G>A	ENST00000300648.6	-	51	6983	c.6971C>T	c.(6970-6972)gCg>gTg	p.A2324V		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	2324					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAGCAGAGCCGCCTTCACATT	0.577000													6	19					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229771763	229771763	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:229771763G>A	ENST00000258243.2	+	4	1539	c.1403G>A	c.(1402-1404)cGg>cAg	p.R468Q		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	468						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						CAAGTGCCACGGTTGTTTGAA	0.557000													8	128					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49158715	49158715	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49158715G>A	ENST00000418109.1	-	33	5505	c.5341C>T	c.(5341-5343)Cgc>Tgc	p.R1781C	LAMB2_ENST00000305544.4_Missense_Mutation_p.R1781C	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1781	Domain I.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGCACGCTGCGCATCCTGGCC	0.582000													14	30					0	0	1	0	0
FOXC2	2303	broad.mit.edu	37	16	86602198	86602198	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:86602198G>A	ENST00000320354.4	+	1	1342	c.1257G>A	c.(1255-1257)gcG>gcA	p.A419A		NM_005251.2	NP_005242.1	Q99958	FOXC2_HUMAN	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	419	Ala/Pro-rich.|Poly-Ala.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	15						ccgccgcggcGCAGGCGGCCT	0.756000									Late-onset Hereditary Lymphedema				5	14					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43870163	43870163	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43870163C>A	ENST00000562955.1	+	4	440	c.440C>A	c.(439-441)cCt>cAt	p.P147H	SZT2_ENST00000310739.4_Missense_Mutation_p.P147H|SZT2_ENST00000372450.4_Missense_Mutation_p.P145H	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	147						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GACTTCCAGCCTGAGATCTAT	0.522000													11	83					3.07112e-06	3.18879e-06	1	1	0
ZNF598	90850	broad.mit.edu	37	16	2049981	2049981	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2049981C>T	ENST00000563630.1	-	9	1646	c.1404G>A	c.(1402-1404)gcG>gcA	p.A468A	ZNF598_ENST00000431526.1_Silent_p.A523A|ZNF598_ENST00000562103.1_Silent_p.A468A			Q86UK7	ZN598_HUMAN	zinc finger protein 598	523						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						CGGTAGCCTGCGCCGAGAGTG	0.692000													3	3					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1244331	1244331	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1244331C>T	ENST00000324642.3	+	10	1462	c.1339C>T	c.(1339-1341)Ctg>Ttg	p.L447L	SLC6A18_ENST00000296821.4_Intron	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	447					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TGCCCCAGGGCTGGTCTGCCT	0.632000													10	46					0	0	1	0	0
VARS2	57176	broad.mit.edu	37	6	30887557	30887557	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30887557G>A	ENST00000321897.5	+	11	1729	c.1097G>A	c.(1096-1098)cGt>cAt	p.R366H	VARS2_ENST00000542001.1_Missense_Mutation_p.R226H|VARS2_ENST00000541562.1_Missense_Mutation_p.R396H|VARS2_ENST00000416670.2_Missense_Mutation_p.R366H			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	366					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						CGACAGCTTCGTCACCCCTTG	0.597000													89	116					0	0	1	0	0
CEP97	79598	broad.mit.edu	37	3	101474433	101474433	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:101474433A>G	ENST00000341893.3	+	7	1640	c.888A>G	c.(886-888)aaA>aaG	p.K296K	CEP97_ENST00000494050.1_Silent_p.K296K|CEP97_ENST00000327230.4_Silent_p.K296K			Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	296						centrosome|nucleus	protein binding			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29						TTTTGAGCAAACAGAGGTAAG	0.433000													3	70					0	0	1	0	0
POFUT1	23509	broad.mit.edu	37	20	30803241	30803241	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:30803241C>T	ENST00000375749.3	+	3	478	c.416C>T	c.(415-417)aCg>aTg	p.T139M	POFUT1_ENST00000375730.3_Missense_Mutation_p.T139M|POFUT1_ENST00000539210.1_Intron|POFUT1_ENST00000486717.1_3'UTR	NM_015352.1	NP_056167.1	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1	139					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|urinary_tract(1)	6			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GATAAGAAGACGTGCCCCATG	0.577000													14	56					0	0	1	0	0
RFPL1	5988	broad.mit.edu	37	22	29837923	29837923	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:29837923G>A	ENST00000354373.2	+	2	975	c.766G>A	c.(766-768)Gtt>Att	p.V256I	RFPL1S_ENST00000461286.2_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	256	B30.2/SPRY.						zinc ion binding			endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						CATGCAGAACGTTTCCTTTTT	0.517000													17	46					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57760065	57760065	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57760065G>A	ENST00000360716.3	+	14	2065	c.1844G>A	c.(1843-1845)cGc>cAc	p.R615H	CCDC135_ENST00000336825.8_Missense_Mutation_p.R550H|CCDC135_ENST00000394337.4_Missense_Mutation_p.R615H			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	615						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						GCGGAGGAGCGCATCCAGCTG	0.632000													7	14					0	0	1	0	0
LRRC37A16P	0	broad.mit.edu	37	17	66130875	66130875	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:66130875C>T	ENST00000590019.1	-	0	298																											ATGGACTTGTCGTAAGATCGG	0.602000													4	5					0	0	1	0	0
FAM101B	359845	broad.mit.edu	37	17	293240	293240	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:293240G>A	ENST00000329099.4	-	2	149	c.150C>T	c.(148-150)gaC>gaT	p.D50D		NM_182705.2	NP_874364.1	Q8N5W9	F101B_HUMAN	family with sequence similarity 101, member B	120								p.D50D(2)		breast(1)|endometrium(3)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)|urinary_tract(1)	13		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.0216)		GCTGCACGTCGTCGATGAAGT	0.657000													22	48					0	0	1	0	0
NCAPG	64151	broad.mit.edu	37	4	17838849	17838849	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:17838849G>T	ENST00000251496.2	+	15	2353	c.2177G>T	c.(2176-2178)aGc>aTc	p.S726I		NM_022346.3	NP_071741.2	Q9BPX3	CND3_HUMAN	non-SMC condensin I complex, subunit G	726					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	27				STAD - Stomach adenocarcinoma(129;0.18)		CTTTTGGTCAGCAGCAGGATT	0.428000													8	66					0.00448238	0.00453641	1	1	0
ABCG2	9429	broad.mit.edu	37	4	89052995	89052995	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:89052995C>T	ENST00000237612.3	-	4	883	c.338G>A	c.(337-339)cGa>cAa	p.R113Q	ABCG2_ENST00000515655.1_Missense_Mutation_p.R113Q	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	113	ABC transporter.				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	ATTGGCAGGTCGCGGTGCTCC	0.393000													14	17					0	0	1	0	0
A4GALT	53947	broad.mit.edu	37	22	43089595	43089595	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:43089595G>A	ENST00000401850.1	-	2	852	c.363C>T	c.(361-363)aaC>aaT	p.N121N	A4GALT_ENST00000249005.2_Silent_p.N121N|A4GALT_ENST00000381278.3_Silent_p.N121N			Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	121					glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			NS(1)|central_nervous_system(2)|large_intestine(6)|skin(1)|urinary_tract(1)	11						GCAGAGAGGCGTTGCCACCCG	0.637000													39	47					0	0	1	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41808629	41808629	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41808629C>T	ENST00000392006.3	+	12	1920	c.1747C>T	c.(1747-1749)Cag>Tag	p.Q583*	HNRNPUL1_ENST00000593587.1_Nonsense_Mutation_p.Q483*|HNRNPUL1_ENST00000378215.4_Nonsense_Mutation_p.Q469*|HNRNPUL1_ENST00000352456.3_Nonsense_Mutation_p.Q483*|HNRNPUL1_ENST00000602130.1_Nonsense_Mutation_p.Q583*|HNRNPUL1_ENST00000263367.3_Nonsense_Mutation_p.Q494*|HNRNPUL1_ENST00000595018.1_Nonsense_Mutation_p.Q483*	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	583	Necessary for interaction with BRD7 and transcriptional activation.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						CATTGAGCTGCAGCGGGAGGA	0.562000													20	29					0	0	1	0	0
PCDHA12	0	broad.mit.edu	37	5	140256125	140256125	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140256125G>A	ENST00000398631.2	+	1	1068	c.1068G>A	c.(1066-1068)tcG>tcA	p.S356S	PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCACTGTCGCTCCCTGTGC	0.517000													16	28					0	0	1	0	0
GPRC5C	0	broad.mit.edu	37	17	72443003	72443003	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72443003G>A	ENST00000392627.1	+	4	2423	c.1297G>A	c.(1297-1299)Gac>Aac	p.D433N	GPRC5C_ENST00000582873.1_3'UTR|GPRC5C_ENST00000342648.5_Missense_Mutation_p.D73N|GPRC5C_ENST00000481232.1_3'UTR|GPRC5C_ENST00000392629.2_Missense_Mutation_p.D400N	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	388						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						AGGAGCTTACGACATCATCCT	0.637000													13	23					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	192011454	192011454	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:192011454G>A	ENST00000392320.2	-	3	472	c.158C>T	c.(157-159)gCa>gTa	p.A53V	STAT4_ENST00000358470.4_Missense_Mutation_p.A53V|STAT4_ENST00000409995.1_Missense_Mutation_p.A53V	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	53					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			AAGAATCGTTGCCATGGTTTC	0.318000													17	17					0	0	1	0	0
MESDC2	23184	broad.mit.edu	37	15	81271611	81271611	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:81271611A>G	ENST00000261758.4	-	3	740	c.654T>C	c.(652-654)tcT>tcC	p.S218S		NM_015154.1	NP_055969.1	Q14696	MESD_HUMAN	mesoderm development candidate 2	218					mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum				cervix(1)|large_intestine(5)|ovary(1)|urinary_tract(1)	8						TGGAAGACCGAGATTTCAGAT	0.507000													14	25					0	0	1	0	0
ZNF646	9726	broad.mit.edu	37	16	31092695	31092695	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31092695C>T	ENST00000394979.2	+	1	5473	c.5050C>T	c.(5050-5052)Cgc>Tgc	p.R1684C	ZNF646_ENST00000300850.5_Missense_Mutation_p.R1684C			O15015	ZN646_HUMAN	zinc finger protein 646	1684					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						CCAGTGCGGGCGCTCCTACCG	0.647000													26	29					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7691458	7691458	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7691458G>A	ENST00000572933.1	+	44	8256	c.6796G>A	c.(6796-6798)Gcc>Acc	p.A2266T	DNAH2_ENST00000389173.2_Missense_Mutation_p.A2266T			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2266	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAAGATGCTGGCCTTTAAGAA	0.552000													6	17					0	0	1	0	0
OR1D5	8386	broad.mit.edu	37	17	2966211	2966211	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:2966211C>A	ENST00000575751.1	-	1	690	c.691G>T	c.(691-693)Gcc>Tcc	p.A231S		NM_014566.1	NP_055381.1	P58170	OR1D5_HUMAN	olfactory receptor, family 1, subfamily D, member 5	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|lung(10)	11						TTCTTAGAGGCCGAGGGCATT	0.507000													5	36					0.0215528	0.0217053	1	1	0
ITIH5	80760	broad.mit.edu	37	10	7608139	7608139	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:7608139G>A	ENST00000256861.6	-	13	2459	c.2381C>T	c.(2380-2382)gCc>gTc	p.A794V	ITIH5_ENST00000446830.2_Missense_Mutation_p.A576V|ITIH5_ENST00000397146.2_Intron|ITIH5_ENST00000298441.6_Missense_Mutation_p.A580V	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	794					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						GGTGACATTGGCGTTGGCAGA	0.597000													8	9					0	0	1	0	0
PDE9A	5152	broad.mit.edu	37	21	44189204	44189204	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:44189204C>T	ENST00000291539.6	+	17	1589	c.1529C>T	c.(1528-1530)gCc>gTc	p.A510V	PDE9A_ENST00000398236.3_Missense_Mutation_p.A424V|PDE9A_ENST00000380328.2_Missense_Mutation_p.A457V|PDE9A_ENST00000335512.4_Missense_Mutation_p.A450V|PDE9A_ENST00000398232.3_Missense_Mutation_p.A443V|PDE9A_ENST00000398227.3_Missense_Mutation_p.A350V|PDE9A_ENST00000349112.3_Missense_Mutation_p.A382V|PDE9A_ENST00000398229.3_Missense_Mutation_p.A376V|PDE9A_ENST00000328862.6_Missense_Mutation_p.A484V|PDE9A_ENST00000398225.3_Missense_Mutation_p.A469V|PDE9A_ENST00000398234.3_Missense_Mutation_p.A409V|PDE9A_ENST00000539837.1_Missense_Mutation_p.A382V|PDE9A_ENST00000398224.3_Missense_Mutation_p.A383V|PDE9A_ENST00000335440.6_Missense_Mutation_p.A408V|PDE9A_ENST00000470987.1_3'UTR	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	510	Catalytic (By similarity).				platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						GTGACCAAGGCCACAGCCCAG	0.507000													11	7					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10610427	10610427	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10610427C>T	ENST00000171111.5	-	2	830	c.283G>A	c.(283-285)Gcc>Acc	p.A95T	KEAP1_ENST00000393623.2_Missense_Mutation_p.A95T	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	95	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ACCTTGTGGGCCATGAACTGG	0.612000													6	10					0	0	1	0	0
C1orf65	164127	broad.mit.edu	37	1	223566990	223566990	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:223566990G>A	ENST00000366875.3	+	1	276	c.173G>A	c.(172-174)tGc>tAc	p.C58Y		NM_152610.2	NP_689823.2	Q8N715	CA065_HUMAN	chromosome 1 open reading frame 65	58										breast(4)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|skin(3)	29				GBM - Glioblastoma multiforme(131;0.0704)		GCTGGGGCGTGCTGGCTGCAC	0.736000													8	8					0	0	1	0	0
FBXO34	55030	broad.mit.edu	37	14	55817903	55817903	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:55817903A>G	ENST00000313833.4	+	2	1040	c.795A>G	c.(793-795)ggA>ggG	p.G265G	FBXO34_ENST00000440021.1_Silent_p.G265G	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	265										breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						CAGAAAGGGGAAATCTTGAGG	0.552000													20	38					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44054509	44054509	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:44054509G>A	ENST00000359947.4	+	8	1127	c.787G>A	c.(787-789)Gtg>Atg	p.V263M	PTPRF_ENST00000372414.3_Missense_Mutation_p.V263M|PTPRF_ENST00000438120.1_Missense_Mutation_p.V263M|PTPRF_ENST00000372413.3_Missense_Mutation_p.V263M	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	263	Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CATGCCCTACGTGAAGTGGAT	0.617000													8	12					0	0	1	0	0
UVSSA	57654	broad.mit.edu	37	4	1348948	1348948	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1348948C>T	ENST00000389851.4	+	7	1538	c.1091C>T	c.(1090-1092)gCc>gTc	p.A364V	UVSSA_ENST00000507531.1_Missense_Mutation_p.A364V|UVSSA_ENST00000511216.1_Missense_Mutation_p.A364V	NM_020894.2	NP_065945.2	Q2YD98	K1530_HUMAN	UV-stimulated scaffold protein A	364																	TTAAAGCGTGCCATTGACCTG	0.627000													3	6					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72776060	72776060	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:72776060C>T	ENST00000299687.5	+	8	6383	c.6383C>T	c.(6382-6384)gCg>gTg	p.A2128V		NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	2128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		ATGCAGGAGGCGCAGGGCGAG	0.647000													3	5					0	0	1	0	0
FBXO6	26270	broad.mit.edu	37	1	11733705	11733705	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11733705G>A	ENST00000376753.4	+	6	814	c.679G>A	c.(679-681)Gtc>Atc	p.V227I		NM_018438.5	NP_060908.1	Q9NRD1	FBX6_HUMAN	F-box protein 6	227	FBA.				DNA damage checkpoint|DNA repair|ER-associated protein catabolic process|response to unfolded protein|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	glycoprotein binding			breast(1)|large_intestine(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(2)	6	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.25e-06)|COAD - Colon adenocarcinoma(227;0.000251)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCCGGGGTGTCCGCTACAT	0.637000													5	54					0	0	1	0	0
MYLPF	29895	broad.mit.edu	37	16	30387747	30387747	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30387747G>A	ENST00000322861.7	+	4	257	c.176G>A	c.(175-177)cGc>cAc	p.R59H		NM_013292.3	NP_037424.2	Q96A32	MLRS_HUMAN	myosin light chain, phosphorylatable, fast skeletal muscle	59	EF-hand 1.				skeletal muscle tissue development	muscle myosin complex	calcium ion binding|structural constituent of muscle			large_intestine(2)|lung(4)	6			Colorectal(24;0.193)			CCTCCAGGCCGCCTCAATGTG	0.577000													9	39					0	0	1	0	0
ZBTB8A	653121	broad.mit.edu	37	1	33058779	33058779	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33058779G>A	ENST00000373510.4	+	3	476	c.247G>A	c.(247-249)Gta>Ata	p.V83I	ZBTB8A_ENST00000316459.4_Missense_Mutation_p.V83I|RP1-27O5.3_ENST00000480336.1_3'UTR	NM_001040441.1	NP_001035531.1	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	83	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(2)|lung(2)|prostate(1)	7						CTTGGACTTCGTATATTCTGG	0.418000													61	65					0	0	1	0	0
IGFALS	3483	broad.mit.edu	37	16	1841078	1841078	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1841078C>T	ENST00000415638.3	-	2	1534	c.1455G>A	c.(1453-1455)acG>acA	p.T485T	IGFALS_ENST00000215539.3_Silent_p.T447T	NM_001146006.1|NM_004970.2	NP_001139478.1|NP_004961.1	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid labile subunit	447					cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding			endometrium(2)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	8						GGGGCAGGTGCGTGAGCTGGT	0.692000													7	19					0	0	1	0	0
NOD1	10392	broad.mit.edu	37	7	30492455	30492455	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:30492455T>A	ENST00000222823.4	-	6	1103	c.578A>T	c.(577-579)gAg>gTg	p.E193V	NOD1_ENST00000423334.2_Missense_Mutation_p.E193V	NM_006092.2	NP_006083.1	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain containing 1	193					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						CTCACCCTGCTCATTGAGGAT	0.622000													20	29					0	0	1	0	0
MICU2	221154	broad.mit.edu	37	13	22069324	22069324	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:22069324T>C	ENST00000382374.4	-	11	1241	c.1176A>G	c.(1174-1176)aaA>aaG	p.K392K	MICU2_ENST00000479790.1_5'UTR	NM_152726.2	NP_689939.1			mitochondrial calcium uptake 2																		GCATTCTGTTTTTTAACACCC	0.313000													18	21					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	108023405	108023405	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:108023405C>T	ENST00000370067.1	+	7	1953	c.1326C>T	c.(1324-1326)tcC>tcT	p.S442S	NTNG1_ENST00000370072.3_Silent_p.S476S|NTNG1_ENST00000370074.4_Silent_p.S420S|NTNG1_ENST00000370061.3_Silent_p.S487S|NTNG1_ENST00000370065.1_Silent_p.S476S|NTNG1_ENST00000370066.1_Silent_p.S462S|NTNG1_ENST00000370073.2_Silent_p.S521S|NTNG1_ENST00000370068.1_Silent_p.S521S|NTNG1_ENST00000370070.2_Silent_p.S442S|NTNG1_ENST00000542803.1_Silent_p.S521S|NTNG1_ENST00000370071.2_Silent_p.S462S			Q9Y2I2	NTNG1_HUMAN	netrin G1	521	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CGCACGGCTCCCCAGCGCTGC	0.721000													4	1					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11913565	11913565	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:11913565G>A	ENST00000339865.5	+	3	967	c.204G>A	c.(202-204)ccG>ccA	p.P68P	USP47_ENST00000527733.1_Silent_p.P136P|USP47_ENST00000539466.1_5'UTR|USP47_ENST00000399455.2_Silent_p.P156P	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	156					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		TTATAGGTCCGCTTCCAAGAG	0.388000													64	73					0	0	1	0	0
KIAA1586	57691	broad.mit.edu	37	6	56915637	56915637	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:56915637C>T	ENST00000370733.4	+	3	378	c.171C>T	c.(169-171)agC>agT	p.S57S	KIAA1586_ENST00000488682.1_3'UTR|KIAA1586_ENST00000545356.1_Intron	NM_020931.2	NP_065982.1	Q9HCI6	K1586_HUMAN	KIAA1586	57							nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)	18	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AAAACCCTAGCGCCTATTATA	0.383000													43	78					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87971050	87971050	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:87971050C>T	ENST00000369577.3	+	8	7746	c.7703C>T	c.(7702-7704)gCt>gTt	p.A2568V	ZNF292_ENST00000339907.4_Missense_Mutation_p.A2563V	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	2568					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GAAGAAACTGCTGTTGCCATT	0.388000													9	12					0	0	1	0	0
C1orf110	339512	broad.mit.edu	37	1	162824960	162824960	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:162824960G>A	ENST00000367912.1	-	4	675	c.501C>T	c.(499-501)gaC>gaT	p.D167D	C1orf110_ENST00000367910.1_Silent_p.D168D|C1orf110_ENST00000524691.1_Intron|C1orf110_ENST00000367911.2_Silent_p.D163D			Q86UF4	CA110_HUMAN	chromosome 1 open reading frame 110	168										endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	12						TGGGGTCTACGTCCTTAGATG	0.463000													8	157					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898725	36898725	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:36898725C>T	ENST00000301807.6	-	12	2603	c.706G>A	c.(706-708)Gat>Aat	p.D236N	TRANK1_ENST00000428977.2_Missense_Mutation_p.D236N|TRANK1_ENST00000429976.2_Missense_Mutation_p.D786N	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	786					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GTCATGTTATCGAAGTCCTGG	0.498000													93	129					0	0	1	0	0
DEGS1	8560	broad.mit.edu	37	1	224377662	224377662	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:224377662G>A	ENST00000323699.4	+	2	632	c.466G>A	c.(466-468)Gct>Act	p.A156T	DEGS1_ENST00000391877.3_Missense_Mutation_p.A156T|DEGS1_ENST00000465848.1_3'UTR	NM_003676.3	NP_003667.1	O15121	DEGS1_HUMAN	delta(4)-desaturase, sphingolipid 1	156					sphingolipid metabolic process|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	electron carrier activity|protein binding|sphingolipid delta-4 desaturase activity			breast(1)|kidney(3)|large_intestine(2)|lung(4)	10	Breast(184;0.193)			GBM - Glioblastoma multiforme(131;0.00643)		CTTCTGTACCGCTTTCAGAAA	0.423000													61	85					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179577222	179577222	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179577222C>T	ENST00000589042.1	-	95	27651	c.27427G>A	c.(27427-27429)Gtt>Att	p.V9143I	TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.V8826I|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.V7899I|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8826	Ig-like 74.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCAGGTAACCGAAATGGGA	0.428000													17	22					0	0	1	0	0
GJC2	57165	broad.mit.edu	37	1	228345726	228345726	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228345726G>A	ENST00000366714.2	+	2	442	c.267G>A	c.(265-267)acG>acA	p.T89T		NM_020435.3	NP_065168.2	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	89					cell death	connexon complex|integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Prostate(94;0.0405)				TCATCTCCACGCCCTCGGTCA	0.716000													9	19					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27448161	27448161	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27448161G>A	ENST00000527372.1	-	6	1620	c.1440C>T	c.(1438-1440)acC>acT	p.T480T	MYO18A_ENST00000354329.4_Silent_p.T480T|MYO18A_ENST00000533112.1_Silent_p.T480T|MYO18A_ENST00000531253.1_Silent_p.T480T	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	480	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CCCTGTATGCGGTCTGGGCCA	0.587000													5	9					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207173107	207173107	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:207173107A>G	ENST00000374423.3	+	5	4241	c.3855A>G	c.(3853-3855)atA>atG	p.I1285M		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1285							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						ATTCCAGAATAAATTTTGATT	0.393000													4	44					0	0	1	0	0
TRABD	80305	broad.mit.edu	37	22	50636541	50636541	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50636541C>T	ENST00000303434.4	+	9	1001	c.882C>T	c.(880-882)ggC>ggT	p.G294G	TRABD_ENST00000395829.1_Silent_p.G294G|TRABD_ENST00000380909.4_Silent_p.G294G|TRABD_ENST00000395827.1_Silent_p.G294G	NM_025204.2	NP_079480.2	Q9H4I3	TRABD_HUMAN	TraB domain containing	294										breast(1)|central_nervous_system(1)|large_intestine(1)|liver(2)|lung(1)|upper_aerodigestive_tract(1)	7		all_cancers(38;1.07e-07)|all_epithelial(38;9.6e-07)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		LUAD - Lung adenocarcinoma(64;0.105)		TGGTCGTGGGCGTCGTGGGCA	0.667000													10	10					0	0	1	0	0
PSMB9	5698	broad.mit.edu	37	6	32826307	32826307	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32826307C>T	ENST00000453265.2	+	4	494	c.425C>T	c.(424-426)cCt>cTt	p.P142L	PSMB9_ENST00000395330.1_Intron|PSMB9_ENST00000374859.2_Intron			P28065	PSB9_HUMAN	proteasome (prosome, macropain) subunit, beta type, 9	0					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			large_intestine(4)|lung(4)|skin(1)	9						GGAAGGGTACCTGGGGAGGGC	0.498000													10	20					0	0	1	0	0
VPS16	64601	broad.mit.edu	37	20	2845812	2845812	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:2845812C>T	ENST00000380445.3	+	21	2095	c.2023C>T	c.(2023-2025)Cgg>Tgg	p.R675W	VPS16_ENST00000380443.3_Missense_Mutation_p.R361W|PTPRA_ENST00000380393.3_5'UTR|VPS16_ENST00000380469.3_Missense_Mutation_p.R531W	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	675					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						GGATCAAATGCGGCTCCTACG	0.582000													18	38					0	0	1	0	0
TARS	6897	broad.mit.edu	37	5	33467737	33467737	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:33467737G>A	ENST00000265112.3	+	19	2407	c.2096G>A	c.(2095-2097)cGc>cAc	p.R699H	TARS_ENST00000414361.2_Missense_Mutation_p.R578H|TARS_ENST00000541634.1_Missense_Mutation_p.R595H|TARS_ENST00000455217.2_Missense_Mutation_p.R732H|TARS_ENST00000502553.1_Missense_Mutation_p.R699H	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	699					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	CACGGGGAACGCACCATTTCT	0.423000													19	27					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177036997	177036997	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:177036997C>A	ENST00000468418.3	+	4	3384	c.1294C>A	c.(1294-1296)Ctg>Atg	p.L432M	HOXD3_ENST00000249440.3_Missense_Mutation_p.L432M|HOXD3_ENST00000410016.1_Missense_Mutation_p.L432M			P31249	HXD3_HUMAN	homeobox D3	432					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		ACTGACGCATCTGTAGCGGCC	0.647000													6	14					0.0293803	0.0295506	1	1	0
DNAJB8	165721	broad.mit.edu	37	3	128181497	128181497	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:128181497G>A	ENST00000469083.1	-	2	3149	c.592C>T	c.(592-594)Cgc>Tgc	p.R198C	DNAJB8_ENST00000319153.3_Missense_Mutation_p.R198C			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	198					protein folding		heat shock protein binding|unfolded protein binding	p.R198C(1)		kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		TCCACGATGCGCTTGGTGGTG	0.602000													26	37					0	0	1	0	0
SCAMP2	10066	broad.mit.edu	37	15	75146410	75146410	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75146410C>T	ENST00000268099.9	-	3	286	c.177G>A	c.(175-177)caG>caA	p.Q59Q		NM_005697.3	NP_005688.2	O15127	SCAM2_HUMAN	secretory carrier membrane protein 2	59					post-Golgi vesicle-mediated transport|protein transport	integral to membrane|nucleus|recycling endosome membrane|trans-Golgi network membrane	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	9						GAACCGCTGGCTGTGAGGACC	0.527000													15	17					0	0	1	0	0
DLL1	28514	broad.mit.edu	37	6	170594702	170594702	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:170594702G>A	ENST00000366756.3	-	6	1150	c.817C>T	c.(817-819)Cag>Tag	p.Q273*		NM_005618.3	NP_005609.3	O00548	DLL1_HUMAN	delta-like 1 (Drosophila)	273	EGF-like 2.				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			NS(2)|breast(1)|endometrium(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	33		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CAGTTGCACTGCCAGGGCTGC	0.627000													20	23					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99640796	99640796	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:99640796G>A	ENST00000345514.2	-	3	2430	c.2164C>T	c.(2164-2166)Cgc>Tgc	p.R722C	BCL11B_ENST00000357195.3_Missense_Mutation_p.R793C|BCL11B_ENST00000443726.2_Missense_Mutation_p.R599C	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	793						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		TCGCTGCGGCGGCCCTCCTTG	0.736000			T	TLX3	T-ALL								5	3					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32272191	32272191	+	Missense_Mutation	SNP	C	C	T	rs147817091	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:32272191C>T	ENST00000400246.1	+	37	3887	c.3745C>T	c.(3745-3747)Cgg>Tgg	p.R1249W	DEPDC5_ENST00000266091.3_Missense_Mutation_p.R1227W|DEPDC5_ENST00000535622.1_Missense_Mutation_p.R1149W|DEPDC5_ENST00000400248.1_Missense_Mutation_p.R1218W|DEPDC5_ENST00000382105.2_Intron|DEPDC5_ENST00000382111.2_Missense_Mutation_p.R1249W|DEPDC5_ENST00000539165.1_Missense_Mutation_p.R66W|DEPDC5_ENST00000382112.3_Missense_Mutation_p.R1240W|DEPDC5_ENST00000400249.2_Missense_Mutation_p.R1218W			O75140	DEPD5_HUMAN	DEP domain containing 5	1218					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CGAAGCCTGGCGGACCTTCAT	0.517000													41	76					0	0	1	0	0
CDC37	11140	broad.mit.edu	37	19	10505948	10505948	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10505948C>A	ENST00000222005.2	-	4	612	c.559G>T	c.(559-561)Gcc>Tcc	p.A187S		NM_007065.3	NP_008996.1	Q16543	CDC37_HUMAN	cell division cycle 37	187					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	16			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		AGGTAATTGGCTGTCTCCTCG	0.577000													9	155					3.86212e-05	3.97146e-05	1	1	0
RANBP3	8498	broad.mit.edu	37	19	5925679	5925679	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5925679C>T	ENST00000340578.6	-	10	940	c.883G>A	c.(883-885)Gca>Aca	p.A295T	RANBP3_ENST00000591092.1_Missense_Mutation_p.A222T|RANBP3_ENST00000541471.1_Missense_Mutation_p.A167T|RANBP3_ENST00000034275.8_Missense_Mutation_p.A227T|RANBP3_ENST00000439268.2_Missense_Mutation_p.A290T	NM_003624.2|NM_007320.2|NM_007322.2	NP_003615.2|NP_015559.2|NP_015561.1	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3	295					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	18						TAGTTCGTTGCGGTTGGCGTG	0.587000													16	63					0	0	1	0	0
PI4KB	5298	broad.mit.edu	37	1	151278675	151278675	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151278675C>T	ENST00000368875.2	-	6	1963	c.1383G>A	c.(1381-1383)gtG>gtA	p.V461V	PI4KB_ENST00000368873.1_Silent_p.V449V|PI4KB_ENST00000529142.1_Silent_p.V117V|PI4KB_ENST00000271657.5_Silent_p.V461V|PI4KB_ENST00000368872.1_Silent_p.V434V|PI4KB_ENST00000368874.4_Silent_p.V434V	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	449					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CATAGTTGGGCACAGTGCTGA	0.567000													30	37					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36698503	36698503	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:36698503T>C	ENST00000399881.3	+	16	1722	c.1685T>C	c.(1684-1686)cTc>cCc	p.L562P		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	562						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TACAAGTCCCTCTTTACGGAT	0.403000													11	19					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66620277	66620277	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66620277G>A	ENST00000393960.1	-	14	1825	c.1544C>T	c.(1543-1545)cCg>cTg	p.P515L	PC_ENST00000393955.2_Missense_Mutation_p.P515L|PC_ENST00000393958.2_Missense_Mutation_p.P515L	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	515					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GACGGGAATCGGGGTGGTTGG	0.627000													7	30					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5541110	5541110	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:5541110C>T	ENST00000382368.3	-	3	913	c.790G>A	c.(790-792)Gcc>Acc	p.A264T	FBXL18_ENST00000453700.3_Missense_Mutation_p.A264T	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	264									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		ATGAGGAAGGCGTGGAGGTTC	0.652000													12	12					0	0	1	0	0
TOR4A	54863	broad.mit.edu	37	9	140173475	140173475	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140173475C>T	ENST00000357503.2	+	2	530	c.334C>T	c.(334-336)Cgc>Tgc	p.R112C		NM_017723.2	NP_060193.2	Q9NXH8	CI167_HUMAN	torsin family 4, member A	112					chaperone mediated protein folding requiring cofactor	integral to membrane	ATP binding|nucleoside-triphosphatase activity										GTATCGGCCGCGCGTGGAGCA	0.662000													3	7					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113323358	113323358	+	Silent	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:113323358T>A	ENST00000297405.5	-	50	7978	c.7734A>T	c.(7732-7734)ggA>ggT	p.G2578G	CSMD3_ENST00000343508.3_Silent_p.G2538G|CSMD3_ENST00000352409.3_Silent_p.G2508G|CSMD3_ENST00000455883.2_Silent_p.G2474G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2578	Sushi 14.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGATAATATATCCATGAGGTG	0.408000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			39	32					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61982381	61982381	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:61982381T>C	ENST00000370263.4	-	5	605		c.e5-2		CHRNA4_ENST00000463705.1_Splice_Site	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)						B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CCGTCAGCACTGGGCAGGAAG	0.652000													3	11					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43720314	43720314	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43720314C>T	ENST00000263801.3	-	18	3965	c.3713G>A	c.(3712-3714)cGt>cAt	p.R1238H	TP53BP1_ENST00000450115.2_Missense_Mutation_p.R1243H|TP53BP1_ENST00000382039.3_Missense_Mutation_p.R1243H|TP53BP1_ENST00000382044.4_Missense_Mutation_p.R1243H	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	1238					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TCTCATGTGACGATGTAAGAC	0.438000								Other conserved DNA damage response genes					46	54					0	0	1	0	0
OR6C65	403282	broad.mit.edu	37	12	55795143	55795143	+	Silent	SNP	C	C	A	rs138141433		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:55795143C>A	ENST00000379665.2	+	1	930	c.831C>A	c.(829-831)acC>acA	p.T277T		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						TGCTTAATACCTCTGTTGCTC	0.368000													14	31					4.36969e-10	4.65946e-10	1	1	0
MSH6	2956	broad.mit.edu	37	2	48026577	48026577	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:48026577G>A	ENST00000234420.4	+	4	1607	c.1455G>A	c.(1453-1455)caG>caA	p.Q485Q	MSH6_ENST00000538136.1_Silent_p.Q183Q|MSH6_ENST00000540021.1_Silent_p.Q355Q|FBXO11_ENST00000405808.1_Intron	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	485					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GAGTGGAACAGACTGAGACTC	0.463000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				21	20					0	0	1	0	0
SERTAD4	56256	broad.mit.edu	37	1	210415061	210415061	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:210415061C>T	ENST00000367012.3	+	4	680	c.450C>T	c.(448-450)tgC>tgT	p.C150C	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	150							protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		ATAACTGGTGCTTCCCTGCCT	0.453000													34	51					0	0	1	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135098974	135098974	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:135098974C>T	ENST00000368563.2	-	12	2237	c.1881G>A	c.(1879-1881)tcG>tcA	p.S627S	TUBGCP2_ENST00000252936.3_Silent_p.S627S|TUBGCP2_ENST00000368562.1_Silent_p.S220S|TUBGCP2_ENST00000543663.1_Silent_p.S655S|TUBGCP2_ENST00000417178.2_Silent_p.S497S	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	627					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		TGATGATGAGCGAAAGGGGCC	0.637000													5	4					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10307651	10307651	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:10307651T>C	ENST00000403437.2	-	22	2778	c.2684A>G	c.(2683-2685)cAa>cGa	p.Q895R	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	895					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						ACTCACAGATTGAACCTGGAG	0.373000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				11	57					0	0	1	0	0
GLTSCR2	29997	broad.mit.edu	37	19	48259855	48259855	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:48259855G>T	ENST00000246802.5	+	11	1405	c.1367G>T	c.(1366-1368)aGa>aTa	p.R456I	GLTSCR2_ENST00000598681.1_3'UTR	NM_015710.4	NP_056525.2	Q9NZM5	GSCR2_HUMAN	glioma tumor suppressor candidate region gene 2	456				EGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFR EIQL -> RGQHSFETGSRAFRGGI (in Ref. 3; AAG30413).|PEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAF REIQ -> VLTVSCRGAPCPVMTPSLLPVPPRGYGRHHGCP WAGPVGPMPRG (in Ref. 5).		nucleolus				central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	15		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)		CCTCGAGAGAGAGCCAAGTAA	0.617000													8	18					0.000274275	0.000279654	1	1	0
OR51D1	390038	broad.mit.edu	37	11	4661076	4661076	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:4661076T>C	ENST00000357605.2	+	1	132	c.56T>C	c.(55-57)gTc>gCc	p.V19A		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGAAATCTGGTCCACGCAGCA	0.488000													13	117					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26856412	26856412	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:26856412T>A	ENST00000376236.4	+	15	2451	c.1996T>A	c.(1996-1998)Tcc>Acc	p.S666T		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	666					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						AGGCAACGTGTCCTAGGGACG	0.552000													12	7					0	0	1	0	0
DHX15	1665	broad.mit.edu	37	4	24544563	24544563	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:24544563C>T	ENST00000336812.4	-	7	1491	c.1335_splice	c.e7+1	p.K445_splice		NM_001358.2	NP_001349.2	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 15	445	Helicase C-terminal.				mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	30		Breast(46;0.0503)				AAATATGTACCTTCTGTTTCG	0.328000													21	44					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155098657	155098657	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:155098657C>T	ENST00000392825.3	+	5	993	c.426C>T	c.(424-426)tcC>tcT	p.S142S	GALNT13_ENST00000409237.1_Silent_p.S142S	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	142	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						TAAATCGTTCCCCACACTATC	0.373000													11	29					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186536198	186536198	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:186536198C>T	ENST00000431808.1	-	17	3318		c.e17+1		SORBS2_ENST00000437304.2_Splice_Site|SORBS2_ENST00000284776.7_Splice_Site|SORBS2_ENST00000393528.3_Splice_Site|SORBS2_ENST00000319471.9_Splice_Site|SORBS2_ENST00000498125.1_Splice_Site|SORBS2_ENST00000355634.5_Splice_Site|SORBS2_ENST00000418609.1_Splice_Site|SORBS2_ENST00000449407.2_Splice_Site|SORBS2_ENST00000448662.2_Splice_Site			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2							actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		AGAGGACCTACCTCTACGTAT	0.458000													10	35					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47851715	47851715	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:47851715C>T	ENST00000359568.5	+	38	8444	c.8337C>T	c.(8335-8337)tgC>tgT	p.C2779C	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2779					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding	p.C2779C(1)		NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AGGAGGCTTGCGTGCACCAGG	0.627000													5	6					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61537762	61537762	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61537762G>A	ENST00000278836.5	+	5	601	c.505G>A	c.(505-507)Gtg>Atg	p.V169M	TMEM258_ENST00000535042.1_Intron|MYRF_ENST00000265460.5_Missense_Mutation_p.V160M	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		ACTGTGCCACGTGGGAGTGCC	0.687000													6	5					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120348948	120348948	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:120348948C>T	ENST00000397843.2	+	37	3782	c.3616C>T	c.(3616-3618)Cgt>Tgt	p.R1206C	ARHGEF12_ENST00000532993.1_Missense_Mutation_p.R1103C|ARHGEF12_ENST00000356641.3_Missense_Mutation_p.R1187C	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1206					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ATCAGAGGTACGTGATCTGTT	0.413000			T	MLL	AML								31	48					0	0	1	0	0
OGDH	4967	broad.mit.edu	37	7	44685060	44685060	+	Silent	SNP	C	C	T	rs116191385	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44685060C>T	ENST00000222673.5	+	3	399	c.357C>T	c.(355-357)aaC>aaT	p.N119N	OGDH_ENST00000439616.2_Intron|OGDH_ENST00000443864.2_Silent_p.N119N|OGDH_ENST00000444676.1_Silent_p.N119N|OGDH_ENST00000447398.1_Silent_p.N119N|OGDH_ENST00000543843.1_Silent_p.N59N|OGDH_ENST00000449767.1_Silent_p.N119N	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	119					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	CACAGCCCAACGTGGACAAGC	0.637000													13	15					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182542533	182542533	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:182542533G>A	ENST00000295108.3	-	2	1512	c.1055C>T	c.(1054-1056)gCc>gTc	p.A352V	CERKL_ENST00000479558.1_Intron|NEUROD1_ENST00000496876.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	352					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ATGAAATATGGCATTGAGCTG	0.507000													55	96					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50783375	50783375	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50783375G>T	ENST00000440075.2	+	31	4161	c.4114G>T	c.(4114-4116)Gaa>Taa	p.E1372*	MYH14_ENST00000425460.1_Nonsense_Mutation_p.E1339*|MYH14_ENST00000376970.2_Nonsense_Mutation_p.E1364*|MYH14_ENST00000262269.8_Nonsense_Mutation_p.E1372*|MYH14_ENST00000601313.1_Nonsense_Mutation_p.E1372*|MYH14_ENST00000598205.1_Nonsense_Mutation_p.E1339*|MYH14_ENST00000596571.1_Nonsense_Mutation_p.E1331*			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1331					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GAGCAGCACAGAAGCCCAGCT	0.622000													6	4					0.0293803	0.0295506	1	1	0
TET3	200424	broad.mit.edu	37	2	74300738	74300738	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74300738G>A	ENST00000409262.3	+	2	2152	c.2152G>A	c.(2152-2154)Gcc>Acc	p.A718T		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	718							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCCCACGGTCGCCTCTATCCG	0.448000													5	9					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96612526	96612526	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:96612526T>A	ENST00000371321.3	+	9	1410	c.1328T>A	c.(1327-1329)aTg>aAg	p.M443K	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	443					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CTGGCCCGCATGGAGCTGTTT	0.428000													38	70					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25932771	25932771	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:25932771G>A	ENST00000398988.3	+	16	2026	c.1581G>A	c.(1579-1581)acG>acA	p.T527T	KSR1_ENST00000319524.6_Silent_p.T664T|KSR1_ENST00000509603.2_Silent_p.T642T|KSR1_ENST00000268763.6_Silent_p.T527T	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	662					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		ACCGGCAGACGCGGCATGAGA	0.597000													12	11					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77292662	77292662	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:77292662G>A	ENST00000388914.3	-	9	1209	c.1057C>T	c.(1057-1059)Ctt>Ttt	p.L353F		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	353										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						GAGTTGGCAAGGACTAACTGC	0.383000													22	41					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156918644	156918644	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:156918644T>C	ENST00000257527.4	-	18	2152	c.2074A>G	c.(2074-2076)Agt>Ggt	p.S692G	ADAM19_ENST00000394020.1_Missense_Mutation_p.S694G|ADAM19_ENST00000517905.1_Missense_Mutation_p.S692G|ADAM19_ENST00000430702.2_Missense_Mutation_p.S425G	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	692					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATAGGCCCACTGTCGATACTG	0.637000													7	7					0	0	1	0	0
CUL1	8454	broad.mit.edu	37	7	148427245	148427245	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:148427245G>A	ENST00000325222.4	+	2	310	c.31G>A	c.(31-33)Ggc>Agc	p.G11S	CUL1_ENST00000602748.1_Missense_Mutation_p.G11S|CUL1_ENST00000409469.1_Missense_Mutation_p.G11S	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	11					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GAACCCCCACGGCCTGAAGCA	0.532000													32	37					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30922042	30922042	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:30922042T>C	ENST00000597505.1	-	31	4504	c.4505A>G	c.(4504-4506)aAt>aGt	p.N1502S	DCDC1_ENST00000406071.2_Missense_Mutation_p.N240S|DCDC1_ENST00000339794.5_Missense_Mutation_p.N581S			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					CATTCTTGGATTTTCTGGTGG	0.279000													6	12					0	0	1	0	0
PCIF1	63935	broad.mit.edu	37	20	44576010	44576010	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:44576010C>T	ENST00000372409.3	+	16	2180	c.1816C>T	c.(1816-1818)Cgc>Tgc	p.R606C	PCIF1_ENST00000479348.1_3'UTR	NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	606						nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						CCGCTTCAAACGCCACCAGTT	0.622000													9	10					0	0	1	0	0
LINC00471	0	broad.mit.edu	37	2	232374032	232374032	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:232374032C>T	ENST00000313064.2	-	0	386					NR_024079.1																						ATTCTTCCTGCAATTCTTATG	0.473000													7	31					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027856	37027856	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:37027856G>A	ENST00000358047.3	+	1	1425	c.1373G>A	c.(1372-1374)cGg>cAg	p.R458Q		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	458										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CCCAAGACTCGGGTGTCCAGT	0.632000													47	7					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32207730	32207730	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32207730G>A	ENST00000373658.3	-	8	1682	c.1341C>T	c.(1339-1341)agC>agT	p.S447S	BAI2_ENST00000398538.1_Silent_p.S435S|BAI2_ENST00000527361.1_Silent_p.S447S|BAI2_ENST00000373655.2_Silent_p.S447S|BAI2_ENST00000398542.1_Silent_p.S380S|BAI2_ENST00000440175.2_Silent_p.S89S|BAI2_ENST00000398556.3_Silent_p.S395S|BAI2_ENST00000398547.1_Silent_p.S380S|BAI2_ENST00000257070.4_Silent_p.S447S	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	447	TSP type-1 3.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GGCCCGCCACGCTGCACTTCC	0.672000													6	20					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176719086	176719086	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176719086C>T	ENST00000439151.2	+	22	6435	c.6390C>T	c.(6388-6390)ctC>ctT	p.L2130L	NSD1_ENST00000361032.4_Silent_p.L2027L|NSD1_ENST00000354179.4_Silent_p.L1861L|NSD1_ENST00000347982.4_Silent_p.L1861L	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2130					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CTGGCCAGCTCGTCTCCTGCA	0.507000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			10	17					0	0	1	0	0
TIRAP	114609	broad.mit.edu	37	11	126162649	126162649	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:126162649C>T	ENST00000392679.1	+	4	628	c.345C>T	c.(343-345)cgC>cgT	p.R115R	TIRAP_ENST00000392678.3_Silent_p.R115R|TIRAP_ENST00000392680.2_Silent_p.R115R			P58753	TIRAP_HUMAN	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	115	TIR.				3'-UTR-mediated mRNA stabilization|cellular response to bacterial lipopeptide|cellular response to lipoteichoic acid|defense response to Gram-positive bacterium|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|myeloid cell differentiation|negative regulation of growth of symbiont in host|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 1 production|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of ERK1 and ERK2 cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-12 production|positive regulation of interleukin-15 production|positive regulation of interleukin-6 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of JNK cascade|positive regulation of neutrophil chemotaxis|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein homodimerization activity|positive regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|regulation of interferon-beta production|response to lipopolysaccharide|TIRAP-dependent toll-like receptor 4 signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway	endocytic vesicle|intrinsic to membrane|ruffle membrane	phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|protein heterodimerization activity|protein homodimerization activity|protein kinase C delta binding|Toll-like receptor 2 binding|Toll-like receptor 4 binding|transmembrane receptor activity			breast(1)|endometrium(1)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	6	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0739)		CCAGCCTGCGCTGCTTCCTGC	0.627000													5	9					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58562607	58562607	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:58562607T>C	ENST00000348616.4	+	8	1237	c.937T>C	c.(937-939)Ttc>Ctc	p.F313L	CDH26_ENST00000244047.5_Missense_Mutation_p.F313L	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	313	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GAGAGCAAAATTCAACATATT	0.458000													24	35					0	0	1	0	0
GSN	2934	broad.mit.edu	37	9	124094730	124094730	+	Missense_Mutation	SNP	C	C	T	rs142854368		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:124094730C>T	ENST00000373823.3	+	25	2950	c.2045C>T	c.(2044-2046)aCg>aTg	p.T682M	GSN_ENST00000373818.4_Missense_Mutation_p.T733M|GSN_ENST00000545652.1_Missense_Mutation_p.T690M|GSN_ENST00000373808.2_Missense_Mutation_p.T682M|GSN_ENST00000412819.1_Missense_Mutation_p.T682M|GSN_ENST00000449733.1_Missense_Mutation_p.T682M|GSN_ENST00000373806.1_Missense_Mutation_p.T158M|GSN_ENST00000341272.2_Missense_Mutation_p.T682M|GSN_ENST00000436847.1_Missense_Mutation_p.T693M|GSN_ENST00000394353.2_Missense_Mutation_p.T693M			P06396	GELS_HUMAN	gelsolin	733	Actin-binding, Ca-sensitive (Potential).				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						TACATCGAGACGGACCCAGCC	0.577000											OREG0019445	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	20					0	0	1	0	0
PER1	5187	broad.mit.edu	37	17	8052891	8052891	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8052891C>T	ENST00000317276.4	-	6	979	c.742G>A	c.(742-744)Gtg>Atg	p.V248M	PER1_ENST00000354903.5_Missense_Mutation_p.V232M|PER1_ENST00000581082.1_Missense_Mutation_p.V228M	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	248	PAS 1.				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CCCCGGAACACGTCCCGCTTG	0.622000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					13	20					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72344288	72344288	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:72344288G>A	ENST00000299687.5	+	1	1313	c.1313G>A	c.(1312-1314)gGc>gAc	p.G438D	ZNF407_ENST00000577538.1_Missense_Mutation_p.G438D|ZNF407_ENST00000309902.6_Missense_Mutation_p.G438D|ZNF407_ENST00000582337.1_Missense_Mutation_p.G438D	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		ACCTTGAAGGGCCAGGCAAAG	0.428000													11	34					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114165511	114165511	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:114165511G>A	ENST00000369615.1	+	9	1317	c.1255G>A	c.(1255-1257)Gga>Aga	p.G419R	MAGI3_ENST00000369617.4_Missense_Mutation_p.G444R|MAGI3_ENST00000307546.9_Missense_Mutation_p.G419R|MAGI3_ENST00000369611.4_Missense_Mutation_p.G419R	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	444					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGCACAATGGGATTTGGTTT	0.413000													10	18					0	0	1	0	0
TNK2	10188	broad.mit.edu	37	3	195594514	195594514	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195594514C>A	ENST00000333602.6	-	12	3227	c.2610G>T	c.(2608-2610)gaG>gaT	p.E870D	TNK2_ENST00000381916.2_Missense_Mutation_p.E948D|TNK2_ENST00000428187.1_Missense_Mutation_p.E902D|TNK2_ENST00000392400.1_Missense_Mutation_p.E870D	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	870	EBD domain (By similarity).|Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GCTGGTAGCGCTCCAGGTAGG	0.697000													6	17					0.248553	0.248844	1	1	0
BMP1	649	broad.mit.edu	37	8	22053008	22053008	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22053008G>A	ENST00000306385.5	+	13	2343	c.1673G>A	c.(1672-1674)gGc>gAc	p.G558D	BMP1_ENST00000397816.3_Missense_Mutation_p.G558D|BMP1_ENST00000354870.5_3'UTR|BMP1_ENST00000397814.3_Missense_Mutation_p.G558D|BMP1_ENST00000306349.8_Missense_Mutation_p.G558D	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	558	EGF-like 1; calcium-binding (Potential).				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		AACCGCGGGGGCTGTGAGCAG	0.642000													14	28					0	0	1	0	0
MNX1	3110	broad.mit.edu	37	7	156798500	156798500	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:156798500G>A	ENST00000252971.6	-	3	1220	c.920C>T	c.(919-921)gCg>gTg	p.A307V	MNX1_ENST00000543409.1_Missense_Mutation_p.A95V|MNX1_ENST00000469500.1_Intron	NM_005515.3	NP_005506.3	P50219	MNX1_HUMAN	motor neuron and pancreas homeobox 1	307					humoral immune response|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(4)|skin(1)	7	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCTTCCTGCGCCGCCTGCTC	0.687000													27	57					0	0	1	0	0
KCNN2	3781	broad.mit.edu	37	5	113740489	113740489	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:113740489G>A	ENST00000512097.3	+	4	1955	c.937G>A	c.(937-939)Gta>Ata	p.V313I	KCNN2_ENST00000264773.3_Missense_Mutation_p.V313I|KCNN2_ENST00000507750.1_Intron			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	313						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CCCAGGAACTGTACTCTTGGT	0.368000													48	62					0	0	1	0	0
ZNF81	347344	broad.mit.edu	37	X	47774323	47774323	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:47774323A>G	ENST00000376954.1	+	6	646	c.277_splice	c.e6-1	p.D93_splice	ZNF81_ENST00000338637.7_Splice_Site_p.D93_splice			P51508	ZNF81_HUMAN	zinc finger protein 81	93						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(1)|lung(1)|skin(1)	4		all_lung(315;0.0973)				CTCTTTTTAGATGGGAAATTT	0.338000													23	6					0	0	1	0	0
SERAC1	84947	broad.mit.edu	37	6	158571515	158571515	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:158571515T>G	ENST00000367102.2	-	4	376	c.235A>C	c.(235-237)Aca>Cca	p.T79P	SERAC1_ENST00000367101.1_Missense_Mutation_p.T79P|SERAC1_ENST00000367104.3_Missense_Mutation_p.T79P|SERAC1_ENST00000607000.1_Missense_Mutation_p.T79P			Q96JX3	SRAC1_HUMAN	serine active site containing 1	79					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds			endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	15		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		AAAGAAACTGTGTGCACATAT	0.323000													15	31					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40342635	40342635	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:40342635C>T	ENST00000406785.1	-	8	2761	c.2572G>A	c.(2572-2574)Gca>Aca	p.A858T	SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1_ENST00000542756.1_Missense_Mutation_p.A889T|SLC8A1_ENST00000542024.1_Missense_Mutation_p.A858T|SLC8A1_ENST00000406391.2_Missense_Mutation_p.A858T|SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1_ENST00000405269.1_Missense_Mutation_p.A858T|SLC8A1_ENST00000402441.1_Missense_Mutation_p.A858T|SLC8A1_ENST00000408028.2_Missense_Mutation_p.A886T|SLC8A1_ENST00000332839.4_Missense_Mutation_p.A894T|SLC8A1_ENST00000403092.1_Missense_Mutation_p.A894T|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1_ENST00000405901.3_Missense_Mutation_p.A889T			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	894					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CCATTGGCTGCGTGGTAGATG	0.542000													11	17					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78293254	78293254	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78293254G>A	ENST00000319921.4	+	17	3307	c.3166G>A	c.(3166-3168)Gcc>Acc	p.A1056T	RNF213_ENST00000456466.1_Intron|RNF213_ENST00000582970.1_Intron|RNF213_ENST00000508628.2_Intron	NM_020954.3	NP_066005.2	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CTCCTCCCTCGCCAAGGGCAA	0.572000													16	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179446516	179446516	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179446516G>A	ENST00000589042.1	-	316	66703	c.66479C>T	c.(66478-66480)cCg>cTg	p.P22160L	TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P13287L|TTN_ENST00000591111.1_Missense_Mutation_p.P20519L|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P13095L|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P19592L|TTN_ENST00000359218.5_Missense_Mutation_p.P13220L|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20519	Fibronectin type-III 60.		V -> I.				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGGAAAGCCGGTGGGCCAGG	0.448000													6	16					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57268766	57268766	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57268766C>T	ENST00000278426.3	-	3	546	c.191G>A	c.(190-192)cGc>cAc	p.R64H	SLC43A1_ENST00000528450.1_Missense_Mutation_p.R64H	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	64					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						TGGCCACCTGCGCTGCTCATC	0.627000													9	51					0	0	1	0	0
GYS1	2997	broad.mit.edu	37	19	49490492	49490492	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49490492C>T	ENST00000323798.3	-	3	647	c.451G>A	c.(451-453)Gct>Act	p.A151T	GYS1_ENST00000544287.1_Intron|GYS1_ENST00000457974.1_5'UTR|GYS1_ENST00000540532.1_Missense_Mutation_p.A71T|GYS1_ENST00000541188.1_Missense_Mutation_p.A71T|GYS1_ENST00000263276.6_Intron	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	151					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		AAGAGGACAGCGTCGTTGGCC	0.607000													6	11					0	0	1	0	0
ALOX15	246	broad.mit.edu	37	17	4535496	4535496	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4535496C>T	ENST00000570836.1	-	13	1717	c.1621G>A	c.(1621-1623)Gcc>Acc	p.A541T	ALOX15_ENST00000293761.3_Missense_Mutation_p.A541T|ALOX15_ENST00000574640.1_Missense_Mutation_p.A502T|ALOX15_ENST00000545513.1_Missense_Mutation_p.A563T			P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	541	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	TGCACAGAGGCGTGTTGGCCG	0.592000													12	19					0	0	1	0	0
KCNJ14	3770	broad.mit.edu	37	19	48965165	48965165	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:48965165C>T	ENST00000391884.1	+	1	660	c.184C>T	c.(184-186)Cgt>Tgt	p.R62C	KCNJ14_ENST00000342291.2_Missense_Mutation_p.R62C			Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 14	62						voltage-gated potassium channel complex	inward rectifier potassium channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|skin(2)|urinary_tract(1)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		CTGCAACGTGCGTTTCGTAAA	0.687000													6	5					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27105808	27105808	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:27105808A>G	ENST00000324856.7	+	20	5790	c.5419A>G	c.(5419-5421)Agt>Ggt	p.S1807G	ARID1A_ENST00000374152.2_Missense_Mutation_p.S1424G|ARID1A_ENST00000540690.1_Missense_Mutation_p.S135G|ARID1A_ENST00000457599.2_Missense_Mutation_p.S1590G	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1807					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GAAGCTGATCAGTAAGTTTGA	0.448000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								3	23					0	0	1	0	0
PRR5-ARHGAP8	0	broad.mit.edu	37	22	45244820	45244820	+	Missense_Mutation	SNP	G	G	A	rs112956019		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:45244820G>A	ENST00000352766.7	+	15	1387	c.1387G>A	c.(1387-1389)Gtg>Atg	p.V463M	ARHGAP8_ENST00000356099.6_Missense_Mutation_p.V253M|ARHGAP8_ENST00000336963.4_Missense_Mutation_p.V253M|ARHGAP8_ENST00000389773.5_Missense_Mutation_p.V375M|ARHGAP8_ENST00000517296.3_Missense_Mutation_p.V463M|ARHGAP8_ENST00000389774.2_Missense_Mutation_p.V284M|PRR5-ARHGAP8_ENST00000361473.5_Missense_Mutation_p.V384M																breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(10)|prostate(1)|skin(8)	30						AGGGAAGCCCGTGAACTTTGA	0.612000													30	51					0	0	1	0	0
C1orf146	388649	broad.mit.edu	37	1	92707800	92707800	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:92707800G>A	ENST00000370375.3	+	3	246	c.98G>A	c.(97-99)cGa>cAa	p.R33Q	C1orf146_ENST00000370373.2_5'UTR	NM_001012425.1	NP_001012425.1	Q5VVC0	CA146_HUMAN	chromosome 1 open reading frame 146	33										breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8		all_lung(203;0.00528)|Lung NSC(277;0.0193)		all cancers(265;0.00846)|Epithelial(280;0.0952)		CTAGAAAATCGAAGCCACAAA	0.299000													34	41					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	92998436	92998436	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:92998436C>T	ENST00000523629.1	-	9	1649	c.1195G>A	c.(1195-1197)Gcc>Acc	p.A399T	RUNX1T1_ENST00000436581.2_Missense_Mutation_p.A410T|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.A399T|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.A362T|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.A372T|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.A362T|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.A362T|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.A372T	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	399					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			AAGTCCTCGGCGTCACTGTAC	0.517000													40	58					0	0	1	0	0
FAM132A	388581	broad.mit.edu	37	1	1179365	1179365	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1179365C>T	ENST00000330388.2	-	4	531	c.500G>A	c.(499-501)cGg>cAg	p.R167Q		NM_001014980.2	NP_001014980.1	Q5T7M4	F132A_HUMAN	family with sequence similarity 132, member A	167						extracellular region				haematopoietic_and_lymphoid_tissue(1)|lung(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.22e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACCAGCGTCCGCTTGTCCAC	0.701000													3	5					0	0	1	0	0
TMEM199	147007	broad.mit.edu	37	17	26687580	26687580	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26687580A>G	ENST00000292114.3	+	4	494	c.404A>G	c.(403-405)gAc>gGc	p.D135G	TMEM199_ENST00000395404.3_5'UTR|TMEM199_ENST00000509083.1_Missense_Mutation_p.D135G|CTB-96E2.3_ENST00000591482.1_RNA	NM_152464.1	NP_689677.1	Q8N511	TM199_HUMAN	transmembrane protein 199	135						integral to membrane				endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	6	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		ACTCTCAGCGACCTGGGAAAG	0.463000													12	13					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36675211	36675211	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:36675211G>A	ENST00000399881.3	+	10	1076	c.1039G>A	c.(1039-1041)Gct>Act	p.A347T		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	347	RCK N-terminal.					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity	p.A347T(2)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CAGTGTGACCGCTTTCCTGAG	0.468000													19	53					0	0	1	0	0
PRKD2	25865	broad.mit.edu	37	19	47195019	47195019	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47195019A>G	ENST00000433867.1	-	13	2152	c.1675T>C	c.(1675-1677)Tca>Cca	p.S559P	PRKD2_ENST00000291281.4_Missense_Mutation_p.S559P|PRKD2_ENST00000601806.1_Missense_Mutation_p.S402P|PRKD2_ENST00000600194.1_Missense_Mutation_p.S402P|PRKD2_ENST00000595515.1_Missense_Mutation_p.S559P	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	559	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		AACTGCCCTGAGCCCAGCACT	0.587000													22	35					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27877906	27877906	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:27877906C>T	ENST00000374011.2	-	6	1689	c.721G>A	c.(721-723)Gac>Aac	p.D241N	AHDC1_ENST00000247087.5_Missense_Mutation_p.D241N|AHDC1_ENST00000482400.2_5'UTR	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	241	Pro-rich.						DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		ATGTCGGCGTCAGCAAGTTCT	0.667000													11	27					0	0	1	0	0
IGHV1-46	0	broad.mit.edu	37	14	106967495	106967495	+	RNA	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:106967495T>G	ENST00000390622.2	-	0	293																											GGTGAAGAACTTTCCTCTCAG	0.488000													14	21					0	0	1	0	0
THOC2	57187	broad.mit.edu	37	X	122761551	122761551	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:122761551T>C	ENST00000245838.8	-	23	2781	c.2750A>G	c.(2749-2751)cAg>cGg	p.Q917R	THOC2_ENST00000491737.1_Missense_Mutation_p.Q802R|THOC2_ENST00000355725.4_Missense_Mutation_p.Q917R	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	917					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						TACCATTTCCTGATTGTCATC	0.343000													23	11					0	0	1	0	0
RBM15B	29890	broad.mit.edu	37	3	51431205	51431205	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:51431205C>T	ENST00000323686.4	+	1	2475	c.2375C>T	c.(2374-2376)gCg>gTg	p.A792V		NM_013286.4	NP_037418.3	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	792	Interaction with Epstein-Barr virus BMLF1.|SPOC.				interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|large_intestine(5)|lung(3)	12				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AACGGCTATGCGGTCCTCTTA	0.637000													13	21					0	0	1	0	0
KRTAP19-3	337970	broad.mit.edu	37	21	31864120	31864120	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:31864120G>A	ENST00000334063.4	-	1	155	c.156C>T	c.(154-156)ggC>ggT	p.G52G		NM_181609.3	NP_853640.1	Q7Z4W3	KR193_HUMAN	keratin associated protein 19-3	52						intermediate filament				large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	9						CATATCCATAGCCTCCAAAGC	0.542000													80	36					0	0	1	0	0
SLC35A4	113829	broad.mit.edu	37	5	139947311	139947311	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:139947311C>T	ENST00000514199.1	+	2	2243	c.557C>T	c.(556-558)cCg>cTg	p.P186L	APBB3_ENST00000507279.1_Intron|SLC35A4_ENST00000323146.3_Missense_Mutation_p.P186L			Q96G79	S35A4_HUMAN	solute carrier family 35, member A4	186	Leu-rich.					Golgi membrane|integral to membrane	sugar:hydrogen symporter activity	p.P186L(1)		endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATATCACTCCGCTAGGCCTG	0.617000													35	50					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100181979	100181979	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:100181979G>A	ENST00000317233.4	-	19	3324	c.3089C>T	c.(3088-3090)aCg>aTg	p.T1030M	AFF3_ENST00000409579.1_Missense_Mutation_p.T1055M|AFF3_ENST00000356421.2_Missense_Mutation_p.T1055M|AFF3_ENST00000409236.1_Missense_Mutation_p.T1030M	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	1030				T -> YL (in Ref. 1; AAA98763).	multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TGAATACATCGTATAAGGAGA	0.448000													44	61					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881626	26881626	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:26881626G>A	ENST00000231021.4	-	12	2161	c.1989C>T	c.(1987-1989)ggC>ggT	p.G663G		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	663					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CTTCCCCGCCGCCTTCATCGT	0.438000													56	68					0	0	1	0	0
EXD2	0	broad.mit.edu	37	14	69704572	69704572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:69704572C>T	ENST00000409014.1	+	10	1855	c.1198C>T	c.(1198-1200)Caa>Taa	p.Q400*	EXD2_ENST00000409675.1_Nonsense_Mutation_p.Q400*|EXD2_ENST00000409018.3_Nonsense_Mutation_p.Q525*|EXD2_ENST00000409242.1_Nonsense_Mutation_p.Q400*|EXD2_ENST00000312994.5_Nonsense_Mutation_p.Q525*|EXD2_ENST00000409949.1_Nonsense_Mutation_p.Q400*|EXD2_ENST00000492815.1_3'UTR|EXD2_ENST00000449989.1_Nonsense_Mutation_p.Q400*	NM_001193360.1	NP_001180289.1	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	400					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|urinary_tract(1)	14						GGAGCTGCTGCAAGCACTCAG	0.587000													8	5					0	0	1	0	0
AOC2	314	broad.mit.edu	37	17	40998087	40998087	+	Missense_Mutation	SNP	C	C	T	rs151168110		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40998087C>T	ENST00000253799.3	+	1	1471	c.1444C>T	c.(1444-1446)Cgg>Tgg	p.R482W	AOC2_ENST00000452774.2_Missense_Mutation_p.R482W	NM_009590.2	NP_033720.2	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 (retina-specific)	482					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity	p.R482W(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(14)|ovary(4)|skin(2)	30		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		ACTTGAAGGGCGGGTCCATGC	0.547000													5	88					0	0	1	0	0
ZNF366	0	broad.mit.edu	37	5	71752270	71752270	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:71752270G>A	ENST00000318442.5	-	3	1975	c.1485C>T	c.(1483-1485)caC>caT	p.H495H		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	495					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GGACGATCATGTGTGCCTTGA	0.547000													90	106					0	0	1	0	0
MDH1	4190	broad.mit.edu	37	2	63833095	63833095	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:63833095T>C	ENST00000233114.8	+	8	1247	c.812T>C	c.(811-813)gTt>gCt	p.V271A	MDH1_ENST00000544381.1_Missense_Mutation_p.V182A|MDH1_ENST00000539945.1_Missense_Mutation_p.V289A|MDH1_ENST00000409908.1_Missense_Mutation_p.V106A|MDH1_ENST00000409476.1_Missense_Mutation_p.V147A|MDH1_ENST00000394423.1_Missense_Mutation_p.V271A	NM_005917.3	NP_005908.1	P40925	MDHC_HUMAN	malate dehydrogenase 1, NAD (soluble)	271					gluconeogenesis|tricarboxylic acid cycle	centrosome|cytosol	L-malate dehydrogenase activity|malic enzyme activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(4)	13					NADH(DB00157)	TCCATGGGTGTTATCTCTGAT	0.378000													51	98					0	0	1	0	0
HHAT	55733	broad.mit.edu	37	1	210591653	210591653	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:210591653C>T	ENST00000367010.1	+	7	1067	c.840C>T	c.(838-840)gtC>gtT	p.V280V	HHAT_ENST00000537898.1_Silent_p.V215V|HHAT_ENST00000308852.6_Silent_p.V235V|HHAT_ENST00000545781.1_Silent_p.V217V|HHAT_ENST00000545154.1_Silent_p.V281V|HHAT_ENST00000541565.1_Silent_p.V143V|HHAT_ENST00000391905.3_Silent_p.V280V|HHAT_ENST00000413764.2_Silent_p.V280V|HHAT_ENST00000261458.3_Silent_p.V280V	NM_001170580.1	NP_001164051.1	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	280					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		TGGAGACTGTCTCTTGTTGGA	0.562000													4	36					0	0	1	0	0
PTPN9	5780	broad.mit.edu	37	15	75761284	75761284	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75761284C>A	ENST00000306726.2	-	13	2120	c.1608G>T	c.(1606-1608)gaG>gaT	p.E536D		NM_002833.2	NP_002824.1	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type 9	536	Tyrosine-protein phosphatase.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGCCAAGCTCCTCCAGCTGTG	0.527000													5	19					0.014758	0.0148771	1	1	0
CLTB	1212	broad.mit.edu	37	5	175824951	175824951	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:175824951C>A	ENST00000310418.4	-	3	537	c.332G>T	c.(331-333)aGg>aTg	p.R111M	CLTB_ENST00000345807.2_Missense_Mutation_p.R111M	NM_007097.3	NP_009028.1	P09497	CLCB_HUMAN	clathrin, light chain B	111	Involved in binding clathrin heavy chain.				intracellular protein transport|vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle	protein binding|structural molecule activity			lung(1)	1	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.098)		CAGCCGTTTCCTCTGCTCCTC	0.657000													33	60					5.71845e-15	6.25391e-15	1	1	0
TTC21A	199223	broad.mit.edu	37	3	39159586	39159586	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:39159586T>C	ENST00000301819.6	+	7	920	c.743T>C	c.(742-744)aTt>aCt	p.I248T	TTC21A_ENST00000431162.2_Missense_Mutation_p.I248T|TTC21A_ENST00000440121.1_Missense_Mutation_p.I207T	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	248							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GAGAGCAATATTGATGCCTGC	0.428000													44	63					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96106267	96106267	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:96106267G>A	ENST00000453304.1	-	13	2565	c.2217C>T	c.(2215-2217)caC>caT	p.H739H		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	739					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GGCGCAGGTTGTGGGTGCTGC	0.463000													46	65					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96701627	96701627	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:96701627T>C	ENST00000260682.6	+	2	193	c.181T>C	c.(181-183)Tat>Cat	p.Y61H	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	61					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	CTCAAAGGTCTATGGCCCTGT	0.413000													44	84					0	0	1	0	0
PLCXD1	55344	broad.mit.edu	37	X	207434	207434	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:207434G>A	ENST00000381657.2	+	4	898	c.384G>A	c.(382-384)gcG>gcA	p.A128A	PLCXD1_ENST00000381663.3_Silent_p.A128A|PLCXD1_ENST00000399012.1_Silent_p.A128A|PLCXD1_ENST00000484611.2_3'UTR	NM_018390.3	NP_060860.1	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 1	128	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process		phospholipase C activity			endometrium(3)|large_intestine(1)|lung(7)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACACAACGGCGCTGGTGGAGG	0.667000													9	20					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037218	75037218	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:75037218C>T	ENST00000326665.5	-	14	4394	c.4176G>A	c.(4174-4176)gaG>gaA	p.E1392E	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1392	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTCCTACTAACTCATCCTGTT	0.498000													26	47					0	0	1	0	0
TSC22D1	8848	broad.mit.edu	37	13	45148315	45148315	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:45148315C>A	ENST00000458659.2	-	1	2386	c.1896G>T	c.(1894-1896)caG>caT	p.Q632H	TSC22D1_ENST00000501704.2_Intron	NM_183422.3	NP_904358.2	Q15714	T22D1_HUMAN	TSC22 domain family, member 1	632	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		CCATTGGTTGCTGTTGTCCAT	0.507000													27	45					1.75199e-13	1.90424e-13	1	1	0
OR2L13	284521	broad.mit.edu	37	1	248263256	248263256	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:248263256C>T	ENST00000366478.2	+	3	916	c.579C>T	c.(577-579)gtC>gtT	p.V193V	OR2L13_ENST00000358120.2_Silent_p.V193V	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ATACTTGGGTCTATGAATATA	0.438000													55	66					0	0	1	0	0
ZNF18	7566	broad.mit.edu	37	17	11896029	11896029	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:11896029C>T	ENST00000322748.3	-	4	722	c.118G>A	c.(118-120)Gca>Aca	p.A40T	ZNF18_ENST00000580613.1_5'UTR|ZNF18_ENST00000580306.1_Missense_Mutation_p.A40T|ZNF18_ENST00000454073.3_Missense_Mutation_p.A40T	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	40					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		AGCTGGCGTGCGGTCTCAGGG	0.582000													26	37					0	0	1	0	0
PTGS2	5743	broad.mit.edu	37	1	186646006	186646006	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:186646006G>A	ENST00000367468.5	-	6	818	c.682C>T	c.(682-684)Cgt>Tgt	p.R228C	PTGS2_ENST00000490885.2_5'UTR	NM_000963.2	NP_000954.1	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	228			R -> H (in dbSNP:rs3218622).		cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	CGCAGTTTACGCTGTCTAGCC	0.308000													52	96					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207527852	207527852	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:207527852G>A	ENST00000452335.2	-	11	1524	c.1408C>T	c.(1408-1410)Caa>Taa	p.Q470*		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	470						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		GGCATCTTTTGTGTTTGGCTT	0.493000													14	17					0	0	1	0	0
SMURF1	57154	broad.mit.edu	37	7	98633252	98633252	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:98633252C>T	ENST00000361125.1	-	17	2294	c.1975G>A	c.(1975-1977)Gtg>Atg	p.V659M	AC004893.11_ENST00000360902.1_RNA|SMURF1_ENST00000361368.2_Missense_Mutation_p.V633M|AC004893.11_ENST00000468960.2_RNA	NM_020429.2	NP_065162.1	Q9HCE7	SMUF1_HUMAN	SMAD specific E3 ubiquitin protein ligase 1	659	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|urinary_tract(1)	25	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			AACCACCGCACGATGTTGCTG	0.577000													15	20					0	0	1	0	0
ZBTB9	221504	broad.mit.edu	37	6	33423633	33423633	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33423633A>G	ENST00000395064.2	+	2	1024	c.756A>G	c.(754-756)ccA>ccG	p.P252P		NM_152735.3	NP_689948.1	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	252	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(1)|upper_aerodigestive_tract(2)	11						GACCCCACCCACTGCCCATGA	0.562000													13	25					0	0	1	0	0
VPS26A	9559	broad.mit.edu	37	10	70917884	70917884	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:70917884C>A	ENST00000373382.1	+	6	1121	c.468C>A	c.(466-468)acC>acA	p.T156T	VPS26A_ENST00000395098.1_Silent_p.T156T|VPS26A_ENST00000263559.6_Silent_p.T156T|VPS26A_ENST00000546041.1_Silent_p.T139T|VPS26A_ENST00000490696.1_Intron|VPS26A_ENST00000489794.1_Silent_p.T131T|VPS26A_ENST00000541711.1_Silent_p.T45T			O75436	VP26A_HUMAN	vacuolar protein sorting 26 homolog A (S. pombe)	156					retrograde transport, endosome to Golgi|vacuolar transport	cytosol|endosome membrane|retromer complex|vesicle	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)	8						AGCTTGCCACCTATCCTGATG	0.323000													14	25					6.94344e-10	7.39541e-10	1	1	0
TMEM132B	114795	broad.mit.edu	37	12	126138923	126138923	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:126138923C>T	ENST00000299308.3	+	9	2912	c.2904C>T	c.(2902-2904)tgC>tgT	p.C968C	TMEM132B_ENST00000535886.1_Silent_p.C480C	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	968						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CAGAGGAGTGCACAACCATGA	0.512000													13	21					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108139244	108139244	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:108139244G>A	ENST00000278616.4	+	18	3131	c.2746G>A	c.(2746-2748)Gtg>Atg	p.V916M	ATM_ENST00000452508.2_Missense_Mutation_p.V916M	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	916					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GACCAATACTGTGTCCTTTAG	0.393000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			4	117					0	0	1	0	0
YBX3	8531	broad.mit.edu	37	12	10865863	10865863	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:10865863G>A	ENST00000228251.4	-	5	720	c.520C>T	c.(520-522)Cgg>Tgg	p.R174W	YBX3_ENST00000279550.7_Missense_Mutation_p.R174W	NM_003651.4	NP_003642.3			Y box binding protein 3																		TAACGGCGCCGATCTGCAGCG	0.517000													4	81					0	0	1	0	0
GTDC2	0	broad.mit.edu	37	3	43121556	43121556	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:43121556G>T	ENST00000344697.2	-	2	1713	c.1368C>A	c.(1366-1368)tcC>tcA	p.S456S	GTDC2_ENST00000441964.1_Silent_p.S456S	NM_032806.4	NP_116195.2																					TTTGAATGAGGGACGGGATGT	0.617000													10	5					2.80697e-09	2.97546e-09	1	1	0
NOXO1	0	broad.mit.edu	37	16	2031296	2031296	+	Translation_Start_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2031296C>T	ENST00000354249.4	-	0	254				TBL3_ENST00000568546.1_3'UTR|NOXO1_ENST00000356120.4_De_novo_Start_OutOfFrame	NM_001267721.1|NM_144603.3|NM_172167.2|NM_172168.2	NP_001254650.1|NP_653204.1|NP_751907.1|NP_751908.1	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1						cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity			lung(2)	2						CCTGGCAACACCTCAAGCCTG	0.617000													4	2					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45400384	45400384	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:45400384G>T	ENST00000389039.6	-	13	1820	c.1435C>A	c.(1435-1437)Cta>Ata	p.L479I	DUOX2_ENST00000603300.1_Missense_Mutation_p.L479I			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	479	Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		AGCTGGGATAGGTCCTGGTTG	0.627000													11	27					3.86212e-05	3.97146e-05	1	1	0
BTBD2	55643	broad.mit.edu	37	19	1990006	1990006	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1990006C>T	ENST00000255608.4	-	5	1001	c.985G>A	c.(985-987)Gca>Aca	p.A329T	AC005306.3_ENST00000588480.1_RNA|AC005306.3_ENST00000587498.1_RNA	NM_017797.3	NP_060267.2	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	329						cytoplasmic mRNA processing body	protein binding			endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|stomach(1)	12		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGTTACCTGCAGCGAACTCC	0.637000													12	14					0	0	1	0	0
BHMT	635	broad.mit.edu	37	5	78417174	78417174	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:78417174G>A	ENST00000274353.5	+	5	718	c.611G>A	c.(610-612)cGc>cAc	p.R204H	DMGDH_ENST00000520388.1_5'UTR|BHMT_ENST00000524080.1_Intron	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	204	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	TGTGCAGTGCGCCTGGTGAAA	0.468000													19	29					0	0	1	0	0
ABAT	18	broad.mit.edu	37	16	8851662	8851662	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:8851662C>T	ENST00000396600.2	+	6	1303	c.366_splice	c.e6+1	p.A122_splice	ABAT_ENST00000567812.1_Splice_Site_p.A137_splice|ABAT_ENST00000268251.8_Splice_Site_p.A122_splice|ABAT_ENST00000425191.2_Splice_Site_p.A122_splice|ABAT_ENST00000569156.1_Splice_Site_p.A122_splice	NM_000663.4	NP_000654.2	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase	122					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	26					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	CCTCAAAATGCGGTAGGTCTT	0.473000													15	15					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53672318	53672318	+	Silent	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:53672318A>C	ENST00000379925.3	-	20	3014	c.2964T>G	c.(2962-2964)acT>acG	p.T988T	RPGRIP1L_ENST00000564374.1_Silent_p.T988T|RPGRIP1L_ENST00000563746.1_Intron|RPGRIP1L_ENST00000262135.4_Intron	NM_015272.2	NP_056087.2	Q68CZ1	FTM_HUMAN	RPGRIP1-like	988					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				GAGGAGGAGAAGTCTCCTTAT	0.318000													14	21					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46299297	46299297	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46299297G>A	ENST00000221538.3	-	6	2126	c.1984C>T	c.(1984-1986)Cca>Tca	p.P662S	RSPH6A_ENST00000597055.1_Silent_p.C660C|RSPH6A_ENST00000600188.1_Missense_Mutation_p.P398S	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	662	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						ATGGGGGCTGGCAGGGCCGGG	0.552000													47	69					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154174848	154174848	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:154174848C>T	ENST00000336314.4	+	8	1139	c.1115C>T	c.(1114-1116)gCc>gTc	p.A372V		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	449							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CGAGTGCAGGCCCTTACCACT	0.517000													15	19					0	0	1	0	0
AC004381.6	0	broad.mit.edu	37	16	20835781	20835781	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:20835781T>A	ENST00000261377.6	+	7	846	c.637T>A	c.(637-639)Ttt>Att	p.F213I	AC004381.6_ENST00000564274.1_Missense_Mutation_p.F213I|AC004381.6_ENST00000348433.6_Missense_Mutation_p.F213I|ERI2_ENST00000564349.1_Intron|AC004381.6_ENST00000567297.1_Intron	NM_001199053.1|NM_030941.2	NP_001185982.1|NP_112203.2																					TTGTGAAAACTTTTTACTTAC	0.338000													20	31					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16339101	16339101	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:16339101C>T	ENST00000400202.1	-	3	2125	c.1413G>A	c.(1411-1413)tgG>tgA	p.W471*	NRIP1_ENST00000400199.1_Nonsense_Mutation_p.W471*|NRIP1_ENST00000318948.4_Nonsense_Mutation_p.W471*			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	471	Repression domain 2.|Required for targeting to small nuclear foci.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		CTTTTGGATCCCAAGTGTTTA	0.393000													18	36					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138400111	138400111	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:138400111C>T	ENST00000409968.1	+	21	4031	c.3853C>T	c.(3853-3855)Cca>Tca	p.P1285S	THSD7B_ENST00000272643.3_Missense_Mutation_p.P1288S|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.P1257S					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AGAAGGACGGCCATGCCCCAC	0.512000													20	27					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101926360	101926360	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:101926360C>T	ENST00000437600.4	+	23	2361	c.2009C>T	c.(2008-2010)gCg>gTg	p.A670V	CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000547394.2_Missense_Mutation_p.A656V|CUX1_ENST00000393824.3_Missense_Mutation_p.A633V|CUX1_ENST00000292538.4_Missense_Mutation_p.A672V|CUX1_ENST00000425244.2_Missense_Mutation_p.A626V	NM_181500.2	NP_852477.1	P39880	CUX1_HUMAN	cut-like homeobox 1	0					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						AACGGGGCTGCGGCTGGTGAC	0.622000													5	9					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19210286	19210286	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19210286C>T	ENST00000263200.10	-	15	2411	c.2339G>A	c.(2338-2340)cGt>cAt	p.R780H	CLTCL1_ENST00000353891.5_Missense_Mutation_p.R780H|CLTCL1_ENST00000427926.1_Missense_Mutation_p.R780H	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	780	Heavy chain arm.|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					AAAGCCAAAACGATCACACAC	0.502000			T	?	ALCL								4	7					0	0	1	0	0
ITPRIPL1	150771	broad.mit.edu	37	2	96993213	96993213	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:96993213G>A	ENST00000361124.4	+	1	1279	c.868G>A	c.(868-870)Gtg>Atg	p.V290M	ITPRIPL1_ENST00000536814.1_Missense_Mutation_p.V274M|ITPRIPL1_ENST00000542887.1_Missense_Mutation_p.V274M|ITPRIPL1_ENST00000439118.2_Missense_Mutation_p.V282M	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	282						integral to membrane		p.V290M(1)		breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCTAGGGGACGTGCTGTGCCT	0.612000													7	13					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179990054	179990054	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:179990054C>T	ENST00000367607.3	+	12	3563	c.3145C>T	c.(3145-3147)Caa>Taa	p.Q1049*		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1049						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						AGGTGGTACACAAAGCAAAGG	0.368000													5	8					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52056609	52056609	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:52056609C>T	ENST00000354534.5	+	2	186	c.8C>T	c.(7-9)gCg>gTg	p.A3V	SCN8A_ENST00000545061.1_Missense_Mutation_p.A3V|SCN8A_ENST00000550891.1_Missense_Mutation_p.A3V	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	3					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AAGATGGCAGCGCGGCTGCTT	0.517000													16	79					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1995182	1995182	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:1995182G>A	ENST00000382722.5	-	9	1379	c.1017C>T	c.(1015-1017)atC>atT	p.I339I	CACNA2D4_ENST00000585732.1_Intron|CACNA2D4_ENST00000587995.1_Silent_p.I339I|CACNA2D4_ENST00000588077.1_Silent_p.I275I|CACNA2D4_ENST00000585708.1_Silent_p.I275I|CACNA2D4_ENST00000586184.1_Silent_p.I339I	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	339	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AACAAGGCTCGATGTAATGGA	0.542000													7	15					0	0	1	0	0
NCLN	56926	broad.mit.edu	37	19	3192474	3192474	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3192474G>A	ENST00000246117.4	+	2	622	c.191G>A	c.(190-192)cGg>cAg	p.R64Q	NCLN_ENST00000590671.1_5'UTR	NM_020170.3	NP_064555.2	Q969V3	NCLN_HUMAN	nicalin	64					proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding			kidney(1)|lung(3)|skin(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGGCACACGGAATGCAGTG	0.697000													3	6					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879237	3879237	+	Missense_Mutation	SNP	C	C	T	rs113585667		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:3879237C>T	ENST00000315677.3	-	4	1427	c.832G>A	c.(832-834)Gcc>Acc	p.A278T	DLGAP1-AS3_ENST00000577649.1_RNA|DLGAP1_ENST00000584874.1_Missense_Mutation_p.A278T|DLGAP1_ENST00000581527.1_Missense_Mutation_p.A278T|DLGAP1_ENST00000515196.2_Missense_Mutation_p.A278T	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	278					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				GAGGACCAGGCGCTCTTCTTC	0.652000													17	37					0	0	1	0	0
PMEPA1	56937	broad.mit.edu	37	20	56227286	56227286	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:56227286C>T	ENST00000341744.3	-	4	1006	c.687G>A	c.(685-687)ccG>ccA	p.P229P	PMEPA1_ENST00000395816.3_Silent_p.P179P|PMEPA1_ENST00000265626.4_Silent_p.P179P|PMEPA1_ENST00000395814.1_Silent_p.P179P|PMEPA1_ENST00000347215.4_Silent_p.P194P	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	229					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						TGTAGGTGGGCGGCGGCCCCT	0.716000													10	10					0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25216578	25216578	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:25216578G>A	ENST00000276440.7	+	28	2993		c.e28+1			NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		AGACATCATCGTAAGTTGCCT	0.458000													12	64					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198950184	198950184	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:198950184G>A	ENST00000428675.1	+	2	2341	c.1943G>A	c.(1942-1944)aGg>aAg	p.R648K	PLCL1_ENST00000437704.2_Missense_Mutation_p.R550K	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	648	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	AGTGCCATGAGGATCGATTCC	0.408000													20	22					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167293928	167293928	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:167293928G>T	ENST00000308378.3	-	4	569	c.264C>A	c.(262-264)ctC>ctA	p.L88L	WDR49_ENST00000479765.1_Silent_p.L429L|WDR49_ENST00000453925.2_Silent_p.L141L	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	88										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						GAATATCCCAGAGTCTCAAAA	0.388000													9	16					2.17888e-05	2.24846e-05	1	1	0
ATP1B2	482	broad.mit.edu	37	17	7559184	7559184	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7559184G>A	ENST00000250111.4	+	7	1251	c.844G>A	c.(844-846)Gcc>Acc	p.A282T		NM_001678.3	NP_001669.3	P14415	AT1B2_HUMAN	ATPase, Na+/K+ transporting, beta 2 polypeptide	282					ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|pancreas(1)	10		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		CGGCCGCGTGGCCTTCAAACT	0.587000													7	15					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908404	103908404	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:103908404G>A	ENST00000302259.3	+	1	1097	c.854G>A	c.(853-855)cGg>cAg	p.R285Q	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	285					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GTGGACCGACGGTGGGCTGGG	0.512000													25	45					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47344500	47344500	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:47344500G>C	ENST00000398879.1	-	21	3118	c.2752C>G	c.(2752-2754)Ccc>Gcc	p.P918A	TNS3_ENST00000311160.9_Missense_Mutation_p.P918A|TNS3_ENST00000355730.3_Missense_Mutation_p.P678A			Q68CZ2	TENS3_HUMAN	tensin 3	918						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TGAAAGGAGGGCGTCGAGGAC	0.572000													7	14					0	0	1	0	0
ITGB7	3695	broad.mit.edu	37	12	53586194	53586194	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53586194G>A	ENST00000267082.5	-	14	2306	c.2075C>T	c.(2074-2076)aCc>aTc	p.T692I	ITGB7_ENST00000550743.2_Missense_Mutation_p.T544I|ITGB7_ENST00000422257.3_Missense_Mutation_p.T692I|ITGB7_ENST00000338737.4_Missense_Mutation_p.T544I	NM_000889.1	NP_000880.1	P26010	ITB7_HUMAN	integrin, beta 7	692					cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			NS(2)|breast(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GTTGTCCAGGGTCCGCTCTTT	0.577000													24	46					0	0	1	0	0
SERPINB5	5268	broad.mit.edu	37	18	61170612	61170612	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:61170612G>A	ENST00000382771.4	+	7	1077	c.785G>A	c.(784-786)aGc>aAc	p.S262N	SERPINB5_ENST00000464346.1_3'UTR	NM_002639.4	NP_002630.2	P36952	SPB5_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 5	262					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			kidney(3)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	12						ACTAATCCCAGCACCATGGCC	0.373000													13	28					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140391713	140391713	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140391713G>A	ENST00000406427.1	-	18	2275	c.1939C>T	c.(1939-1941)Cgc>Tgc	p.R647C	PNPLA7_ENST00000277531.4_Missense_Mutation_p.R622C|PNPLA7_ENST00000371457.1_Missense_Mutation_p.R228C	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	622					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		ATCACAGAGCGCAGCCGGCCG	0.682000													3	8					0	0	1	0	0
PPP2R2D	55844	broad.mit.edu	37	10	133769188	133769188	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:133769188C>T	ENST00000422256.2	+	8	883	c.397_splice	c.e8-1	p.A133_splice	PPP2R2D_ENST00000470416.1_3'UTR			Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B, delta	0					cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			endometrium(3)|large_intestine(3)|liver(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		TTTTGAACAGCGCCATCATGA	0.602000													14	17					0	0	1	0	0
ASCL4	121549	broad.mit.edu	37	12	108169471	108169471	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:108169471C>T	ENST00000342331.4	+	1	1310	c.479C>T	c.(478-480)tCg>tTg	p.S160L		NM_203436.2	NP_982260.2	Q6XD76	ASCL4_HUMAN	achaete-scute family bHLH transcription factor 4	159					regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|central_nervous_system(1)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	13						AAGGCCTCTTCGGCGCCTTCG	0.781000													4	8					0	0	1	0	0
HEG1	57493	broad.mit.edu	37	3	124731627	124731627	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:124731627G>A	ENST00000311127.4	-	6	2863	c.2796C>T	c.(2794-2796)ggC>ggT	p.G932G		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	932						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						CTGCTGTAACGCCAAGCTTTG	0.502000													6	26					0	0	1	0	0
CARKD	55739	broad.mit.edu	37	13	111279791	111279791	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:111279791G>A	ENST00000309957.2	+	5	406	c.392G>A	c.(391-393)aGc>aAc	p.S131N	CARKD_ENST00000424185.2_Missense_Mutation_p.S21N|CARKD_ENST00000397191.4_Missense_Mutation_p.S68N|CARKD_ENST00000470164.2_3'UTR|CARKD_ENST00000458711.2_Intron	NM_001242881.1|NM_018210.3	NP_001229810.1|NP_060680.2	Q8IW45	CARKD_HUMAN	carbohydrate kinase domain containing	131	YjeF C-terminal.									NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	15						TTTAGTGACAGCCCCAATGCT	0.443000													32	53					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241555812	241555812	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:241555812G>A	ENST00000270364.7	+	3	421	c.281G>A	c.(280-282)tGc>tAc	p.C94Y	GPR35_ENST00000319838.5_5'UTR|GPR35_ENST00000403859.1_5'UTR|GPR35_ENST00000438013.2_5'UTR			Q9HC96	CAN10_HUMAN	calpain 10	94	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		TAGGTCTCttgccctgtgcag	0.582000													92	148					0	0	1	0	0
ZKSCAN8	0	broad.mit.edu	37	6	28116402	28116402	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:28116402C>T	ENST00000330236.6	+	2	401	c.217C>T	c.(217-219)Cgg>Tgg	p.R73W	ZKSCAN8_ENST00000457389.2_Missense_Mutation_p.R73W	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		GATCCAACTACGGGCCCTTTG	0.552000													18	31					0	0	1	0	0
DCUN1D2	55208	broad.mit.edu	37	13	114112358	114112358	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:114112358G>A	ENST00000332592.3	-	5	401	c.367C>T	c.(367-369)Cgc>Tgc	p.R123C	DCUN1D2_ENST00000478244.1_Missense_Mutation_p.R256C			Q6PH85	DCNL2_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 2	256	DCUN1.									breast(1)|endometrium(1)|large_intestine(1)|lung(3)|stomach(1)	7	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.029)|GBM - Glioblastoma multiforme(44;0.234)			AAAAGGCTGCGTTTTCCACCT	0.443000											OREG0022535	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	242					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	233990468	233990468	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:233990468G>A	ENST00000359570.5	+	4	363	c.363G>A	c.(361-363)gtG>gtA	p.V121V	INPP5D_ENST00000538935.1_Silent_p.V121V|INPP5D_ENST00000474278.1_3'UTR			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	121					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		AAAGTGTCGTGTCTCCACCCG	0.602000													3	7					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192191	152192191	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:152192191C>G	ENST00000368801.2	-	3	1989	c.1914G>C	c.(1912-1914)caG>caC	p.Q638H	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	638					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGAGCCATGCTGACCGTGGC	0.567000													36	161					0	0	1	0	0
TBC1D5	9779	broad.mit.edu	37	3	17447938	17447938	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:17447938C>T	ENST00000253692.7	-	5	1912	c.248G>A	c.(247-249)aGc>aAc	p.S83N	TBC1D5_ENST00000429383.4_Missense_Mutation_p.S83N|TBC1D5_ENST00000414318.2_Intron|TBC1D5_ENST00000446818.2_Missense_Mutation_p.S83N|TBC1D5_ENST00000429924.2_Missense_Mutation_p.S35N	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	83	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						GAACCTGCTGCTTCTCAGCTG	0.383000													10	71					0	0	1	0	0
KCTD18	130535	broad.mit.edu	37	2	201354980	201354980	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:201354980C>T	ENST00000359878.3	-	7	1634	c.1124G>A	c.(1123-1125)cGg>cAg	p.R375Q	KCTD18_ENST00000409157.1_Missense_Mutation_p.R375Q	NM_152387.2	NP_689600.2	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain containing 18	375						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R375L(1)		endometrium(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						CTTTATCACCCGCTGGGGTGT	0.647000													21	25					0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20078990	20078990	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:20078990C>T	ENST00000351989.3	+	6	1768	c.1339C>T	c.(1339-1341)Cgt>Tgt	p.R447C	DGCR8_ENST00000383024.2_Missense_Mutation_p.R447C|DGCR8_ENST00000407755.1_Missense_Mutation_p.R447C	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	447	Necessary for heme-binding and pri-miRNA processing.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					CCTGGAGAAGCGTTTTGACTT	0.473000													51	78					0	0	1	0	0
DDX23	9416	broad.mit.edu	37	12	49237828	49237828	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49237828C>T	ENST00000308025.3	-	3	294	c.215G>A	c.(214-216)cGa>cAa	p.R72Q	DDX23_ENST00000553182.1_5'UTR	NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	72	Arg-rich.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						TTTGTGCCGTCGTTCTCTGGA	0.483000													56	79					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13413477	13413477	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:13413477C>T	ENST00000254508.5	-	13	1725	c.1643G>A	c.(1642-1644)cGt>cAt	p.R548H		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	548					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CTGGCCCACACGTGCCTCCAC	0.652000													3	2					0	0	1	0	0
ILVBL	10994	broad.mit.edu	37	19	15234345	15234345	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:15234345C>T	ENST00000263383.3	-	3	317	c.178G>A	c.(178-180)Gct>Act	p.A60T	ILVBL_ENST00000531635.1_5'UTR|ILVBL_ENST00000534378.1_5'UTR	NM_006844.3	NP_006835.2	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	60						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)	26						CTCAGCACAGCGGCCACGTTC	0.627000													8	28					0	0	1	0	0
ZNF763	284390	broad.mit.edu	37	19	12089672	12089672	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12089672C>A	ENST00000343949.5	+	4	1097	c.942C>A	c.(940-942)ccC>ccA	p.P314P	ZNF763_ENST00000545530.1_Silent_p.P189P|ZNF763_ENST00000358987.3_Silent_p.P311P|ZNF763_ENST00000590798.1_Silent_p.P331P|ZNF763_ENST00000538752.1_Silent_p.P331P	NM_001012753.1	NP_001012771.1			zinc finger protein 763											central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)	15						GGGAGAAGCCCTGTGAATGTA	0.403000													12	28					7.93312e-07	8.27737e-07	1	1	0
CCDC130	81576	broad.mit.edu	37	19	13869945	13869945	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13869945C>T	ENST00000586600.1	+	9	935	c.432C>T	c.(430-432)gaC>gaT	p.D144D	CCDC130_ENST00000587019.1_3'UTR|CCDC130_ENST00000221554.8_Silent_p.D144D			P13994	CC130_HUMAN	coiled-coil domain containing 130	144					response to virus		protein binding			endometrium(2)|kidney(1)|large_intestine(3)|ovary(1)|skin(2)|urinary_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			TGGAGACGGACGCCATGTTCC	0.662000													4	14					0	0	1	0	0
FRS3	10817	broad.mit.edu	37	6	41738655	41738655	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:41738655C>T	ENST00000373018.3	-	7	1432	c.1181G>A	c.(1180-1182)cGc>cAc	p.R394H	FRS3_ENST00000259748.2_Missense_Mutation_p.R394H	NM_006653.3	NP_006644.1	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	394					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGGGGAGCCGCGGCGGCGGGT	0.667000													7	32					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370965	240370965	+	Silent	SNP	G	G	A	rs6143701		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:240370965G>A	ENST00000319653.9	+	5	3083	c.2853G>A	c.(2851-2853)gcG>gcA	p.A951A		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	951	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TACCCGGAGCGGCAATACCCC	0.697000													15	23					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29867951	29867951	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:29867951G>A	ENST00000399218.4	-	4	664	c.609C>T	c.(607-609)caC>caT	p.H203H	GAREM_ENST00000269209.6_Silent_p.H203H|GAREM_ENST00000578619.1_5'UTR|RP11-344B2.2_ENST00000579580.1_RNA	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		CGTTGGTCCGGTGATTCATAC	0.478000													18	42					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12979924	12979924	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12979924C>T	ENST00000251472.4	+	22	2857	c.2818C>T	c.(2818-2820)Cga>Tga	p.R940*		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	940					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CATGTCTCCACGATCTCTGTC	0.567000													13	32					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55591228	55591228	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:55591228C>T	ENST00000373965.2	-	31	4464	c.4070G>A	c.(4069-4071)cGc>cAc	p.R1357H	PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.R1350H|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000409834.1_Missense_Mutation_p.R961H|PCDH15_ENST00000361849.3_Missense_Mutation_p.R1350H|PCDH15_ENST00000437009.1_Missense_Mutation_p.R1279H|PCDH15_ENST00000414778.1_Missense_Mutation_p.R1355H|PCDH15_ENST00000395433.1_Missense_Mutation_p.R1328H|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.R1350H|PCDH15_ENST00000395445.1_Missense_Mutation_p.R1357H|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395438.1_Missense_Mutation_p.R1350H|PCDH15_ENST00000395432.2_Missense_Mutation_p.R1313H	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1350					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.R1350H(2)|p.R1355H(2)		NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CTCCAGAATGCGTCCTCCTTC	0.418000										HNSCC(58;0.16)			23	51					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115827438	115827438	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:115827438G>A	ENST00000343348.6	-	7	1320	c.533C>T	c.(532-534)gCa>gTa	p.A178V	CTB-118N6.3_ENST00000514214.1_RNA|SEMA6A_ENST00000257414.8_Missense_Mutation_p.A178V|CTB-118N6.3_ENST00000508640.1_RNA|CTB-118N6.3_ENST00000510682.1_RNA|SEMA6A_ENST00000510263.1_Missense_Mutation_p.A178V|SEMA6A_ENST00000503962.1_5'UTR	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	178	Sema.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TCGCTTACCTGCAAACAGTGC	0.458000													37	57					0	0	1	0	0
BRD3	8019	broad.mit.edu	37	9	136907070	136907070	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136907070C>T	ENST00000303407.7	-	8	1404	c.1219G>A	c.(1219-1221)Gtg>Atg	p.V407M	BRD3_ENST00000357885.2_Missense_Mutation_p.V407M|BRD3_ENST00000371834.2_Missense_Mutation_p.V407M	NM_007371.3	NP_031397.1	Q15059	BRD3_HUMAN	bromodomain containing 3	407						nucleus	protein binding		BRD3/C15orf55(3)	kidney(1)|skin(1)|stomach(4)	6				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		ATCTCAAACACGTCCTGCGGC	0.662000			T	C15orf55	lethal midline carcinoma of young people								3	15					0	0	1	0	0
RPLP1	6176	broad.mit.edu	37	15	69747804	69747804	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:69747804C>T	ENST00000560274.1	+	2	175	c.110C>T	c.(109-111)cCg>cTg	p.P37L	RPLP1_ENST00000260379.6_Silent_p.S101S|RPLP1_ENST00000357790.5_Silent_p.S76S			P05386	RLA1_HUMAN	ribosomal protein, large, P1	0					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1						AAGAAGAATCCGAGGAGTCTG	0.353000													8	32					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502031	91502031	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:91502031A>G	ENST00000266718.4	-	2	1180	c.726T>C	c.(724-726)gcT>gcC	p.A242A	LUM_ENST00000548071.1_5'UTR	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	242					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						TTCCACTATCAGCCAGTTCGT	0.393000													10	71					0	0	1	0	0
PLK1	5347	broad.mit.edu	37	16	23700655	23700655	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:23700655G>A	ENST00000300093.4	+	8	1478	c.1367G>A	c.(1366-1368)cGt>cAt	p.R456H		NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	456	POLO box 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		TACATAGAGCGTGACGGCACT	0.552000													26	21					0	0	1	0	0
PPP2R2A	5520	broad.mit.edu	37	8	26212039	26212039	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:26212039G>A	ENST00000380737.3	+	4	565	c.236G>A	c.(235-237)aGc>aAc	p.S79N	PPP2R2A_ENST00000315985.7_Missense_Mutation_p.S89N	NM_002717.3	NP_002708.1			protein phosphatase 2, regulatory subunit B, alpha											kidney(1)|large_intestine(2)|ovary(1)	4		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		ACCTTCCAGAGCCATGAACCA	0.323000													4	73					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32915317	32915317	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:32915317G>T	ENST00000544455.1	+	11	7052	c.6825G>T	c.(6823-6825)gaG>gaT	p.E2275D	BRCA2_ENST00000380152.3_Missense_Mutation_p.E2275D	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2275			E -> G (in BC; unknown pathological significance).		cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GAAGAGGAGAGCCCCTTATCT	0.353000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			36	51					6.97489e-18	7.68957e-18	1	1	0
OR10P1	121130	broad.mit.edu	37	12	56031342	56031342	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56031342C>A	ENST00000309675.2	+	1	699	c.667C>A	c.(667-669)Ctg>Atg	p.L223M		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						CATCCGCATCCTGGGTGCCAT	0.552000													12	50					1.08611e-07	1.14056e-07	1	1	0
RHOBTB3	22836	broad.mit.edu	37	5	95091127	95091127	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:95091127C>T	ENST00000379982.3	+	6	1218	c.710C>T	c.(709-711)gCg>gTg	p.A237V	GLRX_ENST00000508780.1_Intron	NM_014899.3	NP_055714.3	O94955	RHBT3_HUMAN	Rho-related BTB domain containing 3	237					retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|skin(1)	16		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		AAGGCTGAAGCGTCACATTAT	0.353000													48	87					0	0	1	0	0
ARHGEF1	0	broad.mit.edu	37	19	42409371	42409371	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42409371C>T	ENST00000599846.1	+	25	2587	c.2462C>T	c.(2461-2463)cCt>cTt	p.P821L	ARHGEF1_ENST00000337665.4_Missense_Mutation_p.P780L|ARHGEF1_ENST00000354532.3_Missense_Mutation_p.P765L|ARHGEF1_ENST00000347545.4_Missense_Mutation_p.P732L|ARHGEF1_ENST00000378152.4_Missense_Mutation_p.P747L			Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor (GEF) 1	765					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		CTGAAAGTCCCTGCCCCTGCC	0.672000													22	30					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61556409	61556409	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61556409C>T	ENST00000290866.4	+	3	483	c.459C>T	c.(457-459)acC>acT	p.T153T	ACE_ENST00000584529.1_3'UTR|ACE_ENST00000428043.1_Silent_p.T153T|ACE_ENST00000538928.1_Silent_p.T153T	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	153	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TCTACTCCACCGCCAAGGTCT	0.632000											OREG0024639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	12					0	0	1	0	0
ACSM3	6296	broad.mit.edu	37	16	20787371	20787371	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:20787371G>T	ENST00000289416.5	+	3	905	c.430_splice	c.e3+1	p.G144_splice	ACSM3_ENST00000450120.2_Splice_Site_p.G99_splice|ACSM3_ENST00000440284.2_Splice_Site_p.G144_splice	NM_005622.3	NP_005613.2	Q53FZ2	ACSM3_HUMAN	acyl-CoA synthetase medium-chain family member 3	144					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	21						TCTGCGAACAGGTTAGTAATG	0.438000													22	47					3.83957e-06	3.98508e-06	1	1	0
TOMM7	54543	broad.mit.edu	37	7	22862308	22862308	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:22862308C>T	ENST00000358435.4	-	1	162	c.91G>A	c.(91-93)Gtg>Atg	p.V31M	TOMM7_ENST00000372879.4_Missense_Mutation_p.V31M|TOMM7_ENST00000463284.1_5'UTR	NM_019059.2	NP_061932.1	Q9P0U1	TOM7_HUMAN	translocase of outer mitochondrial membrane 7 homolog (yeast)	31					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			skin(1)	1						AGGTAAATCACAAGAGGGATA	0.587000													49	53					0	0	1	0	0
TYW1	55253	broad.mit.edu	37	7	66479425	66479425	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:66479425G>A	ENST00000359626.5	+	5	611	c.447G>A	c.(445-447)gaG>gaA	p.E149E		NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	149	Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				AAAGTGCAGAGTGGTTCTGCA	0.428000													55	64					0	0	1	0	0
CYP26A1	0	broad.mit.edu	37	10	94834933	94834933	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:94834933G>A	ENST00000371531.1	+	4	904	c.526G>A	c.(526-528)Gcg>Acg	p.A176T	CYP26A1_ENST00000224356.4_Missense_Mutation_p.A245T|CYP26A1_ENST00000394139.1_Missense_Mutation_p.A176T	NM_057157.2	NP_476498.1	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A, polypeptide 1	245					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Colorectal(252;0.122)				CCTCATTCACGCGCGCATCGA	0.687000													17	12					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103126834	103126834	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:103126834G>T	ENST00000428762.1	-	61	9952	c.9793C>A	c.(9793-9795)Ctt>Att	p.L3265I	RELN_ENST00000343529.5_Missense_Mutation_p.L3265I|RELN_ENST00000424685.2_Missense_Mutation_p.L3265I|CTB-107G13.1_ENST00000422488.1_RNA	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3265					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.L3265F(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TAACTGGGAAGGTCGTGACTG	0.448000													16	34					1.02788e-11	1.10723e-11	1	1	0
FDXR	2232	broad.mit.edu	37	17	72859228	72859228	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72859228C>T	ENST00000442102.2	-	11	1530	c.1444G>A	c.(1444-1446)Gca>Aca	p.A482T	FDXR_ENST00000420580.2_Missense_Mutation_p.A399T|FDXR_ENST00000544854.1_Missense_Mutation_p.A387T|FDXR_ENST00000583917.1_Missense_Mutation_p.A411T|FDXR_ENST00000455107.2_3'UTR|FDXR_ENST00000413947.2_Missense_Mutation_p.A470T|FDXR_ENST00000582944.1_Missense_Mutation_p.A431T|FDXR_ENST00000581530.1_Missense_Mutation_p.A445T|FDXR_ENST00000293195.5_Missense_Mutation_p.A439T	NM_001258012.1	NP_001244941.1	P22570	ADRO_HUMAN	ferredoxin reductase	439					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					TGGATGGCTGCGTAGCCAGGC	0.647000													10	9					0	0	1	0	0
CDYL	9425	broad.mit.edu	37	6	4937830	4937830	+	Missense_Mutation	SNP	C	C	T	rs148330526		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:4937830C>T	ENST00000328908.5	+	6	1273	c.1142C>T	c.(1141-1143)aCg>aTg	p.T381M	CDYL_ENST00000343762.5_Missense_Mutation_p.T195M|CDYL_ENST00000472453.1_3'UTR|CDYL_ENST00000449732.2_Missense_Mutation_p.T195M|CDYL_ENST00000397588.3_Missense_Mutation_p.T327M			Q9Y232	CDYL1_HUMAN	chromodomain protein, Y-like	381					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity			breast(2)|kidney(2)|large_intestine(9)|lung(13)|skin(1)|stomach(2)|urinary_tract(1)	30	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		GCTCTGAGCACGGCCGCTGCC	0.428000													7	11					0	0	1	0	0
CLDN16	10686	broad.mit.edu	37	3	190126206	190126206	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:190126206T>C	ENST00000264734.2	+	4	944	c.696T>C	c.(694-696)ttT>ttC	p.F232F	CLDN16_ENST00000456423.1_Intron	NM_006580.3	NP_006571.1	Q9Y5I7	CLD16_HUMAN	claudin 16	232			F -> C (in HOMG3).		calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|skin(1)	19	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		AATATAAATTTGGTTGGTCCT	0.418000													52	94					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12416057	12416057	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12416057C>T	ENST00000358136.3	+	48	9911	c.9781C>T	c.(9781-9783)Cag>Tag	p.Q3261*	VPS13D_ENST00000356315.4_Nonsense_Mutation_p.Q3236*	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3260					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CAACCGTCGGCAGCTGAACCT	0.453000													33	65					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984291	41984291	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:41984291C>T	ENST00000333141.5	+	1	579	c.482C>T	c.(481-483)gCg>gTg	p.A161V		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	161										breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						CTGCTCCCAGCGTCGCGGTTC	0.572000													26	46					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883382	228883382	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:228883382G>T	ENST00000392056.3	-	7	2234	c.2188C>A	c.(2188-2190)Ctt>Att	p.L730I	SPHKAP_ENST00000344657.5_Missense_Mutation_p.L730I	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	730						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CATTCACCAAGCCGTACAATA	0.453000													48	60					2.64894e-19	2.93014e-19	1	1	0
TRAP1	10131	broad.mit.edu	37	16	3736032	3736032	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3736032G>A	ENST00000246957.5	-	4	524	c.436C>T	c.(436-438)Cag>Tag	p.Q146*	TRAP1_ENST00000538171.1_Nonsense_Mutation_p.Q93*	NM_016292.2	NP_057376.2	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1	146					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(90;0.0261)				GCATTGGTCTGCAAGTGAATC	0.567000													20	30					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53998136	53998136	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:53998136C>T	ENST00000396328.1	-	10	1329	c.1090G>A	c.(1090-1092)Ggt>Agt	p.G364S	WDR72_ENST00000557913.1_Missense_Mutation_p.G361S|WDR72_ENST00000360509.5_Missense_Mutation_p.G364S|WDR72_ENST00000559418.1_Missense_Mutation_p.G374S	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	364										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		CTAGGAGAACCATCAAACTTG	0.383000													21	30					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73677127	73677127	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:73677127C>T	ENST00000264448.6	+	8	3581	c.3470C>T	c.(3469-3471)gCc>gTc	p.A1157V	ALMS1_ENST00000409009.1_Missense_Mutation_p.A1115V|ALMS1_ENST00000377715.1_Missense_Mutation_p.A1157V	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1157	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CACCAGCAGGCCTTGCCAGGT	0.478000													70	134					0	0	1	0	0
SPG21	51324	broad.mit.edu	37	15	65261632	65261632	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:65261632T>C	ENST00000559199.1	-	5	1167	c.167A>G	c.(166-168)gAa>gGa	p.E56G	SPG21_ENST00000204566.2_Missense_Mutation_p.E210G|SPG21_ENST00000433215.2_Missense_Mutation_p.E210G|SPG21_ENST00000416889.2_Missense_Mutation_p.E183G			Q9NZD8	SPG21_HUMAN	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	210					cell death	cytosol|endosome membrane|trans-Golgi network transport vesicle	CD4 receptor binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|urinary_tract(1)	10						TTTATGAGGTTCCACATAAGA	0.343000													17	61					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117642475	117642475	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:117642475C>T	ENST00000368508.3	-	35	5922	c.5724G>A	c.(5722-5724)gaG>gaA	p.E1908E	GOPC_ENST00000467125.1_5'UTR|ROS1_ENST00000368507.3_Silent_p.E1902E	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1908					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GACCTCGCAGCTCAGCCAACT	0.463000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								58	86					0	0	1	0	0
PIK3CD	5293	broad.mit.edu	37	1	9775719	9775719	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:9775719C>T	ENST00000536656.1	+	4	470	c.262C>T	c.(262-264)Cgt>Tgt	p.R88C	PIK3CD_ENST00000361110.2_Missense_Mutation_p.R88C|PIK3CD_ENST00000377346.4_Missense_Mutation_p.R88C			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	88					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		CGAGCAACGGCGTCTGTGTGA	0.617000													11	29					0	0	1	0	0
AASS	10157	broad.mit.edu	37	7	121773658	121773658	+	Silent	SNP	C	C	T	rs150573609	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:121773658C>T	ENST00000393376.1	-	1	218	c.123G>A	c.(121-123)ccG>ccA	p.P41P	AASS_ENST00000417368.2_Silent_p.P41P|AASS_ENST00000473553.1_Intron			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	41	Lysine-ketoglutarate reductase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	TGGGAGCTAGCGGGGCCCTTC	0.567000													15	17					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367424	234367424	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:234367424C>T	ENST00000366618.3	+	3	690	c.545C>T	c.(544-546)cCg>cTg	p.P182L	SLC35F3_ENST00000366617.3_Missense_Mutation_p.P113L	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	113					transport	integral to membrane		p.P182Q(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TTATTCTTCCCGTTGTACTAC	0.592000													10	216					0	0	1	0	0
GDF1	2657	broad.mit.edu	37	19	18980810	18980810	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18980810G>A	ENST00000247005.6	-	7	1652	c.307C>T	c.(307-309)Cgc>Tgc	p.R103C	CERS1_ENST00000427170.2_3'UTR					growth differentiation factor 1																		GGGATGTGGCGCACGATGTTT	0.716000													4	6					0	0	1	0	0
KRT40	125115	broad.mit.edu	37	17	39135121	39135121	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39135121G>A	ENST00000377755.4	-	6	1165	c.1131C>T	c.(1129-1131)gaC>gaT	p.D377D	KRT40_ENST00000398486.2_Silent_p.D377D			Q6A162	K1C40_HUMAN	keratin 40	377	Coil 2.|Rod.					intermediate filament	structural molecule activity			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Breast(137;0.00043)				GGGCCTTCACGTCCAGGAGCA	0.587000													40	61					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55880483	55880483	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:55880483C>A	ENST00000521992.1	-	14	1840	c.1695G>T	c.(1693-1695)gtG>gtT	p.V565V	CES5A_ENST00000290567.9_Silent_p.V536V|CES5A_ENST00000520435.1_Silent_p.V506V|CES5A_ENST00000518005.1_Silent_p.V430V|CES5A_ENST00000541580.1_5'UTR|CES5A_ENST00000319165.9_Silent_p.V486V	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	536						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						TCCAAAAATCCACCCGCGGTT	0.532000													71	128					2.69673e-31	3.02383e-31	1	1	0
TBATA	219793	broad.mit.edu	37	10	72531147	72531147	+	Silent	SNP	C	C	T	rs145511092		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:72531147C>T	ENST00000299290.1	-	11	1430	c.1041G>A	c.(1039-1041)ccG>ccA	p.P347P	TBATA_ENST00000394982.2_5'UTR	NM_152710.2	NP_689923.2			thymus, brain and testes associated																		TCTCTGCCCTCGGCTTCGATG	0.552000													47	66					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192701140	192701140	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:192701140C>T	ENST00000304141.4	-	2	1116	c.787G>A	c.(787-789)Gta>Ata	p.V263I		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	263						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TCTACAGATACGATCTTTGTC	0.423000													5	231					0	0	1	0	0
ASPH	444	broad.mit.edu	37	8	62430187	62430187	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:62430187C>T	ENST00000541428.1	-	24	2099	c.1939G>A	c.(1939-1941)Gtg>Atg	p.V647M	ASPH_ENST00000379454.4_Missense_Mutation_p.V676M	NM_001164750.1	NP_001158222.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	676					muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	TGCGGCCACACGTGAGTCCCG	0.512000													21	42					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5208351	5208351	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5208351G>A	ENST00000372412.4	-	36	5775	c.5542C>T	c.(5542-5544)Cag>Tag	p.Q1848*	PTPRS_ENST00000588012.1_Nonsense_Mutation_p.Q1809*|PTPRS_ENST00000587303.1_Nonsense_Mutation_p.Q1847*|PTPRS_ENST00000592099.1_Nonsense_Mutation_p.Q1400*|PTPRS_ENST00000348075.2_Nonsense_Mutation_p.Q1809*|PTPRS_ENST00000262963.6_Nonsense_Mutation_p.Q1827*|PTPRS_ENST00000357368.4_Nonsense_Mutation_p.Q1847*|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000353284.2_Nonsense_Mutation_p.Q1400*			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1847	Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGCACACCCTGTTCCGGCCAG	0.582000													7	31					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47043455	47043455	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47043455G>A	ENST00000450053.3	+	31	5007	c.4828G>A	c.(4828-4830)Gca>Aca	p.A1610T	NBEAL2_ENST00000292309.5_Missense_Mutation_p.A1426T|NBEAL2_ENST00000383740.2_5'UTR	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1610							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GCTACAGACTGCAGTGCCAGC	0.622000													7	11					0	0	1	0	0
MYO6	4646	broad.mit.edu	37	6	76600989	76600989	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:76600989G>A	ENST00000369981.3	+	27	3191	c.2912G>A	c.(2911-2913)aGa>aAa	p.R971K	MYO6_ENST00000369975.1_Missense_Mutation_p.R971K|MYO6_ENST00000369985.4_Missense_Mutation_p.R971K|MYO6_ENST00000369977.3_Missense_Mutation_p.R971K			Q9UM54	MYO6_HUMAN	myosin VI	971	Glu-rich.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GAAGAAGAGAGAAAGAAAAGG	0.343000													3	26					0	0	1	0	0
PDPR	55066	broad.mit.edu	37	16	70190674	70190674	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:70190674C>T	ENST00000288050.4	+	19	3489	c.2532C>T	c.(2530-2532)atC>atT	p.I844I	PDPR_ENST00000568530.1_Silent_p.I844I|PDPR_ENST00000562100.1_3'UTR|RP11-296I10.3_ENST00000566989.1_RNA|PDPR_ENST00000398122.3_Silent_p.I744I|PDPR_ENST00000542659.1_Silent_p.I189I|PDPR_ENST00000567046.1_Silent_p.I202I	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	844					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		AGATTGACATCGCGGGATACC	0.542000													11	52					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113684058	113684058	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:113684058G>A	ENST00000295878.3	-	17	2901	c.2755C>T	c.(2755-2757)Cta>Tta	p.L919L		NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	919										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						TGCTGATATAGCTCGTGGTAC	0.428000													18	58					0	0	1	0	0
TMEM117	84216	broad.mit.edu	37	12	44338119	44338119	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:44338119G>A	ENST00000536799.1	+	2	172	c.172G>A	c.(172-174)Gat>Aat	p.D58N	TMEM117_ENST00000266534.3_Silent_p.T128T|TMEM117_ENST00000551577.1_Silent_p.T128T			Q9H0C3	TM117_HUMAN	transmembrane protein 117	0						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TATACAACACGATTCTTCTAA	0.368000													24	52					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965976	88965976	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:88965976G>A	ENST00000333190.4	+	4	4289	c.3680G>A	c.(3679-3681)aGc>aAc	p.S1227N		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1227						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGTTCTCATAGCAGTCACCTC	0.473000										HNSCC(36;0.09)			23	47					0	0	1	0	0
OR4C46	119749	broad.mit.edu	37	11	51515403	51515403	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:51515403T>C	ENST00000328188.1	+	1	122	c.122T>C	c.(121-123)gTg>gCg	p.V41A		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V41A(1)		endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						GTGGGATATGTGCTCATTGTG	0.453000													9	119					0	0	1	0	0
SP4	6671	broad.mit.edu	37	7	21469341	21469341	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:21469341T>C	ENST00000222584.3	+	3	776	c.558T>C	c.(556-558)agT>agC	p.S186S		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	186	Poly-Ser.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						CAACTAGTAGTTCATCTCTAC	0.393000													35	38					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74018511	74018511	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74018511G>A	ENST00000301607.3	-	5	842	c.589C>T	c.(589-591)Cgg>Tgg	p.R197W	EVPL_ENST00000586740.1_Missense_Mutation_p.R197W	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	197	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						ACGAGGCTCCGCAGCTGCTGC	0.672000													5	7					0	0	1	0	0
WBP7	0	broad.mit.edu	37	19	36216181	36216181	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36216181C>T	ENST00000222270.7	+	11	3589	c.3589C>T	c.(3589-3591)Cca>Tca	p.P1197S	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Missense_Mutation_p.P1197S	NM_014727.1	NP_055542.1																					CACCTCTGTGCCAGGGGGCCC	0.607000													10	7					0	0	1	0	0
HDAC5	10014	broad.mit.edu	37	17	42170972	42170972	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42170972G>A	ENST00000225983.6	-	4	651	c.328C>T	c.(328-330)Cat>Tat	p.H110Y	HDAC5_ENST00000393622.2_Missense_Mutation_p.H109Y|HDAC5_ENST00000336057.5_Missense_Mutation_p.H109Y|HDAC5_ENST00000586802.1_Missense_Mutation_p.H109Y			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	109					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		TGGACCTCATGCTGCCTTGTC	0.652000													9	24					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945705	72945705	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:72945705C>T	ENST00000311131.2	+	3	968	c.501C>T	c.(499-501)ccC>ccT	p.P167P	P2RY2_ENST00000393597.2_Silent_p.P167P|P2RY2_ENST00000393596.2_Silent_p.P167P	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	167					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	GCCAGGCCCCCGTGCTCTACT	0.721000													17	21					0	0	1	0	0
RNF133	168433	broad.mit.edu	37	7	122338099	122338099	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:122338099T>C	ENST00000340112.2	-	1	1111	c.874A>G	c.(874-876)Aca>Gca	p.T292A	CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000412584.2_Intron|CADPS2_ENST00000449022.2_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	292						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						ATGGGGCATGTCCCATGGGGT	0.373000													34	45					0	0	1	0	0
CDX4	1046	broad.mit.edu	37	X	72667140	72667140	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:72667140T>C	ENST00000373514.2	+	1	51	c.51T>C	c.(49-51)acT>acC	p.T17T		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	17						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					ACCCGGGCACTCTCATGAGCC	0.612000													23	7					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40398445	40398445	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:40398445G>A	ENST00000221347.6	-	14	6529	c.6522C>T	c.(6520-6522)ggC>ggT	p.G2174G		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2174	VWFD 5.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCACGTCGGCGCCGCTCAGGT	0.682000													18	23					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18855617	18855617	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18855617C>T	ENST00000395647.2	+	1	140	c.99C>T	c.(97-99)gcC>gcT	p.A33A	SLC5A10_ENST00000395645.3_Silent_p.A33A|AC090286.4_ENST00000354432.3_RNA|SLC5A10_ENST00000417251.2_Silent_p.A33A|SLC5A10_ENST00000395642.1_5'UTR|SLC5A10_ENST00000317977.6_Intron|SLC5A10_ENST00000395643.2_Silent_p.A33A	NM_152351.3	NP_689564.3	A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	33					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						TGAATGTGGCCGTGGGCATAT	0.612000													4	0					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113683227	113683227	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:113683227C>T	ENST00000003302.4	-	16	1812		c.e16-1		USP28_ENST00000260188.5_Splice_Site|USP28_ENST00000545540.1_Splice_Site|USP28_ENST00000544967.1_Splice_Site	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28						cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		GATAAGGCACCTGTAAGTCAG	0.408000													15	41					0	0	1	0	0
DDX41	51428	broad.mit.edu	37	5	176939519	176939519	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176939519C>T	ENST00000507955.1	-	14	2050	c.1527G>A	c.(1525-1527)atG>atA	p.M509I		NM_016222.2	NP_057306.2	Q9UJV9	DDX41_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	509	Helicase C-terminal.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding					all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			TCTCCTCTGGCATGTCATAAT	0.582000													13	26					0	0	1	0	0
HR	55806	broad.mit.edu	37	8	21979159	21979159	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:21979159C>T	ENST00000381418.4	-	9	3650	c.2170G>A	c.(2170-2172)Ggc>Agc	p.G724S	HR_ENST00000312841.8_Missense_Mutation_p.G724S	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	724							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		TGGGTGTCGCCATTGCAGGAA	0.562000													32	46					0	0	1	0	0
C15orf38	348110	broad.mit.edu	37	15	90451581	90451581	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:90451581C>T	ENST00000357484.5	-	3	352	c.232G>A	c.(232-234)Gga>Aga	p.G78R	C15orf38_ENST00000460685.1_5'UTR|C15orf38-AP3S2_ENST00000398333.3_Missense_Mutation_p.G78R	NM_182616.2	NP_872422.1			chromosome 15 open reading frame 38											breast(3)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)	10	Melanoma(11;0.0171)|Lung NSC(78;0.0181)|all_lung(78;0.0384)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.223)			ATTTCATTTCCCTTGGCGTCG	0.587000													13	19					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513079	99513079	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:99513079C>T	ENST00000261037.3	+	5	714	c.334C>T	c.(334-336)Cca>Tca	p.P112S	COL8A1_ENST00000273342.4_Missense_Mutation_p.P112S	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	112	Nonhelical region (NC2).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						AGTAGAAATACCATTAGCCAG	0.512000													3	7					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36937458	36937458	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:36937458C>A	ENST00000262865.4	+	3	473	c.384C>A	c.(382-384)ttC>ttA	p.F128L	CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	128					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				AAAAGAGATTCTTGTGCGTTT	0.488000													14	45					1.3612e-06	1.41782e-06	1	1	0
ATE1	11101	broad.mit.edu	37	10	123600629	123600629	+	Silent	SNP	C	C	T	rs139300996		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:123600629C>T	ENST00000369043.3	-	9	1211	c.1125G>A	c.(1123-1125)tcG>tcA	p.S375S	ATE1_ENST00000369040.3_Silent_p.S279S|ATE1_ENST00000543447.1_Silent_p.S260S|ATE1_ENST00000540606.1_Silent_p.S368S|ATE1_ENST00000224652.6_Silent_p.S375S|ATE1_ENST00000535655.1_Silent_p.S76S	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	375					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				AAGACAAAAACGAATAATCAG	0.393000													10	14					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5890505	5890505	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:5890505G>A	ENST00000581347.1	-	3	2203	c.1558C>T	c.(1558-1560)Cgg>Tgg	p.R520W	RP11-945C19.4_ENST00000577694.1_RNA|TMEM200C_ENST00000383490.2_Missense_Mutation_p.R520W			A6NKL6	T200C_HUMAN	transmembrane protein 200C	520						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						CCGGAGTCCCGCCTGGTGGGG	0.736000													3	9					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123472782	123472782	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:123472782C>T	ENST00000280562.5	-	19	3183	c.2979_splice	c.e19+1	p.R993_splice	PITPNM2_ENST00000392428.1_Splice_Site_p.R720_splice|PITPNM2_ENST00000320201.4_Splice_Site_p.R999_splice|PITPNM2_ENST00000542749.1_Splice_Site_p.R999_splice			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	0					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GACCCTCACCCGCAGCTTCAC	0.622000													34	60					0	0	1	0	0
MFF	56947	broad.mit.edu	37	2	228195470	228195470	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:228195470C>T	ENST00000353339.3	+	4	608	c.167C>T	c.(166-168)gCa>gTa	p.A56V	MFF_ENST00000392059.1_Missense_Mutation_p.A56V|MFF_ENST00000354503.6_Missense_Mutation_p.A30V|MFF_ENST00000409616.1_Missense_Mutation_p.A30V|MFF_ENST00000476924.1_Intron|MFF_ENST00000349901.7_Missense_Mutation_p.A30V|MFF_ENST00000304593.9_Missense_Mutation_p.A30V|MFF_ENST00000409565.1_Missense_Mutation_p.A30V|MFF_ENST00000524634.1_Intron|MFF_ENST00000337110.7_Missense_Mutation_p.A30V	NM_001277061.1	NP_001263990.1	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	56						integral to membrane|mitochondrial outer membrane				breast(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(4)|stomach(2)	21						TTAAAAGTAGCACCGCCAAAC	0.438000													16	24					0	0	1	0	0
ARL5B	221079	broad.mit.edu	37	10	18962969	18962969	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:18962969T>C	ENST00000377275.3	+	5	629	c.396T>C	c.(394-396)tgT>tgC	p.C132C		NM_178815.3	NP_848930.1	Q96KC2	ARL5B_HUMAN	ADP-ribosylation factor-like 5B	132					small GTPase mediated signal transduction	intracellular	GTP binding			lung(1)|ovary(1)	2						TGAAAGGGTGTATGACAGCAG	0.398000													17	34					0	0	1	0	0
SAPCD1	401251	broad.mit.edu	37	6	31731263	31731263	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31731263C>T	ENST00000415669.2	+	2	245	c.186C>T	c.(184-186)ggC>ggT	p.G62G	MSH5-SAPCD1_ENST00000493662.2_3'UTR|SAPCD1_ENST00000425424.1_Silent_p.G62G|MSH5_ENST00000534153.4_3'UTR	NM_001039651.1	NP_001034740.1	Q5SSQ6	G7D_HUMAN	suppressor APC domain containing 1	62																	TACAGCATGGCCAGGCCTGGT	0.607000													5	55					0	0	1	0	0
SALL4	57167	broad.mit.edu	37	20	50401076	50401076	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:50401076C>T	ENST00000217086.4	-	4	3001	c.2890G>A	c.(2890-2892)Gtg>Atg	p.V964M	SALL4_ENST00000395997.3_Missense_Mutation_p.V527M|SALL4_ENST00000371539.3_Missense_Mutation_p.V187M	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	964					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ACAGGGTCCACATTCACTGAA	0.522000													40	52					0	0	1	0	0
PFAS	5198	broad.mit.edu	37	17	8167112	8167112	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8167112A>T	ENST00000314666.6	+	15	1782	c.1649A>T	c.(1648-1650)aAt>aTt	p.N550I	PFAS_ENST00000585319.1_3'UTR|PFAS_ENST00000545834.1_Missense_Mutation_p.N126I	NM_012393.2	NP_036525.1	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	550					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCAACCCTGAATGCCCTGGAA	0.587000													16	33					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153875374	153875374	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:153875374C>A	ENST00000511601.1	+	4	754	c.566C>A	c.(565-567)cCt>cAt	p.P189H	FHDC1_ENST00000260008.3_Missense_Mutation_p.P189H			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	189	FH2.				actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					TCAAGGTCTCCTCGGTCCATT	0.428000													24	20					5.35356e-11	5.74024e-11	1	1	0
PAK2	5062	broad.mit.edu	37	3	196547287	196547287	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:196547287G>A	ENST00000327134.3	+	13	1521	c.1199G>A	c.(1198-1200)cGc>cAc	p.R400H		NM_002577.4	NP_002568.2	Q13177	PAK2_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 2	400	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	12	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		CAGAGCAAACGCAGTACCATG	0.483000													10	46					0	0	1	0	0
CAMK2D	817	broad.mit.edu	37	4	114424106	114424106	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:114424106G>A	ENST00000454265.2	-	15	1903	c.1045C>T	c.(1045-1047)Cct>Tct	p.P349S	CAMK2D_ENST00000429180.1_Intron|CAMK2D_ENST00000511664.1_Missense_Mutation_p.P358S|CAMK2D_ENST00000508738.1_Intron|CAMK2D_ENST00000342666.5_Intron|CAMK2D_ENST00000379773.2_Intron|CAMK2D_ENST00000394526.2_Intron|CAMK2D_ENST00000394522.3_Missense_Mutation_p.P338S|CAMK2D_ENST00000505990.1_Missense_Mutation_p.P358S|CAMK2D_ENST00000515496.1_Intron|CAMK2D_ENST00000418639.2_Missense_Mutation_p.P338S|CAMK2D_ENST00000514328.1_Intron|CAMK2D_ENST00000394524.3_Intron|CAMK2D_ENST00000296402.5_Intron			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	327					interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		TTTCCATCAGGGTTGTGGATT	0.343000													13	24					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173910517	173910517	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:173910517T>C	ENST00000367696.2	-	19	3488	c.3135_splice	c.e19-1	p.E1046_splice	RC3H1_ENST00000367694.2_Splice_Site_p.E1037_splice|RC3H1_ENST00000258349.4_Splice_Site_p.E1046_splice			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	1046					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						ACACTGGTTTTCCTTTGAAAG	0.363000													8	57					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50955174	50955174	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:50955174C>T	ENST00000374103.4	-	9	1153	c.1068G>A	c.(1066-1068)tcG>tcA	p.S356S	OGDHL_ENST00000419399.1_Silent_p.S299S|OGDHL_ENST00000432695.1_Silent_p.S147S	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	356					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TGGCAACCAGCGACAGAGTGA	0.597000													18	40					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153220570	153220570	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153220570C>T	ENST00000310441.7	-	17	4246	c.3280G>A	c.(3280-3282)Gcc>Acc	p.A1094T	HCFC1_ENST00000369984.4_Missense_Mutation_p.A1094T|HCFC1_ENST00000354233.3_Missense_Mutation_p.A1025T	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	1094					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					Ttggaggtggcggtggtggcg	0.652000													19	3					0	0	1	0	0
PSMD12	5718	broad.mit.edu	37	17	65343566	65343566	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:65343566T>C	ENST00000356126.3	-	6	653	c.546A>G	c.(544-546)cgA>cgG	p.R182R	PSMD12_ENST00000357146.4_Silent_p.R162R	NM_002816.3	NP_002807.1	O00232	PSD12_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	182					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding			breast(1)|large_intestine(4)|lung(6)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)					TAAATTCCACTCGCTCTTTCT	0.363000													15	43					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47941165	47941165	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47941165G>A	ENST00000236877.6	-	7	2346	c.1951C>T	c.(1951-1953)Cca>Tca	p.P651S	SLC8A2_ENST00000542837.1_Missense_Mutation_p.P407S|SLC8A2_ENST00000539381.1_Missense_Mutation_p.P114S|SLC8A2_ENST00000601757.1_5'UTR	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	651					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCAAGAACTGGCTTGCCCATC	0.582000													39	78					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190603353	190603353	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190603353T>C	ENST00000520309.1	+	19	3733	c.3645T>C	c.(3643-3645)gtT>gtC	p.V1215V	ANKAR_ENST00000438402.2_3'UTR|ANKAR_ENST00000431575.2_Silent_p.V1144V|ANKAR_ENST00000281412.6_3'UTR|ANKAR_ENST00000313581.4_Silent_p.V1215V	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1215						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			CAAGAGGTGTTACTATTTTAG	0.323000													6	59					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122828495	122828495	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:122828495A>G	ENST00000264811.5	-	6	2219	c.1801T>C	c.(1801-1803)Tac>Cac	p.Y601H	TRPC3_ENST00000379645.3_Missense_Mutation_p.Y674H|TRPC3_ENST00000513531.1_Missense_Mutation_p.Y546H	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	589					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CCAAGGTAGTAAGAATAAAGT	0.343000													4	186					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206305231	206305231	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:206305231G>A	ENST00000406610.2	+	20	3086	c.2879G>A	c.(2878-2880)cGg>cAg	p.R960Q	PARD3B_ENST00000349953.3_Intron|PARD3B_ENST00000358768.2_Missense_Mutation_p.R898Q|PARD3B_ENST00000351153.1_Missense_Mutation_p.R891Q	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	960					cell cycle|cell division	endomembrane system|tight junction		p.R898L(1)|p.R899L(1)|p.R891L(1)		breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		AACCACTTTCGGGAACCATGC	0.473000													22	88					0	0	1	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60021739	60021739	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:60021739C>T	ENST00000586569.1	+	4	437	c.399C>T	c.(397-399)tgC>tgT	p.C133C	TNFRSF11A_ENST00000269485.7_Silent_p.C133C	NM_003839.2	NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	133					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				ACACCGAGTGCGCGCCGGGCC	0.677000													18	22					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39801166	39801166	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:39801166C>T	ENST00000564288.1	+	37	9683	c.8906C>T	c.(8905-8907)gCt>gTt	p.A2969V	MACF1_ENST00000476350.1_Intron|MACF1_ENST00000567887.1_Missense_Mutation_p.A3006V|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.A2974V|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000289893.4_Missense_Mutation_p.A1409V|MACF1_ENST00000545844.1_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2974					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCAATGAATGCTCGGGTGAAA	0.403000													27	31					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6114627	6114627	+	Translation_Start_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:6114627C>T	ENST00000409021.3	-	0	400				JAKMIP1_ENST00000410077.2_De_novo_Start_OutOfFrame|JAKMIP1_ENST00000282924.5_De_novo_Start_OutOfFrame|JAKMIP1_ENST00000457227.2_Intron|JAKMIP1_ENST00000409371.3_De_novo_Start_OutOfFrame|JAKMIP1_ENST00000409831.1_De_novo_Start_OutOfFrame	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1						protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CACCTGTTCACGCACGCCAGC	0.627000													7	9					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156816239	156816239	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:156816239C>T	ENST00000347377.6	+	29	3681	c.3250C>T	c.(3250-3252)Cgg>Tgg	p.R1084W	CYFIP2_ENST00000522463.1_Missense_Mutation_p.R888W|CYFIP2_ENST00000377576.3_Missense_Mutation_p.R1084W|CYFIP2_ENST00000541131.1_Missense_Mutation_p.R1009W|CYFIP2_ENST00000521420.1_Missense_Mutation_p.R1058W|CYFIP2_ENST00000435847.2_Missense_Mutation_p.R783W|CYFIP2_ENST00000442283.2_3'UTR|CYFIP2_ENST00000318218.6_Missense_Mutation_p.R1109W	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1109					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GACCAAGGAGCGGCTGTGCTG	0.602000													30	29					0	0	1	0	0
PCBP2	5094	broad.mit.edu	37	12	53865443	53865443	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53865443C>T	ENST00000603815.1	+	14	1263	c.913C>T	c.(913-915)Cgt>Tgt	p.R305C	PCBP2_ENST00000552819.1_Missense_Mutation_p.R262C|PCBP2_ENST00000546463.1_Missense_Mutation_p.R302C|PCBP2_ENST00000552296.2_Missense_Mutation_p.R301C|PCBP2_ENST00000548933.1_Missense_Mutation_p.R275C|PCBP2_ENST00000549863.1_Missense_Mutation_p.R261C|PCBP2_ENST00000455667.3_Missense_Mutation_p.R258C|PCBP2_ENST00000447282.1_Missense_Mutation_p.R275C|PCBP2_ENST00000439930.3_Missense_Mutation_p.R305C|PCBP2_ENST00000359462.5_Missense_Mutation_p.R306C|PCBP2_ENST00000437231.1_Missense_Mutation_p.R258C|PCBP2_ENST00000359282.5_Missense_Mutation_p.R271C	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	305	KH 3.				innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						CATAATCGGGCGTCAAGGCGC	0.498000													15	18					0	0	1	0	0
KCNK1	3775	broad.mit.edu	37	1	233802347	233802347	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:233802347G>A	ENST00000366621.3	+	2	530	c.362G>A	c.(361-363)gGc>gAc	p.G121D	KCNK1_ENST00000366620.1_Missense_Mutation_p.G5D|KCNK1_ENST00000472190.1_3'UTR	NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	121						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	GCAGGTTATGGCCACACCGTG	0.502000													18	13					0	0	1	0	0
FGD1	2245	broad.mit.edu	37	X	54475340	54475340	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:54475340T>C	ENST00000375135.3	-	16	3068	c.2335A>G	c.(2335-2337)Aac>Gac	p.N779D		NM_004463.2	NP_004454.2	P98174	FGD1_HUMAN	FYVE, RhoGEF and PH domain containing 1	779					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CACACACGGTTGGAGCGGTTG	0.627000													5	0					0	0	1	0	0
NEK6	10783	broad.mit.edu	37	9	127088703	127088703	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:127088703G>A	ENST00000373600.3	+	7	817	c.602G>A	c.(601-603)cGg>cAg	p.R201Q	NEK6_ENST00000394199.2_Missense_Mutation_p.R201Q|NEK6_ENST00000320246.5_Missense_Mutation_p.R167Q|NEK6_ENST00000546191.1_Missense_Mutation_p.R167Q|NEK6_ENST00000540326.1_Missense_Mutation_p.R185Q|NEK6_ENST00000373603.1_Missense_Mutation_p.R167Q|NEK6_ENST00000539416.1_Missense_Mutation_p.R192Q|NEK6_ENST00000545174.1_Missense_Mutation_p.R167Q	NM_001145001.2	NP_001138473.1	Q9HC98	NEK6_HUMAN	NIMA-related kinase 6	167	Protein kinase.				apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15						CATTCACGCCGGGTGATGCAC	0.622000													18	26					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3235284	3235284	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:3235284C>T	ENST00000217939.6	-	6	6592	c.6438G>A	c.(6436-6438)gcG>gcA	p.A2146A		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2146	Ig-like C2-type 6.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCGTGATGCGCGCGTTGGCTG	0.706000													5	2					0	0	1	0	0
SFSWAP	6433	broad.mit.edu	37	12	132250710	132250710	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:132250710C>T	ENST00000261674.4	+	13	2140	c.1999C>T	c.(1999-2001)Ctg>Ttg	p.L667L	SFSWAP_ENST00000541286.1_Silent_p.L667L	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	667					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						CCGGGAAAAGCTGGCCCAGGC	0.443000													5	121					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34099321	34099321	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:34099321G>A	ENST00000397527.1	+	35	7915	c.7195G>A	c.(7195-7197)Gcc>Acc	p.A2399T	CEP250_ENST00000342580.4_Missense_Mutation_p.A2343T	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	2399					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TCTTGCCGTGGCCCAGGCCCC	0.632000													5	29					0	0	1	0	0
PTHLH	5744	broad.mit.edu	37	12	28116656	28116656	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:28116656G>A	ENST00000535992.1	-	3	495	c.149C>T	c.(148-150)tCc>tTc	p.S50F	PTHLH_ENST00000395868.3_Missense_Mutation_p.S50F|PTHLH_ENST00000395872.1_Missense_Mutation_p.S50F|PTHLH_ENST00000201015.4_Missense_Mutation_p.S50F|PTHLH_ENST00000538310.1_Missense_Mutation_p.S50F|PTHLH_ENST00000539239.1_Missense_Mutation_p.S50F|PTHLH_ENST00000354417.3_Missense_Mutation_p.S50F|RP11-993B23.3_ENST00000538113.1_RNA|PTHLH_ENST00000545234.1_Missense_Mutation_p.S50F			P12272	PTHR_HUMAN	parathyroid hormone-like hormone	50					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	10	Lung SC(9;0.184)					ATCTTGGATGGACTTCCCCTT	0.443000													37	52					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52595924	52595924	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:52595924C>T	ENST00000395489.2	-	8	889	c.493G>A	c.(493-495)Gct>Act	p.A165T	A1CF_ENST00000374001.1_Missense_Mutation_p.A172T|A1CF_ENST00000373995.3_Missense_Mutation_p.A180T|A1CF_ENST00000373993.1_Missense_Mutation_p.A172T|A1CF_ENST00000395495.1_Missense_Mutation_p.A172T|A1CF_ENST00000373997.3_Missense_Mutation_p.A172T|A1CF_ENST00000282641.2_Missense_Mutation_p.A172T	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	172	RRM 2.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						TTATCTGCAGCGCTTGGGTAG	0.468000													78	124					0	0	1	0	0
CHAF1B	8208	broad.mit.edu	37	21	37781094	37781094	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:37781094A>G	ENST00000314103.4	+	9	944	c.793A>G	c.(793-795)Acc>Gcc	p.T265A		NM_005441.2	NP_005432.1	Q13112	CAF1B_HUMAN	chromatin assembly factor 1, subunit B (p60)	265					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(2)	20						TGTAATGAATACCACTTATGT	0.403000													7	22					0	0	1	0	0
THSD1	55901	broad.mit.edu	37	13	52971414	52971414	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:52971414C>T	ENST00000349258.4	-	3	1518	c.974G>A	c.(973-975)aGc>aAc	p.S325N	THSD1_ENST00000258613.4_Missense_Mutation_p.S325N|THSD1_ENST00000544466.1_Intron	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	325						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		AGAAAAATGGCTTCTGCTTGA	0.368000													10	43					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83829480	83829480	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:83829480C>T	ENST00000349129.2	+	9	1154	c.894C>T	c.(892-894)aaC>aaT	p.N298N	DOPEY1_ENST00000536812.1_3'UTR|DOPEY1_ENST00000237163.5_Intron|DOPEY1_ENST00000369739.3_Intron	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	298					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTGATAACAACGGTGCTATCA	0.348000													23	27					0	0	1	0	0
APOE	348	broad.mit.edu	37	19	45411122	45411122	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45411122G>A	ENST00000252486.4	+	3	260	c.149G>A	c.(148-150)cGc>cAc	p.R50H		NM_000041.2	NP_000032.1	P02649	APOE_HUMAN	apolipoprotein E	50					anti-apoptosis|Cdc42 protein signal transduction|cell death|cGMP-mediated signaling|cholesterol efflux|cholesterol homeostasis|chylomicron remnant clearance|cytoskeleton organization|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|induction of apoptosis|intracellular transport|negative regulation of blood vessel endothelial cell migration|negative regulation of cholesterol biosynthetic process|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of platelet activation|nitric oxide mediated signal transduction|phospholipid efflux|positive regulation of cGMP biosynthetic process|positive regulation of cholesterol efflux|positive regulation of cholesterol esterification|positive regulation of low-density lipoprotein particle receptor catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of nitric-oxide synthase activity|receptor-mediated endocytosis|regulation of axon extension|regulation of neuronal synaptic plasticity|response to reactive oxygen species|reverse cholesterol transport|synaptic transmission, cholinergic|triglyceride metabolic process|very-low-density lipoprotein particle clearance|very-low-density lipoprotein particle remodeling	chylomicron|dendrite|high-density lipoprotein particle|intermediate-density lipoprotein particle|low-density lipoprotein particle|neuronal cell body|very-low-density lipoprotein particle	antioxidant activity|beta-amyloid binding|heparin binding|low-density lipoprotein particle receptor binding|metal chelating activity|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding|protein heterodimerization activity|protein homodimerization activity|tau protein binding|very-low-density lipoprotein particle receptor binding			large_intestine(1)|lung(2)|prostate(1)	4	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)	Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	GCACTGGGTCGCTTTTGGGAT	0.652000													14	12					0	0	1	0	0
TRAV26-1	0	broad.mit.edu	37	14	22592198	22592198	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22592198G>A	ENST00000390455.3	+	0	492																											CCTGCCCCACGCTACGCTGAG	0.488000													8	10					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22161368	22161368	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:22161368G>A	ENST00000374695.3	-	77	10603	c.10524C>T	c.(10522-10524)ttC>ttT	p.F3508F		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3508	Ig-like C2-type 21.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCAGGCATTCGAACTCCACGG	0.637000													6	26					0	0	1	0	0
SGSM2	9905	broad.mit.edu	37	17	2282453	2282453	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:2282453G>A	ENST00000268989.3	+	23	3200	c.3023G>A	c.(3022-3024)cGt>cAt	p.R1008H	SGSM2_ENST00000574563.1_Missense_Mutation_p.R963H|RP1-59D14.5_ENST00000574290.1_RNA|SGSM2_ENST00000426855.2_Missense_Mutation_p.R963H	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	963						intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		GAGATCATCCGTGACAACAAC	0.577000													15	22					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317153	30317153	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:30317153C>T	ENST00000375377.1	-	3	2025	c.1924G>A	c.(1924-1926)Ggt>Agt	p.G642S		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	642										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						GTTCTCCCACCCATGCTTCCT	0.498000													16	33					0	0	1	0	0
MED7	9443	broad.mit.edu	37	5	156566357	156566357	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:156566357C>T	ENST00000286317.5	-	2	467	c.86G>A	c.(85-87)gGc>gAc	p.G29D	MED7_ENST00000420343.1_Missense_Mutation_p.G29D	NM_004270.4	NP_004261.1	O43513	MED7_HUMAN	mediator complex subunit 7	29					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	protein binding|transcription coactivator activity			kidney(1)|large_intestine(1)|lung(3)|urinary_tract(2)	7	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGGAGCTAAGCCTTCTTGAAT	0.433000													21	35					0	0	1	0	0
CDRT15	146822	broad.mit.edu	37	17	14140020	14140020	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:14140020C>T	ENST00000420162.2	-	1	146	c.131G>A	c.(130-132)cGc>cAc	p.R44H	CDRT15_ENST00000431716.2_Silent_p.A19A	NM_001007530.1	NP_001007531.1	Q96T59	CDRTF_HUMAN	CMT1A duplicated region transcript 15	44										endometrium(2)|large_intestine(1)|lung(2)|prostate(1)	6				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		TACCTGGATGCGCCTTATTAC	0.612000													6	13					0	0	1	0	0
ACTN4	81	broad.mit.edu	37	19	39218657	39218657	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39218657C>T	ENST00000252699.2	+	19	2485	c.2409C>T	c.(2407-2409)aaC>aaT	p.N803N	ACTN4_ENST00000497637.1_3'UTR|ACTN4_ENST00000390009.3_Silent_p.N584N|ACTN4_ENST00000424234.2_Silent_p.N413N	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	803					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			ACGTGGAGAACGACCGGCAGG	0.652000													8	12					0	0	1	0	0
RRP7B	0	broad.mit.edu	37	22	42970768	42970768	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:42970768G>A	ENST00000357802.2	-	0	840																											CGCTGGGCCCGCAGCAGCTCG	0.657000													23	23					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3413851	3413851	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:3413851C>T	ENST00000356575.4	-	27	3653	c.3427G>A	c.(3427-3429)Gtc>Atc	p.V1143I	MEGF6_ENST00000294599.4_Missense_Mutation_p.V952I	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	1143	EGF-like 21.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCCCCAGTGACGTGGTGGCAG	0.726000													4	14					0	0	1	0	0
FUCA1	2517	broad.mit.edu	37	1	24180991	24180991	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24180991G>T	ENST00000374479.3	-	5	835	c.828C>A	c.(826-828)taC>taA	p.Y276*		NM_000147.4	NP_000138.2	P04066	FUCO_HUMAN	fucosidase, alpha-L- 1, tissue	276					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		CACAGTTATAGTATCCTCCAT	0.458000													53	64					9.90819e-18	1.09129e-17	1	1	0
FOXB1	27023	broad.mit.edu	37	15	60297596	60297596	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:60297596C>T	ENST00000396057.4	+	2	913	c.434C>T	c.(433-435)aCg>aTg	p.T145M	FOXB1_ENST00000560857.1_Intron	NM_012182.2	NP_036314.2	Q99853	FOXB1_HUMAN	forkhead box B1	145					axon target recognition|cell migration in diencephalon|epithelial cell differentiation involved in mammary gland alveolus development|floor plate development|hypothalamus cell migration|inferior colliculus development|lactation|mammillothalamic axonal tract development|negative regulation of neuron apoptosis|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|telencephalon cell migration|visual learning	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)	6						GCCTCGGGCACGCACCTGCCA	0.706000													3	9					0	0	1	0	0
NEGR1	257194	broad.mit.edu	37	1	72400777	72400777	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:72400777G>A	ENST00000357731.4	-	2	633	c.394C>T	c.(394-396)Cat>Tat	p.H132Y	NEGR1_ENST00000306821.3_Missense_Mutation_p.H4Y|NEGR1_ENST00000434200.1_Missense_Mutation_p.H130Y|NEGR1_ENST00000467479.1_5'UTR	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	132	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		ACAGTTAGATGCACCTGCATT	0.393000													17	30					0	0	1	0	0
PMPCA	23203	broad.mit.edu	37	9	139311544	139311544	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139311544G>A	ENST00000371717.3	+	7	784	c.775G>A	c.(775-777)Gag>Aag	p.E259K	PMPCA_ENST00000462616.1_3'UTR|PMPCA_ENST00000399219.3_Missense_Mutation_p.E128K	NM_015160.1	NP_055975.1	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	259					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|urinary_tract(1)	14		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		CGTGGGCGTGGAGCACGAGCA	0.622000													4	25					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86199651	86199651	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:86199651C>T	ENST00000361228.3	-	2	505	c.137G>A	c.(136-138)cGc>cAc	p.R46H		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	46	Ras-associating.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AGAGGTGGTGCGTTTAGTCAG	0.458000													21	35					0	0	1	0	0
ENPP2	0	broad.mit.edu	37	8	120598437	120598437	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:120598437C>T	ENST00000427067.2	-	15	1524	c.1344G>A	c.(1342-1344)tgG>tgA	p.W448*	ENPP2_ENST00000522167.1_Nonsense_Mutation_p.W91*|ENPP2_ENST00000259486.6_Nonsense_Mutation_p.W504*|ENPP2_ENST00000522826.1_Nonsense_Mutation_p.W452*|ENPP2_ENST00000075322.6_Nonsense_Mutation_p.W452*			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	452					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTGCAACATGCCATCTGCGTT	0.413000													29	64					0	0	1	0	0
UAP1	6675	broad.mit.edu	37	1	162560256	162560256	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:162560256G>A	ENST00000271469.3	+	8	1615	c.1313G>A	c.(1312-1314)gGc>gAc	p.G438D	UAP1_ENST00000367925.1_Missense_Mutation_p.G438D|UAP1_ENST00000367926.4_Missense_Mutation_p.G438D|UAP1_ENST00000367924.1_Missense_Mutation_p.G438D			Q16222	UAP1_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1	438					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			breast(2)|cervix(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)|skin(2)|stomach(1)	22	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			AATGCAGGGGGCCATTTCATA	0.448000													25	29					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24427160	24427160	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:24427160G>A	ENST00000355123.4	-	39	5333	c.4890C>T	c.(4888-4890)gaC>gaT	p.D1630D	ITSN2_ENST00000361999.3_Silent_p.D1603D	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	1630	C2.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GACACAGCACGTCTTGGTAGA	0.498000													30	45					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26911191	26911191	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26911191G>A	ENST00000321765.5	-	13	2721	c.2389C>T	c.(2389-2391)Cgg>Tgg	p.R797W		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	797					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					TTCAGGTCCCGCACCTCTTTG	0.507000													40	60					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81960741	81960741	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:81960741C>T	ENST00000359376.3	+	23	2686	c.2472C>T	c.(2470-2472)gtC>gtT	p.V824V		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	824	SH3.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						CCAACTACGTCGAGGACATCT	0.527000													56	77					0	0	1	0	0
IRX4	50805	broad.mit.edu	37	5	1879621	1879621	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1879621C>T	ENST00000505790.1	-	5	1189	c.733G>A	c.(733-735)Gca>Aca	p.A245T	IRX4_ENST00000231357.2_Missense_Mutation_p.A245T|IRX4_ENST00000505938.1_5'UTR|IRX4_ENST00000513692.1_Missense_Mutation_p.A245T	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	245					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		AACCCACCTGCGTTCTTGGAG	0.667000													22	29					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166786784	166786784	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166786784C>T	ENST00000243344.7	-	9	1122	c.985G>A	c.(985-987)Gaa>Aaa	p.E329K		NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	329						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						TATCCAAGTTCTGTAGCAAAT	0.378000													28	37					0	0	1	0	0
CASP8	841	broad.mit.edu	37	2	202141679	202141679	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:202141679C>T	ENST00000358485.4	+	7	1163	c.967C>T	c.(967-969)Cac>Tac	p.H323Y	CASP8_ENST00000323492.7_Missense_Mutation_p.H249Y|CASP8_ENST00000392259.2_3'UTR|CASP8_ENST00000392266.3_3'UTR|CASP8_ENST00000264275.5_Missense_Mutation_p.H281Y|CASP8_ENST00000392258.3_3'UTR|CASP8_ENST00000264274.9_Intron|CASP8_ENST00000432109.2_Missense_Mutation_p.H264Y	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	264					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						GAATGGAACACACTTGGATGC	0.383000										HNSCC(4;0.00038)			12	20					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100064390	100064390	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:100064390A>G	ENST00000524871.1	+	15	2169	c.1879A>G	c.(1879-1881)Agg>Ggg	p.R627G	CNTN5_ENST00000279463.3_Missense_Mutation_p.R627G|CNTN5_ENST00000528682.1_Missense_Mutation_p.R627G|CNTN5_ENST00000418526.2_Missense_Mutation_p.R553G|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000527185.1_Missense_Mutation_p.R627G	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	627	Ig-like C2-type 6.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TGAAAGCATCAGGGCCGTAAG	0.363000													6	40					0	0	1	0	0
DNAJC30	84277	broad.mit.edu	37	7	73097608	73097608	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:73097608G>A	ENST00000395176.2	-	1	175	c.146C>T	c.(145-147)gCg>gTg	p.A49V	WBSCR22_ENST00000464615.1_3'UTR	NM_032317.2	NP_115693.2	Q96LL9	DJC30_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 30	49	J.				protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(2)|lung(1)	4						ATCATACAGCGCCGTGCGCGA	0.612000													5	88					0	0	1	0	0
WDR81	124997	broad.mit.edu	37	17	1635978	1635978	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1635978G>A	ENST00000409644.1	+	6	4342	c.4342G>A	c.(4342-4344)Gcg>Acg	p.A1448T	RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000446363.1_Missense_Mutation_p.A87T|WDR81_ENST00000545662.1_Missense_Mutation_p.A79T|WDR81_ENST00000419248.1_Missense_Mutation_p.A221T|WDR81_ENST00000437219.2_Missense_Mutation_p.A245T|WDR81_ENST00000309182.5_Missense_Mutation_p.A397T	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	221										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GCTGGACCCTGCGGGCCGTGG	0.692000													10	20					0	0	1	0	0
C2CD2L	9854	broad.mit.edu	37	11	118986911	118986911	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118986911G>A	ENST00000336702.3	+	14	2428	c.2069G>A	c.(2068-2070)cGc>cAc	p.R690H	C2CD2L_ENST00000528586.1_3'UTR	NM_014807.3	NP_055622.3	O14523	C2C2L_HUMAN	C2CD2-like	689						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)	13						CTTATCAAGCGCTTTTCCTTC	0.582000													12	15					0	0	1	0	0
HNF1B	6928	broad.mit.edu	37	17	36093663	36093663	+	Silent	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36093663G>C	ENST00000225893.4	-	3	1057	c.696C>G	c.(694-696)cgC>cgG	p.R232R	HNF1B_ENST00000561193.1_Silent_p.R206R|HNF1B_ENST00000560016.1_Silent_p.R232R|HNF1B_ENST00000427275.2_Silent_p.R206R	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	232					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			ACCGGTTGCGGCGCATCTTCT	0.567000													16	28					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	118030617	118030617	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118030617C>T	ENST00000439649.3	-	3	418	c.51G>A	c.(49-51)ctG>ctA	p.L17L	GFRA1_ENST00000355422.6_Silent_p.L17L|GFRA1_ENST00000369236.1_Silent_p.L17L	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	17					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTTCGGCCGACAGGAGCAAGT	0.711000													11	14					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38522377	38522377	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38522377C>T	ENST00000332509.3	-	10	1611		c.e10+1		PLA2G6_ENST00000335539.3_Splice_Site|PLA2G6_ENST00000490473.1_Splice_Site|PLA2G6_ENST00000402064.1_Splice_Site	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)						cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	GATCCACTTACGTCCGCTTCT	0.622000													12	22					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155232632	155232632	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:155232632C>T	ENST00000460012.1	-	12	1779	c.1422G>A	c.(1420-1422)agG>agA	p.R474R	PLCH1_ENST00000494598.1_Silent_p.R492R|PLCH1_ENST00000447496.2_Silent_p.R492R|PLCH1_ENST00000414191.1_Silent_p.R474R|PLCH1_ENST00000340059.7_Silent_p.R492R|PLCH1_ENST00000334686.6_Silent_p.R474R			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	492					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCAGTTTTTTCCTTATGAAAG	0.388000													26	27					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839513	27839513	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:27839513C>T	ENST00000356790.2	+	3	335	c.90C>T	c.(88-90)gaC>gaT	p.D30D		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	30										NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						ATGCTCTGGACATTTTAGAAG	0.512000													10	3					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54570759	54570759	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:54570759G>A	ENST00000251636.5	-	15	2655	c.2507C>T	c.(2506-2508)gCt>gTt	p.A836V	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	836							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GTATAGAATAGCATGCTGAGT	0.373000													58	72					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33237579	33237579	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33237579G>A	ENST00000401073.2	+	6	2869	c.2799G>A	c.(2797-2799)gcG>gcA	p.A933A	KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373481.3_Silent_p.A885A|KIAA1522_ENST00000373480.1_Silent_p.A874A	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	874	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TCCATGCTGCGGTCCGACTCA	0.711000													6	6					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5047489	5047489	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5047489C>T	ENST00000159111.4	+	6	653	c.435C>T	c.(433-435)gaC>gaT	p.D145D	KDM4B_ENST00000592175.1_3'UTR|KDM4B_ENST00000536461.1_Silent_p.D145D|KDM4B_ENST00000381759.4_Silent_p.D145D	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	145					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CCCCACAGGACGTGGCCCAGT	0.677000													18	13					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137717276	137717276	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137717276C>T	ENST00000314358.5	+	6	977	c.777C>T	c.(775-777)agC>agT	p.S259S		NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	259					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						CGCCTCAAAGCGAGGTACAGT	0.428000													20	19					0	0	1	0	0
NPIPB15	440348	broad.mit.edu	37	16	74425611	74425611	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:74425611G>A	ENST00000429990.1	+	7	1061	c.965G>A	c.(964-966)tGt>tAt	p.C322Y						nuclear pore complex interacting protein family, member B15																		CTGAAGGACTGTCTCTTTGTC	0.522000													35	224					0	0	1	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18636790	18636790	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18636790G>T	ENST00000336349.5	-	3	1266	c.1031C>A	c.(1030-1032)tCt>tAt	p.S344Y		NM_194285.2	NP_919261.2	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	344	Ser-rich.									breast(4)|cervix(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|skin(1)|stomach(1)	30						ATGGGACAGAGATTTTTTGGC	0.537000													56	86					9.55421e-19	1.05525e-18	1	1	0
REPIN1	29803	broad.mit.edu	37	7	150069766	150069766	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150069766G>A	ENST00000397281.2	+	4	1925	c.1436G>A	c.(1435-1437)cGc>cAc	p.R479H	REPIN1_ENST00000489432.2_Missense_Mutation_p.R536H|REPIN1_ENST00000479668.1_3'UTR|REPIN1_ENST00000444957.1_Missense_Mutation_p.R479H|REPIN1_ENST00000540729.1_Missense_Mutation_p.R479H|REPIN1_ENST00000425389.2_Missense_Mutation_p.R479H	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	479					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			GCGCACCGGCGCATCCACACC	0.701000													20	27					0	0	1	0	0
HEATR5A	25938	broad.mit.edu	37	14	31855778	31855778	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:31855778G>T	ENST00000543095.2	-	9	1377	c.1193C>A	c.(1192-1194)gCc>gAc	p.A398D	HEATR5A_ENST00000404677.3_Missense_Mutation_p.A398D|HEATR5A_ENST00000439727.1_Missense_Mutation_p.A105D|HEATR5A_ENST00000389961.3_Missense_Mutation_p.A392D|HEATR5A_ENST00000439348.1_Missense_Mutation_p.A392D	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	392							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		ACTCATTACGGCATCTGATAG	0.373000													37	70					2.05212e-20	2.27512e-20	1	1	0
ZNF525	170958	broad.mit.edu	37	19	53884662	53884662	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53884662G>A	ENST00000467003.1	+	4	923	c.722G>A	c.(721-723)gGc>gAc	p.G241D	ZNF525_ENST00000593918.1_Intron|ZNF525_ENST00000475179.1_Intron|ZNF525_ENST00000474037.1_Missense_Mutation_p.G277D					zinc finger protein 525											endometrium(3)|kidney(3)|lung(3)	9						AATGAGTGTGGCAAGTCCTTC	0.418000													30	49					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40321646	40321646	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40321646C>T	ENST00000264661.3	-	9	1771	c.1439G>A	c.(1438-1440)cGc>cAc	p.R480H	KCNH4_ENST00000607371.1_Missense_Mutation_p.R480H	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	480					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CGAGTACATGCGCTGGATGAT	0.667000													19	22					0	0	1	0	0
PRKCE	5581	broad.mit.edu	37	2	46203588	46203588	+	Missense_Mutation	SNP	C	C	T	rs144454815	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:46203588C>T	ENST00000306156.3	+	3	760	c.433C>T	c.(433-435)Cgt>Tgt	p.R145C		NM_005400.2	NP_005391.1	Q02156	KPCE_HUMAN	protein kinase C, epsilon	145					activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity		MBOAT2/PRKCE(2)	breast(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(13)|ovary(3)|upper_aerodigestive_tract(2)	34		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			CAATGAAGAGCGTGTGTTCAG	0.577000													33	36					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18375974	18375974	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18375974G>A	ENST00000392413.3	-	3	2591	c.2376C>T	c.(2374-2376)agC>agT	p.S792S	KIAA1683_ENST00000600359.2_Silent_p.S746S|KIAA1683_ENST00000600328.2_Silent_p.S792S	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	792						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						AGGGTGGGGCGCTGAGGCCAC	0.682000													44	72					0	0	1	0	0
BSCL2	26580	broad.mit.edu	37	11	62458558	62458558	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62458558G>A	ENST00000433053.1	-	9	1617	c.1061C>T	c.(1060-1062)gCt>gTt	p.A354V	BSCL2_ENST00000407022.3_Missense_Mutation_p.A290V|BSCL2_ENST00000421906.1_Missense_Mutation_p.A290V|RP11-831H9.16_ENST00000403734.2_3'UTR|BSCL2_ENST00000403550.1_Missense_Mutation_p.A290V|BSCL2_ENST00000360796.5_Missense_Mutation_p.A354V|BSCL2_ENST00000278893.7_Missense_Mutation_p.L243F|BSCL2_ENST00000405837.1_Missense_Mutation_p.A354V			Q96G97	BSCL2_HUMAN	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	290					cell death	integral to endoplasmic reticulum membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	12						TGGCTGATGAGCAGAGATCCT	0.537000													20	28					0	0	1	0	0
TMEM184A	202915	broad.mit.edu	37	7	1586670	1586670	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:1586670G>A	ENST00000297477.5	-	9	1476	c.1160C>T	c.(1159-1161)aCc>aTc	p.T387I		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	387						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		GCTGGGGTGGGTGCCGGGCCT	0.711000													6	6					0	0	1	0	0
RYK	6259	broad.mit.edu	37	3	133941272	133941272	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:133941272G>A	ENST00000296084.4	-	3	337	c.338C>T	c.(337-339)gCg>gTg	p.A113V	RYK_ENST00000427044.2_5'UTR	NM_001005861.2|NM_002958.3	NP_001005861.1|NP_002949.2	P34925	RYK_HUMAN	receptor-like tyrosine kinase	112	WIF.				corpus callosum development|positive regulation of MAPKKK cascade|Wnt receptor signaling pathway	cytoplasm|integral to plasma membrane|nucleus	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(1)|ovary(3)	4						CTTGGACTTCGCATGCCAGGT	0.478000													30	50					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73075239	73075239	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:73075239G>A	ENST00000263674.3	+	17	5706	c.5356G>A	c.(5356-5358)Gtg>Atg	p.V1786M		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1786					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						CCAGGTGTTTGTGTCTCTGGC	0.562000													59	71					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35399172	35399172	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35399172C>T	ENST00000378495.3	+	33	4064	c.3842C>T	c.(3841-3843)gCc>gTc	p.A1281V	UNC13B_ENST00000378496.4_Missense_Mutation_p.A1281V|UNC13B_ENST00000396787.1_Missense_Mutation_p.A1293V	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	1281	MHD2.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			ACCCTCTTTGCCACTGTGTGT	0.562000													41	66					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62849225	62849225	+	Missense_Mutation	SNP	G	G	A	rs147399182	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:62849225G>A	ENST00000512091.1	+	18	3683	c.2936G>A	c.(2935-2937)cGt>cAt	p.R979H	LPHN3_ENST00000508693.1_Missense_Mutation_p.R1047H|LPHN3_ENST00000514157.1_Missense_Mutation_p.R979H|LPHN3_ENST00000507164.1_Missense_Mutation_p.R1047H|LPHN3_ENST00000504896.1_Missense_Mutation_p.R979H|LPHN3_ENST00000506720.1_Missense_Mutation_p.R1047H|LPHN3_ENST00000511324.1_Missense_Mutation_p.R1047H|LPHN3_ENST00000545650.1_Missense_Mutation_p.R979H|LPHN3_ENST00000509896.1_Missense_Mutation_p.R1047H|LPHN3_ENST00000508946.1_Missense_Mutation_p.R979H|LPHN3_ENST00000506746.1_Missense_Mutation_p.R1047H|LPHN3_ENST00000507625.1_Missense_Mutation_p.R1047H|LPHN3_ENST00000506700.1_Missense_Mutation_p.R979H|LPHN3_ENST00000514996.1_Missense_Mutation_p.R979H|LPHN3_ENST00000514591.1_Missense_Mutation_p.R979H			Q9HAR2	LPHN3_HUMAN	latrophilin 3	966					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						GAACATTCACGTAGGAAATAC	0.458000													13	78					0	0	1	0	0
ECH1	1891	broad.mit.edu	37	19	39308102	39308102	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39308102C>T	ENST00000221418.4	-	4	695	c.463G>A	c.(463-465)Gtc>Atc	p.V155I		NM_001398.2	NP_001389.2			enoyl CoA hydratase 1, peroxisomal											cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	6	all_cancers(60;9.36e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CTCTCGATGACGTTGAAGGTC	0.592000													4	13					0	0	1	0	0
RPL5	6125	broad.mit.edu	37	1	93300375	93300375	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:93300375G>A	ENST00000370321.3	+	4	319	c.229G>A	c.(229-231)Gca>Aca	p.A77T		NM_000969.3	NP_000960.2	P46777	RL5_HUMAN	ribosomal protein L5	77					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		GATAGTCTGCGCAGCGTATGC	0.453000													5	85					0	0	1	0	0
C2orf44	80304	broad.mit.edu	37	2	24261860	24261860	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:24261860G>T	ENST00000295148.4	-	2	562	c.505C>A	c.(505-507)Ctg>Atg	p.L169M	C2orf44_ENST00000406895.3_Missense_Mutation_p.L169M	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	169							protein binding		C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCAGCCTCAGGCCATCCTGG	0.527000			T	ALK	NSCLC								10	13					6.40141e-05	6.5734e-05	1	1	0
MTIF2	4528	broad.mit.edu	37	2	55481258	55481258	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:55481258T>C	ENST00000394600.3	-	8	1319	c.583A>G	c.(583-585)Aca>Gca	p.T195A	MTIF2_ENST00000263629.4_Missense_Mutation_p.T195A|MTIF2_ENST00000403721.1_Missense_Mutation_p.T195A	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	195	G-domain.				regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						TCAAGTAATGTCGTTTTCCCG	0.443000													4	84					0	0	1	0	0
THEM5	284486	broad.mit.edu	37	1	151823652	151823652	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151823652C>T	ENST00000368817.5	-	3	472	c.341G>A	c.(340-342)cGc>cAc	p.R114H		NM_182578.3	NP_872384.1	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	114							hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGTGAAGATGCGACAGTCACC	0.522000													8	63					0	0	1	0	0
SMURF1	57154	broad.mit.edu	37	7	98634699	98634699	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:98634699C>T	ENST00000361125.1	-	16	2197	c.1878G>A	c.(1876-1878)aaG>aaA	p.K626K	SMURF1_ENST00000361368.2_Silent_p.K600K|AC004893.11_ENST00000468960.2_RNA	NM_020429.2	NP_065162.1	Q9HCE7	SMUF1_HUMAN	SMAD specific E3 ubiquitin protein ligase 1	626	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|urinary_tract(1)	25	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			CCTCCAGTTCCTTCTGGTCAA	0.552000											OREG0018188	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	51					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139904576	139904576	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139904576G>A	ENST00000265662.5	-	42	6501	c.6353_splice	c.e42-1	p.S2118_splice	ABCA2_ENST00000371605.3_Splice_Site_p.S2117_splice|ABCA2_ENST00000341511.6_Splice_Site_p.S2118_splice			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	2117	ABC transporter 2.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCTTCAGCACGCTGGGGACAC	0.711000													4	3					0	0	1	0	0
GPR15	2838	broad.mit.edu	37	3	98251277	98251277	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:98251277G>A	ENST00000284311.3	+	1	535	c.400G>A	c.(400-402)Gcc>Acc	p.A134T		NM_005290.1	NP_005281.1	P49685	GPR15_HUMAN	G protein-coupled receptor 15	134						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		CCGCTACCTGGCCATTGTGTG	0.537000													16	40					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075750	145075750	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145075750C>T	ENST00000369359.4	-	1	151	c.113G>A	c.(112-114)cGa>cAa	p.R38Q	PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R38Q|PDE4DIP_ENST00000369345.4_Missense_Mutation_p.R38Q|PDE4DIP_ENST00000369348.3_Missense_Mutation_p.R38Q			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTGAGGGGTTCGCGTCGCGTC	0.731000			T	PDGFRB	MPD								4	57					0	0	1	0	0
PRKCSH	5589	broad.mit.edu	37	19	11560163	11560163	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11560163C>T	ENST00000252455.2	+	17	1859	c.1523C>T	c.(1522-1524)aCg>aTg	p.T508M	PRKCSH_ENST00000587327.1_Missense_Mutation_p.T505M|PRKCSH_ENST00000589838.1_Missense_Mutation_p.T508M|PRKCSH_ENST00000591462.1_Missense_Mutation_p.T505M|PRKCSH_ENST00000412601.1_Missense_Mutation_p.T505M|PRKCSH_ENST00000592741.1_Missense_Mutation_p.T515M	NM_002743.2	NP_002734.2	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H	508					innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding	p.T508M(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(3)	19						GAGCTGATGACGCCAGCCGCC	0.667000													25	43					0	0	1	0	0
PFKP	5214	broad.mit.edu	37	10	3150938	3150938	+	Missense_Mutation	SNP	G	G	A	rs142802088		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:3150938G>A	ENST00000381075.2	+	11	1116	c.892G>A	c.(892-894)Ggg>Agg	p.G298R	PFKP_ENST00000381125.4_Missense_Mutation_p.G306R	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	306					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		GACCATCCTCGGGCACGTGCA	0.567000													21	42					0	0	1	0	0
APBB3	10307	broad.mit.edu	37	5	139942036	139942036	+	Translation_Start_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:139942036G>T	ENST00000508496.2	-	0	387				APBB3_ENST00000412920.3_Missense_Mutation_p.L134M|APBB3_ENST00000511201.2_Missense_Mutation_p.L134M|APBB3_ENST00000356738.2_Missense_Mutation_p.L134M|APBB3_ENST00000507279.1_5'UTR|APBB3_ENST00000357560.4_Missense_Mutation_p.L134M|APBB3_ENST00000354402.5_Missense_Mutation_p.L134M|APBB3_ENST00000358580.5_Missense_Mutation_p.L134M			O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3							actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGGTGCCAGGTCCTCTTCA	0.587000													46	87					6.27289e-28	7.01837e-28	1	1	0
OR5T2	219464	broad.mit.edu	37	11	55999633	55999633	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55999633C>T	ENST00000313264.4	-	1	1104	c.1029G>A	c.(1027-1029)atG>atA	p.M343I		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	343					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TTTTCCCAAACATTTTTTTCA	0.318000													18	33					0	0	1	0	0
C10orf11	83938	broad.mit.edu	37	10	77795870	77795870	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:77795870C>A	ENST00000372499.1	+	2	367	c.152C>A	c.(151-153)aCc>aAc	p.T51N	C10orf11_ENST00000593699.1_3'UTR	NM_032024.3	NP_114413.1	Q9H2I8	CJ011_HUMAN	chromosome 10 open reading frame 11	51										endometrium(1)|large_intestine(4)|lung(4)|stomach(1)	10	Prostate(51;0.0095)|all_epithelial(25;0.0221)					AGACTGCATACCTTAACCCTC	0.577000											OREG0020279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	24					6.40141e-05	6.5734e-05	1	1	0
DNTTIP1	116092	broad.mit.edu	37	20	44433838	44433838	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:44433838C>T	ENST00000372622.3	+	9	725	c.657C>T	c.(655-657)gcC>gcT	p.A219A		NM_052951.2	NP_443183.1	Q9H147	TDIF1_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 1	219						nucleus				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9		Myeloproliferative disorder(115;0.0122)				GATCTCGAGCCAACAAGTAAG	0.448000													20	108					0	0	1	0	0
NDST2	8509	broad.mit.edu	37	10	75565362	75565362	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:75565362G>A	ENST00000299641.4	-	9	2330	c.1360C>T	c.(1360-1362)Cga>Tga	p.R454*	NDST2_ENST00000309979.6_Nonsense_Mutation_p.R577*	NM_003635.3	NP_003626.1	P52849	NDST2_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	577	Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	30	Prostate(51;0.0112)					AGGGGGCTTCGCTCCTGAGGG	0.512000													9	10					0	0	1	0	0
CYP4Z2P	0	broad.mit.edu	37	1	47325376	47325376	+	RNA	SNP	C	C	T	rs9429100	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47325376C>T	ENST00000505841.1	-	0	1153					NR_002788.2																						GTCGAGTAACCGGGATATGTT	0.468000													17	80					0	0	1	0	0
FAM228A	653140	broad.mit.edu	37	2	24406394	24406394	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:24406394A>G	ENST00000295150.3	+	5	367	c.281A>G	c.(280-282)gAa>gGa	p.E94G	RP11-507M3.1_ENST00000584973.1_3'UTR	NM_001040710.1	NP_001035800.1			family with sequence similarity 228, member A																		GAACTTGAAGAAATAGAGAAG	0.433000													12	31					0	0	1	0	0
AOC3	8639	broad.mit.edu	37	17	41003967	41003967	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41003967C>T	ENST00000308423.2	+	1	767	c.607C>T	c.(607-609)Cac>Tac	p.H203Y		NM_003734.2	NP_003725.1	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3	203			H -> R (in dbSNP:rs630079).		amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	CTTCTACAAGCACCGGGGACG	0.592000													5	22					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19640046	19640046	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:19640046A>G	ENST00000438132.3	+	17	1786	c.1738A>G	c.(1738-1740)Aaa>Gaa	p.K580E	C16orf62_ENST00000448695.1_Missense_Mutation_p.K341E|C16orf62_ENST00000543152.1_Missense_Mutation_p.K240E|C16orf62_ENST00000542263.1_Missense_Mutation_p.K513E|C16orf62_ENST00000417362.2_Missense_Mutation_p.K424E|C16orf62_ENST00000251143.5_Missense_Mutation_p.K491E	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	491						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						CGAAGCTTGGAAAGTCATCAC	0.358000													5	86					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109793871	109793871	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109793871G>T	ENST00000271332.3	+	1	1231	c.1170G>T	c.(1168-1170)gaG>gaT	p.E390D		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	390	Cadherin 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TTTCTGTGGAGGATGACAATG	0.582000													25	29					8.58068e-18	9.45481e-18	1	1	0
ABCC11	85320	broad.mit.edu	37	16	48247384	48247384	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:48247384C>T	ENST00000394747.1	-	9	1675	c.1326G>A	c.(1324-1326)acG>acA	p.T442T	ABCC11_ENST00000353782.5_Silent_p.T442T|ABCC11_ENST00000394748.1_Silent_p.T442T|ABCC11_ENST00000356608.2_Silent_p.T442T|ABCC11_ENST00000537808.1_Silent_p.T442T	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	442	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ACTTGGAATTCGTGAGACCTT	0.547000													8	19					0	0	1	0	0
RALY	22913	broad.mit.edu	37	20	32660076	32660076	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:32660076C>T	ENST00000375114.3	+	3	774	c.196C>T	c.(196-198)Cgc>Tgc	p.R66C	RALY_ENST00000246194.3_Missense_Mutation_p.R66C|RALY_ENST00000493399.1_Intron	NM_007367.3	NP_031393.2	Q9UKM9	RALY_HUMAN	RALY heterogeneous nuclear ribonucleoprotein	66	RRM.					catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12						CTCCAATGAGCGCCATGCCCG	0.547000													16	30					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10296236	10296236	+	Missense_Mutation	SNP	G	G	A	rs144962215		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:10296236G>A	ENST00000403437.2	-	37	5469	c.5375C>T	c.(5374-5376)aCg>aTg	p.T1792M	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1792					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GTCCTTCACCGTCTGCTCCAG	0.557000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				4	120					0	0	1	0	0
STX7	8417	broad.mit.edu	37	6	132791752	132791752	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:132791752T>C	ENST00000367941.2	-	6	514	c.401A>G	c.(400-402)gAg>gGg	p.E134G	STX7_ENST00000367937.4_Missense_Mutation_p.E134G|STX7_ENST00000448348.3_5'UTR	NM_003569.2	NP_003560.2	O15400	STX7_HUMAN	syntaxin 7	134					intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|liver(1)|lung(5)	19	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		TGAGCTGTCCTCAGGAAAACT	0.313000													4	107					0	0	1	0	0
PPP4R1	9989	broad.mit.edu	37	18	9559585	9559585	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:9559585C>T	ENST00000400556.3	-	14	1933	c.1860G>A	c.(1858-1860)gcG>gcA	p.A620A	PPP4R1_ENST00000400555.3_Silent_p.A603A	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	620					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity	p.A620A(1)		large_intestine(1)|skin(2)	3						GATCTAACAACGCCTGAGGTA	0.433000													23	28					0	0	1	0	0
F7	2155	broad.mit.edu	37	13	113770092	113770092	+	Silent	SNP	C	C	T	rs6040	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113770092C>T	ENST00000375581.3	+	6	584	c.549C>T	c.(547-549)gaC>gaT	p.D183D	F7_ENST00000541084.1_Silent_p.D114D|F7_ENST00000346342.3_Silent_p.D161D	NM_000131.4	NP_000122.1	P08709	FA7_HUMAN	coagulation factor VII (serum prothrombin conversion accelerator)	183	EGF-like 2.		D -> N (in FA7D).		anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity			large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	TGCTGGCAGACGGGGTGTCCT	0.592000													8	15					0	0	1	0	0
MINK1	50488	broad.mit.edu	37	17	4798728	4798728	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4798728C>T	ENST00000355280.6	+	26	3365	c.3169C>T	c.(3169-3171)Cgg>Tgg	p.R1057W	MINK1_ENST00000347992.7_Missense_Mutation_p.R1028W|MINK1_ENST00000453408.3_Missense_Mutation_p.R1037W	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	1057	CNH.|Mediates interaction with RAP2A.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						ACTCATTGGGCGGCGACGCTT	0.622000													11	23					0	0	1	0	0
PPM1J	333926	broad.mit.edu	37	1	113255619	113255619	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:113255619C>T	ENST00000309276.6	-	3	651	c.476G>A	c.(475-477)gGg>gAg	p.G159E	PPM1J_ENST00000464951.1_5'UTR	NM_005167.5	NP_005158.5	Q5JR12	PPM1J_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1J	159	PP2C-like.									breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	14	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCTGCATGCCCATCAAATAG	0.537000													17	30					0	0	1	0	0
P4HA2	8974	broad.mit.edu	37	5	131530664	131530664	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:131530664G>A	ENST00000401867.1	-	15	2060	c.1492C>T	c.(1492-1494)Cga>Tga	p.R498*	P4HA2_ENST00000166534.4_Nonsense_Mutation_p.R498*|P4HA2_ENST00000360568.3_Nonsense_Mutation_p.R496*|P4HA2_ENST00000379100.2_Nonsense_Mutation_p.R496*|P4HA2_ENST00000379104.2_Nonsense_Mutation_p.R498*|P4HA2_ENST00000379086.1_Nonsense_Mutation_p.R496*			O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha polypeptide II	498	Fe2OG dioxygenase.					endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	TGTCTTGTTCGGTAGTCACCT	0.537000													17	25					0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25220641	25220641	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:25220641A>G	ENST00000276440.7	+	29	3072	c.3028A>G	c.(3028-3030)Aat>Gat	p.N1010D		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1010						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GATGGTGATGAATATGACTCA	0.448000													24	53					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112191640	112191640	+	Missense_Mutation	SNP	C	C	T	rs146750873		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:112191640C>T	ENST00000455480.2	+	20	3152	c.2975C>T	c.(2974-2976)gCg>gTg	p.A992V	ACAD10_ENST00000313698.4_Missense_Mutation_p.A961V	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	961							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups	p.A961V(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						GCGGACATCGCGCAGTCGCGC	0.642000											OREG0022130	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	23					0	0	1	0	0
P4HA2	8974	broad.mit.edu	37	5	131543528	131543528	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:131543528C>A	ENST00000401867.1	-	9	1521	c.953G>T	c.(952-954)aGg>aTg	p.R318M	P4HA2_ENST00000166534.4_Missense_Mutation_p.R318M|P4HA2_ENST00000360568.3_Missense_Mutation_p.R318M|P4HA2_ENST00000379100.2_Missense_Mutation_p.R318M|P4HA2_ENST00000379104.2_Missense_Mutation_p.R318M|P4HA2_ENST00000379086.1_Missense_Mutation_p.R318M			O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha polypeptide II	318						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	CTGTGGGGCCCTGTTGCCATG	0.552000													52	118					2.44813e-32	2.74628e-32	1	1	0
SSRP1	6749	broad.mit.edu	37	11	57099223	57099223	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57099223C>T	ENST00000278412.2	-	9	1408	c.1142G>A	c.(1141-1143)cGt>cAt	p.R381H		NM_003146.2	NP_003137.1	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	381					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|prostate(4)	23						AGTGGTACCACGAGCAAAGTT	0.522000													10	10					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109117131	109117131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:109117131C>T	ENST00000261483.4	+	9	2461	c.1409C>T	c.(1408-1410)gCg>gTg	p.A470V		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	470					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TTTTTTGATGCGCTGGATAAA	0.328000													16	24					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848844	54848844	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54848844G>A	ENST00000291759.4	-	5	835	c.779C>T	c.(778-780)gCc>gTc	p.A260V		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	260	Ig-like C2-type 3.					integral to membrane	receptor activity	p.A260fs*51(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GAGGCCATCGGCCCCCTCCTT	0.667000													11	18					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70514974	70514974	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:70514974C>T	ENST00000323786.5	-	19	2330	c.2309G>A	c.(2308-2310)cGc>cAc	p.R770H		NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	766	E domain; essential for proper cell surface glycosylation.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				CAGCACCTGGCGCACTTCAGC	0.597000													17	33					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2336723	2336723	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2336723G>T	ENST00000301732.5	-	22	3950	c.3250C>A	c.(3250-3252)Ctg>Atg	p.L1084M	ABCA3_ENST00000382381.3_Missense_Mutation_p.L1026M	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	1084					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				GCAGCCTGCAGGGCGCTCCGG	0.657000													22	24					0.000229342	0.000234539	1	1	0
USP38	84640	broad.mit.edu	37	4	144136036	144136036	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:144136036C>T	ENST00000307017.4	+	9	3413	c.2907C>T	c.(2905-2907)gaC>gaT	p.D969D	USP38_ENST00000510377.1_Silent_p.D969D	NM_032557.5	NP_115946.2	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	969					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	33	all_hematologic(180;0.158)					TAAATGGAGACCCACCTCTAC	0.328000													22	24					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228404812	228404812	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228404812G>A	ENST00000570156.2	+	8	2550	c.2476G>A	c.(2476-2478)Gtc>Atc	p.V826I	OBSCN_ENST00000284548.11_Missense_Mutation_p.V826I|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.V826I	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	826	Ig-like 8.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CGAAGCCCACGTCCACGTGCA	0.667000													26	31					0	0	1	0	0
CNNM3	26505	broad.mit.edu	37	2	97493559	97493559	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:97493559C>T	ENST00000305510.3	+	4	1639	c.1611C>T	c.(1609-1611)gaC>gaT	p.D537D	ANKRD23_ENST00000476975.1_Intron|CNNM3_ENST00000377060.3_Silent_p.D489D	NM_017623.4	NP_060093.3	Q8NE01	CNNM3_HUMAN	cyclin M3	537					ion transport	integral to membrane|plasma membrane	protein binding			NS(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)|skin(1)|urinary_tract(2)	13						TGAGGTTTGACGAGAGCAACC	0.577000													23	26					0	0	1	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68036701	68036701	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:68036701C>A	ENST00000329153.5	+	9	1538	c.1406C>A	c.(1405-1407)aCt>aAt	p.T469N		NM_020715.2	NP_065766.1	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	469						cytoskeleton	binding			endometrium(2)|kidney(4)|lung(12)|urinary_tract(1)	19				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		AAGAATGTCACTGTGCCTGTC	0.542000													3	10					0.004672	0.00472505	1	1	0
POLD1	5424	broad.mit.edu	37	19	50918754	50918754	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50918754G>A	ENST00000440232.2	+	21	2677	c.2624G>A	c.(2623-2625)cGc>cAc	p.R875H	POLD1_ENST00000595904.1_Missense_Mutation_p.R901H|POLD1_ENST00000599857.1_Missense_Mutation_p.R875H	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	875					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CTGTGCAACCGCATCGATATC	0.657000								DNA polymerases (catalytic subunits)					13	11					0	0	1	0	0
PLOD3	8985	broad.mit.edu	37	7	100859203	100859203	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100859203C>T	ENST00000223127.3	-	5	999	c.601G>A	c.(601-603)Gac>Aac	p.D201N		NM_001084.4	NP_001075.1	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	201					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	31	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	AGTCCTGGGTCCAGGTAGAGC	0.587000													10	19					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176019772	176019772	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176019772G>T	ENST00000510636.1	+	31	4057	c.3783G>T	c.(3781-3783)caG>caT	p.Q1261H	CDHR2_ENST00000506348.1_Missense_Mutation_p.Q1261H|CDHR2_ENST00000261944.5_Missense_Mutation_p.Q1261H	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	1261					homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						AGAACAGTCAGGAAATCAAGG	0.547000													13	28					4.93089e-13	5.3475e-13	1	1	0
CUL9	23113	broad.mit.edu	37	6	43172186	43172186	+	Silent	SNP	G	G	A	rs143759620		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43172186G>A	ENST00000252050.4	+	21	4332	c.4248G>A	c.(4246-4248)gcG>gcA	p.A1416A	CUL9_ENST00000372647.2_Silent_p.A1416A|CUL9_ENST00000354495.3_Silent_p.A1306A	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	1416					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						GTCGAGCAGCGTCCTTTGCTT	0.577000													50	73					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78349610	78349610	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78349610G>A	ENST00000582970.1	+	51	13268	c.13125G>A	c.(13123-13125)ctG>ctA	p.L4375L	CTD-2047H16.4_ENST00000575034.1_RNA|RNF213_ENST00000336301.6_Silent_p.L2448L|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000508628.2_Silent_p.L4424L	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGTTAACACTGTTTAGAGAGG	0.483000													9	48					0	0	1	0	0
CCDC77	84318	broad.mit.edu	37	12	539871	539871	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:539871T>C	ENST00000239830.4	+	7	731	c.552T>C	c.(550-552)tgT>tgC	p.C184C	CCDC77_ENST00000540180.1_Silent_p.C152C|CCDC77_ENST00000422000.1_Silent_p.C152C|CCDC77_ENST00000540344.1_3'UTR|CCDC77_ENST00000412006.2_Silent_p.C152C	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	184						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			TAGGTGAATGTGAGCAGAGTG	0.388000													14	75					0	0	1	0	0
KHNYN	23351	broad.mit.edu	37	14	24900107	24900107	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24900107G>T	ENST00000251343.5	+	2	310	c.171G>T	c.(169-171)gaG>gaT	p.E57D	CBLN3_ENST00000555436.1_5'UTR|KHNYN_ENST00000556842.1_Missense_Mutation_p.E57D|KHNYN_ENST00000553935.1_Missense_Mutation_p.E57D			O15037	KHNYN_HUMAN	KH and NYN domain containing	57										kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(3)	24						TGCAGCTGGAGGGCCCCAAGG	0.647000													9	9					0.000274275	0.000279654	1	1	0
MYH9	4627	broad.mit.edu	37	22	36684456	36684456	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36684456G>A	ENST00000216181.5	-	34	5004	c.4774C>T	c.(4774-4776)Cgg>Tgg	p.R1592W		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1592					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						TCCATCTCCCGCACCTGGGGG	0.622000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				13	17					0	0	1	0	0
ATF2	1386	broad.mit.edu	37	2	175939443	175939443	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:175939443G>A	ENST00000264110.2	-	14	1710	c.1412C>T	c.(1411-1413)gCt>gTt	p.A471V	ATF2_ENST00000409499.1_Missense_Mutation_p.A110V|ATF2_ENST00000409635.1_Missense_Mutation_p.A413V|ATF2_ENST00000487334.2_3'UTR|ATF2_ENST00000538946.1_3'UTR|ATF2_ENST00000392543.2_Missense_Mutation_p.A92V|ATF2_ENST00000426833.3_Missense_Mutation_p.A453V|ATF2_ENST00000392544.1_Missense_Mutation_p.A471V|ATF2_ENST00000409437.1_Missense_Mutation_p.A355V|ATF2_ENST00000345739.5_Missense_Mutation_p.A413V	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2	471					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			AGTGGCTACAGCTTCTGCCTT	0.517000													20	35					0	0	1	0	0
BRCA1	672	broad.mit.edu	37	17	41244008	41244008	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41244008G>A	ENST00000309486.4	-	9	3679	c.2652C>T	c.(2650-2652)agC>agT	p.S884S	BRCA1_ENST00000346315.3_Silent_p.S1180S|BRCA1_ENST00000493795.1_Silent_p.S1133S|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000471181.2_Silent_p.S1180S|BRCA1_ENST00000357654.3_Silent_p.S1180S|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000354071.3_Silent_p.S1180S	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	1180					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTTTCTGGACGCTTTTGCTAA	0.438000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			7	36					0	0	1	0	0
CTNNA1	1495	broad.mit.edu	37	5	138269727	138269727	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:138269727C>T	ENST00000302763.7	+	18	2760	c.2670C>T	c.(2668-2670)caC>caT	p.H890H	CTNNA1_ENST00000518825.1_3'UTR|CTNNA1_ENST00000540387.1_Silent_p.H520H|CTNNA1_ENST00000355078.5_Silent_p.H787H	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	890					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding	p.H890H(1)		NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AGAAGAAGCACGTGAACCCGG	0.542000													7	25					0	0	1	0	0
KDM3A	55818	broad.mit.edu	37	2	86707425	86707425	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:86707425A>G	ENST00000409556.1	+	17	2817	c.2452A>G	c.(2452-2454)Aca>Gca	p.T818A	KDM3A_ENST00000409064.1_Missense_Mutation_p.T818A|KDM3A_ENST00000312912.5_Missense_Mutation_p.T818A|KDM3A_ENST00000542128.1_Missense_Mutation_p.T766A			Q9Y4C1	KDM3A_HUMAN	lysine (K)-specific demethylase 3A	818					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						TCCAGCCAGCACATCTCCTCT	0.542000													3	24					0	0	1	0	0
PFAS	5198	broad.mit.edu	37	17	8158851	8158851	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8158851C>T	ENST00000314666.6	+	5	549	c.416C>T	c.(415-417)gCc>gTc	p.A139V	PFAS_ENST00000545834.1_Intron	NM_012393.2	NP_036525.1	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	139					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAGGTGGAAGCCATTGCTCTG	0.582000													8	24					0	0	1	0	0
SPAM1	0	broad.mit.edu	37	7	123595095	123595095	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:123595095T>C	ENST00000340011.5	+	4	1356	c.999T>C	c.(997-999)gcT>gcC	p.A333A	SPAM1_ENST00000223028.7_Silent_p.A333A|SPAM1_ENST00000439500.1_Silent_p.A333A|SPAM1_ENST00000460182.1_Silent_p.A333A|SPAM1_ENST00000402183.2_Silent_p.A333A	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	333					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	CTCTGGGTGCTTCTGGAATTG	0.348000													42	82					0	0	1	0	0
C9orf47	286223	broad.mit.edu	37	9	91606884	91606884	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:91606884C>T	ENST00000375851.2	+	3	666	c.533C>T	c.(532-534)tCg>tTg	p.S178L	C9orf47_ENST00000375850.3_Missense_Mutation_p.S230L|C9orf47_ENST00000334490.5_Missense_Mutation_p.S197L|S1PR3_ENST00000358157.2_Intron	NM_001001938.3|NM_001142413.1	NP_001001938.1|NP_001135885.1	Q6ZRZ4	CI047_HUMAN	chromosome 9 open reading frame 47	197						extracellular region				endometrium(1)|large_intestine(1)|liver(1)|lung(1)	4						TTCCATCAGTCGTTTTCCTTG	0.542000													16	31					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	71002999	71002999	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:71002999C>T	ENST00000354624.5	+	7	886	c.753C>T	c.(751-753)gaC>gaT	p.D251D	HKDC1_ENST00000395086.2_Silent_p.D251D	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	251					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TGGAGGGCGACGAGGGCAGGA	0.587000													37	49					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146720092	146720092	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:146720092C>T	ENST00000392299.2	+	8	2387	c.1917C>T	c.(1915-1917)ttC>ttT	p.F639F	GRM1_ENST00000355289.4_Silent_p.F639F|GRM1_ENST00000282753.1_Silent_p.F639F|GRM1_ENST00000507907.1_Silent_p.F639F|GRM1_ENST00000492807.2_Silent_p.F639F|GRM1_ENST00000361719.2_Silent_p.F639F			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	639					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CTGGCATCTTCCTTGGTTATG	0.517000													4	123					0	0	1	0	0
OR5T2	219464	broad.mit.edu	37	11	56000473	56000473	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:56000473C>A	ENST00000313264.4	-	1	264	c.189G>T	c.(187-189)caG>caT	p.Q63H		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					AGAAGATAGTCTGCAGTTCAA	0.383000													13	23					0.000219431	0.000224427	1	1	0
DOCK7	85440	broad.mit.edu	37	1	63099177	63099177	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:63099177C>A	ENST00000251157.5	-	10	1141	c.1108G>T	c.(1108-1110)Gcc>Tcc	p.A370S	DOCK7_ENST00000340370.5_Missense_Mutation_p.A370S|DOCK7_ENST00000404627.2_Missense_Mutation_p.A370S	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	370					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						ACCTTGGTGGCATCTGCTTCT	0.363000													6	128					2.7689e-08	2.91998e-08	1	1	0
RAD9B	144715	broad.mit.edu	37	12	110960163	110960163	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:110960163G>T	ENST00000409246.1	+	10	1181	c.856G>T	c.(856-858)Gaa>Taa	p.E286*	RAD9B_ENST00000409425.1_Nonsense_Mutation_p.E286*|RAD9B_ENST00000409778.3_Nonsense_Mutation_p.E289*|RAD9B_ENST00000392672.4_Nonsense_Mutation_p.E358*|RAD9B_ENST00000409300.1_Nonsense_Mutation_p.E358*			Q6WBX8	RAD9B_HUMAN	RAD9 homolog B (S. pombe)	355					cell cycle checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding			endometrium(1)|large_intestine(2)|lung(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	7						TGAAGTATCAGAAAGCAGTGT	0.438000													7	7					0.000274275	0.000279654	1	1	0
CTHRC1	115908	broad.mit.edu	37	8	104388156	104388156	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:104388156T>C	ENST00000330295.5	+	2	483	c.341T>C	c.(340-342)tTg>tCg	p.L114S	CTHRC1_ENST00000520337.1_Missense_Mutation_p.L100S|CTHRC1_ENST00000415886.2_Missense_Mutation_p.L114S	NM_138455.3	NP_612464.1	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	114						collagen				endometrium(1)|large_intestine(5)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			TGGAGTTCATTGAATTATGGC	0.383000													6	14					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128390869	128390869	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128390869G>T	ENST00000389524.4	+	39	5420	c.5367G>T	c.(5365-5367)gaG>gaT	p.E1789D	MYO7B_ENST00000428314.1_Missense_Mutation_p.E1788D|MYO7B_ENST00000409816.2_Missense_Mutation_p.E1788D|MYO7B_ENST00000409090.1_Missense_Mutation_p.E641D			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1788	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ACCAGGTGGAGGTGGAGGCCG	0.667000													6	15					0.248553	0.248844	1	1	0
ZYG11B	79699	broad.mit.edu	37	1	53261994	53261994	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:53261994G>A	ENST00000294353.6	+	7	1510	c.1365G>A	c.(1363-1365)tgG>tgA	p.W455*	ZYG11B_ENST00000443756.2_Nonsense_Mutation_p.W455*|ZYG11B_ENST00000545132.1_Nonsense_Mutation_p.W455*	NM_024646.2	NP_078922.1	Q9C0D3	ZY11B_HUMAN	zyg-11 family member B, cell cycle regulator	455							protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	30						TCATGCAGTGGCTTTGCAACC	0.443000													13	19					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32633053	32633053	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:32633053C>T	ENST00000242310.4	-	1	2614	c.2525G>A	c.(2524-2526)cGg>cAg	p.R842Q		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	842					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCGTATCCTCCGTGGCCGATC	0.463000													38	84					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	708965	708965	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:708965G>A	ENST00000549091.1	+	24	3057	c.2965G>A	c.(2965-2967)Gca>Aca	p.A989T	WDR90_ENST00000293879.4_Missense_Mutation_p.A989T	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	989										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				GGTCCTCAGCGCAGGGGACGC	0.647000													25	42					0	0	1	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45485814	45485814	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:45485814C>T	ENST00000359600.5	-	13	2824	c.2619G>A	c.(2617-2619)atG>atA	p.M873I		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	873							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					AGGTCATCCGCATCACCTGGG	0.517000													9	18					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61575066	61575066	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:61575066G>A	ENST00000398571.2	-	15	2300	c.2224C>T	c.(2224-2226)Cga>Tga	p.R742*		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	742					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			ATAAATTGTCGACAATTAAAT	0.428000													38	41					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2830794	2830794	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:2830794G>A	ENST00000520002.1	-	58	9326	c.8771C>T	c.(8770-8772)cCg>cTg	p.P2924L	CSMD1_ENST00000400186.3_Missense_Mutation_p.P2866L|CSMD1_ENST00000602723.1_Missense_Mutation_p.P2866L|CSMD1_ENST00000602557.1_Missense_Mutation_p.P2924L|CSMD1_ENST00000537824.1_Missense_Mutation_p.P2923L|CSMD1_ENST00000542608.1_Missense_Mutation_p.P2865L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2924	Sushi 22.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGGGGTCCCCGGATCACCACA	0.473000													37	62					0	0	1	0	0
SV2A	0	broad.mit.edu	37	1	149879689	149879689	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:149879689G>A	ENST00000369146.3	-	9	1939	c.1449C>T	c.(1447-1449)cgC>cgT	p.R483R	SV2A_ENST00000369145.1_Silent_p.R483R	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	483					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	ACACTTTGGTGCGGGATGCGT	0.517000													16	98					0	0	1	0	0
EIF4EBP2	1979	broad.mit.edu	37	10	72179743	72179743	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:72179743C>T	ENST00000373218.4	+	2	242	c.219C>T	c.(217-219)tgC>tgT	p.C73C		NM_004096.4	NP_004087.1	Q13542	4EBP2_HUMAN	eukaryotic translation initiation factor 4E binding protein 2	73					negative regulation of translational initiation|translation		eukaryotic initiation factor 4E binding			large_intestine(1)	1						CCCCACCCTGCCACCTGCCCA	0.448000													37	40					0	0	1	0	0
TOPORS	10210	broad.mit.edu	37	9	32542457	32542457	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:32542457C>T	ENST00000360538.2	-	3	2182	c.2066G>A	c.(2065-2067)cGt>cAt	p.R689H	TOPORS_ENST00000379858.1_Missense_Mutation_p.R624H	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	689	Arg-rich.|Interaction with TOP1.|Interaction with p53/TP53.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TAAATAATAACGATCTCTATT	0.388000													23	99					0	0	1	0	0
GGNBP2	79893	broad.mit.edu	37	17	34943623	34943623	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:34943623C>T	ENST00000304718.4	+	13	2154	c.1838C>T	c.(1837-1839)aCg>aTg	p.T613M		NM_024835.3	NP_079111.1	Q9H3C7	GGNB2_HUMAN	gametogenetin binding protein 2	613					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)	38		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		CCTACAGAAACGTTGTTTGGT	0.463000													55	79					0	0	1	0	0
FAM212A	389119	broad.mit.edu	37	3	49842153	49842153	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49842153C>T	ENST00000333323.4	+	2	730	c.597C>T	c.(595-597)aaC>aaT	p.N199N		NM_203370.1	NP_976248.1	Q96EL1	CC054_HUMAN	family with sequence similarity 212, member A	197																	TGGTGCACAACTGGATGGAGC	0.627000													16	28					0	0	1	0	0
VHL	7428	broad.mit.edu	37	3	10191469	10191469	+	Splice_Site	SNP	A	A	G	rs5030816		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:10191469A>G	ENST00000256474.2	+	3	1303		c.e3-1		VHL_ENST00000345392.2_Splice_Site|VHL_ENST00000477538.1_Splice_Site	NM_000551.3	NP_000542.1	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase						anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.?(8)		adrenal_gland(25)|autonomic_ganglia(3)|central_nervous_system(2)|endometrium(6)|kidney(1662)|large_intestine(14)|lung(6)|pancreas(18)|paratesticular_tissues(1)|pleura(1)|skin(1)|soft_tissue(24)|thyroid(3)|upper_aerodigestive_tract(3)	1769				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		TTGCCCTTCCAGTGTATACTC	0.498000		1	"""D, Mis, N, F, S"""		"""renal, hemangioma, pheochromocytoma"""	"""renal, hemangioma, pheochromocytoma"""			von Hippel-Lindau disease;Pheochromocytoma (Adrenal), Familial;Chuvash Polycythemia				14	22					0	0	1	0	0
BBS12	166379	broad.mit.edu	37	4	123665162	123665162	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:123665162G>A	ENST00000542236.1	+	3	2496	c.2115G>A	c.(2113-2115)acG>acA	p.T705T	BBS12_ENST00000314218.3_Silent_p.T705T	NM_001178007.1	NP_001171478.1	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	705					cellular protein metabolic process	cilium	ATP binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|prostate(4)	21						AGGAATTAACGGGCTTTCTAT	0.348000									Bardet-Biedl syndrome				31	44					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121958203	121958203	+	Missense_Mutation	SNP	G	G	A	rs143991157		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:121958203G>A	ENST00000379692.4	-	4	1449	c.923C>T	c.(922-924)aCg>aTg	p.T308M		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	308	Fibronectin type-III 1.									breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						GTAGTACTGCGTGTCGGGTTT	0.458000													12	62					0	0	1	0	0
TADA2A	6871	broad.mit.edu	37	17	35836996	35836996	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:35836996C>T	ENST00000394395.2	+	16	1414	c.1241C>T	c.(1240-1242)gCg>gTg	p.A414V	TADA2A_ENST00000225396.6_Missense_Mutation_p.A414V	NM_001166105.1	NP_001159577.1	O75478	TAD2A_HUMAN	transcriptional adaptor 2A	414	SWIRM.				histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)|skin(1)	13						TTAAGACTGGCGCAGGCAAGA	0.443000													41	89					0	0	1	0	0
PGAM2	5224	broad.mit.edu	37	7	44104760	44104760	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44104760C>T	ENST00000297283.3	-	1	426	c.369G>A	c.(367-369)ccG>ccA	p.P123P	AC017116.11_ENST00000445938.1_RNA	NM_000290.3	NP_000281.2	P15259	PGAM2_HUMAN	phosphoglycerate mutase 2 (muscle)	123	Poly-Pro.				gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity			large_intestine(2)|lung(4)|ovary(1)|stomach(1)	8						CCATCGGGGGCGGCGGGATGT	0.632000													11	18					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13737029	13737029	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:13737029C>T	ENST00000383314.2	+	5	814	c.574C>T	c.(574-576)Cga>Tga	p.R192*	RNMT_ENST00000543302.2_Nonsense_Mutation_p.R192*|RNMT_ENST00000262173.3_Nonsense_Mutation_p.R192*|RNMT_ENST00000589866.1_Nonsense_Mutation_p.R192*|RNMT_ENST00000592764.1_Nonsense_Mutation_p.R192*|RNMT_ENST00000535051.1_5'UTR			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	192					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						GGAAAAGGTACGACAGAAGAA	0.343000													12	25					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48694872	48694872	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48694872G>A	ENST00000352832.5	+	27	5365	c.4993G>A	c.(4993-4995)Gcc>Acc	p.A1665T	CACNA1G_ENST00000513689.2_Missense_Mutation_p.A1654T|CACNA1G_ENST00000507510.2_Missense_Mutation_p.A1699T|CACNA1G_ENST00000512389.1_Missense_Mutation_p.A1688T|CACNA1G_ENST00000514079.1_Missense_Mutation_p.A1706T|CACNA1G_ENST00000510115.1_Missense_Mutation_p.A1665T|CACNA1G_ENST00000510366.1_Missense_Mutation_p.A1647T|CACNA1G_ENST00000515411.1_Missense_Mutation_p.A1681T|CACNA1G_ENST00000515765.1_Missense_Mutation_p.A1688T|CACNA1G_ENST00000507896.1_Missense_Mutation_p.A1688T|CACNA1G_ENST00000503485.1_Missense_Mutation_p.A1665T|CACNA1G_ENST00000358244.5_Missense_Mutation_p.A1665T|CACNA1G_ENST00000513964.1_Missense_Mutation_p.A1654T|CACNA1G_ENST00000505165.1_Missense_Mutation_p.A1699T|CACNA1G_ENST00000515165.1_Missense_Mutation_p.A1699T|CACNA1G_ENST00000442258.2_Missense_Mutation_p.A1658T|CACNA1G_ENST00000360761.4_Missense_Mutation_p.A1676T|CACNA1G_ENST00000502264.1_Missense_Mutation_p.A1676T|CACNA1G_ENST00000514181.1_Missense_Mutation_p.A1681T|CACNA1G_ENST00000507336.1_Missense_Mutation_p.A1688T|CACNA1G_ENST00000507609.1_Missense_Mutation_p.A1699T|CACNA1G_ENST00000359106.5_Missense_Mutation_p.A1699T|CACNA1G_ENST00000514717.1_Missense_Mutation_p.A1642T|CACNA1G_ENST00000429973.2_Missense_Mutation_p.A1681T|CACNA1G_ENST00000354983.4_Missense_Mutation_p.A1665T	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1699					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity	p.A1699T(1)|p.A1665T(1)		breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CGAGGTCAACGCCTCGCTGCC	0.617000													10	31					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111156466	111156466	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:111156466C>T	ENST00000280325.4	+	4	545	c.398C>T	c.(397-399)aCg>aTg	p.T133M		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	133										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		CCACCCAGCACGAGTTGCCTC	0.632000													13	32					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360614	27360614	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27360614C>T	ENST00000335524.3	-	3	1109	c.584G>A	c.(583-585)tGc>tAc	p.C195Y		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	195										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTTGGCACGCATCTCTCCAC	0.657000													12	22					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240372032	240372032	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:240372032G>T	ENST00000319653.9	+	5	4150	c.3920_splice	c.e5+1	p.R1307_splice		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1307	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CATAGTAAAAGGTAACATGAA	0.418000													13	23					3.27435e-08	3.44876e-08	1	1	0
LLGL1	3996	broad.mit.edu	37	17	18137432	18137432	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18137432G>A	ENST00000316843.4	+	6	753	c.657G>A	c.(655-657)ctG>ctA	p.L219L		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	219					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					GCCGGGGCCTGCTGGTCATCT	0.627000													4	17					0	0	1	0	0
GTDC1	79712	broad.mit.edu	37	2	144903304	144903304	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:144903304G>A	ENST00000409214.1	-	5	460	c.182C>T	c.(181-183)aCc>aTc	p.T61I	GTDC1_ENST00000542155.1_Missense_Mutation_p.T61I|GTDC1_ENST00000392867.3_Missense_Mutation_p.T61I|GTDC1_ENST00000463875.2_5'UTR|GTDC1_ENST00000241391.5_Missense_Mutation_p.T61I|GTDC1_ENST00000409298.1_Missense_Mutation_p.T61I|GTDC1_ENST00000392869.1_Missense_Mutation_p.T61I|GTDC1_ENST00000344850.4_Missense_Mutation_p.T61I	NM_001006636.3	NP_001006637.1	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	61					biosynthetic process		transferase activity, transferring glycosyl groups			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(17)|ovary(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.0914)		TGCAAAGAGGGTCCTAGGAAA	0.458000													15	20					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38548889	38548889	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38548889G>A	ENST00000423485.1	-	30	4070	c.3912C>T	c.(3910-3912)gaC>gaT	p.D1304D		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	1304					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	AATTACTTTCGTCACTGCTCC	0.388000													41	90					0	0	1	0	0
ZNF324	25799	broad.mit.edu	37	19	58983156	58983156	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58983156G>A	ENST00000536459.2	+	4	2006	c.1297G>A	c.(1297-1299)Gcc>Acc	p.A433T	ZNF324_ENST00000535298.1_Missense_Mutation_p.A210T|ZNF324_ENST00000196482.3_Missense_Mutation_p.A433T			O75467	Z324A_HUMAN	zinc finger protein 324	433					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GTGCGGCCGCGCCTTTAGCCA	0.687000													22	32					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19455537	19455537	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:19455537G>A	ENST00000396229.2	+	4	1672	c.923G>A	c.(922-924)gGc>gAc	p.G308D	TMC5_ENST00000542583.2_Missense_Mutation_p.G308D|TMC5_ENST00000541464.1_Missense_Mutation_p.G308D|TMC5_ENST00000381414.4_Missense_Mutation_p.G308D	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	308						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AACTCATATGGCCACTCTCTG	0.488000													4	49					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2675634	2675634	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:2675634G>A	ENST00000399655.1	+	12	1820	c.1555G>A	c.(1555-1557)Gcc>Acc	p.A519T	CACNA1C_ENST00000491104.1_3'UTR|CACNA1C_ENST00000327702.7_Missense_Mutation_p.A519T|CACNA1C_ENST00000399601.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399638.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000335762.5_Missense_Mutation_p.A544T|CACNA1C_ENST00000406454.3_Missense_Mutation_p.A519T|CACNA1C_ENST00000399644.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399591.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399595.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399606.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399597.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000402845.3_Missense_Mutation_p.A519T|CACNA1C_ENST00000399617.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399634.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399603.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000480911.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399637.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399621.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000347598.4_Missense_Mutation_p.A519T|CACNA1C_ENST00000399649.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399629.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000399641.1_Missense_Mutation_p.A519T|CACNA1C_ENST00000344100.3_Missense_Mutation_p.A519T	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	519					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GAAGTGCCGCGCCGCAGTCAA	0.562000													6	1					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70674044	70674044	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:70674044C>T	ENST00000260126.3	-	3	1680	c.974G>A	c.(973-975)gGt>gAt	p.G325D	SLCO5A1_ENST00000528658.1_5'UTR|SLCO5A1_ENST00000530307.1_Missense_Mutation_p.G325D|SLCO5A1_ENST00000524945.1_Missense_Mutation_p.G325D	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	325						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			AACATAAAAACCAATAAGAAG	0.398000													8	52					0	0	1	0	0
ASTL	431705	broad.mit.edu	37	2	96789953	96789953	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:96789953C>T	ENST00000342380.2	-	9	931	c.932G>A	c.(931-933)cGg>cAg	p.R311Q		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	311					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						CTCCAAAAGCCGCTGCAGAGA	0.642000													8	20					0	0	1	0	0
ZNF280B	140883	broad.mit.edu	37	22	22842626	22842626	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:22842626G>A	ENST00000360412.2	-	4	1873	c.1098C>T	c.(1096-1098)caC>caT	p.H366H	ZNF280B_ENST00000406426.1_Silent_p.H366H	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		CCTGGGCAGTGTGGACATTTT	0.512000													33	64					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124521263	124521263	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:124521263G>A	ENST00000408936.3	+	5	785	c.603G>A	c.(601-603)gtG>gtA	p.V201V	DAB2IP_ENST00000259371.2_Silent_p.V173V|DAB2IP_ENST00000309989.1_Silent_p.V77V			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	201	C2.|PH.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						GGCGAGCGGTGCATCCCAACA	0.572000													10	2					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14057532	14057532	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:14057532C>T	ENST00000235372.7	+	3	903	c.47C>T	c.(46-48)gCt>gTt	p.A16V	PRDM2_ENST00000311066.5_Missense_Mutation_p.A16V|PRDM2_ENST00000376048.5_Missense_Mutation_p.A16V	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	16						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GAGACCCTGGCTGAGGTACCC	0.512000													9	57					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7404358	7404358	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7404358G>A	ENST00000322644.6	+	12	2380	c.1981G>A	c.(1981-1983)Ggt>Agt	p.G661S		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	661					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				CCTAGAGATGGGTCATGACAT	0.542000													20	28					0	0	1	0	0
SREBF1	6720	broad.mit.edu	37	17	17716711	17716711	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:17716711C>A	ENST00000355815.4	-	19	3444	c.3275G>T	c.(3274-3276)aGg>aTg	p.R1092M	SREBF1_ENST00000338854.5_Intron|SREBF1_ENST00000261646.5_Missense_Mutation_p.R1062M|SREBF1_ENST00000395757.1_Missense_Mutation_p.R808M	NM_001005291.2	NP_001005291.1	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription factor 1	1062					cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	14						TGCCCGCCGCCTCAGACTGCG	0.682000													6	5					0.00116845	0.0011864	1	1	0
ANK2	287	broad.mit.edu	37	4	114275899	114275899	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:114275899C>T	ENST00000357077.4	+	38	6178	c.6125C>T	c.(6124-6126)gCt>gTt	p.A2042V	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.A2009V|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2009					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAGAGAGAAGCTCAGAAAACA	0.463000													15	32					0	0	1	0	0
DUSP19	0	broad.mit.edu	37	2	183951789	183951789	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:183951789G>A	ENST00000354221.4	+	3	470	c.295G>A	c.(295-297)Gca>Aca	p.A99T	DUSP19_ENST00000469344.1_Intron|AC064871.3_ENST00000444562.1_RNA|DUSP19_ENST00000342619.6_Intron	NM_080876.3	NP_543152.1	Q8WTR2	DUS19_HUMAN	dual specificity phosphatase 19	99					JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|positive regulation of JNK cascade|positive regulation of JUN kinase activity	cytoplasm	JUN kinase phosphatase activity|MAP-kinase scaffold activity|mitogen-activated protein kinase kinase kinase binding|protein kinase activator activity|protein kinase inhibitor activity|protein tyrosine phosphatase activity			breast(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(4)|pancreas(1)	17						TCTTAATGTTGCATATGGAGT	0.338000													30	33					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24808870	24808870	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:24808870G>A	ENST00000395799.3	+	10	3750	c.3621G>A	c.(3619-3621)caG>caA	p.Q1207Q	TNRC6A_ENST00000315183.7_Silent_p.Q1207Q	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1207	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TTGTTAAACAGTTTTCAAACA	0.338000													11	21					0	0	1	0	0
TMCC3	57458	broad.mit.edu	37	12	94976111	94976111	+	Silent	SNP	C	C	T	rs140629808	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:94976111C>T	ENST00000261226.4	-	2	413	c.282G>A	c.(280-282)gcG>gcA	p.A94A	TMCC3_ENST00000551457.1_Silent_p.A63A	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	94						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						TCAGATACTCCGCAACATTCC	0.458000													44	83					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8448825	8448825	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8448825T>C	ENST00000360416.3	-	13	1510	c.1372A>G	c.(1372-1374)Aaa>Gaa	p.K458E	MYH10_ENST00000379980.4_Missense_Mutation_p.K464E|MYH10_ENST00000269243.4_Missense_Mutation_p.K448E|MYH10_ENST00000396239.1_Missense_Mutation_p.K448E	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	448	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CCCTGACGTTTGGTCCTATCC	0.443000													22	39					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153689978	153689978	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153689978C>T	ENST00000369682.3	+	3	1309	c.1134_splice	c.e3+1	p.T378_splice		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	378	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCATCAACACCGTGAGCCCCT	0.637000													35	11					0	0	1	0	0
HMGCL	3155	broad.mit.edu	37	1	24147063	24147063	+	Silent	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24147063G>C	ENST00000374483.4	-	3	677	c.6C>G	c.(4-6)ggC>ggG	p.G2G	HMGCL_ENST00000374490.3_Silent_p.G27G|HMGCL_ENST00000436439.2_Silent_p.G27G|HMGCL_ENST00000509389.1_5'UTR			P35914	HMGCL_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase	27					acetoacetic acid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA lyase activity|metal ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.0044)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.38e-24)|Colorectal(126;5.58e-08)|COAD - Colon adenocarcinoma(152;3.12e-06)|GBM - Glioblastoma multiforme(114;4.9e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000982)|KIRC - Kidney renal clear cell carcinoma(1967;0.0034)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0856)|LUSC - Lung squamous cell carcinoma(448;0.188)		TTGGTAAAGTGCCCATAGATG	0.398000													24	57					0	0	1	0	0
AP2A1	160	broad.mit.edu	37	19	50302734	50302734	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50302734C>T	ENST00000354293.5	+	9	1282	c.1116C>T	c.(1114-1116)acC>acT	p.T372T	AP2A1_ENST00000359032.5_Silent_p.T372T	NM_130787.2	NP_570603.2	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1 subunit	372					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)	19		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		ACATTGACACCGTCATCAATG	0.642000													7	13					0	0	1	0	0
MAP3K2	10746	broad.mit.edu	37	2	128065338	128065338	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128065338C>T	ENST00000409947.1	-	17	1959	c.1677G>A	c.(1675-1677)ccG>ccA	p.P559P	MAP3K2_ENST00000344908.5_Silent_p.P559P			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2	559	Protein kinase.				activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		CAGCCCAAGGCGGCTTTTCAG	0.408000													4	5					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159162426	159162426	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:159162426C>T	ENST00000368125.4	+	3	445	c.288C>T	c.(286-288)agC>agT	p.S96S	CADM3_ENST00000368124.4_Silent_p.S130S	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	96	Ig-like V-type.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					TCAGCATCAGCATCAGCAATG	0.527000													20	28					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	160982962	160982962	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:160982962C>T	ENST00000283249.2	-	11	2048	c.1811G>A	c.(1810-1812)tGc>tAc	p.C604Y	ITGB6_ENST00000428609.2_Missense_Mutation_p.C562Y|ITGB6_ENST00000409967.2_Intron|ITGB6_ENST00000409872.1_Missense_Mutation_p.C604Y			P18564	ITB6_HUMAN	integrin, beta 6	604	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						AGGGTTTGTGCAAACACACTT	0.552000													5	26					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129837346	129837346	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:129837346C>T	ENST00000421865.2	+	65	9272	c.9223C>T	c.(9223-9225)Cag>Tag	p.Q3075*		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	3075	Laminin G-like 5.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGACCTCAAGCAGTTTGGCCT	0.463000													57	112					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176825064	176825064	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176825064C>T	ENST00000324417.5	+	13	1788	c.1697C>T	c.(1696-1698)cCc>cTc	p.P566L	SLC34A1_ENST00000513614.1_3'UTR	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	566					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGTCGGAGTCCCGGGCACCTG	0.637000													14	57					0	0	1	0	0
RSRC1	51319	broad.mit.edu	37	3	158015856	158015856	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:158015856G>T	ENST00000464171.1	+	4	474	c.349G>T	c.(349-351)Gaa>Taa	p.E117*	RSRC1_ENST00000295930.3_Nonsense_Mutation_p.E175*|RSRC1_ENST00000312179.6_Nonsense_Mutation_p.E117*|RSRC1_ENST00000496268.1_3'UTR|RSRC1_ENST00000480820.1_Nonsense_Mutation_p.E175*|RSRC1_ENST00000475278.2_Nonsense_Mutation_p.E175*	NM_001271834.1	NP_001258763.1	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	175	Arg/Ser-rich.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|upper_aerodigestive_tract(1)	18			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			AGCTGGATTAGAACATCTGGT	0.308000													14	41					1.99824e-07	2.09433e-07	1	1	0
ANAPC2	29882	broad.mit.edu	37	9	140082419	140082419	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140082419G>A	ENST00000323927.2	-	2	258	c.254C>T	c.(253-255)gCc>gTc	p.A85V		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	85					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		GGAGATGTTGGCCTGCAGATC	0.607000													5	18					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34268983	34268983	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:34268983C>T	ENST00000346562.2	+	11	1448	c.1374C>T	c.(1372-1374)tcC>tcT	p.S458S	NPAS3_ENST00000356141.4_Silent_p.S490S|NPAS3_ENST00000551492.1_Silent_p.S495S|NPAS3_ENST00000548645.1_Silent_p.S460S|NPAS3_ENST00000357798.5_Silent_p.S477S	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GGAACCAGTCCGAGAACAGCG	0.637000													2	1					0	0	1	0	0
TRNAU1AP	54952	broad.mit.edu	37	1	28891266	28891266	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:28891266C>T	ENST00000373830.3	+	5	356	c.330C>T	c.(328-330)ggC>ggT	p.G110G	TRNAU1AP_ENST00000495995.1_3'UTR	NM_017846.4	NP_060316.1	Q9NX07	TSAP1_HUMAN	tRNA selenocysteine 1 associated protein 1	110	RRM 2.				selenocysteine incorporation	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(2)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	8						TGGATGATGGCATGCTGTATG	0.517000													45	63					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73474488	73474488	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:73474488C>T	ENST00000252034.7	+	24	1994	c.1595C>T	c.(1594-1596)gCc>gTc	p.A532V	CTB-51J22.1_ENST00000435932.1_RNA|ELN_ENST00000458204.1_Missense_Mutation_p.A522V|ELN_ENST00000380562.4_Missense_Mutation_p.A538V|ELN_ENST00000380553.4_Missense_Mutation_p.A396V|ELN_ENST00000320492.7_Missense_Mutation_p.A451V|ELN_ENST00000380576.5_Missense_Mutation_p.A513V|ELN_ENST00000414324.1_Missense_Mutation_p.A508V|ELN_ENST00000429192.1_Missense_Mutation_p.A518V|ELN_ENST00000358929.4_Missense_Mutation_p.A567V|ELN_ENST00000357036.5_Missense_Mutation_p.A537V|ELN_ENST00000320399.6_Missense_Mutation_p.A532V|ELN_ENST00000445912.1_Missense_Mutation_p.A532V|ELN_ENST00000380584.4_Intron|ELN_ENST00000380575.4_Missense_Mutation_p.A503V	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	561	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	AAATCCGCTGCCAAGGTGGCT	0.627000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						26	31					0	0	1	0	0
NDUFAF6	137682	broad.mit.edu	37	8	96047721	96047721	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:96047721C>T	ENST00000396113.1	+	9	1111	c.61C>T	c.(61-63)Cga>Tga	p.R21*	NDUFAF6_ENST00000396111.2_Nonsense_Mutation_p.R21*|NDUFAF6_ENST00000396124.4_Nonsense_Mutation_p.R113*|NDUFAF6_ENST00000286687.4_5'UTR|NDUFAF6_ENST00000542894.1_Nonsense_Mutation_p.R61*			Q330K2	CH038_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6	113					biosynthetic process	mitochondrion	transferase activity										TGGACTGATGCGAATGCAGTT	0.343000													23	43					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31614086	31614086	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:31614086C>T	ENST00000399332.1	-	16	3046	c.2558G>A	c.(2557-2559)cGt>cAt	p.R853H	HECTD1_ENST00000553700.1_Missense_Mutation_p.R853H	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	853					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CACTACTCCACGAGGCATGCT	0.353000													17	26					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20142838	20142838	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:20142838A>G	ENST00000263754.4	+	5	1184	c.729A>G	c.(727-729)acA>acG	p.T243T		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	243					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						AAAGGCAAACAATAGTTGAGT	0.413000													32	57					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65315230	65315230	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65315230C>T	ENST00000301873.5	-	13	2177	c.1909G>A	c.(1909-1911)Ggc>Agc	p.G637S	LTBP3_ENST00000322147.4_Missense_Mutation_p.G637S|LTBP3_ENST00000536982.1_Missense_Mutation_p.G263S|LTBP3_ENST00000532932.1_Missense_Mutation_p.G67S	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	637	Cys-rich.|EGF-like 4; calcium-binding (Potential).					extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						TTGTAGGAGCCGCCGGTGTTC	0.677000													9	5					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5111404	5111404	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5111404G>A	ENST00000381759.4	+	11	1341	c.1134G>A	c.(1132-1134)tcG>tcA	p.S378S	KDM4B_ENST00000536461.1_Intron|KDM4B_ENST00000159111.4_Intron			O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	384					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CCTGCGTATCGCCGCACAGAC	0.627000													6	41					0	0	1	0	0
HLX	3142	broad.mit.edu	37	1	221057870	221057870	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:221057870G>A	ENST00000366903.6	+	4	2792	c.1291G>A	c.(1291-1293)Ggc>Agc	p.G431S	HLX_ENST00000549319.1_Missense_Mutation_p.G217S	NM_021958.3	NP_068777.1	Q14774	HLX_HUMAN	H2.0-like homeobox	431	Ser-rich.				cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(9)|lung(11)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(131;0.00914)		cggcggcggcggcaatagttt	0.637000													8	8					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48761940	48761940	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:48761940C>A	ENST00000314191.2	-	54	7183	c.7127_splice	c.e54+1	p.R2376_splice	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Splice_Site_p.R2376_splice	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2377					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CAGCCCATACCTGTCTGCAAG	0.517000								Non-homologous end-joining					34	54					4.4194e-11	4.74656e-11	1	1	0
PCDHA5	0	broad.mit.edu	37	5	140202728	140202728	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140202728G>T	ENST00000529859.1	+	1	1368	c.1368G>T	c.(1366-1368)caG>caT	p.Q456H	PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.Q456H|PCDHA5_ENST00000529619.1_Missense_Mutation_p.Q456H|PCDHA2_ENST00000526136.1_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTTCGCGCAGCCCCAGTATA	0.672000													27	33					2.70662e-09	2.87175e-09	1	1	0
MACF1	23499	broad.mit.edu	37	1	39847733	39847733	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:39847733C>T	ENST00000564288.1	+	56	14534	c.13757C>T	c.(13756-13758)cCg>cTg	p.P4586L	MACF1_ENST00000567887.1_Missense_Mutation_p.P4623L|MACF1_ENST00000539005.1_Missense_Mutation_p.P2503L|MACF1_ENST00000372915.3_Missense_Mutation_p.P4591L|MACF1_ENST00000361689.2_Missense_Mutation_p.P2524L|MACF1_ENST00000317713.7_Missense_Mutation_p.P2524L|MACF1_ENST00000289893.4_Missense_Mutation_p.P3026L|MACF1_ENST00000545844.1_Missense_Mutation_p.P2524L			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	4591					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGCTCCGGCCGTGGCTGATG	0.552000													21	23					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50467923	50467923	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:50467923C>T	ENST00000331340.3	+	8	1313	c.1158C>T	c.(1156-1158)cgC>cgT	p.R386R	IKZF1_ENST00000349824.4_Silent_p.R243R|IKZF1_ENST00000359197.5_Silent_p.R344R|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000357364.4_Silent_p.R299R|IKZF1_ENST00000343574.5_Silent_p.R299R|IKZF1_ENST00000346667.4_Silent_p.R156R|IKZF1_ENST00000439701.1_Silent_p.R344R|IKZF1_ENST00000438033.1_Silent_p.R299R	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	386					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CCTCGGAGCGCGAGGCGTCCC	0.672000			"""D,T"""	BCL6	"""ALL, DLBCL"""								4	4					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26164705	26164705	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:26164705C>T	ENST00000335473.7	+	4	1072	c.822C>T	c.(820-822)ggC>ggT	p.G274G	MYO18B_ENST00000407587.2_Silent_p.G274G|MYO18B_ENST00000536101.1_Silent_p.G274G	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	274						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AAGGGCCCGGCGAGGGGGTGC	0.632000													3	7					0	0	1	0	0
OR8J1	219477	broad.mit.edu	37	11	56128085	56128085	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:56128085C>T	ENST00000303039.3	+	1	395	c.363C>T	c.(361-363)gaC>gaT	p.D121D		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					TGGCCTATGACCGCTATGTGG	0.488000													7	100					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97544634	97544634	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:97544634A>G	ENST00000370192.3	-	23	3076	c.2976T>C	c.(2974-2976)tgT>tgC	p.C992C		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	992	4Fe-4S ferredoxin-type 3.				'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AAACACTGAGACACAGAGTAC	0.463000													5	102					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82764162	82764162	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:82764162A>G	ENST00000423517.2	-	3	3041	c.2704T>C	c.(2704-2706)Tca>Cca	p.S902P	PCLO_ENST00000333891.8_Missense_Mutation_p.S902P	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	848	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AAACGCCTTGACTGCTCCTGA	0.547000													41	81					0	0	1	0	0
HABP4	22927	broad.mit.edu	37	9	99227684	99227684	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:99227684G>A	ENST00000375249.4	+	3	653	c.578G>A	c.(577-579)cGc>cAc	p.R193H	HABP4_ENST00000375251.3_Intron	NM_014282.2	NP_055097.2	Q5JVS0	HABP4_HUMAN	hyaluronan binding protein 4	193					platelet activation|platelet degranulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|extracellular region|nucleus	protein binding			NS(1)|cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13		Acute lymphoblastic leukemia(62;0.0169)|all_hematologic(171;0.214)				GGGGGTATGCGCGGCAGAGGC	0.483000													34	59					0	0	1	0	0
CLN3	1201	broad.mit.edu	37	16	28498783	28498783	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:28498783G>T	ENST00000569430.1	-	8	1273	c.454C>A	c.(454-456)Ctg>Atg	p.L152M	CLN3_ENST00000333496.9_Missense_Mutation_p.L128M|CLN3_ENST00000565316.1_Missense_Mutation_p.L152M|CLN3_ENST00000359984.7_Missense_Mutation_p.L152M|CLN3_ENST00000395653.4_Missense_Mutation_p.L52M|CLN3_ENST00000360019.2_Missense_Mutation_p.L152M|CLN3_ENST00000357806.7_Missense_Mutation_p.P125H|CLN3_ENST00000357857.9_Missense_Mutation_p.L98M|CLN3_ENST00000568224.1_Missense_Mutation_p.L74M|CLN3_ENST00000354630.5_Missense_Mutation_p.L152M|CLN3_ENST00000567963.1_Missense_Mutation_p.L152M|CLN3_ENST00000355477.5_Missense_Mutation_p.L152M|CLN3_ENST00000357076.5_Missense_Mutation_p.L152M|CLN3_ENST00000535392.1_Missense_Mutation_p.L74M			Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	152					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding			breast(1)|large_intestine(2)|lung(11)|upper_aerodigestive_tract(1)	15						TCACCACACAGGCTGGTCCCC	0.582000													8	10					1.76689e-08	1.86465e-08	1	1	0
NBPF10	100132406	broad.mit.edu	37	1	145299937	145299937	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145299937A>G	ENST00000342960.5	+	6	1021	c.986A>G	c.(985-987)tAc>tGc	p.Y329C	NBPF10_ENST00000369339.2_Intron|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Missense_Mutation_p.Y58C	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	329										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CAGAAGAAATACAGTAAGATC	0.423000													63	134					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133760700	133760700	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:133760700C>T	ENST00000318560.5	+	11	3404	c.3023C>T	c.(3022-3024)aCc>aTc	p.T1008I		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	1008	F-actin-binding.|Pro-rich.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CTCATATCAACCCGAGTGTCT	0.662000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								13	31					0	0	1	0	0
C7orf26	79034	broad.mit.edu	37	7	6639613	6639613	+	Missense_Mutation	SNP	G	G	A	rs149671282		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:6639613G>A	ENST00000344417.5	+	4	1001	c.734G>A	c.(733-735)cGc>cAc	p.R245H	C7orf26_ENST00000472693.1_3'UTR|C7orf26_ENST00000359073.5_Intron	NM_024067.2	NP_076972.2	Q96N11	CG026_HUMAN	chromosome 7 open reading frame 26	245			R -> C (in dbSNP:rs35534502).					p.R245L(1)		endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	11		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		GGATTGATCCGCTGGTGCGTG	0.517000													7	69					0	0	1	0	0
XPO6	23214	broad.mit.edu	37	16	28115914	28115914	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:28115914C>T	ENST00000304658.5	-	21	3399	c.2899G>A	c.(2899-2901)Gct>Act	p.A967T	XPO6_ENST00000565698.1_Missense_Mutation_p.A953T	NM_015171.2	NP_055986.1	Q96QU8	XPO6_HUMAN	exportin 6	967					protein export from nucleus		protein binding|protein transporter activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25						TGCTCCTCAGCGATCCCCCTC	0.582000													16	17					0	0	1	0	0
IPO7	10527	broad.mit.edu	37	11	9430101	9430101	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:9430101T>C	ENST00000379719.3	+	3	377	c.235T>C	c.(235-237)Tcc>Ccc	p.S79P		NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	79	Importin N-terminal.				interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		AGGGGATATATCCCCTTATAC	0.353000													28	41					0	0	1	0	0
ANKFY1	51479	broad.mit.edu	37	17	4145692	4145692	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4145692A>G	ENST00000341657.4	-	2	97	c.62T>C	c.(61-63)gTc>gCc	p.V21A	ANKFY1_ENST00000574367.1_Missense_Mutation_p.V21A|ANKFY1_ENST00000570535.1_Missense_Mutation_p.V63A|ANKFY1_ENST00000433651.1_Missense_Mutation_p.V21A	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	21						endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						CTGCAGCTTGACATACTCCTG	0.562000													46	60					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170459007	170459007	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:170459007G>A	ENST00000439128.2	-	18	2258	c.1618C>T	c.(1618-1620)Cga>Tga	p.R540*	NEK1_ENST00000511633.1_Nonsense_Mutation_p.R496*|NEK1_ENST00000512193.1_Nonsense_Mutation_p.R471*|NEK1_ENST00000510533.1_Nonsense_Mutation_p.R496*|NEK1_ENST00000507142.1_Nonsense_Mutation_p.R540*	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	540					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		TCCCGTTTTCGCTGCAGGAAC	0.388000													85	124					0	0	1	0	0
SEC24B	10427	broad.mit.edu	37	4	110448484	110448484	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:110448484G>A	ENST00000265175.5	+	18	3027	c.2972G>A	c.(2971-2973)cGg>cAg	p.R991Q	SEC24B_ENST00000399100.2_Missense_Mutation_p.R956Q|SEC24B_ENST00000504968.2_Missense_Mutation_p.R1021Q	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	991					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TTAGGTGAGCGGAGAATTAGA	0.353000													45	67					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872787	51872787	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:51872787C>A	ENST00000371497.5	+	2	3677	c.2790C>A	c.(2788-2790)gaC>gaA	p.D930E	TSHZ2_ENST00000329613.6_Missense_Mutation_p.D927E|TSHZ2_ENST00000603338.2_Missense_Mutation_p.D927E|RP4-678D15.1_ENST00000606932.1_RNA	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	930					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			ATTGCAGTGACTGTGCCTCCC	0.498000													15	22					6.31663e-08	6.64488e-08	1	1	0
KIAA0922	23240	broad.mit.edu	37	4	154517484	154517484	+	Silent	SNP	C	C	T	rs143841084		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:154517484C>T	ENST00000409663.3	+	20	2119	c.2067C>T	c.(2065-2067)ggC>ggT	p.G689G	KIAA0922_ENST00000440693.1_Silent_p.G606G|KIAA0922_ENST00000409959.3_Silent_p.G690G	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	689						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				AAAGGGTTGGCGTAGTTTTCA	0.418000													38	53					0	0	1	0	0
ITGB3BP	23421	broad.mit.edu	37	1	63912520	63912520	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:63912520A>G	ENST00000371092.3	-	9	669	c.609T>C	c.(607-609)cgT>cgC	p.R203R	ITGB3BP_ENST00000461681.1_Intron|ITGB3BP_ENST00000271002.10_Silent_p.R164R	NM_001206739.1	NP_001193668.1	Q13352	CENPR_HUMAN	integrin beta 3 binding protein (beta3-endonexin)	164					apoptosis|cell adhesion|CenH3-containing nucleosome assembly at centromere|induction of apoptosis by extracellular signals|mitotic prometaphase|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome, centromeric region|cytosol|membrane fraction|nucleoplasm	protein C-terminus binding|signal transducer activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	9						TGTCAAGATGACGTGATGCTA	0.313000													10	20					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85851323	85851323	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:85851323C>T	ENST00000383699.3	+	3	842	c.215C>T	c.(214-216)aCt>aTt	p.T72I	CADM2_ENST00000405615.2_Missense_Mutation_p.T65I|CADM2-AS2_ENST00000467225.1_RNA|CADM2_ENST00000407528.2_Missense_Mutation_p.T63I	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	63	Ig-like V-type.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GCTCAACAGACTCTGTACTTT	0.353000													22	36					0	0	1	0	0
TM4SF5	9032	broad.mit.edu	37	17	4675222	4675222	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4675222G>A	ENST00000270560.3	+	1	36	c.5G>A	c.(4-6)tGt>tAt	p.C2Y		NM_003963.2	NP_003954.2	O14894	T4S5_HUMAN	transmembrane 4 L six family member 5	2						integral to plasma membrane				large_intestine(2)|lung(3)|ovary(1)	6						CTCACCATGTGTACGGGAAAA	0.572000													6	114					0	0	1	0	0
WISP1	8840	broad.mit.edu	37	8	134203379	134203379	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:134203379C>T	ENST00000377863.2	+	1	53	c.17C>T	c.(16-18)aCg>aTg	p.T6M	WISP1_ENST00000519433.1_5'UTR|WISP1_ENST00000220856.6_Intron|WISP1_ENST00000517423.1_5'UTR|WISP1_ENST00000250160.6_5'UTR			O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	0					cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			GTGCCACTGACGTCCAGGCAT	0.682000													12	8					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103317441	103317441	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:103317441A>G	ENST00000520539.1	-	21	3305	c.2699T>C	c.(2698-2700)gTt>gCt	p.V900A	UBR5_ENST00000220959.4_Missense_Mutation_p.V900A|UBR5_ENST00000521922.1_Missense_Mutation_p.V894A	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	900					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTGCTCTAAAACAACCGCTTG	0.408000													52	84					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109625870	109625870	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:109625870T>C	ENST00000338432.7	+	13	2166	c.2047T>C	c.(2047-2049)Tac>Cac	p.Y683H	ACACB_ENST00000377848.3_Missense_Mutation_p.Y683H|ACACB_ENST00000377854.5_Missense_Mutation_p.Y683H			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	683	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CGTGTGGGGTTACTTCAGCGT	0.552000													21	34					0	0	1	0	0
PLGRKT	55848	broad.mit.edu	37	9	5361129	5361129	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:5361129G>T	ENST00000223864.2	-	5	492	c.271C>A	c.(271-273)Ctc>Atc	p.L91I		NM_018465.3	NP_060935.2	Q9HBL7	CI046_HUMAN	plasminogen receptor, C-terminal lysine transmembrane protein	91						integral to membrane											TGGTAGGTGAGGATAAAGCTT	0.348000													10	42					1.58986e-06	1.65464e-06	1	1	0
ESYT3	83850	broad.mit.edu	37	3	138178803	138178803	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:138178803G>A	ENST00000389567.4	+	6	851	c.665G>A	c.(664-666)cGg>cAg	p.R222Q	ESYT3_ENST00000289135.4_Missense_Mutation_p.R222Q	NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	222						integral to membrane|plasma membrane				breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						GGCACCCTGCGGGTCATCCTG	0.632000													3	38					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99697813	99697813	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:99697813G>A	ENST00000357195.3	-	3	518	c.509C>T	c.(508-510)cCt>cTt	p.P170L	BCL11B_ENST00000345514.2_Intron|BCL11B_ENST00000443726.2_Intron	NM_138576.2	NP_612808.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	170						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GGCACGCAGAGGTGAAGTGAT	0.682000			T	TLX3	T-ALL								3	4					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196682946	196682946	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:196682946C>T	ENST00000367429.4	+	10	1658	c.1418C>T	c.(1417-1419)gCg>gTg	p.A473V		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	473	Sushi 8.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						AAAGAAAAAGCGAAATATCAA	0.353000													11	23					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240003880	240003880	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:240003880T>C	ENST00000345617.3	-	21	3346	c.2555A>G	c.(2554-2556)tAc>tGc	p.Y852C	HDAC4_ENST00000543185.1_Missense_Mutation_p.Y436C	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	852	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GGGGTCGCTGTAGAAAGCCTG	0.587000													30	36					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	62994217	62994217	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:62994217G>A	ENST00000561311.1	+	17	1953	c.1723G>A	c.(1723-1725)Gct>Act	p.A575T	TLN2_ENST00000306829.6_Missense_Mutation_p.A575T			Q9Y4G6	TLN2_HUMAN	talin 2	575					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						TGACTACACAGCTGTGGGATG	0.532000													21	89					0	0	1	0	0
TNIP1	10318	broad.mit.edu	37	5	150439883	150439883	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150439883G>A	ENST00000389378.2	-	5	1019	c.431C>T	c.(430-432)gCg>gTg	p.A144V	TNIP1_ENST00000523338.1_Missense_Mutation_p.A144V|TNIP1_ENST00000520931.1_Missense_Mutation_p.A91V|TNIP1_ENST00000521591.1_Missense_Mutation_p.A144V|TNIP1_ENST00000524280.1_Missense_Mutation_p.A144V|TNIP1_ENST00000522226.1_Missense_Mutation_p.A144V|TNIP1_ENST00000518977.1_Missense_Mutation_p.A144V|TNIP1_ENST00000315050.7_Missense_Mutation_p.A144V|TNIP1_ENST00000523200.1_Missense_Mutation_p.A144V	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	144	Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACTCACCATCGCATTGGCATG	0.562000													11	23					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196285152	196285152	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:196285152C>A	ENST00000367433.5	-	20	2382	c.2281G>T	c.(2281-2283)Gat>Tat	p.D761Y	KCNT2_ENST00000294725.8_Missense_Mutation_p.D785Y|KCNT2_ENST00000367431.4_Missense_Mutation_p.D711Y|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Splice_Site			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	785						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						AGTAAGTCATCTAGGCTTTGA	0.388000													8	15					0.335167	0.335495	1	1	0
IFIT1B	439996	broad.mit.edu	37	10	91143820	91143820	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:91143820G>T	ENST00000371809.3	+	2	830	c.750G>T	c.(748-750)caG>caT	p.Q250H	LIPA_ENST00000371837.1_Intron	NM_001010987.2	NP_001010987.1	Q5T764	IFT1B_HUMAN	interferon-induced protein with tetratricopeptide repeats 1B	250							binding			endometrium(2)|large_intestine(3)|lung(8)	13						TATCTTCACAGGCCTATGTCT	0.423000													6	145					0.217242	0.217582	1	1	0
ENPP2	0	broad.mit.edu	37	8	120631537	120631537	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:120631537C>T	ENST00000427067.2	-	5	594	c.414G>A	c.(412-414)tcG>tcA	p.S138S	ENPP2_ENST00000259486.6_Silent_p.S142S|ENPP2_ENST00000522826.1_Silent_p.S142S|ENPP2_ENST00000075322.6_Silent_p.S142S			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	142	SMB 2.				cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CAACCCAATGCGACTCTCCTA	0.378000													25	48					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81745071	81745071	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:81745071G>A	ENST00000555447.1	-	6	996	c.584C>T	c.(583-585)tCg>tTg	p.S195L	STON2_ENST00000267540.2_Missense_Mutation_p.S195L|STON2_ENST00000556280.1_5'UTR	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	195					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TTCTTGAAGCGAGGAGGAATT	0.493000													6	51					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69957223	69957223	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:69957223G>A	ENST00000358913.5	+	16	3761	c.3273G>A	c.(3271-3273)cgG>cgA	p.R1091R	MYPN_ENST00000354393.2_Silent_p.R816R|MYPN_ENST00000540630.1_Silent_p.R1091R	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	1091	Ig-like 4.|Interaction with ACTN.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GCCTCTGTCGGCTGGACTGTA	0.458000													30	48					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57724940	57724940	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:57724940C>T	ENST00000269122.3	+	3	706	c.432C>T	c.(430-432)cgC>cgT	p.R144R	CLTC_ENST00000393043.1_Silent_p.R144R|CLTC_ENST00000579456.1_Intron	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	144	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TGTTTGATCGCCATTCTAGCC	0.413000			T	"""ALK, TFE3"""	"""ALCL, renal """								29	68					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13768515	13768515	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:13768515G>T	ENST00000279593.3	-	6	1621	c.1412C>A	c.(1411-1413)tCt>tAt	p.S471Y		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	471					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAACTTCACAGATTTAGAAAT	0.408000													32	134					4.62619e-21	5.13336e-21	1	1	0
SSPO	23145	broad.mit.edu	37	7	149500345	149500345	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149500345C>T	ENST00000378016.2	+	0	7871							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TATGTGAGTGCCGATCTGTGC	0.652000													4	6					0	0	1	0	0
STK17B	9262	broad.mit.edu	37	2	197004383	197004383	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:197004383G>A	ENST00000263955.4	-	7	1083	c.797C>T	c.(796-798)gCc>gTc	p.A266V	STK17B_ENST00000409228.1_Missense_Mutation_p.A266V	NM_004226.3	NP_004217.1	O94768	ST17B_HUMAN	serine/threonine kinase 17b	266	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(10)	15			OV - Ovarian serous cystadenocarcinoma(117;0.141)			AAAGTCTGTGGCCAGCTGTGA	0.284000													26	65					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18692021	18692021	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:18692021A>G	ENST00000251296.1	+	6	1228	c.845A>G	c.(844-846)gAg>gGg	p.E282G		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	282						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CACAGCGCCGAGCCCACCTAC	0.632000													22	30					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52521840	52521840	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52521840C>T	ENST00000345716.4	+	16	2466	c.2332C>T	c.(2332-2334)Ctg>Ttg	p.L778L	NISCH_ENST00000479054.1_Silent_p.L778L	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	778	Interaction with ITGA5 (By similarity).|Interaction with LIMK (By similarity).|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CATGCCGGAGCTGTGTCTGGT	0.602000													20	26					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24791325	24791325	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24791325C>T	ENST00000310677.4	-	21	2646	c.2533G>A	c.(2533-2535)Gtg>Atg	p.V845M	ADCY4_ENST00000418030.2_Missense_Mutation_p.V845M|ADCY4_ENST00000554068.2_Missense_Mutation_p.V845M	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	845					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		GCAGGGAGCACGTTCTCCAAG	0.612000													52	62					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154190896	154190896	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:154190896C>T	ENST00000336314.4	+	17	2726	c.2702C>T	c.(2701-2703)aCg>aTg	p.T901M		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	978							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CAGGAGGAAACGGTGAAGGAC	0.483000													23	33					0	0	1	0	0
CSDC2	27254	broad.mit.edu	37	22	41969707	41969707	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:41969707G>T	ENST00000306149.7	+	3	769	c.225G>T	c.(223-225)caG>caT	p.Q75H		NM_014460.3	NP_055275.1	Q9Y534	CSDC2_HUMAN	cold shock domain containing C2, RNA binding	75	CSD.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|RNA binding			prostate(2)|upper_aerodigestive_tract(1)	3						TCTGTAAGCAGTTCTCACGCT	0.612000													8	42					0.00307968	0.00311927	1	1	0
ARID4A	5926	broad.mit.edu	37	14	58790255	58790255	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:58790255C>T	ENST00000355431.3	+	8	875	c.502C>T	c.(502-504)Cgc>Tgc	p.R168C	ARID4A_ENST00000348476.3_Missense_Mutation_p.R168C|ARID4A_ENST00000431317.2_Missense_Mutation_p.R168C|ARID4A_ENST00000395168.3_Missense_Mutation_p.R168C	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	168					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TGAAGACAAGCGCCGTCTCAA	0.368000													33	29					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3263044	3263044	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:3263044T>C	ENST00000382004.3	-	14	1807	c.1496A>G	c.(1495-1497)tAc>tGc	p.Y499C	RFX3_ENST00000358730.2_Missense_Mutation_p.Y499C|RFX3_ENST00000302303.1_Missense_Mutation_p.Y499C	NM_134428.1	NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	499					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		AAGCGACGTGTATCTTCGCAG	0.498000													17	29					0	0	1	0	0
CDC25A	993	broad.mit.edu	37	3	48200940	48200940	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48200940C>T	ENST00000302506.3	-	14	1736	c.1328G>A	c.(1327-1329)cGg>cAg	p.R443Q	CDC25A_ENST00000351231.3_Missense_Mutation_p.R403Q	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	443	Rhodanese.				cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		TCTCACATACCGGCACCTAGT	0.512000													21	30					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49244260	49244260	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49244260C>T	ENST00000332955.2	-	10	1505	c.958G>A	c.(958-960)Gat>Aat	p.D320N		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	320					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TTGATGAAATCGATCACCTTC	0.517000													27	32					0	0	1	0	0
IFIT3	3437	broad.mit.edu	37	10	91099418	91099418	+	Missense_Mutation	SNP	G	G	A	rs151167903		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:91099418G>A	ENST00000371818.4	+	2	1186	c.1006G>A	c.(1006-1008)Gct>Act	p.A336T	LIPA_ENST00000371837.1_Intron|IFIT3_ENST00000371811.4_Missense_Mutation_p.A336T|LIPA_ENST00000487618.1_Intron	NM_001549.4	NP_001540.2	O14879	IFIT3_HUMAN	interferon-induced protein with tetratricopeptide repeats 3	336					type I interferon-mediated signaling pathway		protein binding			breast(1)|central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)|urinary_tract(1)	15						CTCCGATCTCGCTGAGTTCCT	0.423000													39	62					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67431903	67431903	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67431903C>T	ENST00000349015.3	-	8	1275	c.837G>A	c.(835-837)aaG>aaA	p.K279K	ALDH3B2_ENST00000530069.1_Silent_p.K279K	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	279					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	GGGCCAGGGGCTTCTCCTGCC	0.642000													32	46					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72958763	72958763	+	Silent	SNP	C	C	T	rs145960717	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:72958763C>T	ENST00000262209.4	-	17	2253	c.2046G>A	c.(2044-2046)ccG>ccA	p.P682P	RP11-383H13.1_ENST00000524152.1_Intron|RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000457356.4_Intron	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	682						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	GGGCTGTAAGCGGTTCATATA	0.279000													7	60					0	0	1	0	0
HCG17	0	broad.mit.edu	37	6	30228211	30228211	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30228211G>A	ENST00000453558.1	-	0	126				HLA-L_ENST00000463348.1_RNA																							GGATTACATCGCCCTGAACGA	0.607000													20	19					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17418790	17418790	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:17418790C>T	ENST00000302539.4	-	32	4066	c.3941G>A	c.(3940-3942)cGc>cAc	p.R1314H	ABCC8_ENST00000389817.3_Missense_Mutation_p.R1313H	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1313					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CCCATGGATGCGCTTCACAGC	0.617000													18	40					0	0	1	0	0
SLC6A16	28968	broad.mit.edu	37	19	49793460	49793460	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49793460G>A	ENST00000335875.4	-	12	2372	c.2131C>T	c.(2131-2133)Ccc>Tcc	p.P711S	SLC6A16_ENST00000454748.3_3'UTR	NM_014037.2	NP_054756.2	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	711						integral to membrane|intracellular	neurotransmitter:sodium symporter activity			NS(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		TCTTTACTGGGTGTTAGCTGG	0.448000													47	74					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	47991512	47991512	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:47991512G>T	ENST00000371741.4	-	2	751	c.585C>A	c.(583-585)tcC>tcA	p.S195S		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	195					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGAACATGATGGAAATTATGG	0.517000													10	12					1.08611e-07	1.14056e-07	1	1	0
TMC3	342125	broad.mit.edu	37	15	81625594	81625594	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:81625594G>A	ENST00000558726.1	-	22	2607	c.2472C>T	c.(2470-2472)caC>caT	p.H824H	RP11-761I4.3_ENST00000559781.1_RNA|RP11-761I4.3_ENST00000560851.1_RNA|TMC3_ENST00000359440.5_Silent_p.H823H|RP11-761I4.3_ENST00000560973.1_RNA			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	823						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						CACACAGACCGTGCAGATACC	0.527000													17	20					0	0	1	0	0
NR3C2	0	broad.mit.edu	37	4	149356823	149356823	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:149356823T>C	ENST00000355292.3	-	2	1552	c.1190A>G	c.(1189-1191)tAc>tGc	p.Y397C	NR3C2_ENST00000511528.1_Missense_Mutation_p.Y397C|NR3C2_ENST00000344721.4_Missense_Mutation_p.Y397C|NR3C2_ENST00000512865.1_Missense_Mutation_p.Y397C|NR3C2_ENST00000358102.3_Missense_Mutation_p.Y397C|NR3C2_ENST00000342437.4_Missense_Mutation_p.Y397C			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	397	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TGGTTTTATGTACTGGACAAT	0.423000													30	50					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152718015	152718015	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152718015C>T	ENST00000367255.5	-	50	8052	c.7451G>A	c.(7450-7452)aGc>aAc	p.S2484N	SYNE1_ENST00000448038.1_Missense_Mutation_p.S2491N|SYNE1_ENST00000341594.5_Missense_Mutation_p.S2523N|SYNE1_ENST00000423061.1_Missense_Mutation_p.S2491N|SYNE1_ENST00000265368.4_Missense_Mutation_p.S2484N	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2484					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCTTGAATGCTACTGACAAT	0.388000										HNSCC(10;0.0054)			18	105					0	0	1	0	0
FH	2271	broad.mit.edu	37	1	241665775	241665775	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:241665775G>A	ENST00000366560.3	-	8	1242	c.1204C>T	c.(1204-1206)Cat>Tat	p.H402Y		NM_000143.3	NP_000134.2	P07954	FUMH_HUMAN	fumarate hydratase	402					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(2)	26	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		AACTCAAAATGTCCATTGCTG	0.403000			"""Mis, N, F"""			"""lieomyomatosis, renal"""			Hereditary Leiomyomatosis and Renal Cell Cancer				17	43					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166844001	166844001	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:166844001G>A	ENST00000510118.1	-	18	1936	c.1596C>T	c.(1594-1596)cgC>cgT	p.R532R	RPS6KA2_ENST00000481261.2_Silent_p.R418R|RPS6KA2_ENST00000405189.3_Silent_p.R418R|RPS6KA2_ENST00000503859.1_Silent_p.R515R|RPS6KA2_ENST00000265678.4_Silent_p.R507R			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	507	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		CACTGGCTTCGCGCTCCGAGA	0.597000													5	46					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27121448	27121448	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27121448C>T	ENST00000288699.6	+	2	239	c.81C>T	c.(79-81)gaC>gaT	p.D27D	DPYSL5_ENST00000401478.1_Silent_p.D27D	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	27					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACGAGGCTGACGTCTACATCG	0.572000													4	80					0	0	1	0	0
MTMR2	8898	broad.mit.edu	37	11	95598776	95598776	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:95598776A>G	ENST00000393223.3	-	5	697	c.35T>C	c.(34-36)aTt>aCt	p.I12T	MTMR2_ENST00000346299.5_Missense_Mutation_p.I84T|MTMR2_ENST00000409459.1_Missense_Mutation_p.I12T|MTMR2_ENST00000484818.1_5'UTR|MTMR2_ENST00000352297.7_Missense_Mutation_p.I12T	NM_001243571.1|NM_201278.2	NP_001230500.1|NP_958435.1	Q13614	MTMR2_HUMAN	myotubularin related protein 2	84	Ser-rich.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	19		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CATGTCTTTAATATTTTCTCC	0.403000													41	52					0	0	1	0	0
KIAA0355	9710	broad.mit.edu	37	19	34818985	34818985	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:34818985C>T	ENST00000299505.6	+	6	1906	c.1033C>T	c.(1033-1035)Cag>Tag	p.Q345*		NM_014686.3	NP_055501.2	O15063	K0355_HUMAN	KIAA0355	345										breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					CGTCCCTGTGCAGATAGGATC	0.602000													31	41					0	0	1	0	0
RNF186	54546	broad.mit.edu	37	1	20141347	20141347	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:20141347G>A	ENST00000375121.2	-	1	424	c.248C>T	c.(247-249)cCg>cTg	p.P83L	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	83						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCGGCACAGCGGGCAGGTGAT	0.682000													21	29					0	0	1	0	0
CD247	919	broad.mit.edu	37	1	167410003	167410003	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:167410003C>A	ENST00000392122.3	-	2	204	c.58_splice	c.e2-1	p.E20_splice	CD247_ENST00000362089.5_Splice_Site_p.E20_splice|CD247_ENST00000483825.1_5'UTR	NM_000734.3|NM_198053.2	NP_000725.1|NP_932170.1	P20963	CD3Z_HUMAN	CD247 molecule	20					interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(543;0.236)			AGCTCTGTGCCTCTGTGCCAA	0.517000													8	4					0.000274275	0.000279654	1	1	0
SLC26A2	1836	broad.mit.edu	37	5	149360642	149360642	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149360642C>T	ENST00000286298.4	+	3	1754	c.1486C>T	c.(1486-1488)Cgt>Tgt	p.R496C		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	496						integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GGGAGCCCTTCGTAAATTTAG	0.398000													39	55					0	0	1	0	0
NPY1R	0	broad.mit.edu	37	4	164247095	164247095	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:164247095C>T	ENST00000296533.2	-	2	1143	c.612G>A	c.(610-612)tcG>tcA	p.S204S	NPY1R_ENST00000509586.1_Intron	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	204					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TATGAGAGTCCGATGGAAATT	0.383000													6	25					0	0	1	0	0
WDR35	57539	broad.mit.edu	37	2	20135319	20135319	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:20135319G>A	ENST00000345530.3	-	22	2608	c.2493C>T	c.(2491-2493)cgC>cgT	p.R831R	WDR35_ENST00000416055.2_Silent_p.R396R|WDR35_ENST00000281405.4_Silent_p.R820R	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	831										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATTCAGCTAAGCGTTCCTGGT	0.353000													24	33					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5862948	5862948	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5862948G>T	ENST00000329322.5	-	1	179	c.180C>A	c.(178-180)ccC>ccA	p.P60P	OR52E6_ENST00000379946.2_Silent_p.P64P|TRIM5_ENST00000380027.1_Intron	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	60					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGTAGTACATGGGCTCATGGA	0.458000													26	45					7.26314e-15	7.9373e-15	1	1	0
CBWD2	150472	broad.mit.edu	37	2	114195456	114195456	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:114195456C>G	ENST00000259199.4	+	1	189	c.11C>G	c.(10-12)gCt>gGt	p.A4G	CBWD2_ENST00000433343.2_5'UTR|CBWD2_ENST00000416503.2_Missense_Mutation_p.A4G	NM_172003.3	NP_742000.1	Q8IUF1	CBWD2_HUMAN	COBW domain containing 2	4							ATP binding|protein binding			endometrium(1)|lung(1)	2						ATGTTACCGGCTGTTGGATCT	0.627000													34	44					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60062070	60062070	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:60062070G>A	ENST00000397786.2	-	14	2709	c.2633C>T	c.(2632-2634)gCg>gTg	p.A878V		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	878					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTTGAACTGCGCTCCTATACT	0.338000													18	52					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21467132	21467132	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:21467132C>T	ENST00000281523.2	-	6	1222	c.704G>A	c.(703-705)cGg>cAg	p.R235Q		NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	235						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						ACTTCCATTCCGGGCTTCTAA	0.453000													14	30					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769303	247769303	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247769303G>A	ENST00000320002.2	+	1	448	c.416G>A	c.(415-417)cGg>cAg	p.R139Q	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATGAACCCACGGCTTTGCCAA	0.507000													49	69					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35546639	35546639	+	Silent	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35546639A>C	ENST00000455600.1	+	2	690	c.121A>C	c.(121-123)Aga>Cga	p.R41R	RUSC2_ENST00000468041.1_3'UTR	NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	41						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			TGGGAGCACAAGACCTAATCC	0.597000													12	25					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22939742	22939742	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:22939742A>G	ENST00000397104.3	-	6	2588	c.2590_splice	c.e6+1	p.C863_splice						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAGCTTTACCACATTCTTCAC	0.353000													22	37					0	0	1	0	0
GJA4	2701	broad.mit.edu	37	1	35260208	35260208	+	Missense_Mutation	SNP	C	C	T	rs61777220	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:35260208C>T	ENST00000342280.4	+	2	482	c.394C>T	c.(394-396)Cgt>Tgt	p.R132C		NM_002060.2	NP_002051.2	P35212	CXA4_HUMAN	gap junction protein, alpha 4, 37kDa	132					cell-cell junction assembly	integral to plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(4)|stomach(1)	14		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				GGCCGTAGAGCGTCAGATGGC	0.667000													10	15					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20006632	20006632	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:20006632G>A	ENST00000400230.2	-	16	1247	c.1203C>T	c.(1201-1203)ttC>ttT	p.F401F	TPTE2_ENST00000255310.6_Silent_p.F324F|TPTE2_ENST00000382978.1_Silent_p.F361F|TPTE2_ENST00000382975.4_Silent_p.F361F|TPTE2_ENST00000457266.2_Silent_p.F290F|TPTE2_ENST00000400103.2_Silent_p.F290F|TPTE2_ENST00000390680.2_Silent_p.F324F|TPTE2_ENST00000382977.4_Silent_p.F401F			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	401	C2 tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		AATAAATAATGAATCTTTTTA	0.393000													9	27					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43018788	43018788	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43018788C>T	ENST00000535468.1	-	4	1489	c.1403G>A	c.(1402-1404)cGg>cAg	p.R468Q	CUL7_ENST00000265348.3_Missense_Mutation_p.R384Q	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	384					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			ATCCAGCATCCGCACTCGCAT	0.567000													25	37					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184295154	184295154	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:184295154C>T	ENST00000330394.2	+	6	1830	c.1378C>T	c.(1378-1380)Cgc>Tgc	p.R460C	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	460	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCCCACACTACGCCTGCACAG	0.622000													13	26					0	0	1	0	0
PSMD11	5717	broad.mit.edu	37	17	30800864	30800864	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:30800864C>T	ENST00000261712.3	+	7	952	c.689C>T	c.(688-690)tCa>tTa	p.S230L	PSMD11_ENST00000457654.2_Missense_Mutation_p.S230L	NM_001270482.1|NM_002815.3	NP_001257411.1|NP_002806.2	O00231	PSD11_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	230	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding	p.S230L(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			ACTGCGTACTCATACTTCTAT	0.413000													34	58					0	0	1	0	0
ARHGEF26	26084	broad.mit.edu	37	3	153840055	153840055	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:153840055G>A	ENST00000356448.4	+	2	558	c.274G>A	c.(274-276)Gcc>Acc	p.A92T	ARHGEF26_ENST00000465817.1_Missense_Mutation_p.A92T|ARHGEF26_ENST00000465093.1_Missense_Mutation_p.A92T	NM_001251962.1	NP_001238891.1	Q96DR7	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 26	92					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	23						GAGAGCGGTGGCCAATGGTGG	0.697000													8	8					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144060434	144060434	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:144060434C>A	ENST00000056217.5	+	2	846	c.672C>A	c.(670-672)ccC>ccA	p.P224P		NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	224					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					TCTTGCATCCCCAGGAGGTCC	0.572000													47	180					3.56336e-21	3.95573e-21	1	1	0
NBPF1	55672	broad.mit.edu	37	1	16895689	16895689	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16895689G>A	ENST00000430580.2	-	23	3380	c.2493C>T	c.(2491-2493)tcC>tcT	p.S831S	NBPF1_ENST00000420031.2_3'UTR|NBPF1_ENST00000287968.8_3'UTR|NBPF1_ENST00000432949.1_Intron	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	831	NBPF 4.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CTTCATCCCAGGACTCCTGGG	0.478000													30	247					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179413764	179413764	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179413764G>A	ENST00000589042.1	-	339	92813	c.92589C>T	c.(92587-92589)gcC>gcT	p.A30863A	TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Silent_p.A21990A|TTN_ENST00000591111.1_Silent_p.A29222A|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Silent_p.A21798A|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Silent_p.A28295A|TTN_ENST00000359218.5_Silent_p.A21923A|RP11-65L3.2_ENST00000603415.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29222	Fibronectin type-III 125.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCTAAGTCGGCCTTACACA	0.403000													25	31					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63488557	63488557	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:63488557C>T	ENST00000374852.3	-	14	2042	c.1975G>A	c.(1975-1977)Gac>Aac	p.D659N	MTMR8_ENST00000453546.1_Intron	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	659						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						TCAGAGATGTCCATGGCCCCA	0.557000													20	21					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38397186	38397186	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:38397186C>T	ENST00000377698.3	+	2	1594	c.1441C>T	c.(1441-1443)Cca>Tca	p.P481S		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	481					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	CTGCCACACGCCATTTGGAGG	0.557000													7	24					0	0	1	0	0
GCM1	8521	broad.mit.edu	37	6	52993189	52993189	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:52993189C>T	ENST00000259803.7	-	6	1337	c.1126G>A	c.(1126-1128)Gtc>Atc	p.V376I		NM_003643.3	NP_003634.2	Q9NP62	GCM1_HUMAN	glial cells missing homolog 1 (Drosophila)	376						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1)	24	Lung NSC(77;0.0755)					GGAGACTGGACGTAGCTGTTA	0.478000													5	127					0	0	1	0	0
ABHD11	83451	broad.mit.edu	37	7	73151925	73151925	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:73151925T>C	ENST00000222800.3	-	3	498	c.429A>G	c.(427-429)ggA>ggG	p.G143G	ABHD11_ENST00000437775.2_Silent_p.G136G|ABHD11_ENST00000458339.1_Silent_p.G143G|ABHD11_ENST00000395147.4_Silent_p.G143G	NM_148912.2	NP_683710.1	Q8NFV4	ABHDB_HUMAN	abhydrolase domain containing 11	143							hydrolase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Lung NSC(55;0.0908)|all_lung(88;0.198)				CTGTCTTTCCTCCCATGCTGT	0.622000													5	14					0	0	1	0	0
CABP4	57010	broad.mit.edu	37	11	67223812	67223812	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67223812G>A	ENST00000438189.2	+	4	469	c.125G>A	c.(124-126)gGc>gAc	p.G42D	CABP4_ENST00000325656.5_Missense_Mutation_p.G147D			P57796	CABP4_HUMAN	calcium binding protein 4	147					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding			central_nervous_system(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(2)	11			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GACCGTGACGGCTACATCAGC	0.642000													21	24					0	0	1	0	0
RPGR	6103	broad.mit.edu	37	X	38178228	38178228	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:38178228A>G	ENST00000378505.2	-	5	499	c.323T>C	c.(322-324)gTa>gCa	p.V108A	RPGR_ENST00000309513.3_Missense_Mutation_p.V108A|RPGR_ENST00000342811.3_Missense_Mutation_p.V108A|RPGR_ENST00000339363.3_Missense_Mutation_p.V108A|TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000338898.3_Missense_Mutation_p.V108A|RPGR_ENST00000318842.7_Missense_Mutation_p.V108A	NM_001034853.1	NP_001030025.1	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	108					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						AGTTGCATATACATTGCCTCC	0.398000													33	8					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7673019	7673019	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7673019C>T	ENST00000299492.4	+	23	2768	c.2380C>T	c.(2380-2382)Cga>Tga	p.R794*	PPFIBP2_ENST00000530181.1_Nonsense_Mutation_p.R651*|PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000533792.1_Nonsense_Mutation_p.R636*|PPFIBP2_ENST00000528883.1_Nonsense_Mutation_p.R682*	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	794					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		ACAGGAGAAGCGAGAGAAAAT	0.582000													31	30					0	0	1	0	0
PSKH1	5681	broad.mit.edu	37	16	67943086	67943086	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67943086G>A	ENST00000291041.5	+	2	604	c.434G>A	c.(433-435)cGt>cAt	p.R145H		NM_006742.2	NP_006733.1	P11801	KPSH1_HUMAN	protein serine kinase H1	145	Protein kinase.					endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|nuclear speck|plasma membrane	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(7)|pancreas(1)	12		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0044)|Epithelial(162;0.0197)|all cancers(182;0.128)		TCGGAGCTGCGTGTGCTGCGT	0.612000													14	24					0	0	1	0	0
CEACAM6	4680	broad.mit.edu	37	19	42260867	42260867	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42260867C>T	ENST00000199764.6	+	2	642	c.424_splice	c.e2+1	p.P142_splice	CEA_ENST00000598976.1_Intron	NM_002483.4	NP_002474.3	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	142	Ig-like V-type.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane		p.P142S(1)		breast(1)|kidney(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		CCATGTATACCGTGAGTATTT	0.488000													5	204					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40661215	40661215	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:40661215A>G	ENST00000454349.2	+	5	1192	c.981A>G	c.(979-981)acA>acG	p.T327T	TNRC6B_ENST00000402203.1_Intron|TNRC6B_ENST00000301923.9_Intron|TNRC6B_ENST00000335727.8_Silent_p.T327T	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	327					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						CATTGGAAACAGATAATAGTA	0.473000													18	22					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26872461	26872461	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26872461C>T	ENST00000531382.1	+	1	119	c.70C>T	c.(70-72)Cgg>Tgg	p.R24W	RPS6KA1_ENST00000526792.1_Intron|RPS6KA1_ENST00000374162.2_Intron|RPS6KA1_ENST00000374166.4_Intron|RPS6KA1_ENST00000374168.2_Intron|RPS6KA1_ENST00000530003.1_Intron	NM_001006665.1	NP_001006666.1	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	19					axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		CAGGAAGCAGCGGCCCAGGAT	0.697000													3	7					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204001353	204001353	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:204001353C>G	ENST00000449802.1	+	28	4667	c.4334C>G	c.(4333-4335)aCa>aGa	p.T1445R		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	1445							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CAATTACTGACACATATTTTG	0.343000													15	22					0	0	1	0	0
ADRA2C	152	broad.mit.edu	37	4	3768676	3768676	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:3768676G>A	ENST00000330055.5	+	1	552	c.343G>A	c.(343-345)Gcc>Acc	p.A115T	ADRA2C_ENST00000509482.1_Missense_Mutation_p.A115T	NM_000683.3	NP_000674.2	P18825	ADA2C_HUMAN	adrenoceptor alpha 2C	115					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CGAGCTCATGGCCTACTGGTA	0.632000													5	26					0	0	1	0	0
MXD3	83463	broad.mit.edu	37	5	176734710	176734710	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176734710C>T	ENST00000423571.2	-	5	641	c.577G>A	c.(577-579)Gcg>Acg	p.A193T	MXD3_ENST00000427908.2_Intron|MXD3_ENST00000513063.1_Intron|MXD3_ENST00000439742.2_Intron			Q9BW11	MAD3_HUMAN	MAX dimerization protein 3	193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding					all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCCTCTGCGCGGGGAGGGGT	0.682000													15	15					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190561072	190561072	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190561072G>T	ENST00000520309.1	+	7	1773	c.1685G>T	c.(1684-1686)aGg>aTg	p.R562M	ANKAR_ENST00000438402.2_Missense_Mutation_p.R562M|ANKAR_ENST00000281412.6_Missense_Mutation_p.R326M|ANKAR_ENST00000431575.2_Missense_Mutation_p.R491M|ANKAR_ENST00000313581.4_Missense_Mutation_p.R562M	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	562						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			GTCAACCAGAGGCGCTTTGTT	0.368000													31	59					2.09667e-21	2.32829e-21	1	1	0
OAS3	4940	broad.mit.edu	37	12	113407445	113407445	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:113407445G>A	ENST00000228928.7	+	15	3316	c.3137G>A	c.(3136-3138)gGc>gAc	p.G1046D	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	1046	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						GACCCGACAGGCAACCTGGGC	0.607000													5	8					0	0	1	0	0
OR1A2	26189	broad.mit.edu	37	17	3101147	3101147	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3101147G>A	ENST00000381951.1	+	1	335	c.335G>A	c.(334-336)aGc>aAc	p.S112N		NM_012352.1	NP_036484.1	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A, member 2	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(4)|stomach(2)	18						AAGGCAGACAGCTATACCTTG	0.493000													13	50					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375667	113375667	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:113375667A>G	ENST00000316407.4	-	7	5272	c.4862T>C	c.(4861-4863)gTa>gCa	p.V1621A	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.V1621A	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1621					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						ATGGCCAGATACATGTTCAGA	0.448000													20	25					0	0	1	0	0
RPL29	6159	broad.mit.edu	37	3	52028115	52028115	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52028115G>A	ENST00000466397.1	-	4	270	c.130C>T	c.(130-132)Cgc>Tgc	p.R44C	RPL29_ENST00000475248.1_Missense_Mutation_p.R44C|RPL29_ENST00000479017.1_Missense_Mutation_p.R44C|RPL29_ENST00000495383.1_Missense_Mutation_p.R44C|RPL29_ENST00000294189.6_Missense_Mutation_p.R44C			P47914	RL29_HUMAN	ribosomal protein L29	44					embryo implantation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|protein binding|RNA binding|structural constituent of ribosome			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TTGGCAAAGCGCATGTTCCTC	0.552000													6	22					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37462223	37462223	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37462223G>A	ENST00000381792.2	-	19	2512	c.2372C>T	c.(2371-2373)gCg>gTg	p.A791V	TMPRSS6_ENST00000346753.3_Missense_Mutation_p.A778V|TMPRSS6_ENST00000406725.1_Missense_Mutation_p.A769V|TMPRSS6_ENST00000406856.1_Missense_Mutation_p.A791V			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	778	Peptidase S1.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						GACCAGCCCCGCCAGGAACCA	0.627000													12	11					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145107481	145107481	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145107481G>A	ENST00000426825.1	-	23	3255	c.3174C>T	c.(3172-3174)cgC>cgT	p.R1058R	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1058							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GAATGACCACGCGCACTGGCG	0.731000													7	9					0	0	1	0	0
ZNF572	137209	broad.mit.edu	37	8	125988871	125988871	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:125988871G>A	ENST00000319286.5	+	3	515	c.361G>A	c.(361-363)Gtc>Atc	p.V121I		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CAATGCCTGTGTCCAGCAGAA	0.433000										HNSCC(60;0.17)			29	27					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156845889	156845889	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156845889C>T	ENST00000368196.3	+	12	1621	c.1501C>T	c.(1501-1503)Cgc>Tgc	p.R501C	NTRK1_ENST00000392302.2_Missense_Mutation_p.R471C|NTRK1_ENST00000358660.3_Missense_Mutation_p.R504C|NTRK1_ENST00000524377.1_Missense_Mutation_p.R507C	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	507					activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CCACATCAAGCGCCGGGACAT	0.627000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			19	44					0	0	1	0	0
PPM1K	152926	broad.mit.edu	37	4	89199518	89199518	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:89199518T>C	ENST00000295908.6	-	2	607	c.218A>G	c.(217-219)gAg>gGg	p.E73G	PPM1K_ENST00000513546.2_5'UTR|PPM1K_ENST00000506423.1_Missense_Mutation_p.E73G|PPM1K_ENST00000315194.4_Missense_Mutation_p.E73G	NM_152542.3	NP_689755.3	Q8N3J5	PPM1K_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1K	73					protein dephosphorylation	mitochondrial matrix|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	13		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000192)		CAGAATTGGCTCATCAATGCG	0.507000													10	21					0	0	1	0	0
IGHV2-5	0	broad.mit.edu	37	14	106494574	106494574	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:106494574C>T	ENST00000390597.2	-	0	23																											CAAAGTGTGTCCATGGTGGGG	0.552000													10	12					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17918795	17918795	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17918795C>T	ENST00000318683.6	+	2	326	c.179C>T	c.(178-180)cCg>cTg	p.P60L	B3GNT3_ENST00000595387.1_Missense_Mutation_p.P60L	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	60					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						GCCCCGGCCCCGTGCCATGCC	0.677000													8	5					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50832039	50832039	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:50832039G>A	ENST00000442544.2	+	13	2619	c.2003G>A	c.(2002-2004)aGg>aAg	p.R668K	DCC_ENST00000412726.1_Missense_Mutation_p.R516K|DCC_ENST00000581580.1_Missense_Mutation_p.R323K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	668	Fibronectin type-III 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ACGACCCGCAGGGGTGAGATG	0.433000													19	76					0	0	1	0	0
ZNRF3	84133	broad.mit.edu	37	22	29444421	29444421	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:29444421C>T	ENST00000544604.2	+	7	1132	c.957C>T	c.(955-957)tgC>tgT	p.C319C	ZNRF3_ENST00000406323.3_Silent_p.C219C|ZNRF3_ENST00000402174.1_Silent_p.C219C|ZNRF3_ENST00000332811.4_Silent_p.C219C	NM_001206998.1	NP_001193927.1	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	319						integral to membrane	zinc ion binding	p.C219C(1)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(4)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	28						ACAGGAAGTGCGTGGACCCCT	0.607000													8	15					0	0	1	0	0
FGF20	26281	broad.mit.edu	37	8	16850729	16850729	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:16850729C>T	ENST00000180166.5	-	3	636	c.488G>A	c.(487-489)cGc>cAc	p.R163H		NM_019851.2	NP_062825.1	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	163					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	11				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		AAAATACCTGCGGCCAGTGTC	0.428000													8	160					0	0	1	0	0
KRT13	3860	broad.mit.edu	37	17	39661783	39661783	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39661783C>T	ENST00000246635.3	-	1	66	c.20G>A	c.(19-21)aGc>aAc	p.S7N	KRT13_ENST00000587544.1_Missense_Mutation_p.S7N|KRT13_ENST00000336861.3_Missense_Mutation_p.S7N	NM_153490.2	NP_705694.2	P13646	K1C13_HUMAN	keratin 13	7	Head.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				GGCAGAGGAGCTCTGCAGGCG	0.612000													13	25					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150444609	150444609	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:150444609G>A	ENST00000401000.4	+	10	3172	c.3107G>A	c.(3106-3108)cGc>cAc	p.R1036H	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.R1062H			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	1062							protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						GAGCACTACCGCATAGAAACC	0.532000													25	49					0	0	1	0	0
WFS1	7466	broad.mit.edu	37	4	6302972	6302972	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:6302972C>T	ENST00000226760.1	+	8	1620	c.1450C>T	c.(1450-1452)Ctt>Ttt	p.L484F	WFS1_ENST00000503569.1_Missense_Mutation_p.L484F	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	484					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		CCTGAAGGTCCTTGGCCAGAC	0.632000													25	26					0	0	1	0	0
C3orf67	200844	broad.mit.edu	37	3	58849269	58849269	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58849269T>C	ENST00000472469.1	-	11	1792	c.954A>G	c.(952-954)atA>atG	p.I318M	C3orf67_ENST00000295966.7_Intron|C3orf67_ENST00000482387.1_Intron|RP11-147N17.1_ENST00000482372.1_RNA|RP11-147N17.1_ENST00000463703.1_RNA|RP11-147N17.1_ENST00000492031.1_RNA|RP11-147N17.1_ENST00000493123.1_RNA			Q6ZVT6	CC067_HUMAN	chromosome 3 open reading frame 67	0										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(3)|prostate(2)|skin(1)	19		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		CTACTTCACTTATCAAGCAGT	0.393000													7	15					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50547193	50547193	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50547193C>T	ENST00000262794.5	+	5	746	c.663C>T	c.(661-663)gaC>gaT	p.D221D	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Silent_p.D221D|MOV10L1_ENST00000545383.1_Silent_p.D221D|MOV10L1_ENST00000540615.1_Silent_p.D201D	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	221					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GGAGAGGTGACGTGGTCAATG	0.517000													26	52					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70791091	70791091	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:70791091C>T	ENST00000358731.4	+	12	1918	c.1655C>T	c.(1654-1656)gCc>gTc	p.A552V	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	552					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CAACAAGATGCCACATCAGTA	0.303000													17	41					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117282877	117282877	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:117282877G>A	ENST00000278935.3	+	33	4523	c.4376G>A	c.(4375-4377)cGc>cAc	p.R1459H	CEP164_ENST00000533706.1_3'UTR	NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1459					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		AAGGTGTATCGCTTCTGAGGC	0.582000													5	34					0	0	1	0	0
GDPD5	81544	broad.mit.edu	37	11	75155510	75155510	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:75155510G>A	ENST00000526177.1	-	6	2209	c.331C>T	c.(331-333)Cgg>Tgg	p.R111W	GDPD5_ENST00000533805.1_Missense_Mutation_p.R4W|GDPD5_ENST00000336898.3_Missense_Mutation_p.R249W|GDPD5_ENST00000376282.3_Missense_Mutation_p.R130W|GDPD5_ENST00000443276.2_3'UTR|GDPD5_ENST00000529721.1_Missense_Mutation_p.R249W|GDPD5_ENST00000533784.1_Missense_Mutation_p.R130W			Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain containing 5	249					glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|skin(2)	20						AGGGCCTTCCGGAAGGACATG	0.582000													23	42					0	0	1	0	0
AKR7A2	8574	broad.mit.edu	37	1	19632609	19632609	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:19632609G>A	ENST00000235835.3	-	6	842	c.821C>T	c.(820-822)gCg>gTg	p.A274V		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	274					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCACCAACGCAATGGCCTC	0.617000													6	35					0	0	1	0	0
NDUFAF1	51103	broad.mit.edu	37	15	41687179	41687179	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:41687179G>A	ENST00000260361.4	-	3	1018	c.637C>T	c.(637-639)Cgt>Tgt	p.R213C		NM_016013.3	NP_057097.2	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1	213					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	12		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		CCATCCCCACGTACACGGAGA	0.453000													14	21					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133920513	133920513	+	Silent	SNP	C	C	T	rs143023529		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:133920513C>T	ENST00000220616.4	+	18	3970	c.3930C>T	c.(3928-3930)taC>taT	p.Y1310Y	TG_ENST00000377869.1_Silent_p.Y1310Y	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1310					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTGCTGACTACGCGGATTTGC	0.597000													20	37					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65628161	65628161	+	Silent	SNP	C	C	T	rs149026166	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:65628161C>T	ENST00000327987.4	-	3	794	c.543G>A	c.(541-543)acG>acA	p.T181T		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	181	Ig-like C2-type 2.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TCTCATTGTCCGTGTCAATTG	0.597000													34	57					0	0	1	0	0
DHX15	1665	broad.mit.edu	37	4	24578054	24578054	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:24578054C>A	ENST00000336812.4	-	2	475	c.319G>T	c.(319-321)Ggt>Tgt	p.G107C		NM_001358.2	NP_001349.2	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 15	107					mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	30		Breast(46;0.0503)				GACGTGTGACCTGCATGTCCG	0.458000													38	60					1.30015e-28	1.45562e-28	1	1	0
MPPED1	758	broad.mit.edu	37	22	43821208	43821208	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:43821208G>A	ENST00000417669.1	+	2	661	c.217G>A	c.(217-219)Gtg>Atg	p.V73M	MPPED1_ENST00000443721.1_Missense_Mutation_p.V73M|MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000538182.1_Missense_Mutation_p.V106M|MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000542779.1_Missense_Mutation_p.V73M			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	73							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				GCCACCGCATGTGCAGATGTA	0.657000													3	30					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84628868	84628868	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:84628868C>A	ENST00000284136.6	-	17	2265	c.2222G>T	c.(2221-2223)aGa>aTa	p.R741I	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	741	Arg/Lys-rich (basic).				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						GTTTCTCTGTCTCCGCTTCTC	0.502000													8	62					0.000157383	0.000161063	1	1	0
HOGA1	112817	broad.mit.edu	37	10	99359467	99359467	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99359467C>A	ENST00000370646.4	+	4	860	c.499C>A	c.(499-501)Ctg>Atg	p.L167M	HOGA1_ENST00000370647.4_Intron|PI4K2A_ENST00000370649.3_Intron|PI4K2A_ENST00000555577.1_Intron	NM_138413.3	NP_612422.2			4-hydroxy-2-oxoglutarate aldolase 1											breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|stomach(1)	14						CCCTGTGGTGCTGTACAGTGT	0.617000													9	106					0.000274275	0.000279654	1	1	0
SLC2A5	6518	broad.mit.edu	37	1	9118306	9118306	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:9118306G>T	ENST00000377424.4	-	2	216	c.37C>A	c.(37-39)Ctg>Atg	p.L13M	SLC2A5_ENST00000377414.3_Missense_Mutation_p.L13M|SLC2A5_ENST00000535586.1_Intron	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	13					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		ACAAGCGTCAGCCTCTGCAGA	0.552000													12	16					2.80697e-09	2.97546e-09	1	1	0
IGKV5-2	0	broad.mit.edu	37	2	89197299	89197299	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:89197299C>T	ENST00000390244.2	+	0	407																											GATAATTTCCCTCTCACAGTG	0.438000													16	15					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73617515	73617515	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:73617515G>A	ENST00000261917.3	-	6	2752	c.1759C>T	c.(1759-1761)Cgg>Tgg	p.R587W		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	587					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		ACCAGCTTCCGACAGTTAAAG	0.607000													28	45					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99467887	99467887	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:99467887C>A	ENST00000268035.6	+	13	3367	c.2756C>A	c.(2755-2757)cCt>cAt	p.P919H	IGF1R_ENST00000558762.1_Missense_Mutation_p.P919H	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	919	Fibronectin type-III 3.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TGGACAGATCCTGTGTTCTTC	0.542000													25	31					5.45024e-15	5.96122e-15	1	1	0
MLST8	64223	broad.mit.edu	37	16	2257059	2257059	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2257059G>A	ENST00000569417.1	+	5	722	c.368G>A	c.(367-369)cGg>cAg	p.R123Q	MLST8_ENST00000397124.1_Missense_Mutation_p.R123Q|MLST8_ENST00000564088.1_Missense_Mutation_p.R123Q|MLST8_ENST00000382450.4_Missense_Mutation_p.R122Q|MLST8_ENST00000561651.1_3'UTR|MLST8_ENST00000565250.1_Missense_Mutation_p.R123Q|MLST8_ENST00000301724.10_Missense_Mutation_p.R123Q|MLST8_ENST00000301725.7_Missense_Mutation_p.R142Q	NM_022372.4	NP_071767.3	Q9BVC4	LST8_HUMAN	MTOR associated protein, LST8 homolog (S. cerevisiae)	123					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding			large_intestine(3)|lung(2)|skin(1)	6						CAGTGCCAGCGGATCTTCCAG	0.662000													13	64					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19211575	19211575	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19211575G>T	ENST00000263200.10	-	14	2203	c.2131C>A	c.(2131-2133)Ctc>Atc	p.L711I	CLTCL1_ENST00000353891.5_Missense_Mutation_p.L711I|CLTCL1_ENST00000427926.1_Missense_Mutation_p.L711I	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	711	Heavy chain arm.|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					AAGTAGAAGAGGCCTATGAAG	0.522000			T	?	ALCL								15	16					1.99824e-07	2.09433e-07	1	1	0
ZMIZ2	83637	broad.mit.edu	37	7	44800044	44800044	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44800044C>T	ENST00000309315.4	+	9	1215	c.1092C>T	c.(1090-1092)ggC>ggT	p.G364G	ZMIZ2_ENST00000433667.1_Silent_p.G332G|ZMIZ2_ENST00000441627.1_Silent_p.G364G|ZMIZ2_ENST00000413916.1_Silent_p.G306G|ZMIZ2_ENST00000265346.7_Silent_p.G338G	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	364	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CCATCCCGGGCTATCCCAGTT	0.597000													10	24					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37881050	37881050	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:37881050G>A	ENST00000406381.2	+	22	2799	c.2289G>A	c.(2287-2289)acG>acA	p.T763T	ERBB2_ENST00000445658.2_Silent_p.T517T|ERBB2_ENST00000269571.5_Silent_p.T793T|ERBB2_ENST00000584601.1_Silent_p.T763T|ERBB2_ENST00000541774.1_Silent_p.T778T|ERBB2_ENST00000584450.1_Silent_p.T793T|ERBB2_ENST00000540147.1_Silent_p.T763T	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	793	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.T793T(1)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TGACATCCACGGTGCAGCTGG	0.597000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			21	31					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	72998132	72998132	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:72998132C>T	ENST00000322038.5	+	2	1219	c.635C>T	c.(634-636)aCg>aTg	p.T212M	TSHZ1_ENST00000580243.1_Missense_Mutation_p.T257M	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	257						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		GCGTACGACACGCTGGTGGAA	0.602000													9	18					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80885101	80885101	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80885101C>T	ENST00000355528.4	+	29	2641	c.2511C>T	c.(2509-2511)gaC>gaT	p.D837D	TBCD_ENST00000539345.2_Silent_p.D837D	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	837					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			GAGCCCCAGACGAAGCTGTGT	0.527000													16	14					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34130191	34130191	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:34130191C>T	ENST00000389232.4	+	89	12080	c.12010C>T	c.(12010-12012)Cac>Tac	p.H4004Y	RYR3_ENST00000415757.3_Missense_Mutation_p.H3999Y	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	4004					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCTTTCTGAACACATGCCAAA	0.453000													41	78					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798489	55798489	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55798489C>T	ENST00000313555.1	+	1	595	c.595C>T	c.(595-597)Ctc>Ttc	p.L199F		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					CCAGCTTCTGCTCTTTGCTTT	0.423000													88	131					0	0	1	0	0
TPCN1	53373	broad.mit.edu	37	12	113664740	113664740	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:113664740G>A	ENST00000550785.1	+	3	468	c.299G>A	c.(298-300)gGc>gAc	p.G100D	TPCN1_ENST00000541517.1_Missense_Mutation_p.G100D|TPCN1_ENST00000335509.6_Missense_Mutation_p.G28D	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	28						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						CCCTCCAACGGCCTGGGCCAA	0.577000													10	15					0	0	1	0	0
KANSL1L	151050	broad.mit.edu	37	2	210896182	210896182	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:210896182C>A	ENST00000281772.9	-	9	2381	c.2118G>T	c.(2116-2118)caG>caT	p.Q706H	KANSL1L_ENST00000418791.1_Intron|AC007038.7_ENST00000452057.1_RNA	NM_152519.2	NP_689732.2	A0AUZ9	CB067_HUMAN	KAT8 regulatory NSL complex subunit 1-like	706																	TCTTTCTTCCCTGTAACAGTT	0.308000													8	68					5.18039e-06	5.37127e-06	1	1	0
ME1	4199	broad.mit.edu	37	6	83949258	83949258	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:83949258C>A	ENST00000369705.3	-	8	1028	c.912_splice	c.e8+1	p.E304_splice	ME1_ENST00000543031.1_Splice_Site_p.E229_splice|ME1_ENST00000541327.1_Splice_Site_p.E138_splice	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	304					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AGGCAAATACCTCTCCAGCTC	0.363000													20	30					6.33239e-15	6.92311e-15	1	1	0
MACF1	23499	broad.mit.edu	37	1	39827169	39827169	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:39827169C>T	ENST00000564288.1	+	49	13368	c.12591C>T	c.(12589-12591)ttC>ttT	p.F4197F	MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000567887.1_Silent_p.F4234F|MACF1_ENST00000539005.1_Silent_p.F2135F|MACF1_ENST00000372915.3_Silent_p.F4202F|MACF1_ENST00000361689.2_Silent_p.F2135F|MACF1_ENST00000317713.7_Silent_p.F2135F|MACF1_ENST00000289893.4_Silent_p.F2637F|MACF1_ENST00000545844.1_Silent_p.F2135F			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	4202					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCCAGCGGTTCGAACAGCTCT	0.547000													21	32					0	0	1	0	0
CHAT	1103	broad.mit.edu	37	10	50857557	50857557	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:50857557G>A	ENST00000395562.2	+	11	1609	c.1140G>A	c.(1138-1140)acG>acA	p.T380T	CHAT_ENST00000395559.2_Silent_p.T344T|CHAT_ENST00000337653.2_Silent_p.T462T|CHAT_ENST00000339797.1_Silent_p.T344T|CHAT_ENST00000351556.3_Silent_p.T344T|CHAT_ENST00000455728.2_Silent_p.T344T	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	462					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CCCGCAGGACGCAGAGCAGCA	0.607000													12	29					0	0	1	0	0
TCF3	6929	broad.mit.edu	37	19	1612209	1612209	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1612209G>A	ENST00000344749.5	-	18	1876	c.1810C>T	c.(1810-1812)Cga>Tga	p.R604*	TCF3_ENST00000262965.5_Intron|TCF3_ENST00000395423.3_Intron|TCF3_ENST00000588136.1_Nonsense_Mutation_p.R604*|TCF3_ENST00000453954.2_Nonsense_Mutation_p.R519*	NM_001136139.2	NP_001129611.1	P15923	TFE2_HUMAN	transcription factor 3	607	Helix-loop-helix motif.				B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCCTACCTCGCACCTGCTGC	0.672000			T	"""PBX1, HLF, TFPT"""	pre B-ALL								8	8					0	0	1	0	0
C2orf47	79568	broad.mit.edu	37	2	200828502	200828502	+	Missense_Mutation	SNP	G	G	A	rs140885188		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:200828502G>A	ENST00000295079.2	+	6	1166	c.844G>A	c.(844-846)Gca>Aca	p.A282T	C2orf47_ENST00000469156.1_3'UTR|C2orf47_ENST00000392290.1_Missense_Mutation_p.A282T	NM_024520.2	NP_078796.2	Q8WWC4	CB047_HUMAN	chromosome 2 open reading frame 47	282						mitochondrion		p.A282S(1)		cervix(1)|endometrium(2)|large_intestine(1)|lung(5)	9						CTGGACCATTGCACGGATTGA	0.353000													15	25					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80046115	80046115	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:80046115C>T	ENST00000306749.2	-	17	2880	c.2662G>A	c.(2662-2664)Gcc>Acc	p.A888T		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	888					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	TAGCCAGTGGCGGGGAAGAGG	0.662000													8	22					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102490635	102490635	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:102490635C>T	ENST00000321521.9	+	13	1964	c.1391C>T	c.(1390-1392)aCt>aTt	p.T464I	PPIP5K2_ENST00000414217.1_Missense_Mutation_p.T464I|PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000358359.3_Missense_Mutation_p.T464I			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	464					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CAACTTAAGACTGTATTAGAG	0.323000													23	36					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10478977	10478977	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10478977C>T	ENST00000525621.1	-	4	792	c.311G>A	c.(310-312)cGc>cAc	p.R104H	TYK2_ENST00000264818.6_Missense_Mutation_p.R104H|TYK2_ENST00000529370.1_Missense_Mutation_p.R104H|TYK2_ENST00000524462.1_Intron	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	104	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity	p.R104L(1)		breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCACCTTATGCGGAAATATAG	0.552000													39	44					0	0	1	0	0
SMCR7	0	broad.mit.edu	37	17	18167383	18167383	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18167383G>A	ENST00000323019.4	+	4	881	c.670G>A	c.(670-672)Gcc>Acc	p.A224T	SMCR7_ENST00000577216.1_3'UTR|SMCR7_ENST00000395706.2_Missense_Mutation_p.A235T|SMCR7_ENST00000395704.4_Missense_Mutation_p.G199D	NM_001144900.1|NM_139162.3	NP_001138372.1|NP_631901.2	Q96C03	SMCR7_HUMAN		224						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(4)	9	all_neural(463;0.228)					TCGCTGCTGGGCCGTGCGCAG	0.711000													4	2					0	0	1	0	0
SSH2	85464	broad.mit.edu	37	17	27958229	27958229	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27958229G>A	ENST00000269033.3	-	15	4053	c.3902C>T	c.(3901-3903)gCg>gTg	p.A1301V	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Missense_Mutation_p.A1328V	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	1301					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GTCCTCCATCGCGTGCATGCC	0.522000													22	40					0	0	1	0	0
SARM1	23098	broad.mit.edu	37	17	26722947	26722947	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26722947C>T	ENST00000457710.3	+	8	2316	c.1845C>T	c.(1843-1845)tgC>tgT	p.C615C	SLC46A1_ENST00000584729.1_5'UTR|SARM1_ENST00000379061.4_3'UTR|SLC46A1_ENST00000321666.5_3'UTR|SLC46A1_ENST00000440501.1_3'UTR	NM_015077.2	NP_055892.2	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	649	TIR.				innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity			cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CTTTAAGCTGCGGCAAGAACA	0.537000													26	39					0	0	1	0	0
IWS1	55677	broad.mit.edu	37	2	128262295	128262295	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128262295G>T	ENST00000295321.4	-	3	1443	c.1184C>A	c.(1183-1185)gCt>gAt	p.A395D	IWS1_ENST00000455721.2_Missense_Mutation_p.A402D|AC010976.2_ENST00000599001.1_RNA	NM_017969.2	NP_060439.2	Q96ST2	IWS1_HUMAN	IWS1 homolog (S. cerevisiae)	395	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(2)|kidney(6)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		AGAAAGCACAGCAGCTTTTCT	0.398000													46	100					1.62263e-30	1.81924e-30	1	1	0
PCDHB2	0	broad.mit.edu	37	5	140475758	140475758	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140475758G>A	ENST00000194155.4	+	1	1532	c.1384G>A	c.(1384-1386)Gtc>Atc	p.V462I		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		462	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCCTGTTCGTCCGCGAGAA	0.637000													13	118					0	0	1	0	0
METTL21A	151194	broad.mit.edu	37	2	208478148	208478148	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:208478148C>T	ENST00000411432.1	-	4	495	c.279G>A	c.(277-279)acG>acA	p.T93T	METTL21A_ENST00000426075.1_Silent_p.T93T|METTL21A_ENST00000272839.3_Silent_p.T111T|METTL21A_ENST00000432416.1_Intron|METTL21A_ENST00000442521.1_Silent_p.T93T|METTL21A_ENST00000406927.2_Silent_p.T93T|METTL21A_ENST00000448007.2_Silent_p.T93T|METTL21A_ENST00000448823.2_3'UTR|METTL21A_ENST00000425132.1_Intron|METTL21A_ENST00000458426.1_Intron	NM_001127395.1	NP_001120867.1	Q8WXB1	MT21A_HUMAN	methyltransferase like 21A	93						integral to membrane	methyltransferase activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|stomach(1)	10						CTTTTCGATCCGTGATAGTCA	0.388000													19	39					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132962330	132962330	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:132962330C>T	ENST00000254624.5	+	5	706	c.481C>T	c.(481-483)Cga>Tga	p.R161*	EFR3A_ENST00000334503.4_Nonsense_Mutation_p.R161*|EFR3A_ENST00000519656.1_Nonsense_Mutation_p.R125*	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	161						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TCCAGAAATACGAACAGAGTA	0.318000													3	11					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228462350	228462350	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228462350G>A	ENST00000570156.2	+	24	6960	c.6886G>A	c.(6886-6888)Gtg>Atg	p.V2296M	OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000366707.4_5'UTR|RP5-1139B12.3_ENST00000602529.1_RNA|OBSCN_ENST00000359599.6_Missense_Mutation_p.V768M|OBSCN_ENST00000422127.1_Missense_Mutation_p.V1921M|OBSCN_ENST00000284548.11_Missense_Mutation_p.V1921M	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1281	Ig-like 23.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTTCCAGTGCGTGGTGTCCCC	0.622000													8	15					0	0	1	0	0
HAPLN4	404037	broad.mit.edu	37	19	19371692	19371692	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19371692G>A	ENST00000291481.7	-	3	477	c.414C>T	c.(412-414)taC>taT	p.Y138Y	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	138	Ig-like C2-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			CATAGCGCCCGTAGTCTTGCA	0.632000													16	37					0	0	1	0	0
EDEM3	80267	broad.mit.edu	37	1	184675822	184675822	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:184675822C>T	ENST00000318130.8	-	18	2424	c.2158G>A	c.(2158-2160)Gca>Aca	p.A720T	EDEM3_ENST00000367512.3_Missense_Mutation_p.A677T|EDEM3_ENST00000466392.1_5'UTR	NM_025191.3	NP_079467.3	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like 3	720	PA.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						ATGTTGCGTGCCTTTTCTGCA	0.428000													22	21					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95522015	95522015	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:95522015G>A	ENST00000297591.5	-	15	3855	c.3780C>T	c.(3778-3780)ttC>ttT	p.F1260F	KIAA1429_ENST00000437199.1_Silent_p.F1260F|KIAA1429_ENST00000523405.1_5'UTR	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1260					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			AAAGATCCTGGAATATCTCTG	0.398000													23	30					0	0	1	0	0
MARK4	57787	broad.mit.edu	37	19	45805775	45805775	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45805775G>A	ENST00000262891.4	+	17	2397	c.2066G>A	c.(2065-2067)cGc>cAc	p.R689H	MARK4_ENST00000300843.4_3'UTR	NM_001199867.1	NP_001186796.1	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	689					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGCCGCTGCCGCCAGCCACAG	0.726000													19	20					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72964955	72964955	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:72964955C>T	ENST00000262209.4	-	14	1897	c.1690G>A	c.(1690-1692)Gtt>Att	p.V564I	RP11-383H13.1_ENST00000537896.1_3'UTR|RP11-383H13.1_ENST00000457356.4_3'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	564						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	AGAAGCGCAACGGCTTTGGCG	0.468000													43	49					0	0	1	0	0
ENO3	2027	broad.mit.edu	37	17	4860157	4860157	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4860157G>A	ENST00000323997.6	+	11	1340	c.1208G>A	c.(1207-1209)cGt>cAt	p.R403H	ENO3_ENST00000519584.1_Missense_Mutation_p.R360H|ENO3_ENST00000518175.1_Missense_Mutation_p.R403H	NM_001976.4|NM_053013.3	NP_001967.3|NP_443739.3	P13929	ENOB_HUMAN	enolase 3 (beta, muscle)	403					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)	15						CGCTCGGAGCGTCTGGCCAAA	0.587000											OREG0024110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	70					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18858171	18858171	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:18858171G>A	ENST00000266505.7	-	7	1056	c.793C>T	c.(793-795)Cag>Tag	p.Q265*	PLCZ1_ENST00000542762.1_5'UTR|PLCZ1_ENST00000447925.2_Nonsense_Mutation_p.Q263*|PLCZ1_ENST00000539875.1_Nonsense_Mutation_p.Q72*|PLCZ1_ENST00000541695.1_Nonsense_Mutation_p.Q128*|PLCZ1_ENST00000538330.1_Nonsense_Mutation_p.Q6*|PLCZ1_ENST00000435379.1_Nonsense_Mutation_p.Q70*			Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	265	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AAAGTAGCCTGCAAATTGTCT	0.398000													8	80					0	0	1	0	0
DFFA	1676	broad.mit.edu	37	1	10523527	10523527	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:10523527C>T	ENST00000377038.3	-	4	659	c.592G>A	c.(592-594)Gct>Act	p.A198T	DFFA_ENST00000377036.2_Missense_Mutation_p.A198T	NM_004401.2	NP_004392.1	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha polypeptide	198					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding			large_intestine(3)|lung(2)	5	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		TTCTCCAAAGCCTGGAGGTAC	0.572000													41	53					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173852994	173852994	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:173852994C>T	ENST00000264111.6	+	13	1405	c.1218C>T	c.(1216-1218)taC>taT	p.Y406Y	RAPGEF4_ENST00000540783.1_Silent_p.Y254Y|RAPGEF4_ENST00000535187.1_Silent_p.Y187Y|RAPGEF4_ENST00000538974.1_Silent_p.Y236Y|RAPGEF4_ENST00000409036.1_Silent_p.Y407Y|RAPGEF4_ENST00000539331.1_Silent_p.Y254Y|RAPGEF4_ENST00000397081.3_Silent_p.Y407Y|RAPGEF4_ENST00000397087.3_Silent_p.Y263Y|RAPGEF4_ENST00000473043.1_3'UTR			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	407					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TAGTCATTTACGGCAAGGTAT	0.348000													18	54					0	0	1	0	0
TICAM2	353376	broad.mit.edu	37	5	114916397	114916397	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:114916397G>A	ENST00000408996.4	-	4	1450	c.1064C>T	c.(1063-1065)cCc>cTc	p.P355L	TMED7-TICAM2_ENST00000333314.3_3'UTR|TMED7-TICAM2_ENST00000282382.4_Missense_Mutation_p.P355L|TICAM2_ENST00000427199.2_Missense_Mutation_p.P186L	NM_001164468.2|NM_001164469.2	NP_001157940.1|NP_001157941.1			toll-like receptor adaptor molecule 2											cervix(1)|kidney(1)|lung(2)|soft_tissue(1)	5		all_cancers(142;0.0223)|all_epithelial(76;0.000869)|Prostate(80;0.0115)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;4.38e-07)|Epithelial(69;1.62e-06)|all cancers(49;6.93e-05)		GAGGGCAAAGGGAGTCCTTTC	0.443000													4	59					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47704923	47704923	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:47704923A>G	ENST00000397708.1	-	2	532	c.278T>C	c.(277-279)tTt>tCt	p.F93S	MCM3AP_ENST00000291688.1_Missense_Mutation_p.F93S			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	93					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					GGTAGCCACAAAGGTGGAAGT	0.483000													15	5					0	0	1	0	0
TRAV36DV7	0	broad.mit.edu	37	14	22695104	22695104	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22695104G>T	ENST00000390463.3	+	0	311																											GAACATCACAGCCACCCAGAC	0.458000													6	8					2.0095e-06	2.09073e-06	1	1	0
SUMF2	25870	broad.mit.edu	37	7	56146174	56146174	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:56146174C>T	ENST00000434526.2	+	8	882	c.851C>T	c.(850-852)gCc>gTc	p.A284V	SUMF2_ENST00000395435.2_Missense_Mutation_p.A200V|SUMF2_ENST00000395436.2_Missense_Mutation_p.A269V|SUMF2_ENST00000275607.9_Missense_Mutation_p.A177V|SUMF2_ENST00000342190.6_Intron|SUMF2_ENST00000437307.2_Missense_Mutation_p.A196V|SUMF2_ENST00000413756.1_Missense_Mutation_p.A265V	NM_001042469.1|NM_015411.2	NP_001035934.2|NP_056226.2	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2	265						endoplasmic reticulum lumen	metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	14	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GATGGCTCTGCCAATCACCGG	0.647000													6	14					0	0	1	0	0
NFYB	4801	broad.mit.edu	37	12	104517076	104517076	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104517076G>A	ENST00000240055.3	-	5	584	c.357C>T	c.(355-357)ctC>ctT	p.L119L	NFYB_ENST00000551727.1_Silent_p.L119L	NM_006166.3	NP_006157.1	P25208	NFYB_HUMAN	nuclear transcription factor Y, beta	119	B domain.					CCAAT-binding factor complex	repressing transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	6						ACATAGCAAAGAGAATATCTT	0.348000													25	36					0	0	1	0	0
PIP4K2B	8396	broad.mit.edu	37	17	36936738	36936738	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36936738C>T	ENST00000269554.3	-	4	954	c.474G>A	c.(472-474)gcG>gcA	p.A158A	PIP4K2B_ENST00000311500.6_5'UTR	NM_003559.4	NP_003550.1	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	158	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)	19						TGTGCATCTCCGCCACGTCCT	0.582000													32	52					0	0	1	0	0
ZNF598	90850	broad.mit.edu	37	16	2049773	2049773	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2049773C>T	ENST00000563630.1	-	9	1854	c.1612G>A	c.(1612-1614)Gtg>Atg	p.V538M	ZNF598_ENST00000431526.1_Missense_Mutation_p.V593M|ZNF598_ENST00000562103.1_Missense_Mutation_p.V538M			Q86UK7	ZN598_HUMAN	zinc finger protein 598	593						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						TCCGAGCCCACTTTCTTCTTC	0.657000													9	19					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78011943	78011943	+	Silent	SNP	G	G	A	rs141650385	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78011943G>A	ENST00000397545.4	+	2	78	c.51G>A	c.(49-51)tcG>tcA	p.S17S	CCDC40_ENST00000374877.3_Silent_p.S17S|CCDC40_ENST00000374876.4_Silent_p.S17S|CCDC40_ENST00000269318.5_Silent_p.S17S	NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	17					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AAGATGGATCGGCTTCTGAGG	0.418000													20	24					0	0	1	0	0
NEK6	10783	broad.mit.edu	37	9	127113178	127113178	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:127113178C>T	ENST00000373600.3	+	11	1211	c.996C>T	c.(994-996)taC>taT	p.Y332Y	NEK6_ENST00000394199.2_Silent_p.Y332Y|NEK6_ENST00000320246.5_Silent_p.Y298Y|NEK6_ENST00000546191.1_Silent_p.Y298Y|NEK6_ENST00000540326.1_Silent_p.Y316Y|NEK6_ENST00000373603.1_Silent_p.Y298Y|NEK6_ENST00000539416.1_Silent_p.Y323Y|NEK6_ENST00000545174.1_Silent_p.Y298Y	NM_001145001.2	NP_001138473.1	Q9HC98	NEK6_HUMAN	NIMA-related kinase 6	298					apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity	p.Y291Y(1)		endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15						ACATCGGATACGTGCACCAGG	0.542000													6	9					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120575043	120575043	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:120575043G>A	ENST00000300648.6	-	50	6756	c.6744C>T	c.(6742-6744)ggC>ggT	p.G2248G		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	2248					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCACATGCTCGCCTTTGCTCT	0.577000													59	69					0	0	1	0	0
ANGPT4	51378	broad.mit.edu	37	20	896759	896759	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:896759G>A	ENST00000381922.3	-	1	201	c.99C>T	c.(97-99)tgC>tgT	p.C33C	ANGPT4_ENST00000546022.1_Silent_p.C33C	NM_015985.2	NP_057069.1	Q9Y264	ANGP4_HUMAN	angiopoietin 4	33					anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	27						CAAGTGTCTCGCAGCCCCTAT	0.612000													18	23					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111441445	111441445	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:111441445C>T	ENST00000265162.5	+	10	1992	c.1650C>T	c.(1648-1650)aaC>aaT	p.N550N		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	550					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TTAACGTGAACGGTGTCAAGA	0.443000													33	43					0	0	1	0	0
LIPC	3990	broad.mit.edu	37	15	58830668	58830668	+	Silent	SNP	C	C	T	rs146362585	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:58830668C>T	ENST00000414170.3	+	3	512	c.225C>T	c.(223-225)tgC>tgT	p.C75C	LIPC_ENST00000433326.2_Silent_p.C75C|LIPC_ENST00000356113.6_Silent_p.C75C|LIPC_ENST00000299022.5_Silent_p.C75C			P11150	LIPC_HUMAN	lipase, hepatic	75					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity	p.C75C(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TACAGGAGTGCGGCTTCAACT	0.473000													13	108					0	0	1	0	0
ZNF778	197320	broad.mit.edu	37	16	89294899	89294899	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:89294899G>T	ENST00000433976.2	+	6	2451	c.2119G>T	c.(2119-2121)Gga>Tga	p.G707*	RP11-46C24.6_ENST00000563182.1_RNA|ZNF778_ENST00000306502.6_Nonsense_Mutation_p.G665*	NM_001201407.1|NM_182531.3	NP_001188336.1|NP_872337.2	Q96MU6	ZN778_HUMAN	zinc finger protein 778	707					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|skin(2)	24				BRCA - Breast invasive adenocarcinoma(80;0.0269)		TAAGGACTGTGGAAAATCTTT	0.343000													18	45					8.34094e-07	8.70022e-07	1	1	0
HEBP1	50865	broad.mit.edu	37	12	13140127	13140127	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:13140127G>A	ENST00000536942.1	-	3	507	c.357C>T	c.(355-357)agC>agT	p.S119S	HEBP1_ENST00000014930.4_Silent_p.S119S			Q9NRV9	HEBP1_HUMAN	heme binding protein 1	119					circadian rhythm	extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	7		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.153)		CAATCTTAACGCTTTTGTCAC	0.483000													6	128					0	0	1	0	0
TMIGD2	126259	broad.mit.edu	37	19	4292775	4292775	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4292775T>A	ENST00000301272.2	-	5	715	c.670A>T	c.(670-672)Acc>Tcc	p.T224S	TMIGD2_ENST00000600349.1_Missense_Mutation_p.T52S|TMIGD2_ENST00000595645.1_Missense_Mutation_p.T220S|TMIGD2_ENST00000600114.1_Missense_Mutation_p.T104S	NM_001169126.1|NM_144615.2	NP_001162597.1|NP_653216.2	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain containing 2	224						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(2)	19				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGAAGGAGGTTGAATAAATG	0.677000													13	42					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3030068	3030068	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:3030068C>T	ENST00000397461.1	+	13	1782	c.1398C>T	c.(1396-1398)aaC>aaT	p.N466N	CNTN4_ENST00000397459.2_Silent_p.N138N|CNTN4_ENST00000358480.3_Silent_p.N247N|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000448906.2_Silent_p.N138N|CNTN4_ENST00000418658.1_Silent_p.N466N|CNTN4_ENST00000427331.1_Silent_p.N466N	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	466	Ig-like C2-type 5.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GAATCATCAACGTTACTAAAT	0.363000													8	105					0	0	1	0	0
ZNF467	168544	broad.mit.edu	37	7	149462733	149462733	+	Silent	SNP	G	G	A	rs3194380		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149462733G>A	ENST00000302017.3	-	5	1271	c.858C>T	c.(856-858)caC>caT	p.H286H	ZNF467_ENST00000484747.1_Intron	NM_207336.1	NP_997219.1	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|urinary_tract(1)	13	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCGAATCAAGTGCGTCTTCT	0.622000													5	6					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20476858	20476858	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:20476858G>A	ENST00000573854.1	+	3	311	c.197G>A	c.(196-198)aGc>aAc	p.S66N	ACSM2A_ENST00000575690.1_Missense_Mutation_p.S66N|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000536134.1_5'UTR|ACSM2A_ENST00000424070.1_Missense_Mutation_p.S66N|ACSM2A_ENST00000219054.6_Missense_Mutation_p.S66N|ACSM2A_ENST00000396104.2_Missense_Mutation_p.S66N|ACSM2A_ENST00000417235.2_5'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	66					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						CGACTCCCAAGCCCAGCCCTG	0.527000													7	32					0	0	1	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118005506	118005506	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:118005506G>A	ENST00000310754.4	-	1	1230	c.1044C>T	c.(1042-1044)aaC>aaT	p.N348N		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	348					protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						CTCCCACTCCGTTTTCTGTTC	0.393000													6	196					0	0	1	0	0
B4GALNT4	338707	broad.mit.edu	37	11	376473	376473	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:376473C>T	ENST00000329962.6	+	14	1350	c.1350C>T	c.(1348-1350)acC>acT	p.T450T		NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4	450	Pro-rich.					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGAGCCCACCGAGGCGGCCC	0.781000													6	9					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177036685	177036685	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:177036685C>T	ENST00000468418.3	+	4	3072	c.982C>T	c.(982-984)Cgc>Tgc	p.R328C	HOXD3_ENST00000249440.3_Missense_Mutation_p.R328C|HOXD3_ENST00000410016.1_Missense_Mutation_p.R328C			P31249	HXD3_HUMAN	homeobox D3	328					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		ACAACAGAAGCGCTACGCAGC	0.682000													6	4					0	0	1	0	0
IL10	3586	broad.mit.edu	37	1	206944740	206944740	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:206944740G>A	ENST00000423557.1	-	2	244	c.186C>T	c.(184-186)gaC>gaT	p.D62D		NM_000572.2	NP_000563.1	P22301	IL10_HUMAN	interleukin 10	62					anti-apoptosis|B cell differentiation|B cell proliferation|cytoplasmic sequestering of NF-kappaB|inflammatory response|leukocyte chemotaxis|negative regulation of B cell proliferation|negative regulation of cytokine secretion involved in immune response|negative regulation of interferon-alpha biosynthetic process|negative regulation of interleukin-6 production|negative regulation of membrane protein ectodomain proteolysis|negative regulation of MHC class II biosynthetic process|negative regulation of T cell proliferation|positive regulation of B cell apoptosis|positive regulation of cytokine secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|receptor biosynthetic process|regulation of isotype switching|response to glucocorticoid stimulus|type 2 immune response	extracellular space	cytokine activity|growth factor activity|interleukin-10 receptor binding			endometrium(1)|large_intestine(6)|lung(4)|prostate(1)	12	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			ACAACAAGTtgtccagctgat	0.478000													7	3					0	0	1	0	0
MTG2	26164	broad.mit.edu	37	20	60773769	60773769	+	Missense_Mutation	SNP	C	C	T	rs138156304	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:60773769C>T	ENST00000370823.3	+	5	566	c.548C>T	c.(547-549)gCg>gTg	p.A183V	MTG2_ENST00000436421.2_Intron|MTG2_ENST00000536470.1_5'UTR|MTG2_ENST00000461411.1_3'UTR	NM_015666.3	NP_056481.1			mitochondrial ribosome-associated GTPase 2																		TACATTGCCGCGCTGGGCGGG	0.637000													11	17					0	0	1	0	0
FAM83E	54854	broad.mit.edu	37	19	49113195	49113195	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49113195G>A	ENST00000263266.3	-	3	885	c.696C>T	c.(694-696)agC>agT	p.S232S		NM_017708.3	NP_060178.2	Q2M2I3	FA83E_HUMAN	family with sequence similarity 83, member E	232								p.S232R(1)		NS(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(2)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GCACGGTGCCGCTCACCTGCC	0.672000													14	11					0	0	1	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65197639	65197639	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:65197639G>A	ENST00000247226.7	+	4	829	c.521G>A	c.(520-522)cGc>cAc	p.R174H	PLEKHG3_ENST00000394691.1_Missense_Mutation_p.R230H	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	230	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CCAGTCCAGCGCATCCTCAAG	0.652000													14	22					0	0	1	0	0
DPY19L2P2	0	broad.mit.edu	37	7	102837736	102837736	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:102837736C>T	ENST00000312132.4	-	0	3435																											CTAACAACTGCAATGTGTGAA	0.313000													8	19					0	0	1	0	0
RFPL3	10738	broad.mit.edu	37	22	32756259	32756259	+	Missense_Mutation	SNP	G	G	A	rs146565766	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:32756259G>A	ENST00000249007.4	+	2	599	c.394G>A	c.(394-396)Gac>Aac	p.D132N	RFPL3S_ENST00000382084.4_3'UTR|RFPL3_ENST00000382088.3_Missense_Mutation_p.D103N|RFPL3S_ENST00000400234.1_3'UTR|RFPL3_ENST00000397468.1_Missense_Mutation_p.D103N	NM_001098535.1	NP_001092005.1	O75679	RFPL3_HUMAN	ret finger protein-like 3	132	B30.2/SPRY.						zinc ion binding	p.D132Y(1)|p.D103Y(1)		cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|stomach(1)	15						CTTGGATGCCGACACAGCCAA	0.502000													4	66					0	0	1	0	0
STAM2	10254	broad.mit.edu	37	2	153003752	153003752	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:153003752G>T	ENST00000263904.4	-	5	720	c.371C>A	c.(370-372)cCt>cAt	p.P124H	STAM2_ENST00000465460.1_5'UTR	NM_005843.4	NP_005834.4	O75886	STAM2_HUMAN	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	124	VHS.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)	16				BRCA - Breast invasive adenocarcinoma(221;0.22)		ACTAAACTGAGGGTCCTTCTG	0.363000													35	66					3.11337e-16	3.41621e-16	1	1	0
HECTD2	143279	broad.mit.edu	37	10	93244322	93244322	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:93244322C>T	ENST00000446394.1	+	10	992	c.892C>T	c.(892-894)Cgc>Tgc	p.R298C	HECTD2_ENST00000498446.1_3'UTR|HECTD2_ENST00000536715.1_5'UTR|HECTD2_ENST00000298068.5_Missense_Mutation_p.R294C|HECTD2_ENST00000371667.1_5'UTR			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	294					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						TATTTCTTTACGCCTGTTTCC	0.368000													48	58					0	0	1	0	0
CUTC	51076	broad.mit.edu	37	10	101507076	101507076	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:101507076C>T	ENST00000370476.5	+	6	631	c.502C>T	c.(502-504)Cgc>Tgc	p.R168C		NM_015960.2	NP_057044.2	Q9NTM9	CUTC_HUMAN	cutC copper transporter	168					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		GGGATTTGAACGCGTGTTGAC	0.428000													26	59					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16215871	16215871	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:16215871G>A	ENST00000399408.2	+	25	3635	c.3460G>A	c.(3460-3462)Gag>Aag	p.E1154K	ABCC1_ENST00000346370.5_Missense_Mutation_p.E1088K|ABCC1_ENST00000399410.3_Missense_Mutation_p.E1144K|ABCC1_ENST00000351154.5_Missense_Mutation_p.E1085K|ABCC1_ENST00000345148.5_Missense_Mutation_p.E1144K|ABCC1_ENST00000349029.5_Missense_Mutation_p.E1029K			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	1144	ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GAAGCGCCTCGAGTCGGTCAG	0.617000													9	24					0	0	1	0	0
TAF1B	9014	broad.mit.edu	37	2	10022928	10022928	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:10022928T>C	ENST00000263663.5	+	8	989	c.801T>C	c.(799-801)ggT>ggC	p.G267G	TAF1B_ENST00000396242.3_Silent_p.G12G	NM_005680.2	NP_005671.2	Q53T94	TAF1B_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	267					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GAATCTTTGGTATAGAGGTAA	0.323000													23	34					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92848530	92848530	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:92848530G>A	ENST00000394468.2	-	2	391	c.314C>T	c.(313-315)gCa>gTa	p.A105V	HEPACAM2_ENST00000453812.2_Missense_Mutation_p.A128V|HEPACAM2_ENST00000440868.1_Missense_Mutation_p.A93V|HEPACAM2_ENST00000341723.4_Missense_Mutation_p.A93V	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	105						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						AAGCAGAGATGCATTGGGTGG	0.458000													4	53					0	0	1	0	0
WDR59	79726	broad.mit.edu	37	16	74950052	74950052	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:74950052G>A	ENST00000262144.6	-	12	1202	c.1072C>T	c.(1072-1074)Cac>Tac	p.H358Y		NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	358										breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						CTTGCAGTGTGCTGGTGATCT	0.473000													23	30					0	0	1	0	0
EDEM2	55741	broad.mit.edu	37	20	33722573	33722573	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:33722573G>A	ENST00000540582.1	-	10	1268	c.547C>T	c.(547-549)Cgc>Tgc	p.R183C	EDEM2_ENST00000374491.2_Missense_Mutation_p.R187C|EDEM2_ENST00000542871.1_Intron|EDEM2_ENST00000374492.3_Missense_Mutation_p.R224C|EDEM2_ENST00000541621.1_5'UTR			Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like 2	224					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	22			BRCA - Breast invasive adenocarcinoma(18;0.00936)			TCCCAGAGGCGCATCAAAGCC	0.572000													8	19					0	0	1	0	0
CHRNA10	57053	broad.mit.edu	37	11	3688730	3688730	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3688730C>T	ENST00000534359.1	-	4	676	c.80G>A	c.(79-81)cGc>cAc	p.R27H	CHRNA10_ENST00000250699.2_Silent_p.A209A			Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10 (neuronal)	353					elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			breast(1)|endometrium(2)|lung(3)|ovary(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	CGCGCCGCCGCGCCGGCATGC	0.736000													4	16					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20766690	20766690	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:20766690C>T	ENST00000404938.2	+	22	3305	c.2653C>T	c.(2653-2655)Cgt>Tgt	p.R885C	ABCB5_ENST00000258738.6_Missense_Mutation_p.R440C	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	440					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						GGAGAATATACGTACTATAGT	0.323000													14	28					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103364241	103364241	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:103364241C>T	ENST00000358392.2	-	56	4582	c.4265G>A	c.(4264-4266)cGg>cAg	p.R1422Q	COL11A1_ENST00000353414.4_Missense_Mutation_p.R1371Q|COL11A1_ENST00000370096.3_Missense_Mutation_p.R1410Q|COL11A1_ENST00000512756.1_Missense_Mutation_p.R1294Q	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1410	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGGGATGCCCCGAAGACCTTC	0.458000													11	26					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4917398	4917398	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:4917398G>A	ENST00000399583.3	-	2	560	c.373C>T	c.(373-375)Cgg>Tgg	p.R125W	RADIL_ENST00000536091.1_Missense_Mutation_p.R125W	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	125	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GCCTGCCACCGCTGCCCAGCA	0.637000													6	55					0	0	1	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643374	37643374	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:37643374G>A	ENST00000356958.4	-	5	1685	c.1427C>T	c.(1426-1428)aCc>aTc	p.T476I	ZNF585A_ENST00000355533.2_Intron|ZNF585A_ENST00000392157.2_Missense_Mutation_p.T421I|ZNF585A_ENST00000292841.5_Missense_Mutation_p.T421I|ZNF585A_ENST00000588723.1_Intron			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	476					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGACCGGTTGGTGAATGCCTT	0.413000													27	170					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202910745	202910745	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:202910745G>A	ENST00000340990.5	-	8	1382	c.1084C>T	c.(1084-1086)Cgt>Tgt	p.R362C	ADIPOR1_ENST00000436244.1_Missense_Mutation_p.R362C	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	362					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			AGGCCGTAACGGAATTCCTGA	0.493000													8	46					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108384689	108384689	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:108384689A>G	ENST00000265843.4	-	6	1655	c.1545T>C	c.(1543-1545)aaT>aaC	p.N515N	EXPH5_ENST00000525344.1_Silent_p.N508N|EXPH5_ENST00000524840.1_5'UTR|EXPH5_ENST00000428840.1_Silent_p.N439N|EXPH5_ENST00000443411.1_Silent_p.N327N	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	515					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTGATACACTATTTGCTTCCA	0.413000													34	49					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32029957	32029957	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32029957G>A	ENST00000375244.3	-	20	7346	c.7145C>T	c.(7144-7146)cCc>cTc	p.P2382L	TNXB_ENST00000375247.2_Missense_Mutation_p.P2382L			P22105	TENX_HUMAN	tenascin XB	2444	Fibronectin type-III 16.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GGCAGACACGGGGCCCACACG	0.627000													19	23					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105353125	105353125	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105353125C>T	ENST00000453495.1	+	12	2780	c.2552C>T	c.(2551-2553)cCt>cTt	p.P851L	CEP170B_ENST00000418279.1_Missense_Mutation_p.P780L|CEP170B_ENST00000414716.3_Missense_Mutation_p.P850L|CEP170B_ENST00000556508.1_Missense_Mutation_p.P780L					centrosomal protein 170B																		CAGCTACGGCCTGGACGGTCC	0.677000													4	26					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37884170	37884170	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:37884170G>A	ENST00000406381.2	+	29	4061	c.3551G>A	c.(3550-3552)aGc>aAc	p.S1184N	ERBB2_ENST00000445658.2_Missense_Mutation_p.S938N|ERBB2_ENST00000269571.5_Missense_Mutation_p.S1214N|ERBB2_ENST00000584601.1_Missense_Mutation_p.S1184N|ERBB2_ENST00000541774.1_Missense_Mutation_p.S1199N|ERBB2_ENST00000584450.1_3'UTR|ERBB2_ENST00000540147.1_Missense_Mutation_p.S1184N	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	1214					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CCTGCCTTCAGCCCAGCCTTC	0.622000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			19	22					0	0	1	0	0
EXTL1	2134	broad.mit.edu	37	1	26361404	26361404	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:26361404A>G	ENST00000374280.3	+	10	2624	c.1757A>G	c.(1756-1758)gAc>gGc	p.D586G		NM_004455.2	NP_004446.2	Q92935	EXTL1_HUMAN	exostosin-like glycosyltransferase 1	586					skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|stomach(1)|urinary_tract(1)	23		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTGTGTGGACGTCCTGATG	0.582000													54	86					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214171121	214171121	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:214171121G>A	ENST00000366958.4	+	2	1851	c.1243G>A	c.(1243-1245)Gtc>Atc	p.V415I	PROX1_ENST00000498508.2_Missense_Mutation_p.V415I|PROX1_ENST00000435016.1_Missense_Mutation_p.V415I|PROX1_ENST00000261454.4_Missense_Mutation_p.V415I	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	415					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CTTTGGCGACGTCATCATTCC	0.567000													21	55					0	0	1	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65208801	65208801	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:65208801G>A	ENST00000247226.7	+	14	2706	c.2398G>A	c.(2398-2400)Gcc>Acc	p.A800T	PLEKHG3_ENST00000394691.1_Missense_Mutation_p.A856T|PLEKHG3_ENST00000492928.1_Intron|PLEKHG3_ENST00000471182.2_Missense_Mutation_p.A389T|PLEKHG3_ENST00000484731.2_Missense_Mutation_p.A361T	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	856					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TGAGCTGGGAGCCATCACAGA	0.662000													12	24					0	0	1	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555064	44555064	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:44555064C>T	ENST00000330682.2	-	1	1385	c.1150G>A	c.(1150-1152)Gca>Aca	p.A384T	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	384	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						CGAGCGAGTGCGGCATTGTCT	0.572000													23	908					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	457049	457049	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:457049C>T	ENST00000512944.1	+	5	1281	c.1092C>T	c.(1090-1092)gtC>gtT	p.V364V	EXOC3_ENST00000315013.5_Silent_p.V364V	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	375					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AAGTGGATGTCGGCACCCTGG	0.567000													11	18					0	0	1	0	0
BPIFB3	359710	broad.mit.edu	37	20	31643282	31643282	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31643282C>T	ENST00000375494.3	+	1	53	c.53C>T	c.(52-54)gCg>gTg	p.A18V		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	18	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding	p.A18V(1)									TGGGGCCTGGCGACTCCATGC	0.607000													8	41					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11505719	11505719	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:11505719C>T	ENST00000379237.1	-	15	1602	c.1208G>A	c.(1207-1209)aGg>aAg	p.R403K	USP6NL_ENST00000277575.5_Missense_Mutation_p.R420K	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	403						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						CCCGCTCTCCCTCCTGCCGCT	0.692000													4	11					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49657622	49657622	+	Silent	SNP	G	G	A	rs142129715		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49657622G>A	ENST00000252825.4	-	1	1059	c.873C>T	c.(871-873)cgC>cgT	p.R291R	HRC_ENST00000595625.1_Silent_p.R291R	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	291	4 X tandem repeats, acidic.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		GGCTGGGGTCGCGATGATGGT	0.512000													20	37					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20517421	20517421	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:20517421C>T	ENST00000202677.6	-	25	3435	c.3293G>A	c.(3292-3294)cGt>cAt	p.R1098H		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	1098					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						AGCCTCTGAACGAGGCGCCTG	0.433000													3	11					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16675191	16675191	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:16675191G>A	ENST00000513610.1	-	35	5189	c.4735C>T	c.(4735-4737)Ctg>Ttg	p.L1579L	MYO10_ENST00000427430.2_Silent_p.L936L|MYO10_ENST00000505695.1_Silent_p.L918L|MYO10_ENST00000274203.9_Silent_p.L936L|MYO10_ENST00000515803.1_Silent_p.L918L	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1579	MyTH4.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						ATGGACTCCAGTTGCTGCAGG	0.498000													11	19					0	0	1	0	0
ELOF1	84337	broad.mit.edu	37	19	11664579	11664579	+	Silent	SNP	G	G	A	rs139453256		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11664579G>A	ENST00000587806.1	-	5	454	c.297C>T	c.(295-297)tgC>tgT	p.C99C	ELOF1_ENST00000252445.3_Silent_p.C78C|ELOF1_ENST00000591674.1_Silent_p.C85C|ELOF1_ENST00000591912.1_3'UTR|ELOF1_ENST00000590700.1_Silent_p.C78C|ELOF1_ENST00000589171.1_3'UTR|ELOF1_ENST00000586683.1_Intron|ELOF1_ENST00000586120.1_Silent_p.C78C			P60002	ELOF1_HUMAN	elongation factor 1 homolog (S. cerevisiae)	78					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			endometrium(3)|lung(2)	5						TGGCCGCCTCGCAGGCGTCTA	0.592000													13	25					0	0	1	0	0
BCAR3	8412	broad.mit.edu	37	1	94049651	94049651	+	Silent	SNP	G	G	A	rs143814614		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:94049651G>A	ENST00000370244.1	-	8	1245	c.957C>T	c.(955-957)ccC>ccT	p.P319P	BCAR3_ENST00000370247.3_Silent_p.P228P|BCAR3_ENST00000466632.1_5'UTR|BCAR3_ENST00000260502.6_Silent_p.P319P|BCAR3_ENST00000370243.1_Silent_p.P319P|BCAR3_ENST00000539242.1_5'UTR	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	319					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding	p.P319P(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CCAGGCAGGCGGGCTGGCTAC	0.468000													22	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179639725	179639725	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179639725G>A	ENST00000589042.1	-	29	6937	c.6713C>T	c.(6712-6714)aCg>aTg	p.T2238M	TTN_ENST00000342175.6_Missense_Mutation_p.T2192M|TTN_ENST00000360870.5_Missense_Mutation_p.T2238M|TTN_ENST00000591111.1_Missense_Mutation_p.T2238M|TTN_ENST00000460472.2_Missense_Mutation_p.T2192M|TTN_ENST00000342992.6_Missense_Mutation_p.T2238M|TTN_ENST00000359218.5_Missense_Mutation_p.T2192M	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1970	Ig-like 11.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCATCAGACGTATCAATGGT	0.393000													10	40					0	0	1	0	0
SPRR2D	6703	broad.mit.edu	37	1	153012804	153012804	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:153012804G>A	ENST00000368757.1	-	2	299	c.19C>T	c.(19-21)Cag>Tag	p.Q7*	SPRR2D_ENST00000368756.1_Nonsense_Mutation_p.Q7*|SPRR2D_ENST00000360379.3_Nonsense_Mutation_p.Q7*|SPRR2D_ENST00000368758.3_Nonsense_Mutation_p.Q7*			P22532	SPR2D_HUMAN	small proline-rich protein 2D	7					keratinization	cornified envelope|cytoplasm				endometrium(1)|skin(1)	2	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGCTTGCACTGCTGCTGTTGA	0.557000													11	53					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16780631	16780631	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:16780631A>G	ENST00000513610.1	-	8	1281		c.e8+1			NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X						axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						CGTCCCACTCACCTCTTTCTT	0.403000													4	3					0	0	1	0	0
C4orf19	55286	broad.mit.edu	37	4	37592465	37592465	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:37592465C>T	ENST00000284437.6	+	3	966	c.788C>T	c.(787-789)gCc>gTc	p.A263V	C4orf19_ENST00000381980.4_Missense_Mutation_p.A263V|RELL1_ENST00000314117.4_3'UTR|C4orf19_ENST00000508175.1_Intron	NM_018302.2	NP_060772.2	Q8IY42	CD019_HUMAN	chromosome 4 open reading frame 19	263										large_intestine(1)|lung(3)|skin(3)|stomach(1)|urinary_tract(1)	9						CCTGTTCATGCCATGCCTGTG	0.522000													22	33					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24582104	24582104	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:24582104C>T	ENST00000358321.3	+	9	1721	c.1460C>T	c.(1459-1461)gCc>gTc	p.A487V		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	487	VWFD.				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						CAGGCGCGGGCCCAGCCCGGG	0.652000													8	11					0	0	1	0	0
ULK1	8408	broad.mit.edu	37	12	132403156	132403156	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:132403156C>T	ENST00000321867.4	+	23	2792	c.2441C>T	c.(2440-2442)cCc>cTc	p.P814L	ULK1_ENST00000540647.1_Missense_Mutation_p.P59L	NM_003565.2	NP_003556.1	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	814					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TTTGCCGACCCCATTACTGCG	0.667000													5	6					0	0	1	0	0
NCDN	23154	broad.mit.edu	37	1	36029409	36029409	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:36029409C>T	ENST00000373243.2	+	6	2035	c.1652C>T	c.(1651-1653)aCg>aTg	p.T551M	NCDN_ENST00000373253.3_Missense_Mutation_p.T534M|NCDN_ENST00000356090.4_Missense_Mutation_p.T551M	NM_014284.2	NP_055099.1	Q9UBB6	NCDN_HUMAN	neurochondrin	551					neuron projection development	cytosol|dendrite|neuronal cell body				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|pancreas(1)|skin(2)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACCCTCATGACGTCGCTACCA	0.572000													12	72					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46494520	46494520	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:46494520G>A	ENST00000361297.2	+	18	2416	c.2133G>A	c.(2131-2133)atG>atA	p.M711I	MAST2_ENST00000372009.2_Missense_Mutation_p.M641I|MAST2_ENST00000372008.1_Missense_Mutation_p.M596I	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	711	Protein kinase.				regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GGTGGGCCATGGGCATTATCC	0.572000													54	100					0	0	1	0	0
DCAF11	0	broad.mit.edu	37	14	24588974	24588974	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24588974C>T	ENST00000446197.3	+	11	1688	c.961C>T	c.(961-963)Caa>Taa	p.Q321*	DCAF11_ENST00000396941.4_Nonsense_Mutation_p.Q295*|DCAF11_ENST00000559115.1_Nonsense_Mutation_p.Q321*|DCAF11_ENST00000396936.1_Nonsense_Mutation_p.Q221*	NM_025230.4	NP_079506.3	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11	321						CUL4 RING ubiquitin ligase complex	protein binding										TATAAGCTCCCAAATCCTGTT	0.522000													18	24					0	0	1	0	0
CNR1	0	broad.mit.edu	37	6	88853988	88853988	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:88853988G>A	ENST00000537554.1	-	2	4568	c.1006C>T	c.(1006-1008)Cgc>Tgc	p.R336C	CNR1_ENST00000468898.1_Missense_Mutation_p.R303C|CNR1_ENST00000428600.2_Missense_Mutation_p.R336C|CNR1_ENST00000549890.1_Missense_Mutation_p.R336C|CNR1_ENST00000369499.2_Missense_Mutation_p.R336C|CNR1_ENST00000369501.2_Missense_Mutation_p.R336C|CNR1_ENST00000549716.1_Missense_Mutation_p.R275C|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000535130.1_Missense_Mutation_p.R336C	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	336					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	ATGTCCATGCGGGCTTGGTCT	0.567000													22	30					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	241033418	241033418	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:241033418G>A	ENST00000366565.1	-	7	768	c.385_splice	c.e7-1	p.A129_splice	RGS7_ENST00000446183.2_Splice_Site_p.A45_splice|RGS7_ENST00000331110.7_Splice_Site_p.A103_splice|RGS7_ENST00000366563.1_Splice_Site_p.A129_splice|RGS7_ENST00000348120.2_Splice_Site_p.A76_splice|RGS7_ENST00000401882.1_Splice_Site_p.A76_splice|RGS7_ENST00000366564.1_Splice_Site_p.A129_splice|RGS7_ENST00000366562.4_Splice_Site_p.A129_splice|RGS7_ENST00000407727.1_Splice_Site_p.A129_splice	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	129					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			AGAGGTAAACGGCTGAAAAAA	0.413000													29	41					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240111765	240111765	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:240111765C>T	ENST00000345617.3	-	4	894	c.103G>A	c.(103-105)Gcc>Acc	p.A35T	HDAC4_ENST00000541256.1_Missense_Mutation_p.A4T	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	35					B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		AGCGCCGTGGCCACATCCACT	0.672000													9	12					0	0	1	0	0
CXXC5	51523	broad.mit.edu	37	5	139060706	139060706	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:139060706G>A	ENST00000302517.3	+	2	1312	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	CXXC5_ENST00000515038.1_3'UTR|CXXC5_ENST00000511048.1_Missense_Mutation_p.E200K	NM_016463.7	NP_057547.5	Q7LFL8	CXXC5_HUMAN	CXXC finger protein 5	200					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCAGGTGCCGAAGCCCTCAA	0.637000													8	7					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22192252	22192252	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:22192252G>A	ENST00000374695.3	-	34	4351	c.4272C>T	c.(4270-4272)ggC>ggT	p.G1424G		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1424	Laminin IV type A 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGCCCTGTGGGCCTGCTGTGT	0.622000													37	102					0	0	1	0	0
MRGPRE	116534	broad.mit.edu	37	11	3249706	3249706	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3249706G>A	ENST00000389832.5	-	2	630	c.324C>T	c.(322-324)atC>atT	p.I108I	AC109309.4_ENST00000418995.2_RNA|MRGPRE_ENST00000436689.2_Silent_p.I107I			Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	107						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCAGGCCCACGATGTAGCAGA	0.682000													7	17					0	0	1	0	0
ANGEL2	90806	broad.mit.edu	37	1	213181729	213181729	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:213181729A>T	ENST00000366962.3	-	3	619	c.465T>A	c.(463-465)gaT>gaA	p.D155E	ANGEL2_ENST00000535388.1_5'UTR|ANGEL2_ENST00000540642.1_Missense_Mutation_p.D29E|ANGEL2_ENST00000360506.2_5'UTR|ANGEL2_ENST00000544555.1_5'UTR	NM_144567.3	NP_653168.2	Q5VTE6	ANGE2_HUMAN	angel homolog 2 (Drosophila)	155										central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(1)	24				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		CACATTTGGGATCAACATTTT	0.333000													4	76					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47951338	47951338	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47951338G>A	ENST00000236877.6	-	4	1886	c.1491C>T	c.(1489-1491)gaC>gaT	p.D497D	SLC8A2_ENST00000542837.1_Silent_p.D253D|SLC8A2_ENST00000539381.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	497					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		GCCCGCCGCCGTCCGGCTCGA	0.687000													6	5					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49691866	49691866	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49691866C>T	ENST00000296452.4	+	5	4991	c.4877C>T	c.(4876-4878)cCc>cTc	p.P1626L		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1626					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCAGATGGGCCCCTGGCACTA	0.652000													11	10					0	0	1	0	0
KIAA0753	9851	broad.mit.edu	37	17	6528142	6528142	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:6528142C>T	ENST00000361413.3	-	4	1116	c.758G>A	c.(757-759)cGa>cAa	p.R253Q	KIAA0753_ENST00000572370.1_5'UTR|KIAA0753_ENST00000542606.1_Intron	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	253						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		GATACGGATTCGACGTTCTTC	0.428000													4	6					0	0	1	0	0
DRD4	1815	broad.mit.edu	37	11	640482	640482	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:640482G>A	ENST00000176183.5	+	4	1151	c.1139G>A	c.(1138-1140)cGg>cAg	p.R380Q		NM_000797.3	NP_000788.2	P21917	DRD4_HUMAN	dopamine receptor D4	428					activation of MAPK activity|adult locomotory behavior|arachidonic acid secretion|behavioral fear response|behavioral response to cocaine|behavioral response to ethanol|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of protein secretion|positive regulation of sodium:hydrogen antiporter activity|regulation of dopamine metabolic process|regulation of inhibitory postsynaptic membrane potential|response to amphetamine|response to histamine|social behavior	integral to plasma membrane	dopamine D4 receptor activity|drug binding|potassium channel regulator activity|SH3 domain binding			NS(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.36e-28)|Epithelial(43;2.59e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Apomorphine(DB00714)|Clozapine(DB00363)|Olanzapine(DB00334)|Pramipexole(DB00413)|Promazine(DB00420)|Propiomazine(DB00777)|Ropinirole(DB00268)|Thiethylperazine(DB00372)|Ziprasidone(DB00246)	GTGCCCCCGCGGCTGGTCAGC	0.672000													19	27					0	0	1	0	0
ST3GAL2	6483	broad.mit.edu	37	16	70422350	70422350	+	Silent	SNP	G	G	A	rs150069651		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:70422350G>A	ENST00000393640.4	-	3	2740	c.633C>T	c.(631-633)aaC>aaT	p.N211N	ST3GAL2_ENST00000342907.2_Silent_p.N211N|RP11-529K1.4_ENST00000566960.1_RNA			Q16842	SIA4B_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	211					amino sugar metabolic process	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	11		Ovarian(137;0.0694)				CGAAGCTGACGTTGGCGGGCA	0.597000													39	52					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48619871	48619871	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:48619871C>A	ENST00000435803.1	+	56	14430	c.14406C>A	c.(14404-14406)taC>taA	p.Y4802*	ABCA13_ENST00000544596.1_Nonsense_Mutation_p.Y532*	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4802	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCATTGGCTACTGTCCCCAGC	0.567000													11	8					2.80697e-09	2.97546e-09	1	1	0
NEK4	6787	broad.mit.edu	37	3	52785948	52785948	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52785948C>A	ENST00000233027.5	-	7	1570	c.1368_splice	c.e7+1	p.Q456_splice	NEK4_ENST00000535191.1_Splice_Site_p.Q367_splice|NEK4_ENST00000383721.4_Splice_Site_p.Q456_splice	NM_001193533.1|NM_003157.4	NP_001180462.1|NP_003148.2	P51957	NEK4_HUMAN	NIMA-related kinase 4	456			Q -> E (in dbSNP:rs56019351).		cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(10)	26				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TATCACTCACCTGGTCCTTTG	0.428000													39	93					7.04047e-22	7.82589e-22	1	1	0
FAM57A	79850	broad.mit.edu	37	17	641198	641198	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:641198T>C	ENST00000308278.8	+	3	555	c.319T>C	c.(319-321)Tcc>Ccc	p.S107P	FAM57A_ENST00000572018.1_Intron|FAM57A_ENST00000301324.8_Missense_Mutation_p.S107P	NM_024792.1	NP_079068.1	Q8TBR7	FA57A_HUMAN	family with sequence similarity 57, member A	107	TLC.					integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)|urinary_tract(2)	10				UCEC - Uterine corpus endometrioid carcinoma (25;0.0217)		CCGTGCGCCCTCCCTCACTCT	0.512000													56	95					0	0	1	0	0
ACAT1	38	broad.mit.edu	37	11	108014721	108014721	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:108014721G>A	ENST00000265838.4	+	10	1043	c.952G>A	c.(952-954)Gct>Act	p.A318T		NM_000019.3	NP_000010.1	P24752	THIL_HUMAN	acetyl-CoA acetyltransferase 1	318					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(3)|prostate(2)	10		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)	ATTTGCTGACGCTGCTGTAGA	0.398000													29	45					0	0	1	0	0
FTMT	94033	broad.mit.edu	37	5	121187725	121187725	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:121187725C>T	ENST00000321339.1	+	1	76	c.67C>T	c.(67-69)Cgc>Tgc	p.R23C		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial	23					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity	p.R23C(1)		NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GCGCCCGGTGCGCTGCTGCTT	0.731000													13	20					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12950183	12950183	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:12950183G>A	ENST00000276297.4	-	13	4087	c.3678C>T	c.(3676-3678)gcC>gcT	p.A1226A	DLC1_ENST00000512044.2_Silent_p.A823A|DLC1_ENST00000520226.1_Silent_p.A715A|DLC1_ENST00000510318.1_5'UTR|DLC1_ENST00000358919.2_Silent_p.A789A	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	1226	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CTAAGCACACGGCCAGGTTGG	0.562000													8	18					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135073364	135073364	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:135073364C>T	ENST00000393229.3	+	3	1001	c.225C>T	c.(223-225)taC>taT	p.Y75Y	NTNG2_ENST00000360670.3_Silent_p.Y75Y|NTNG2_ENST00000393228.4_Silent_p.Y75Y|NTNG2_ENST00000372179.3_Silent_p.Y75Y	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	75	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		AGAATCCCTACCTATGCAGCA	0.662000													12	15					0	0	1	0	0
SERPINE2	5270	broad.mit.edu	37	2	224866369	224866369	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:224866369G>A	ENST00000409840.3	-	3	909	c.249C>T	c.(247-249)taC>taT	p.Y83Y	SERPINE2_ENST00000258405.4_Silent_p.Y83Y|SERPINE2_ENST00000409304.1_Silent_p.Y83Y|SERPINE2_ENST00000447280.2_Silent_p.Y95Y			P07093	GDN_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	83					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)	17		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		CATTTACGCCGTATCTCATCA	0.567000													15	24					0	0	1	0	0
RP11-64J4.2	0	broad.mit.edu	37	17	3214437	3214437	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3214437G>A	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							AAGGGCATTGGCATCCTCAAC	0.562000													18	66					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96964107	96964107	+	Missense_Mutation	SNP	C	C	A	rs140158261		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:96964107C>A	ENST00000323853.5	-	9	1111	c.1034G>T	c.(1033-1035)aGg>aTg	p.R345M	SNRNP200_ENST00000349783.5_Missense_Mutation_p.R345M	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	345						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						TCCCATAATCCTTTCCTTTTC	0.463000													11	50					1.58986e-06	1.65464e-06	1	1	0
MUC17	140453	broad.mit.edu	37	7	100679721	100679721	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100679721C>T	ENST00000306151.4	+	3	5088	c.5024C>T	c.(5023-5025)gCt>gTt	p.A1675V		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1675	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTACACCTGCTGAAGGTACC	0.493000													90	144					0	0	1	0	0
SLC25A41	284427	broad.mit.edu	37	19	6427257	6427257	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6427257A>G	ENST00000321510.6	-	6	865	c.797T>C	c.(796-798)cTc>cCc	p.L266P		NM_173637.3	NP_775908.2	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	266					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			large_intestine(1)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	6						GAAGCACTGGAGCATCTGCAA	0.627000													4	10					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120009362	120009362	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:120009362C>T	ENST00000371311.3	-	1	417	c.163G>A	c.(163-165)Gca>Aca	p.A55T		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	55										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						ACGGGCCCTGCGACTCCGACC	0.741000													31	7					0	0	1	0	0
ZBTB48	3104	broad.mit.edu	37	1	6640742	6640742	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:6640742T>C	ENST00000377674.4	+	2	231	c.73T>C	c.(73-75)Tac>Cac	p.Y25H		NM_001278647.1|NM_001278648.1|NM_005341.2	NP_001265576.1|NP_001265577.1|NP_005332.1	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	25						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		GAAGGGCCAGTACTGCGACGC	0.607000													12	17					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47587613	47587613	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47587613G>A	ENST00000253048.5	-	9	1244	c.1207C>T	c.(1207-1209)Cgc>Tgc	p.R403C	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	403							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CAGGTGCAGCGCCCTTCCACG	0.592000													9	17					0	0	1	0	0
CXorf61	203413	broad.mit.edu	37	X	115593953	115593953	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:115593953C>T	ENST00000371894.4	-	1	211	c.65G>A	c.(64-66)cGc>cAc	p.R22H		NM_001017978.2	NP_001017978.1	Q5H943	KKLC1_HUMAN	chromosome X open reading frame 61	22						integral to membrane|plasma membrane				breast(1)|large_intestine(3)|lung(8)	12						CTGAAAGCGGCGATATTTCCA	0.428000													28	2					0	0	1	0	0
TBXA2R	0	broad.mit.edu	37	19	3600087	3600087	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3600087C>T	ENST00000375190.4	-	2	939	c.546G>A	c.(544-546)tgG>tgA	p.W182*	TBXA2R_ENST00000587717.1_5'UTR|TBXA2R_ENST00000411851.3_Nonsense_Mutation_p.W182*|TBXA2R_ENST00000589966.1_Intron	NM_001060.5|NM_201636.2	NP_001051.1|NP_963998.2	P21731	TA2R_HUMAN	thromboxane A2 receptor	182					platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	TCAGGAAGCACCAGGACCCCG	0.721000													7	20					0	0	1	0	0
SCRN3	79634	broad.mit.edu	37	2	175265862	175265862	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:175265862T>C	ENST00000272732.6	+	4	568	c.486T>C	c.(484-486)aaT>aaC	p.N162N	SCRN3_ENST00000409673.3_Silent_p.N155N	NM_001193528.1|NM_024583.4	NP_001180457.1|NP_078859.2	Q0VDG4	SCRN3_HUMAN	secernin 3	162					proteolysis		dipeptidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			CTGATAGGAATGAAGCCTGGA	0.388000													17	32					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47912426	47912426	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47912426T>C	ENST00000426837.2	-	15	6258	c.6171A>G	c.(6169-6171)aaA>aaG	p.K2057K	MAP4_ENST00000420772.2_Silent_p.K643K|MAP4_ENST00000395734.3_Silent_p.K912K|MAP4_ENST00000264724.11_Silent_p.K647K|MAP4_ENST00000383737.4_Silent_p.K640K|MAP4_ENST00000360240.6_Silent_p.K912K|MAP4_ENST00000441748.2_Silent_p.K64K			P27816	MAP4_HUMAN	microtubule-associated protein 4	912					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGGAGCTGGGTTTGGCCGAGG	0.622000													14	50					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152676013	152676013	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152676013G>A	ENST00000367255.5	-	67	11308	c.10707C>T	c.(10705-10707)gaC>gaT	p.D3569D	SYNE1_ENST00000448038.1_Silent_p.D3576D|SYNE1_ENST00000341594.5_Silent_p.D3540D|SYNE1_ENST00000423061.1_Silent_p.D3576D|SYNE1_ENST00000265368.4_Silent_p.D3569D	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3569					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTAAAGCCCGGTCCTCTGCCT	0.547000										HNSCC(10;0.0054)			34	39					0	0	1	0	0
PTPN7	5778	broad.mit.edu	37	1	202127379	202127379	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:202127379A>G	ENST00000309017.3	-	3	1261	c.488T>C	c.(487-489)gTa>gCa	p.V163A	PTPN7_ENST00000492977.1_5'UTR|PTPN7_ENST00000367279.4_Missense_Mutation_p.V97A|PTPN7_ENST00000544762.1_5'UTR|PTPN7_ENST00000308986.5_Missense_Mutation_p.V58A|PTPN7_ENST00000543735.1_Intron	NM_001199797.1|NM_002832.3	NP_001186726.1|NP_002823.3	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type 7	58	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|soft_tissue(1)|urinary_tract(1)	13						GATGGGTTCTACGGCCCCCAG	0.617000													3	20					0	0	1	0	0
IGKV1D-13	0	broad.mit.edu	37	2	90193290	90193290	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:90193290G>A	ENST00000390275.2	+	0	397																											GATCTATGATGCCTCCAGTTT	0.527000													8	129					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67269354	67269354	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67269354C>T	ENST00000356404.3	-	5	844	c.619G>A	c.(619-621)Gag>Aag	p.E207K	PITPNM1_ENST00000436757.2_Missense_Mutation_p.E207K|PITPNM1_ENST00000534749.1_Missense_Mutation_p.E207K	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	207					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						ATGAACTGCTCGATCTTGGCT	0.597000													11	17					0	0	1	0	0
NPEPL1	79716	broad.mit.edu	37	20	57269496	57269496	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:57269496G>A	ENST00000356091.6	+	3	643	c.355G>A	c.(355-357)Gag>Aag	p.E119K	STX16-NPEPL1_ENST00000530122.1_3'UTR|NPEPL1_ENST00000525817.1_Missense_Mutation_p.E71K|NPEPL1_ENST00000525967.1_Missense_Mutation_p.E91K	NM_024663.3	NP_078939.3	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	119					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity	p.E119K(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			CGAGCAGCCGGAGGTCTTTGC	0.667000													25	52					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45905186	45905186	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:45905186C>T	ENST00000311275.7	-	11	1545	c.1292G>A	c.(1291-1293)cGc>cAc	p.R431H	ZMYND8_ENST00000352431.2_Missense_Mutation_p.R451H|ZMYND8_ENST00000540497.1_Missense_Mutation_p.R426H|ZMYND8_ENST00000458360.2_Missense_Mutation_p.R426H|ZMYND8_ENST00000396281.4_Missense_Mutation_p.R431H|ZMYND8_ENST00000262975.4_Missense_Mutation_p.R431H|ZMYND8_ENST00000536340.1_Missense_Mutation_p.R458H|ZMYND8_ENST00000471951.2_Missense_Mutation_p.R451H|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000355972.4_Missense_Mutation_p.R431H|ZMYND8_ENST00000372023.3_Missense_Mutation_p.R426H|ZMYND8_ENST00000360911.3_Missense_Mutation_p.R426H|ZMYND8_ENST00000461685.1_Missense_Mutation_p.R451H|ZMYND8_ENST00000446994.2_Missense_Mutation_p.R368H			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	431							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			CATGGGGGAGCGCGGCATATC	0.597000													25	20					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166827379	166827379	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:166827379C>T	ENST00000510118.1	-	22	2394	c.2054G>A	c.(2053-2055)cGc>cAc	p.R685H	RPS6KA2_ENST00000481261.2_Missense_Mutation_p.R571H|RPS6KA2_ENST00000405189.3_Missense_Mutation_p.R571H|RPS6KA2_ENST00000509742.1_5'UTR|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.R668H|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.R660H			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	660					axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		CGCCGTCAGGCGCTGATGAGG	0.587000													12	15					0	0	1	0	0
MLH3	27030	broad.mit.edu	37	14	75515153	75515153	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:75515153C>A	ENST00000355774.2	-	2	1421	c.1206G>T	c.(1204-1206)gaG>gaT	p.E402D	MLH3_ENST00000556740.1_Missense_Mutation_p.E402D|MLH3_ENST00000556257.1_Missense_Mutation_p.E402D|MLH3_ENST00000380968.2_5'UTR|MLH3_ENST00000238662.7_Missense_Mutation_p.E402D	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	402					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		AATTAAACATCTCATAGGAAT	0.353000								Mismatch excision repair (MMR)					15	36					6.72482e-11	7.20828e-11	1	1	0
DLD	1738	broad.mit.edu	37	7	107546746	107546746	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:107546746C>T	ENST00000205402.5	+	8	898	c.617C>T	c.(616-618)gCt>gTt	p.A206V	DLD_ENST00000537148.1_Missense_Mutation_p.A107V|DLD_ENST00000437604.2_Missense_Mutation_p.A158V|DLD_ENST00000440410.1_Missense_Mutation_p.A183V	NM_000108.3	NP_000099.2	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase	206					branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(10)|prostate(1)	20					NADH(DB00157)	TCTACAGGTGCTTTATCTTTA	0.333000													8	24					0	0	1	0	0
RPL23AP53	0	broad.mit.edu	37	8	163709	163709	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:163709G>A	ENST00000606975.1	-	0	212																											TTTCGGTGCCGTCTTGTGAAA	0.408000													4	19					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27503740	27503740	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:27503740G>A	ENST00000356183.4	-	19	3085	c.3070C>T	c.(3070-3072)Cgc>Tgc	p.R1024C	GTF3C1_ENST00000561623.1_Missense_Mutation_p.R1024C	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1024						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						ACATAGAGGCGCCTCTCGAAG	0.532000													16	34					0	0	1	0	0
ZNF259	8882	broad.mit.edu	37	11	116657731	116657731	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:116657731C>T	ENST00000227322.3	-	3	437	c.378G>A	c.(376-378)agG>agA	p.R126R		NM_003904.3	NP_003895.1	O75312	ZPR1_HUMAN	zinc finger protein 259	126					cell proliferation|signal transduction	cytoplasm|nucleolus				breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		GCTCAGGAATCCTTGTGGCAG	0.438000													62	77					0	0	1	0	0
DLG1	1739	broad.mit.edu	37	3	196921376	196921376	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:196921376C>T	ENST00000346964.2	-	5	592	c.403G>A	c.(403-405)Gtt>Att	p.V135I	DLG1_ENST00000357674.4_Missense_Mutation_p.V135I|DLG1_ENST00000485409.1_5'UTR|DLG1_ENST00000314062.3_Missense_Mutation_p.V135I|DLG1_ENST00000419354.1_Missense_Mutation_p.V135I|DLG1_ENST00000450955.1_Missense_Mutation_p.V135I|DLG1_ENST00000448528.2_Missense_Mutation_p.V135I|DLG1_ENST00000422288.1_Missense_Mutation_p.V135I|DLG1_ENST00000392382.2_Missense_Mutation_p.V135I	NM_004087.2	NP_004078.2	Q12959	DLG1_HUMAN	discs, large homolog 1 (Drosophila)	135					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GAGACATGAACCAATTCTGGA	0.343000													17	25					0	0	1	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130387534	130387534	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:130387534T>C	ENST00000529410.1	+	13	1380	c.901T>C	c.(901-903)Tat>Cat	p.Y301H	L3MBTL3_ENST00000368139.2_Missense_Mutation_p.Y276H|L3MBTL3_ENST00000368136.2_Missense_Mutation_p.Y301H|L3MBTL3_ENST00000361794.2_Missense_Mutation_p.Y301H|L3MBTL3_ENST00000533560.1_Missense_Mutation_p.Y276H|L3MBTL3_ENST00000526019.1_Missense_Mutation_p.Y276H			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	301					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		CTTTGATGGGTATTCTGATTG	0.388000													30	45					0	0	1	0	0
ADSS	159	broad.mit.edu	37	1	244572920	244572920	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:244572920T>C	ENST00000366535.3	-	13	1655	c.1339A>G	c.(1339-1341)Aaa>Gaa	p.K447E		NM_001126.3	NP_001117.2	P30520	PURA2_HUMAN	adenylosuccinate synthase	447					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	TCTCTGGATTTACCAACACCA	0.358000													30	53					0	0	1	0	0
DDX58	23586	broad.mit.edu	37	9	32466305	32466305	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:32466305C>A	ENST00000379882.1	-	15	2342	c.2185G>T	c.(2185-2187)Gca>Tca	p.A729S	DDX58_ENST00000379868.1_Missense_Mutation_p.A571S|DDX58_ENST00000542096.1_Missense_Mutation_p.A703S|DDX58_ENST00000379883.2_Missense_Mutation_p.A774S			O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	774	Helicase C-terminal.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		CTAAATACTGCTTCGTCCCAT	0.353000													46	73					4.16331e-43	4.68058e-43	1	1	0
WDR36	134430	broad.mit.edu	37	5	110446962	110446962	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:110446962C>T	ENST00000506538.2	+	15	2442	c.1869C>T	c.(1867-1869)ggC>ggT	p.G623G	WDR36_ENST00000505303.1_Silent_p.G567G|WDR36_ENST00000513710.2_Silent_p.G623G	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	623					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GACACCAAGGCCAAATAAATG	0.368000													40	65					0	0	1	0	0
RBMS1	5937	broad.mit.edu	37	2	161137851	161137851	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:161137851G>A	ENST00000348849.3	-	10	1355	c.925C>T	c.(925-927)Cct>Tct	p.P309S	RBMS1_ENST00000409972.1_Missense_Mutation_p.P273S|RBMS1_ENST00000474820.1_5'UTR|RBMS1_ENST00000409289.2_Missense_Mutation_p.P273S|RBMS1_ENST00000392753.3_Missense_Mutation_p.P322S|RBMS1_ENST00000409075.1_Missense_Mutation_p.P273S	NM_002897.4|NM_016836.3	NP_002888.1|NP_058520.1	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting protein 1	309					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding		PLA2R1/RBMS1(2)								TATGGTTGAGGTTGCATCCAC	0.313000													29	45					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132535161	132535161	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:132535161G>A	ENST00000265342.7	-	16	2404	c.2155C>T	c.(2155-2157)Cgg>Tgg	p.R719W	CTB-49A3.2_ENST00000509051.1_RNA	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	719						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATCTCGCCCCGCACTGTGATC	0.557000													22	25					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104140354	104140354	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:104140354C>T	ENST00000369983.3	+	38	5341	c.5081C>T	c.(5080-5082)cCc>cTc	p.P1694L		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1694					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GGAGGCGGCCCCTCGGCCCTC	0.577000													85	136					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86518655	86518655	+	Missense_Mutation	SNP	G	G	A	rs139609439	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:86518655G>A	ENST00000297814.2	-	4	921	c.778C>T	c.(778-780)Cgg>Tgg	p.R260W	KIF27_ENST00000413982.1_Missense_Mutation_p.R260W|KIF27_ENST00000334204.2_Missense_Mutation_p.R260W	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	260	Kinesin-motor.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TCTTTGAACCGTTCACCAGTA	0.433000													22	48					0	0	1	0	0
RAB35	11021	broad.mit.edu	37	12	120534940	120534940	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:120534940G>A	ENST00000432953.2	-	2	298	c.110C>T	c.(109-111)tCt>tTt	p.S37F	RAB35_ENST00000534951.1_3'UTR|RAB35_ENST00000229340.5_3'UTR			Q15286	RAB35_HUMAN	RAB35, member RAS oncogene family	92					cytokinesis|endosome transport|protein transport|small GTPase mediated signal transduction	cell projection membrane|clathrin-coated endocytic vesicle|coated pit|endosome|intercellular bridge|melanosome	GTP binding|GTPase activity|phosphatidylinositol-4,5-bisphosphate binding			endometrium(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.248)		AACATGGAGAGAATTCTTTAA	0.602000													5	9					0	0	1	0	0
DPP8	54878	broad.mit.edu	37	15	65793039	65793039	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:65793039C>T	ENST00000341861.5	-	4	2079	c.499G>A	c.(499-501)Gct>Act	p.A167T	DPP8_ENST00000559233.1_Missense_Mutation_p.A167T|DPP8_ENST00000339244.5_Missense_Mutation_p.A167T|DPP8_ENST00000358939.4_Missense_Mutation_p.A151T|DPP8_ENST00000321147.6_Missense_Mutation_p.A167T|DPP8_ENST00000321118.7_Missense_Mutation_p.A167T|DPP8_ENST00000300141.6_Missense_Mutation_p.A151T	NM_197960.2	NP_932064.1	Q6V1X1	DPP8_HUMAN	dipeptidyl-peptidase 8	167					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(11)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TCGTAAGAAGCAATTCCGACT	0.408000													43	65					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65181514	65181514	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:65181514G>A	ENST00000310045.7	-	2	1835	c.362C>T	c.(361-363)gCt>gTt	p.A121V		NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	111						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				AGCAAAATCAGCATGCTTTGG	0.413000													42	47					0	0	1	0	0
POU3F4	5456	broad.mit.edu	37	X	82764214	82764214	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:82764214G>T	ENST00000373200.2	+	1	946	c.882G>T	c.(880-882)gaG>gaT	p.E294D	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	294					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						GCGTACTGGAGACGCATTTCC	0.602000													4	1					0.00024832	0.000253518	1	1	0
LIMD1	8994	broad.mit.edu	37	3	45715854	45715854	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:45715854G>A	ENST00000273317.4	+	7	1865	c.1844G>A	c.(1843-1845)cGt>cAt	p.R615H		NM_014240.2	NP_055055.1	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	615	LIM zinc-binding 3.|Necessary for nuclear localization.				cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		GAGACCATCCGTGTCGTGTCC	0.582000													12	13					0	0	1	0	0
PDHA1	5160	broad.mit.edu	37	X	19369472	19369472	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:19369472G>A	ENST00000379806.5	+	5	624	c.479G>A	c.(478-480)gGc>gAc	p.G160D	PDHA1_ENST00000540249.1_Missense_Mutation_p.G122D|PDHA1_ENST00000545074.1_Missense_Mutation_p.G129D|PDHA1_ENST00000422285.2_Missense_Mutation_p.G122D|PDHA1_ENST00000379805.3_Missense_Mutation_p.G122D	NM_001173454.1	NP_001166925.1	P08559	ODPA_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 1	122					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)	18	Hepatocellular(33;0.183)				NADH(DB00157)	CGGGCTCACGGCTTTACTTTC	0.507000													5	73					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64594813	64594813	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64594813C>T	ENST00000342711.5	-	33	4207	c.4208G>A	c.(4207-4209)cGc>cAc	p.R1403H		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1403					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity	p.R1403H(1)		central_nervous_system(1)|lung(3)	4						GCTCTTGGTGCGGAACAGCTG	0.652000													34	54					0	0	1	0	0
GABRB1	2560	broad.mit.edu	37	4	47427967	47427967	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:47427967T>C	ENST00000295454.3	+	9	1649	c.1357T>C	c.(1357-1359)Tcc>Ccc	p.S453P	GABRB1_ENST00000538619.1_Missense_Mutation_p.S383P	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	453					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGACAAGTGGTCCCGAATGTT	0.488000													11	146					0	0	1	0	0
SGK1	6446	broad.mit.edu	37	6	134491490	134491490	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:134491490G>A	ENST00000367858.5	-	14	2094	c.1497C>T	c.(1495-1497)agC>agT	p.S499S	SGK1_ENST00000475719.2_Silent_p.S360S|SGK1_ENST00000413996.3_Silent_p.S418S|SGK1_ENST00000528577.1_Silent_p.S432S|SGK1_ENST00000367857.5_Silent_p.S394S|SGK1_ENST00000237305.7_Silent_p.S404S	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	404					apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		TGACGAGGACGCTGTCAGGGG	0.587000													13	29					0	0	1	0	0
EPHB6	0	broad.mit.edu	37	7	142562446	142562446	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142562446C>T	ENST00000392957.2	+	7	1675	c.888C>T	c.(886-888)gtC>gtT	p.V296V	EPHB6_ENST00000442129.1_Silent_p.V296V|EPHB6_ENST00000411471.2_Silent_p.V19V	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	296	Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					TGGTAGCTGTCGGGGGCTGCC	0.662000													22	42					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29996844	29996844	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:29996844C>T	ENST00000308893.4	+	14	2776	c.1733C>T	c.(1732-1734)gCc>gTc	p.A578V	TAOK2_ENST00000543033.1_Missense_Mutation_p.A578V|TAOK2_ENST00000416441.2_Missense_Mutation_p.A405V|TAOK2_ENST00000279394.3_Missense_Mutation_p.A578V	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	578					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						GAGCTGGCTGCCCTGCTGGAG	0.637000													10	14					0	0	1	0	0
KNCN	148930	broad.mit.edu	37	1	47014926	47014926	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47014926G>A	ENST00000481882.2	-	3	545	c.234C>T	c.(232-234)atC>atT	p.I78I	KNCN_ENST00000396314.3_Silent_p.I55I|MKNK1-AS1_ENST00000602433.1_RNA|KNCN_ENST00000524908.1_5'UTR			A6PVL3	KNCN_HUMAN	kinocilin	78						integral to membrane		p.I78M(1)		central_nervous_system(1)|endometrium(1)|lung(1)|ovary(1)	4	Acute lymphoblastic leukemia(166;0.155)					GATGGGGATGGATTCTTAGGC	0.527000													4	19					0	0	1	0	0
CAND2	23066	broad.mit.edu	37	3	12869094	12869094	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:12869094C>T	ENST00000456430.2	+	13	3407	c.3366C>T	c.(3364-3366)taC>taT	p.Y1122Y	CAND2_ENST00000295989.5_Silent_p.Y1005Y	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	1122					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						AGGACCACTACGACATCCGGG	0.562000													10	33					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47228829	47228829	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47228829C>T	ENST00000391910.3	-	10	1796	c.1346G>A	c.(1345-1347)cGt>cAt	p.R449H	STRN4_ENST00000263280.6_Missense_Mutation_p.R442H|STRN4_ENST00000594357.2_5'UTR|STRN4_ENST00000539396.1_Missense_Mutation_p.R323H			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	442						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		GGCCAGGGAACGAATGCCGTC	0.612000													9	25					0	0	1	0	0
DNAJA1	3301	broad.mit.edu	37	9	33029903	33029903	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:33029903C>A	ENST00000330899.4	+	4	514	c.331C>A	c.(331-333)Ctc>Atc	p.L111I	DNAJA1_ENST00000544625.1_5'UTR|DNAJA1_ENST00000495015.1_Intron	NM_001539.2	NP_001530.1	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	111					protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding			large_intestine(2)|ovary(1)|skin(3)	6			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		TGTACATCAGCTCTCAGTAAC	0.343000													19	36					3.51602e-12	3.7986e-12	1	1	0
SVOPL	136306	broad.mit.edu	37	7	138314816	138314816	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:138314816T>C	ENST00000421622.1	-	6	689	c.481A>G	c.(481-483)Aca>Gca	p.T161A	SVOPL_ENST00000288513.5_Missense_Mutation_p.T129A|SVOPL_ENST00000419765.3_Missense_Mutation_p.T281A|SVOPL_ENST00000436657.1_Missense_Mutation_p.T129A			Q8N434	SVOPL_HUMAN	SVOP-like	281						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						ATCTGTAATGTGGTCCGTAAA	0.373000													33	41					0	0	1	0	0
ATF3	467	broad.mit.edu	37	1	212788505	212788505	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:212788505G>A	ENST00000341491.4	+	2	407	c.142G>A	c.(142-144)Gcc>Acc	p.A48T	ATF3_ENST00000492118.1_Intron|ATF3_ENST00000366985.1_5'UTR|ATF3_ENST00000366983.1_Missense_Mutation_p.A48T|ATF3_ENST00000366987.2_Missense_Mutation_p.A48T|ATF3_ENST00000336937.4_Missense_Mutation_p.A19T	NM_001040619.2|NM_001206488.2|NM_001674.3	NP_001035709.1|NP_001193417.2|NP_001665.1	P18847	ATF3_HUMAN	activating transcription factor 3	48						nucleolus	identical protein binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6				OV - Ovarian serous cystadenocarcinoma(81;0.00628)|all cancers(67;0.0097)|GBM - Glioblastoma multiforme(131;0.0388)|Epithelial(68;0.0933)		GCTGAGGTTTGCCATCCAGAA	0.572000													24	32					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170124	207170124	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:207170124G>A	ENST00000374423.3	+	5	1258	c.872G>A	c.(871-873)cGc>cAc	p.R291H		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	291							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TTCCATGAACGCATGGGTACT	0.358000													3	24					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3628288	3628288	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3628288C>T	ENST00000325418.4	+	1	1078	c.1059C>T	c.(1057-1059)tcC>tcT	p.S353S	ITGAE_ENST00000263087.4_Intron|ITGAE_ENST00000571185.1_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	353					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										TCCTCCATTCCCACCGCTTTA	0.517000													14	28					0	0	1	0	0
RXFP4	339403	broad.mit.edu	37	1	155912363	155912363	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155912363C>T	ENST00000368318.3	+	1	884	c.863C>T	c.(862-864)aCg>aTg	p.T288M		NM_181885.2	NP_871001.1	Q8TDU9	RL3R2_HUMAN	relaxin/insulin-like family peptide receptor 4	288						integral to membrane|plasma membrane	angiotensin type II receptor activity			endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	13	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					ACTATCCAGACGTATGTCTTC	0.547000													28	47					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19230441	19230441	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19230441C>T	ENST00000263200.10	-	4	610	c.538G>A	c.(538-540)Gca>Aca	p.A180T	CLTCL1_ENST00000353891.5_Missense_Mutation_p.A180T|CLTCL1_ENST00000427926.1_Missense_Mutation_p.A180T	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	180	Globular terminal domain.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					AGCTGCATTGCTCCAACCACA	0.408000			T	?	ALCL								10	16					0	0	1	0	0
ALDH8A1	64577	broad.mit.edu	37	6	135265038	135265038	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:135265038G>A	ENST00000265605.2	-	2	273	c.205C>T	c.(205-207)Cgc>Tgc	p.R69C	ALDH8A1_ENST00000367845.2_Missense_Mutation_p.R69C|ALDH8A1_ENST00000367847.2_Missense_Mutation_p.R69C	NM_022568.3	NP_072090.1	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8 family, member A1	69					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	36	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		ACCCGTGAGCGCTCCTGGGGG	0.592000													18	24					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19168289	19168289	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19168289G>A	ENST00000263200.10	-	31	4930	c.4858C>T	c.(4858-4860)Cgc>Tgc	p.R1620C	CLTCL1_ENST00000353891.5_Missense_Mutation_p.R1563C|CLTCL1_ENST00000427926.1_Missense_Mutation_p.R1620C|CLTCL1_ENST00000442042.2_5'UTR	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1620	Heavy chain arm.|Proximal segment.|Trimerization (By similarity).		R -> H (in dbSNP:rs5748024).	RKQEEHVTEPAPLVFDFDGHE -> PPSKRSM (in Ref. 3; AAB40908/AAB40909).	anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					TCTTGCTTGCGCAGACTCTCC	0.602000			T	?	ALCL								4	55					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78579429	78579429	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:78579429G>A	ENST00000397909.2	+	31	5914	c.5741G>A	c.(5740-5742)cGc>cAc	p.R1914H	NAV3_ENST00000552300.1_3'UTR|NAV3_ENST00000266692.7_Missense_Mutation_p.R1715H|NAV3_ENST00000536525.2_Missense_Mutation_p.R1892H|NAV3_ENST00000228327.6_Missense_Mutation_p.R1892H			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1914						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.R1892H(1)		NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AAAGATGGCCGCAGTGTGAAA	0.343000										HNSCC(70;0.22)			33	59					0	0	1	0	0
APOBEC1	339	broad.mit.edu	37	12	7805382	7805382	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:7805382G>T	ENST00000229304.4	-	3	114	c.94C>A	c.(94-96)Ctt>Att	p.L32I		NM_001644.3	NP_001635.2	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	32					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						TCTTTACGAAGTTCTCTGGGG	0.478000													16	32					1.02788e-11	1.10723e-11	1	1	0
PLCB2	5330	broad.mit.edu	37	15	40590845	40590845	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40590845C>A	ENST00000260402.3	-	10	1164	c.915G>T	c.(913-915)caG>caT	p.Q305H	PLCB2_ENST00000557821.1_Missense_Mutation_p.Q305H|PLCB2_ENST00000456256.2_Missense_Mutation_p.Q305H	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	305					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GCAGCTTGTCCTGGGCCAGCA	0.567000													5	12					0.014758	0.0148771	1	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72055848	72055848	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:72055848A>G	ENST00000555818.1	+	2	1607	c.1259A>G	c.(1258-1260)gAg>gGg	p.E420G	SIPA1L1_ENST00000358550.2_Missense_Mutation_p.E420G|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.E420G	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	420					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TTTCGGAATGAGATAGGTGGA	0.458000													14	22					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104323384	104323384	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:104323384G>A	ENST00000389120.3	+	18	2611	c.2521G>A	c.(2521-2523)Gcc>Acc	p.A841T		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	841					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		AATGGAGGCAGCCCAGCTTGC	0.428000													19	29					0	0	1	0	0
DDR1	780	broad.mit.edu	37	6	30866025	30866025	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30866025C>T	ENST00000324771.8	+	18	2940	c.2392C>T	c.(2392-2394)Cgt>Tgt	p.R798C	DDR1_ENST00000376568.3_Missense_Mutation_p.R798C|DDR1_ENST00000376569.3_Missense_Mutation_p.R761C|DDR1_ENST00000376575.3_Missense_Mutation_p.R804C|DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000376570.4_Missense_Mutation_p.R761C|DDR1_ENST00000452441.1_Missense_Mutation_p.R798C|DDR1_ENST00000361741.4_Intron|DDR1_ENST00000508312.1_Missense_Mutation_p.R779C|DDR1_ENST00000376567.2_Missense_Mutation_p.R761C|DDR1_ENST00000418800.2_Missense_Mutation_p.R761C|DDR1_ENST00000513240.1_Missense_Mutation_p.R804C|DDR1_ENST00000454612.2_Missense_Mutation_p.R761C			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	798	Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	GGACTATTACCGTGTGCAGGG	0.607000													12	13					0	0	1	0	0
TUBBP1	0	broad.mit.edu	37	8	30209889	30209889	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:30209889G>T	ENST00000518096.1	+	0	501																											TGGTACGGAAGGAGGCAGAGA	0.577000													11	12					9.70103e-10	1.03282e-09	1	1	0
DGKD	8527	broad.mit.edu	37	2	234350570	234350570	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:234350570C>A	ENST00000264057.2	+	10	1135	c.1123C>A	c.(1123-1125)Ctg>Atg	p.L375M	DGKD_ENST00000409813.3_Missense_Mutation_p.L331M	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	375	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	ATTCCGGATTCTGGTTTGTGG	0.512000													24	44					3.62531e-18	3.99936e-18	1	1	0
FBN1	2200	broad.mit.edu	37	15	48829912	48829912	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:48829912G>A	ENST00000316623.5	-	7	1087	c.632C>T	c.(631-633)gCc>gTc	p.A211V		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	211	TB 1.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCCGACTGTGGCACAGCAGAG	0.572000													26	43					0	0	1	0	0
PSKH1	5681	broad.mit.edu	37	16	67942830	67942830	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67942830C>T	ENST00000291041.5	+	2	348	c.178C>T	c.(178-180)Cac>Tac	p.H60Y		NM_006742.2	NP_006733.1	P11801	KPSH1_HUMAN	protein serine kinase H1	60						endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|nuclear speck|plasma membrane	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(7)|pancreas(1)	12		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0044)|Epithelial(162;0.0197)|all cancers(182;0.128)		TCAGTATGCACACCCCTGCCC	0.602000													11	8					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135554266	135554266	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:135554266C>T	ENST00000483873.2	+	3	986	c.420_splice	c.e3-1	p.A141_splice	GTF3C4_ENST00000372146.4_Silent_p.G420G			Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	0					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		ATGTCACAGGCCTTCACTCAC	0.468000													12	82					0	0	1	0	0
TNFAIP6	7130	broad.mit.edu	37	2	152220548	152220548	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:152220548C>T	ENST00000243347.3	+	2	261	c.186C>T	c.(184-186)ggC>ggT	p.G62G		NM_007115.3	NP_009046.2	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	62	Link.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.131)		AATTTGAAGGCGGCCATCTCG	0.448000													10	24					0	0	1	0	0
PUS7L	83448	broad.mit.edu	37	12	44124291	44124291	+	Missense_Mutation	SNP	G	G	A	rs139103690		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:44124291G>A	ENST00000416848.2	-	9	2482	c.1994C>T	c.(1993-1995)aCg>aTg	p.T665M	PUS7L_ENST00000431332.3_Missense_Mutation_p.T352M|PUS7L_ENST00000344862.5_Missense_Mutation_p.T665M|PUS7L_ENST00000551923.1_Missense_Mutation_p.T665M	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	665					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		GGAACCTTTCGTTTTGACATC	0.368000													24	39					0	0	1	0	0
DDR2	4921	broad.mit.edu	37	1	162749928	162749928	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:162749928T>C	ENST00000367922.2	+	19	2898	c.2460T>C	c.(2458-2460)tgT>tgC	p.C820C	DDR2_ENST00000367921.3_Silent_p.C820C	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	820	Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			CAGCCATTTGTCCTGACTCTG	0.453000													65	87					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123009994	123009994	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:123009994C>T	ENST00000462833.1	-	18	4505	c.3293G>A	c.(3292-3294)cGg>cAg	p.R1098Q	ADCY5_ENST00000309879.5_Missense_Mutation_p.R748Q|ADCY5_ENST00000491190.1_Missense_Mutation_p.R756Q	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	1098	Guanylate cyclase 2.				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		ATTGAGTAGCCGCAGGCACTC	0.592000													7	7					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2436272	2436272	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:2436272G>A	ENST00000419816.2	+	22	4145	c.3871G>A	c.(3871-3873)Ggg>Agg	p.G1291R	PLCH2_ENST00000378488.3_Missense_Mutation_p.G1255R|PLCH2_ENST00000378483.2_3'UTR|PLCH2_ENST00000378486.3_Missense_Mutation_p.G1291R|PLCH2_ENST00000449969.1_3'UTR			O75038	PLCH2_HUMAN	phospholipase C, eta 2	1291					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GCGGGTGTCGGGGCCAGGGGT	0.687000													5	8					0	0	1	0	0
PIGQ	9091	broad.mit.edu	37	16	624509	624509	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:624509C>T	ENST00000321878.5	+	2	594	c.435C>T	c.(433-435)acC>acT	p.T145T	PIGQ_ENST00000026218.5_Silent_p.T145T|PIGQ_ENST00000409527.2_Silent_p.T145T|PIGQ_ENST00000470411.2_Silent_p.T145T	NM_004204.3	NP_004195.2	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	145					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				ACCTGCCCACCGTCCTGCCCG	0.672000													4	7					0	0	1	0	0
N4BP2	55728	broad.mit.edu	37	4	40108585	40108585	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:40108585G>A	ENST00000261435.6	+	5	1855	c.1439G>A	c.(1438-1440)gGa>gAa	p.G480E		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	480						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						TATATAAATGGACAGTACCAG	0.333000													20	41					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172046812	172046812	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:172046812G>A	ENST00000336824.4	+	12	1424	c.1325G>A	c.(1324-1326)tGt>tAt	p.C442Y	FNDC3B_ENST00000416957.1_Missense_Mutation_p.C442Y|FNDC3B_ENST00000415807.2_Missense_Mutation_p.C442Y	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	442	Fibronectin type-III 2.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ACAAAGCTTTGTCCGGCAATG	0.463000													26	39					0	0	1	0	0
AAK1	22848	broad.mit.edu	37	2	69757829	69757829	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:69757829C>T	ENST00000409085.4	-	7	1042	c.666G>A	c.(664-666)acG>acA	p.T222T	AAK1_ENST00000406297.3_Silent_p.T222T|AAK1_ENST00000409068.1_Silent_p.T222T	NM_014911.3	NP_055726.3	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	222	Protein kinase.					coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						GATAGGACAGCGTTGTGTATC	0.358000													15	38					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26970297	26970297	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26970297C>T	ENST00000528896.2	-	4	355	c.281G>A	c.(280-282)cGt>cAt	p.R94H	KIAA0100_ENST00000544884.1_5'UTR|KIAA0100_ENST00000389003.3_5'UTR	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	94						extracellular region		p.R94H(1)		breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CGTTCTGATACGCACTTCTCC	0.522000													14	53					0	0	1	0	0
SEC23A	10484	broad.mit.edu	37	14	39536389	39536389	+	Silent	SNP	C	C	T	rs140246467	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:39536389C>T	ENST00000537403.1	-	6	1811	c.609G>A	c.(607-609)acG>acA	p.T203T	SEC23A_ENST00000536508.1_Silent_p.T279T|SEC23A_ENST00000545328.2_Silent_p.T376T|SEC23A_ENST00000307712.6_Silent_p.T405T|SEC23A_ENST00000553925.1_5'UTR			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	405					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		TTATTTCTAGCGTACCACCAA	0.328000													35	74					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204397287	204397287	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:204397287C>T	ENST00000367187.3	-	31	5016	c.4460G>A	c.(4459-4461)aGc>aAc	p.S1487N	RP11-739N20.2_ENST00000443515.1_RNA|PIK3C2B_ENST00000424712.2_Missense_Mutation_p.S1459N	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	1487					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			AGGAGCTGGGCTGGTGCCCAT	0.512000													8	7					0	0	1	0	0
MRPL3	11222	broad.mit.edu	37	3	131220553	131220553	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:131220553G>A	ENST00000264995.3	-	2	246	c.99C>T	c.(97-99)caC>caT	p.H33H	MRPL3_ENST00000425847.2_Silent_p.H60H	NM_007208.3	NP_009139.1	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	33					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						AAAGCCAGATGTGTGTTCTAT	0.348000													45	70					0	0	1	0	0
GIF	2694	broad.mit.edu	37	11	59609965	59609965	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:59609965G>A	ENST00000541311.1	-	4	621	c.387C>T	c.(385-387)gcC>gcT	p.A129A	GIF_ENST00000257248.2_Silent_p.A154A			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	154					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						CAAAGCGGACGGCTATCGGCA	0.582000													18	30					0	0	1	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18067098	18067098	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:18067098C>T	ENST00000506618.2	-	1	388	c.308G>A	c.(307-309)aGc>aAc	p.S103N		NM_175886.2	NP_787082.1	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	103					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					TGGGGACCGGCTCTTATCCTT	0.473000													18	95					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99133475	99133475	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99133475C>T	ENST00000370992.4	-	17	1994	c.1883G>A	c.(1882-1884)gGg>gAg	p.G628E	RRP12_ENST00000536831.1_Missense_Mutation_p.G346E|RRP12_ENST00000414986.1_Missense_Mutation_p.G567E|RRP12_ENST00000315563.6_Missense_Mutation_p.G528E	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	628						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TGTGCAGAACCCAGGCAGGAG	0.622000													15	24					0	0	1	0	0
OSBPL11	114885	broad.mit.edu	37	3	125271087	125271087	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:125271087G>A	ENST00000296220.5	-	9	1881	c.1592C>T	c.(1591-1593)gCg>gTg	p.A531V		NM_022776.4	NP_073613.2	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	531					lipid transport		lipid binding	p.A531V(1)		NS(1)|breast(1)|cervix(1)|kidney(2)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	27						CCAGACATGCGCATTTACACA	0.373000													27	49					0	0	1	0	0
SCYL2	55681	broad.mit.edu	37	12	100732507	100732507	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:100732507G>T	ENST00000360820.2	+	18	2784	c.2347G>T	c.(2347-2349)Gga>Tga	p.G783*		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	783	Necessary for interaction with AP2 complex and clathrin, interaction with clathrin is necessary for its targeting to the TGN and endosomal membranes.				endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						TCAGACTTCAGGATTCAACAT	0.423000													36	54					6.90743e-12	7.45315e-12	1	1	0
COCH	1690	broad.mit.edu	37	14	31355287	31355287	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:31355287C>T	ENST00000460581.2	+	9	1456	c.910C>T	c.(910-912)Cgc>Tgc	p.R304C	COCH_ENST00000475087.1_Missense_Mutation_p.R416C|COCH_ENST00000216361.4_Missense_Mutation_p.R416C|COCH_ENST00000396618.3_Missense_Mutation_p.R416C|RP11-829H16.3_ENST00000555108.1_RNA|COCH_ENST00000382493.4_Missense_Mutation_p.R267C			O43405	COCH_HUMAN	cochlin	416	VWFA 1.				sensory perception of sound	proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|pancreas(1)|skin(3)	19	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TTATGATCAGCGCACGGAGTT	0.443000													43	69					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32662409	32662409	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:32662409C>T	ENST00000357033.4	-	11	1377	c.1171G>A	c.(1171-1173)Gcc>Acc	p.A391T	DMD_ENST00000378677.2_Missense_Mutation_p.A387T|DMD_ENST00000288447.4_Missense_Mutation_p.A383T	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	391					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCCTGATGGGCTGTCAAATCC	0.383000													4	55					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27460381	27460381	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27460381A>G	ENST00000264705.4	+	28	4693	c.4531A>G	c.(4531-4533)Att>Gtt	p.I1511V	CAD_ENST00000403525.1_Missense_Mutation_p.I1448V	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1511	DHOase (dihydroorotase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCCCCCCATCATTGACGCCCC	0.607000													12	17					0	0	1	0	0
IFIT2	3433	broad.mit.edu	37	10	91066770	91066770	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:91066770G>A	ENST00000371826.3	+	2	1226	c.1057G>A	c.(1057-1059)Gca>Aca	p.A353T	LIPA_ENST00000371837.1_Intron|LIPA_ENST00000487618.1_Intron	NM_001547.4	NP_001538.4	P09913	IFIT2_HUMAN	interferon-induced protein with tetratricopeptide repeats 2	353					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	12		Colorectal(252;0.0161)				GTATGAAGACGCAGAGTATTA	0.448000													5	47					0	0	1	0	0
AHRR	57491	broad.mit.edu	37	5	424017	424017	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:424017C>T	ENST00000316418.5	+	7	689	c.645C>T	c.(643-645)acC>acT	p.T215T	AHRR_ENST00000512529.1_Silent_p.T61T|AHRR_ENST00000506456.1_Silent_p.T71T|AHRR_ENST00000505113.1_Silent_p.T215T	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	215					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GCACGCCCACCGAGTACTCGG	0.677000													20	25					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1317492	1317492	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:1317492C>T	ENST00000381567.3	-	5	572	c.573G>A	c.(571-573)gaG>gaA	p.E191E	CRLF2_ENST00000467626.1_Intron	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	191	Fibronectin type-III.					extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CATATACATCCTCCATAGCCT	0.517000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								15	41					0	0	1	0	0
TMEM26	219623	broad.mit.edu	37	10	63170404	63170404	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:63170404G>T	ENST00000399298.3	-	6	1151	c.783C>A	c.(781-783)gtC>gtA	p.V261V	TMEM26_ENST00000507507.1_5'UTR	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	261						integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					CTTGTATGAAGACGCTGATTC	0.498000													10	11					7.48243e-07	7.8103e-07	1	1	0
ATP11A	23250	broad.mit.edu	37	13	113512221	113512221	+	Silent	SNP	G	G	A	rs141765090		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113512221G>A	ENST00000487903.1	+	21	2596	c.2508G>A	c.(2506-2508)gcG>gcA	p.A836A	ATP11A_ENST00000375630.2_Silent_p.A836A|ATP11A_ENST00000283558.8_Silent_p.A836A|ATP11A_ENST00000375645.3_Silent_p.A836A			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	836					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TTCTGGAAGCGCACGTGGGCA	0.493000													11	58					0	0	1	0	0
FAM64A	54478	broad.mit.edu	37	17	6350973	6350973	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:6350973G>A	ENST00000572447.1	+	3	594	c.485G>A	c.(484-486)cGc>cAc	p.R162H	FAM64A_ENST00000571373.1_Missense_Mutation_p.R162H|FAM64A_ENST00000570337.2_Missense_Mutation_p.R162H|FAM64A_ENST00000572595.2_Missense_Mutation_p.R193H|FAM64A_ENST00000576056.1_Missense_Mutation_p.R162H|FAM64A_ENST00000250056.8_Missense_Mutation_p.R162H	NM_019013.2	NP_061886.2	Q9BSJ6	FA64A_HUMAN	family with sequence similarity 64, member A	162						nucleolus	protein binding			breast(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				COAD - Colon adenocarcinoma(228;0.141)		GAGCATCACCGCCTCTCTGTC	0.652000													3	10					0	0	1	0	0
RABEP1	9135	broad.mit.edu	37	17	5241315	5241315	+	Splice_Site	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:5241315C>G	ENST00000262477.6	+	5	754	c.528_splice	c.e5-1	p.A177_splice	RABEP1_ENST00000537505.1_Splice_Site_p.A134_splice|RABEP1_ENST00000546142.2_Splice_Site_p.A177_splice|RABEP1_ENST00000341923.6_Splice_Site_p.A177_splice|RABEP1_ENST00000408982.2_Splice_Site_p.A177_splice	NM_004703.4	NP_004694.2	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	177					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	8						TAACCATAGGCCCAAGAGGAT	0.353000													32	45					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32756565	32756565	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:32756565C>T	ENST00000421745.2	+	61	12372	c.12238C>T	c.(12238-12240)Ctg>Ttg	p.L4080L		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4080					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AATGGGTGGACTGGCTCTTAT	0.413000													9	4					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105260949	105260949	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:105260949G>A	ENST00000507740.1	+	19	3175	c.2939G>A	c.(2938-2940)cGc>cAc	p.R980H	RIMS2_ENST00000262231.10_Missense_Mutation_p.R1005H|RIMS2_ENST00000436393.2_Missense_Mutation_p.R1184H|RIMS2_ENST00000406091.3_Missense_Mutation_p.R1166H|RIMS2_ENST00000339750.2_Missense_Mutation_p.R102H	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1228					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCTGGTGTTCGCTTGGCCTCT	0.463000										HNSCC(12;0.0054)			34	39					0	0	1	0	0
RNF6	6049	broad.mit.edu	37	13	26793670	26793670	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:26793670G>T	ENST00000381588.4	-	3	869	c.117C>A	c.(115-117)gcC>gcA	p.A39A	RNF6_ENST00000346166.3_Silent_p.A39A|RNF6_ENST00000399762.2_5'UTR|RNF6_ENST00000381570.3_Silent_p.A39A|RNF6_ENST00000468480.1_5'UTR	NM_005977.3	NP_005968.1	Q9Y252	RNF6_HUMAN	ring finger protein (C3H2C3 type) 6	39					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(3)|ovary(2)|prostate(2)|skin(2)	23	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		ACTGATAATAGGCCTCTTCTC	0.413000													26	43					1.55469e-16	1.7083e-16	1	1	0
IRAK3	0	broad.mit.edu	37	12	66620608	66620608	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:66620608G>A	ENST00000261233.4	+	7	1180	c.759G>A	c.(757-759)ttG>ttA	p.L253L	IRAK3_ENST00000457197.2_Silent_p.L192L	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	253	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		TTGACAGATTGCAGTGTGTAG	0.428000													10	23					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940490	22940490	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:22940490C>A	ENST00000397104.3	-	5	1947	c.1948G>T	c.(1948-1950)Gct>Tct	p.A650S	ZNF99_ENST00000596209.1_Missense_Mutation_p.A741S					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CACTTAAAAGCTTTACCACAT	0.373000													17	34					1.56452e-12	1.69366e-12	1	1	0
ZSWIM3	140831	broad.mit.edu	37	20	44505430	44505430	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:44505430C>T	ENST00000255152.2	+	2	442	c.233C>T	c.(232-234)gCg>gTg	p.A78V	ZSWIM3_ENST00000454862.2_Missense_Mutation_p.A72V	NM_080752.3	NP_542790.2	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM-type containing 3	78							zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	35		Myeloproliferative disorder(115;0.0122)				ATGTGCCCAGCGTACTTGCTC	0.463000													29	35					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134372	128134372	+	Missense_Mutation	SNP	C	C	T	rs144858181		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:128134372C>T	ENST00000368250.1	-	5	1675	c.1177G>A	c.(1177-1179)Gtg>Atg	p.V393M	THEMIS_ENST00000537166.1_Missense_Mutation_p.V437M|THEMIS_ENST00000543064.1_Missense_Mutation_p.V472M|THEMIS_ENST00000368248.2_Missense_Mutation_p.V472M			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	472	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus		p.V472L(1)		breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						GCAGCCAACACGTCCTCTTCA	0.483000													16	29					0	0	1	0	0
FASTKD1	79675	broad.mit.edu	37	2	170428528	170428528	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:170428528T>C	ENST00000453153.2	-	2	358	c.12A>G	c.(10-12)acA>acG	p.T4T	FASTKD1_ENST00000453929.2_Silent_p.T4T	NM_024622.3	NP_078898.3	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	4					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(5)|large_intestine(10)|lung(9)|ovary(4)|prostate(3)	37						GGAAAACAGGTGTTTTTTTCA	0.368000													30	34					0	0	1	0	0
ZNF569	148266	broad.mit.edu	37	19	37905219	37905219	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:37905219T>A	ENST00000316950.6	-	6	898	c.341A>T	c.(340-342)gAa>gTa	p.E114V	ZNF569_ENST00000392150.2_5'UTR|ZNF569_ENST00000392149.2_Missense_Mutation_p.E114V|ZNF569_ENST00000592490.1_3'UTR	NM_152484.2	NP_689697.2	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTTTTGACATTCATTGCCTTT	0.348000													19	34					0	0	1	0	0
SELPLG	0	broad.mit.edu	37	12	109017668	109017668	+	Missense_Mutation	SNP	G	G	A	rs63748999		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:109017668G>A	ENST00000550948.1	-	2	640	c.416C>T	c.(415-417)aCg>aTg	p.T139M	SELPLG_ENST00000228463.6_Missense_Mutation_p.T155M|SELPLG_ENST00000388962.3_Intron			Q14242	SELPL_HUMAN	selectin P ligand	139	12 X 10 AA tandem repeats.		Missing (in short form; not an alternative splicing; dbSNP:rs63748999).		blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(3)|skin(1)	12						CTGTGCCTCCGTGGGCACTGG	0.612000													18	33					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16553918	16553918	+	Translation_Start_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:16553918C>T	ENST00000354981.2	-	1	160	c.3G>A	c.(1-3)atG>atA	p.M1I	KIF16B_ENST00000378003.2_5'UTR|KIF16B_ENST00000408042.1_Start_Codon_SNP_p.M1I|KIF16B_ENST00000355755.3_Start_Codon_SNP_p.M1I	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	1	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						TGACCGATGCCATCGCTCATC	0.731000													3	8					0	0	1	0	0
RHBDF1	64285	broad.mit.edu	37	16	113790	113790	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:113790G>A	ENST00000262316.6	-	4	399	c.257C>T	c.(256-258)gCc>gTc	p.A86V	RHBDF1_ENST00000454039.2_Missense_Mutation_p.A86V	NM_022450.3	NP_071895.3	Q96CC6	RHDF1_HUMAN	rhomboid 5 homolog 1 (Drosophila)	86					cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	18		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				AAACCAGTCGGCGGTCCCCCT	0.662000													9	16					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80699368	80699368	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:80699368G>A	ENST00000458043.2	+	28	3205	c.3199G>A	c.(3199-3201)Gga>Aga	p.G1067R	OTOGL_ENST00000547103.1_Missense_Mutation_p.G1067R	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CAAGCTATCAGGATTGTGTGG	0.328000													6	9					0	0	1	0	0
C7orf50	84310	broad.mit.edu	37	7	1049777	1049777	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:1049777G>A	ENST00000397098.3	-	3	1058	c.132C>T	c.(130-132)ggC>ggT	p.G44G	C7orf50_ENST00000488073.1_5'UTR|C7orf50_ENST00000357429.6_Silent_p.G44G|C7orf50_ENST00000397100.2_Silent_p.G44G			Q9BRJ6	CG050_HUMAN	chromosome 7 open reading frame 50	44							protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		GCACAGCTTCGCCCTGAAAGT	0.607000													4	19					0	0	1	0	0
BECN1	8678	broad.mit.edu	37	17	40962900	40962900	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40962900C>T	ENST00000361523.4	-	12	1363	c.1231G>A	c.(1231-1233)Ggc>Agc	p.G411S	BECN1_ENST00000438274.3_3'UTR|BECN1_ENST00000590099.1_Missense_Mutation_p.G411S|CNTD1_ENST00000315066.5_3'UTR	NM_003766.3	NP_003757.1	Q14457	BECN1_HUMAN	beclin 1, autophagy related	411					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	13		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		GAATAGGAGCCGCCACTGCCT	0.463000													28	37					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35716542	35716542	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35716542G>A	ENST00000314888.9	-	20	2823	c.2470C>T	c.(2470-2472)Cga>Tga	p.R824*	TLN1_ENST00000540444.1_Nonsense_Mutation_p.R824*	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	824				R -> G (in Ref. 1; AAD13152 and 2; AAF23322).	axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CGGGCCTGTCGCACCATCTCC	0.582000													27	43					0	0	1	0	0
HSPA12A	259217	broad.mit.edu	37	10	118440697	118440697	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118440697C>T	ENST00000369209.3	-	9	1097	c.993G>A	c.(991-993)ccG>ccA	p.P331P		NM_025015.2	NP_079291.2	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	331							ATP binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32				all cancers(201;0.0158)		GGTGTCCCTCCGGTAACCGGA	0.488000													29	37					0	0	1	0	0
XPR1	9213	broad.mit.edu	37	1	180780559	180780559	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:180780559C>T	ENST00000367590.4	+	7	896	c.698C>T	c.(697-699)aCt>aTt	p.T233I	XPR1_ENST00000367589.3_Missense_Mutation_p.T233I	NM_004736.3	NP_004727.2	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor 1	233						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	35						CCAGCATGGACTACTTTTAGA	0.323000													6	91					0	0	1	0	0
SYNGR3	9143	broad.mit.edu	37	16	2042693	2042693	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2042693C>T	ENST00000248121.2	+	3	552	c.394C>T	c.(394-396)Cgc>Tgc	p.R132C	SYNGR3_ENST00000562045.1_Silent_p.S43S	NM_004209.5	NP_004200.2	O43761	SNG3_HUMAN	synaptogyrin 3	132	MARVEL.				positive regulation of transporter activity	cell junction|integral to plasma membrane|synaptic vesicle				endometrium(1)|lung(2)	3						TCAGTGGCAGCGCACGGCGCC	0.706000													7	12					0	0	1	0	0
CCDC130	81576	broad.mit.edu	37	19	13873818	13873818	+	Missense_Mutation	SNP	C	C	T	rs149179548	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13873818C>T	ENST00000586600.1	+	11	1630	c.1127C>T	c.(1126-1128)aCg>aTg	p.T376M	CCDC130_ENST00000221554.8_Missense_Mutation_p.T376M			P13994	CC130_HUMAN	coiled-coil domain containing 130	376					response to virus		protein binding			endometrium(2)|kidney(1)|large_intestine(3)|ovary(1)|skin(2)|urinary_tract(1)	10			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			ACCCCCGACACGCGGCACCCC	0.682000													13	11					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56648679	56648679	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56648679G>A	ENST00000267116.7	-	6	641	c.520C>T	c.(520-522)Cgg>Tgg	p.R174W		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	174							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						AGAGGCTGCCGCTCCTTTTTG	0.493000													32	38					0	0	1	0	0
SDR39U1	56948	broad.mit.edu	37	14	24909614	24909614	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24909614C>T	ENST00000554698.1	-	4	740	c.233G>A	c.(232-234)gGc>gAc	p.G78D	KHNYN_ENST00000251343.5_3'UTR|SDR39U1_ENST00000399395.3_Missense_Mutation_p.G186D|SDR39U1_ENST00000555561.1_5'UTR|SDR39U1_ENST00000538105.2_Missense_Mutation_p.G104D|SDR39U1_ENST00000399390.1_Missense_Mutation_p.G91D|SDR39U1_ENST00000553930.1_Missense_Mutation_p.G61D|SDR39U1_ENST00000555365.1_Missense_Mutation_p.G19D			Q9NRG7	D39U1_HUMAN	short chain dehydrogenase/reductase family 39U, member 1	212							binding			NS(1)|central_nervous_system(1)|large_intestine(2)|pancreas(1)	5						GAATTGGTGGCCTGAGCCGAT	0.637000													6	12					0	0	1	0	0
AC010731.4	0	broad.mit.edu	37	2	207508964	207508964	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:207508964G>A	ENST00000543490.1	+	0	179																											TAGGGCCATGGCTGATCCTGG	0.483000													7	12					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35876342	35876342	+	Silent	SNP	C	C	T	rs150593442		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:35876342C>T	ENST00000303115.3	+	8	1263	c.1134C>T	c.(1132-1134)gaC>gaT	p.D378D	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	378					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GTGCATGTGACGCCCCTATTC	0.537000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						23	29					0	0	1	0	0
FIZ1	84922	broad.mit.edu	37	19	56109064	56109064	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56109064G>A	ENST00000221665.3	-	2	257	c.168C>T	c.(166-168)tgC>tgT	p.C56C	FIZ1_ENST00000592585.1_Intron	NM_032836.2	NP_116225.2	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	56					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)	11			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		AACCCTTGCCGCAGCGCGGAC	0.657000													24	30					0	0	1	0	0
TM9SF1	10548	broad.mit.edu	37	14	24658773	24658773	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24658773G>A	ENST00000556387.1	-	10	2329	c.2296C>T	c.(2296-2298)Cgc>Tgc	p.R766C	RP11-468E2.2_ENST00000561419.1_Silent_p.G93G|TM9SF1_ENST00000528669.1_Missense_Mutation_p.R540C|TM9SF1_ENST00000530611.1_Missense_Mutation_p.R766C|TM9SF1_ENST00000261789.4_Missense_Mutation_p.R557C|TM9SF1_ENST00000524835.1_Missense_Mutation_p.R470C			O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1	557					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				NS(1)|breast(4)|endometrium(3)|large_intestine(11)|lung(4)|ovary(1)	24				GBM - Glioblastoma multiforme(265;0.0183)		ATGTTGGAGCGCCGGGCATAA	0.522000													12	26					0	0	1	0	0
IGKV2D-29	0	broad.mit.edu	37	2	89986855	89986855	+	RNA	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:89986855A>T	ENST00000491977.1	+	0	166																											CTGCAAGTCTAGTCAGAGCCT	0.517000													21	13					0	0	1	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19204062	19204062	+	Missense_Mutation	SNP	C	C	T	rs144311914		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:19204062C>T	ENST00000375341.3	-	10	1242	c.985G>A	c.(985-987)Gtg>Atg	p.V329M	RP13-279N23.2_ENST00000494072.3_3'UTR|ALDH4A1_ENST00000538309.1_Missense_Mutation_p.V269M|ALDH4A1_ENST00000538839.1_Missense_Mutation_p.V329M|ALDH4A1_ENST00000290597.5_Missense_Mutation_p.V329M	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	329					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	ACGCTCTCCACGTCGGCCGAG	0.667000													4	10					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39963546	39963546	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39963546G>A	ENST00000599117.1	+	23	2499	c.2132G>A	c.(2131-2133)cGc>cAc	p.R711H	SUPT5H_ENST00000432763.2_Missense_Mutation_p.R711H|SUPT5H_ENST00000598725.1_Missense_Mutation_p.R711H|SUPT5H_ENST00000402194.2_Missense_Mutation_p.R707H|SUPT5H_ENST00000359191.6_Missense_Mutation_p.R707H			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	711	KOW 5.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity	p.R711H(1)		breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGACCGTGCGCATCTCCCAG	0.692000													11	13					0	0	1	0	0
CSNK2B	1460	broad.mit.edu	37	6	31637620	31637620	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31637620G>A	ENST00000375885.4	+	7	834	c.622G>A	c.(622-624)Ggt>Agt	p.G208S	CSNK2B_ENST00000375866.2_Missense_Mutation_p.G189S|CSNK2B_ENST00000375865.2_Missense_Mutation_p.G189S|CSNK2B_ENST00000375882.2_Missense_Mutation_p.G189S|CSNK2B-LY6G5B-1181_ENST00000375880.2_Intron			P67870	CSK2B_HUMAN	casein kinase 2, beta polypeptide	189					adiponectin-mediated signaling pathway|axon guidance|cellular protein complex assembly|negative regulation of cell proliferation|regulation of DNA binding|Wnt receptor signaling pathway	cytosol|nucleus|protein kinase CK2 complex	identical protein binding|protein domain specific binding|protein kinase regulator activity|receptor binding|transcription factor binding			central_nervous_system(5)|endometrium(1)|large_intestine(2)|liver(1)|urinary_tract(1)	10						TAGGCTCTACGGTTTCAAGAT	0.612000													16	25					0	0	1	0	0
GPD2	2820	broad.mit.edu	37	2	157425436	157425436	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:157425436T>G	ENST00000310454.6	+	10	1637	c.1265T>G	c.(1264-1266)gTt>gGt	p.V422G	GPD2_ENST00000540309.1_Intron|GPD2_ENST00000409125.4_Missense_Mutation_p.V195G|GPD2_ENST00000409674.1_Missense_Mutation_p.V422G|GPD2_ENST00000438166.2_Missense_Mutation_p.V422G	NM_001083112.2	NP_001076581.2	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2 (mitochondrial)	422					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|stomach(1)	22						AATCATGTTGTTGATATCAGT	0.408000													57	102					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103053706	103053706	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:103053706G>A	ENST00000264260.2	+	6	1203	c.614G>A	c.(613-615)cGa>cAa	p.R205Q	IL18RAP_ENST00000409369.1_Missense_Mutation_p.R63Q	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	205	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						AGGAGCAACCGAATCGTAGTG	0.383000													18	43					0	0	1	0	0
C14orf166B	145497	broad.mit.edu	37	14	77297581	77297581	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:77297581C>T	ENST00000393774.3	+	3	377	c.253C>T	c.(253-255)Ctg>Ttg	p.L85L	C14orf166B_ENST00000450042.2_Silent_p.L68L|C14orf166B_ENST00000460005.1_3'UTR	NM_194287.2	NP_919263.2	Q0VAA2	CN16B_HUMAN	chromosome 14 open reading frame 166B	85										breast(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(1)	18			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		ACAAAAGGAGCTGTACCTGGA	0.522000													13	23					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100367552	100367552	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100367552G>A	ENST00000542585.1	+	0	5351				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GAACAGCATGGCAGACGCCTG	0.542000													2	1					0	0	1	0	0
GPS2	2874	broad.mit.edu	37	17	7216091	7216091	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7216091C>T	ENST00000380728.2	-	11	1268	c.968G>A	c.(967-969)cGa>cAa	p.R323Q	GPS2_ENST00000389167.5_Missense_Mutation_p.R323Q|RP11-542C16.2_ENST00000575474.1_3'UTR|GPS2_ENST00000391950.3_Intron			Q13227	GPS2_HUMAN	G protein pathway suppressor 2	323					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			breast(1)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(4)	24		Prostate(122;0.157)				GTGGTAGAATCGCGGGTTCTG	0.552000													13	75					0	0	1	0	0
SREK1	140890	broad.mit.edu	37	5	65474638	65474638	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:65474638A>G	ENST00000334121.6	+	12	1976	c.1817A>G	c.(1816-1818)cAc>cGc	p.H606R	SREK1_ENST00000284041.3_3'UTR|SREK1_ENST00000380918.3_Missense_Mutation_p.H490R	NM_001077199.2|NM_001270492.1	NP_001070667.1|NP_001257421.1	Q8WXA9	SREK1_HUMAN	splicing regulatory glutamine/lysine-rich protein 1	490					mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)	9						AAAATACAGCACAATGGGAAT	0.413000													16	16					0	0	1	0	0
AC096574.4	0	broad.mit.edu	37	2	239141089	239141089	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:239141089G>A	ENST00000456601.1	+	0	765																											ATCAGATTGCGCGGTCTCTTT	0.488000													13	41					0	0	1	0	0
TRAV34	0	broad.mit.edu	37	14	22676003	22676003	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22676003C>T	ENST00000390461.2	+	0	327																											GCCATGCAGGCATCTACCTCT	0.522000													18	13					0	0	1	0	0
PPCS	79717	broad.mit.edu	37	1	42922450	42922450	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:42922450G>A	ENST00000372561.3	+	1	221	c.214G>A	c.(214-216)Gcc>Acc	p.A72T	PPCS_ENST00000372556.3_Intron|PPCS_ENST00000455780.1_Intron|PPCS_ENST00000372560.3_Missense_Mutation_p.A72T|PPCS_ENST00000472013.1_3'UTR|PPCS_ENST00000372562.1_Intron	NM_024664.2	NP_078940.2	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase	72					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|skin(3)	12	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CTCGGCCGAGGCCTTCCTAGC	0.672000													49	73					0	0	1	0	0
GPATCH2L	55668	broad.mit.edu	37	14	76647149	76647149	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:76647149G>A	ENST00000261530.7	+	8	1216	c.1150G>A	c.(1150-1152)Gat>Aat	p.D384N	GPATCH2L_ENST00000553588.1_Silent_p.P4P|GPATCH2L_ENST00000312858.5_Missense_Mutation_p.D379N	NM_017926.2	NP_060396.2			G patch domain containing 2-like																		TGTTCTTGCCGATGCTTCTCA	0.433000													59	90					0	0	1	0	0
MFAP1	4236	broad.mit.edu	37	15	44101970	44101970	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:44101970G>A	ENST00000267812.3	-	7	1262	c.1030C>T	c.(1030-1032)Cgg>Tgg	p.R344W		NM_005926.2	NP_005917.2	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	344						microfibril				breast(2)|endometrium(1)|kidney(1)|lung(6)|skin(2)|upper_aerodigestive_tract(3)	15		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		AAGGCACCCCGGTGATAATAC	0.398000													54	89					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17837806	17837806	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:17837806G>A	ENST00000378814.5	-	10	838	c.839C>T	c.(838-840)aCa>aTa	p.T280I	KIF13A_ENST00000378843.2_Missense_Mutation_p.T280I|KIF13A_ENST00000378826.2_Missense_Mutation_p.T280I|KIF13A_ENST00000378816.5_Missense_Mutation_p.T280I|KIF13A_ENST00000259711.6_Missense_Mutation_p.T280I	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	280					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CCCCAAGGTTGTAAGCGATCT	0.373000													6	8					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58232531	58232531	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58232531G>A	ENST00000317398.6	-	4	1018	c.923C>T	c.(922-924)aCt>aTt	p.T308I	AC003006.7_ENST00000599221.1_Intron|ZNF671_ENST00000335820.3_Missense_Mutation_p.T210I	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	308					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CCTTTCTCCAGTGTGGATTCT	0.483000													38	54					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93026864	93026864	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:93026864G>A	ENST00000523629.1	-	4	865	c.411C>T	c.(409-411)ggC>ggT	p.G137G	RUNX1T1_ENST00000436581.2_Silent_p.G148G|RUNX1T1_ENST00000265814.3_Silent_p.G137G|RUNX1T1_ENST00000520724.1_Silent_p.G100G|RUNX1T1_ENST00000396218.1_Silent_p.G110G|RUNX1T1_ENST00000422361.2_Silent_p.G100G|RUNX1T1_ENST00000360348.2_Silent_p.G100G|RUNX1T1_ENST00000521553.1_Silent_p.G100G|RUNX1T1_ENST00000518844.1_Silent_p.G110G	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	137	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			AAATGTCATTGCCAAACTGCT	0.512000													8	58					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276233	186276233	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:186276233C>T	ENST00000445192.2	+	7	1427	c.1382C>T	c.(1381-1383)cCc>cTc	p.P461L	PRG4_ENST00000367483.4_Missense_Mutation_p.P420L|PRG4_ENST00000367486.3_Missense_Mutation_p.P418L|PRG4_ENST00000367485.4_Missense_Mutation_p.P368L|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	461	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						GAGCCTACACCCACCACTCCC	0.657000													22	32					0	0	1	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129537	248129537	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:248129537C>T	ENST00000366480.3	+	1	1003	c.904C>T	c.(904-906)Cca>Tca	p.P302S	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TCTACTGAACCCATTTATCTA	0.463000													6	59					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62205518	62205518	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:62205518C>T	ENST00000261517.5	-	62	8615	c.8542G>A	c.(8542-8544)Gag>Aag	p.E2848K	VPS13C_ENST00000395898.3_Missense_Mutation_p.E2805K|VPS13C_ENST00000249837.3_Missense_Mutation_p.E2805K|VPS13C_ENST00000395896.4_Missense_Mutation_p.E2848K	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	2848					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						ACCAGGTACTCCATATTGTTG	0.398000													6	103					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126371551	126371551	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126371551G>A	ENST00000394329.3	+	9	9393	c.9380G>A	c.(9379-9381)aGc>aAc	p.S3127N	FAT4_ENST00000335110.5_Missense_Mutation_p.S1425N	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3127	Cadherin 30.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATTAAGTACAGCATTTCTTCA	0.408000													18	27					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3611718	3611718	+	RNA	SNP	C	C	T	rs148712383	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3611718C>T	ENST00000301749.7	-	0	2405				NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000603507.1_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTTCTGAATGCGACAGTCCTT	0.597000													13	41					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74289739	74289739	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74289739C>T	ENST00000262765.5	-	4	750	c.571G>A	c.(571-573)Gca>Aca	p.A191T		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	191							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CCAGGACGTGCATTTCTTCTT	0.522000													17	29					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32011641	32011641	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32011641G>A	ENST00000375244.3	-	35	11616	c.11415C>T	c.(11413-11415)ggC>ggT	p.G3805G	TNXB_ENST00000451343.1_Silent_p.G234G|TNXB_ENST00000375247.2_Silent_p.G3803G			P22105	TENX_HUMAN	tenascin XB	3850	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TCCGGGCCTGGCCATCCACCT	0.642000													18	31					0	0	1	0	0
FNIP2	57600	broad.mit.edu	37	4	159782886	159782886	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:159782886C>T	ENST00000264433.6	+	12	1498	c.1423C>T	c.(1423-1425)Ctg>Ttg	p.L475L	FNIP2_ENST00000379346.3_Silent_p.L498L	NM_020840.1	NP_065891.1	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	475					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		AGTGAACATGCTGGCCAAAAC	0.468000													42	80					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51795013	51795013	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:51795013C>T	ENST00000251076.5	-	17	3269	c.2982G>A	c.(2980-2982)acG>acA	p.T994T	DMXL2_ENST00000449909.3_Intron|DMXL2_ENST00000543779.2_Silent_p.T994T	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	994						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		CTGCTGAAGGCGTTGCTCTTA	0.398000													21	54					0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136418857	136418857	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:136418857C>T	ENST00000264160.4	+	18	2311	c.1941C>T	c.(1939-1941)tgC>tgT	p.C647C	R3HDM1_ENST00000410054.1_Silent_p.C592C|R3HDM1_ENST00000409606.1_Silent_p.C648C|R3HDM1_ENST00000409478.1_Silent_p.C519C|R3HDM1_ENST00000329971.3_Silent_p.C518C	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	647							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		CCTGTTATTGCGCTCCAGGCC	0.433000													25	65					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234536927	234536927	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:234536927C>A	ENST00000040877.1	-	25	4070	c.4071_splice	c.e25+1	p.E1357_splice	TARBP1_ENST00000483404.1_5'UTR	NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1357					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			CTCTACTCACCTCTAGACAAT	0.348000													12	19					4.3838e-07	4.58243e-07	1	1	0
SCFD1	23256	broad.mit.edu	37	14	31188567	31188567	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:31188567C>T	ENST00000458591.2	+	21	1947	c.1720C>T	c.(1720-1722)Ctg>Ttg	p.L574L	SCFD1_ENST00000544052.2_Silent_p.L507L|SCFD1_ENST00000421551.3_Silent_p.L515L|SCFD1_ENST00000396629.2_Silent_p.L482L|SCFD1_ENST00000541123.1_Silent_p.L389L	NM_016106.3	NP_057190.2	Q8WVM8	SCFD1_HUMAN	sec1 family domain containing 1	574					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		TCCCAAAATGCTGCGGGGCAA	0.338000													26	41					0	0	1	0	0
CARD9	64170	broad.mit.edu	37	9	139264857	139264857	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139264857G>A	ENST00000371732.5	-	6	1005	c.840C>T	c.(838-840)atC>atT	p.I280I	CARD9_ENST00000371734.3_Silent_p.I280I|CARD9_ENST00000315908.7_Silent_p.I280I	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	280					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		CCAGTACCTGGATGTAGGGGC	0.687000													7	8					0	0	1	0	0
GPR12	0	broad.mit.edu	37	13	27333935	27333935	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:27333935G>A	ENST00000405846.3	-	2	251	c.30C>T	c.(28-30)agC>agT	p.S10S	GPR12_ENST00000381436.2_Silent_p.S10S	NM_005288.3	NP_005279.1	P47775	GPR12_HUMAN	G protein-coupled receptor 12	10						integral to plasma membrane				endometrium(7)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		GAGGCAGCCCGCTTAAATTGA	0.502000													21	26					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135176063	135176063	+	Silent	SNP	G	G	A	rs117410554	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:135176063G>A	ENST00000372169.2	-	12	5684	c.5502C>T	c.(5500-5502)caC>caT	p.H1834H	SETX_ENST00000224140.5_Silent_p.H1834H|SETX_ENST00000393220.1_Silent_p.H1834H			Q7Z333	SETX_HUMAN	senataxin	1834					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		AATGATATTCGTGGAGATCTT	0.358000													46	59					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48239325	48239325	+	Splice_Site	SNP	G	G	A	rs142338810	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:48239325G>A	ENST00000394747.1	-	12	2153	c.1805_splice	c.e12+1	p.R602_splice	ABCC11_ENST00000353782.5_Splice_Site_p.R602_splice|ABCC11_ENST00000394748.1_Splice_Site_p.R602_splice|ABCC11_ENST00000356608.2_Splice_Site_p.R602_splice|ABCC11_ENST00000537808.1_Splice_Site_p.R602_splice	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	602	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GGAGCTTACCGGGCCTTGTCA	0.602000													14	96					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122392096	122392096	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:122392096C>T	ENST00000288912.4	+	10	2245	c.1391C>T	c.(1390-1392)gCc>gTc	p.A464V	WDR66_ENST00000397454.2_Missense_Mutation_p.A464V	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	464							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		ATACTCTCAGCCACAATGGAA	0.433000													4	123					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2419141	2419141	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:2419141G>A	ENST00000449969.1	+	8	1299	c.1138G>A	c.(1138-1140)Gcc>Acc	p.A380T	PLCH2_ENST00000378488.3_Missense_Mutation_p.A407T|PLCH2_ENST00000419816.2_Missense_Mutation_p.A407T|PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000378486.3_Missense_Mutation_p.A407T|PLCH2_ENST00000288766.5_Intron			O75038	PLCH2_HUMAN	phospholipase C, eta 2	407	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CAACAAATATGCCTTCATCAA	0.572000													13	14					0	0	1	0	0
AMIGO3	386724	broad.mit.edu	37	3	49758036	49758036	+	Translation_Start_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49758036C>A	ENST00000535833.1	-	0	2313				GMPPB_ENST00000480687.1_3'UTR|RNF123_ENST00000497099.1_3'UTR|RNF123_ENST00000327697.6_Missense_Mutation_p.P1198H|GMPPB_ENST00000308375.6_3'UTR|RNF123_ENST00000433785.1_Missense_Mutation_p.P310H			Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3						heterophilic cell-cell adhesion	integral to membrane				endometrium(1)|pancreas(1)|prostate(2)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCCCCAGCACCTGGCACTGCT	0.627000													7	33					3.09899e-07	3.24337e-07	1	1	0
VIM	7431	broad.mit.edu	37	10	17271519	17271519	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:17271519C>T	ENST00000544301.1	+	2	511	c.98C>T	c.(97-99)aCg>aTg	p.T33M	VIM_ENST00000224237.5_Missense_Mutation_p.T33M|VIM-AS1_ENST00000605833.1_RNA|VIM_ENST00000485947.1_3'UTR	NM_003380.3	NP_003371.2	P08670	VIME_HUMAN	vimentin	33	Head.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TACGTGACTACGTCCACCCGC	0.721000													5	8					0	0	1	0	0
SLC22A20	0	broad.mit.edu	37	11	65004274	65004274	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65004274G>A	ENST00000525437.1	+	0	1524							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						TGGGGCCACCGCAATCCTGGC	0.677000													22	62					0	0	1	0	0
JUP	3728	broad.mit.edu	37	17	39927978	39927978	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39927978C>A	ENST00000393931.3	-	2	247	c.129G>T	c.(127-129)atG>atT	p.M43I	JUP_ENST00000393930.1_Missense_Mutation_p.M43I|JUP_ENST00000310706.5_Missense_Mutation_p.M43I|JUP_ENST00000540235.1_Missense_Mutation_p.M43I	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	43					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity	p.K40_Y53del(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		CATCCTCCTCCATGATGCCCT	0.617000													7	20					2.17888e-05	2.24846e-05	1	1	0
STX10	8677	broad.mit.edu	37	19	13256153	13256153	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13256153G>A	ENST00000589083.1	-	5	472	c.420C>T	c.(418-420)agC>agT	p.S140S	STX10_ENST00000242770.5_Silent_p.S140S|STX10_ENST00000587230.1_Silent_p.S140S|STX10_ENST00000343587.5_Silent_p.S91S	NM_001271610.1	NP_001258539.1	O60499	STX10_HUMAN	syntaxin 10	140					Golgi vesicle transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane	SNAP receptor activity			breast(1)|endometrium(1)|kidney(1)|lung(2)|prostate(1)	6			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			CCGAGACTGCGCTGGCATCCA	0.622000													11	15					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81050916	81050916	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:81050916C>T	ENST00000334512.5	+	10	1313	c.741C>T	c.(739-741)agC>agT	p.S247S	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	247					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			ACCCCGGCAGCGGGGGCTTTG	0.647000													9	19					0	0	1	0	0
ZNF3	7551	broad.mit.edu	37	7	99669204	99669204	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99669204G>A	ENST00000303915.6	-	5	1870	c.903C>T	c.(901-903)caC>caT	p.H301H	ZNF3_ENST00000424697.1_Silent_p.H301H|ZNF3_ENST00000299667.4_Silent_p.H301H|ZNF3_ENST00000413658.2_Intron			P17036	ZNF3_HUMAN	zinc finger protein 3	301					cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	25	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			TTCTCTGATGGTGGGTGAGGG	0.532000													14	34					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	447679	447679	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:447679G>A	ENST00000512944.1	+	3	365	c.176G>A	c.(175-177)cGc>cAc	p.R59H	EXOC3_ENST00000315013.5_Missense_Mutation_p.R59H	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	70					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GACGGGGTGCGCACAGGCCTC	0.587000													4	4					0	0	1	0	0
KCNG2	26251	broad.mit.edu	37	18	77659290	77659290	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:77659290C>T	ENST00000316249.3	+	2	875	c.875C>T	c.(874-876)gCg>gTg	p.A292V	KCNG2_ENST00000590307.1_3'UTR	NM_012283.1	NP_036415.1	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G, member 2	292					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity			breast(2)|endometrium(4)|lung(7)|skin(1)|upper_aerodigestive_tract(4)	18		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CTGCTGCGTGCGCTGCGCGTG	0.746000													3	10					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111386472	111386472	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:111386472G>A	ENST00000428084.1	-	44	4867	c.4593_splice	c.e44-1	p.A1532_splice	DOCK4_ENST00000437633.1_Splice_Site_p.A1523_splice|DOCK4_ENST00000494651.2_Splice_Site_p.A406_splice			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1523	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				GACAAAGAATGCCTAGTAAGG	0.413000													4	9					0	0	1	0	0
LUZP1	7798	broad.mit.edu	37	1	23417825	23417825	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:23417825C>A	ENST00000302291.4	-	4	3731	c.2930G>T	c.(2929-2931)aGg>aTg	p.R977M	LUZP1_ENST00000374623.3_Missense_Mutation_p.R977M|LUZP1_ENST00000418342.1_Missense_Mutation_p.R977M|LUZP1_ENST00000314174.5_Missense_Mutation_p.R977M			Q86V48	LUZP1_HUMAN	leucine zipper protein 1	977						nucleus				NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(2)	31		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TGGTCCTACCCTTCGAGTGCC	0.557000													12	16					2.27111e-07	2.37911e-07	1	1	0
MRVI1	10335	broad.mit.edu	37	11	10631334	10631334	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:10631334C>T	ENST00000547195.1	-	10	1739	c.1239G>A	c.(1237-1239)atG>atA	p.M413I	MRVI1_ENST00000552103.1_Missense_Mutation_p.M413I|MRVI1_ENST00000423302.2_Missense_Mutation_p.M504I|MRVI1_ENST00000436272.1_Missense_Mutation_p.M477I|MRVI1_ENST00000558540.1_Missense_Mutation_p.M189I|MRVI1_ENST00000545852.1_Missense_Mutation_p.M189I|MRVI1_ENST00000424001.1_Missense_Mutation_p.M189I|LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000527509.2_Missense_Mutation_p.M413I|MRVI1_ENST00000534266.2_Missense_Mutation_p.M189I|MRVI1_ENST00000421747.1_Missense_Mutation_p.M495I|MRVI1_ENST00000531107.1_Missense_Mutation_p.M496I|MRVI1_ENST00000541483.1_Missense_Mutation_p.M298I	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	477					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		AAATATTAGGCATGACATCTA	0.458000													19	26					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50230313	50230313	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:50230313C>T	ENST00000338821.5	-	23	2738	c.2474G>A	c.(2473-2475)gGc>gAc	p.G825D	ATP9A_ENST00000402822.1_Missense_Mutation_p.G704D|ATP9A_ENST00000311637.5_Missense_Mutation_p.G689D	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	825					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						AAGCAACCGGCCAAGATGCTT	0.507000													49	79					0	0	1	0	0
GART	2618	broad.mit.edu	37	21	34894556	34894556	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:34894556G>A	ENST00000381831.3	-	12	1595	c.1332C>T	c.(1330-1332)atC>atT	p.I444I	GART_ENST00000381839.3_Silent_p.I444I|GART_ENST00000543717.1_5'UTR|GART_ENST00000381815.4_Silent_p.I444I	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	444	AIRS.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	TTCCAGCTGCGATATCTACTC	0.333000													25	13					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121774625	121774625	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:121774625C>T	ENST00000264808.3	-	3	488	c.248G>A	c.(247-249)cGc>cAc	p.R83H	PRDM5_ENST00000394435.2_Missense_Mutation_p.R83H|PRDM5_ENST00000515109.1_Missense_Mutation_p.R83H|PRDM5_ENST00000428209.2_Missense_Mutation_p.R83H	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	83	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						ATGAACGAAGCGAAGCCAGTT	0.473000													112	165					0	0	1	0	0
LPCAT2	54947	broad.mit.edu	37	16	55559532	55559532	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:55559532T>C	ENST00000262134.5	+	2	468	c.284T>C	c.(283-285)cTg>cCg	p.L95P		NM_017839.4	NP_060309.2	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	95					cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	12						CCTGAAAAGCTGACCCACCCA	0.338000													11	53					0	0	1	0	0
SOST	50964	broad.mit.edu	37	17	41835926	41835926	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41835926C>T	ENST00000301691.2	-	1	230	c.184G>A	c.(184-186)Gga>Aga	p.G62R		NM_025237.2	NP_079513.1	Q9BQB4	SOST_HUMAN	sclerostin	62					negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of ossification|negative regulation of protein complex assembly|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway		heparin binding|protein binding			large_intestine(2)|lung(3)|prostate(1)	6		Breast(137;0.00725)		UCEC - Uterine corpus endometrioid carcinoma (308;0.177)|BRCA - Breast invasive adenocarcinoma(366;0.0741)		GGCCGCCCTCCGTTCTCCGCC	0.547000													15	23					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20444660	20444660	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:20444660G>A	ENST00000305051.5	+	1	1058	c.983G>A	c.(982-984)cGg>cAg	p.R328Q		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	328					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGAAGAGTCGGTATCTGAAG	0.388000													21	32					0	0	1	0	0
RANBP17	64901	broad.mit.edu	37	5	170640638	170640638	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:170640638C>T	ENST00000523189.1	+	21	2399	c.2235C>T	c.(2233-2235)taC>taT	p.Y745Y	RANBP17_ENST00000521759.1_3'UTR	NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	745					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATAAAAGGTACCCAACGTACC	0.398000			T	TRD@	ALL								42	78					0	0	1	0	0
ASTE1	28990	broad.mit.edu	37	3	130737469	130737469	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:130737469G>T	ENST00000264992.3	-	4	1835	c.1394C>A	c.(1393-1395)cCc>cAc	p.P465H	ASTE1_ENST00000514044.1_Missense_Mutation_p.P465H	NM_014065.2	NP_054784.2	Q2TB18	ASTE1_HUMAN	asteroid homolog 1 (Drosophila)	465					DNA repair		nuclease activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	22						GACAGCAATGGGCAACTTCAG	0.483000													15	50					1.5739e-10	1.6844e-10	1	1	0
C14orf80	283643	broad.mit.edu	37	14	105960184	105960184	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105960184A>G	ENST00000392523.4	+	5	719	c.598A>G	c.(598-600)Aca>Gca	p.T200A	C14orf80_ENST00000392522.3_Missense_Mutation_p.T200A|C14orf80_ENST00000392527.1_Intron|C14orf80_ENST00000334656.7_Intron|C14orf80_ENST00000329886.7_Intron|C14orf80_ENST00000354560.6_Intron|C14orf80_ENST00000450383.1_Missense_Mutation_p.T22A|C14orf80_ENST00000551054.1_Intron			Q86SX3	CN080_HUMAN	chromosome 14 open reading frame 80	200										central_nervous_system(1)	1		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.239)		CCACCTGTACACACGCGGCTG	0.612000													5	19					0	0	1	0	0
NTSR1	4923	broad.mit.edu	37	20	61340973	61340973	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:61340973C>T	ENST00000370501.3	+	1	785	c.414C>T	c.(412-414)gaC>gaT	p.D138D		NM_002531.2	NP_002522.2	P30989	NTR1_HUMAN	neurotensin receptor 1 (high affinity)	138						endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(16)|prostate(1)|skin(3)	27	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CCTTCGGCGACGCCGGCTGCC	0.687000													18	25					0	0	1	0	0
ATAD3A	55210	broad.mit.edu	37	1	1459697	1459697	+	Silent	SNP	C	C	T	rs150316055		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1459697C>T	ENST00000378755.5	+	11	1372	c.1278C>T	c.(1276-1278)ggC>ggT	p.G426G	ATAD3A_ENST00000536055.1_Silent_p.G299G|ATAD3A_ENST00000378756.3_Silent_p.G378G	NM_018188.3	NP_060658.3	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	426							ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(4)|kidney(6)|large_intestine(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		TCATGACAGGCGGGGACGTGG	0.632000													5	45					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50901733	50901733	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50901733A>G	ENST00000380817.2	-	16	2061	c.1878T>C	c.(1876-1878)cgT>cgC	p.R626R	SBF1_ENST00000348911.6_Silent_p.R627R|SBF1_ENST00000390679.3_Silent_p.R626R	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	626					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		AGTTCATCATACGGACGACAA	0.627000													16	25					0	0	1	0	0
N4BP3	23138	broad.mit.edu	37	5	177546594	177546594	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:177546594G>T	ENST00000274605.5	+	2	369	c.10G>T	c.(10-12)Gcc>Tcc	p.A4S		NM_015111.1	NP_055926.1	O15049	N4BP3_HUMAN	NEDD4 binding protein 3	4						cytoplasmic vesicle membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	9	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATGGCCACAGCCCCAGGCCC	0.642000													18	22					1.67942e-08	1.77343e-08	1	1	0
PSMB3	5691	broad.mit.edu	37	17	36918698	36918698	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36918698C>T	ENST00000225426.4	+	5	600	c.509C>T	c.(508-510)gCc>gTc	p.A170V		NM_002795.2	NP_002786.2	P49720	PSB3_HUMAN	proteasome (prosome, macropain) subunit, beta type, 3	170					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(1)	4						ATCTCCCAAGCCATGCTGAAT	0.527000													23	32					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182027061	182027061	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:182027061G>A	ENST00000339948.3	-	2	292	c.85C>T	c.(85-87)Ctg>Ttg	p.L29L		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						TTCATGCTCAGCATCTGGGTG	0.587000													24	40					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37860417	37860417	+	Silent	SNP	C	C	T	rs142961075	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:37860417C>T	ENST00000264741.5	+	28	3301	c.3045C>T	c.(3043-3045)atC>atT	p.I1015I	AC093415.2_ENST00000430620.1_RNA|AC093415.2_ENST00000429532.1_RNA|AC093415.2_ENST00000450990.1_RNA|AC093415.2_ENST00000457661.1_RNA|AC093415.2_ENST00000420870.1_RNA|AC093415.2_ENST00000445429.1_RNA|AC093415.2_ENST00000366441.2_RNA|AC093415.2_ENST00000438136.1_RNA	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	1015					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		AAGAAATTATCGAAGCTGAGA	0.473000													14	24					0	0	1	0	0
PCDHA5	0	broad.mit.edu	37	5	140201505	140201505	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140201505C>G	ENST00000529859.1	+	1	145	c.145C>G	c.(145-147)Cag>Gag	p.Q49E	PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.Q49E|PCDHA5_ENST00000529619.1_Missense_Mutation_p.Q49E|PCDHA2_ENST00000526136.1_Intron	NM_018908.2	NP_061731.1												p.Q49fs*50(1)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCATCGCGCAGGACCTAGG	0.647000													27	62					0	0	1	0	0
PLEKHA4	0	broad.mit.edu	37	19	49363689	49363689	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49363689C>T	ENST00000263265.6	-	6	949	c.394G>A	c.(394-396)Gtt>Att	p.V132I	PLEKHA4_ENST00000355496.5_Missense_Mutation_p.V132I	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	132	PH.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GCGGCCAAAACGTAGGTCCTC	0.652000													26	30					0	0	1	0	0
INPP4B	8821	broad.mit.edu	37	4	143003203	143003203	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:143003203C>T	ENST00000513000.1	-	26	3056	c.2623G>A	c.(2623-2625)Gcg>Acg	p.A875T	INPP4B_ENST00000262992.4_Missense_Mutation_p.A875T|INPP4B_ENST00000509777.1_Missense_Mutation_p.A875T|INPP4B_ENST00000308502.4_Missense_Mutation_p.A875T|INPP4B_ENST00000508116.1_Missense_Mutation_p.A875T	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	875					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					CAATCCAGCGCTCGGATAAAG	0.343000													20	54					0	0	1	0	0
CCR5	1234	broad.mit.edu	37	3	46414416	46414416	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:46414416C>T	ENST00000343801.4	+	3	380	c.23C>T	c.(22-24)cCa>cTa	p.P8L	CCR5_ENST00000292303.4_Missense_Mutation_p.P8L|CCR5_ENST00000445772.1_Missense_Mutation_p.P8L|RP11-24F11.2_ENST00000451485.1_RNA	NM_000579.3	NP_000570.1	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5 (gene/pseudogene)	8					cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			central_nervous_system(1)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	GTGTCAAGTCCAATCTATGAC	0.418000													38	84					0	0	1	0	0
LILRA2	0	broad.mit.edu	37	19	55085828	55085828	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55085828C>T	ENST00000251377.3	+	4	264	c.131C>T	c.(130-132)cCt>cTt	p.P44L	LILRA2_ENST00000391738.3_Missense_Mutation_p.P44L|LILRA2_ENST00000391737.1_Missense_Mutation_p.P32L|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.P44L|LILRA2_ENST00000495786.1_3'UTR|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000448689.1_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		CAGGGAAGTCCTGTGACCCTC	0.547000													28	34					0	0	1	0	0
RP11-1277A3.2	0	broad.mit.edu	37	5	177059340	177059340	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:177059340C>A	ENST00000515045.1	-	0	588					NR_026921.1																						CTGAAGACAGCTGTAGACTTG	0.488000													8	8					5.18039e-06	5.37127e-06	1	1	0
PRKCQ	5588	broad.mit.edu	37	10	6527171	6527171	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:6527171G>A	ENST00000263125.5	-	10	1060	c.961C>T	c.(961-963)Cca>Tca	p.P321S	PRKCQ_ENST00000397176.2_Missense_Mutation_p.P321S|PRKCQ_ENST00000539722.1_Missense_Mutation_p.P196S	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	321					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						ATGGAGCATGGGAGACCAATT	0.488000													49	73					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	57003379	57003379	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57003379C>T	ENST00000200676.3	+	3	445	c.315C>T	c.(313-315)aaC>aaT	p.N105N	CETP_ENST00000569082.1_3'UTR|CETP_ENST00000379780.2_Silent_p.N105N|CETP_ENST00000566128.1_Silent_p.N40N	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	105					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						CCATTCAGAACGTGTCTGTGG	0.567000													29	46					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101085438	101085438	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:101085438G>T	ENST00000394095.2	-	9	1207	c.1154C>A	c.(1153-1155)gCc>gAc	p.A385D	SENP7_ENST00000314261.7_Missense_Mutation_p.A319D|SENP7_ENST00000394091.1_Missense_Mutation_p.A221D|SENP7_ENST00000348610.3_Missense_Mutation_p.A352D|SENP7_ENST00000394094.2_Missense_Mutation_p.A320D|SENP7_ENST00000358203.3_Missense_Mutation_p.A221D	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	385					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						ACCGGCAGAGGCACTTTTGGT	0.403000													28	44					9.39395e-14	1.02212e-13	1	1	0
HK3	3101	broad.mit.edu	37	5	176317707	176317707	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176317707C>A	ENST00000292432.5	-	6	650	c.559G>T	c.(559-561)Ggt>Tgt	p.G187C		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	187	Glucose-binding (Potential).|Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACCTAAAACCTTTGGTCCAG	0.607000													36	100					3.3946e-10	3.62385e-10	1	1	0
TRIM42	287015	broad.mit.edu	37	3	140409974	140409974	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:140409974C>T	ENST00000286349.3	+	4	2216	c.2025C>T	c.(2023-2025)taC>taT	p.Y675Y		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	675	Fibronectin type-III.					intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						ACACAGAATACGTGTTTAAAG	0.423000													50	80					0	0	1	0	0
SHISA2	387914	broad.mit.edu	37	13	26621051	26621051	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:26621051G>A	ENST00000319420.3	-	2	543	c.488C>T	c.(487-489)aCc>aTc	p.T163I		NM_001007538.1	NP_001007539.1	Q6UWI4	SHSA2_HUMAN	shisa family member 2	163					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)|skin(1)	17						CATGGGGATGGTCTCCATCAA	0.662000													15	26					0	0	1	0	0
UACA	55075	broad.mit.edu	37	15	70979979	70979979	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:70979979G>A	ENST00000322954.6	-	7	687	c.502C>T	c.(502-504)Cgg>Tgg	p.R168W	UACA_ENST00000560441.1_Missense_Mutation_p.R155W|UACA_ENST00000539319.1_Intron|UACA_ENST00000379983.2_Missense_Mutation_p.R155W	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	168						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						AGTGGTGTCCGCCCGTCCTAA	0.393000													29	52					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15372584	15372584	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:15372584T>A	ENST00000281513.5	-	47	6223	c.6198A>T	c.(6196-6198)gaA>gaT	p.E2066D	NBAS_ENST00000441750.1_Missense_Mutation_p.E1946D	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	2066										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						CAACAACACCTTCCAGGACCT	0.478000													19	24					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153760106	153760106	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:153760106C>T	ENST00000297107.6	+	6	990	c.853C>T	c.(853-855)Cgg>Tgg	p.R285W	GALNT10_ENST00000425427.2_Missense_Mutation_p.R285W|GALNT10_ENST00000377661.2_Missense_Mutation_p.R223W|GALNT10_ENST00000519544.1_3'UTR|SAP30L-AS1_ENST00000519727.1_RNA	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	285						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GGATGCCATGCGGGGAGCCTT	0.532000													27	55					0	0	1	0	0
THUMPD3	25917	broad.mit.edu	37	3	9406772	9406772	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9406772C>T	ENST00000345094.3	+	2	354	c.20C>T	c.(19-21)gCc>gTc	p.A7V	THUMPD3_ENST00000515662.2_Missense_Mutation_p.A7V|THUMPD3_ENST00000452837.2_Missense_Mutation_p.A7V|SETD5-AS1_ENST00000468186.1_RNA	NM_001114092.1|NM_015453.2	NP_001107564.1|NP_056268.2	Q9BV44	THUM3_HUMAN	THUMP domain containing 3	7							methyltransferase activity|protein binding|RNA binding			NS(1)|central_nervous_system(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	19	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.101)		ATTGAAGAAGCCACTAACCAA	0.408000													19	51					0	0	1	0	0
PRSS23	11098	broad.mit.edu	37	11	86519563	86519563	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:86519563G>A	ENST00000280258.5	+	2	1303	c.878G>A	c.(877-879)cGc>cAc	p.R293H	PRSS23_ENST00000441050.1_Missense_Mutation_p.R261H|PRSS23_ENST00000533902.2_Intron	NM_007173.4	NP_009104.1	O95084	PRS23_HUMAN	protease, serine, 23	293					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity	p.R293H(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	18		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TTGGTGTATCGCTTCTGTGAC	0.537000													12	63					0	0	1	0	0
COPS8	10920	broad.mit.edu	37	2	238002835	238002835	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:238002835T>C	ENST00000354371.2	+	5	1087	c.434T>C	c.(433-435)gTg>gCg	p.V145A	COPS8_ENST00000409629.1_Missense_Mutation_p.V145A|COPS8_ENST00000409334.1_Intron|COPS8_ENST00000392008.2_Missense_Mutation_p.V96A	NM_006710.4	NP_006701.1	Q99627	CSN8_HUMAN	COP9 signalosome subunit 8	145	PCI.				cullin deneddylation	cytoplasm|signalosome				large_intestine(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	4		Breast(86;0.000162)|Renal(207;0.00339)|all_hematologic(139;0.0123)|Ovarian(221;0.0694)|Acute lymphoblastic leukemia(138;0.0775)|all_lung(227;0.169)|all_neural(83;0.211)		Epithelial(121;7.41e-23)|OV - Ovarian serous cystadenocarcinoma(60;5.42e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000175)|Lung(119;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0258)		GAAGAGGCTGTGAAAGGTAAT	0.418000													27	50					0	0	1	0	0
SP110	3431	broad.mit.edu	37	2	231076266	231076266	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:231076266C>T	ENST00000258381.6	-	6	747	c.670G>A	c.(670-672)Gcc>Acc	p.A224T	SP110_ENST00000392048.3_Missense_Mutation_p.A224T|SP110_ENST00000338556.3_5'UTR|SP110_ENST00000486146.2_5'UTR|SP110_ENST00000540870.1_Missense_Mutation_p.A230T|SP110_ENST00000358662.4_Missense_Mutation_p.A224T|SP110_ENST00000258382.5_Missense_Mutation_p.A224T	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	224					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		TTGTCACTGGCCACTGAATGG	0.448000													17	28					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20652239	20652239	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:20652239A>G	ENST00000525748.1	+	10	1775	c.1502A>G	c.(1501-1503)gAc>gGc	p.D501G	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	501					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	CCTTCCAGGGACACTCTAATT	0.502000													13	56					0	0	1	0	0
IGKV1-9	0	broad.mit.edu	37	2	89309530	89309530	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:89309530C>T	ENST00000493819.1	-	0	357																											CTTCAGGCTGCAGGCTGCTGA	0.478000													53	87					0	0	1	0	0
ITGAL	0	broad.mit.edu	37	16	30506132	30506132	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30506132G>A	ENST00000356798.6	+	13	1644	c.1464G>A	c.(1462-1464)gaG>gaA	p.E488E	ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000358164.5_Silent_p.E405E|ITGAL_ENST00000568012.1_3'UTR	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	488					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TCTATGGGGAGCAGAGAGGAG	0.587000													17	30					0	0	1	0	0
IL10	3586	broad.mit.edu	37	1	206944258	206944258	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:206944258C>T	ENST00000423557.1	-	3	430	c.372G>A	c.(370-372)cgG>cgA	p.R124R	IL10_ENST00000471071.1_5'UTR	NM_000572.2	NP_000563.1	P22301	IL10_HUMAN	interleukin 10	124					anti-apoptosis|B cell differentiation|B cell proliferation|cytoplasmic sequestering of NF-kappaB|inflammatory response|leukocyte chemotaxis|negative regulation of B cell proliferation|negative regulation of cytokine secretion involved in immune response|negative regulation of interferon-alpha biosynthetic process|negative regulation of interleukin-6 production|negative regulation of membrane protein ectodomain proteolysis|negative regulation of MHC class II biosynthetic process|negative regulation of T cell proliferation|positive regulation of B cell apoptosis|positive regulation of cytokine secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|receptor biosynthetic process|regulation of isotype switching|response to glucocorticoid stimulus|type 2 immune response	extracellular space	cytokine activity|growth factor activity|interleukin-10 receptor binding			endometrium(1)|large_intestine(6)|lung(4)|prostate(1)	12	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			TTACACAGCGCCGTAGCCTCA	0.547000													17	26					0	0	1	0	0
CAPN3	825	broad.mit.edu	37	15	42681141	42681141	+	Silent	SNP	C	C	T	rs138846390	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42681141C>T	ENST00000397163.3	+	5	867	c.648C>T	c.(646-648)taC>taT	p.Y216Y	RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000357568.3_Silent_p.Y216Y|CAPN3_ENST00000318023.7_Silent_p.Y216Y|CAPN3_ENST00000349748.3_Silent_p.Y216Y|CAPN3_ENST00000356316.3_Silent_p.Y129Y	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	216	Calpain catalytic.		Missing (in LGMD2A).		muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		ATGGTTCCTACGAAGCTCTGA	0.512000													13	71					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120569761	120569761	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:120569761C>T	ENST00000300648.6	-	54	7395	c.7383G>A	c.(7381-7383)gaG>gaA	p.E2461E		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	2461					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGGCACTAAGCTCCTCTTCAG	0.582000													6	12					0	0	1	0	0
TICAM2	353376	broad.mit.edu	37	5	114916571	114916571	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:114916571G>T	ENST00000408996.4	-	4	1276	c.890C>A	c.(889-891)gCt>gAt	p.A297D	TMED7-TICAM2_ENST00000333314.3_3'UTR|TMED7-TICAM2_ENST00000282382.4_Missense_Mutation_p.A297D|TICAM2_ENST00000427199.2_Missense_Mutation_p.A128D	NM_001164468.2|NM_001164469.2	NP_001157940.1|NP_001157941.1			toll-like receptor adaptor molecule 2											cervix(1)|kidney(1)|lung(2)|soft_tissue(1)	5		all_cancers(142;0.0223)|all_epithelial(76;0.000869)|Prostate(80;0.0115)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;4.38e-07)|Epithelial(69;1.62e-06)|all cancers(49;6.93e-05)		CCCATTTACAGCATCATCTAA	0.388000													5	59					1.024e-07	1.07677e-07	1	1	0
PPAN-P2RY11	0	broad.mit.edu	37	19	10220804	10220804	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10220804C>T	ENST00000428358.1	+	8	876	c.704C>T	c.(703-705)gCg>gTg	p.A235V	PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.A235V|PPAN_ENST00000393793.1_Missense_Mutation_p.A182V|PPAN_ENST00000556468.1_Missense_Mutation_p.A235V|PPAN_ENST00000253107.7_Missense_Mutation_p.A235V	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		235	Brix.				RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			CACAGGGGCGCGGGGCTGTCG	0.687000													12	20					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91770187	91770187	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:91770187C>T	ENST00000389857.6	-	20	3579	c.3493G>A	c.(3493-3495)Gag>Aag	p.E1165K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1165					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				AGCAGGGCCTCGTAGGCCGCT	0.642000													18	24					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73076578	73076578	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:73076578C>T	ENST00000263674.3	+	19	6044	c.5694C>T	c.(5692-5694)gaC>gaT	p.D1898D		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1898					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						CAGAAGTAGACGTCACTCCTC	0.582000													17	24					0	0	1	0	0
S100A16	140576	broad.mit.edu	37	1	153580145	153580145	+	Silent	SNP	C	C	T	rs144537408		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:153580145C>T	ENST00000368704.1	-	3	362	c.177G>A	c.(175-177)gcG>gcA	p.A59A	S100A16_ENST00000368703.2_Silent_p.A59A|S100A16_ENST00000368706.4_Silent_p.A59A|S100A16_ENST00000474991.1_5'UTR|S100A16_ENST00000368705.2_Silent_p.A59A			Q96FQ6	S10AG_HUMAN	S100 calcium binding protein A16	59	EF-hand 2.					cytosol|nucleolus	calcium ion binding|protein homodimerization activity			breast(1)|large_intestine(1)|prostate(1)	3	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGAGCTTATCCGCAGCCTTCC	0.592000													23	23					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61496403	61496403	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61496403G>A	ENST00000257215.5	+	8	888	c.771_splice	c.e8-1	p.A258_splice		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	258					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		GGTCTTACAGGCAAACAATGA	0.577000													12	22					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32211077	32211077	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:32211077A>G	ENST00000346541.3	+	6	1231	c.694A>G	c.(694-696)Aat>Gat	p.N232D	CBFA2T2_ENST00000359606.3_Missense_Mutation_p.N242D|CBFA2T2_ENST00000375279.2_Missense_Mutation_p.N232D|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.N203D|CBFA2T2_ENST00000397798.2_Missense_Mutation_p.N203D|CBFA2T2_ENST00000491618.1_3'UTR|CBFA2T2_ENST00000342704.5_Missense_Mutation_p.N223D|CBFA2T2_ENST00000344201.3_Missense_Mutation_p.N203D	NM_005093.3	NP_005084.1	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	232						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						GGTGCACGGAAATGGGAAGAG	0.552000													11	18					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3779041	3779041	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3779041G>A	ENST00000262367.5	-	31	6816	c.6007C>T	c.(6007-6009)Ccc>Tcc	p.P2003S	CREBBP_ENST00000382070.3_Missense_Mutation_p.P1965S	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	2003					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TTGGGTCGGGGCACATTCAGG	0.697000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						6	6					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33031411	33031411	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:33031411A>G	ENST00000340811.4	-	3	511	c.403T>C	c.(403-405)Tcc>Ccc	p.S135P	PKP2_ENST00000070846.6_Missense_Mutation_p.S135P	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	135					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TCTTCCACGGACTTCTGGGAG	0.532000													5	185					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33135305	33135305	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:33135305G>A	ENST00000306065.4	-	5	609	c.451C>T	c.(451-453)Cga>Tga	p.R151*	ANKRD27_ENST00000587352.1_Nonsense_Mutation_p.R151*|ANKRD27_ENST00000586693.2_5'UTR	NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	151					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					CTGTCAAATCGCTCGGAGTGT	0.493000													55	214					0	0	1	0	0
MVP	9961	broad.mit.edu	37	16	29853338	29853338	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:29853338G>A	ENST00000357402.5	+	10	1677	c.1539G>A	c.(1537-1539)gcG>gcA	p.A513A	MVP_ENST00000395353.1_Silent_p.A513A	NM_005115.4|NM_017458.3	NP_005106.2|NP_059447.2	Q14764	MVP_HUMAN	major vault protein	513					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(7)|ovary(2)|skin(3)|soft_tissue(1)|stomach(1)	27						CCCGCCGTGCGCTCTGCCTGC	0.622000													17	18					0	0	1	0	0
KRT10	3858	broad.mit.edu	37	17	38975947	38975947	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38975947G>A	ENST00000269576.5	-	6	1204	c.1195C>T	c.(1195-1197)Cgc>Tgc	p.R399C	TMEM99_ENST00000496847.1_Intron|TMEM99_ENST00000301665.3_Intron	NM_000421.3	NP_000412.3	P13645	K1C10_HUMAN	keratin 10	399	Coil 2.|Gly-rich.|Rod.				epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				ACACAGTAGCGACCTTCTGTT	0.468000													7	52					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23528662	23528662	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23528662G>A	ENST00000262710.1	-	19	4048	c.3721C>T	c.(3721-3723)Cgg>Tgg	p.R1241W	ACIN1_ENST00000338631.6_Missense_Mutation_p.R514W|ACIN1_ENST00000397341.3_Missense_Mutation_p.R483W|ACIN1_ENST00000557515.1_Missense_Mutation_p.R482W|ACIN1_ENST00000605057.1_Missense_Mutation_p.R1183W|ACIN1_ENST00000457657.1_Missense_Mutation_p.R1201W|ACIN1_ENST00000357481.2_Missense_Mutation_p.R483W|ACIN1_ENST00000555053.1_Missense_Mutation_p.R1228W	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1241	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CGTTCGGCCCGCTCTGCCTCT	0.592000													24	29					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119044644	119044644	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:119044644T>C	ENST00000409109.1	+	5	1273	c.686T>C	c.(685-687)cTg>cCg	p.L229P	NLRX1_ENST00000525863.1_Missense_Mutation_p.L229P|NLRX1_ENST00000409991.1_Missense_Mutation_p.L229P|NLRX1_ENST00000409265.4_Missense_Mutation_p.L229P|NLRX1_ENST00000292199.2_Missense_Mutation_p.L229P			Q86UT6	NLRX1_HUMAN	NLR family member X1	229	NACHT.|Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GTTCTGCCCCTGATGGCTGCT	0.632000													3	16					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62396361	62396361	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62396361C>T	ENST00000346178.4	-	18	2141	c.2126G>A	c.(2125-2127)tGg>tAg	p.W709*	GANAB_ENST00000534779.1_Nonsense_Mutation_p.W595*|GANAB_ENST00000356638.3_Nonsense_Mutation_p.W687*|GANAB_ENST00000540933.1_Nonsense_Mutation_p.W590*	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	687					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						TGGTAACAGCCATGGCTCTCG	0.552000													27	64					0	0	1	0	0
FAM83H	286077	broad.mit.edu	37	8	144808312	144808312	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144808312G>A	ENST00000388913.3	-	5	3444	c.3319C>T	c.(3319-3321)Cgc>Tgc	p.R1107C		NM_198488.3	NP_940890.3	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	1107					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GGCAGCGTGCGGCTCAGCCGG	0.667000													7	7					0	0	1	0	0
SYNPR	132204	broad.mit.edu	37	3	63429127	63429127	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:63429127T>C	ENST00000295894.5	+	1	375	c.6T>C	c.(4-6)tgT>tgC	p.C2C	SYNPR_ENST00000479198.1_Silent_p.C2C|SYNPR-AS1_ENST00000488201.1_RNA|SYNPR_ENST00000478744.1_3'UTR|SYNPR_ENST00000465156.1_Silent_p.C2C|SYNPR_ENST00000478300.1_Intron|SYNPR_ENST00000460711.1_Silent_p.C2C	NM_144642.4	NP_653243.1	Q8TBG9	SYNPR_HUMAN	synaptoporin	2	MARVEL.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		TGTAAATGTGTATGGTGATAT	0.403000													3	2					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47882389	47882389	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47882389G>A	ENST00000446256.2	+	8	844	c.272G>A	c.(271-273)cGg>cAg	p.R91Q	DHX30_ENST00000445061.1_Missense_Mutation_p.R130Q|DHX30_ENST00000348968.4_Missense_Mutation_p.R102Q|DHX30_ENST00000457607.1_Missense_Mutation_p.R158Q	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	130	DRBM.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CTAGGTCCCCGGAATGAGTTG	0.577000													8	46					0	0	1	0	0
SSH2	85464	broad.mit.edu	37	17	27963743	27963743	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27963743G>T	ENST00000269033.3	-	14	1575	c.1424C>A	c.(1423-1425)cCt>cAt	p.P475H	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Missense_Mutation_p.P502H	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	475					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TTCTAGCCCAGGTTTGCAGAT	0.498000													44	79					1.19451e-25	1.33414e-25	1	1	0
RALYL	138046	broad.mit.edu	37	8	85799885	85799885	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:85799885G>T	ENST00000521268.1	+	8	1837	c.732G>T	c.(730-732)gaG>gaT	p.E244D	RALYL_ENST00000521695.1_Missense_Mutation_p.E244D|RALYL_ENST00000518566.1_Missense_Mutation_p.E233D|RALYL_ENST00000521376.1_Intron|RALYL_ENST00000517638.1_Missense_Mutation_p.E257D|RALYL_ENST00000523850.1_Missense_Mutation_p.E171D|RALYL_ENST00000522455.1_Missense_Mutation_p.E244D	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	244							identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						TGATCCAAGAGGAATGTGTGT	0.502000													31	47					3.80469e-20	4.21587e-20	1	1	0
DR1	1810	broad.mit.edu	37	1	93812396	93812396	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:93812396C>T	ENST00000370272.3	+	1	952	c.194C>T	c.(193-195)aCc>aTc	p.T65I	DR1_ENST00000370267.1_Missense_Mutation_p.T65I	NM_001938.2	NP_001929.1	Q01658	NC2B_HUMAN	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	65					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex	sequence-specific DNA binding|TBP-class protein binding|transcription corepressor activity			endometrium(3)|large_intestine(1)	4		all_lung(203;0.00252)|Lung NSC(277;0.011)|Melanoma(281;0.155)		all cancers(265;0.0032)|GBM - Glioblastoma multiforme(16;0.0165)|Epithelial(280;0.0977)		GAAAAGAAGACCATCTCACCA	0.463000													12	19					0	0	1	0	0
DDX5	1655	broad.mit.edu	37	17	62496410	62496410	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62496410G>A	ENST00000225792.5	-	13	1877	c.1476C>T	c.(1474-1476)gaC>gaT	p.D492D	DDX5_ENST00000578804.1_Silent_p.D492D|DDX5_ENST00000580026.1_5'UTR|DDX5_ENST00000450599.2_Silent_p.D413D	NM_004396.3	NP_004387.1	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 5	492					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	19	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			TGTCCCGACGGTCATCCTTCA	0.423000			T	ETV4	prostate								34	52					0	0	1	0	0
CCDC155	147872	broad.mit.edu	37	19	49897812	49897812	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49897812C>T	ENST00000447857.3	+	3	328	c.123C>T	c.(121-123)ttC>ttT	p.F41F		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	41						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						ACTCCACGTTCGAAGCTTGTG	0.637000													23	50					0	0	1	0	0
PCDHGA1	0	broad.mit.edu	37	5	140711852	140711852	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140711852C>T	ENST00000517417.1	+	1	1601	c.1601C>T	c.(1600-1602)gCg>gTg	p.A534V	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.A534V	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAGTGATGGCGCGGGACAGT	0.597000													44	83					0	0	1	0	0
CRYL1	51084	broad.mit.edu	37	13	20987517	20987517	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:20987517C>T	ENST00000382812.1	-	7	805	c.577G>A	c.(577-579)Gtg>Atg	p.V193M	CRYL1_ENST00000298248.7_Missense_Mutation_p.V215M			Q9Y2S2	CRYL1_HUMAN	crystallin, lambda 1	215					fatty acid metabolic process	cytosol	3-hydroxyacyl-CoA dehydrogenase activity|L-gulonate 3-dehydrogenase activity|NAD+ binding|protein homodimerization activity			NS(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(29;2.27e-23)|all_epithelial(30;1.69e-19)|all_lung(29;8.29e-18)|Lung SC(185;0.0262)|Ovarian(182;0.0827)|Hepatocellular(188;0.244)		all cancers(112;6.6e-05)|Epithelial(112;0.00178)|OV - Ovarian serous cystadenocarcinoma(117;0.0169)|Lung(94;0.0215)|GBM - Glioblastoma multiforme(144;0.0402)|LUSC - Lung squamous cell carcinoma(192;0.061)		CTAGGAGACACGATTCCTTCC	0.463000													5	13					0	0	1	0	0
RAD54L	8438	broad.mit.edu	37	1	46726956	46726956	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:46726956G>A	ENST00000371975.4	+	8	1464	c.790G>A	c.(790-792)Gcc>Acc	p.A264T	RAD54L_ENST00000442598.1_Missense_Mutation_p.A264T	NM_003579.3	NP_003570.2	Q92698	RAD54_HUMAN	RAD54-like (S. cerevisiae)	264	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	25	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		CCAGCGTGGAGCCAGGGTGTC	0.408000								Direct reversal of damage;Homologous recombination					41	42					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5661677	5661677	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5661677C>T	ENST00000292123.5	+	15	2118	c.2011C>T	c.(2011-2013)Cgc>Tgc	p.R671C	SAFB_ENST00000454510.1_Missense_Mutation_p.R602C|SAFB_ENST00000592224.1_Missense_Mutation_p.R670C|SAFB_ENST00000538656.1_Missense_Mutation_p.R513C|SAFB_ENST00000588852.1_Missense_Mutation_p.R671C|SAFB_ENST00000433404.1_Missense_Mutation_p.R501C	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	671	Arg-rich.|Glu-rich.|Interaction with POLR2A.|Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		ACGGCTGGAGCGCGAACGCAT	0.701000													5	6					0	0	1	0	0
NDUFS3	4722	broad.mit.edu	37	11	47606018	47606018	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:47606018G>A	ENST00000263774.4	+	7	862	c.780G>A	c.(778-780)aaG>aaA	p.K260K	NDUFS3_ENST00000533507.1_3'UTR	NM_004551.2	NP_004542.1	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	260					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	GAGACAAGAAGCCTGATGCCA	0.512000													9	78					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144863353	144863353	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:144863353T>C	ENST00000369359.4	-	40	6496	c.6458A>G	c.(6457-6459)gAg>gGg	p.E2153G	PDE4DIP_ENST00000530740.1_Missense_Mutation_p.E2102G|RP4-791M13.4_ENST00000532137.1_RNA|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.E2017G|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.E1911G|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.E2017G|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2017					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATAAAGTGCCTCGTAGATTTG	0.502000			T	PDGFRB	MPD								5	120					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35539724	35539724	+	Silent	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:35539724A>T	ENST00000262878.4	-	11	1366	c.1167T>A	c.(1165-1167)gcT>gcA	p.A389A		NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	389					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				CTTTGAGGAAAGCATCTGTAA	0.333000													36	47					0	0	1	0	0
MLPH	79083	broad.mit.edu	37	2	238434378	238434378	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:238434378C>T	ENST00000264605.3	+	7	1104	c.810C>T	c.(808-810)caC>caT	p.H270H	MLPH_ENST00000468178.1_3'UTR|MLPH_ENST00000445024.2_Silent_p.H270H|MLPH_ENST00000338530.4_Silent_p.H270H|MLPH_ENST00000410032.1_Intron|MLPH_ENST00000409373.1_Silent_p.H230H	NM_024101.5	NP_077006.1	Q9BV36	MELPH_HUMAN	melanophilin	270							metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(3)|large_intestine(2)|lung(11)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	25		Breast(86;0.000381)|Renal(207;0.000966)|Ovarian(221;0.0695)|all_hematologic(139;0.095)|all_lung(227;0.17)|Melanoma(123;0.203)		Epithelial(121;1.17e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.02e-10)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.15e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000439)|Lung(119;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0316)		CTTCCAGACACGGCGCCCTGG	0.667000													13	31					0	0	1	0	0
ZNF615	284370	broad.mit.edu	37	19	52496341	52496341	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:52496341C>T	ENST00000602063.1	-	6	2337	c.1988G>A	c.(1987-1989)cGc>cAc	p.R663H	ZNF615_ENST00000598071.1_Missense_Mutation_p.R674H|ZNF615_ENST00000594083.1_Missense_Mutation_p.R674H|ZNF615_ENST00000391795.3_Missense_Mutation_p.R668H|ZNF615_ENST00000376716.5_Missense_Mutation_p.R663H			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	663					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		ATCATTTTTGCGCAAAGAGAA	0.408000													7	154					0	0	1	0	0
PPP1R11	6992	broad.mit.edu	37	6	30036998	30036998	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30036998G>A	ENST00000376772.3	+	3	619	c.296G>A	c.(295-297)cGt>cAt	p.R99H	PPP1R11_ENST00000376765.2_Missense_Mutation_p.R47H|PPP1R11_ENST00000376763.1_Missense_Mutation_p.R47H|PPP1R11_ENST00000376758.1_Missense_Mutation_p.R47H|PPP1R11_ENST00000376769.2_Missense_Mutation_p.R47H|PPP1R11_ENST00000376773.1_Missense_Mutation_p.R47H	NM_021959.2	NP_068778.1	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 11	99						soluble fraction	protein binding|protein phosphatase inhibitor activity			lung(2)|ovary(1)|prostate(1)|skin(2)	6						AAAGGACGGCGTCGTGCAACC	0.622000													23	25					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111419366	111419366	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:111419366G>A	ENST00000535254.1	-	9	1017	c.950C>T	c.(949-951)gCg>gTg	p.A317V	BUB1_ENST00000302759.6_Missense_Mutation_p.A337V|BUB1_ENST00000409311.1_Missense_Mutation_p.A337V	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	337					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		AAGACATGGCGCTCTCAGTTC	0.453000													27	44					0	0	1	0	0
DGKZ	8525	broad.mit.edu	37	11	46401088	46401088	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46401088C>T	ENST00000454345.1	+	31	3332	c.3207C>T	c.(3205-3207)gcC>gcT	p.A1069A	DGKZ_ENST00000395574.3_Silent_p.A847A|DGKZ_ENST00000543978.1_Silent_p.A233A|DGKZ_ENST00000318201.8_Silent_p.A858A|DGKZ_ENST00000343674.6_Silent_p.A897A|DGKZ_ENST00000421244.2_Silent_p.A881A|DGKZ_ENST00000528615.1_Silent_p.A659A|DGKZ_ENST00000527911.1_Silent_p.A886A|DGKZ_ENST00000532868.2_Silent_p.A885A|DGKZ_ENST00000456247.2_Silent_p.A880A	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	1069					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TCGTGGAGGCCGGGGCCTCGC	0.667000													6	3					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2057240	2057240	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:2057240G>A	ENST00000262113.4	+	25	3239	c.3098G>A	c.(3097-3099)cGc>cAc	p.R1033H	MYOM2_ENST00000523438.1_Missense_Mutation_p.R458H	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1033					muscle contraction	myosin filament	structural constituent of muscle	p.R1033H(1)		autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GGGCGGGTTCGCTTCTGGCTC	0.443000													36	33					0	0	1	0	0
FASTKD1	79675	broad.mit.edu	37	2	170417105	170417105	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:170417105C>T	ENST00000453153.2	-	5	1109	c.763G>A	c.(763-765)Gta>Ata	p.V255I	FASTKD1_ENST00000453929.2_Missense_Mutation_p.V255I	NM_024622.3	NP_078898.3	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	255					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(5)|large_intestine(10)|lung(9)|ovary(4)|prostate(3)	37						CTTAAAAATACGTTATTACAT	0.289000													21	28					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43540349	43540349	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:43540349G>A	ENST00000395891.1	+	20	4094	c.3489G>A	c.(3487-3489)ttG>ttA	p.L1163L	HECW1_ENST00000453890.1_Silent_p.L1129L	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1163					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TTGAGAAGTTGTCCTGTGATG	0.488000													27	48					0	0	1	0	0
WDR63	126820	broad.mit.edu	37	1	85551600	85551600	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:85551600C>A	ENST00000294664.6	+	7	807	c.627C>A	c.(625-627)gcC>gcA	p.A209A	WDR63_ENST00000370596.1_Silent_p.A209A|WDR63_ENST00000326813.8_Silent_p.A209A	NM_145172.3	NP_660155.2	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	209										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)	36				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TAAAAGATGCCTATATTGAAT	0.353000													22	30					1.10513e-12	1.19686e-12	1	1	0
WDR24	84219	broad.mit.edu	37	16	737159	737159	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:737159C>T	ENST00000293883.4	-	3	1676	c.917G>A	c.(916-918)cGc>cAc	p.R306H	WDR24_ENST00000248142.6_Missense_Mutation_p.R436H	NM_032259.2	NP_115635.1	Q96S15	WDR24_HUMAN	WD repeat domain 24	436										breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(3)	19		Hepatocellular(780;0.0218)				GTGGGGGTGGCGCCAGGCAAT	0.647000													5	12					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5564752	5564752	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:5564752G>A	ENST00000310917.2	-	22	4241	c.3510C>T	c.(3508-3510)ggC>ggT	p.G1170G	EVC2_ENST00000344938.1_Intron|EVC2_ENST00000344408.5_Silent_p.G1250G	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	1250						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						GGGCCAGTTCGCCAATGGGCT	0.443000													29	109					0	0	1	0	0
DFFA	1676	broad.mit.edu	37	1	10523635	10523635	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:10523635G>A	ENST00000377038.3	-	4	551	c.484C>T	c.(484-486)Cgt>Tgt	p.R162C	DFFA_ENST00000377036.2_Missense_Mutation_p.R162C	NM_004401.2	NP_004392.1	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha polypeptide	162					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding			large_intestine(3)|lung(2)	5	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		CAACTCTGACGTAGTTCCTGA	0.507000													44	68					0	0	1	0	0
FURIN	5045	broad.mit.edu	37	15	91424578	91424578	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:91424578G>A	ENST00000268171.3	+	16	2134	c.1855G>A	c.(1855-1857)Gcc>Acc	p.A619T		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	619	Cys-rich.				cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity	p.Q621fs*8(1)		breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TCCAGGGTTCGCCCCCCAAGT	0.632000													17	25					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5204939	5204939	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:5204939G>A	ENST00000334314.3	-	2	214	c.138C>T	c.(136-138)gaC>gaT	p.D46D						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						GGAAGCCTACGTCAATAGCCA	0.473000													43	56					0	0	1	0	0
LAG3	3902	broad.mit.edu	37	12	6886538	6886538	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6886538C>T	ENST00000203629.2	+	6	1499	c.1166C>T	c.(1165-1167)tCc>tTc	p.S389F		NM_002286.5	NP_002277.4	P18627	LAG3_HUMAN	lymphocyte-activation gene 3	389	Ig-like C2-type 3.					integral to membrane	antigen binding|MHC class II protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						GACACCCCATCCCAGAGGAGT	0.572000													12	51					0	0	1	0	0
SPEM1	374768	broad.mit.edu	37	17	7324875	7324875	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7324875C>T	ENST00000323675.3	+	3	906	c.881C>T	c.(880-882)gCc>gTc	p.A294V	RP11-104H15.7_ENST00000575310.1_RNA	NM_199339.2	NP_955371.2	Q8N4L4	SPEM1_HUMAN	spermatid maturation 1	294					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	12		Prostate(122;0.173)				TCCAGCACTGCCGAGGAGACA	0.582000													5	6					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62415761	62415761	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62415761C>T	ENST00000330574.2	-	2	1843	c.1791G>A	c.(1789-1791)gcG>gcA	p.A597A		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	597					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						CCCCAAAGTGCGCCCCTAGGG	0.622000													8	25					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935424	30935424	+	Missense_Mutation	SNP	G	G	A	rs142265762		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:30935424G>A	ENST00000355537.3	+	2	1102	c.955G>A	c.(955-957)Gtg>Atg	p.V319M		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	319					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.V319L(1)|p.V319M(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CATCAGCCACGTGGAGAAGGC	0.667000													26	62					0	0	1	0	0
FOLR3	2352	broad.mit.edu	37	11	71850454	71850454	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:71850454C>T	ENST00000445078.2	+	4	612	c.541C>T	c.(541-543)Cgc>Tgc	p.R181C	FOLR3_ENST00000456237.1_Missense_Mutation_p.R183C|FOLR3_ENST00000442948.2_Missense_Mutation_p.R140C			P41439	FOLR3_HUMAN	folate receptor 3 (gamma)	139					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity			large_intestine(3)|lung(8)|prostate(2)	13					Folic Acid(DB00158)	GGACTGTGAGCGCTGGTGGGA	0.562000													11	7					0	0	1	0	0
SPTLC2	9517	broad.mit.edu	37	14	78023436	78023436	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:78023436G>A	ENST00000216484.2	-	7	1097	c.904C>T	c.(904-906)Cgg>Tgg	p.R302W		NM_004863.3	NP_004854.1	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base subunit 2	302						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(5)	19			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CTTCGTGTCCGAGGCTGACCA	0.413000													20	32					0	0	1	0	0
IFT88	8100	broad.mit.edu	37	13	21199953	21199953	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:21199953G>A	ENST00000382778.4	+	16	2409	c.1291G>A	c.(1291-1293)Gca>Aca	p.A431T	IFT88_ENST00000461115.1_3'UTR|IFT88_ENST00000319980.6_Missense_Mutation_p.A431T|IFT88_ENST00000351808.5_Missense_Mutation_p.A422T|IFT88_ENST00000537103.1_Missense_Mutation_p.A403T			Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog (Chlamydomonas)	431					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	27		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		AATAAACAAAGCAGTTACATA	0.318000													17	18					0	0	1	0	0
EFHD2	79180	broad.mit.edu	37	1	15736730	15736730	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:15736730A>G	ENST00000375980.4	+	1	340	c.263A>G	c.(262-264)gAg>gGg	p.E88G		NM_024329.5	NP_077305.2	Q96C19	EFHD2_HUMAN	EF-hand domain family, member D2	88						membrane raft				large_intestine(1)|skin(1)	2		Renal(390;0.00145)|Breast(348;0.00173)|Colorectal(325;0.00215)|all_lung(284;0.00366)|Lung NSC(340;0.00395)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)|Hepatocellular(190;0.152)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.59e-07)|COAD - Colon adenocarcinoma(227;3.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000119)|KIRC - Kidney renal clear cell carcinoma(229;0.00251)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		GAGTTCAAGGAGTTCTCCAGG	0.682000													11	14					0	0	1	0	0
FAM21C	253725	broad.mit.edu	37	10	46233431	46233431	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:46233431C>T	ENST00000336378.4	+	4	410	c.291_splice	c.e4-1	p.R98_splice	FAM21C_ENST00000540872.1_Splice_Site_p.R98_splice|FAM21C_ENST00000359860.4_Splice_Site_p.R42_splice|FAM21C_ENST00000374362.2_Splice_Site_p.R98_splice|FAM21C_ENST00000537517.1_Splice_Site_p.R98_splice	NM_015262.2	NP_056077.2	A8K5W5	A8K5W5_HUMAN	family with sequence similarity 21, member C	98										central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						CCATATTTAGCGTGTATATGA	0.378000													21	33					0	0	1	0	0
ZNF211	0	broad.mit.edu	37	19	58152510	58152510	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58152510C>T	ENST00000544273.1	+	5	1019	c.692C>T	c.(691-693)gCg>gTg	p.A231V	ZNF211_ENST00000299871.5_Missense_Mutation_p.A284V|ZNF211_ENST00000391703.3_Missense_Mutation_p.A158V|ZNF211_ENST00000541801.1_Missense_Mutation_p.A210V|ZNF211_ENST00000347302.3_Missense_Mutation_p.A219V|ZNF211_ENST00000254182.7_Missense_Mutation_p.A210V|ZNF211_ENST00000240731.4_Missense_Mutation_p.A232V|ZNF211_ENST00000420680.1_Missense_Mutation_p.A223V			Q13398	ZN211_HUMAN	zinc finger protein 211	219						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A232V(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AACAAGTGTGCGGTGGCCTTT	0.473000													12	49					0	0	1	0	0
GPR162	27239	broad.mit.edu	37	12	6935455	6935455	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6935455G>T	ENST00000311268.3	+	4	1939	c.1152G>T	c.(1150-1152)caG>caT	p.Q384H	GPR162_ENST00000428545.2_Missense_Mutation_p.Q100H|GPR162_ENST00000382315.3_Missense_Mutation_p.Q80H	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	384						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						ACCCCGCCCAGGTGAAGCTGC	0.577000											OREG0021636	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	21					0.00400662	0.00405773	1	1	0
PIWIL2	55124	broad.mit.edu	37	8	22211821	22211821	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22211821G>A	ENST00000356766.6	+	22	2843	c.2695G>A	c.(2695-2697)Ggc>Agc	p.G899S	PIWIL2_ENST00000521356.1_Intron|PIWIL2_ENST00000454009.2_Missense_Mutation_p.G899S	NM_018068.3	NP_060538.2	Q8TC59	PIWL2_HUMAN	piwi-like RNA-mediated gene silencing 2	899	Piwi.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		TGTACGGCAGGGCTGTGGCAT	0.478000													36	62					0	0	1	0	0
STX16	8675	broad.mit.edu	37	20	57246283	57246283	+	Missense_Mutation	SNP	G	G	A	rs148806774		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:57246283G>A	ENST00000371141.4	+	7	1446	c.722G>A	c.(721-723)cGc>cAc	p.R241H	STX16-NPEPL1_ENST00000530122.1_Missense_Mutation_p.R241H|STX16_ENST00000359617.4_Missense_Mutation_p.R188H|STX16_ENST00000358029.4_Missense_Mutation_p.R237H|STX16_ENST00000361830.3_Missense_Mutation_p.R241H|STX16_ENST00000361770.5_Missense_Mutation_p.R224H|STX16_ENST00000496003.1_Intron|STX16_ENST00000355957.5_Missense_Mutation_p.R224H|STX16_ENST00000371132.4_Missense_Mutation_p.R220H	NM_001001433.2	NP_001001433.1	O14662	STX16_HUMAN	syntaxin 16	241	t-SNARE coiled-coil homology.				intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			breast(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(1)	17	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			CGAGAGATTCGCCAGATTGTA	0.488000													21	34					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14105419	14105419	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:14105419C>T	ENST00000235372.7	+	8	1985	c.1129C>T	c.(1129-1131)Cgt>Tgt	p.R377C	PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000311066.5_Missense_Mutation_p.R377C|PRDM2_ENST00000343137.4_Missense_Mutation_p.R176C|PRDM2_ENST00000413440.1_Missense_Mutation_p.R176C|PRDM2_ENST00000376048.5_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	377						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GGGGCTTGAGCGTCACATGCA	0.453000													22	40					0	0	1	0	0
SEC16A	9919	broad.mit.edu	37	9	139370681	139370681	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139370681C>A	ENST00000313050.7	-	1	1460	c.1387G>T	c.(1387-1389)Gaa>Taa	p.E463*	SEC16A_ENST00000431893.2_Nonsense_Mutation_p.E285*|SEC16A_ENST00000290037.6_Nonsense_Mutation_p.E285*|SEC16A_ENST00000371706.3_Nonsense_Mutation_p.E285*	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	285					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		TGAACAAATTCTAAGTTCTCA	0.562000													4	57					0.00024832	0.000253518	1	1	0
DNAH5	1767	broad.mit.edu	37	5	13841205	13841205	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:13841205C>T	ENST00000265104.4	-	34	5623	c.5519G>A	c.(5518-5520)cGg>cAg	p.R1840Q		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1840	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTCTGAATCCCGTGTCCATAT	0.328000									Kartagener syndrome				27	47					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152815040	152815040	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:152815040C>T	ENST00000370186.1	+	9	1708	c.1382C>T	c.(1381-1383)aCg>aTg	p.T461M	ATP2B3_ENST00000370181.2_Missense_Mutation_p.T461M|ATP2B3_ENST00000263519.4_Missense_Mutation_p.T475M|ATP2B3_ENST00000393842.1_Missense_Mutation_p.T461M|ATP2B3_ENST00000349466.2_Missense_Mutation_p.T475M|ATP2B3_ENST00000359149.3_Missense_Mutation_p.T475M			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	475					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCGACAAGACGGGCACGCTC	0.592000													5	19					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62019306	62019306	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62019306G>A	ENST00000435607.1	-	24	4412	c.4336C>T	c.(4336-4338)Ctg>Ttg	p.L1446L	SCN4A_ENST00000578147.1_Silent_p.L1446L	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1446					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	ACACGGAACAGCGTGGGTGAC	0.662000													6	7					0	0	1	0	0
CHAD	1101	broad.mit.edu	37	17	48542708	48542708	+	Missense_Mutation	SNP	C	C	T	rs146998244		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48542708C>T	ENST00000508540.1	-	3	1183	c.1031G>A	c.(1030-1032)cGc>cAc	p.R344H	ACSF2_ENST00000541920.1_Intron|ACSF2_ENST00000502667.1_Intron|ACSF2_ENST00000427954.2_Intron|ACSF2_ENST00000300441.4_Intron|CHAD_ENST00000258969.4_Missense_Mutation_p.R344H|ACSF2_ENST00000504392.1_Intron	NM_001267.2	NP_001258.2	O15335	CHAD_HUMAN	chondroadherin	344	LRRCT.				regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(2)|ovary(2)	15	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CTTGCAGCTGCGGAAGGCGTC	0.607000													14	20					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95103666	95103666	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:95103666A>G	ENST00000371501.4	-	38	4395	c.4273T>C	c.(4273-4275)Tgc>Cgc	p.C1425R	MYOF_ENST00000358334.5_Missense_Mutation_p.C1412R|MYOF_ENST00000359263.4_Missense_Mutation_p.C1425R|MYOF_ENST00000371502.4_Missense_Mutation_p.C1425R			Q9NZM1	MYOF_HUMAN	myoferlin	1425					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						ATGTCCCGGCATGGTGGGGCA	0.423000													23	25					0	0	1	0	0
TMTC4	84899	broad.mit.edu	37	13	101287436	101287436	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:101287436C>T	ENST00000342624.5	-	11	1474	c.1216G>A	c.(1216-1218)Ggc>Agc	p.G406S	TMTC4_ENST00000376234.3_Missense_Mutation_p.G387S|TMTC4_ENST00000462211.1_5'UTR|TMTC4_ENST00000328767.5_Missense_Mutation_p.G276S	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	387						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AATCCCAGGCCCAGAGTAAGG	0.458000													3	3					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78360611	78360611	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78360611G>A	ENST00000582970.1	+	63	14985	c.14842G>A	c.(14842-14844)Gtg>Atg	p.V4948M	CTD-2047H16.4_ENST00000575034.1_RNA|CTD-2047H16.4_ENST00000573394.1_RNA|RNF213_ENST00000336301.6_Missense_Mutation_p.V3021M|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000508628.2_Missense_Mutation_p.V4997M|RNF213_ENST00000427003.3_3'UTR	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CAGAGAGACCGTGCAGGAGTT	0.587000													9	14					0	0	1	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45484894	45484894	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:45484894G>A	ENST00000359600.5	-	14	2995	c.2790C>T	c.(2788-2790)caC>caT	p.H930H		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	930							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					GGATAGTGGTGTGGGATACGG	0.557000											OREG0013450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	16					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208215586	208215586	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:208215586G>A	ENST00000367033.3	-	22	4900	c.4143C>T	c.(4141-4143)cgC>cgT	p.R1381R		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1381					axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		TGCCCCGGTCGCGCATGGAGA	0.587000													18	14					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58107209	58107209	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58107209G>A	ENST00000357272.4	+	20	3270	c.3105G>A	c.(3103-3105)tcG>tcA	p.S1035S	FLNB_ENST00000490882.1_Silent_p.S1035S|FLNB_ENST00000295956.4_Silent_p.S1035S|FLNB_ENST00000493452.1_Silent_p.S866S|FLNB_ENST00000358537.3_Silent_p.S1035S|FLNB_ENST00000429972.2_Silent_p.S1035S|FLNB_ENST00000419752.2_Silent_p.S866S|FLNB_ENST00000348383.5_Silent_p.S1035S			O75369	FLNB_HUMAN	filamin B, beta	1035					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TGGAGGCCTCGCTGCCACCAG	0.572000													32	54					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209785232	209785232	+	Silent	SNP	G	G	A	rs142610896		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:209785232G>A	ENST00000009105.1	+	11	1256	c.1011G>A	c.(1009-1011)ccG>ccA	p.P337P	CAMK1G_ENST00000361322.2_Silent_p.P337P|CAMK1G_ENST00000494990.1_3'UTR			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	337						Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		AGAACAGGCCGCCTGAAACTC	0.597000													19	32					0	0	1	0	0
TAC4	255061	broad.mit.edu	37	17	47925338	47925338	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:47925338G>A	ENST00000334568.4	-	1	41	c.42C>T	c.(40-42)tcC>tcT	p.S14S	TAC4_ENST00000398154.1_Silent_p.S14S|RP11-304F15.3_ENST00000376609.1_RNA|TAC4_ENST00000326219.5_Silent_p.S14S|TAC4_ENST00000352793.2_Silent_p.S14S|TAC4_ENST00000436235.1_Silent_p.S14S	NM_170685.2	NP_733786.2	Q86UU9	TKN4_HUMAN	tachykinin 4 (hemokinin)	14					regulation of blood pressure	extracellular region				breast(1)|large_intestine(1)|lung(3)	5						CAGTGCACACGGACAGCTCCA	0.577000													13	22					0	0	1	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44505965	44505965	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:44505965G>A	ENST00000255152.2	+	2	977	c.768G>A	c.(766-768)gcG>gcA	p.A256A	ZSWIM3_ENST00000454862.2_Silent_p.A250A	NM_080752.3	NP_542790.2	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM-type containing 3	256							zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	35		Myeloproliferative disorder(115;0.0122)				TGCTCAAGGCGGAGACAGTCA	0.527000													28	24					0	0	1	0	0
DPT	1805	broad.mit.edu	37	1	168683472	168683472	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:168683472G>A	ENST00000367817.3	-	2	507	c.418C>T	c.(418-420)Cca>Tca	p.P140S		NM_001937.4	NP_001928.2	Q07507	DERM_HUMAN	dermatopontin	140	2 X 53-55 AA tandem repeats.|3 X 6 AA repeats of D-R-[EQ]-W-[NQK]- [FY].				cell adhesion	extracellular space|proteinaceous extracellular matrix				kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)	12	all_hematologic(923;0.208)					CAGGAATATGGGCACCTCTTG	0.567000													13	12					0	0	1	0	0
GPR45	11250	broad.mit.edu	37	2	105858660	105858660	+	Missense_Mutation	SNP	G	G	T	rs112707014		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:105858660G>T	ENST00000258456.1	+	1	461	c.345G>T	c.(343-345)tgG>tgT	p.W115C		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	115						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						CGCTCTACTGGTTTTTTGTCC	0.627000													9	35					1.12685e-05	1.16601e-05	1	1	0
COL24A1	255631	broad.mit.edu	37	1	86210460	86210460	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:86210460G>T	ENST00000370571.2	-	57	4927	c.4561C>A	c.(4561-4563)Ctg>Atg	p.L1521M	COL24A1_ENST00000436319.1_Missense_Mutation_p.L1500M	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1521	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		AGGTAGTTCAGGGTTTTGAAT	0.368000													22	46					0.000175454	0.00017952	1	1	0
PLEKHO1	51177	broad.mit.edu	37	1	150131408	150131408	+	Missense_Mutation	SNP	G	G	A	rs140096240	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:150131408G>A	ENST00000369124.4	+	6	1198	c.920G>A	c.(919-921)cGg>cAg	p.R307Q	PLEKHO1_ENST00000369126.1_Missense_Mutation_p.R124Q|PLEKHO1_ENST00000025469.6_Missense_Mutation_p.R273Q	NM_016274.4	NP_057358.2	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O member 1	307	Interaction with ATM, CKIP, IFP35 and NMI.					cytoplasm|nucleus|plasma membrane				breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	22	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGCTGTCCCGGATCCAGGAC	0.647000													8	22					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43778104	43778104	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43778104G>A	ENST00000372476.3	+	12	1838	c.1759G>A	c.(1759-1761)Ggg>Agg	p.G587R	TIE1_ENST00000433781.2_Missense_Mutation_p.G232R	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	587	Fibronectin type-III 2.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTGTGGGACGGGACACGGGG	0.692000													10	23					0	0	1	0	0
CNOT2	4848	broad.mit.edu	37	12	70724123	70724123	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:70724123G>A	ENST00000229195.3	+	6	1022	c.443G>A	c.(442-444)gGc>gAc	p.G148D	CNOT2_ENST00000548230.1_3'UTR|CNOT2_ENST00000418359.3_Missense_Mutation_p.G148D	NM_014515.5	NP_055330.1	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	148					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(2)|urinary_tract(1)	20	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			GTTGGTCAGGGCATTGGAATT	0.443000													43	48					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4968093	4968093	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:4968093G>T	ENST00000380373.2	-	1	263	c.238C>A	c.(238-240)Ctg>Atg	p.L80M	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACAGTGGGCAGAGATGATAAA	0.423000													42	56					5.20006e-24	5.79904e-24	1	1	0
MEIS2	4212	broad.mit.edu	37	15	37391664	37391664	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:37391664C>T	ENST00000338564.5	-	2	450	c.4G>A	c.(4-6)Gcg>Acg	p.A2T	MEIS2_ENST00000382766.2_Missense_Mutation_p.A2T|MEIS2_ENST00000561208.1_Missense_Mutation_p.A2T|MEIS2_ENST00000340545.5_Intron|MEIS2_ENST00000219869.9_5'UTR|MEIS2_ENST00000444725.1_Missense_Mutation_p.A2T|MEIS2_ENST00000424352.2_Missense_Mutation_p.A2T|RP11-128A17.1_ENST00000559509.1_RNA|MEIS2_ENST00000559561.1_Missense_Mutation_p.A2T	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	2					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		ACCCTTTGCGCCATCAGTCTG	0.443000													36	56					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53042001	53042001	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53042001C>T	ENST00000309680.3	-	5	1099	c.1078G>A	c.(1078-1080)Gcc>Acc	p.A360T		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	360	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton	p.A360S(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		CTCCTCTGGGCGATCTCCTCA	0.572000													31	59					0	0	1	0	0
CASKIN1	57524	broad.mit.edu	37	16	2228970	2228970	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2228970C>T	ENST00000343516.6	-	19	4224	c.4132G>A	c.(4132-4134)Gcg>Acg	p.A1378T		NM_020764.3	NP_065815.1	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	1378					signal transduction	cytoplasm				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|liver(1)|lung(7)|ovary(4)|prostate(5)|skin(3)	28						GCCAGGCACGCGCTTGTCTCC	0.816000													3	6					0	0	1	0	0
GLCCI1	113263	broad.mit.edu	37	7	8125939	8125939	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:8125939C>T	ENST00000223145.5	+	8	1972	c.1415C>T	c.(1414-1416)gCt>gTt	p.A472V		NM_138426.3	NP_612435.1	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	472										endometrium(4)|large_intestine(4)|lung(13)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	25		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		CTCTTACCTGCTTCTGACCTT	0.498000													6	221					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52539715	52539715	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52539715C>A	ENST00000321725.6	+	15	1689	c.1613C>A	c.(1612-1614)cCt>cAt	p.P538H		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	538	FAS1 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CTGGACGGACCTGGGCCCTTC	0.632000													10	16					2.27111e-07	2.37911e-07	1	1	0
CIRH1A	84916	broad.mit.edu	37	16	69170682	69170682	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:69170682C>T	ENST00000563094.1	+	3	277	c.243C>T	c.(241-243)ggC>ggT	p.G81G	CIRH1A_ENST00000314423.7_Silent_p.G81G|CIRH1A_ENST00000352319.4_Silent_p.G81G			Q969X6	CIR1A_HUMAN	cirrhosis, autosomal recessive 1A (cirhin)	81						nucleolus	protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(108;0.125)		GGCTCAATGGCGAGATTATGG	0.498000													73	108					0	0	1	0	0
TMEM190	147744	broad.mit.edu	37	19	55889218	55889218	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55889218G>A	ENST00000291934.3	+	4	287	c.269G>A	c.(268-270)gGc>gAc	p.G90D	CTD-2105E13.15_ENST00000595064.1_RNA	NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	90						integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		ACGTGCAGCGGCCTCCTCCTC	0.697000													9	16					0	0	1	0	0
C5orf30	90355	broad.mit.edu	37	5	102611808	102611808	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:102611808G>A	ENST00000319933.2	+	3	496	c.188G>A	c.(187-189)gGc>gAc	p.G63D	C5orf30_ENST00000515669.1_Missense_Mutation_p.G63D|C5orf30_ENST00000510890.1_Missense_Mutation_p.G63D	NM_033211.2	NP_149988.1	Q96GV9	CE030_HUMAN	chromosome 5 open reading frame 30	63										NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	9		all_cancers(142;2.22e-05)|all_epithelial(76;9.54e-08)|Prostate(80;0.0174)|Colorectal(57;0.0551)|Ovarian(225;0.11)|Lung NSC(167;0.136)|all_lung(232;0.18)		Epithelial(69;2.84e-14)|COAD - Colon adenocarcinoma(37;0.00762)		TATTTGGTTGGCTTCACGACT	0.557000													13	24					0	0	1	0	0
EN2	2020	broad.mit.edu	37	7	155255122	155255122	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:155255122C>T	ENST00000297375.4	+	2	991	c.742C>T	c.(742-744)Cgc>Tgc	p.R248C		NM_001427.3	NP_001418.2	P19622	HME2_HUMAN	engrailed homeobox 2	248						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(2)	4	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAAGCGGCCGCGCACGGCCTT	0.607000													8	46					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261978	39261978	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39261978C>T	ENST00000391415.1	+	1	395	c.338C>T	c.(337-339)aCc>aTc	p.T113I		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	113	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						TGTGAGACGACCTGCTGCCAC	0.657000													4	14					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50217104	50217104	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50217104G>A	ENST00000216267.8	-	1	1348	c.862C>T	c.(862-864)Cgc>Tgc	p.R288C	BRD1_ENST00000404034.1_Missense_Mutation_p.R288C|BRD1_ENST00000404760.1_Missense_Mutation_p.R288C|BRD1_ENST00000457780.2_Missense_Mutation_p.R288C	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	288					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGACCCCAGCGGTCGTCATCT	0.642000													20	32					0	0	1	0	0
MDGA2	161357	broad.mit.edu	37	14	47343281	47343281	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:47343281C>T	ENST00000426342.1	-	13	2412	c.1666G>A	c.(1666-1668)Gga>Aga	p.G556R	MDGA2_ENST00000399232.2_Missense_Mutation_p.G854R|MDGA2_ENST00000357362.3_Missense_Mutation_p.G556R|MDGA2_ENST00000399222.3_5'UTR|MDGA2_ENST00000439988.2_Missense_Mutation_p.G785R	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	785	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						GCATTAGGTCCTGTATTAGGA	0.348000													42	63					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032763	30032763	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:30032763C>T	ENST00000328224.6	-	2	2696	c.1463G>A	c.(1462-1464)gGg>gAg	p.G488E		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	488						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						GAGGATGACCCCAATGAAGAG	0.527000													11	21					0	0	1	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37033940	37033940	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:37033940G>A	ENST00000322716.5	-	1	855	c.629C>T	c.(628-630)aCc>aTc	p.T210I		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	210						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						GTTGATTATGGTCAGAAGATC	0.517000													27	33					0	0	1	0	0
MFAP1	4236	broad.mit.edu	37	15	44106859	44106859	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:44106859G>A	ENST00000267812.3	-	4	689	c.457C>T	c.(457-459)Cgt>Tgt	p.R153C		NM_005926.2	NP_005917.2	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	153						microfibril				breast(2)|endometrium(1)|kidney(1)|lung(6)|skin(2)|upper_aerodigestive_tract(3)	15		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		GCTCGCTGACGCATCATGCCA	0.453000													5	38					0	0	1	0	0
IFIT1	3434	broad.mit.edu	37	10	91162577	91162577	+	Missense_Mutation	SNP	C	C	T	rs146515241		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:91162577C>T	ENST00000546318.1	+	2	1739	c.452C>T	c.(451-453)gCg>gTg	p.A151V	LIPA_ENST00000371837.1_Intron|IFIT1_ENST00000371804.3_Missense_Mutation_p.A182V	NM_001270928.1|NM_001270929.1|NM_001270930.1	NP_001257857.1|NP_001257858.1|NP_001257859.1	P09914	IFIT1_HUMAN	interferon-induced protein with tetratricopeptide repeats 1	182					cellular response to exogenous dsRNA|intracellular transport of viral proteins in host cell|negative regulation of defense response to virus by host|negative regulation of helicase activity|negative regulation of protein binding|negative regulation of viral genome replication|positive regulation of viral genome replication|response to virus|type I interferon-mediated signaling pathway	cytoplasm	protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	15						GCTGGGTATGCGATCTCTGCC	0.478000													71	83					0	0	1	0	0
RAB11FIP2	22841	broad.mit.edu	37	10	119800026	119800026	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:119800026T>A	ENST00000355624.3	-	2	843	c.404A>T	c.(403-405)gAg>gTg	p.E135V	RP11-354M20.3_ENST00000451610.2_RNA|RAB11FIP2_ENST00000369199.3_Missense_Mutation_p.E135V|RP11-354M20.3_ENST00000417968.3_RNA	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	135					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		GACCTTTATCTCACCCCTGTT	0.333000													7	18					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47865182	47865182	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:47865182C>T	ENST00000396105.1	-	14	4625	c.4379G>A	c.(4378-4380)cGc>cAc	p.R1460H	ZNFX1_ENST00000371752.1_Missense_Mutation_p.R1460H|ZNFX1_ENST00000371754.4_Intron	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1460							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTGCTGACAGCGTTCATGGAA	0.587000													8	11					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156479482	156479482	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:156479482G>A	ENST00000339252.3	-	3	1095	c.563C>T	c.(562-564)aCg>aTg	p.T188M	HAVCR1_ENST00000544197.1_Missense_Mutation_p.T188M|HAVCR1_ENST00000523175.1_Missense_Mutation_p.T188M|HAVCR1_ENST00000425854.1_Missense_Mutation_p.T188M|HAVCR1_ENST00000522693.1_Missense_Mutation_p.T188M	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	183	11 X 6 AA approximate tandem repeats of V-P-T-T-T-T].|Thr-rich.				interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGAACGCTCGTTGTCGTTGA	0.468000													7	311					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	65957793	65957793	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:65957793C>T	ENST00000443035.3	-	30	5461	c.5246G>A	c.(5245-5247)cGc>cAc	p.R1749H	DENND4A_ENST00000431932.2_Missense_Mutation_p.R1706H	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	1706					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						CATACAGTGGCGGGGAATCTG	0.303000													18	30					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109804178	109804178	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109804178C>T	ENST00000271332.3	+	4	4286	c.4225C>T	c.(4225-4227)Cgt>Tgt	p.R1409C		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1409	Laminin G-like 1.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GTACAATGGGCGTTTCAATGA	0.582000													27	43					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193209164	193209164	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:193209164G>A	ENST00000342695.4	-	6	879	c.557C>T	c.(556-558)aCt>aTt	p.T186I	ATP13A4_ENST00000392443.3_Missense_Mutation_p.T186I|ATP13A4_ENST00000295548.3_Missense_Mutation_p.T186I	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	186					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AACATCGATAGTATTAGGCCC	0.363000													30	36					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120871393	120871393	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:120871393G>T	ENST00000273666.6	+	8	1010	c.739G>T	c.(739-741)Gtt>Ttt	p.V247F	STXBP5L_ENST00000471454.1_Missense_Mutation_p.V247F|STXBP5L_ENST00000492541.1_Missense_Mutation_p.V247F|STXBP5L_ENST00000497029.1_Missense_Mutation_p.V247F|STXBP5L_ENST00000472879.1_Missense_Mutation_p.V247F	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	247					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		AGAACTGAGAGTTTATTATGA	0.338000													10	22					3.07112e-06	3.18879e-06	1	1	0
CYP4F11	57834	broad.mit.edu	37	19	16024574	16024574	+	Missense_Mutation	SNP	G	G	A	rs148679944		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16024574G>A	ENST00000402119.3	-	12	1969	c.1543C>T	c.(1543-1545)Cgg>Tgg	p.R515W	CYP4F11_ENST00000248041.7_Missense_Mutation_p.R515W|CYP4F11_ENST00000326742.7_3'UTR	NM_021187.3	NP_067010.3	Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	515					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						GGCTCCACCCGCAGCCAAAGT	0.607000													3	10					0	0	1	0	0
GLI3	2737	broad.mit.edu	37	7	42005853	42005853	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:42005853G>A	ENST00000395925.3	-	15	2902	c.2818C>T	c.(2818-2820)Ccg>Tcg	p.P940S	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	940					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P940T(1)		NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GTCGGCGGCGGCCCTCCTGTG	0.716000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				10	25					0	0	1	0	0
ZNF124	7678	broad.mit.edu	37	1	247320395	247320395	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247320395G>A	ENST00000340684.6	-	4	481	c.343C>T	c.(343-345)Cgc>Tgc	p.R115C	ZNF124_ENST00000491356.1_Intron|ZNF124_ENST00000491848.1_5'UTR|ZNF124_ENST00000543802.2_Missense_Mutation_p.R177C|ZNF124_ENST00000472531.1_Intron	NM_003431.2	NP_003422.2	Q15973	ZN124_HUMAN	zinc finger protein 124	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(3)|urinary_tract(2)	14	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			CATTCATAGCGTTTTTCTCCA	0.418000													13	36					0	0	1	0	0
PCDHGA6	0	broad.mit.edu	37	5	140755558	140755558	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140755558C>T	ENST00000517434.1	+	1	1908	c.1908C>T	c.(1906-1908)gaC>gaT	p.D636D	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACAGAGACGCGCTCAAGC	0.701000													30	26					0	0	1	0	0
GEMIN4	50628	broad.mit.edu	37	17	651194	651194	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:651194G>A	ENST00000576778.1	-	1	1397	c.56C>T	c.(55-57)gCa>gTa	p.A19V	GEMIN4_ENST00000319004.5_Missense_Mutation_p.A30V|GEMIN4_ENST00000437269.1_Missense_Mutation_p.A30V			P57678	GEMI4_HUMAN	gem (nuclear organelle) associated protein 4	30					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		TTCTGCCAGTGCCTTAGGGTG	0.532000													6	13					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64678411	64678411	+	Silent	SNP	G	G	A	rs144361706	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64678411G>A	ENST00000421419.2	-	11	1596	c.1482C>T	c.(1480-1482)gcC>gcT	p.A494A	ATG2A_ENST00000377264.3_Silent_p.A494A			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	494							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						ACAGCTGCACGGCTGTGCCCG	0.662000													9	7					0	0	1	0	0
POGZ	23126	broad.mit.edu	37	1	151396580	151396580	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151396580G>A	ENST00000271715.2	-	9	1682	c.1368C>T	c.(1366-1368)aaC>aaT	p.N456N	POGZ_ENST00000368863.2_Silent_p.N361N|POGZ_ENST00000361398.3_Silent_p.N403N|POGZ_ENST00000392723.1_Silent_p.N403N|POGZ_ENST00000409503.1_Silent_p.N447N|POGZ_ENST00000540984.1_Intron|POGZ_ENST00000491586.1_Silent_p.N403N|POGZ_ENST00000531094.1_Silent_p.N394N	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	456					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CATCGCCCACGTTCTCATTTG	0.507000													5	77					0	0	1	0	0
TEX11	0	broad.mit.edu	37	X	69749738	69749738	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:69749738C>T	ENST00000395889.2	-	30	2832	c.2677G>A	c.(2677-2679)Gcc>Acc	p.A893T	TEX11_ENST00000374320.2_Missense_Mutation_p.A568T|TEX11_ENST00000374333.2_Missense_Mutation_p.A878T|TEX11_ENST00000344304.3_Missense_Mutation_p.A893T	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	893							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					AAACGCAAGGCCAGGCCACAC	0.498000													26	6					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151166251	151166251	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:151166251G>A	ENST00000282466.3	-	4	1517	c.1518C>T	c.(1516-1518)caC>caT	p.H506H		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	506	Ig-like C2-type 1.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCCAATCCACGTGTGGGGTGG	0.483000													5	153					0	0	1	0	0
VARS2	57176	broad.mit.edu	37	6	30882962	30882962	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30882962G>A	ENST00000321897.5	+	2	863	c.231G>A	c.(229-231)agG>agA	p.R77R	VARS2_ENST00000542001.1_5'UTR|VARS2_ENST00000541562.1_Silent_p.R107R|VARS2_ENST00000416670.2_Silent_p.R77R			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	77					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						AGGCCTGGAGGCCTAAGGAGT	0.468000													34	52					0	0	1	0	0
TYW1	55253	broad.mit.edu	37	7	66482879	66482879	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:66482879G>A	ENST00000359626.5	+	6	774	c.610G>A	c.(610-612)Gcg>Acg	p.A204T		NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	204	Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				GATGCTTGGCGCGCATCGTGT	0.507000													27	33					0	0	1	0	0
RYK	6259	broad.mit.edu	37	3	133878153	133878153	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:133878153T>C	ENST00000427044.2	-	15	1683	c.1073A>G	c.(1072-1074)gAc>gGc	p.D358G	RYK_ENST00000296084.4_Missense_Mutation_p.D548G			P34925	RYK_HUMAN	receptor-like tyrosine kinase	544	Protein kinase.				corpus callosum development|positive regulation of MAPKKK cascade|Wnt receptor signaling pathway	cytoplasm|integral to plasma membrane|nucleus	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(1)|ovary(3)	4						CTCGAAGGGGTCAATGTCCAC	0.498000													7	12					0	0	1	0	0
SNHG14	0	broad.mit.edu	37	15	25415789	25415789	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:25415789C>T	ENST00000549301.1	+	0	303				SNHG14_ENST00000553149.1_RNA																							ATTCCTGATGCCCTGGCCTCC	0.637000													17	31					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26589804	26589804	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:26589804C>T	ENST00000376261.3	+	16	2175	c.1672C>T	c.(1672-1674)Cgc>Tgc	p.R558C	GAD2_ENST00000259271.3_Missense_Mutation_p.R558C	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	558					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	CAATTTCTTCCGCATGGTCAT	0.468000													24	88					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109357021	109357021	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:109357021G>A	ENST00000283195.6	+	7	985	c.859G>A	c.(859-861)Gga>Aga	p.G287R		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	287					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						AGAAATGAAAGGACATTTCTA	0.393000													90	131					0	0	1	0	0
RNF216	54476	broad.mit.edu	37	7	5662580	5662580	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:5662580G>A	ENST00000425013.2	-	17	2736	c.2512C>T	c.(2512-2514)Cgg>Tgg	p.R838W	RNF216_ENST00000389902.3_Missense_Mutation_p.R895W|RNF216_ENST00000469375.1_5'UTR	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	838	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding	p.R895W(1)	FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TAGTTGACCCGCACGTTGGGC	0.642000													57	76					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30915393	30915393	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:30915393G>A	ENST00000375712.3	+	7	2064	c.1897G>A	c.(1897-1899)Gtg>Atg	p.V633M	KIF3B_ENST00000418717.2_Missense_Mutation_p.V259M	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	633	Globular.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGTCTCAGCCGTGGGATATAA	0.517000													9	49					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108117552	108117552	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:108117552G>A	ENST00000273353.3	-	36	5181	c.5125C>T	c.(5125-5127)Cgt>Tgt	p.R1709C		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1709						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CTGCGGCCACGCTCTGTCTGC	0.527000													74	113					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150947924	150947924	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150947924C>A	ENST00000261800.5	-	1	581	c.569G>T	c.(568-570)aGg>aTg	p.R190M		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	190	Cadherin 2.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATCTCTGACCTTGTGTTAAA	0.532000													22	37					6.33239e-15	6.92311e-15	1	1	0
SCEL	8796	broad.mit.edu	37	13	78216886	78216886	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:78216886A>G	ENST00000535157.1	+	30	2037	c.1867A>G	c.(1867-1869)Agt>Ggt	p.S623G	SCEL_ENST00000349847.3_Missense_Mutation_p.S665G|SCEL_ENST00000377246.3_Missense_Mutation_p.S645G	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	665	LIM zinc-binding.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		AGCGGGTGATAGTATTTGGAT	0.308000													22	13					0	0	1	0	0
CARS2	79587	broad.mit.edu	37	13	111357885	111357885	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:111357885C>T	ENST00000257347.4	-	2	321	c.258G>A	c.(256-258)gcG>gcA	p.A86A	CARS2_ENST00000535398.1_Intron	NM_024537.2	NP_078813.1	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial (putative)	86					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|prostate(4)|skin(1)	13	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	GGCCAAGGTGCGCATGATCAT	0.368000													18	35					0	0	1	0	0
PCDHAC2	0	broad.mit.edu	37	5	140347577	140347577	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140347577C>A	ENST00000289269.5	+	1	1758	c.1226C>A	c.(1225-1227)cCt>cAt	p.P409H	PCDHA7_ENST00000525929.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		409	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACACTGCCTTTCCGACTG	0.567000													20	43					5.35267e-07	5.59292e-07	1	1	0
POTEE	445582	broad.mit.edu	37	2	131976050	131976050	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:131976050C>T	ENST00000356920.5	+	1	169	c.75C>T	c.(73-75)ggC>ggT	p.G25G	PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_Silent_p.G25G	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	25							ATP binding										GCAAGATGGGCAAGTGGTGCT	0.552000													54	81					0	0	1	0	0
PCDHA13	0	broad.mit.edu	37	5	140263536	140263536	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140263536C>T	ENST00000289272.2	+	1	1683	c.1683C>T	c.(1681-1683)aaC>aaT	p.N561N	PCDHA7_ENST00000525929.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.N561N|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAACGACAACGCTCCGGCGC	0.697000													35	63					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33089255	33089255	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:33089255C>A	ENST00000306065.4	-	29	3107	c.2949G>T	c.(2947-2949)caG>caT	p.Q983H		NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	983					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					GCAGGTTATTCTGTCTCAGTG	0.517000													45	84					8.04919e-23	8.95685e-23	1	1	0
AURKC	6795	broad.mit.edu	37	19	57746642	57746642	+	Missense_Mutation	SNP	C	C	T	rs66797322		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:57746642C>T	ENST00000302804.7	+	7	973	c.787C>T	c.(787-789)Cct>Tct	p.P263S	AURKC_ENST00000599062.1_Missense_Mutation_p.P260S|AURKC_ENST00000415300.2_Missense_Mutation_p.P244S|AURKC_ENST00000448930.1_Missense_Mutation_p.P229S|AURKC_ENST00000598785.1_Missense_Mutation_p.P229S	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	263	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		ACTATCAATGCCTCTGGGGGC	0.527000													5	20					0	0	1	0	0
DKFZP761J1410	0	broad.mit.edu	37	19	11472018	11472018	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11472018C>T	ENST00000251473.5	+	6	893	c.517C>T	c.(517-519)Cca>Tca	p.P173S	DKFZP761J1410_ENST00000591608.1_Missense_Mutation_p.P148S	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					GGGCTGCCTGCCACCTTCTCC	0.706000													10	29					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	4020446	4020446	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4020446A>T	ENST00000381638.2	-	3	638	c.514T>A	c.(514-516)Ttt>Att	p.F172I	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	172							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GACTCTGAAAATATGTCTGTG	0.502000													17	27					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38229572	38229572	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38229572C>T	ENST00000339503.4	-	8	2146	c.1645G>A	c.(1645-1647)Gga>Aga	p.G549R	ZNF573_ENST00000536220.1_Missense_Mutation_p.G519R|ZNF573_ENST00000357309.3_Missense_Mutation_p.G519R|ZNF573_ENST00000590414.2_Missense_Mutation_p.G607R|ZNF573_ENST00000392138.1_Missense_Mutation_p.G520R	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	587					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TAAGGTTTTCCACCAGTATGA	0.388000													41	43					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45784133	45784133	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:45784133G>A	ENST00000397928.1	+	3	836	c.391G>A	c.(391-393)Gtc>Atc	p.V131I	TRPM2_ENST00000397932.2_Missense_Mutation_p.V131I|TRPM2_ENST00000300481.9_Missense_Mutation_p.V131I|TRPM2_ENST00000300482.5_Missense_Mutation_p.V131I	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	131						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TGGCGACATCGTCTTCACGGG	0.577000													21	15					0	0	1	0	0
ALKBH3	221120	broad.mit.edu	37	11	43918781	43918781	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:43918781C>A	ENST00000378840.4	+	7	809	c.404C>A	c.(403-405)cCt>cAt	p.P135H	ALKBH3_ENST00000532410.1_Intron|ALKBH3_ENST00000302708.4_Intron			Q96Q83	ALKB3_HUMAN	alkB, alkylation repair homolog 3 (E. coli)	0					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation	mitochondrion|nucleoplasm	damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(2)|kidney(1)|lung(4)|prostate(1)	8					Vitamin C(DB00126)	aagtcagcacctgtTAGTGGA	0.473000								Direct reversal of damage					18	22					3.41278e-10	3.64137e-10	1	1	0
ERGIC3	51614	broad.mit.edu	37	20	34135185	34135185	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:34135185G>A	ENST00000348547.2	+	5	467	c.390G>A	c.(388-390)acG>acA	p.T130T	ERGIC3_ENST00000447986.1_Silent_p.T130T|ERGIC3_ENST00000357394.4_Silent_p.T130T|ERGIC3_ENST00000279052.6_Silent_p.T130T	NM_015966.2	NP_057050.1	Q9Y282	ERGI3_HUMAN	ERGIC and golgi 3	130					vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)	16	Lung NSC(9;0.00489)|all_lung(11;0.00729)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			TCGAGGTGACGGTGTTTGACC	0.592000													3	13					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66356360	66356360	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:66356360C>T	ENST00000273854.3	-	5	1737	c.1137G>A	c.(1135-1137)ccG>ccA	p.P379P	EPHA5_ENST00000511294.1_Silent_p.P379P|EPHA5_ENST00000354839.4_Silent_p.P379P|EPHA5_ENST00000432638.2_Intron	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	379	Fibronectin type-III 1.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TGTCAGCAGGCGGAATCCATT	0.458000										TSP Lung(17;0.13)			10	20					0	0	1	0	0
NEK4	6787	broad.mit.edu	37	3	52771727	52771727	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52771727G>T	ENST00000233027.5	-	15	2510	c.2308C>A	c.(2308-2310)Cca>Aca	p.P770T	NEK4_ENST00000535191.1_Missense_Mutation_p.P681T|NEK4_ENST00000383721.4_Missense_Mutation_p.P724T	NM_001193533.1|NM_003157.4	NP_001180462.1|NP_003148.2	P51957	NEK4_HUMAN	NIMA-related kinase 4	770					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(10)	26				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TCAGAACCTGGCATAATAGCT	0.348000													15	30					2.23348e-06	2.32236e-06	1	1	0
CCSER2	54462	broad.mit.edu	37	10	86131100	86131100	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:86131100C>T	ENST00000224756.8	+	2	477	c.292C>T	c.(292-294)Cgt>Tgt	p.R98C	CCSER2_ENST00000359979.4_Missense_Mutation_p.R98C|CCSER2_ENST00000372088.2_Missense_Mutation_p.R98C	NM_018999.2	NP_061872.2			coiled-coil serine-rich protein 2																		TCCTGAAAAACGTGTTCCTAC	0.338000													18	18					0	0	1	0	0
MAP2K2	5605	broad.mit.edu	37	19	4110567	4110567	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4110567G>A	ENST00000262948.5	-	3	643	c.390C>T	c.(388-390)atC>atT	p.I130I	MAP2K2_ENST00000394867.4_Silent_p.I33I|MAP2K2_ENST00000599345.1_5'UTR	NM_030662.3	NP_109587.1	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	130	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAAGCCCACGATGTACGGCG	0.617000													10	25					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233744303	233744303	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:233744303G>A	ENST00000264051.3	-	15	2307	c.2029C>T	c.(2029-2031)Cgg>Tgg	p.R677W	NGEF_ENST00000539537.1_Missense_Mutation_p.R400W|NGEF_ENST00000373552.4_Missense_Mutation_p.R585W	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	677					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		TTCTGGGACCGGATCTTGGGA	0.592000													40	63					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123900990	123900990	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:123900990G>A	ENST00000431524.1	+	1	694	c.661G>A	c.(661-663)Gtc>Atc	p.V221I		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V221I(1)		breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TGTGTCCATCGTCTGTTCCAT	0.542000													27	54					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104742610	104742610	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:104742610A>C	ENST00000334877.4	+	17	2699	c.2165A>C	c.(2164-2166)aAa>aCa	p.K722T	KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000311117.3_Missense_Mutation_p.K722T|KMT2E_ENST00000257745.4_Missense_Mutation_p.K722T					lysine (K)-specific methyltransferase 2E																		GCACTTAATAAATGTCCTACC	0.289000													19	42					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367480	234367480	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:234367480C>T	ENST00000366618.3	+	3	746	c.601C>T	c.(601-603)Cga>Tga	p.R201*	SLC35F3_ENST00000366617.3_Nonsense_Mutation_p.R132*	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	132					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TGTGAAGCAGCGATACAGGTA	0.602000													58	75					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118376991	118376991	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118376991C>T	ENST00000534358.1	+	27	10407	c.10384C>T	c.(10384-10386)Ctt>Ttt	p.L3462F	KMT2A_ENST00000389506.5_Missense_Mutation_p.L3459F|KMT2A_ENST00000354520.4_Missense_Mutation_p.L3421F	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A									p.L3459F(1)									GAACCAGCTCCTTGCCAGCAA	0.527000													46	52					0	0	1	0	0
NOL10	79954	broad.mit.edu	37	2	10729320	10729320	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:10729320G>A	ENST00000345985.3	-	18	1653	c.1543C>T	c.(1543-1545)Cgc>Tgc	p.R515C	NOL10_ENST00000381685.5_Missense_Mutation_p.R565C|AC092687.5_ENST00000414538.1_RNA|NOL10_ENST00000538384.1_Missense_Mutation_p.R539C|NOL10_ENST00000542668.1_Missense_Mutation_p.R515C	NM_001261394.1	NP_001248323.1	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	565						nucleolus						Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		AGGAGTCTGCGTTGCTTCCTG	0.507000													19	48					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63534419	63534419	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:63534419C>T	ENST00000307078.5	-	5	1415	c.1102G>A	c.(1102-1104)Gcc>Acc	p.A368T	AXIN2_ENST00000375702.5_Missense_Mutation_p.A368T|CTD-2535L24.2_ENST00000577662.1_3'UTR	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	368	Interaction with GSK3B (By similarity).				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding	p.A368P(1)		NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						GCAAAGGTGGCGGGTTCCACG	0.627000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				17	17					0	0	1	0	0
IFI6	2537	broad.mit.edu	37	1	27994863	27994863	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:27994863C>T	ENST00000361157.6	-	4	299	c.172G>A	c.(172-174)Gcg>Acg	p.A58T	IFI6_ENST00000339145.4_Missense_Mutation_p.A66T|IFI6_ENST00000362020.4_Missense_Mutation_p.A62T	NM_002038.3|NM_022872.2|NM_022873.2	NP_002029.3|NP_075010.1|NP_075011.1	P09912	IFI6_HUMAN	interferon, alpha-inducible protein 6	58					anti-apoptosis|negative regulation of caspase activity|negative regulation of mitochondrial depolarization|release of cytochrome c from mitochondria|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion	protein binding			lung(1)|ovary(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;7.75e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AAGCCCAGCGCGGGCAGCCCG	0.741000													4	1					0	0	1	0	0
CLIP4	79745	broad.mit.edu	37	2	29404659	29404659	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:29404659G>A	ENST00000320081.5	+	16	2273	c.2018G>A	c.(2017-2019)cGc>cAc	p.R673H	CLIP4_ENST00000401617.2_Intron|CLIP4_ENST00000404424.1_Missense_Mutation_p.R673H	NM_024692.4	NP_078968.3	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family, member 4	673	CAP-Gly 3.									endometrium(4)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(1)	26	Acute lymphoblastic leukemia(172;0.155)					GGTGACAAGCGCTATTTCACC	0.488000													32	41					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122854099	122854099	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:122854099C>T	ENST00000264811.5	-	1	513	c.95G>A	c.(94-96)cGc>cAc	p.R32H	TRPC3_ENST00000379645.3_Missense_Mutation_p.R105H|TRPC3_ENST00000513531.1_Missense_Mutation_p.R32H	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	20					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity	p.R32H(1)		NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GCTGGTGCCGCGGTCATTGAA	0.657000													18	34					0	0	1	0	0
PCDHB4	0	broad.mit.edu	37	5	140503186	140503186	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140503186G>A	ENST00000194152.1	+	1	1606	c.1606G>A	c.(1606-1608)Ggt>Agt	p.G536S		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		536	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCAGACCGCGGTTCTCCGGC	0.662000													31	32					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100334249	100334249	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100334249G>A	ENST00000542585.1	+	0	398				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane		p.G84R(1)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GTACCCTAACGGAGGTGAGGG	0.657000													25	37					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51227074	51227074	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:51227074G>A	ENST00000245441.5	-	17	2090	c.1900C>T	c.(1900-1902)Cgc>Tgc	p.R634C	NIN_ENST00000530997.2_Missense_Mutation_p.R634C|NIN_ENST00000453196.1_Missense_Mutation_p.R634C|NIN_ENST00000389868.3_Missense_Mutation_p.R634C|NIN_ENST00000382041.3_Missense_Mutation_p.R634C|NIN_ENST00000382043.4_Missense_Mutation_p.R634C|NIN_ENST00000324330.9_Missense_Mutation_p.R634C	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	634					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TCATAATGGCGCACCTGAAGG	0.443000			T	PDGFRB	MPD								16	25					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479656	4479656	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:4479656C>T	ENST00000237837.1	-	3	754	c.609G>A	c.(607-609)ccG>ccA	p.P203P		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	203					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			AACAGGAGGCCGGGGCCGGGG	0.706000													13	18					0	0	1	0	0
ZNF669	79862	broad.mit.edu	37	1	247267486	247267486	+	Missense_Mutation	SNP	G	G	A	rs148474673	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:247267486G>A	ENST00000343381.6	-	1	188	c.16C>T	c.(16-18)Cgc>Tgc	p.R6C	ZNF669_ENST00000448299.2_Intron|ZNF669_ENST00000366500.1_Intron|ZNF669_ENST00000358785.4_Missense_Mutation_p.R6C|ZNF669_ENST00000366501.1_Intron	NM_024804.2	NP_079080.2	Q96BR6	ZN669_HUMAN	zinc finger protein 669	6					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(2)|lung(6)	17	all_cancers(71;4.09e-05)|all_epithelial(71;6.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0283)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00427)			GAAGCCAGGCGCAGTCCACTC	0.657000													5	17					0	0	1	0	0
PTGER2	5732	broad.mit.edu	37	14	52781866	52781866	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:52781866C>T	ENST00000245457.5	+	1	754	c.600C>T	c.(598-600)taC>taT	p.Y200Y	PTGER2_ENST00000557436.1_Intron	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	200						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	TGCAGCTGTACGCCACCCTGC	0.627000													16	20					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40339294	40339294	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:40339294C>T	ENST00000310169.2	+	3	417	c.278C>T	c.(277-279)aCg>aTg	p.T93M		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	93					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	GCCTATCTCACGTGGGACCGA	0.483000													9	11					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47864562	47864562	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:47864562G>A	ENST00000396105.1	-	14	5245	c.4999C>T	c.(4999-5001)Ctg>Ttg	p.L1667L	ZNFX1_ENST00000371752.1_Silent_p.L1667L|ZNFX1_ENST00000371754.4_Intron	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1667							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTCTCCAGCAGGGCCTTAAGC	0.507000													42	67					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36700195	36700195	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36700195C>A	ENST00000216181.5	-	19	2466	c.2236G>T	c.(2236-2238)Gcc>Tcc	p.A746S		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	746	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						AGCTCCAGGGCTTTTATCTAG	0.602000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				13	22					6.31663e-08	6.64488e-08	1	1	0
C14orf93	60686	broad.mit.edu	37	14	23465326	23465326	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23465326C>T	ENST00000299088.6	-	3	1178	c.749G>A	c.(748-750)cGc>cAc	p.R250H	RP11-298I3.4_ENST00000555294.1_RNA|C14orf93_ENST00000397377.1_Missense_Mutation_p.R70H|C14orf93_ENST00000406429.2_Missense_Mutation_p.R250H|RP11-298I3.4_ENST00000556503.1_RNA|C14orf93_ENST00000341470.4_Missense_Mutation_p.R250H|C14orf93_ENST00000397379.3_Missense_Mutation_p.R250H|C14orf93_ENST00000397382.4_Missense_Mutation_p.R250H	NM_001130708.1|NM_021944.2	NP_001124180.1|NP_068763.2	Q9H972	CN093_HUMAN	chromosome 14 open reading frame 93	250						extracellular region				kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	17	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		GTCCTCAGGGCGGGGTGGTGG	0.607000													27	43					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433743	73433743	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:73433743G>A	ENST00000263666.4	-	10	2088	c.1974C>T	c.(1972-1974)agC>agT	p.S658S	PDZRN3_ENST00000535920.1_Silent_p.S380S|PDZRN3_ENST00000462146.2_Silent_p.S315S|PDZRN3_ENST00000466780.1_Silent_p.S315S|PDZRN3_ENST00000479530.1_Silent_p.S375S	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	658							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		AAGGGGTGGCGCTCTTCACCT	0.652000													16	31					0	0	1	0	0
RAB25	57111	broad.mit.edu	37	1	156038134	156038134	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156038134C>T	ENST00000361084.5	+	3	554	c.313C>T	c.(313-315)Cga>Tga	p.R105*	RAB25_ENST00000487325.1_3'UTR	NM_020387.2	NP_065120.2	P57735	RAB25_HUMAN	RAB25, member RAS oncogene family	105					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	Hepatocellular(266;0.158)|all_neural(408;0.195)					TGTGGTGGAGCGATGGCTGAA	0.572000													33	48					0	0	1	0	0
KCTD1	284252	broad.mit.edu	37	18	24035721	24035721	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:24035721C>T	ENST00000417602.1	-	5	2583	c.2584G>A	c.(2584-2586)Gag>Aag	p.E862K	KCTD1_ENST00000580059.1_Missense_Mutation_p.E254K|KCTD1_ENST00000317932.7_Missense_Mutation_p.E254K|KCTD1_ENST00000408011.3_Missense_Mutation_p.E254K|KCTD1_ENST00000579973.1_Missense_Mutation_p.E254K	NM_001142730.2	NP_001136202.1	Q719H9	KCTD1_HUMAN	potassium channel tetramerization domain containing 1	254					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity	p.E254K(1)|p.E862K(1)		endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(3)	12	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			TCCAGAGGCTCTTGCTTTATC	0.498000													19	35					0	0	1	0	0
NAB2	4665	broad.mit.edu	37	12	57485260	57485260	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57485260G>T	ENST00000300131.3	+	2	814	c.436G>T	c.(436-438)Ggc>Tgc	p.G146C	NAB2_ENST00000554718.1_3'UTR|NAB2_ENST00000357680.4_Missense_Mutation_p.G146C|NAB2_ENST00000342556.6_Missense_Mutation_p.G146C	NM_005967.3	NP_005958.1	Q15742	NAB2_HUMAN	NGFI-A binding protein 2 (EGR1 binding protein 2)	146					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						CAATGGGCATGGCAGCCCAGG	0.602000													26	35					4.22769e-11	4.54161e-11	1	1	0
ODC1	4953	broad.mit.edu	37	2	10584237	10584237	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:10584237C>T	ENST00000234111.4	-	5	943	c.433G>A	c.(433-435)Gca>Aca	p.A145T	ODC1_ENST00000405333.1_Missense_Mutation_p.A145T|ODC1_ENST00000446285.1_5'UTR	NM_002539.1	NP_002530.1	P11926	DCOR_HUMAN	ornithine decarboxylase 1	145					polyamine biosynthetic process|regulation of cellular amino acid metabolic process|response to virus	cytosol	ornithine decarboxylase activity|protein binding			NS(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(3)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.161)	Pyridoxal Phosphate(DB00114)|Spermine(DB00127)	TTGGGATGTGCTCTGGCAACT	0.363000													99	134					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112358653	112358653	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:112358653C>T	ENST00000206423.3	-	2	1053	c.100G>A	c.(100-102)Gga>Aga	p.G34R	CCDC80_ENST00000475181.1_5'UTR|CCDC80_ENST00000439685.2_Missense_Mutation_p.G34R	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	34										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						TTCCGTCCTCCGTGGCTGCCT	0.557000													21	30					0	0	1	0	0
L2HGDH	79944	broad.mit.edu	37	14	50734519	50734519	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:50734519C>A	ENST00000267436.4	-	8	1413	c.1016G>T	c.(1015-1017)aGa>aTa	p.R339I	L2HGDH_ENST00000421284.3_Missense_Mutation_p.R339I|L2HGDH_ENST00000261699.4_Missense_Mutation_p.R339I			Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase	339					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			kidney(1)|large_intestine(4)|lung(3)|ovary(2)	10	all_epithelial(31;0.000599)|Breast(41;0.0102)					GTCAAAGGGTCTGTAACCCTC	0.373000													40	68					6.5261e-18	7.19712e-18	1	1	0
AQPEP	0	broad.mit.edu	37	5	115327976	115327976	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:115327976C>T	ENST00000357872.4	+	5	1384		c.e5+2		AQPEP_ENST00000395528.2_Splice_Site	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN							proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										GGACACCAGGCATGTGGTAAA	0.383000													42	66					0	0	1	0	0
FBXL8	55336	broad.mit.edu	37	16	67195834	67195834	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67195834A>G	ENST00000258200.3	+	2	323	c.146A>G	c.(145-147)aAa>aGa	p.K49R	FBXL8_ENST00000518148.1_Missense_Mutation_p.K49R|FBXL8_ENST00000519917.1_Missense_Mutation_p.K49R|FBXL8_ENST00000521920.1_Missense_Mutation_p.K49R			Q96CD0	FBXL8_HUMAN	F-box and leucine-rich repeat protein 8	49							protein binding			endometrium(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0144)|Epithelial(162;0.0338)|all cancers(182;0.185)		CACGACACAAAAATCAGGTGA	0.637000													3	6					0	0	1	0	0
SCYL1	57410	broad.mit.edu	37	11	65303494	65303494	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65303494C>T	ENST00000524944.1	+	11	1490	c.1457C>T	c.(1456-1458)gCg>gTg	p.A486V	SCYL1_ENST00000270176.5_Missense_Mutation_p.A486V|SCYL1_ENST00000533862.1_Missense_Mutation_p.A486V|SCYL1_ENST00000279270.6_Missense_Mutation_p.A486V|SCYL1_ENST00000527630.1_Missense_Mutation_p.A486V|SCYL1_ENST00000420247.2_Missense_Mutation_p.A486V|SCYL1_ENST00000527009.1_Missense_Mutation_p.A343V|SCYL1_ENST00000525364.1_Missense_Mutation_p.A486V			Q96KG9	NTKL_HUMAN	SCY1-like 1 (S. cerevisiae)	486					regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			ovary(1)|skin(1)	2						TCCCGGGTTGCGGGTGTCCTG	0.597000													11	43					0	0	1	0	0
MAN2C1	4123	broad.mit.edu	37	15	75648457	75648457	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75648457G>A	ENST00000565683.1	-	25	3052	c.3041C>T	c.(3040-3042)gCc>gTc	p.A1014V	MAN2C1_ENST00000563622.1_Missense_Mutation_p.A898V|MAN2C1_ENST00000569482.1_Missense_Mutation_p.A974V|MAN2C1_ENST00000267978.5_Missense_Mutation_p.A997V	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	997					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						TCACAGGATGGCCTCCTGAAC	0.672000													11	6					0	0	1	0	0
GAS7	8522	broad.mit.edu	37	17	9830018	9830018	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:9830018G>A	ENST00000396115.1	-	10	1084	c.774C>T	c.(772-774)tgC>tgT	p.C258C	GAS7_ENST00000542249.1_Silent_p.C263C|GAS7_ENST00000437099.2_Silent_p.C254C|GAS7_ENST00000580865.1_Silent_p.C178C|GAS7_ENST00000579158.1_Silent_p.C270C|GAS7_ENST00000585266.1_Silent_p.C254C|GAS7_ENST00000432992.2_Silent_p.C318C|GAS7_ENST00000323816.4_Silent_p.C254C|GAS7_ENST00000583882.1_Intron|GAS7_ENST00000540214.1_Intron	NM_201432.1	NP_958836.1	O60861	GAS7_HUMAN	growth arrest-specific 7	318	FCH.				cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity	p.C178*(1)|p.C318*(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(7)|lung(18)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	39						TGTGGTGGTCGCACTTCTTCA	0.592000			T	MLL	AML*								18	22					0	0	1	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291203	141291203	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:141291203G>A	ENST00000247452.3	-	3	918	c.571C>T	c.(571-573)Ctt>Ttt	p.L191F		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	191	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					CCAAAAAGAAGCTCCATGAAC	0.488000										HNSCC(46;0.14)			30	35					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538169	4538169	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4538169G>A	ENST00000306390.6	-	2	1287	c.827C>T	c.(826-828)cCc>cTc	p.P276L	CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	276						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGCCCCTCGGGCACGCTGGC	0.642000													30	42					0	0	1	0	0
ASPRV1	151516	broad.mit.edu	37	2	70187991	70187991	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:70187991G>A	ENST00000320256.4	-	1	1406	c.830C>T	c.(829-831)gCg>gTg	p.A277V		NM_152792.2	NP_690005.2	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1	277	Peptidase A2.				protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)	14						CTCGGCACTCGCATTGGCCAC	0.537000													22	41					0	0	1	0	0
ZNF30	90075	broad.mit.edu	37	19	35434553	35434553	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35434553G>A	ENST00000439785.1	+	5	1130	c.686G>A	c.(685-687)gGg>gAg	p.G229E	ZNF30_ENST00000601142.1_Missense_Mutation_p.G228E|ZNF30_ENST00000426813.2_Missense_Mutation_p.G147E|ZNF30_ENST00000601957.1_3'UTR|ZNF30_ENST00000303586.7_Missense_Mutation_p.G229E	NM_001099438.1	NP_001092908.1	P17039	ZNF30_HUMAN	zinc finger protein 30	228					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)	16	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		ATTCATACTGGGAAGAAACCA	0.428000													5	19					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8784384	8784384	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:8784384C>T	ENST00000359865.3	+	6	1416	c.1274C>T	c.(1273-1275)aCg>aTg	p.T425M	SOGA2_ENST00000400050.3_Missense_Mutation_p.T425M|SOGA2_ENST00000306329.11_Missense_Mutation_p.T785M|SOGA2_ENST00000306285.7_5'UTR|SOGA2_ENST00000517570.1_Missense_Mutation_p.T425M	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	776																	TTTGAGAAGACGTCGGGCTTC	0.637000													19	28					0	0	1	0	0
LUZP1	7798	broad.mit.edu	37	1	23417973	23417973	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:23417973G>A	ENST00000302291.4	-	4	3583	c.2782C>T	c.(2782-2784)Cga>Tga	p.R928*	LUZP1_ENST00000374623.3_Nonsense_Mutation_p.R928*|LUZP1_ENST00000418342.1_Nonsense_Mutation_p.R928*|LUZP1_ENST00000314174.5_Nonsense_Mutation_p.R928*			Q86V48	LUZP1_HUMAN	leucine zipper protein 1	928						nucleus		p.R928*(1)		NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(2)	31		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TTCAAGTCTCGCCTACTCTTC	0.493000													58	93					0	0	1	0	0
HSPA2	3306	broad.mit.edu	37	14	65008446	65008446	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:65008446C>T	ENST00000247207.6	+	1	1261	c.879C>T	c.(877-879)ggC>ggT	p.G293G	HSPA2_ENST00000394709.1_Silent_p.G293G	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	293					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		TCTACGAGGGCGTGGACTTCT	0.687000													7	9					0	0	1	0	0
MFSD6	54842	broad.mit.edu	37	2	191302025	191302025	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:191302025C>T	ENST00000392328.1	+	3	1594	c.1270C>T	c.(1270-1272)Cca>Tca	p.P424S	MFSD6_ENST00000281416.7_Missense_Mutation_p.P424S	NM_017694.3	NP_060164.3	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing 6	424					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						TGAGGAGACACCAACCACCAC	0.498000													23	26					0	0	1	0	0
ZNF547	284306	broad.mit.edu	37	19	57883175	57883175	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:57883175C>T	ENST00000282282.3	+	3	200	c.50C>T	c.(49-51)gCc>gTc	p.A17V	AC003002.4_ENST00000597658.1_Missense_Mutation_p.A17V	NM_173631.2	NP_775902.2	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAAGACGTGGCCATATATTTC	0.428000													73	112					0	0	1	0	0
SEPT4	5414	broad.mit.edu	37	17	56602475	56602475	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56602475G>A	ENST00000426861.1	-	5	655	c.569C>T	c.(568-570)aCa>aTa	p.T190I	SEPT4_ENST00000317268.3_Missense_Mutation_p.T209I|SEPT4_ENST00000583114.1_Missense_Mutation_p.T62I|SEPT4_ENST00000580809.1_Missense_Mutation_p.T91I|RP11-112H10.4_ENST00000580589.1_RNA|SEPT4_ENST00000457347.2_Missense_Mutation_p.T224I|SEPT4_ENST00000579371.1_Missense_Mutation_p.T110I|SEPT4_ENST00000317256.6_Missense_Mutation_p.T190I|SEPT4_ENST00000393086.1_Missense_Mutation_p.T190I|SEPT4_ENST00000412945.3_Missense_Mutation_p.T201I|SEPT4_ENST00000580844.1_Missense_Mutation_p.T110I	NM_080415.2	NP_536340.1	O43236	SEPT4_HUMAN	septin 4	209					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	18	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AAAACCTGGTGTGTCCACAAT	0.522000													4	144					0	0	1	0	0
GRPR	2925	broad.mit.edu	37	X	16170625	16170625	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:16170625C>T	ENST00000380289.2	+	3	1410	c.1012C>T	c.(1012-1014)Ctc>Ttc	p.L338F		NM_005314.2	NP_005305.1	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	338					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					CACTCAGCTGCTCTGTTGCCA	0.572000													40	12					0	0	1	0	0
RPL7A	6130	broad.mit.edu	37	9	136216453	136216453	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136216453C>T	ENST00000323345.6	+	3	202	c.172C>T	c.(172-174)Ccc>Tcc	p.P58S	RPL7A_ENST00000463740.1_3'UTR|RPL7A_ENST00000315731.4_Missense_Mutation_p.A2V	NM_000972.2	NP_000963.1	P62424	RL7A_HUMAN	ribosomal protein L7a	58					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|membrane fraction|polysomal ribosome	RNA binding|structural constituent of ribosome			cervix(1)|endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(145;4.93e-07)|Epithelial(140;4.09e-06)|all cancers(34;3.78e-05)		TGTGAAATGGCCCCGCTATAT	0.537000													12	51					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12389963	12389963	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12389963C>T	ENST00000358136.3	+	37	8405	c.8275C>T	c.(8275-8277)Cgt>Tgt	p.R2759C	VPS13D_ENST00000356315.4_Missense_Mutation_p.R2759C	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2759					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTATTATAACCGTGCTCTTTC	0.368000													15	41					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1042344	1042344	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1042344T>C	ENST00000263094.6	+	6	677	c.446T>C	c.(445-447)cTg>cCg	p.L149P	ABCA7_ENST00000433129.1_Missense_Mutation_p.L149P	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	149					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGTCTCCACTGGAACCACCC	0.677000													9	50					0	0	1	0	0
ZNF548	147694	broad.mit.edu	37	19	57910579	57910579	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:57910579G>A	ENST00000366197.5	+	3	1174	c.924G>A	c.(922-924)ccG>ccA	p.P308P	AC003002.6_ENST00000600421.1_Intron|AC004076.7_ENST00000597410.1_Intron|AC003002.6_ENST00000596400.1_Intron|ZNF548_ENST00000336128.7_Silent_p.P320P	NM_152909.3	NP_690873.2	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	308					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAGAAAGGCCGTATGAGTGCA	0.443000													22	37					0	0	1	0	0
HAT1	8520	broad.mit.edu	37	2	172822331	172822331	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:172822331T>C	ENST00000264108.4	+	6	549	c.513T>C	c.(511-513)ttT>ttC	p.F171F	HAT1_ENST00000392584.1_Silent_p.F86F|SLC25A12_ENST00000472748.1_Intron	NM_003642.3	NP_003633.1	O14929	HAT1_HUMAN	histone acetyltransferase 1	171					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			breast(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|prostate(1)	19			OV - Ovarian serous cystadenocarcinoma(117;0.216)			GTAGAGGCTTTCGAGAATATC	0.403000													21	173					0	0	1	0	0
DOHH	83475	broad.mit.edu	37	19	3494035	3494035	+	Silent	SNP	G	G	A	rs11551227		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3494035G>A	ENST00000427575.1	-	3	793	c.342C>T	c.(340-342)ccC>ccT	p.P114P	DOHH_ENST00000250937.3_Silent_p.P114P	NM_001145165.1	NP_001138637.1	Q9BU89	DOHH_HUMAN	deoxyhypusine hydroxylase/monooxygenase	114					peptidyl-lysine modification to hypusine|post-translational protein modification	cytosol	deoxyhypusine monooxygenase activity|metal ion binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCGATGACGGGGTCCGAGG	0.657000													4	7					0	0	1	0	0
CNR1	0	broad.mit.edu	37	6	88853613	88853613	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:88853613T>C	ENST00000537554.1	-	2	4943	c.1381A>G	c.(1381-1383)Atg>Gtg	p.M461V	CNR1_ENST00000468898.1_Missense_Mutation_p.M428V|CNR1_ENST00000428600.2_Missense_Mutation_p.M461V|CNR1_ENST00000549890.1_Missense_Mutation_p.M461V|CNR1_ENST00000369499.2_Missense_Mutation_p.M461V|CNR1_ENST00000369501.2_Missense_Mutation_p.M461V|CNR1_ENST00000549716.1_Missense_Mutation_p.M400V|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000535130.1_Missense_Mutation_p.M461V	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	461					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GACACAGACATGGTTACCTTG	0.507000													58	86					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120613962	120613962	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:120613962G>A	ENST00000300648.6	-	10	909	c.897C>T	c.(895-897)atC>atT	p.I299I		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	299					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTCCTTTCACGATGTCCATGG	0.512000													19	32					0	0	1	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28214308	28214308	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:28214308T>C	ENST00000284984.2	-	3	1533	c.1077_splice	c.e3-1	p.D360_splice		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	360	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		CCCACACAAGTCCTACAAAAA	0.448000													21	7					0	0	1	0	0
C10orf11	83938	broad.mit.edu	37	10	77542742	77542742	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:77542742G>T	ENST00000372499.1	+	1	224	c.9G>T	c.(7-9)aaG>aaT	p.K3N	C10orf11_ENST00000593699.1_Intron	NM_032024.3	NP_114413.1	Q9H2I8	CJ011_HUMAN	chromosome 10 open reading frame 11	3										endometrium(1)|large_intestine(4)|lung(4)|stomach(1)	10	Prostate(51;0.0095)|all_epithelial(25;0.0221)					GAATGGAAAAGTATTTGTCAC	0.418000													23	52					6.44725e-10	6.8705e-10	1	1	0
GRIN2C	2905	broad.mit.edu	37	17	72843504	72843504	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72843504G>A	ENST00000293190.5	-	9	2090	c.1944C>T	c.(1942-1944)gcC>gcT	p.A648A	GRIN2C_ENST00000347612.4_Silent_p.A648A	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	648					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	TCATGAAGGCGGCCAGGTTGG	0.607000													36	61					0	0	1	0	0
CMKLR1	1240	broad.mit.edu	37	12	108685777	108685777	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:108685777C>A	ENST00000397688.2	-	3	1326	c.957G>T	c.(955-957)caG>caT	p.Q319H	CMKLR1_ENST00000552995.1_Missense_Mutation_p.Q319H|CMKLR1_ENST00000550402.1_Missense_Mutation_p.Q321H|CMKLR1_ENST00000412676.1_Missense_Mutation_p.Q321H|CMKLR1_ENST00000312143.7_Missense_Mutation_p.Q321H	NM_004072.2	NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	321					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						TCTTGAAGTCCTGACCCATGA	0.532000													27	31					3.65163e-15	3.99483e-15	1	1	0
TAF3	83860	broad.mit.edu	37	10	8006411	8006411	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:8006411G>A	ENST00000344293.5	+	3	1144	c.938G>A	c.(937-939)gGa>gAa	p.G313E		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	313					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						AAATCACCTGGACGTTccaag	0.502000													10	13					0	0	1	0	0
OR6Q1	219952	broad.mit.edu	37	11	57798998	57798998	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57798998T>C	ENST00000302622.3	+	1	597	c.574T>C	c.(574-576)Tcg>Ccg	p.S192P	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				GCTAGCCTTGTCGTGCTCAGA	0.493000													8	80					0	0	1	0	0
LYPD5	284348	broad.mit.edu	37	19	44301832	44301832	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44301832T>C	ENST00000377950.3	-	5	747	c.667A>G	c.(667-669)Acc>Gcc	p.T223A	LYPD5_ENST00000414615.2_Missense_Mutation_p.T180A|LYPD5_ENST00000594013.1_Missense_Mutation_p.T180A	NM_001031749.2	NP_001026919.2	Q6UWN5	LYPD5_HUMAN	LY6/PLAUR domain containing 5	223						anchored to membrane|plasma membrane				breast(3)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|urinary_tract(1)	8		Prostate(69;0.0352)				GAAGCACTGGTGAAGGGCTGG	0.657000													10	19					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102851496	102851496	+	Silent	SNP	C	C	T	rs35960329	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:102851496C>T	ENST00000264257.2	+	11	1563	c.1437C>T	c.(1435-1437)gaC>gaT	p.D479D	IL1RL2_ENST00000481806.1_3'UTR|IL1RL2_ENST00000539491.1_Silent_p.D479D|IL1RL2_ENST00000441515.2_Silent_p.D361D	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	479	TIR.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity	p.D479D(1)|p.D361D(1)		breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						TGATCCAGGACGGGATGAAGG	0.502000													20	22					0	0	1	0	0
IFI16	3428	broad.mit.edu	37	1	158984686	158984686	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158984686A>G	ENST00000295809.7	+	2	471	c.216A>G	c.(214-216)atA>atG	p.I72M	IFI16_ENST00000448393.2_Missense_Mutation_p.I72M|IFI16_ENST00000430894.2_Missense_Mutation_p.I76M|IFI16_ENST00000368132.3_Missense_Mutation_p.I72M|IFI16_ENST00000368131.4_Missense_Mutation_p.I72M|IFI16_ENST00000340979.6_Missense_Mutation_p.I72M|IFI16_ENST00000359709.3_Missense_Mutation_p.I72M			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	72	DAPIN.|Lys-rich.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					TCGAAGATATACCAACGCTTG	0.413000													27	48					0	0	1	0	0
EIF4A1	1973	broad.mit.edu	37	17	7481551	7481551	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7481551C>T	ENST00000293831.8	+	10	1081	c.1065C>T	c.(1063-1065)aaC>aaT	p.N355N	SENP3-EIF4A1_ENST00000579777.1_RNA|EIF4A1_ENST00000582746.1_Intron|EIF4A1_ENST00000577269.1_Silent_p.L335L	NM_001416.3	NP_001407.1	P60842	IF4A1_HUMAN	eukaryotic translation initiation factor 4A1	355	Helicase C-terminal.				nuclear-transcribed mRNA poly(A) tail shortening	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA cap binding|translation initiation factor activity			NS(1)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	22						ACAGGGAAAACTATATCCACA	0.498000													11	35					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52002816	52002816	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:52002816G>T	ENST00000291707.3	-	3	1018	c.963C>A	c.(961-963)atC>atA	p.I321I	SIGLEC12_ENST00000598614.1_Silent_p.I203I	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	321	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AGGAGCGAGTGATAGTGGGGT	0.662000													11	24					1.58986e-06	1.65464e-06	1	1	0
ZNF763	284390	broad.mit.edu	37	19	12089533	12089533	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12089533T>C	ENST00000343949.5	+	4	958	c.803T>C	c.(802-804)tTc>tCc	p.F268S	ZNF763_ENST00000545530.1_Missense_Mutation_p.F143S|ZNF763_ENST00000358987.3_Missense_Mutation_p.F265S|ZNF763_ENST00000590798.1_Missense_Mutation_p.F285S|ZNF763_ENST00000538752.1_Missense_Mutation_p.F285S	NM_001012753.1	NP_001012771.1			zinc finger protein 763											central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)	15						GGGAAAGCATTCCATAGTTCC	0.398000													30	45					0	0	1	0	0
USP14	9097	broad.mit.edu	37	18	163395	163395	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:163395C>T	ENST00000261601.6	+	2	195	c.104C>T	c.(103-105)gCg>gTg	p.A35V	USP14_ENST00000582707.1_Missense_Mutation_p.A35V|USP14_ENST00000383589.2_Missense_Mutation_p.A35V|USP14_ENST00000400266.3_Missense_Mutation_p.A35V	NM_005151.3	NP_005142.1	P54578	UBP14_HUMAN	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	35	Ubiquitin-like.				regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(2)	11		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				CAGCTGTTTGCGTTGACTGGA	0.383000													21	17					0	0	1	0	0
RFFL	117584	broad.mit.edu	37	17	33339066	33339066	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:33339066G>A	ENST00000315249.7	-	7	1235	c.1013C>T	c.(1012-1014)aCc>aTc	p.T338I	RFFL_ENST00000413582.2_Missense_Mutation_p.T330I|RFFL_ENST00000415395.2_Missense_Mutation_p.T338I|RFFL_ENST00000394597.2_Missense_Mutation_p.T338I|RFFL_ENST00000268850.7_Missense_Mutation_p.T302I|RAD51L3-RFFL_ENST00000593039.1_Missense_Mutation_p.T247I|RFFL_ENST00000584655.1_Missense_Mutation_p.T302I|RFFL_ENST00000378516.2_Missense_Mutation_p.T330I|RFFL_ENST00000447669.2_Missense_Mutation_p.T338I			Q8WZ73	RFFL_HUMAN	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	338					apoptosis	membrane	ligase activity|zinc ion binding			kidney(1)|large_intestine(2)|lung(3)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		GCCACACTTGGTACAGGTTAC	0.517000													16	19					0	0	1	0	0
LGALS14	56891	broad.mit.edu	37	19	40199920	40199920	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:40199920T>C	ENST00000392052.3	+	4	610	c.387T>C	c.(385-387)gaT>gaC	p.D129D	LGALS14_ENST00000360675.3_Silent_p.D158D	NM_020129.2	NP_064514.1	Q8TCE9	PPL13_HUMAN	lectin, galactoside-binding, soluble, 14	129	Galectin.					nucleus	sugar binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|skin(2)|stomach(2)	14	all_cancers(60;4.39e-06)|all_lung(34;6.76e-08)|Lung NSC(34;7.98e-08)|Ovarian(47;0.06)	Myeloproliferative disorder(2;0.0741)	Epithelial(26;1.08e-24)|OV - Ovarian serous cystadenocarcinoma(5;1.92e-24)|all cancers(26;4.12e-22)			TCTTCAGAGATATCTCCCTGA	0.473000													25	34					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73746878	73746878	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73746878G>A	ENST00000200181.3	+	29	3779	c.3592G>A	c.(3592-3594)Gcc>Acc	p.A1198T	ITGB4_ENST00000579662.1_Missense_Mutation_p.A1198T|ITGB4_ENST00000450894.3_Missense_Mutation_p.A1198T|ITGB4_ENST00000339591.3_Missense_Mutation_p.A1198T|ITGB4_ENST00000449880.2_Missense_Mutation_p.A1198T	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1198	Fibronectin type-III 1.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity	p.A1198T(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GAAGGTGTGCGCCTACGGGGC	0.627000													23	50					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5011027	5011027	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5011027G>A	ENST00000380390.1	+	3	465	c.249G>A	c.(247-249)ggG>ggA	p.G83G	MMP26_ENST00000300762.1_Silent_p.G83G|MMP26_ENST00000477339.1_3'UTR			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	83					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCCACTGTGGGGTGCCTGATG	0.517000													10	27					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2892105	2892105	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:2892105G>T	ENST00000254528.3	+	4	2139	c.1980G>T	c.(1978-1980)caG>caT	p.Q660H		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	660					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		CGTCCCCCCAGCACCCCGTGG	0.572000													14	19					4.36969e-10	4.65946e-10	1	1	0
ATP10A	57194	broad.mit.edu	37	15	25959378	25959378	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:25959378C>A	ENST00000356865.6	-	10	1898	c.1787G>T	c.(1786-1788)aGg>aTg	p.R596M		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	596					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CAGCTCAAACCTCACCCTCAC	0.602000													15	25					1.02788e-11	1.10723e-11	1	1	0
LAMA5	3911	broad.mit.edu	37	20	60904282	60904282	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:60904282C>T	ENST00000252999.3	-	33	4213	c.4147G>A	c.(4147-4149)Gtc>Atc	p.V1383I		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1383	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAGCTGTAGACGTTCTCAGGG	0.637000													25	35					0	0	1	0	0
PTPN7	5778	broad.mit.edu	37	1	202128422	202128422	+	Nonsense_Mutation	SNP	G	G	A	rs149516769		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:202128422G>A	ENST00000309017.3	-	2	1197	c.424C>T	c.(424-426)Cga>Tga	p.R142*	PTPN7_ENST00000367279.4_Nonsense_Mutation_p.R76*|PTPN7_ENST00000544762.1_5'UTR|PTPN7_ENST00000308986.5_Nonsense_Mutation_p.R37*|PTPN7_ENST00000543735.1_5'UTR	NM_001199797.1|NM_002832.3	NP_001186726.1|NP_002823.3	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type 7	37	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity	p.R76*(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|soft_tissue(1)|urinary_tract(1)	13						TCCTGCAGTCGCACATGCTTC	0.632000													13	15					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105180579	105180579	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105180579C>T	ENST00000392634.4	+	21	3192	c.3080C>T	c.(3079-3081)aCg>aTg	p.T1027M	INF2_ENST00000330634.7_Missense_Mutation_p.T1027M	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	1027					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		GTGGGCAGCACGCGCTGTCCC	0.692000													4	5					0	0	1	0	0
KDELR1	10945	broad.mit.edu	37	19	48887660	48887660	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:48887660G>A	ENST00000597017.1	-	3	670	c.245C>T	c.(244-246)gCg>gTg	p.A82V	KDELR1_ENST00000330720.2_Missense_Mutation_p.A144V			P24390	ERD21_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	144					intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane|membrane fraction	KDEL sequence binding|protein binding|receptor activity			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|pancreas(1)|urinary_tract(1)	11		all_epithelial(76;2.48e-06)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Prostate(7;0.122)|Breast(70;0.203)		all cancers(93;0.000114)|OV - Ovarian serous cystadenocarcinoma(262;0.000136)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.0145)		GATGGTCTCCGCCTCGCCGGT	0.572000													10	9					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13824306	13824306	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:13824306A>G	ENST00000265104.4	-	39	6684		c.e39+1			NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGTGAGTCTTACCAGTTTAGA	0.398000									Kartagener syndrome				10	34					0	0	1	0	0
OSBPL3	26031	broad.mit.edu	37	7	24849506	24849506	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:24849506G>A	ENST00000313367.2	-	20	2688	c.2237C>T	c.(2236-2238)gCg>gTg	p.A746V	OSBPL3_ENST00000353930.1_Missense_Mutation_p.A710V|OSBPL3_ENST00000352860.1_Missense_Mutation_p.A715V|OSBPL3_ENST00000396429.1_Missense_Mutation_p.A710V|OSBPL3_ENST00000396431.1_Missense_Mutation_p.A715V|OSBPL3_ENST00000487020.1_5'UTR|OSBPL3_ENST00000431825.2_Missense_Mutation_p.A679V|OSBPL3_ENST00000409069.1_Missense_Mutation_p.A679V	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	746					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						CCGATGAACCGCTTTTCCACT	0.488000													79	101					0	0	1	0	0
CXXC5	51523	broad.mit.edu	37	5	139060174	139060174	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:139060174C>T	ENST00000302517.3	+	2	780	c.66C>T	c.(64-66)agC>agT	p.S22S	CXXC5_ENST00000511048.1_Silent_p.S22S	NM_016463.7	NP_057547.5	Q7LFL8	CXXC5_HUMAN	CXXC finger protein 5	22					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ccaatggcagcggtggcagtg	0.682000													3	4					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37167160	37167160	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:37167160G>A	ENST00000274258.7	-	35	7616	c.4029C>T	c.(4027-4029)gaC>gaT	p.D1343D	C5orf42_ENST00000508244.1_Silent_p.D2463D|C5orf42_ENST00000425232.2_Silent_p.D2463D			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2463										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TTTTTTTACTGTCCTTTCCTT	0.318000													11	36					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94050332	94050332	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:94050332T>C	ENST00000297268.6	+	38	2778	c.2307T>C	c.(2305-2307)ggT>ggC	p.G769G		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	769			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GTCCAAATGGTCCCCCCGGTC	0.453000										HNSCC(75;0.22)			14	35					0	0	1	0	0
PDE8A	5151	broad.mit.edu	37	15	85652350	85652350	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:85652350G>A	ENST00000310298.4	+	13	1355	c.1103G>A	c.(1102-1104)cGt>cAt	p.R368H	PDE8A_ENST00000339708.5_Missense_Mutation_p.R322H|PDE8A_ENST00000557957.1_Missense_Mutation_p.R296H|PDE8A_ENST00000394553.1_Missense_Mutation_p.R368H|PDE8A_ENST00000557819.2_3'UTR			O60658	PDE8A_HUMAN	phosphodiesterase 8A	368					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	25	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			GTTGCCTCCCGTGCAACTGAA	0.448000													4	24					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936755	15936755	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:15936755C>T	ENST00000504595.1	+	4	1417	c.936C>T	c.(934-936)acC>acT	p.T312T	FBXL7_ENST00000329673.7_Silent_p.T300T|FBXL7_ENST00000510662.1_Silent_p.T265T	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	312					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						TCCGCCTGACCGACGAAGGCC	0.662000													4	9					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123060443	123060443	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:123060443A>G	ENST00000333479.7	+	29	2760	c.2583A>G	c.(2581-2583)atA>atG	p.I861M	KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	861					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		ACAAGGAAATAATGGTAAGTA	0.338000													8	12					0	0	1	0	0
RPS5	6193	broad.mit.edu	37	19	58904796	58904796	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58904796G>A	ENST00000596046.1	+	3	1238	c.389G>A	c.(388-390)cGc>cAc	p.R130H	RPS5_ENST00000598098.1_Missense_Mutation_p.R60H|RPS5_ENST00000598495.1_Missense_Mutation_p.R151H|RPS5_ENST00000601521.1_Missense_Mutation_p.R130H|RPS5_ENST00000196551.3_Missense_Mutation_p.R130H			P46782	RS5_HUMAN	ribosomal protein S5	130					endocrine pancreas development|regulation of translational fidelity|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|structural constituent of ribosome			cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4		all_cancers(17;1.71e-22)|all_epithelial(17;1.69e-16)|Lung NSC(17;2.25e-06)|all_lung(17;9.97e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Breast(46;0.0194)|Ovarian(87;0.0443)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.171)|GBM - Glioblastoma multiforme(193;0.0323)|Lung(386;0.0543)|LUSC - Lung squamous cell carcinoma(496;0.176)		CGCATTGGGCGCGCCGGGACT	0.622000													13	37					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87080982	87080982	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:87080982G>A	ENST00000265723.4	-	7	776	c.665C>T	c.(664-666)gCc>gTc	p.A222V	ABCB4_ENST00000359206.3_Missense_Mutation_p.A222V|ABCB4_ENST00000358400.3_Missense_Mutation_p.A222V|ABCB4_ENST00000453593.1_Missense_Mutation_p.A222V|ABCB4_ENST00000545634.1_Missense_Mutation_p.A222V	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	222	ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AGGGCTGATGGCCATTATCAC	0.458000													10	43					0	0	1	0	0
SDHAP1	0	broad.mit.edu	37	3	195701286	195701286	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195701286C>T	ENST00000427841.1	-	0	1538					NR_003264.2																						CACGACTCTGCGATGCTCAGG	0.537000													18	46					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52573657	52573657	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:52573657G>T	ENST00000395489.2	-	12	1682	c.1286C>A	c.(1285-1287)cCt>cAt	p.P429H	A1CF_ENST00000374001.1_Missense_Mutation_p.P428H|A1CF_ENST00000373995.3_Missense_Mutation_p.P436H|A1CF_ENST00000373993.1_Missense_Mutation_p.P436H|ASAH2B_ENST00000483649.1_Intron|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000395495.1_Missense_Mutation_p.P381H|A1CF_ENST00000373997.3_Missense_Mutation_p.P428H|A1CF_ENST00000282641.2_Missense_Mutation_p.P436H	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	436					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						TAATGTGACAGGATTCATTGG	0.433000													18	109					3.8784e-16	4.25337e-16	1	1	0
DIDO1	11083	broad.mit.edu	37	20	61538606	61538606	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:61538606C>T	ENST00000266070.4	-	5	1592	c.1267G>A	c.(1267-1269)Gca>Aca	p.A423T	DIDO1_ENST00000395343.1_Missense_Mutation_p.A423T|DIDO1_ENST00000370368.1_Missense_Mutation_p.A423T|DIDO1_ENST00000395340.1_Missense_Mutation_p.A423T|DIDO1_ENST00000395335.2_Missense_Mutation_p.A423T|DIDO1_ENST00000370366.1_Missense_Mutation_p.A423T|DIDO1_ENST00000266071.5_Missense_Mutation_p.A423T|DIDO1_ENST00000370371.4_Missense_Mutation_p.A423T|DIDO1_ENST00000354665.4_Missense_Mutation_p.A423T	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	423					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding	p.A423T(1)		NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					ATTGTCGCTGCGGCGTGTTTG	0.522000													54	84					0	0	1	0	0
OR10K2	391107	broad.mit.edu	37	1	158390557	158390557	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158390557G>T	ENST00000314902.2	-	1	99	c.100C>A	c.(100-102)Ctc>Atc	p.L34I		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					AACAGGTAGAGGAGCAGGAAG	0.532000													13	40					2.27111e-07	2.37911e-07	1	1	0
SCYL1	57410	broad.mit.edu	37	11	65298235	65298235	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65298235G>A	ENST00000524944.1	+	7	1018	c.985G>A	c.(985-987)Gtt>Att	p.V329I	SCYL1_ENST00000270176.5_Missense_Mutation_p.V329I|SCYL1_ENST00000533862.1_Missense_Mutation_p.V329I|SCYL1_ENST00000279270.6_Missense_Mutation_p.V329I|SCYL1_ENST00000527630.1_Missense_Mutation_p.V329I|SCYL1_ENST00000420247.2_Missense_Mutation_p.V329I|SCYL1_ENST00000527009.1_Missense_Mutation_p.V186I|SCYL1_ENST00000525364.1_Missense_Mutation_p.V329I			Q96KG9	NTKL_HUMAN	SCY1-like 1 (S. cerevisiae)	329					regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity	p.V329I(1)		ovary(1)|skin(1)	2						TGCTGGGGCCGTTGTCCTCAC	0.622000													26	42					0	0	1	0	0
OTUD5	55593	broad.mit.edu	37	X	48792092	48792092	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:48792092T>C	ENST00000156084.4	-	4	862	c.802A>G	c.(802-804)Acc>Gcc	p.T268A	OTUD5_ENST00000484499.1_5'UTR|OTUD5_ENST00000376488.3_Missense_Mutation_p.T268A|OTUD5_ENST00000396743.3_Missense_Mutation_p.T268A|OTUD5_ENST00000428668.2_Missense_Mutation_p.T51A	NM_017602.3	NP_060072.1	Q96G74	OTUD5_HUMAN	OTU domain containing 5	268	OTU.				negative regulation of type I interferon production		cysteine-type peptidase activity			endometrium(2)|large_intestine(3)|lung(6)|pancreas(2)	13						TTAATGTAGGTGGTAAAGTCC	0.468000													60	18					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3134559	3134559	+	Missense_Mutation	SNP	C	C	T	rs140979048	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:3134559C>T	ENST00000355072.5	+	18	2559	c.2414C>T	c.(2413-2415)gCg>gTg	p.A805V		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	805					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TTTTCTTTGGCGGATTGCATT	0.383000													46	82					0	0	1	0	0
CLCN6	1185	broad.mit.edu	37	1	11898394	11898394	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11898394C>T	ENST00000346436.6	+	21	2350	c.2298C>T	c.(2296-2298)agC>agT	p.S766S	CLCN6_ENST00000376487.3_Silent_p.S744S|CLCN6_ENST00000376496.3_Silent_p.S766S|CLCN6_ENST00000312413.6_3'UTR	NM_001286.3	NP_001277.1	P51797	CLCN6_HUMAN	chloride channel, voltage-sensitive 6	766					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(4)	36	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		AATTGCAGAGCGCCAGCCAGC	0.642000											OREG0013104	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	17					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124402700	124402700	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:124402700G>A	ENST00000338354.3	+	53	7134	c.7028G>A	c.(7027-7029)cGg>cAg	p.R2343Q	DMBT1_ENST00000344338.3_Missense_Mutation_p.R2333Q|DMBT1_ENST00000368909.3_Missense_Mutation_p.R2343Q|DMBT1_ENST00000368955.3_Missense_Mutation_p.R2333Q|DMBT1_ENST00000359586.6_Missense_Mutation_p.R1063Q|DMBT1_ENST00000330163.4_Missense_Mutation_p.R1715Q|DMBT1_ENST00000368956.2_Missense_Mutation_p.R1715Q			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2343	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GCCCGCTTCCGGTTCAGGGCC	0.582000													10	101					0	0	1	0	0
RFWD2	64326	broad.mit.edu	37	1	176054920	176054920	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:176054920C>T	ENST00000367669.3	-	10	1647	c.1133G>A	c.(1132-1134)cGt>cAt	p.R378H	RFWD2_ENST00000308769.8_Missense_Mutation_p.R354H	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	378					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						ACCTGAGATACGAGACATCCT	0.358000													56	131					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505287	195505287	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195505287C>T	ENST00000463781.3	-	3	13289	c.12830G>A	c.(12829-12831)cGc>cAc	p.R4277H	MUC4_ENST00000475231.1_Missense_Mutation_p.R4277H|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Missense_Mutation_p.R41H	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1034					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTGGCTGTGCGTCTCCCACC	0.557000													21	26					0	0	1	0	0
BDKRB2	0	broad.mit.edu	37	14	96706996	96706996	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:96706996C>T	ENST00000542454.2	+	3	3338	c.250C>T	c.(250-252)Ccc>Tcc	p.P84S	RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000554311.1_Missense_Mutation_p.P111S|BDKRB2_ENST00000306005.3_Missense_Mutation_p.P111S|BDKRB2_ENST00000539359.1_Missense_Mutation_p.P84S			P30411	BKRB2_HUMAN	bradykinin receptor B2	111					arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		CTGCGGGCTGCCCTTCTGGGC	0.597000													39	66					0	0	1	0	0
BAHD1	22893	broad.mit.edu	37	15	40750862	40750862	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40750862C>T	ENST00000561234.1	+	2	458	c.199C>T	c.(199-201)Ccc>Tcc	p.P67S	BAHD1_ENST00000416165.1_Missense_Mutation_p.P67S|BAHD1_ENST00000560846.1_Missense_Mutation_p.P67S			Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	67					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(3)|lung(10)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	28		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		TCCTGAGAAGCCCAAGGCCTG	0.632000													20	29					0	0	1	0	0
DDX56	54606	broad.mit.edu	37	7	44612296	44612296	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44612296C>T	ENST00000258772.5	-	4	537	c.431G>A	c.(430-432)cGc>cAc	p.R144H	DDX56_ENST00000431640.1_Missense_Mutation_p.R144H|DDX56_ENST00000485367.1_5'UTR	NM_001257189.1|NM_019082.3	NP_001244118.1|NP_061955.1	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 56	144	Helicase ATP-binding.				rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(5)|upper_aerodigestive_tract(1)	16						GCTTAATATGCGAGATGGGGT	0.502000													36	26					0	0	1	0	0
SCAI	286205	broad.mit.edu	37	9	127733744	127733744	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:127733744C>T	ENST00000336505.5	-	17	1637	c.1579G>A	c.(1579-1581)Gca>Aca	p.A527T	SCAI_ENST00000373549.4_Missense_Mutation_p.A550T	NM_001144877.2	NP_001138349.1	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion	527					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(5)|stomach(1)|urinary_tract(1)	35						TGGAGAAATGCCTGATCTGCA	0.398000													19	28					0	0	1	0	0
THOP1	7064	broad.mit.edu	37	19	2807564	2807564	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2807564G>A	ENST00000307741.6	+	8	1214	c.1011G>A	c.(1009-1011)atG>atA	p.M337I	THOP1_ENST00000586677.1_Missense_Mutation_p.M216I|THOP1_ENST00000591149.1_3'UTR	NM_003249.3	NP_003240.1	P52888	THOP1_HUMAN	thimet oligopeptidase 1	337					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|lung(8)|ovary(2)|skin(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGGGACATGCGCTACTACA	0.667000													11	13					0	0	1	0	0
SPN	0	broad.mit.edu	37	16	29675489	29675489	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:29675489G>A	ENST00000360121.3	+	2	532	c.440G>A	c.(439-441)aGt>aAt	p.S147N	SPN_ENST00000395389.2_Missense_Mutation_p.S147N|AC009133.19_ENST00000449759.1_Intron	NM_001030288.2|NM_003123.4	NP_001025459.1|NP_003114.1	P16150	LEUK_HUMAN	sialophorin	147					blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|stomach(1)	15						AGTAGGACCAGTGGAGCCCCT	0.542000													25	23					0	0	1	0	0
TXNDC16	57544	broad.mit.edu	37	14	52936757	52936757	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:52936757G>A	ENST00000281741.4	-	16	1987	c.1616C>T	c.(1615-1617)aCa>aTa	p.T539I	TXNDC16_ENST00000554399.1_Intron	NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	539					cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					CTGCTTACCTGTTTTCATGGT	0.299000													26	72					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2160656	2160656	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2160656G>A	ENST00000262304.4	-	15	4720	c.4512C>T	c.(4510-4512)gaC>gaT	p.D1504D	PKD1_ENST00000423118.1_Silent_p.D1504D	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	1504	PKD 10.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GCCACCCACCGTCCCCCAGAT	0.657000													20	20					0	0	1	0	0
CHST8	64377	broad.mit.edu	37	19	34263822	34263822	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:34263822C>T	ENST00000262622.3	+	4	1887	c.1129C>T	c.(1129-1131)Cac>Tac	p.H377Y	CHST8_ENST00000438847.2_Missense_Mutation_p.H377Y|CHST8_ENST00000434302.1_Missense_Mutation_p.H377Y	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	377					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					CAAGGACCGGCACTCGCAGGA	0.617000													8	17					0	0	1	0	0
KDM1A	23028	broad.mit.edu	37	1	23397787	23397787	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:23397787C>T	ENST00000400181.4	+	13	1587	c.1483C>T	c.(1483-1485)Ccc>Tcc	p.P495S	KDM1A_ENST00000542151.1_Missense_Mutation_p.P495S|KDM1A_ENST00000356634.3_Missense_Mutation_p.P471S|RP1-184J9.2_ENST00000427154.1_RNA	NM_001009999.2	NP_001009999.1	O60341	KDM1A_HUMAN	lysine (K)-specific demethylase 1A	471	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(2)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						AGTAAAGCCACCCAGAGATAT	0.378000													36	38					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57110170	57110170	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57110170G>T	ENST00000454682.1	-	3	5425	c.5144C>A	c.(5143-5145)cCt>cAt	p.P1715H	NACA_ENST00000550952.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000552540.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGGGCATATAGGAGGTGAAGT	0.498000			T	BCL6	NHL								84	150					1.06222e-33	1.19224e-33	1	1	0
TRIM25	7706	broad.mit.edu	37	17	54969543	54969543	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:54969543C>T	ENST00000316881.4	-	9	1460	c.1411G>A	c.(1411-1413)Gct>Act	p.A471T	TRIM25_ENST00000537230.1_Missense_Mutation_p.A471T	NM_005082.4	NP_005073.2	Q14258	TRI25_HUMAN	tripartite motif containing 25	471	B30.2/SPRY.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Breast(9;6.15e-08)					TCTGACAGAGCCACTTTGTTG	0.498000													51	79					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43483842	43483842	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:43483842C>T	ENST00000395891.1	+	11	1676	c.1071C>T	c.(1069-1071)acC>acT	p.T357T	HECW1_ENST00000453890.1_Silent_p.T357T	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	357					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CCCTGAGTACCGAGCCTGAGT	0.512000													21	23					0	0	1	0	0
ZNF775	285971	broad.mit.edu	37	7	150093913	150093913	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150093913G>A	ENST00000329630.5	+	3	451	c.344G>A	c.(343-345)aGg>aAg	p.R115K		NM_173680.3	NP_775951.2	Q96BV0	ZN775_HUMAN	zinc finger protein 775	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(7)|skin(1)	11	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCGGGAAGAGGTTCAGCTGG	0.682000													8	4					0	0	1	0	0
PRSS38	339501	broad.mit.edu	37	1	228003511	228003511	+	Missense_Mutation	SNP	G	G	A	rs145063024		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:228003511G>A	ENST00000366757.3	+	1	118	c.94G>A	c.(94-96)Gca>Aca	p.A32T		NM_183062.2	NP_898885.1	A1L453	PRS38_HUMAN	protease, serine, 38	32					proteolysis	extracellular region	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						CCGGGTCGCAGCATTGGTCCA	0.687000													12	6					0	0	1	0	0
KRT20	54474	broad.mit.edu	37	17	39034435	39034435	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39034435A>G	ENST00000167588.3	-	6	1142	c.1101T>C	c.(1099-1101)atT>atC	p.I367I		NM_019010.2	NP_061883.1	P35900	K1C20_HUMAN	keratin 20	367	Coil 2.|Rod.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	14		Breast(137;0.000301)|Ovarian(249;0.15)				GGTAAGTAGCAATTTCCTGTT	0.433000													19	200					0	0	1	0	0
GPR21	2844	broad.mit.edu	37	9	125797009	125797009	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:125797009G>A	ENST00000373642.1	+	1	204	c.164G>A	c.(163-165)tGt>tAt	p.C55Y	RABGAP1_ENST00000373643.5_Intron|RABGAP1_ENST00000493854.1_Intron|RABGAP1_ENST00000373647.4_Intron	NM_005294.1	NP_005285.1	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	55						integral to plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	15						GTATTTCACTGTGCACCTTTG	0.363000													4	92					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15468417	15468417	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:15468417G>A	ENST00000281513.5	-	37	4392	c.4367C>T	c.(4366-4368)gCa>gTa	p.A1456V	NBAS_ENST00000441750.1_Missense_Mutation_p.A1336V	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1456								p.A1456V(1)		NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						GATTTGATATGCACCACCACA	0.378000													50	58					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62294559	62294559	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62294559G>A	ENST00000378024.4	-	5	7604	c.7330C>T	c.(7330-7332)Cct>Tct	p.P2444S	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2444					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGCATATCAGGCATCTTGAAC	0.468000													58	81					0	0	1	0	0
SLC25A11	8402	broad.mit.edu	37	17	4841189	4841189	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4841189G>A	ENST00000225665.7	-	8	1132	c.792C>T	c.(790-792)gaC>gaT	p.D264D	SLC25A11_ENST00000544061.2_Silent_p.D213D	NM_001165417.1|NM_003562.4	NP_001158889.1|NP_003553.2	Q02978	M2OM_HUMAN	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	264					gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	10						TGAACAGCACGTCCTAGACAC	0.632000													17	23					0	0	1	0	0
SSTR5	0	broad.mit.edu	37	16	1129430	1129430	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1129430G>A	ENST00000293897.4	+	1	650	c.562G>A	c.(562-564)Gcc>Acc	p.A188T	SSTR5_ENST00000562758.1_Missense_Mutation_p.A188T|SSTR5_ENST00000397547.2_Missense_Mutation_p.A188T	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	188					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	TACCTGCAACGCCAGCTGGCC	0.687000													3	5					0	0	1	0	0
MAT1A	4143	broad.mit.edu	37	10	82036245	82036245	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:82036245G>A	ENST00000372213.3	-	6	915	c.655C>T	c.(655-657)Cgc>Tgc	p.R219C		NM_000429.2	NP_000420.1	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	219					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity	p.R219C(1)		endometrium(4)|large_intestine(7)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	AGGGCCCTGCGCATCTCCTCC	0.587000													14	73					0	0	1	0	0
WNT7A	7476	broad.mit.edu	37	3	13860467	13860467	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:13860467G>A	ENST00000285018.4	-	4	1328	c.1024C>T	c.(1024-1026)Cgc>Tgc	p.R342C		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	342					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						ATCTCCGTGCGCTCGCTGCAC	0.607000													12	23					0	0	1	0	0
NHP2L1	4809	broad.mit.edu	37	22	42071032	42071032	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:42071032G>A	ENST00000401959.1	-	4	608	c.292C>T	c.(292-294)Cct>Tct	p.P98S	NHP2L1_ENST00000402458.1_Missense_Mutation_p.P102S|NHP2L1_ENST00000355257.3_Missense_Mutation_p.P98S|NHP2L1_ENST00000463675.1_5'UTR|NHP2L1_ENST00000215956.5_Missense_Mutation_p.P98S	NM_005008.3	NP_004999.1	P55769	NH2L1_HUMAN	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)	98					nuclear mRNA splicing, via spliceosome|ribosome biogenesis	box C/D snoRNP complex|nucleoplasm|spliceosomal complex	protein binding|RNA binding			endometrium(1)|kidney(1)|lung(1)|prostate(1)	4						GCGATGACAGGCCTGGAGACC	0.542000													26	35					0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90577857	90577857	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:90577857C>T	ENST00000551025.1	+	0	6285							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		AAGAACAGAGCTCTATGATAC	0.343000													10	19					0	0	1	0	0
REPIN1	29803	broad.mit.edu	37	7	150069895	150069895	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150069895G>A	ENST00000397281.2	+	4	2054	c.1565G>A	c.(1564-1566)cGc>cAc	p.R522H	REPIN1_ENST00000489432.2_Missense_Mutation_p.R579H|REPIN1_ENST00000479668.1_3'UTR|REPIN1_ENST00000444957.1_Missense_Mutation_p.R522H|REPIN1_ENST00000540729.1_Missense_Mutation_p.R522H|REPIN1_ENST00000425389.2_Missense_Mutation_p.R522H	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	522					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			GACTGCGACCGCAGCTTCAGC	0.657000													16	25					0	0	1	0	0
MSANTD4	84437	broad.mit.edu	37	11	105880389	105880389	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:105880389C>T	ENST00000301919.4	-	3	2326	c.911G>A	c.(910-912)cGc>cAc	p.R304H	MSANTD4_ENST00000529805.1_5'UTR	NM_032424.1	NP_115800.1	Q8NCY6	K1826_HUMAN	Myb/SANT-like DNA-binding domain containing 4 with coiled-coils	304						nucleus											CAGTTGCAAGCGTTCTCGCTC	0.418000													6	89					0	0	1	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45888900	45888900	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45888900G>A	ENST00000418234.2	-	11	2246	c.2168C>T	c.(2167-2169)aCg>aTg	p.T723M	PPP1R13L_ENST00000360957.5_Missense_Mutation_p.T723M	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	723					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GTCGCTGAGCGTGGTGGCGAA	0.667000													5	15					0	0	1	0	0
TEC	7006	broad.mit.edu	37	4	48147115	48147115	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:48147115C>T	ENST00000381501.3	-	14	1608	c.1451G>A	c.(1450-1452)aGc>aAc	p.S484N	TEC_ENST00000511471.2_5'UTR	NM_003215.2	NP_003206.2	P42680	TEC_HUMAN	tec protein tyrosine kinase	484	Protein kinase.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31						GTGGATGAAGCTGTTTCTCTC	0.458000													43	62					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890602	229890602	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:229890602C>T	ENST00000392054.3	-	4	832	c.493G>A	c.(493-495)Gcc>Acc	p.A165T	PID1_ENST00000409462.1_Missense_Mutation_p.A85T|PID1_ENST00000392055.3_Missense_Mutation_p.A134T|PID1_ENST00000482518.2_Intron|PID1_ENST00000354069.6_Missense_Mutation_p.A167T	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	167	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GTGCAGTAGGCGATGCGGGCC	0.587000													11	48					0	0	1	0	0
ZNF467	168544	broad.mit.edu	37	7	149461873	149461873	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149461873G>A	ENST00000302017.3	-	5	2131	c.1718C>T	c.(1717-1719)cCg>cTg	p.P573L	ZNF467_ENST00000484747.1_Intron	NM_207336.1	NP_997219.1	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	573					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|urinary_tract(1)	13	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCGGCGTCCGGGGCCGCGTG	0.706000													10	13					0	0	1	0	0
NTSR2	23620	broad.mit.edu	37	2	11802117	11802117	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:11802117G>T	ENST00000306928.5	-	2	908	c.874C>A	c.(874-876)Ctc>Atc	p.L292I		NM_012344.3	NP_036476.1	O95665	NTR2_HUMAN	neurotensin receptor 2	292					sensory perception	integral to plasma membrane				breast(1)|large_intestine(7)|lung(7)|prostate(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	CTGCGCTGGAGGCTGCGGATC	0.582000													18	52					1.15919e-05	1.19923e-05	1	1	0
NTRK1	4914	broad.mit.edu	37	1	156846355	156846355	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156846355G>A	ENST00000368196.3	+	13	1898	c.1778G>A	c.(1777-1779)cGc>cAc	p.R593H	NTRK1_ENST00000392302.2_Missense_Mutation_p.R563H|NTRK1_ENST00000358660.3_Missense_Mutation_p.R596H|NTRK1_ENST00000524377.1_Missense_Mutation_p.R599H	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	599	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GACCTCAACCGCTTCCTCCGG	0.637000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			7	9					0	0	1	0	0
TTLL3	26140	broad.mit.edu	37	3	9868895	9868895	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9868895G>A	ENST00000383827.1	+	3	2734	c.453G>A	c.(451-453)acG>acA	p.T151T	TTLL3_ENST00000455274.1_Silent_p.T151T|TTLL3_ENST00000547186.1_Silent_p.T363T|ARPC4-TTLL3_ENST00000397256.1_Silent_p.T424T|TTLL3_ENST00000466245.1_Intron|TTLL3_ENST00000397241.1_Silent_p.T151T|TTLL3_ENST00000427853.3_Silent_p.T151T|TTLL3_ENST00000426895.4_Silent_p.T506T|TTLL3_ENST00000430793.1_Silent_p.T151T			Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	363	TTL.				axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	Medulloblastoma(99;0.227)					GCTTTTCCACGCAGCCCTTCT	0.562000													7	39					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123983470	123983470	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:123983470C>T	ENST00000306315.5	-	4	3042	c.2607G>A	c.(2605-2607)tcG>tcA	p.S869S	ZNF608_ENST00000504926.1_Silent_p.S442S	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	869						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CCTGAGACTCCGACAGTCCAT	0.517000													47	57					0	0	1	0	0
POLR3F	10621	broad.mit.edu	37	20	18464142	18464142	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:18464142C>T	ENST00000377603.4	+	9	1271	c.891C>T	c.(889-891)caC>caT	p.H297H	POLR3F_ENST00000462997.1_3'UTR	NM_006466.2	NP_006457.2	Q9H1D9	RPC6_HUMAN	polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa	297					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|protein binding			breast(2)	2						ATGACTGCCACGAAGGTGGTG	0.289000													34	59					0	0	1	0	0
CASP9	842	broad.mit.edu	37	1	15844776	15844776	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:15844776C>A	ENST00000546424.1	-	2	491	c.247G>T	c.(247-249)Gac>Tac	p.D83Y	CASP9_ENST00000333868.5_Missense_Mutation_p.D83Y|CASP9_ENST00000348549.5_Missense_Mutation_p.D83Y|CASP9_ENST00000375890.4_5'UTR|CASP9_ENST00000469637.1_5'UTR			P55211	CASP9_HUMAN	caspase 9, apoptosis-related cysteine peptidase	83	CARD.				activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|stomach(1)	18		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		GCCAGCATGTCCTGGCCTGTG	0.537000													25	41					6.32553e-13	6.85852e-13	1	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72152319	72152319	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:72152319C>A	ENST00000555818.1	+	10	3693	c.3345C>A	c.(3343-3345)atC>atA	p.I1115I	SIPA1L1_ENST00000358550.2_Silent_p.I1115I|SIPA1L1_ENST00000381232.3_Silent_p.I1115I|SIPA1L1_ENST00000537413.1_Silent_p.I590I	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1115					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CTCGAAGCATCTCCAGTGACG	0.552000													14	22					1.99824e-07	2.09433e-07	1	1	0
NUP210	23225	broad.mit.edu	37	3	13418955	13418955	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:13418955C>T	ENST00000254508.5	-	9	1235		c.e9+1			NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CAGGCACTCACGTCAGATACA	0.572000													46	77					0	0	1	0	0
TRIM2	23321	broad.mit.edu	37	4	154216756	154216756	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:154216756G>A	ENST00000338700.5	+	6	1143	c.1078G>A	c.(1078-1080)Gag>Aag	p.E360K	TRIM2_ENST00000437508.2_Missense_Mutation_p.E333K|TRIM2_ENST00000494872.1_3'UTR	NM_015271.3	NP_056086.2	Q9C040	TRIM2_HUMAN	tripartite motif containing 2	333						cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)	19	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		GGCCACGGGCGAGGGGCTGCG	0.597000													11	13					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43766908	43766908	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43766908G>A	ENST00000263801.3	-	10	1380	c.1128C>T	c.(1126-1128)atC>atT	p.I376I	TP53BP1_ENST00000450115.2_Silent_p.I381I|TP53BP1_ENST00000382039.3_Silent_p.I381I|TP53BP1_ENST00000382044.4_Silent_p.I381I	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	376					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TGCTAGGAACGATAAAAGGAG	0.423000								Other conserved DNA damage response genes					13	19					0	0	1	0	0
T	6862	broad.mit.edu	37	6	166578323	166578323	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:166578323A>G	ENST00000296946.2	-	5	1101	c.633T>C	c.(631-633)aaT>aaC	p.N211N	T_ENST00000366871.3_Silent_p.N211N	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	211					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		TTGCAAATGGATTGTACTTAA	0.343000									Chordoma, Familial Clustering of				25	55					0	0	1	0	0
TCF3	6929	broad.mit.edu	37	19	1615322	1615322	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1615322G>A	ENST00000262965.5	-	18	2128	c.1784C>T	c.(1783-1785)gCt>gTt	p.A595V	TCF3_ENST00000395423.3_Missense_Mutation_p.A599V|TCF3_ENST00000588136.1_Intron|TCF3_ENST00000344749.5_Intron|TCF3_ENST00000453954.2_Intron	NM_003200.3	NP_003191.1	P15923	TFE2_HUMAN	transcription factor 3	595	Helix-loop-helix motif.				B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACCGAGACAGCCTGGTGCAG	0.632000			T	"""PBX1, HLF, TFPT"""	pre B-ALL								14	47					0	0	1	0	0
PSEN2	5664	broad.mit.edu	37	1	227083146	227083146	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:227083146C>T	ENST00000366782.1	+	13	1812	c.1312C>T	c.(1312-1314)Ctg>Ttg	p.L438L	PSEN2_ENST00000471728.1_3'UTR|PSEN2_ENST00000391872.2_Silent_p.L438L|PSEN2_ENST00000422240.2_Silent_p.L404L|PSEN2_ENST00000340188.4_Silent_p.L372L|PSEN2_ENST00000366783.3_Silent_p.L405L|PSEN2_ENST00000472139.2_Silent_p.L261L			P49810	PSN2_HUMAN	presenilin 2 (Alzheimer disease 4)	405				NLVRPFMDTLASHQLYI -> RKHSRFIQMN (in Ref. 3).	amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding	p.L405L(1)		cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|urinary_tract(1)	20		Prostate(94;0.0771)				GACCCTCCTGCTGCTTGCTGT	0.602000													11	14					0	0	1	0	0
GIT1	28964	broad.mit.edu	37	17	27903137	27903137	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27903137C>T	ENST00000225394.3	-	15	1872	c.1624G>A	c.(1624-1626)Gac>Aac	p.D542N	RP11-68I3.2_ENST00000581474.1_RNA|GIT1_ENST00000394869.3_Missense_Mutation_p.D551N|GIT1_ENST00000579937.1_Missense_Mutation_p.D542N|GIT1_ENST00000581348.1_Missense_Mutation_p.D551N	NM_014030.3	NP_054749.2	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 1	542					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding			large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		TAGATGGCGTCGTCCTCTAGC	0.607000													20	26					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72883849	72883849	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:72883849C>T	ENST00000339594.4	-	9	3202	c.2864G>A	c.(2863-2865)cGc>cAc	p.R955H	BAZ1B_ENST00000404251.1_Missense_Mutation_p.R955H	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	955					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				ATACTCACTGCGAGGACAGTA	0.423000													10	40					0	0	1	0	0
SLC3A1	6519	broad.mit.edu	37	2	44541027	44541027	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:44541027T>C	ENST00000260649.6	+	9	1630	c.1554T>C	c.(1552-1554)ggT>ggC	p.G518G	SLC3A1_ENST00000409294.1_Silent_p.G138G|SLC3A1_ENST00000409740.3_Silent_p.G149G|SLC3A1_ENST00000409387.1_Silent_p.G518G|SLC3A1_ENST00000409380.1_Silent_p.G240G|SLC3A1_ENST00000409229.3_Silent_p.G518G	NM_000341.3	NP_000332.2	Q07837	SLC31_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 1	518					carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(3)	26		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	CAAATGCTGGTTTTTCTGAAG	0.368000													27	40					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7373783	7373783	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:7373783C>T	ENST00000502583.1	-	5	1833	c.1269G>A	c.(1267-1269)agG>agA	p.R423R	CAGE1_ENST00000296742.7_Silent_p.R287R|CAGE1_ENST00000379918.4_Silent_p.R423R|CAGE1_ENST00000512086.1_Silent_p.R423R|CAGE1_ENST00000338150.4_Silent_p.R423R	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	423										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					CAGTCATGTACCTTTCCTGTA	0.348000													7	22					0	0	1	0	0
RNF19B	127544	broad.mit.edu	37	1	33402616	33402616	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33402616G>A	ENST00000373456.7	-	9	1989	c.1990C>T	c.(1990-1992)Cgc>Tgc	p.R664C	RNF19B_ENST00000356990.5_3'UTR|RNF19B_ENST00000235150.4_Missense_Mutation_p.R663C	NM_153341.2	NP_699172.2	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B	664						integral to membrane	ligase activity|protein binding|zinc ion binding	p.R473S(1)		endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				AGGTCACTGCGGATGCTTTCA	0.582000													36	40					0	0	1	0	0
ZNF507	22847	broad.mit.edu	37	19	32845370	32845370	+	Missense_Mutation	SNP	C	C	T	rs146402867	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:32845370C>T	ENST00000311921.3	+	2	1826	c.1634C>T	c.(1633-1635)tCg>tTg	p.S545L	ZNF507_ENST00000544431.1_Missense_Mutation_p.S545L|ZNF507_ENST00000587084.1_3'UTR|ZNF507_ENST00000355898.5_Missense_Mutation_p.S545L	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	545					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S545L(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					AAAATGATGTCGCCACTTAAA	0.443000													20	44					0	0	1	0	0
RBBP8	5932	broad.mit.edu	37	18	20562337	20562337	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:20562337G>T	ENST00000399722.2	+	7	936	c.585G>T	c.(583-585)gaG>gaT	p.E195D	RBBP8_ENST00000585177.1_3'UTR|RBBP8_ENST00000327155.5_Missense_Mutation_p.E195D|RBBP8_ENST00000360790.5_Missense_Mutation_p.E195D|RBBP8_ENST00000399725.2_Missense_Mutation_p.E195D	NM_203291.1	NP_976036.1	Q99708	COM1_HUMAN	retinoblastoma binding protein 8	195					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			central_nervous_system(1)|cervix(2)|endometrium(5)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	24	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			CTAAATTGGAGCACTCTGTGT	0.388000								Homologous recombination					5	68					0.184627	0.185007	1	1	0
RRN3P2	0	broad.mit.edu	37	16	29113395	29113395	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:29113395C>A	ENST00000564580.1	+	0	1295																											CTGGAGGAGACTCAGTGCAGA	0.498000													16	15					3.45872e-05	3.56558e-05	1	1	0
DMBT1	1755	broad.mit.edu	37	10	124380768	124380768	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:124380768G>A	ENST00000338354.3	+	41	5199	c.5093G>A	c.(5092-5094)gGc>gAc	p.G1698D	DMBT1_ENST00000344338.3_Missense_Mutation_p.G1688D|DMBT1_ENST00000368909.3_Missense_Mutation_p.G1698D|DMBT1_ENST00000368955.3_Missense_Mutation_p.G1688D|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Missense_Mutation_p.G1070D|DMBT1_ENST00000368956.2_Missense_Mutation_p.G1070D			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1698	SRCR 13.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTTGGCCAGGGCTCAGGACCC	0.607000													74	118					0	0	1	0	0
PHF12	57649	broad.mit.edu	37	17	27237109	27237109	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27237109C>T	ENST00000577226.1	-	11	2840	c.2494G>A	c.(2494-2496)Gca>Aca	p.A832T	PHF12_ENST00000582655.1_5'UTR|PHF12_ENST00000332830.4_Intron			Q96QT6	PHF12_HUMAN	PHD finger protein 12	0	FHA.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			AACCATGGTGCTTTATTAAGC	0.443000													3	2					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62631466	62631466	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:62631466A>G	ENST00000383710.4	-	6	1605	c.1256T>C	c.(1255-1257)gTa>gCa	p.V419A	CADPS_ENST00000283269.9_Missense_Mutation_p.V419A|CADPS_ENST00000357948.3_Missense_Mutation_p.V419A|CADPS_ENST00000490353.2_Missense_Mutation_p.V419A	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	419	C2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TGTGCAATATACGATGCGATT	0.458000													4	110					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164777791	164777791	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:164777791C>A	ENST00000264382.3	-	10	1107	c.1045G>T	c.(1045-1047)Gca>Tca	p.A349S		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	349	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity	p.A349T(1)		NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTCCAATATGCTGGCATTGCT	0.363000										HNSCC(35;0.089)			65	103					6.20203e-27	6.93455e-27	1	1	0
PPP1R9A	55607	broad.mit.edu	37	7	94855316	94855316	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:94855316C>A	ENST00000289495.5	+	6	2150	c.1934C>A	c.(1933-1935)cCt>cAt	p.P645H	PPP1R9A_ENST00000340694.4_Missense_Mutation_p.P645H|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.P645H|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.P645H|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.P645H|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.P667H	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	645	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GAGGTAGGACCTGTCCTTCCT	0.498000										HNSCC(28;0.073)			16	29					2.23348e-06	2.32236e-06	1	1	0
PELO	53918	broad.mit.edu	37	5	52096504	52096504	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:52096504G>T	ENST00000274311.2	+	2	1261	c.276G>T	c.(274-276)gaG>gaT	p.E92D	ITGA1_ENST00000282588.6_Intron|PELO_ENST00000506949.1_Intron|ITGA1_ENST00000504086.1_Intron	NM_015946.4	NP_057030.3	Q9BRX2	PELO_HUMAN	pelota homolog (Drosophila)	92					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	11		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				AAGAGAATGAGTATGTCAAGA	0.587000													15	14					1.15088e-07	1.20771e-07	1	1	0
KIAA0100	9703	broad.mit.edu	37	17	26948163	26948163	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26948163C>A	ENST00000528896.2	-	28	5159	c.5085G>T	c.(5083-5085)caG>caT	p.Q1695H	KIAA0100_ENST00000544884.1_Missense_Mutation_p.Q1552H|KIAA0100_ENST00000389003.3_Missense_Mutation_p.Q1552H	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	1695						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					GCTGGGCTTGCTGTGCCTCAG	0.453000													18	37					6.33239e-15	6.92311e-15	1	1	0
FRMD7	90167	broad.mit.edu	37	X	131219626	131219626	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:131219626C>A	ENST00000298542.4	-	7	803	c.628G>T	c.(628-630)Gga>Tga	p.G210*	FRMD7_ENST00000464296.1_Nonsense_Mutation_p.G195*|FRMD7_ENST00000370879.1_Nonsense_Mutation_p.G90*	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	210	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					ACCAGTACTCCCATGTGAGCA	0.507000													5	60					0.0215528	0.0217053	1	1	0
CNTN3	5067	broad.mit.edu	37	3	74414810	74414810	+	Silent	SNP	G	G	A	rs138191723	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:74414810G>A	ENST00000263665.6	-	8	1017	c.990C>T	c.(988-990)gcC>gcT	p.A330A		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	330	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TGTCCTCCACGGCTATTTCCA	0.453000													67	125					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179424206	179424206	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179424206G>A	ENST00000589042.1	-	326	86877	c.86653C>T	c.(86653-86655)Cgt>Tgt	p.R28885C	TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R20012C|TTN_ENST00000591111.1_Missense_Mutation_p.R27244C|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R19820C|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R26317C|TTN_ENST00000359218.5_Missense_Mutation_p.R19945C|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	27244	Ig-like 133.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGCCTCACGTTTTTCTATG	0.438000													27	40					0	0	1	0	0
SLC16A12	387700	broad.mit.edu	37	10	91198529	91198529	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:91198529G>A	ENST00000341233.4	-	6	1160	c.770C>T	c.(769-771)gCc>gTc	p.A257V	SLC16A12_ENST00000371790.4_Missense_Mutation_p.A287V	NM_213606.3	NP_998771.3	Q6ZSM3	MOT12_HUMAN	solute carrier family 16, member 12	257						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						AACGGAGACGGCTAACACAAC	0.453000													25	26					0	0	1	0	0
GGT7	2686	broad.mit.edu	37	20	33447281	33447281	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:33447281C>T	ENST00000336431.5	-	7	1023	c.979G>A	c.(979-981)Gca>Aca	p.A327T		NM_178026.2	NP_821158.2	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	327					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			NS(2)|breast(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)	20						TTGCCACCTGCGTAGAAGGCA	0.662000													6	5					0	0	1	0	0
PPP5C	5536	broad.mit.edu	37	19	46857144	46857144	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46857144G>A	ENST00000012443.4	+	2	364	c.261G>A	c.(259-261)cgG>cgA	p.R87R	PPP5C_ENST00000391919.1_5'UTR	NM_006247.3	NP_006238.1	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	87					mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			endometrium(4)|kidney(1)|large_intestine(5)|liver(2)|lung(4)|ovary(1)|pancreas(1)	18		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		ACGCCACGCGGGCCATTGAGC	0.612000													4	4					0	0	1	0	0
DPEP2	64174	broad.mit.edu	37	16	68024872	68024872	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:68024872C>T	ENST00000412757.2	-	8	1426	c.761G>A	c.(760-762)gGc>gAc	p.G254D	DPEP2_ENST00000393847.1_Missense_Mutation_p.G254D|DPEP2_ENST00000572888.1_Missense_Mutation_p.G254D			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	254					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TACCATCATGCCCAGGCGGTT	0.547000													14	60					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208216471	208216471	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:208216471G>A	ENST00000367033.3	-	21	4709	c.3952C>T	c.(3952-3954)Cgt>Tgt	p.R1318C		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1318					axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GCGTAGGTACGATAGTCCAGG	0.582000													12	17					0	0	1	0	0
C1QTNF9	338872	broad.mit.edu	37	13	24890279	24890279	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:24890279C>T	ENST00000382071.2	+	2	223	c.138C>T	c.(136-138)gaC>gaT	p.D46D	C1QTNF9_ENST00000332018.4_Silent_p.D46D|C1QTNF9-AS1_ENST00000449656.1_RNA			P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	46	Collagen-like 1.					collagen	hormone activity			endometrium(1)|kidney(2)|lung(6)	9		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		ATGGACGAGACGGAGCGAAGG	0.542000													24	21					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35449064	35449064	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35449064G>A	ENST00000404801.1	-	4	2081	c.1695C>T	c.(1693-1695)agC>agT	p.S565S	ZNF792_ENST00000605484.1_Silent_p.S498S	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TCCCACATTCGCTGCATTCGT	0.507000													3	21					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121454219	121454219	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:121454219C>T	ENST00000260197.7	+	26	3762	c.3633C>T	c.(3631-3633)tgC>tgT	p.C1211C	SORL1_ENST00000525532.1_Silent_p.C155C|SORL1_ENST00000532694.1_Silent_p.C57C|SORL1_ENST00000534286.1_Silent_p.C121C	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1211	LDL-receptor class A 4.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ACGGGCACTGCATCCCCCAGC	0.577000													6	13					0	0	1	0	0
ZC3H10	84872	broad.mit.edu	37	12	56514903	56514903	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56514903G>A	ENST00000257940.2	+	3	833	c.557G>A	c.(556-558)cGt>cAt	p.R186H	RP11-603J24.5_ENST00000550947.1_RNA|RP11-603J24.5_ENST00000549438.1_RNA	NM_032786.1	NP_116175.1	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	186							nucleic acid binding|zinc ion binding			breast(1)|endometrium(4)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	11			OV - Ovarian serous cystadenocarcinoma(18;0.12)			CCAGGACGACGTCATGATCTC	0.582000													17	33					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114278439	114278439	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:114278439G>A	ENST00000357077.4	+	38	8718	c.8665G>A	c.(8665-8667)Gac>Aac	p.D2889N	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.D2856N|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2856					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTTACCAAAGGACTGCCCCTC	0.383000													39	53					0	0	1	0	0
SPTBN1	0	broad.mit.edu	37	2	54858170	54858170	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:54858170C>T	ENST00000333896.5	+	15	3332	c.2947C>T	c.(2947-2949)Cgc>Tgc	p.R983C	SPTBN1_ENST00000356805.4_Missense_Mutation_p.R996C	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	996					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GGCCCTGCAGCGCAAGCTGAC	0.602000													10	18					0	0	1	0	0
ARL11	115761	broad.mit.edu	37	13	50204664	50204664	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:50204664G>A	ENST00000282026.1	+	2	416	c.81G>A	c.(79-81)acG>acA	p.T27T	ARL11_ENST00000490932.1_Intron	NM_138450.5	NP_612459.1	Q969Q4	ARL11_HUMAN	ADP-ribosylation factor-like 11	27					small GTPase mediated signal transduction	intracellular	GTP binding|protein binding			kidney(1)|large_intestine(4)|ovary(1)	6		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.119)|Kidney(9;0.169)	GBM - Glioblastoma multiforme(99;1.67e-09)		GCAAGACCACGCTCCTTTACA	0.592000													24	25					0	0	1	0	0
ZNF324	25799	broad.mit.edu	37	19	58981203	58981203	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58981203G>A	ENST00000536459.2	+	3	939	c.230G>A	c.(229-231)cGc>cAc	p.R77H	ZNF324_ENST00000196482.3_Missense_Mutation_p.R77H			O75467	Z324A_HUMAN	zinc finger protein 324	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TACAGGAGGCGCAACCCTGGT	0.622000													3	2					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127235682	127235682	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:127235682T>C	ENST00000265825.5	+	2	685	c.466T>C	c.(466-468)Tat>Cat	p.Y156H	FSCN3_ENST00000420086.2_Missense_Mutation_p.Y22H	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	156						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						CCACCGCTGCTATGCCCGGGC	0.607000													14	23					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32138302	32138302	+	Silent	SNP	C	C	T	rs138560989		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:32138302C>T	ENST00000312561.4	+	4	4827	c.4413C>T	c.(4411-4413)aaC>aaT	p.N1471N	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		GTGTGAAAAACGTGCCATGTG	0.398000													25	40					0	0	1	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161165296	161165296	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161165296C>T	ENST00000367996.4	-	4	1648	c.1220G>A	c.(1219-1221)tGc>tAc	p.C407Y	ADAMTS4_ENST00000478394.1_5'UTR	NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	407	Peptidase M12B.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GCGGGCACTGCAGGGGGACCA	0.562000													29	47					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2659184	2659184	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:2659184G>A	ENST00000399655.1	+	10	1731	c.1466G>A	c.(1465-1467)tGc>tAc	p.C489Y	CACNA1C_ENST00000491104.1_3'UTR|CACNA1C_ENST00000327702.7_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399601.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399638.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000335762.5_Missense_Mutation_p.C514Y|CACNA1C_ENST00000406454.3_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399644.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399591.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399595.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399606.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399597.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000402845.3_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399617.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399634.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399603.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000480911.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399637.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399621.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000347598.4_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399649.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399629.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000399641.1_Missense_Mutation_p.C489Y|CACNA1C_ENST00000344100.3_Missense_Mutation_p.C489Y	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	489					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGAGAAAACTGCGGGGCCAGG	0.597000													4	4					0	0	1	0	0
ZNF184	7738	broad.mit.edu	37	6	27421019	27421019	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:27421019T>C	ENST00000211936.6	-	6	603	c.319A>G	c.(319-321)Aat>Gat	p.N107D	ZNF184_ENST00000377419.1_Missense_Mutation_p.N107D	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						GACACACTATTTTCAAGTCTT	0.363000													6	55					0	0	1	0	0
MSX2	4488	broad.mit.edu	37	5	174156454	174156454	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:174156454C>T	ENST00000239243.6	+	2	799	c.672C>T	c.(670-672)ttC>ttT	p.F224F		NM_002449.4	NP_002440.2	P35548	MSX2_HUMAN	msh homeobox 2	224					cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GTCTCCCTTTCCCCATCAGCT	0.567000													14	24					0	0	1	0	0
PACS2	23241	broad.mit.edu	37	14	105849203	105849203	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105849203G>A	ENST00000447393.1	+	15	1753	c.1578G>A	c.(1576-1578)gcG>gcA	p.A526A	PACS2_ENST00000547217.1_Silent_p.A492A|PACS2_ENST00000325438.8_Silent_p.A522A|PACS2_ENST00000430725.2_Silent_p.A447A|PACS2_ENST00000458164.2_Silent_p.A526A	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	522					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GCTCTCCTGCGGACGTCCAGG	0.637000													10	16					0	0	1	0	0
PEAR1	375033	broad.mit.edu	37	1	156878721	156878721	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156878721C>G	ENST00000338302.3	+	12	1529	c.1304C>G	c.(1303-1305)gCt>gGt	p.A435G	PEAR1_ENST00000292357.7_Missense_Mutation_p.A435G			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	435	EGF-like 5.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCTCACTGTGCTAGTCTTTGT	0.627000													18	20					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234106794	234106794	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:234106794T>C	ENST00000359570.5	+	27	2711	c.2711T>C	c.(2710-2712)aTg>aCg	p.M904T	INPP5D_ENST00000455936.2_Missense_Mutation_p.M668T|INPP5D_ENST00000450745.1_Missense_Mutation_p.M668T			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	916					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CCCAACTACATGGGAGTGGGG	0.622000													9	11					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57863392	57863392	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57863392G>A	ENST00000228682.2	+	11	1578	c.1487G>A	c.(1486-1488)cGc>cAc	p.R496H	GLI1_ENST00000546141.1_Missense_Mutation_p.R455H|GLI1_ENST00000543426.1_Missense_Mutation_p.R368H	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	496					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			TCCACTCTTCGCCGCCTTGAG	0.597000													32	25					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84203534	84203534	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:84203534G>T	ENST00000378553.5	+	8	1224	c.1100G>T	c.(1099-1101)gGg>gTg	p.G367V	DNAAF1_ENST00000334315.5_Missense_Mutation_p.G367V|DNAAF1_ENST00000563818.1_3'UTR	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	367					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						GAGCCTCCCGGGGACAGAGAA	0.537000													23	18					9.86323e-18	1.08645e-17	1	1	0
PTPN1	5770	broad.mit.edu	37	20	49191125	49191125	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:49191125A>G	ENST00000371621.3	+	5	600	c.426A>G	c.(424-426)ttA>ttG	p.L142L	PTPN1_ENST00000541713.1_Silent_p.L69L|RP4-530I15.9_ENST00000431019.1_RNA	NM_001278618.1|NM_002827.2	NP_001265547.1|NP_002818.1	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type 1	142	Tyrosine-protein phosphatase.				blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(2)	16		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	atttgaaattaacattgatct	0.358000													18	36					0	0	1	0	0
KIAA1598	57698	broad.mit.edu	37	10	118738784	118738784	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118738784G>A	ENST00000355371.4	-	2	591	c.94C>T	c.(94-96)Cag>Tag	p.Q32*	KIAA1598_ENST00000392903.2_Nonsense_Mutation_p.Q32*|KIAA1598_ENST00000260777.10_Nonsense_Mutation_p.Q32*|KIAA1598_ENST00000392901.4_5'UTR	NM_001127211.2|NM_001258298.1|NM_001258299.1	NP_001120683.1|NP_001245227.1|NP_001245228.1	A0MZ66	SHOT1_HUMAN	KIAA1598	32					axon guidance	axon				endometrium(1)|kidney(1)|large_intestine(5)|lung(3)	10				all cancers(201;0.00494)		TTTGTTTTCTGGTTCTCTGCT	0.398000													15	26					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7672925	7672925	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7672925G>A	ENST00000299492.4	+	23	2674	c.2286G>A	c.(2284-2286)atG>atA	p.M762I	PPFIBP2_ENST00000530181.1_Missense_Mutation_p.M619I|PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000533792.1_Missense_Mutation_p.M604I|PPFIBP2_ENST00000528883.1_Missense_Mutation_p.M650I	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	762	SAM 3.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CCCTGGCTATGCTTCTCAACA	0.562000													35	47					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131136321	131136321	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:131136321A>G	ENST00000357668.1	-	17	1572	c.1545T>C	c.(1543-1545)ttT>ttC	p.F515F	ASAP1_ENST00000518721.1_Silent_p.F515F			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	515	Arf-GAP.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						TAATATCATTAAAACTATTGT	0.328000													13	27					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63554079	63554079	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:63554079G>A	ENST00000307078.5	-	2	973	c.660C>T	c.(658-660)gtC>gtT	p.V220V	AXIN2_ENST00000375702.5_Silent_p.V220V|CTD-2535L24.2_ENST00000577662.1_3'UTR	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	220					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						AGCCACACACGACCTTTAGGC	0.483000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				34	45					0	0	1	0	0
TGFB2	7042	broad.mit.edu	37	1	218578521	218578521	+	Silent	SNP	G	G	A	rs138514914		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:218578521G>A	ENST00000366929.4	+	3	908	c.441G>A	c.(439-441)ccG>ccA	p.P147P	TGFB2_ENST00000366930.4_Silent_p.P119P	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	119					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		ATGCCATCCCGCCCACTTTCT	0.403000													86	102					0	0	1	0	0
GPR148	344561	broad.mit.edu	37	2	131487316	131487316	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:131487316G>T	ENST00000309926.4	+	1	674	c.592G>T	c.(592-594)Gga>Tga	p.G198*		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	198						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					GGAGGAGCAAGGAGCTTCATA	0.577000													15	25					3.27435e-08	3.44876e-08	1	1	0
CCDC103	388389	broad.mit.edu	37	17	42979959	42979959	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42979959G>A	ENST00000417826.2	+	4	598	c.503G>A	c.(502-504)tGc>tAc	p.C168Y	CCDC103_ENST00000410006.2_Missense_Mutation_p.C168Y|FAM187A_ENST00000331733.4_5'UTR|FAM187A_ENST00000412523.2_Intron	NM_001258399.1|NM_213607.2	NP_001245328.1|NP_998772.1	Q8IW40	CC103_HUMAN	coiled-coil domain containing 103	168										endometrium(1)|kidney(1)|large_intestine(3)|prostate(1)|skin(1)	7		Prostate(33;0.109)				GGGATCCTATGCAGCCTGGCG	0.617000													16	35					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149477549	149477549	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149477549C>T	ENST00000378016.2	+	0	1620							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACACCGTGCGCCAGCTGTGTA	0.642000													9	12					0	0	1	0	0
MPL	4352	broad.mit.edu	37	1	43812590	43812590	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43812590C>T	ENST00000372470.3	+	8	1335	c.1293C>T	c.(1291-1293)ggC>ggT	p.G431G	MPL_ENST00000413998.2_Silent_p.G431G	NM_005373.2	NP_005364.1	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	431	Fibronectin type-III 2.				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(551)|large_intestine(3)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	567	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CAGGAGAAGGCCATCAGGACT	0.562000			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						19	22					0	0	1	0	0
CPT2	1376	broad.mit.edu	37	1	53679043	53679043	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:53679043A>G	ENST00000371486.3	+	5	2268	c.1753A>G	c.(1753-1755)Aat>Gat	p.N585D	RP5-1024G6.2_ENST00000452466.1_RNA	NM_000098.2	NP_000089.1	P23786	CPT2_HUMAN	carnitine palmitoyltransferase 2	585					carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	15					L-Carnitine(DB00583)|Perhexiline(DB01074)	GATAAACCACAATGTCCTGTC	0.552000													35	83					0	0	1	0	0
KY	339855	broad.mit.edu	37	3	134322744	134322744	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:134322744G>A	ENST00000508956.1	-	10	1657	c.1600C>T	c.(1600-1602)Ctt>Ttt	p.L534F	KY_ENST00000423778.2_Missense_Mutation_p.L555F|KY_ENST00000503669.1_3'UTR			Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	557						cytoskeleton|Z disc	peptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|lung(12)|ovary(2)|upper_aerodigestive_tract(2)	21						CAGCATACAAGGTAATTAAAG	0.512000													4	38					0	0	1	0	0
DDHD1	0	broad.mit.edu	37	14	53539389	53539389	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:53539389G>A	ENST00000357758.3	-	6	1612	c.1429C>T	c.(1429-1431)Cga>Tga	p.R477*	DDHD1_ENST00000323669.5_Nonsense_Mutation_p.R477*|DDHD1_ENST00000395606.1_Nonsense_Mutation_p.R484*	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	477					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					CTTAAACCTCGTACTTTGTCA	0.343000													59	92					0	0	1	0	0
PTBP1	5725	broad.mit.edu	37	19	805040	805040	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:805040G>A	ENST00000356948.6	+	8	1168	c.745G>A	c.(745-747)Gcc>Acc	p.A249T	PTBP1_ENST00000394601.4_Missense_Mutation_p.A249T|PTBP1_ENST00000350092.4_Intron|PTBP1_ENST00000349038.4_Missense_Mutation_p.A249T	NM_002819.4	NP_002810.1	P26599	PTBP1_HUMAN	polypyrimidine tract binding protein 1	249	RRM 2.				negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)	19		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CATCTACAACGCCTGCTGCAC	0.642000													42	51					0	0	1	0	0
ATP5C1	509	broad.mit.edu	37	10	7844330	7844330	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:7844330C>A	ENST00000356708.7	+	7	814	c.735C>A	c.(733-735)tcC>tcA	p.S245S	ATP5C1_ENST00000541227.1_Silent_p.S198S|ATP5C1_ENST00000493053.1_3'UTR|ATP5C1_ENST00000335698.4_Silent_p.S245S	NM_001001973.1	NP_001001973.1	P36542	ATPG_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	245					oxidative phosphorylation|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(2)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	16						TGAAGGAGTCCACCACTAGTG	0.468000													11	27					3.86212e-05	3.97146e-05	1	1	0
ZNF692	55657	broad.mit.edu	37	1	249150039	249150039	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:249150039G>A	ENST00000451251.1	-	7	1126	c.781C>T	c.(781-783)Ccg>Tcg	p.P261S	ZNF692_ENST00000366469.5_Missense_Mutation_p.P255S|ZNF692_ENST00000468455.1_5'UTR|ZNF692_ENST00000427146.1_Missense_Mutation_p.P211S|ZNF692_ENST00000366471.3_Missense_Mutation_p.P211S|ZNF692_ENST00000306601.4_Missense_Mutation_p.P256S	NM_001136036.2	NP_001129508.1	Q9BU19	ZN692_HUMAN	zinc finger protein 692	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)	17	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GACAAGGCCGGCACAGCAAGA	0.622000													17	16					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610124	47610124	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47610124C>T	ENST00000371891.3	+	7	917	c.886C>T	c.(886-888)Ctc>Ttc	p.L296F	CYP4A22_ENST00000485117.1_3'UTR|CYP4A22_ENST00000371890.3_Missense_Mutation_p.P244L|CYP4A22_ENST00000294337.3_Missense_Mutation_p.L296F|CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	296						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GGACATCCTCCTCTTGGCCAA	0.507000													23	54					0	0	1	0	0
RBM48	84060	broad.mit.edu	37	7	92163971	92163971	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:92163971T>C	ENST00000481551.1	+	4	745	c.704T>C	c.(703-705)aTg>aCg	p.M235T	RBM48_ENST00000265732.5_Missense_Mutation_p.M235T			Q5RL73	CG064_HUMAN	RNA binding motif protein 48	235							nucleotide binding										CATAAAACAATGGGGCATTAT	0.428000													21	34					0	0	1	0	0
TRIM37	4591	broad.mit.edu	37	17	57126630	57126630	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:57126630A>G	ENST00000376149.3	-	15	1882	c.1073T>C	c.(1072-1074)aTg>aCg	p.M358T	TRIM37_ENST00000393066.3_Missense_Mutation_p.M480T|TRIM37_ENST00000262294.7_Missense_Mutation_p.M480T|TRIM37_ENST00000393065.2_Missense_Mutation_p.M446T			O94972	TRI37_HUMAN	tripartite motif containing 37	480	MATH.					perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TTCGAGAAGCATGTCAGAGCA	0.433000									Mulibrey Nanism				25	83					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179579944	179579944	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179579944C>A	ENST00000589042.1	-	90	26193	c.25969G>T	c.(25969-25971)Gga>Tga	p.G8657*	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Nonsense_Mutation_p.G8340*|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Nonsense_Mutation_p.G7413*|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8340	Ig-like 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACATCAGCTCCTTTCAGTGTC	0.398000													32	52					7.68411e-24	8.5683e-24	1	1	0
TFCP2	7024	broad.mit.edu	37	12	51512418	51512418	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:51512418G>A	ENST00000307660.4	-	2	980	c.260C>T	c.(259-261)aCg>aTg	p.T87M	TFCP2_ENST00000257915.5_Missense_Mutation_p.T87M|TFCP2_ENST00000548115.1_Missense_Mutation_p.T87M|TFCP2_ENST00000549867.1_Missense_Mutation_p.T87M	NM_001173453.1	NP_001166924.1	Q12800	TFCP2_HUMAN	transcription factor CP2	87					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	23						ATTGAGATACGTTAGGGTTTC	0.383000													24	37					0	0	1	0	0
MGAT2	4247	broad.mit.edu	37	14	50088160	50088160	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:50088160C>A	ENST00000305386.2	+	1	672	c.174C>A	c.(172-174)ccC>ccA	p.P58P	RP11-649E7.5_ENST00000555043.1_RNA	NM_002408.3	NP_002399.1	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	58					oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)	11	all_epithelial(31;0.0021)|Breast(41;0.0124)					GGGACCACCCCTCTGTGGCTG	0.726000													7	15					0.0293803	0.0295506	1	1	0
ERCC6L2	375748	broad.mit.edu	37	9	98774580	98774580	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:98774580G>A	ENST00000407474.3	+	4	1204	c.691G>A	c.(691-693)Gcc>Acc	p.A231T				Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	0	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										TATAACCAATGCCACATCAGA	0.318000													8	16					0	0	1	0	0
ADI1	55256	broad.mit.edu	37	2	3504604	3504604	+	Missense_Mutation	SNP	C	C	T	rs147446974		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:3504604C>T	ENST00000382093.5	-	3	3220	c.383G>A	c.(382-384)cGc>cAc	p.R128H	ADI1_ENST00000327435.6_Missense_Mutation_p.R134H			Q9BV57	MTND_HUMAN	acireductone dioxygenase 1	134					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus|plasma membrane	acireductone dioxygenase (Ni2+-requiring) activity|metal ion binding|protein binding			breast(2)|large_intestine(2)|lung(4)|ovary(1)|stomach(1)	10	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0729)|Epithelial(75;0.173)|all cancers(51;0.228)		CACCGTGAAGCGGTGATAGAT	0.637000													3	8					0	0	1	0	0
TBC1D16	125058	broad.mit.edu	37	17	77926467	77926467	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:77926467G>A	ENST00000310924.2	-	4	1045	c.930C>T	c.(928-930)cgC>cgT	p.R310R		NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	310						intracellular	Rab GTPase activator activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			TGAAGAAAAGGCGGAGGGAGC	0.662000													4	22					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100126320	100126320	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:100126320C>A	ENST00000357054.1	+	41	4792	c.3857C>A	c.(3856-3858)cCt>cAt	p.P1286H	RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000395220.1_3'UTR|CCDC180_ENST00000529487.1_Intron|CCDC180_ENST00000375202.2_Intron					coiled-coil domain containing 180																		ACCCACCCACCTTTGTCCCAC	0.617000													11	18					6.40141e-05	6.5734e-05	1	1	0
ZNF599	148103	broad.mit.edu	37	19	35250255	35250255	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35250255C>T	ENST00000329285.7	-	4	1824	c.1451G>A	c.(1450-1452)tGt>tAt	p.C484Y		NM_001007248.2	NP_001007249.1	Q96NL3	ZN599_HUMAN	zinc finger protein 599	484					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|skin(1)	24	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			GGCTTTTGCACATTCTTTGCA	0.423000													4	126					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40568702	40568702	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:40568702C>T	ENST00000342449.3	-	41	6371	c.6293G>A	c.(6292-6294)gGc>gAc	p.G2098D	BRWD1_ENST00000380800.3_Missense_Mutation_p.G2098D|BRWD1_ENST00000333229.2_Missense_Mutation_p.G2098D	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	2098					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GAGTCTTCTGCCATTCCACCT	0.418000													57	37					0	0	1	0	0
CAPN2	824	broad.mit.edu	37	1	223962541	223962541	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:223962541C>A	ENST00000295006.5	+	21	2394	c.2085C>A	c.(2083-2085)ctC>ctA	p.L695L	CAPN2_ENST00000433674.2_Silent_p.L617L|CAPN2_ENST00000474026.1_3'UTR	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	695	Domain IV.|EF-hand 3.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		CACAGTGGCTCTGTTTCTCAG	0.358000													21	32					3.51602e-12	3.7986e-12	1	1	0
SDHA	6389	broad.mit.edu	37	5	228319	228319	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:228319G>A	ENST00000264932.6	+	6	756	c.641G>A	c.(640-642)aGc>aAc	p.S214N	SDHA_ENST00000510361.1_Missense_Mutation_p.S166N|SDHA_ENST00000504309.1_Missense_Mutation_p.S214N	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	214					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	TATGATACCAGCTATTTTGTG	0.438000									Familial Paragangliomas				19	31					0	0	1	0	0
SLC1A4	6509	broad.mit.edu	37	2	65243578	65243578	+	Missense_Mutation	SNP	G	G	A	rs147292530		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:65243578G>A	ENST00000234256.3	+	5	1048	c.805G>A	c.(805-807)Gta>Ata	p.V269I	SLC1A4_ENST00000493121.1_3'UTR|SLC1A4_ENST00000531327.1_Intron	NM_003038.4	NP_003029.2	P43007	SATT_HUMAN	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	269					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|urinary_tract(1)	13					L-Alanine(DB00160)	CCCTAGGTACGTACCTGTGGG	0.517000													13	43					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43986126	43986126	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:43986126G>T	ENST00000261488.6	-	5	711	c.134C>A	c.(133-135)cCc>cAc	p.P45H	ENOX1_ENST00000412891.1_Missense_Mutation_p.P45H	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	45					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		CCAGGCTGTGGGATCTGTCAC	0.522000													26	21					7.38237e-10	7.86209e-10	1	1	0
LYST	1130	broad.mit.edu	37	1	235944227	235944227	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:235944227G>A	ENST00000389794.3	-	16	5326	c.5152C>T	c.(5152-5154)Cga>Tga	p.R1718*	LYST_ENST00000389793.2_Nonsense_Mutation_p.R1718*|LYST_ENST00000536965.1_3'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1718					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGTTCACATCGCAAAATTTCT	0.294000													5	49					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166245293	166245293	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166245293G>A	ENST00000357398.3	+	27	5267	c.4977G>A	c.(4975-4977)gcG>gcA	p.A1659A	SCN2A_ENST00000375427.2_Silent_p.A1659A|SCN2A_ENST00000283256.6_Silent_p.A1659A|SCN2A_ENST00000375437.2_Silent_p.A1659A			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1659					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CCCTTCCTGCGTTGTTTAACA	0.493000													39	49					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22935875	22935875	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:22935875C>A	ENST00000313077.7	+	9	936	c.811C>A	c.(811-813)Ctg>Atg	p.L271M	CYFIP1_ENST00000560848.1_Missense_Mutation_p.L271M	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	271					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GGGATTTGGTCTGTACCTGAT	0.393000													5	50					0.00198382	0.0020125	1	1	0
SOX3	6658	broad.mit.edu	37	X	139587164	139587164	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:139587164G>A	ENST00000370536.2	-	1	61	c.62C>T	c.(61-63)gCg>gTg	p.A21V		NM_005634.2	NP_005625.2	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	21					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	10	Acute lymphoblastic leukemia(192;7.65e-05)					AATGCTCCGCGCCAAATCAGC	0.622000													5	0					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188977	32188977	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32188977G>A	ENST00000375023.3	-	4	715	c.577C>T	c.(577-579)Cgt>Tgt	p.R193C		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	193					cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity	p.R193C(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						TTGACATCACGTTCACAGGCA	0.617000													10	20					0	0	1	0	0
P4HA3	283208	broad.mit.edu	37	11	74009328	74009328	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:74009328C>T	ENST00000331597.4	-	4	691	c.646G>A	c.(646-648)Gga>Aga	p.G216R	P4HA3_ENST00000427714.2_Missense_Mutation_p.G216R	NM_182904.3	NP_878907.1	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha polypeptide III	216						endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(1)	15	Breast(11;2.31e-05)					TTCCACTCTCCGTAAGATCCT	0.493000													24	51					0	0	1	0	0
ACTR1B	10120	broad.mit.edu	37	2	98275897	98275897	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:98275897C>T	ENST00000289228.5	-	4	449	c.233G>A	c.(232-234)gGc>gAc	p.G78D		NM_005735.3	NP_005726.1	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B, centractin beta (yeast)	78						centrosome|dynactin complex	ATP binding|protein binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	15						TCGCACCACGCCGTGCTCCAT	0.657000													7	142					0	0	1	0	0
GOLPH3	64083	broad.mit.edu	37	5	32126482	32126482	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:32126482C>T	ENST00000265070.6	-	4	1048	c.733G>A	c.(733-735)Gcc>Acc	p.A245T		NM_022130.3	NP_071413.1	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3 (coat-protein)	245					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11						ACGTCCGAGGCATGAGCCAGG	0.537000													14	38					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59212279	59212279	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:59212279C>T	ENST00000262717.4	+	10	1948	c.1550C>T	c.(1549-1551)gCg>gTg	p.A517V	CDH20_ENST00000538374.1_Missense_Mutation_p.A517V|CDH20_ENST00000536675.2_Missense_Mutation_p.A517V			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	517	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				ACAGTGAGTGCGGTGGACCAA	0.517000													27	25					0	0	1	0	0
KAT2A	2648	broad.mit.edu	37	17	40272789	40272789	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40272789C>T	ENST00000225916.5	-	2	451	c.398G>A	c.(397-399)cGc>cAc	p.R133H	CTD-2132N18.3_ENST00000592574.1_Missense_Mutation_p.R167H	NM_021078.2	NP_066564.2	Q92830	KAT2A_HUMAN	K(lysine) acetyltransferase 2A	133					chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity	p.R133H(1)		central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						CAGATCCATGCGGGGTGCAGT	0.602000													18	38					0	0	1	0	0
JAK1	3716	broad.mit.edu	37	1	65309756	65309756	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:65309756C>T	ENST00000342505.4	-	17	2642	c.2394G>A	c.(2392-2394)acG>acA	p.T798T	JAK1_ENST00000465376.1_5'UTR	NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	798	Protein kinase 1.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		CCTCAATCAGCGTCTTGTCTT	0.572000			Mis		ALL								11	30					0	0	1	0	0
RAMP3	10268	broad.mit.edu	37	7	45216944	45216944	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:45216944G>A	ENST00000242249.4	+	2	133	c.95G>A	c.(94-96)gGc>gAc	p.G32D	RAMP3_ENST00000481345.1_Missense_Mutation_p.G32D|RAMP3_ENST00000496212.1_Missense_Mutation_p.G32D	NM_005856.2	NP_005847.1	O60896	RAMP3_HUMAN	receptor (G protein-coupled) activity modifying protein 3	32					intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane|lysosome	protein transporter activity			breast(1)|endometrium(1)|large_intestine(4)|lung(4)|stomach(1)	11					Pramlintide(DB01278)	AACGAGACAGGCATGTTGGAG	0.587000													8	21					0	0	1	0	0
C12orf42	374470	broad.mit.edu	37	12	103696167	103696167	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:103696167C>T	ENST00000548048.1	-	9	1097	c.601G>A	c.(601-603)Gcg>Acg	p.A201T	C12orf42_ENST00000378113.2_Missense_Mutation_p.A268T|C12orf42_ENST00000548883.1_Missense_Mutation_p.A268T|C12orf42_ENST00000315192.8_Intron			Q96LP6	CL042_HUMAN	chromosome 12 open reading frame 42	268								p.A268T(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)	22						TTTCCGGACGCGCCCAGGAGT	0.667000													38	56					0	0	1	0	0
SMYD2	56950	broad.mit.edu	37	1	214504374	214504374	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:214504374A>G	ENST00000366957.5	+	9	920	c.898A>G	c.(898-900)Aac>Gac	p.N300D	SMYD2_ENST00000491455.1_3'UTR|SMYD2_ENST00000415093.2_Intron	NM_020197.2	NP_064582.2	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	300					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		ATATGCACGCAACGTCATTGA	0.498000													26	38					0	0	1	0	0
FAM71E1	112703	broad.mit.edu	37	19	50979390	50979390	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50979390C>T	ENST00000600100.1	-	1	620	c.256G>A	c.(256-258)Gca>Aca	p.A86T	FAM71E1_ENST00000595790.1_Missense_Mutation_p.A86T			Q6IPT2	F71E1_HUMAN	family with sequence similarity 71, member E1	86										breast(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		CTCTCACCTGCCATCCCACCT	0.662000													22	42					0	0	1	0	0
GPR55	9290	broad.mit.edu	37	2	231775353	231775353	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:231775353C>T	ENST00000392040.1	-	2	517	c.325G>A	c.(325-327)Gtc>Atc	p.V109I	GPR55_ENST00000392039.2_Missense_Mutation_p.V109I	NM_005683.3	NP_005674.2	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	109					activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity	p.V109L(1)		endometrium(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		ATGGTGAAGACGCTTCCGTAC	0.582000													9	10					0	0	1	0	0
LPPR3	0	broad.mit.edu	37	19	814746	814746	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:814746C>A	ENST00000359894.2	-	6	666	c.603G>T	c.(601-603)aaG>aaT	p.K201N	LPPR3_ENST00000520876.3_Missense_Mutation_p.K201N	NM_024888.2	NP_079164.1	Q6T4P5	LPPR3_HUMAN		201						integral to membrane	phosphatidate phosphatase activity										ACGGGAAGGTCTTCCTGTAAG	0.672000													4	12					0.014758	0.0148771	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105410919	105410919	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105410919G>A	ENST00000333244.5	-	7	10988	c.10869C>T	c.(10867-10869)gaC>gaT	p.D3623D	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3623						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCAGGGACAGGTCTCCCTCCA	0.592000													78	132					0	0	1	0	0
SNAI3	333929	broad.mit.edu	37	16	88747799	88747799	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:88747799C>T	ENST00000332281.5	-	2	486	c.400G>A	c.(400-402)Ggg>Agg	p.G134R	SNAI3-AS1_ENST00000563261.1_RNA	NM_178310.3	NP_840101.1	Q3KNW1	SNAI3_HUMAN	snail family zinc finger 3	134					oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding	p.G134R(1)		NS(1)|central_nervous_system(1)|kidney(1)|lung(1)|ovary(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(80;0.048)		TCCGGAGCCCCGTGCCGGTCT	0.667000													37	41					0	0	1	0	0
PSAT1	29968	broad.mit.edu	37	9	80915565	80915565	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:80915565C>T	ENST00000376588.3	+	2	176	c.108C>T	c.(106-108)ggC>ggT	p.G36G	PSAT1_ENST00000347159.2_Silent_p.G36G	NM_058179.2	NP_478059.1	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1	36					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	AAGGAGTTGGCATTAGTGTTC	0.308000													22	22					0	0	1	0	0
REEP4	80346	broad.mit.edu	37	8	21996508	21996508	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:21996508C>T	ENST00000306306.3	-	6	952	c.484G>A	c.(484-486)Gca>Aca	p.A162T	REEP4_ENST00000334530.5_Intron|REEP4_ENST00000523293.1_Missense_Mutation_p.A162T	NM_025232.2	NP_079508.2	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	162						integral to membrane				kidney(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	7				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		GGGGCAGGTGCGTCAGAGATG	0.692000													6	5					0	0	1	0	0
FAM13B	0	broad.mit.edu	37	5	137284782	137284782	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137284782G>A	ENST00000033079.3	-	17	2407	c.1956C>T	c.(1954-1956)gaC>gaT	p.D652D	FAM13B_ENST00000425075.2_Silent_p.D556D|FAM13B_ENST00000420893.2_Silent_p.D652D	NM_016603.2	NP_057687.2	Q9NYF5	FA13B_HUMAN	family with sequence similarity 13, member B	652					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(4)|kidney(2)|lung(5)	11						CATCTTCATGGTCTAGAGAAG	0.383000													55	77					0	0	1	0	0
GFM1	85476	broad.mit.edu	37	3	158408054	158408054	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:158408054G>A	ENST00000486715.1	+	16	2369	c.2012G>A	c.(2011-2013)cGc>cAc	p.R671H	GFM1_ENST00000264263.5_Missense_Mutation_p.R690H	NM_024996.5	NP_079272.4	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1	671					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|urinary_tract(2)	22			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			ATTAACCGACGCCATGGGGTA	0.408000													56	110					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15497052	15497052	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:15497052C>T	ENST00000341776.2	+	7	1840	c.1596C>T	c.(1594-1596)tcC>tcT	p.S532S	JARID2_ENST00000397311.3_Silent_p.S360S|JARID2_ENST00000541660.1_Silent_p.S494S	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	532					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AACCGGAGTCCGTGCACAAGC	0.687000													5	9					0	0	1	0	0
PVRL4	81607	broad.mit.edu	37	1	161044461	161044461	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161044461C>T	ENST00000368012.3	-	5	1242	c.940G>A	c.(940-942)Gtc>Atc	p.V314I	PVRL4_ENST00000453926.2_Missense_Mutation_p.V48I	NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	314	Ig-like C2-type 2.				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			ACATGGCAGACGTAGATGCCG	0.572000													11	18					0	0	1	0	0
NIPAL1	152519	broad.mit.edu	37	4	48037777	48037777	+	Missense_Mutation	SNP	C	C	T	rs139075175	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:48037777C>T	ENST00000295461.5	+	6	887	c.821C>T	c.(820-822)cCg>cTg	p.P274L		NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	274						integral to membrane				endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						TACAAACATCCGCTGGTCTTT	0.423000													23	38					0	0	1	0	0
XPC	7508	broad.mit.edu	37	3	14214486	14214486	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:14214486G>A	ENST00000285021.7	-	2	394	c.180C>T	c.(178-180)tgC>tgT	p.C60C	XPC_ENST00000449060.2_Silent_p.C60C	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	60	Glu-rich (acidic).				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CAGGATGACTGCAGCCTCTTT	0.448000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				7	15					0	0	1	0	0
SLC25A45	283130	broad.mit.edu	37	11	65144483	65144483	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65144483G>A	ENST00000417511.2	-	9	1412	c.278C>T	c.(277-279)gCc>gTc	p.A93V	SLC25A45_ENST00000377152.2_Missense_Mutation_p.A31V|SLC25A45_ENST00000526432.1_Missense_Mutation_p.A73V|SLC25A45_ENST00000534028.1_Missense_Mutation_p.A111V|SLC25A45_ENST00000398802.1_Missense_Mutation_p.A135V|SLC25A45_ENST00000360662.3_Missense_Mutation_p.A111V|SLC25A45_ENST00000294187.6_Missense_Mutation_p.A93V|SLC25A45_ENST00000527174.1_Missense_Mutation_p.A135V	NM_001278251.1	NP_001265180.1	Q8N413	S2545_HUMAN	solute carrier family 25, member 45	135					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	14						CCCTGGCTGGGCCCTTGGCTC	0.662000													5	30					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47697477	47697477	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:47697477G>A	ENST00000397708.1	-	6	2076	c.1822C>T	c.(1822-1824)Cgc>Tgc	p.R608C	MCM3AP_ENST00000291688.1_Missense_Mutation_p.R608C			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	608					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					TCAAGCAGGCGGTACTTCTCC	0.592000													40	11					0	0	1	0	0
CLIP2	7461	broad.mit.edu	37	7	73811444	73811444	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:73811444C>T	ENST00000223398.6	+	14	3088	c.2761C>T	c.(2761-2763)Cgt>Tgt	p.R921C	CLIP2_ENST00000395060.1_Missense_Mutation_p.R921C|CLIP2_ENST00000361545.5_Missense_Mutation_p.R886C	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	921						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						GGAGGCCAATCGTCACTCCCC	0.642000													9	27					0	0	1	0	0
ALG10B	144245	broad.mit.edu	37	12	38710823	38710823	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:38710823C>A	ENST00000308742.4	+	1	444	c.128C>A	c.(127-129)cCt>cAt	p.P43H	ALG10B_ENST00000551464.1_Missense_Mutation_p.P43H	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	43					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TTCCACCTGCCTCAGGCGCAG	0.637000													62	78					7.93275e-45	8.91933e-45	1	1	0
ADAM9	8754	broad.mit.edu	37	8	38874762	38874762	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:38874762G>A	ENST00000487273.2	+	6	513	c.435G>A	c.(433-435)gcG>gcA	p.A145A		NM_003816.2	NP_003807.1	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9	145					activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			TAGAGAATGCGAGTTATGGGA	0.373000													5	62					0	0	1	0	0
UBA7	7318	broad.mit.edu	37	3	49847305	49847305	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49847305C>T	ENST00000333486.3	-	15	2005	c.1847G>A	c.(1846-1848)cGg>cAg	p.R616Q		NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	616					ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AAACTCATGCCGGGCCCACTG	0.582000													29	67					0	0	1	0	0
SH3D19	152503	broad.mit.edu	37	4	152058907	152058907	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:152058907G>A	ENST00000409598.4	-	14	2731	c.1564C>T	c.(1564-1566)Cct>Tct	p.P522S	SH3D19_ENST00000427414.2_Missense_Mutation_p.P486S|SH3D19_ENST00000514152.1_Missense_Mutation_p.P522S|SH3D19_ENST00000409252.2_Missense_Mutation_p.P545S|SH3D19_ENST00000455740.1_Missense_Mutation_p.P522S|SH3D19_ENST00000304527.4_Missense_Mutation_p.P545S|SH3D19_ENST00000424281.1_Missense_Mutation_p.P486S			Q5HYK7	SH319_HUMAN	SH3 domain containing 19	545	SH3 2.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(1)|skin(3)|urinary_tract(1)	20	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				TAGTTGGCAGGAAATATGCCA	0.368000													14	39					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41125316	41125316	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41125316C>T	ENST00000308370.7	+	26	3333	c.3333C>T	c.(3331-3333)ggC>ggT	p.G1111G	LTBP4_ENST00000243562.9_Silent_p.G165G|LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000204005.9_Silent_p.G1074G|LTBP4_ENST00000396819.3_Silent_p.G1044G|LTBP4_ENST00000545697.1_Silent_p.G479G	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1112	Cys-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ATGTCGAAGGCTCCTTCCTCT	0.537000													23	41					0	0	1	0	0
ATP11C	286410	broad.mit.edu	37	X	138814672	138814672	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:138814672G>T	ENST00000370543.1	-	29	3408	c.3310C>A	c.(3310-3312)Ctc>Atc	p.L1104I	ATP11C_ENST00000361648.2_Intron|ATP11C_ENST00000460773.1_5'UTR|ATP11C_ENST00000370557.1_Intron|ATP11C_ENST00000327569.3_Intron			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	0					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					GAGGAAGGGAGGCGTTTCGTT	0.358000													6	1					0.000157383	0.000161063	1	1	0
TONSL	4796	broad.mit.edu	37	8	145667732	145667732	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145667732G>A	ENST00000409379.3	-	6	671	c.642C>T	c.(640-642)cgC>cgT	p.R214R		NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	214					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						GCTGGCCCGCGCGCCAGTGGA	0.642000													8	10					0	0	1	0	0
SLC22A17	51310	broad.mit.edu	37	14	23816920	23816920	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23816920C>T	ENST00000354772.3	-	8	1468	c.965G>A	c.(964-966)cGc>cAc	p.R322H	SLC22A17_ENST00000397267.1_Missense_Mutation_p.R322H|SLC22A17_ENST00000206544.8_Missense_Mutation_p.R322H|SLC22A17_ENST00000474057.1_5'UTR|SLC22A17_ENST00000397260.3_Missense_Mutation_p.R211H	NM_016609.3	NP_057693.3	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17	322					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GTAGCAGTGGCGAATGGCATG	0.622000													24	24					0	0	1	0	0
NGLY1	55768	broad.mit.edu	37	3	25820135	25820135	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:25820135G>A	ENST00000428257.1	-	2	283	c.176C>T	c.(175-177)aCa>aTa	p.T59I	NGLY1_ENST00000280700.5_Missense_Mutation_p.T59I|NGLY1_ENST00000422724.2_5'UTR|NGLY1_ENST00000417874.2_Missense_Mutation_p.T17I|NGLY1_ENST00000396649.3_Missense_Mutation_p.T59I	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	59	PUB.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						AGAAAAGGCTGTGTTTCCAAT	0.358000													44	50					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2428502	2428502	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:2428502C>T	ENST00000452833.1	-	20	2979	c.2971G>A	c.(2971-2973)Gca>Aca	p.A991T	TRPM5_ENST00000528453.1_Missense_Mutation_p.A989T|AC124057.5_ENST00000433035.1_RNA|TRPM5_ENST00000533060.1_Missense_Mutation_p.A989T|TRPM5_ENST00000155858.6_Missense_Mutation_p.A989T			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	989						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		AACATGTCTGCGTTGCCCTGC	0.652000													11	11					0	0	1	0	0
PFKM	5213	broad.mit.edu	37	12	48536609	48536609	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48536609G>A	ENST00000340802.6	+	20	2135	c.1911G>A	c.(1909-1911)cgG>cgA	p.R637R	PFKM_ENST00000547587.1_Silent_p.R566R|PFKM_ENST00000395233.2_Silent_p.R535R|PFKM_ENST00000359794.5_Silent_p.R566R|PFKM_ENST00000551804.1_Silent_p.R535R|PFKM_ENST00000312352.7_Silent_p.R566R	NM_001166686.1	NP_001160158.1	P08237	K6PF_HUMAN	phosphofructokinase, muscle	566					fructose 6-phosphate metabolic process|glycolysis|muscle cell homeostasis	6-phosphofructokinase complex|apical plasma membrane	6-phosphofructokinase activity|ATP binding|identical protein binding|kinase binding|metal ion binding|protein C-terminus binding			NS(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						CCAAGCGTCGGGTGTTTATCA	0.532000													9	74					0	0	1	0	0
EHD1	10938	broad.mit.edu	37	11	64627628	64627628	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64627628T>C	ENST00000320631.3	-	3	937	c.683A>G	c.(682-684)cAg>cGg	p.Q228R	EHD1_ENST00000359393.2_Missense_Mutation_p.Q228R	NM_006795.2	NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	228					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						CCGCATCAGCTGCTGCGTCTC	0.587000													20	20					0	0	1	0	0
M6PR	4074	broad.mit.edu	37	12	9095068	9095068	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:9095068C>A	ENST00000000412.3	-	6	1123	c.655G>T	c.(655-657)Gga>Tga	p.G219*		NM_002355.3	NP_002346.1	P20645	MPRD_HUMAN	mannose-6-phosphate receptor (cation dependent)	219					endosome to lysosome transport|receptor-mediated endocytosis	cell surface|endosome|integral to plasma membrane|lysosomal membrane	mannose binding|mannose transmembrane transporter activity|transmembrane receptor activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(1)	11		Hepatocellular(102;0.137)		BRCA - Breast invasive adenocarcinoma(232;0.0146)		TGCTCCATTCCTTTGGCTCCC	0.478000													24	46					1.85244e-09	1.96811e-09	1	1	0
SNX31	169166	broad.mit.edu	37	8	101629955	101629955	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:101629955T>C	ENST00000311812.2	-	5	475	c.325A>G	c.(325-327)Aca>Gca	p.T109A	SNX31_ENST00000428383.2_Missense_Mutation_p.T10A	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	109	PX.				cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			ATGTCAAATGTATTCTATAAG	0.388000													40	37					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1714291	1714291	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:1714291G>A	ENST00000313871.3	+	3	973	c.777G>A	c.(775-777)tcG>tcA	p.S259S	AKAP17A_ENST00000381261.3_Silent_p.S259S	NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	259					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						CTTTTGATTCGACCAAACACC	0.532000													49	96					0	0	1	0	0
FAM57B	83723	broad.mit.edu	37	16	30037072	30037072	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30037072A>G	ENST00000380495.4	-	4	1246	c.515T>C	c.(514-516)gTc>gCc	p.V172A	FAM57B_ENST00000564806.1_Missense_Mutation_p.V122A|FAM57B_ENST00000279389.4_Missense_Mutation_p.V122A	NM_031478.4	NP_113666.2	Q71RH2	FA57B_HUMAN	family with sequence similarity 57, member B	172	TLC.					endoplasmic reticulum|integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(1)	14						GCCAAGGCAGACGAAGGGCGT	0.597000													50	61					0	0	1	0	0
KLHL12	59349	broad.mit.edu	37	1	202880299	202880299	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:202880299G>A	ENST00000367261.3	-	5	818	c.600C>T	c.(598-600)gtC>gtT	p.V200V	KLHL12_ENST00000435533.3_Silent_p.V238V	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	200					Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			CCCAGTTGATGACAGCCTCAA	0.468000													65	113					0	0	1	0	0
PCDHB18	0	broad.mit.edu	37	5	140616030	140616030	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140616030C>T	ENST00000526308.1	+	0	2093					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						GAGCGCGACGCGGCCAAGCAC	0.701000													14	35					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3306561	3306561	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3306561C>T	ENST00000219596.1	-	1	66	c.27G>A	c.(25-27)ctG>ctA	p.L9L	MEFV_ENST00000339854.4_Silent_p.L9L|MEFV_ENST00000536379.1_Silent_p.L9L|MEFV_ENST00000541159.1_Silent_p.L9L	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	9	DAPIN.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	GGGTGGACAGCAGATGGTCAC	0.567000													13	10					0	0	1	0	0
GALNT18	374378	broad.mit.edu	37	11	11292756	11292756	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:11292756C>T	ENST00000227756.4	-	11	2170	c.1759G>A	c.(1759-1761)Gtg>Atg	p.V587M		NM_198516.2	NP_940918.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18																		TTCTGCAACACCAGCTGGAAG	0.627000													16	31					0	0	1	0	0
IREB2	3658	broad.mit.edu	37	15	78777262	78777262	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:78777262G>T	ENST00000258886.8	+	12	1722	c.1573_splice	c.e12+1	p.G525_splice		NM_004136.2	NP_004127.1	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	525							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		GCTTGCTGCAGGTGGGTTGTG	0.373000													7	91					0.0293803	0.0295506	1	1	0
LCT	3938	broad.mit.edu	37	2	136570440	136570440	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:136570440G>A	ENST00000264162.2	-	7	1804	c.1794C>T	c.(1792-1794)ggC>ggT	p.G598G		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	598	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCAGCACAATGCCCACGTGCC	0.567000													7	6					0	0	1	0	0
FBXW5	54461	broad.mit.edu	37	9	139835726	139835726	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139835726G>A	ENST00000325285.3	-	8	1513	c.1434C>T	c.(1432-1434)gaC>gaT	p.D478D	FBXW5_ENST00000483559.1_5'UTR	NM_018998.3	NP_061871.1	Q969U6	FBXW5_HUMAN	F-box and WD repeat domain containing 5	478							catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	12	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		CCCTGCTGACGTCCAGGAAGA	0.697000													9	4					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129864363	129864363	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:129864363G>A	ENST00000254667.3	+	11	1027	c.748G>A	c.(748-750)Gac>Aac	p.D250N	PTPRE_ENST00000306042.5_Missense_Mutation_p.D192N|PTPRE_ENST00000419012.2_Missense_Mutation_p.D250N|PTPRE_ENST00000430713.2_3'UTR	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	250	Tyrosine-protein phosphatase 1.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				GTACTGGCCCGACCAAGGCTG	0.517000													49	55					0	0	1	0	0
C1orf61	10485	broad.mit.edu	37	1	156376942	156376942	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156376942A>G	ENST00000368243.1	-	6	469	c.353T>C	c.(352-354)aTg>aCg	p.M118T		NM_006365.1	NP_006356.1	Q13536	CROC4_HUMAN	chromosome 1 open reading frame 61	118						nucleus				large_intestine(2)|lung(2)|skin(1)	5	Hepatocellular(266;0.158)					ttggttagacatggagaagga	0.468000													4	11					0	0	1	0	0
PCDHGA1	0	broad.mit.edu	37	5	140712130	140712130	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140712130C>T	ENST00000517417.1	+	1	1879	c.1879C>T	c.(1879-1881)Cgc>Tgc	p.R627C	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.R627C	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGAGGTGCGCACGGCGCG	0.697000													13	32					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179633626	179633626	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179633626G>A	ENST00000589042.1	-	38	9161	c.8937C>T	c.(8935-8937)aaC>aaT	p.N2979N	TTN_ENST00000342175.6_Silent_p.N2933N|TTN_ENST00000360870.5_Silent_p.N2979N|TTN_ENST00000591111.1_Silent_p.N2979N|TTN_ENST00000460472.2_Silent_p.N2933N|TTN_ENST00000342992.6_Silent_p.N2979N|TTN_ENST00000359218.5_Silent_p.N2933N|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2717	Ig-like 17.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.N2933N(3)|p.N2979N(2)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTTCAGCGTTGATGTCTT	0.368000													18	32					0	0	1	0	0
EFNB3	1949	broad.mit.edu	37	17	7611488	7611488	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7611488G>A	ENST00000226091.2	+	2	732	c.335G>A	c.(334-336)cGc>cAc	p.R112H		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	112					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				CTGGATCTCCGCTTCACCATC	0.587000													24	46					0	0	1	0	0
ILKAP	80895	broad.mit.edu	37	2	239082199	239082199	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:239082199C>T	ENST00000254654.3	-	10	1107	c.932G>A	c.(931-933)cGc>cAc	p.R311H		NM_030768.2	NP_110395.1	Q9H0C8	ILKAP_HUMAN	integrin-linked kinase-associated serine/threonine phosphatase	311	PP2C-like.					cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)		CAGCTGGCAGCGTCTGATGTC	0.542000													10	16					0	0	1	0	0
NRF1	4899	broad.mit.edu	37	7	129357154	129357154	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:129357154G>T	ENST00000393232.1	+	9	1278	c.1161G>T	c.(1159-1161)gaG>gaT	p.E387D	NRF1_ENST00000311967.2_Missense_Mutation_p.E387D|NRF1_ENST00000353868.4_Missense_Mutation_p.E321D|NRF1_ENST00000393231.3_Missense_Mutation_p.E387D|NRF1_ENST00000539636.1_Missense_Mutation_p.E226D|NRF1_ENST00000393230.2_Missense_Mutation_p.E387D|NRF1_ENST00000223190.4_Missense_Mutation_p.E387D	NM_005011.3	NP_005002.3	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	387	Required for transcriptional activation.				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	24						CGTTGGCAGAGGCCGCAGTGG	0.567000													7	19					0.00307968	0.00311927	1	1	0
CAPS	828	broad.mit.edu	37	19	5914990	5914990	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5914990G>A	ENST00000588776.1	+	4	2926	c.559G>A	c.(559-561)Gca>Aca	p.A187T	CAPS_ENST00000452990.2_Missense_Mutation_p.A101T|CAPS_ENST00000222125.5_Missense_Mutation_p.A101T			Q13938	CAYP1_HUMAN	calcyphosine	101					intracellular signal transduction	cytoplasm	calcium ion binding			cervix(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	4						CATCGCAGCTGCATTTGCCAA	0.682000													22	23					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142486189	142486189	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:142486189G>T	ENST00000430863.1	-	0	1584					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		AACACGCTGCGGAAGCAGGTG	0.617000													5	6					0.184627	0.185007	1	1	0
NUP37	79023	broad.mit.edu	37	12	102492967	102492967	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:102492967G>A	ENST00000552283.1	-	5	505	c.366C>T	c.(364-366)ggC>ggT	p.G122G	NUP37_ENST00000543021.1_5'UTR|NUP37_ENST00000251074.1_Silent_p.G122G			Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	122					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			endometrium(3)|large_intestine(3)|lung(10)|ovary(1)	17						AATCGGTATGGCCCTCTAAAA	0.373000													24	38					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38945986	38945986	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38945986G>A	ENST00000355481.4	+	14	1683	c.1552G>A	c.(1552-1554)Gtg>Atg	p.V518M	RYR1_ENST00000360985.3_Missense_Mutation_p.V518M|RYR1_ENST00000359596.3_Missense_Mutation_p.V518M	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	518					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GAAAGAGATTGTGAATCTTCT	0.542000													24	38					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100433475	100433475	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:100433475G>A	ENST00000279907.7	-	20	4386	c.4174C>T	c.(4174-4176)Caa>Taa	p.Q1392*	UHRF1BP1L_ENST00000545232.2_Nonsense_Mutation_p.Q1042*	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1392										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						ACACTGCGTTGTTTCTTCAGA	0.448000													22	40					0	0	1	0	0
SALL4	57167	broad.mit.edu	37	20	50407775	50407775	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:50407775C>T	ENST00000217086.4	-	2	1358	c.1247G>A	c.(1246-1248)gGt>gAt	p.G416D	SALL4_ENST00000395997.3_Intron|SALL4_ENST00000371539.3_Intron	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	416					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GAAGCGATGACCACAGACAGA	0.542000													25	34					0	0	1	0	0
MRPS10	55173	broad.mit.edu	37	6	42185562	42185562	+	Missense_Mutation	SNP	G	G	A	rs141744276	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:42185562G>A	ENST00000053468.3	-	1	41	c.26C>T	c.(25-27)gCt>gTt	p.A9V		NM_018141.3	NP_060611.2	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	9					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|lung(1)	2	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			CCGGCACACAGCACCGAACGC	0.612000													6	12					0	0	1	0	0
PERP	64065	broad.mit.edu	37	6	138413380	138413380	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:138413380T>C	ENST00000421351.3	-	3	551	c.381A>G	c.(379-381)gtA>gtG	p.V127V		NM_022121.4	NP_071404.2	Q96FX8	PERP_HUMAN	PERP, TP53 apoptosis effector	127					apoptosis|cell adhesion	desmosome|Golgi apparatus|integral to membrane|nucleus				breast(1)|cervix(1)|endometrium(1)|lung(1)|prostate(1)	5	Breast(32;0.0799)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000878)|OV - Ovarian serous cystadenocarcinoma(155;0.000997)		CGGGGTAAATTACCAGGGAGA	0.468000													4	22					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50530613	50530613	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:50530613G>A	ENST00000374144.3	+	3	311	c.23G>A	c.(22-24)tGc>tAc	p.C8Y	C10orf71_ENST00000323868.4_Missense_Mutation_p.C8Y			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	8										endometrium(1)	1						AATAAGAAGTGCACAGACGCG	0.542000													5	2					0	0	1	0	0
PAQR9	344838	broad.mit.edu	37	3	142681178	142681178	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:142681178C>T	ENST00000340634.3	-	1	1000	c.1001G>A	c.(1000-1002)cGc>cAc	p.R334H		NM_198504.2	NP_940906.1	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	334						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						GAGGAACTGGCGCAGGCCCTC	0.592000													31	51					0	0	1	0	0
IL20RB	53833	broad.mit.edu	37	3	136699336	136699336	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:136699336G>T	ENST00000329582.4	+	2	366	c.117G>T	c.(115-117)caG>caT	p.Q39H	IL20RB_ENST00000484501.1_Intron|IL20RB_ENST00000309741.5_5'UTR|IL20RB-AS1_ENST00000462176.2_RNA	NM_144717.3	NP_653318.2	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta	39	Fibronectin type-III 1.					integral to membrane	receptor activity			kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14						CTGCCCCTCAGAACCTCTCTG	0.512000													63	79					1.41401e-22	1.57312e-22	1	1	0
ZNF141	7700	broad.mit.edu	37	4	367133	367133	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:367133C>T	ENST00000240499.7	+	4	1056	c.907C>T	c.(907-909)Cga>Tga	p.R303*	ZNF141_ENST00000512994.1_Intron|ZNF141_ENST00000505939.1_Intron	NM_003441.2	NP_003432.1	Q15928	ZN141_HUMAN	zinc finger protein 141	303					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	18						CAAACATAAGCGAATTCATAC	0.378000													35	68					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179740882	179740882	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:179740882G>A	ENST00000253778.8	-	14	1525	c.1356C>T	c.(1354-1356)ggC>ggT	p.G452G		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	452	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	AGATGGAGCTGCCCACGGTGT	0.711000													8	8					0	0	1	0	0
KIAA1737	85457	broad.mit.edu	37	14	77576214	77576214	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:77576214G>A	ENST00000361786.2	+	3	513	c.196G>A	c.(196-198)Gcc>Acc	p.A66T	KIAA1737_ENST00000555437.1_Intron|KIAA1737_ENST00000555611.1_Missense_Mutation_p.A66T|RP11-463C8.4_ENST00000557752.1_Intron	NM_033426.2	NP_219494.2	Q9C0C6	K1737_HUMAN	KIAA1737	66										endometrium(2)|lung(4)|prostate(3)	9			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0284)		CATGCTGAGCGCCTTAGGCTG	0.547000													29	29					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43703711	43703711	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:43703711C>T	ENST00000372806.3	+	11	1453	c.1358C>T	c.(1357-1359)cCc>cTc	p.P453L	STK4_ENST00000372801.1_3'UTR|STK4_ENST00000499879.2_Missense_Mutation_p.P398L	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	453	SARAH.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				GCCCTGGACCCCATGATGGAG	0.517000													16	36					0	0	1	0	0
KHK	3795	broad.mit.edu	37	2	27315233	27315233	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27315233C>T	ENST00000260599.6	+	2	639	c.126C>T	c.(124-126)aaC>aaT	p.N42N	KHK_ENST00000260598.5_Silent_p.N42N|KHK_ENST00000490823.1_3'UTR	NM_000221.2	NP_000212.1	P50053	KHK_HUMAN	ketohexokinase (fructokinase)	42					fructose catabolic process	cytosol	ATP binding|ketohexokinase activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGGAGGCAACGCGTCCAACT	0.617000													30	43					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2944670	2944670	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:2944670C>T	ENST00000397461.1	+	11	1572	c.1188C>T	c.(1186-1188)aaC>aaT	p.N396N	CNTN4_ENST00000397459.2_Silent_p.N68N|CNTN4_ENST00000358480.3_Silent_p.N177N|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000448906.2_Silent_p.N68N|CNTN4_ENST00000418658.1_Silent_p.N396N|CNTN4_ENST00000427331.1_Silent_p.N396N	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	396	Ig-like C2-type 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TCTTTTCCAACGCAGAGCTTA	0.353000													8	22					0	0	1	0	0
BTN2A3P	0	broad.mit.edu	37	6	26423271	26423271	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:26423271C>T	ENST00000466808.2	+	0	190																											CATGGAGGTGCGGTGGTTCCA	0.547000													10	22					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166166848	166166848	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166166848T>C	ENST00000357398.3	+	7	1003	c.713T>C	c.(712-714)gTg>gCg	p.V238A	SCN2A_ENST00000375427.2_Missense_Mutation_p.V238A|SCN2A_ENST00000283256.6_Missense_Mutation_p.V238A|SCN2A_ENST00000375437.2_Missense_Mutation_p.V238A			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	238					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	AAGACCATTGTGGGGGCCCTG	0.423000													42	103					0	0	1	0	0
IL20RB	53833	broad.mit.edu	37	3	136714374	136714374	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:136714374C>T	ENST00000329582.4	+	6	1050	c.801C>T	c.(799-801)ccC>ccT	p.P267P	IL20RB_ENST00000309741.5_3'UTR	NM_144717.3	NP_653318.2	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta	267						integral to membrane	receptor activity			kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14						CCTGTTGCCCCGTGGTGGTCC	0.522000													89	128					0	0	1	0	0
SLC35G1	159371	broad.mit.edu	37	10	95660860	95660860	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:95660860G>A	ENST00000371408.3	+	3	769	c.708G>A	c.(706-708)tcG>tcA	p.S236S	SLC35G1_ENST00000427197.1_Silent_p.S237S			Q2M3R5	TMM20_HUMAN	solute carrier family 35, member G1	237	DUF6 2.					integral to membrane											TTGCTGCATCGACTCTAGTTA	0.428000													36	44					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424065	56424065	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:56424065G>A	ENST00000588751.1	-	5	1142	c.1118C>T	c.(1117-1119)gCc>gTc	p.A373V	NLRP13_ENST00000342929.3_Missense_Mutation_p.A373V			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	373	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CACTAATGAGGCCTTAAGATC	0.438000													45	109					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88761405	88761405	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:88761405C>T	ENST00000444431.1	+	0	2535				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										ATCTACTGAGCGTTTCAGTCA	0.368000													42	95					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115217476	115217476	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:115217476G>A	ENST00000369538.3	-	12	1831	c.1784C>T	c.(1783-1785)aCg>aTg	p.T595M	AMPD1_ENST00000520113.2_Missense_Mutation_p.T599M|AMPD1_ENST00000353928.6_Missense_Mutation_p.T566M	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	566					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	GAACAGAAACGTATTCATGCC	0.438000													12	26					0	0	1	0	0
ACN9	57001	broad.mit.edu	37	7	96810494	96810494	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:96810494T>C	ENST00000432641.2	+	2	1479	c.345T>C	c.(343-345)ttT>ttC	p.F115F	ACN9_ENST00000479853.1_3'UTR|ACN9_ENST00000360382.4_3'UTR	NM_020186.2	NP_064571.1	Q9NRP4	ACN9_HUMAN	ACN9 homolog (S. cerevisiae)	115					regulation of gluconeogenesis	mitochondrial intermembrane space				large_intestine(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(3)	10	all_cancers(62;2.54e-08)|all_epithelial(64;2.24e-08)|Esophageal squamous(72;0.00507)|all_lung(186;0.154)|Lung NSC(181;0.159)					ATAGGCAATTTAGTATTTCTG	0.358000													9	21					0	0	1	0	0
RP11-343N15.1	0	broad.mit.edu	37	1	121129791	121129791	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:121129791G>A	ENST00000437515.1	-	0	329																											TGAAGGACAGGCATTGAATAT	0.443000													7	5					0	0	1	0	0
ADARB2	105	broad.mit.edu	37	10	1279710	1279710	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:1279710A>G	ENST00000381312.1	-	6	1764	c.1439T>C	c.(1438-1440)cTc>cCc	p.L480P	ADARB2_ENST00000469464.1_5'UTR	NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	480	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GAGATGGAAGAGGATGTTCTC	0.547000													32	48					0	0	1	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138455972	138455972	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:138455972G>A	ENST00000310018.2	-	3	303	c.21C>T	c.(19-21)agC>agT	p.S7S	ATP6V0A4_ENST00000483139.1_5'UTR|ATP6V0A4_ENST00000393054.1_Silent_p.S7S|ATP6V0A4_ENST00000353492.4_Silent_p.S7S	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	7					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						ACATCTCCTCGCTTCGAAACA	0.438000													57	81					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156737869	156737869	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156737869G>A	ENST00000271526.4	+	1	578	c.306G>A	c.(304-306)gcG>gcA	p.A102A	PRCC_ENST00000491853.1_Intron|PRCC_ENST00000353233.3_Silent_p.A102A	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	102					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTGAAGCGGCGGGAGTTGGGG	0.726000			T	TFE3	papillary renal								3	7					0	0	1	0	0
DGKZ	8525	broad.mit.edu	37	11	46389291	46389291	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46389291G>T	ENST00000454345.1	+	4	1052	c.927G>T	c.(925-927)agG>agT	p.R309S	DGKZ_ENST00000395574.3_Missense_Mutation_p.R86S|DGKZ_ENST00000543978.1_Intron|DGKZ_ENST00000318201.8_Missense_Mutation_p.R120S|DGKZ_ENST00000343674.6_Missense_Mutation_p.R137S|DGKZ_ENST00000421244.2_Missense_Mutation_p.R120S|DGKZ_ENST00000528615.1_Intron|DGKZ_ENST00000527911.1_Missense_Mutation_p.R120S|DGKZ_ENST00000532868.2_Missense_Mutation_p.R124S|DGKZ_ENST00000456247.2_Missense_Mutation_p.R120S	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	309					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		GTGTAGCCAGGATGCTGGTGA	0.647000											OREG0020942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	12					0.000151284	0.000155038	1	1	0
AFG3L2	10939	broad.mit.edu	37	18	12351331	12351331	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:12351331C>A	ENST00000269143.3	-	11	1631	c.1400G>T	c.(1399-1401)gGg>gTg	p.G467V		NM_006796.2	NP_006787.2	Q9Y4W6	AFG32_HUMAN	AFG3-like AAA ATPase 2	467					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|prostate(3)|skin(1)|stomach(3)|urinary_tract(1)	27					Adenosine triphosphate(DB00171)	GTCGAAACGCCCCGGCCTAAG	0.458000													11	30					5.50884e-06	5.70893e-06	1	1	0
LIPE	3991	broad.mit.edu	37	19	42910406	42910406	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42910406G>A	ENST00000244289.4	-	7	2548	c.2272C>T	c.(2272-2274)Ctg>Ttg	p.L758L	LIPE-AS1_ENST00000599276.1_RNA|LIPE-AS1_ENST00000593491.2_RNA|LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000597203.1_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	758					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				GCAGGCTGCAGCATTGTGGCC	0.662000													8	19					0	0	1	0	0
SNX19	399979	broad.mit.edu	37	11	130775960	130775960	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:130775960C>T	ENST00000265909.4	-	7	2900	c.2331G>A	c.(2329-2331)atG>atA	p.M777I	SNX19_ENST00000533214.1_Missense_Mutation_p.M760I|SNX19_ENST00000530356.1_Missense_Mutation_p.M157I|SNX19_ENST00000545537.1_Missense_Mutation_p.M17I|SNX19_ENST00000528555.1_Missense_Mutation_p.M157I|SNX19_ENST00000539184.1_Missense_Mutation_p.M220I|SNX19_ENST00000533318.1_5'UTR|SNX19_ENST00000534726.1_Missense_Mutation_p.M17I	NM_014758.2	NP_055573.2	Q92543	SNX19_HUMAN	sorting nexin 19	777					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		TTGTTGGCTGCATTTCCAGTA	0.468000													22	34					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196636445	196636445	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:196636445C>A	ENST00000312428.6	-	61	11472	c.11372G>T	c.(11371-11373)cGg>cTg	p.R3791L	DNAH7_ENST00000409063.1_Missense_Mutation_p.R274L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3791					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTTATTGAACCGTCCCATCTC	0.403000													38	114					1.07121e-22	1.19187e-22	1	1	0
RP11-909M7.3	0	broad.mit.edu	37	14	101450261	101450261	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:101450261C>T	ENST00000554693.2	+	0	799				SNORD114-23_ENST00000363536.1_RNA																							ACAATGAATACGTGTCTGGAA	0.363000													39	56					0	0	1	0	0
DPF1	0	broad.mit.edu	37	19	38713072	38713072	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38713072C>T	ENST00000416611.1	-	3	349	c.226G>A	c.(226-228)Gcc>Acc	p.A76T	DPF1_ENST00000412732.1_Missense_Mutation_p.A20T|DPF1_ENST00000420980.2_Missense_Mutation_p.A102T|DPF1_ENST00000414789.1_Missense_Mutation_p.A20T|DPF1_ENST00000456296.1_Missense_Mutation_p.A76T|DPF1_ENST00000355526.4_Missense_Mutation_p.A102T			Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1	102					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding			large_intestine(1)|lung(4)|ovary(1)|skin(1)	7	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CAACAGCGGGCGGGGTACGTG	0.697000													38	63					0	0	1	0	0
UFSP2	55325	broad.mit.edu	37	4	186329445	186329445	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:186329445T>C	ENST00000264689.6	-	8	1092	c.976A>G	c.(976-978)Aca>Gca	p.T326A		NM_018359.3	NP_060829.2	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	326						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		TCTCTGTGTGTTGGAATGGAC	0.398000													14	68					0	0	1	0	0
MFSD6	54842	broad.mit.edu	37	2	191302098	191302098	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:191302098G>A	ENST00000392328.1	+	3	1667	c.1343G>A	c.(1342-1344)gGc>gAc	p.G448D	MFSD6_ENST00000281416.7_Missense_Mutation_p.G448D	NM_017694.3	NP_060164.3	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing 6	448					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						GTGCAGTATGGCTCAGTGCTG	0.498000													58	97					0	0	1	0	0
PPP4R1	9989	broad.mit.edu	37	18	9583125	9583125	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:9583125G>T	ENST00000400556.3	-	9	981	c.908C>A	c.(907-909)cCt>cAt	p.P303H	PPP4R1_ENST00000580583.1_Intron|PPP4R1_ENST00000400555.3_Missense_Mutation_p.P286H	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	303					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						CCAACGTGAAGGATCACTGAT	0.343000													12	28					3.27435e-08	3.44876e-08	1	1	0
PRUNE2	158471	broad.mit.edu	37	9	79323043	79323043	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:79323043T>C	ENST00000428286.1	-	8	4270	c.3070A>G	c.(3070-3072)Atc>Gtc	p.I1024V	PRUNE2_ENST00000376718.3_Missense_Mutation_p.I1383V			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1383					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						AGAGAGCTGATTTTGCCTGAT	0.463000													18	38					0	0	1	0	0
NXN	64359	broad.mit.edu	37	17	704251	704251	+	Missense_Mutation	SNP	C	C	T	rs147466128		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:704251C>T	ENST00000336868.3	-	8	1337	c.1246G>A	c.(1246-1248)Gcc>Acc	p.A416T	NXN_ENST00000538650.1_Missense_Mutation_p.A107T|NXN_ENST00000537628.2_Missense_Mutation_p.A167T|NXN_ENST00000575801.1_Missense_Mutation_p.A308T	NM_022463.4	NP_071908.2	Q6DKJ4	NXN_HUMAN	nucleoredoxin	416					cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		TCCACGATGGCGGGGGTGATC	0.572000													12	21					0	0	1	0	0
PPIL4	85313	broad.mit.edu	37	6	149826637	149826637	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:149826637G>A	ENST00000340881.2	-	3	862	c.329C>T	c.(328-330)gCa>gTa	p.A110V	PPIL4_ENST00000253329.2_Silent_p.S477S			Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 4	476	PPIase cyclophilin-type.				protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding			endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	13		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		TTGGACTTCTGCTTCGGTCTC	0.353000													23	41					0	0	1	0	0
POU2AF1	5450	broad.mit.edu	37	11	111225283	111225283	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:111225283C>T	ENST00000393067.3	-	5	988	c.474G>A	c.(472-474)acG>acA	p.T158T		NM_006235.2	NP_006226.2	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	158					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|kidney(2)|lung(2)	5		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		CCACTGCGGGCGTGGCGGAGC	0.642000			T	BCL6	NHL								3	0					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22179484	22179484	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:22179484G>A	ENST00000374695.3	-	51	6598	c.6519C>T	c.(6517-6519)tgC>tgT	p.C2173C	HSPG2_ENST00000430507.1_Silent_p.C119C	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2173	Ig-like C2-type 7.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGGGCACCACGCAGTTCAGAT	0.716000													21	24					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23225613	23225613	+	Silent	SNP	G	G	A	rs137863437		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:23225613G>A	ENST00000389131.3	-	2	621	c.252C>T	c.(250-252)tgC>tgT	p.C84C		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	84	SRCR 1.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		AGTCGTCATCGCACACGGTGC	0.647000													18	34					0	0	1	0	0
TBC1D31	93594	broad.mit.edu	37	8	124089435	124089435	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:124089435C>T	ENST00000287380.1	+	2	252	c.162C>T	c.(160-162)ggC>ggT	p.G54G	TBC1D31_ENST00000521676.1_5'UTR|TBC1D31_ENST00000327098.5_Silent_p.G54G|TBC1D31_ENST00000378080.2_5'UTR|TBC1D31_ENST00000522420.1_5'UTR|TBC1D31_ENST00000309336.3_Silent_p.G54G	NM_145647.3	NP_663622.2			TBC1 domain family, member 31																		ATGGCACAGGCGACTGCTTAA	0.358000													36	60					0	0	1	0	0
MSL1	339287	broad.mit.edu	37	17	38289322	38289322	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38289322C>T	ENST00000398532.3	+	6	1831	c.1516C>T	c.(1516-1518)Cgg>Tgg	p.R506W	MSL1_ENST00000579565.1_Missense_Mutation_p.R243W|MSL1_ENST00000578648.1_Missense_Mutation_p.R490W			Q68DK7	MSL1_HUMAN	male-specific lethal 1 homolog (Drosophila)	506					histone H4-K16 acetylation	MSL complex				endometrium(1)|kidney(2)|large_intestine(2)|lung(2)	7						GTTTTCGAAGCGGCATGCAAA	0.428000													9	5					0	0	1	0	0
MT1A	4489	broad.mit.edu	37	16	56672671	56672671	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:56672671C>T	ENST00000290705.8	+	1	94	c.21C>T	c.(19-21)tgC>tgT	p.C7C		NM_005946.2	NP_005937.2	P04731	MT1A_HUMAN	metallothionein 1A	7	Beta.					cytoplasm	cadmium ion binding|copper ion binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(1)	3						ACTGCTCCTGCGCCACTGGTA	0.542000													40	55					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80497209	80497209	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:80497209C>T	ENST00000265080.4	+	19	2921	c.2854C>T	c.(2854-2856)Cga>Tga	p.R952*		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	952					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity	p.R952*(1)		biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AGAAGTTTTGCGAGACCCAGA	0.403000													4	96					0	0	1	0	0
FAM124A	220108	broad.mit.edu	37	13	51855375	51855375	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:51855375G>A	ENST00000322475.8	+	4	1759	c.1624G>A	c.(1624-1626)Gag>Aag	p.E542K	FAM124A_ENST00000280057.6_Missense_Mutation_p.E578K	NM_001242312.1	NP_001229241.1	Q86V42	F124A_HUMAN	family with sequence similarity 124A	542										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|skin(1)	26		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		TAACGACATGGAGGAATTCTA	0.582000													10	15					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31022609	31022609	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31022609G>A	ENST00000375687.4	+	13	2518	c.2094G>A	c.(2092-2094)ccG>ccA	p.P698P	ASXL1_ENST00000306058.5_Silent_p.P693P	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	698					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						AACTACTGCCGCCTTATCCTC	0.587000			"""F, N, Mis"""		"""MDS, CMML"""								9	8					0	0	1	0	0
PIK3CD	5293	broad.mit.edu	37	1	9781512	9781512	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:9781512C>T	ENST00000536656.1	+	15	2102	c.1894C>T	c.(1894-1896)Ctg>Ttg	p.L632L	PIK3CD_ENST00000543390.1_Silent_p.L275L|PIK3CD_ENST00000361110.2_Silent_p.L632L|PIK3CD_ENST00000377346.4_Silent_p.L608L			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	608					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GGACGATGAGCTGTTCCAGTA	0.657000													10	15					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90437643	90437643	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:90437643G>T	ENST00000369393.3	-	37	5496	c.5381C>A	c.(5380-5382)cCt>cAt	p.P1794H	MDN1_ENST00000428876.1_Missense_Mutation_p.P1794H			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1794					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACCTTCAACAGGTAGATCTGC	0.488000													4	54					0.014758	0.0148771	1	1	0
FMN2	56776	broad.mit.edu	37	1	240371408	240371408	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:240371408C>T	ENST00000319653.9	+	5	3526	c.3296C>T	c.(3295-3297)cCg>cTg	p.P1099L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1099	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ATACCCCCTCCGCCCCCTCTA	0.731000													8	22					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81056320	81056320	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:81056320C>A	ENST00000334512.5	+	13	1895	c.1323C>A	c.(1321-1323)acC>acA	p.T441T	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	441	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			GGCCACTCACCTCCCCCAACT	0.632000													15	41					2.32078e-09	2.46314e-09	1	1	0
COX4I2	84701	broad.mit.edu	37	20	30227798	30227798	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:30227798C>T	ENST00000376075.3	+	3	220	c.145C>T	c.(145-147)Cca>Tca	p.P49S	COX4I2_ENST00000490030.1_3'UTR	NM_032609.2	NP_115998.2	Q96KJ9	COX42_HUMAN	cytochrome c oxidase subunit IV isoform 2 (lung)	49					cellular respiration		cytochrome-c oxidase activity			breast(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)	11	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.01e-05)|all cancers(5;9.46e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00121)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			CTACCCCATGCCAGAAGAGCC	0.617000													9	26					0	0	1	0	0
GADD45GIP1	90480	broad.mit.edu	37	19	13065212	13065212	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13065212G>A	ENST00000316939.1	-	2	502	c.479C>T	c.(478-480)gCc>gTc	p.A160V		NM_052850.2	NP_443082.2	Q8TAE8	G45IP_HUMAN	growth arrest and DNA-damage-inducible, gamma interacting protein 1	160					cell cycle|interspecies interaction between organisms	nucleus	protein binding			ovary(2)|prostate(1)|skin(1)	4						GAGCTCCTGGGCCTCAGCCTG	0.622000													28	42					0	0	1	0	0
APLF	200558	broad.mit.edu	37	2	68740263	68740263	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:68740263C>T	ENST00000303795.4	+	4	564	c.393C>T	c.(391-393)tcC>tcT	p.S131S		NM_173545.2	NP_775816.1	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	131					double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	25						CACCAAAATCCCCCGTGATTA	0.363000													27	61					0	0	1	0	0
GSG1	83445	broad.mit.edu	37	12	13240093	13240093	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:13240093C>T	ENST00000337630.6	-	5	698	c.631G>A	c.(631-633)Gcc>Acc	p.A211T	GSG1_ENST00000537302.1_Missense_Mutation_p.A183T|GSG1_ENST00000432710.2_Missense_Mutation_p.A224T|GSG1_ENST00000351606.6_Missense_Mutation_p.G288D|GSG1_ENST00000396310.2_Missense_Mutation_p.A180T|GSG1_ENST00000457134.2_Missense_Mutation_p.A160T|GSG1_ENST00000396302.3_Missense_Mutation_p.G252D|GSG1_ENST00000324458.8_Missense_Mutation_p.A247T	NM_153823.3	NP_722545.2	Q2KHT4	GSG1_HUMAN	germ cell associated 1	234						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		TACTAGAAGGCCCAGCCATAA	0.512000													40	53					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75151249	75151249	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:75151249G>A	ENST00000356357.4	-	4	666	c.151C>T	c.(151-153)Cgg>Tgg	p.R51W	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1									p.R51W(1)									TAATTTCCCCGCACGTAGTCA	0.557000													10	22					0	0	1	0	0
DENND4C	55667	broad.mit.edu	37	9	19358036	19358036	+	Nonsense_Mutation	SNP	C	C	T	rs143290383		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:19358036C>T	ENST00000307015.9	+	24	4354	c.2602C>T	c.(2602-2604)Cga>Tga	p.R868*	DENND4C_ENST00000380432.2_Nonsense_Mutation_p.R1395*|DENND4C_ENST00000434457.2_Nonsense_Mutation_p.R1680*|DENND4C_ENST00000540671.1_Nonsense_Mutation_p.R725*|DENND4C_ENST00000602925.1_Nonsense_Mutation_p.R1631*			Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1395						integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TTTATCAAAGCGAAATGTGTC	0.383000													16	33					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38357177	38357177	+	Missense_Mutation	SNP	G	G	A	rs114657493	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38357177G>A	ENST00000273173.4	+	8	1598	c.1507G>A	c.(1507-1509)Gct>Act	p.A503T	SLC22A14_ENST00000448498.1_Missense_Mutation_p.A503T	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	503						integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		CCTCTACACCGCTGAGCTCCT	0.572000													42	59					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20444037	20444037	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:20444037C>A	ENST00000305051.5	+	1	435	c.360C>A	c.(358-360)gcC>gcA	p.A120A		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTTTTGATGCCTGCCTGGCCC	0.433000													23	75					2.21704e-12	2.3975e-12	1	1	0
TNN	63923	broad.mit.edu	37	1	175105005	175105005	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:175105005C>T	ENST00000239462.4	+	16	3468	c.3355C>T	c.(3355-3357)Cag>Tag	p.Q1119*		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1119	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GAACACTGGGCAGCTGGATTT	0.522000													29	33					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26173714	26173714	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:26173714G>A	ENST00000335473.7	+	8	2284	c.2034G>A	c.(2032-2034)gtG>gtA	p.V678V	MYO18B_ENST00000407587.2_Silent_p.V678V|MYO18B_ENST00000536101.1_Silent_p.V678V	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	678	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AACACCTGGTGGGGATGGCAG	0.627000													13	45					0	0	1	0	0
HLA-DMB	3109	broad.mit.edu	37	6	32906527	32906527	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32906527G>A	ENST00000416244.2	-	2	465	c.271C>T	c.(271-273)Cgc>Tgc	p.R91C	HLA-DMB_ENST00000418107.2_Missense_Mutation_p.R91C|XXbac-BPG181M17.5_ENST00000429234.1_Missense_Mutation_p.R123C			P28068	DMB_HUMAN	major histocompatibility complex, class II, DM beta	91	Beta-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						AGCCCATTGCGCAAGCGCTGC	0.557000													24	39					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	883102	883102	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:883102C>T	ENST00000456758.2	+	8	777	c.777C>T	c.(775-777)caC>caT	p.H259H	SUN1_ENST00000452783.2_Intron|SUN1_ENST00000457378.2_Silent_p.H222H|SUN1_ENST00000425407.2_Silent_p.H151H|SUN1_ENST00000405266.1_Silent_p.H201H|SUN1_ENST00000389574.3_Silent_p.H151H|SUN1_ENST00000401592.1_Silent_p.H201H|SUN1_ENST00000403868.1_Silent_p.H201H			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	201	EMD-binding.|SYNE2-binding.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TCACGGCGCACCCCGCGGCCC	0.582000													17	123					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105161034	105161034	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:105161034C>A	ENST00000436393.2	+	23	3587	c.3346C>A	c.(3346-3348)Ctg>Atg	p.L1116M	RIMS2_ENST00000507740.1_Intron|RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000406091.3_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	544					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TATCGTTGGTCTGTCACGGAA	0.468000										HNSCC(12;0.0054)			18	25					2.37509e-13	2.57931e-13	1	1	0
IGFALS	3483	broad.mit.edu	37	16	1842413	1842413	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1842413A>G	ENST00000415638.3	-	2	199	c.120T>C	c.(118-120)tcT>tcC	p.S40S	IGFALS_ENST00000568221.1_Intron|IGFALS_ENST00000215539.3_Intron	NM_001146006.1|NM_004970.2	NP_001139478.1|NP_004961.1	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid labile subunit	0	LRRNT.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding			endometrium(2)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	8						CTGCGGGGGGAGAGGCTTGGG	0.721000													14	12					0	0	1	0	0
NDUFS2	4720	broad.mit.edu	37	1	161176272	161176272	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161176272G>A	ENST00000392179.4	+	3	517	c.278G>A	c.(277-279)gGt>gAt	p.G93D	NDUFS2_ENST00000476409.2_5'UTR|NDUFS2_ENST00000367993.3_Missense_Mutation_p.G93D	NM_001166159.1	NP_001159631.1	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	93					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	18	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	GCAGCGCATGGTGTCCTGCGA	0.512000													15	36					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82582879	82582879	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:82582879T>C	ENST00000423517.2	-	5	7727	c.7390A>G	c.(7390-7392)Acc>Gcc	p.T2464A	PCLO_ENST00000333891.8_Missense_Mutation_p.T2464A	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2395	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ACAGCTGTGGTCTCTAGAGTA	0.408000													12	11					0	0	1	0	0
OTUD7A	161725	broad.mit.edu	37	15	31851385	31851385	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:31851385G>A	ENST00000382902.1	-	3	429	c.337C>T	c.(337-339)Cgg>Tgg	p.R113W	OTUD7A_ENST00000307050.4_Missense_Mutation_p.R113W			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	113						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding	p.R113W(1)		endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CGGGAAAGCCGCTTTTCTGCA	0.557000													6	16					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125465071	125465071	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:125465071C>T	ENST00000308736.2	-	4	801	c.703G>A	c.(703-705)Gtc>Atc	p.V235I	DHX37_ENST00000544745.1_Missense_Mutation_p.V22I	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	235							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		GGGATGAAGACGGCGGGCTTA	0.647000													25	50					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28369237	28369237	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28369237G>A	ENST00000261609.7	-	85	13242	c.13134C>T	c.(13132-13134)ctC>ctT	p.L4378L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4378					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CAGAAGGCCCGAGTCCAGTTT	0.562000													29	38					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47221572	47221572	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:47221572C>A	ENST00000319190.5	+	7	1288	c.920C>A	c.(919-921)cCt>cAt	p.P307H	TTC7A_ENST00000409245.1_Missense_Mutation_p.P273H|TTC7A_ENST00000394850.2_Missense_Mutation_p.P307H|TTC7A_ENST00000263737.6_Intron|TTC7A_ENST00000461601.1_3'UTR	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	307							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CTGTCCCACCCTCTGCCTGAG	0.612000													26	79					9.86323e-18	1.08645e-17	1	1	0
ANKRD11	29123	broad.mit.edu	37	16	89350369	89350369	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:89350369G>A	ENST00000301030.4	-	9	3041	c.2581C>T	c.(2581-2583)Cca>Tca	p.P861S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P861S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	861	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCTGTCACTGGCGAGTCCCAG	0.542000													23	34					0	0	1	0	0
B4GALT6	9331	broad.mit.edu	37	18	29206246	29206246	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:29206246C>T	ENST00000306851.5	-	8	1297	c.1001_splice	c.e8+1	p.R334_splice	B4GALT6_ENST00000237019.7_Splice_Site_p.R295_splice|B4GALT6_ENST00000383131.3_Splice_Site_p.R295_splice	NM_004775.3	NP_004766.2	Q9UBX8	B4GT6_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6	334					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(6)|pancreas(1)	20			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			TTCAACTTACCGTCCTAAAAA	0.388000													10	23					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17007014	17007014	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17007014G>T	ENST00000443236.1	-	41	5571	c.5540C>A	c.(5539-5541)cCt>cAt	p.P1847H	CPAMD8_ENST00000597335.1_5'UTR	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1800						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						TTCAGGCTCAGGGTCTGAGTC	0.612000													17	32					0.006122	0.0061903	1	1	0
HERC3	8916	broad.mit.edu	37	4	89574198	89574198	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:89574198G>A	ENST00000402738.1	+	6	881	c.642G>A	c.(640-642)tgG>tgA	p.W214*	HERC3_ENST00000407637.1_Nonsense_Mutation_p.W214*|HERC3_ENST00000264345.3_Nonsense_Mutation_p.W214*	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	214					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TTTTTGGCTGGGGGATGAATA	0.507000													17	28					0	0	1	0	0
STYXL1	51657	broad.mit.edu	37	7	75630243	75630243	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:75630243C>A	ENST00000451157.1	-	8	944	c.775G>T	c.(775-777)Gcc>Tcc	p.A259S	STYXL1_ENST00000431581.1_Missense_Mutation_p.A259S|STYXL1_ENST00000360591.3_3'UTR|STYXL1_ENST00000359697.3_Missense_Mutation_p.A259S|STYXL1_ENST00000340062.5_Missense_Mutation_p.A163S|STYXL1_ENST00000248600.1_Missense_Mutation_p.A259S			Q9Y6J8	STYL1_HUMAN	serine/threonine/tyrosine interacting-like 1	259	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	10						ATGAGGTAGGCTATGATGGCG	0.567000													20	36					2.52088e-20	2.79422e-20	1	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117368258	117368258	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:117368258C>T	ENST00000160373.3	-	17	4031	c.3940G>A	c.(3940-3942)Gtc>Atc	p.V1314I		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1314										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGACGCCAGACGGACAGAGCC	0.572000													13	60					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110509272	110509272	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:110509272C>T	ENST00000378402.5	+	64	10556	c.10452C>T	c.(10450-10452)tgC>tgT	p.C3484C		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3484					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTGGACATGCTGGGATTATG	0.338000										HNSCC(38;0.096)			14	45					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133936475	133936475	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:133936475C>T	ENST00000361069.4	+	13	2345	c.2212C>T	c.(2212-2214)Cca>Tca	p.P738S	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	738	Laminin EGF-like 6.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		ACGCTGTTTGCCAGGTTTCTA	0.622000													13	27					0	0	1	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123210312	123210312	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:123210312C>T	ENST00000349780.4	-	22	3065	c.2886G>A	c.(2884-2886)acG>acA	p.T962T	CDK5RAP2_ENST00000360190.4_Silent_p.T962T|CDK5RAP2_ENST00000359309.3_Silent_p.T962T|CDK5RAP2_ENST00000360822.3_Silent_p.T930T	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	962	Interaction with MAPRE1.				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						TCTGCAGCTGCGTCACCACCT	0.483000													9	72					0	0	1	0	0
LDLRAD4	753	broad.mit.edu	37	18	13645549	13645549	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:13645549C>T	ENST00000361205.4	+	7	1482	c.814C>T	c.(814-816)Cgc>Tgc	p.R272C	LDLRAD4_ENST00000399848.3_Missense_Mutation_p.R254C|LDLRAD4_ENST00000586765.1_Missense_Mutation_p.R217C|RP11-701H16.4_ENST00000588397.1_RNA|LDLRAD4_ENST00000585931.1_Missense_Mutation_p.R195C|LDLRAD4_ENST00000587757.1_Missense_Mutation_p.R235C|LDLRAD4_ENST00000592991.1_Missense_Mutation_p.R174C|LDLRAD4_ENST00000359446.5_Missense_Mutation_p.R272C	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		CCATCACCAGCGCAGCAACGC	0.582000													21	29					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104678884	104678884	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:104678884G>A	ENST00000369878.3	+	1	771	c.647G>A	c.(646-648)gGt>gAt	p.G216D	CNNM2_ENST00000457502.2_5'UTR|CNNM2_ENST00000369875.3_Missense_Mutation_p.G216D|CNNM2_ENST00000433628.2_Missense_Mutation_p.G216D	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	216					ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GGGGGCAAGGGTGGCTCGGGG	0.697000													12	15					0	0	1	0	0
PCDHA8	0	broad.mit.edu	37	5	140222014	140222014	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140222014G>A	ENST00000531613.1	+	1	1108	c.1108G>A	c.(1108-1110)Gcc>Acc	p.A370T	PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.A370T|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018911.2	NP_061734.1												p.A370T(2)		NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACTGTCATCGCCCTAATTAG	0.488000													46	62					0	0	1	0	0
ACVR1B	91	broad.mit.edu	37	12	52385742	52385742	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:52385742C>T	ENST00000257963.4	+	8	1434	c.1357C>T	c.(1357-1359)Cgt>Tgt	p.R453C	ACVR1B_ENST00000542485.1_Missense_Mutation_p.R401C|ACVR1B_ENST00000541224.1_Missense_Mutation_p.R494C|ACVR1B_ENST00000426655.2_Missense_Mutation_p.R453C|ACVR1B_ENST00000563121.1_3'UTR	NM_004302.4|NM_020328.3	NP_004293.1|NP_064733.3	P36896	ACV1B_HUMAN	activin A receptor, type IB	453	Protein kinase.				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			breast(5)|endometrium(4)|kidney(5)|large_intestine(12)|lung(10)|ovary(1)|pancreas(6)|prostate(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	TCAGAAGCTGCGTCCCAACAT	0.498000													36	45					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232564227	232564227	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:232564227A>G	ENST00000366630.1	-	16	4698	c.4340T>C	c.(4339-4341)gTt>gCt	p.V1447A	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.V1447A|SIPA1L2_ENST00000308942.4_Missense_Mutation_p.V521A			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1447					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTTAGACAGAACATGTTGAGT	0.453000													33	44					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19762591	19762591	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19762591C>A	ENST00000357324.6	-	17	2268	c.2242G>T	c.(2242-2244)Gga>Tga	p.G748*	ATP13A1_ENST00000291503.5_Nonsense_Mutation_p.G630*	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	748					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGGTTGTCTCCCGTGATCATG	0.597000													7	15					0.000157383	0.000161063	1	1	0
POMGNT1	55624	broad.mit.edu	37	1	46661564	46661564	+	Silent	SNP	C	C	T	rs146121135	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:46661564C>T	ENST00000396420.3	-	6	1089	c.453G>A	c.(451-453)acG>acA	p.T151T	POMGNT1_ENST00000535522.1_Silent_p.T129T|POMGNT1_ENST00000371984.3_Silent_p.T151T|POMGNT1_ENST00000371986.3_Silent_p.T151T|POMGNT1_ENST00000371992.1_Silent_p.T151T			Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	151					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					GAGGTGAGTACGTGTCAAACA	0.547000													4	26					0	0	1	0	0
RXRG	6258	broad.mit.edu	37	1	165386316	165386316	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:165386316C>T	ENST00000359842.5	-	4	886	c.584G>A	c.(583-585)cGc>cAc	p.R195H	RXRG_ENST00000470566.1_5'UTR	NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	195					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CTTCTGATAGCGACAGTACTG	0.507000													21	31					0	0	1	0	0
STX8	9482	broad.mit.edu	37	17	9395227	9395227	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:9395227C>T	ENST00000306357.3	-	6	887	c.460G>A	c.(460-462)Ggc>Agc	p.G154S	STX8_ENST00000574431.1_Missense_Mutation_p.G43S	NM_004853.2	NP_004844.1	Q9UNK0	STX8_HUMAN	syntaxin 8	154	t-SNARE coiled-coil homology.				transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(1)	12						GCATCAAGGCCTGCGTCCTGT	0.363000													21	77					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618377	77618377	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:77618377G>T	ENST00000521891.2	+	2	2502	c.2054G>T	c.(2053-2055)aGg>aTg	p.R685M	ZFHX4_ENST00000518282.1_Missense_Mutation_p.R685M|ZFHX4_ENST00000455469.2_Missense_Mutation_p.R685M|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Missense_Mutation_p.R685M	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	685						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCTCACCCCAGGCTTGCCCGG	0.502000										HNSCC(33;0.089)			11	16					0.00829132	0.00837884	1	1	0
ASUN	55726	broad.mit.edu	37	12	27081709	27081709	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:27081709G>A	ENST00000261191.7	-	4	966	c.430C>T	c.(430-432)Cgt>Tgt	p.R144C	ASUN_ENST00000539625.1_Missense_Mutation_p.R43C	NM_018164.2	NP_060634.2	Q9NVM9	M89BB_HUMAN	asunder spermatogenesis regulator	144					cell division|mitosis|regulation of mitotic cell cycle		protein binding										AGTAGAGTACGAGCCTCATGT	0.423000													30	48					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69345205	69345205	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:69345205G>A	ENST00000394419.4	-	20	2579	c.2397C>T	c.(2395-2397)cgC>cgT	p.R799R	ACTN1_ENST00000438964.2_Silent_p.R772R|ACTN1_ENST00000193403.6_Intron|ACTN1_ENST00000538545.2_Silent_p.R772R|ACTN1_ENST00000376839.3_Silent_p.R707R	NM_001130004.1	NP_001123476.1	P12814	ACTN1_HUMAN	actinin, alpha 1	787	EF-hand 2.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TCAGGCAGGCGCGGAAATCAT	0.602000													12	48					0	0	1	0	0
SOGA1	140710	broad.mit.edu	37	20	35443659	35443659	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:35443659C>T	ENST00000237536.4	-	5	2527	c.2186G>A	c.(2185-2187)cGg>cAg	p.R729Q	SOGA1_ENST00000456801.2_Missense_Mutation_p.R332Q|SOGA1_ENST00000279034.5_Missense_Mutation_p.R491Q|SOGA1_ENST00000357779.3_Missense_Mutation_p.R491Q	NM_080627.2	NP_542194.2	O94964	K0889_HUMAN	suppressor of glucose, autophagy associated 1	491										endometrium(5)|kidney(1)|lung(21)|urinary_tract(1)	28						ATCTGCCTTCCGCGTGAAGGC	0.622000													29	33					0	0	1	0	0
PRKAG1	5571	broad.mit.edu	37	12	49397614	49397614	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49397614G>A	ENST00000548065.1	-	9	1085	c.629C>T	c.(628-630)aCc>aTc	p.T210I	PRKAG1_ENST00000547306.1_Missense_Mutation_p.T159I|PRKAG1_ENST00000316299.5_Missense_Mutation_p.T219I|RP11-386G11.5_ENST00000552284.1_RNA|RP11-386G11.5_ENST00000547395.1_RNA|RP11-386G11.5_ENST00000552933.1_RNA|PRKAG1_ENST00000395170.3_Missense_Mutation_p.T126I|PRKAG1_ENST00000552212.1_Missense_Mutation_p.T178I|RP11-386G11.5_ENST00000547866.1_RNA			P54619	AAKG1_HUMAN	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	210	CBS 3.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glycolysis|spermatogenesis	cytosol	cAMP-dependent protein kinase activity|cAMP-dependent protein kinase regulator activity|protein kinase binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	9						GACGGGGGTGGTAGTGCGAAC	0.522000													42	69					0	0	1	0	0
SLC38A10	124565	broad.mit.edu	37	17	79226449	79226449	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79226449G>A	ENST00000374759.3	-	13	1874	c.1491C>T	c.(1489-1491)caC>caT	p.H497H	SLC38A10_ENST00000288439.5_Silent_p.H497H	NM_001037984.1	NP_001033073.1	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10	497					amino acid transport|sodium ion transport	integral to membrane				NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CAGGAGGCTCGTGGCGGTGGG	0.622000													26	24					0	0	1	0	0
GPR119	139760	broad.mit.edu	37	X	129519098	129519098	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:129519098C>T	ENST00000276218.2	-	1	413	c.324G>A	c.(322-324)aaG>aaA	p.K108K		NM_178471.2	NP_848566.1	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	108						integral to membrane|plasma membrane	lipid binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(3)|prostate(1)	11						GGAAGGGCTGCTTGATGGCAA	0.577000													41	9					0	0	1	0	0
SNX24	28966	broad.mit.edu	37	5	122272467	122272467	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:122272467T>C	ENST00000261369.4	+	2	284	c.99T>C	c.(97-99)caT>caC	p.H33H	SNX24_ENST00000511211.1_3'UTR|SNX24_ENST00000513881.1_Silent_p.H33H|SNX24_ENST00000395451.4_Silent_p.H66H|SNX24_ENST00000506996.1_Silent_p.H33H	NM_014035.2	NP_054754.1	Q9Y343	SNX24_HUMAN	sorting nexin 24	33	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			lung(5)	5		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		GAAGAAAACATTTTGTTGAAA	0.303000													17	39					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31305303	31305303	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:31305303A>C	ENST00000265071.2	+	7	1287	c.1022A>C	c.(1021-1023)aAa>aCa	p.K341T	CDH6_ENST00000514738.1_Missense_Mutation_p.K286T	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	341	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GAAAAGAAGAAAGTGTATACC	0.438000													32	23					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479680	4479680	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:4479680G>A	ENST00000237837.1	-	3	730	c.585C>T	c.(583-585)ccC>ccT	p.P195P		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	195			P -> S (in dbSNP:rs13312793).		cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			TCCGGGCCCGGGGCTTCAGCA	0.682000													11	20					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33596410	33596410	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:33596410C>T	ENST00000321505.4	+	9	3682	c.3502C>T	c.(3502-3504)Caa>Taa	p.Q1168*	KIAA1549L_ENST00000389726.3_Nonsense_Mutation_p.Q1174*|KIAA1549L_ENST00000265654.5_Nonsense_Mutation_p.Q1174*					KIAA1549-like																		TGTCCTTCTGCAAGCTGACCG	0.438000													38	62					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769229	31769229	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:31769229C>T	ENST00000240587.4	-	2	1797	c.1470G>A	c.(1468-1470)aaG>aaA	p.K490K		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	490					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					CTTCGCCAGGCTTGTCTTTTT	0.468000													66	129					0	0	1	0	0
LPPR5	0	broad.mit.edu	37	1	99470129	99470129	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:99470129C>T	ENST00000370188.3	-	1	459	c.99G>A	c.(97-99)acG>acA	p.T33T	LPPR5_ENST00000263177.4_Silent_p.T33T|RP5-896L10.1_ENST00000425113.1_RNA	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		33						integral to membrane	hydrolase activity										TGAACGTGTCCGTATACTCGA	0.642000													23	38					0	0	1	0	0
VAX1	11023	broad.mit.edu	37	10	118891815	118891815	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118891815T>C	ENST00000277905.2	-	4	712		c.e4-2			NM_199131.2	NP_954582.1	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1							nucleus	sequence-specific DNA binding			endometrium(1)|large_intestine(1)|lung(8)|ovary(2)	12				all cancers(201;0.0108)		TTTTTTATCCTTCAAATATAA	0.393000													18	18					0	0	1	0	0
TAC1	6863	broad.mit.edu	37	7	97363108	97363108	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:97363108G>A	ENST00000319273.5	+	3	494	c.197G>A	c.(196-198)gGa>gAa	p.G66E	TAC1_ENST00000350485.4_Missense_Mutation_p.G66E|TAC1_ENST00000346867.4_Missense_Mutation_p.G66E	NM_003182.2	NP_003173.1	P20366	TKN1_HUMAN	tachykinin, precursor 1	66					detection of abiotic stimulus|elevation of cytosolic calcium ion concentration|insemination|neuropeptide signaling pathway|synaptic transmission|tachykinin receptor signaling pathway	extracellular space				large_intestine(4)|lung(6)|urinary_tract(1)	11	all_cancers(62;3.95e-09)|all_epithelial(64;1.1e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0358)|all_lung(186;0.0384)				Bacitracin(DB00626)	CAGTTCTTTGGATTAATGGGC	0.587000													35	60					0	0	1	0	0
KIAA1257	57501	broad.mit.edu	37	3	128712142	128712142	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:128712142C>T	ENST00000265068.5	-	2	173	c.6G>A	c.(4-6)tcG>tcA	p.S2S	KIAA1257_ENST00000510149.1_Intron|KIAA1257_ENST00000511438.1_Silent_p.S2S	NM_020741.2	NP_065792.1	Q9ULG3	K1257_HUMAN	KIAA1257	2										breast(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(2)	14						AGGCATGTAGCGACATGCTGC	0.617000													4	11					0	0	1	0	0
ZACN	353174	broad.mit.edu	37	17	74077421	74077421	+	Missense_Mutation	SNP	G	G	A	rs143316623	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74077421G>A	ENST00000334586.5	+	6	690	c.607G>A	c.(607-609)Gta>Ata	p.V203I	EXOC7_ENST00000332065.5_3'UTR|EXOC7_ENST00000591724.1_Intron|EXOC7_ENST00000607838.1_3'UTR|EXOC7_ENST00000589210.1_3'UTR	NM_180990.3	NP_851321.2	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	203					response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	11						GAGGGAATACGTAGTTTATGA	0.562000													46	81					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91630560	91630560	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:91630560G>T	ENST00000359028.2	+	9	1590	c.1365G>T	c.(1363-1365)caG>caT	p.Q455H	AKAP9_ENST00000358100.2_Missense_Mutation_p.Q455H|AKAP9_ENST00000356239.3_Missense_Mutation_p.Q443H			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	455	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TGTATGGGCAGCAGATAGTGC	0.408000			T	BRAF	papillary thyroid								14	67					1.3612e-06	1.41782e-06	1	1	0
MTUS2	23281	broad.mit.edu	37	13	29598970	29598970	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:29598970C>T	ENST00000431530.3	+	1	223	c.165C>T	c.(163-165)agC>agT	p.S55S		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	45						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TGGAGGTCAGCTCCTCTCATG	0.418000													8	21					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151921189	151921189	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:151921189G>A	ENST00000355193.2	-	20	3452	c.3234C>T	c.(3232-3234)tgC>tgT	p.C1078C	KMT2C_ENST00000262189.6_Silent_p.C1078C					lysine (K)-specific methyltransferase 2C																		CACAAGGAGCGCACTGTGTGT	0.438000													8	28					0	0	1	0	0
SCN1B	6324	broad.mit.edu	37	19	35524561	35524561	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35524561C>T	ENST00000262631.5	+	3	503	c.366C>T	c.(364-366)caC>caT	p.H122H	SCN1B_ENST00000415950.3_Silent_p.H122H|SCN1B_ENST00000596348.1_3'UTR|SCN1B_ENST00000595652.1_Intron	NM_001037.4	NP_001028.1	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta subunit	122	Ig-like C2-type.				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	11	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ACGAGTGCCACGTCTACCGCC	0.552000													27	62					0	0	1	0	0
FAM86DP	0	broad.mit.edu	37	3	75471166	75471166	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:75471166C>T	ENST00000459803.1	-	0	1975					NR_024241.1																						TTTGCAGATGCTTTTCTCAAA	0.547000													13	16					0	0	1	0	0
POLR1C	9533	broad.mit.edu	37	6	43487456	43487456	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43487456G>A	ENST00000372389.3	+	4	350	c.262G>A	c.(262-264)Gct>Act	p.A88T	POLR1C_ENST00000372344.2_Missense_Mutation_p.A88T|POLR1C_ENST00000304004.3_Missense_Mutation_p.A88T|RP3-337H4.9_ENST00000607571.1_RNA	NM_203290.2	NP_976035.1	O15160	RPAC1_HUMAN	polymerase (RNA) I polypeptide C, 30kDa	88					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity			kidney(1)|large_intestine(2)|lung(1)|prostate(1)	5	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GCCAACTATGGCTGTGGAGAA	0.507000													29	45					0	0	1	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43692277	43692277	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:43692277G>A	ENST00000564079.1	+	14	1694	c.1454G>A	c.(1453-1455)cGc>cAc	p.R485H	TUBGCP4_ENST00000399460.3_3'UTR|TUBGCP4_ENST00000260383.7_Missense_Mutation_p.R486H	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	486					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		CTGAGTGTGCGCCGGGTGCAA	0.483000													4	21					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29663474	29663474	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:29663474A>G	ENST00000358273.4	+	41	6513	c.6130A>G	c.(6130-6132)Aaa>Gaa	p.K2044E	NF1_ENST00000356175.3_Missense_Mutation_p.K2023E|NF1_ENST00000581113.2_3'UTR	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2044					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGGAAATGTGAAATTGGTTTC	0.368000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			7	72					0	0	1	0	0
USH1G	124590	broad.mit.edu	37	17	72916331	72916331	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72916331C>T	ENST00000319642.1	-	2	782	c.600G>A	c.(598-600)ccG>ccA	p.P200P		NM_173477.2	NP_775748.2	Q495M9	USH1G_HUMAN	Usher syndrome 1G (autosomal recessive)	200					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton			HN1/USH1G(2)	endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(3)	14	all_lung(278;0.172)|Lung NSC(278;0.207)					CCTGAGAGTACGGCAGGTGGC	0.677000													25	20					0	0	1	0	0
WFS1	7466	broad.mit.edu	37	4	6303575	6303575	+	Missense_Mutation	SNP	C	C	T	rs112967046		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:6303575C>T	ENST00000226760.1	+	8	2223	c.2053C>T	c.(2053-2055)Cgc>Tgc	p.R685C	WFS1_ENST00000503569.1_Missense_Mutation_p.R685C	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	685					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		CAACATGGCGCGCACCCAGAT	0.637000													10	25					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113192566	113192566	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:113192566G>A	ENST00000401783.2	-	33	5854	c.5518C>T	c.(5518-5520)Cca>Tca	p.P1840S	SVEP1_ENST00000374469.1_Missense_Mutation_p.P1817S	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1840	Sushi 7.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TTACAATATGGTATTAGATGA	0.373000													3	7					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85609385	85609385	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:85609385C>T	ENST00000322366.6	-	61	9753	c.9346G>A	c.(9346-9348)Gcc>Acc	p.A3116T	WDFY3_ENST00000295888.4_Missense_Mutation_p.A3133T			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3133						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GATGCTGTGGCGCAGGTGACG	0.468000													8	27					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20721257	20721257	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:20721257C>T	ENST00000404938.2	+	15	2489	c.1837C>T	c.(1837-1839)Cga>Tga	p.R613*	ABCB5_ENST00000258738.6_Nonsense_Mutation_p.R168*	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	168	ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						AATGGCAAAACGAGGTCTATA	0.418000													32	39					0	0	1	0	0
LINC00477	0	broad.mit.edu	37	12	24737079	24737079	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:24737079C>T	ENST00000483544.1	-	0	23					NR_029451.2																						AGACCAGGGGCGAAAGGCCTT	0.542000													17	21					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79296193	79296193	+	Silent	SNP	G	G	A	rs111385391	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:79296193G>A	ENST00000419573.3	-	16	2722	c.2448C>T	c.(2446-2448)ggC>ggT	p.G816G	RASGRF1_ENST00000558480.2_Silent_p.G800G|RASGRF1_ENST00000394745.3_Silent_p.G32G|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	818					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GGGTCGTATCGCCCTCATCTG	0.612000													6	25					0	0	1	0	0
ADH7	131	broad.mit.edu	37	4	100334311	100334311	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:100334311C>T	ENST00000437033.2	-	9	1622	c.1119G>A	c.(1117-1119)acG>acA	p.T373T	ADH7_ENST00000482593.1_Silent_p.T316T|ADH7_ENST00000209665.4_Silent_p.T385T|ADH7_ENST00000476959.1_Silent_p.T393T			P40394	ADH7_HUMAN	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	385					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)	19				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	GATCTCAAAACGTCAGGACCG	0.378000													25	76					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8501014	8501014	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:8501014G>A	ENST00000381196.4	-	21	2411	c.1868C>T	c.(1867-1869)tCc>tTc	p.S623F	PTPRD_ENST00000356435.5_Missense_Mutation_p.S623F|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.S623F|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000360074.4_Missense_Mutation_p.S610F|PTPRD_ENST00000358503.5_Missense_Mutation_p.S610F|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	623	Fibronectin type-III 4.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.S623F(1)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AATACTAGTGGAACTTGGGCT	0.443000										TSP Lung(15;0.13)			5	37					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16902810	16902810	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16902810C>T	ENST00000430580.2	-	19	2958	c.2071G>A	c.(2071-2073)Gct>Act	p.A691T	NBPF1_ENST00000287968.8_Missense_Mutation_p.A56T|NBPF1_ENST00000432949.1_Missense_Mutation_p.A149T	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	691						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CACCCCTCAGCCAGCTGTTCT	0.577000													43	813					0	0	1	0	0
SLC7A11	23657	broad.mit.edu	37	4	139106350	139106350	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:139106350G>A	ENST00000280612.5	-	7	1119	c.840C>T	c.(838-840)ggC>ggT	p.G280G		NM_014331.3	NP_055146.1	Q9UPY5	XCT_HUMAN	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	280					blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)	18	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	TCAGCACATAGCCAATGGTGA	0.423000													41	83					0	0	1	0	0
ADCK5	203054	broad.mit.edu	37	8	145616626	145616626	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145616626G>A	ENST00000308860.6	+	7	794	c.750G>A	c.(748-750)cgG>cgA	p.R250R	ADCK5_ENST00000526231.2_3'UTR	NM_174922.3	NP_777582.3	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	250	Protein kinase.					integral to membrane	protein serine/threonine kinase activity			endometrium(1)|lung(2)|prostate(2)|skin(1)|stomach(2)	8	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			TCCTGCTGCGGCTCGTTGAGG	0.637000													5	12					0	0	1	0	0
MVP	9961	broad.mit.edu	37	16	29848061	29848061	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:29848061G>A	ENST00000357402.5	+	7	829	c.691G>A	c.(691-693)Gct>Act	p.A231T	MVP_ENST00000395353.1_Missense_Mutation_p.A231T|MVP_ENST00000452209.2_Missense_Mutation_p.G45D	NM_005115.4|NM_017458.3	NP_005106.2|NP_059447.2	Q14764	MVP_HUMAN	major vault protein	231					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(7)|ovary(2)|skin(3)|soft_tissue(1)|stomach(1)	27						GCACCTCCGGGCTCGGCGGAA	0.617000													7	14					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35984805	35984805	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:35984805G>A	ENST00000297866.5	+	9	1600	c.1534G>A	c.(1534-1536)Gta>Ata	p.V512I		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	512										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TTTCCATCACGTATATTTAGC	0.383000													34	6					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85769338	85769338	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:85769338G>A	ENST00000373131.1	+	2	708	c.545G>A	c.(544-546)cGc>cAc	p.R182H	DACH2_ENST00000508860.1_Missense_Mutation_p.R28H|DACH2_ENST00000510272.1_5'UTR|DACH2_ENST00000373125.4_Missense_Mutation_p.R195H	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding	p.R182H(2)|p.R195H(2)		breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						GAAAATGCCCGCCTTCTGACC	0.468000													10	6					0	0	1	0	0
GPR107	0	broad.mit.edu	37	9	132890973	132890973	+	Missense_Mutation	SNP	C	C	T	rs145325808	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:132890973C>T	ENST00000372406.1	+	19	2146	c.1639C>T	c.(1639-1641)Cgt>Tgt	p.R547C	GPR107_ENST00000347136.6_Missense_Mutation_p.R499C|GPR107_ENST00000372410.3_Missense_Mutation_p.R518C	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	547						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				GTATAAATTCCGTCCGGCTTC	0.443000													15	130					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361411	70361411	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:70361411C>T	ENST00000305107.6	-	1	215	c.169G>A	c.(169-171)Gca>Aca	p.A57T	UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000512583.1_Missense_Mutation_p.A57T|UGT2B4_ENST00000381096.3_Intron	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	57					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						GCTGAAGATGCCAATACAGTC	0.408000													29	53					0	0	1	0	0
GRTP1	79774	broad.mit.edu	37	13	114009752	114009752	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:114009752G>A	ENST00000375430.4	-	3	272	c.226C>T	c.(226-228)Cgc>Tgc	p.R76C	GRTP1-AS1_ENST00000419199.1_RNA|GRTP1-AS1_ENST00000423246.1_RNA|GRTP1_ENST00000375431.4_Missense_Mutation_p.R76C			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	76	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			ATCCAGACGCGGGCACGGTGC	0.662000													10	16					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52426962	52426962	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52426962C>T	ENST00000420323.2	+	65	10656	c.10395C>T	c.(10393-10395)aaC>aaT	p.N3465N		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3530	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACCTGGCCAACGTGGACCCCA	0.582000													14	106					0	0	1	0	0
TRAP1	10131	broad.mit.edu	37	16	3712941	3712941	+	Missense_Mutation	SNP	G	G	A	rs112776374	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3712941G>A	ENST00000575671.1	-	10	1838	c.1109C>T	c.(1108-1110)aCg>aTg	p.T370M	DNASE1_ENST00000414110.2_Intron|TRAP1_ENST00000246957.5_Missense_Mutation_p.T579M|TRAP1_ENST00000538171.1_Missense_Mutation_p.T526M|DNASE1_ENST00000575152.1_3'UTR			Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1	579					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(90;0.0261)				GAGCTCCTCCGTCTCCTTCTC	0.637000													12	10					0	0	1	0	0
CCDC66	285331	broad.mit.edu	37	3	56650074	56650074	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:56650074G>A	ENST00000394672.3	+	13	1906	c.1836G>A	c.(1834-1836)gtG>gtA	p.V612V	CCDC66_ENST00000326595.7_Silent_p.V578V|CCDC66_ENST00000436465.2_Silent_p.V612V	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	612										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		ATACTGGTGTGCAAACAGGTA	0.279000													30	42					0	0	1	0	0
SAP30BP	29115	broad.mit.edu	37	17	73695894	73695894	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73695894G>A	ENST00000584667.1	+	5	596	c.339G>A	c.(337-339)tcG>tcA	p.S113S	SAP30BP_ENST00000355423.3_Silent_p.S97S|SAP30BP_ENST00000579864.1_3'UTR	NM_013260.6	NP_037392.1	Q9UHR5	S30BP_HUMAN	SAP30 binding protein	113					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)	17	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGAACATGTCGCCTGATGAAA	0.453000													42	78					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103061730	103061730	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:103061730G>A	ENST00000264260.2	+	9	1591	c.1002G>A	c.(1000-1002)aaG>aaA	p.K334K	IL18RAP_ENST00000409369.1_Silent_p.K192K	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	334	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						TTCGCAGGAAGTTTGTTTGCT	0.423000													13	33					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11656223	11656223	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:11656223C>T	ENST00000262442.3	+	33	6752	c.6684C>T	c.(6682-6684)ggC>ggT	p.G2228G	DNAH9_ENST00000454412.2_Silent_p.G2228G	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2228	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TACTGGATGGCGACATAGATC	0.433000													21	28					0	0	1	0	0
APOA5	0	broad.mit.edu	37	11	116661762	116661762	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:116661762C>A	ENST00000542499.1	-	4	255	c.183G>T	c.(181-183)gaG>gaT	p.E61D	APOA5_ENST00000227665.4_Missense_Mutation_p.E61D	NM_001166598.1|NM_052968.4	NP_001160070.1|NP_443200.2	Q6Q788	APOA5_HUMAN	apolipoprotein A-V	61					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	14	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		TGAGGTCTTGCTCAAGGCTGT	0.587000													9	10					0.000274275	0.000279654	1	1	0
CYLD	1540	broad.mit.edu	37	16	50828294	50828294	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:50828294G>A	ENST00000540145.1	+	18	3056	c.2641G>A	c.(2641-2643)Gac>Aac	p.D881N	CYLD_ENST00000569418.1_Missense_Mutation_p.D878N|RP11-327F22.4_ENST00000575917.1_RNA|CYLD_ENST00000568704.2_Missense_Mutation_p.D696N|CYLD_ENST00000566206.1_Missense_Mutation_p.D878N|CYLD_ENST00000427738.3_Missense_Mutation_p.D881N|RP11-327F22.4_ENST00000564510.1_RNA|CYLD_ENST00000398568.2_Missense_Mutation_p.D878N|CYLD_ENST00000311559.9_Missense_Mutation_p.D881N|CYLD_ENST00000564326.1_Missense_Mutation_p.D878N			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	881					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				GTATGGGAAGGACGATTCTGC	0.493000			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				20	117					0	0	1	0	0
CCDC97	90324	broad.mit.edu	37	19	41822696	41822696	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41822696A>G	ENST00000269967.3	+	2	576	c.454A>G	c.(454-456)Acc>Gcc	p.T152A		NM_052848.1	NP_443080.1	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	152										biliary_tract(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	17						CACCCTGCGTACCCGCCTGCG	0.682000													16	29					0	0	1	0	0
CEACAM16	388551	broad.mit.edu	37	19	45207440	45207440	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:45207440C>T	ENST00000587331.1	+	4	750	c.535C>T	c.(535-537)Ctg>Ttg	p.L179L	CTB-171A8.1_ENST00000590796.1_RNA|CEACAM16_ENST00000405314.2_Silent_p.L179L	NM_001039213.2	NP_001034302.2	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 16	179										endometrium(3)|large_intestine(2)|lung(3)|ovary(1)	9	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				CCGCCTGGGCCTGTCCCCTGA	0.706000													3	3					0	0	1	0	0
SLC27A1	376497	broad.mit.edu	37	19	17599665	17599665	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17599665G>A	ENST00000252595.7	+	5	900	c.803G>A	c.(802-804)cGc>cAc	p.R268H	SLC27A1_ENST00000442725.1_Missense_Mutation_p.R268H|SLC27A1_ENST00000598424.1_Missense_Mutation_p.R89H	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	268	Sufficient for oligomerization (By similarity).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						AGGTACTACCGCATGGCAGCC	0.657000													5	12					0	0	1	0	0
MYO6	4646	broad.mit.edu	37	6	76538323	76538323	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:76538323G>T	ENST00000369981.3	+	4	533	c.254G>T	c.(253-255)aGa>aTa	p.R85I	MYO6_ENST00000369975.1_Missense_Mutation_p.R85I|MYO6_ENST00000369985.4_Missense_Mutation_p.R85I|MYO6_ENST00000369977.3_Missense_Mutation_p.R85I			Q9UM54	MYO6_HUMAN	myosin VI	85	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AGTAAAGACAGAATTTATGTA	0.289000													33	57					4.4194e-11	4.74656e-11	1	1	0
OPCML	4978	broad.mit.edu	37	11	132398972	132398972	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:132398972C>A	ENST00000331898.7	-	3	1087	c.509G>T	c.(508-510)aGa>aTa	p.R170I	OPCML_ENST00000524381.1_Missense_Mutation_p.R163I|OPCML_ENST00000541867.1_Missense_Mutation_p.R170I|OPCML_ENST00000374778.4_Missense_Mutation_p.R129I|OPCML_ENST00000529038.1_5'UTR	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	170	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity	p.R170K(1)|p.R163K(1)		endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TGACAGGTGTCTCCATGTCAC	0.483000													8	26					5.18039e-06	5.37127e-06	1	1	0
FCRL5	83416	broad.mit.edu	37	1	157509011	157509011	+	Missense_Mutation	SNP	G	G	A	rs149262706		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:157509011G>A	ENST00000361835.3	-	7	1424	c.1267C>T	c.(1267-1269)Cgt>Tgt	p.R423C	FCRL5_ENST00000368189.3_Missense_Mutation_p.R423C|FCRL5_ENST00000368191.3_Missense_Mutation_p.R338C|FCRL5_ENST00000356953.4_Missense_Mutation_p.R423C|FCRL5_ENST00000368190.3_Missense_Mutation_p.R423C	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	423	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GCCGACCTACGCTCCAGGGCA	0.552000													10	4					0	0	1	0	0
TMEM66	51669	broad.mit.edu	37	8	29923592	29923592	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:29923592C>T	ENST00000256255.6	-	5	1163	c.906G>A	c.(904-906)acG>acA	p.T302T	TMEM66_ENST00000545648.1_Silent_p.T130T|TMEM66_ENST00000536273.1_Silent_p.T130T	NM_016127.4	NP_057211.4	Q96BY9	TMM66_HUMAN	transmembrane protein 66	302						integral to membrane				endometrium(2)|large_intestine(1)|lung(11)	14				KIRC - Kidney renal clear cell carcinoma(542;0.0993)|Kidney(114;0.119)		CCCTATTCCACGTGCCAGGGT	0.488000													22	38					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55447772	55447772	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55447772C>T	ENST00000446217.1	-	8	2643	c.2241G>A	c.(2239-2241)gcG>gcA	p.A747A	NLRP7_ENST00000328092.5_Silent_p.A691A|NLRP7_ENST00000448121.2_Silent_p.A691A|NLRP7_ENST00000590030.1_Silent_p.A719A|NLRP7_ENST00000340844.2_Silent_p.A719A|NLRP7_ENST00000592784.1_Silent_p.A719A|NLRP7_ENST00000588756.1_Silent_p.A719A			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	719							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		AGTCCCGGTACGCGGTGTCAG	0.493000													4	16					0	0	1	0	0
C22orf42	150297	broad.mit.edu	37	22	32546394	32546394	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:32546394C>G	ENST00000382097.3	-	7	638	c.566G>C	c.(565-567)aGc>aCc	p.S189T		NM_001010859.1	NP_001010859.1	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	189										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	24						GACAGATAGGCTTTCACTGAG	0.443000													15	82					0	0	1	0	0
PRIM2	5558	broad.mit.edu	37	6	57246965	57246965	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:57246965C>T	ENST00000607273.1	+	7	779	c.693_splice	c.e7+1	p.A231_splice	PRIM2_ENST00000389488.2_3'UTR	NM_000947.2	NP_000938.2	P49643	PRI2_HUMAN	primase, DNA, polypeptide 2 (58kDa)	231					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(34)|prostate(6)|stomach(4)|upper_aerodigestive_tract(1)	59				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		AAGGCTTTGGCAGTGAGTATT	0.368000													6	45					0	0	1	0	0
RAB39A	54734	broad.mit.edu	37	11	107832960	107832960	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:107832960G>A	ENST00000320578.2	+	2	582	c.516G>A	c.(514-516)acG>acA	p.T172T		NM_017516.1	NP_059986.1	Q14964	RB39A_HUMAN	RAB39A, member RAS oncogene family	172					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding										CAATCTTGACGAGAGACATAT	0.383000													20	27					0	0	1	0	0
TRMU	55687	broad.mit.edu	37	22	46752742	46752742	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:46752742G>A	ENST00000290846.4	+	11	1445	c.1105G>A	c.(1105-1107)Gct>Act	p.A369T	TRMU_ENST00000381019.3_Missense_Mutation_p.C341Y	NM_018006.4	NP_060476.2	O75648	MTU1_HUMAN	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase	369						mitochondrion	ATP binding|sulfurtransferase activity|tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity|tRNA binding			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)	10		Ovarian(80;0.00965)|Breast(42;0.0194)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00449)|LUAD - Lung adenocarcinoma(64;0.248)		CCTACAGTTTGCTGTGTTCTA	0.672000													29	55					0	0	1	0	0
C1QB	713	broad.mit.edu	37	1	22987584	22987584	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:22987584G>A	ENST00000509305.1	+	3	807	c.461G>A	c.(460-462)cGc>cAc	p.R154H	C1QB_ENST00000314933.6_Missense_Mutation_p.R156H			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	156	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TATGAGCCCCGCAGTGGCAAG	0.592000													12	46					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55221778	55221778	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:55221778G>A	ENST00000275493.2	+	7	999	c.822G>A	c.(820-822)acG>acA	p.T274T	EGFR_ENST00000454757.2_Silent_p.T221T|EGFR_ENST00000420316.2_Silent_p.T274T|EGFR_ENST00000442591.1_Silent_p.T274T|EGFR_ENST00000455089.1_Silent_p.T229T|EGFR_ENST00000344576.2_Silent_p.T274T|EGFR_ENST00000342916.3_Silent_p.T274T	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	274					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ACCCCACCACGTACCAGATGG	0.592000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			22	22					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18059601	18059601	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18059601C>T	ENST00000205890.5	+	48	8890	c.8552C>T	c.(8551-8553)gCg>gTg	p.A2851V	MYO15A_ENST00000418233.3_Missense_Mutation_p.A115V	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2851	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TCAGCCCGAGCGCACCAGGTC	0.547000													12	29					0	0	1	0	0
CARF	79800	broad.mit.edu	37	2	203839189	203839189	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:203839189G>A	ENST00000320443.8	+	12	2507	c.1464G>A	c.(1462-1464)acG>acA	p.T488T	WDR12_ENST00000477723.1_Intron|CARF_ENST00000438828.2_Silent_p.T488T|CARF_ENST00000428585.1_Silent_p.T412T|CARF_ENST00000402905.2_Silent_p.T488T|CARF_ENST00000414439.1_Silent_p.T386T|CARF_ENST00000545253.1_Silent_p.T400T|CARF_ENST00000545262.1_Silent_p.T412T					calcium responsive transcription factor									p.T488T(1)									ATGGAGATACGGTATATAACT	0.308000													9	42					0	0	1	0	0
BRMS1	25855	broad.mit.edu	37	11	66108293	66108293	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66108293G>A	ENST00000359957.3	-	6	647	c.487C>T	c.(487-489)Cgg>Tgg	p.R163W	BRMS1_ENST00000425825.2_Missense_Mutation_p.R163W	NM_015399.3	NP_056214.1	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1	163					apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding			large_intestine(1)|liver(1)|lung(1)|prostate(1)|skin(1)	5						CTCTGGATCCGCTCCTGCAGC	0.657000													22	26					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151503053	151503053	+	Missense_Mutation	SNP	G	G	A	rs149778114		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151503053G>A	ENST00000271636.7	+	13	2535	c.2402G>A	c.(2401-2403)cGc>cAc	p.R801H		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	795	Glu-rich.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTGGAGGCACGCCTAGAGGAG	0.687000													11	11					0	0	1	0	0
BRF2	55290	broad.mit.edu	37	8	37702215	37702215	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:37702215C>T	ENST00000220659.6	-	4	1173	c.1053G>A	c.(1051-1053)ccG>ccA	p.P351P	GPR124_ENST00000315215.7_3'UTR	NM_018310.3	NP_060780.2	Q9HAW0	BRF2_HUMAN	BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit	351					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)	12		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			CAGGACTGGCCGGCCGCTTCC	0.592000													3	19					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99440488	99440488	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:99440488C>T	ENST00000287042.4	+	2	631	c.281C>T	c.(280-282)gCt>gTt	p.A94V	KCNS2_ENST00000521839.1_Missense_Mutation_p.A94V	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	94						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CACGTCATGGCTGAGCTATGT	0.547000													40	57					0	0	1	0	0
PAX3	5077	broad.mit.edu	37	2	223160315	223160315	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:223160315A>G	ENST00000350526.4	-	3	519	c.383T>C	c.(382-384)aTg>aCg	p.M128T	PAX3_ENST00000258387.5_Missense_Mutation_p.M128T|PAX3_ENST00000409828.3_Missense_Mutation_p.M128T|PAX3_ENST00000409551.3_Missense_Mutation_p.M127T|PAX3_ENST00000392070.2_Missense_Mutation_p.M128T|PAX3_ENST00000336840.6_Missense_Mutation_p.M128T|PAX3_ENST00000392069.2_Missense_Mutation_p.M128T|PAX3_ENST00000344493.4_Missense_Mutation_p.M128T	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	128	Paired.				apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCAGCTGAACATGCCCGGGTT	0.542000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						3	59					0	0	1	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174190300	174190300	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:174190300C>T	ENST00000251507.4	+	3	503	c.329C>T	c.(328-330)aCa>aTa	p.T110I	RABGAP1L_ENST00000367689.3_5'UTR|RABGAP1L_ENST00000357444.6_Missense_Mutation_p.T73I	NM_014857.4	NP_055672.3	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	110					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						CCGTCTAACACAGGTACTGTA	0.328000													25	56					0	0	1	0	0
MAP7D1	55700	broad.mit.edu	37	1	36643582	36643582	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:36643582C>T	ENST00000316156.4	+	8	1830	c.1377C>T	c.(1375-1377)tcC>tcT	p.S459S	MAP7D1_ENST00000373150.4_Silent_p.S464S|MAP7D1_ENST00000373148.4_Silent_p.S42S|MAP7D1_ENST00000373151.2_Silent_p.S496S			Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	496						cytoplasm|spindle				breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	19		Myeloproliferative disorder(586;0.0393)				AGCCACCGTCCCCCCGAGGCA	0.701000													13	18					0	0	1	0	0
ZNF251	90987	broad.mit.edu	37	8	145947855	145947855	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145947855C>T	ENST00000292562.7	-	5	1465	c.1190G>A	c.(1189-1191)cGg>cAg	p.R397Q	ZNF251_ENST00000524394.1_Intron	NM_138367.1	NP_612376.1	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|kidney(1)|large_intestine(5)|lung(9)|stomach(1)	17	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		AGTATGAACCCGATGATGGAG	0.448000													46	89					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66358932	66358932	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66358932C>A	ENST00000333861.3	-	1	1622	c.1555G>T	c.(1555-1557)Gca>Tca	p.A519S		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	519										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						TCTTTATCTGCTGCAGGCTCA	0.488000													42	55					2.2871e-25	2.55332e-25	1	1	0
NBEAL2	23218	broad.mit.edu	37	3	47042568	47042568	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47042568C>T	ENST00000450053.3	+	28	4562	c.4383C>T	c.(4381-4383)agC>agT	p.S1461S	NBEAL2_ENST00000292309.5_Silent_p.S1277S|NBEAL2_ENST00000383740.2_5'UTR	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1461							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TGGAAGGCAGCGATGAGGCTG	0.622000													7	10					0	0	1	0	0
FAM172A	83989	broad.mit.edu	37	5	93217230	93217230	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:93217230A>G	ENST00000395965.3	-	7	874	c.732T>C	c.(730-732)taT>taC	p.Y244Y	FAM172A_ENST00000509739.1_Silent_p.Y97Y|FAM172A_ENST00000505869.1_Silent_p.Y134Y|FAM172A_ENST00000509163.1_Silent_p.Y198Y	NM_032042.5	NP_114431.2	Q8WUF8	F172A_HUMAN	family with sequence similarity 172, member A	244						endoplasmic reticulum|extracellular region				endometrium(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9						GATACTTCTCATAGAAATCAC	0.348000													39	77					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48614416	48614416	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:48614416A>G	ENST00000297423.4	+	13	2291	c.1907A>G	c.(1906-1908)gAc>gGc	p.D636G	SPIDR_ENST00000517693.1_Missense_Mutation_p.D111G|SPIDR_ENST00000521214.1_3'UTR|SPIDR_ENST00000518074.1_Missense_Mutation_p.D576G|SPIDR_ENST00000541342.1_Missense_Mutation_p.D566G	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		TGCTTAAGAGACATTCTCCAG	0.418000													97	110					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64395427	64395427	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:64395427G>A	ENST00000262043.3	+	4	2144	c.1804G>A	c.(1804-1806)Gct>Act	p.A602T	PHF3_ENST00000393387.1_Missense_Mutation_p.A602T|PHF3_ENST00000509330.1_Missense_Mutation_p.A602T			Q92576	PHF3_HUMAN	PHD finger protein 3	602					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TAAGTCACACGCTCATCCTGG	0.408000													18	32					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141580778	141580778	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:141580778G>A	ENST00000442267.2	-	11	1959	c.1885C>T	c.(1885-1887)Cgc>Tgc	p.R629C		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	629	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				GGGAGCATGCGCTCACACAAA	0.443000													3	6					0	0	1	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161167892	161167892	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161167892G>A	ENST00000367996.4	-	1	954	c.526C>T	c.(526-528)Cct>Tct	p.P176S	ADAMTS4_ENST00000367995.3_Missense_Mutation_p.P176S	NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	176					proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TGAGCCCCAGGTCCCCCAGCA	0.642000													17	17					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235943651	235943651	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:235943651C>T	ENST00000409212.1	+	3	512	c.5C>T	c.(4-6)gCg>gTg	p.A2V	SH3BP4_ENST00000344528.4_Missense_Mutation_p.A2V|SH3BP4_ENST00000392011.2_Missense_Mutation_p.A2V			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	2					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		TTCGAGATGGCGGCTCAGCGG	0.557000													12	11					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54305717	54305717	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:54305717C>T	ENST00000545554.1	+	1	617	c.617C>T	c.(616-618)tCc>tTc	p.S206F	UNC13C_ENST00000260323.11_Missense_Mutation_p.S206F|UNC13C_ENST00000537900.1_Missense_Mutation_p.S206F			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	206					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATGAAAAAATCCTGGGGAATA	0.438000													35	59					0	0	1	0	0
IL17REL	400935	broad.mit.edu	37	22	50437876	50437876	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50437876G>A	ENST00000389983.2	-	8	794	c.530C>T	c.(529-531)cCg>cTg	p.P177L	IL17REL_ENST00000341280.5_Missense_Mutation_p.P177L	NM_001001694.2	NP_001001694.2	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	177										endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GCACAGGCACGGCAGCTCCTG	0.716000													6	6					0	0	1	0	0
TXNIP	10628	broad.mit.edu	37	1	145438944	145438944	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145438944G>T	ENST00000369317.4	+	1	476	c.142G>T	c.(142-144)Gct>Tct	p.A48S	TXNIP_ENST00000475171.1_Intron	NM_006472.3	NP_006463.3	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	48					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	21	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TAGGATCCTGGCTTGCGGAGT	0.542000													25	24					7.41945e-09	7.84611e-09	1	1	0
PDLIM5	10611	broad.mit.edu	37	4	95575717	95575717	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:95575717G>A	ENST00000317968.4	+	10	1526	c.1390G>A	c.(1390-1392)Gcc>Acc	p.A464T	PDLIM5_ENST00000542407.1_Missense_Mutation_p.A342T|PDLIM5_ENST00000514743.1_Missense_Mutation_p.A493T|PDLIM5_ENST00000380176.3_3'UTR|PDLIM5_ENST00000437932.1_Missense_Mutation_p.A355T	NM_001256428.1|NM_006457.4	NP_001243357.1|NP_006448.4	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5	464	LIM zinc-binding 1.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		GGAGAAAGGAGCCCTGTATTG	0.433000													26	65					0	0	1	0	0
EYA2	2139	broad.mit.edu	37	20	45797813	45797813	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:45797813C>T	ENST00000327619.5	+	11	1379	c.1005C>T	c.(1003-1005)gaC>gaT	p.D335D	EYA2_ENST00000317304.6_Silent_p.D305D|EYA2_ENST00000357410.3_Silent_p.D335D	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	335					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				ACGTTGATGACGTCTCATCAG	0.418000													37	74					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1265558	1265558	+	Missense_Mutation	SNP	G	G	A	rs61372944		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1265558G>A	ENST00000348261.5	+	30	5457	c.5209G>A	c.(5209-5211)Gcc>Acc	p.A1737T	CACNA1H_ENST00000565831.1_Missense_Mutation_p.A1731T|CACNA1H_ENST00000358590.4_Missense_Mutation_p.A1731T	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1737					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGGCATGCGCGCCCTGCTGGA	0.711000													4	16					0	0	1	0	0
PAK3	5063	broad.mit.edu	37	X	110439716	110439716	+	Nonsense_Mutation	SNP	C	C	T	rs121434611		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:110439716C>T	ENST00000519681.1	+	17	1760	c.1318C>T	c.(1318-1320)Cga>Tga	p.R440*	PAK3_ENST00000360648.4_Nonsense_Mutation_p.R455*|PAK3_ENST00000417227.1_Nonsense_Mutation_p.R440*|PAK3_ENST00000262836.4_Nonsense_Mutation_p.R434*|PAK3_ENST00000425146.1_Nonsense_Mutation_p.R419*|PAK3_ENST00000372007.4_Nonsense_Mutation_p.R419*|PAK3_ENST00000446737.1_Nonsense_Mutation_p.R419*|PAK3_ENST00000372010.1_Nonsense_Mutation_p.R434*|PAK3_ENST00000518291.1_Nonsense_Mutation_p.R455*			O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3	434	Protein kinase.		T -> S (in a colorectal adenocarcinoma sample; somatic mutation).		multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding	p.R419*(1)		breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						GCAAAGTAAACGAAGCACTAT	0.433000										TSP Lung(19;0.15)			29	9					0	0	1	0	0
HFE2	148738	broad.mit.edu	37	1	145416688	145416688	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:145416688C>T	ENST00000336751.5	+	4	1271	c.1033C>T	c.(1033-1035)Cgg>Tgg	p.R345W	HFE2_ENST00000475797.1_Missense_Mutation_p.R119W|HFE2_ENST00000357836.5_Missense_Mutation_p.R232W|HFE2_ENST00000497365.1_Missense_Mutation_p.R119W	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	345					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TACTGCCAGACGGCTGTGCAA	0.522000													13	24					0	0	1	0	0
LFNG	3955	broad.mit.edu	37	7	2564899	2564899	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2564899G>A	ENST00000222725.5	+	3	548	c.528G>A	c.(526-528)gcG>gcA	p.A176A	LFNG_ENST00000402045.1_Silent_p.A47A|LFNG_ENST00000359574.3_Silent_p.A176A|LFNG_ENST00000338732.3_Silent_p.A47A|LFNG_ENST00000402506.1_Silent_p.A105A	NM_001040167.1	NP_001035257.1	Q8NES3	LFNG_HUMAN	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	176					organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)|urinary_tract(2)	6		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		GCCGCCAGGCGCTGTCCTGCA	0.672000													15	7					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	30724564	30724564	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:30724564C>T	ENST00000361762.2	+	1	2528	c.1520C>T	c.(1519-1521)gCg>gTg	p.A507V	PCDH7_ENST00000543491.1_Missense_Mutation_p.A507V	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	507	Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						GTCATCGTGGCGGTGGACTCA	0.597000													8	10					0	0	1	0	0
PGAM2	5224	broad.mit.edu	37	7	44102514	44102514	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44102514G>A	ENST00000297283.3	-	3	668	c.611C>T	c.(610-612)gCg>gTg	p.A204V		NM_000290.3	NP_000281.2	P15259	PGAM2_HUMAN	phosphoglycerate mutase 2 (muscle)	204					gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity			large_intestine(2)|lung(4)|ovary(1)|stomach(1)	8						CTCCATGATCGCCTGGTCTGA	0.547000													21	24					0	0	1	0	0
IFI35	3430	broad.mit.edu	37	17	41165610	41165610	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41165610G>A	ENST00000415816.2	+	5	716	c.493G>A	c.(493-495)Gga>Aga	p.G165R	IFI35_ENST00000438323.2_Missense_Mutation_p.G167R	NM_005533.4	NP_005524.2	P80217	IN35_HUMAN	interferon-induced protein 35	165					response to virus|type I interferon-mediated signaling pathway	nucleus	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)	8		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.157)		GACTAGGAACGGAGGTGGCGA	0.597000													72	88					0	0	1	0	0
RSBN1	54665	broad.mit.edu	37	1	114310903	114310903	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:114310903C>A	ENST00000261441.5	-	5	1830	c.1767G>T	c.(1765-1767)ggG>ggT	p.G589G		NM_018364.3	NP_060834.2	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	589						nucleus				breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(3)|urinary_tract(2)	29	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCAGTCAAACCCCTGACCGA	0.438000													29	29					2.12542e-12	2.29988e-12	1	1	0
KAT6B	23522	broad.mit.edu	37	10	76732345	76732345	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:76732345C>T	ENST00000287239.4	+	7	1498	c.1009C>T	c.(1009-1011)Cga>Tga	p.R337*	KAT6B_ENST00000372724.1_Nonsense_Mutation_p.R337*|KAT6B_ENST00000372714.1_Nonsense_Mutation_p.R337*|KAT6B_ENST00000372725.1_Nonsense_Mutation_p.R337*|KAT6B_ENST00000372711.1_Nonsense_Mutation_p.R337*	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	337					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										AATAAAACGACGATATGCAAA	0.328000													47	64					0	0	1	0	0
DPYSL2	1808	broad.mit.edu	37	8	26481823	26481823	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:26481823G>A	ENST00000311151.5	+	4	890	c.478_splice	c.e4+1	p.G160_splice	DPYSL2_ENST00000523027.1_Splice_Site_p.G124_splice|DPYSL2_ENST00000521913.1_Splice_Site_p.G124_splice	NM_001386.5	NP_001377.1	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	160					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			breast(1)|endometrium(5)|large_intestine(8)|lung(3)|prostate(1)|skin(1)|stomach(1)	20		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		GAAGGATCACGGTAGGTTGCA	0.527000													20	38					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520426	131520426	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:131520426C>T	ENST00000423981.1	+	2	891	c.781C>T	c.(781-783)Cca>Tca	p.P261S	AMER3_ENST00000321420.4_Missense_Mutation_p.P261S	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GAGCTCGGTGCCATCTCTGGA	0.647000													10	40					0	0	1	0	0
GAS7	8522	broad.mit.edu	37	17	9820569	9820569	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:9820569G>A	ENST00000396115.1	-	14	1537	c.1227C>T	c.(1225-1227)atC>atT	p.I409I	GAS7_ENST00000542249.1_Silent_p.I414I|GAS7_ENST00000437099.2_Silent_p.I405I|GAS7_ENST00000580865.1_Silent_p.I329I|GAS7_ENST00000579158.1_Silent_p.I421I|GAS7_ENST00000585266.1_Silent_p.I405I|GAS7_ENST00000432992.2_Silent_p.I469I|GAS7_ENST00000323816.4_Silent_p.I405I|GAS7_ENST00000583882.1_Intron|GAS7_ENST00000540214.1_Silent_p.I174I	NM_201432.1	NP_958836.1	O60861	GAS7_HUMAN	growth arrest-specific 7	469					cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(7)|lung(18)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	39						CCACAGGGCGGATGTTGCCCG	0.637000			T	MLL	AML*								15	50					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54545614	54545614	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54545614G>A	ENST00000338372.2	-	5	579	c.404C>T	c.(403-405)aCc>aTc	p.T135I	VSTM1_ENST00000376626.1_Intron|VSTM1_ENST00000366170.2_Missense_Mutation_p.T47I|VSTM1_ENST00000425006.2_3'UTR	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	135						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		GACAAAGATGGTTCTGGTGTC	0.532000													3	11					0	0	1	0	0
C11orf70	85016	broad.mit.edu	37	11	101946621	101946621	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:101946621C>T	ENST00000534360.1	+	4	299	c.286C>T	c.(286-288)Ctc>Ttc	p.L96F	C11orf70_ENST00000526781.1_Silent_p.D151D|C11orf70_ENST00000434758.2_Silent_p.D151D	NM_001195005.1	NP_001181934.1	Q9BRQ4	CK070_HUMAN	chromosome 11 open reading frame 70	0										breast(1)|kidney(1)|lung(5)|ovary(1)|prostate(2)|skin(2)	12	all_epithelial(12;0.0137)	Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.0137)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0335)		TAGTGGAAGACTCAGAAAAAT	0.323000													30	23					0	0	1	0	0
SOWAHC	65124	broad.mit.edu	37	2	110373357	110373357	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:110373357G>A	ENST00000356454.3	+	1	1447	c.1291G>A	c.(1291-1293)Gcc>Acc	p.A431T		NM_023016.3	NP_075392.2	Q53LP3	ANR57_HUMAN	sosondowah ankyrin repeat domain family member C	431																	ACTCTCACACGCCCTAGAAGA	0.642000													10	12					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44929288	44929288	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:44929288C>T	ENST00000377967.4	+	17	2429	c.2388C>T	c.(2386-2388)acC>acT	p.T796T	KDM6A_ENST00000543216.1_Silent_p.T717T|KDM6A_ENST00000536777.1_Silent_p.T751T|KDM6A_ENST00000382899.4_Silent_p.T803T	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	796					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						GTACTGGAACCTGTGACAAAG	0.443000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								13	1					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155451307	155451307	+	Missense_Mutation	SNP	G	G	A	rs146734733		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:155451307G>A	ENST00000461783.3	+	6	2223	c.950G>A	c.(949-951)cGc>cAc	p.R317H	TIAM2_ENST00000529824.2_Missense_Mutation_p.R317H|TIAM2_ENST00000360366.4_Missense_Mutation_p.R317H|TIAM2_ENST00000318981.5_Missense_Mutation_p.R317H|TIAM2_ENST00000456144.1_Missense_Mutation_p.R317H|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	317					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TCAGGTATCCGCCTTTCTGAT	0.572000													6	26					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87816006	87816006	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:87816006C>T	ENST00000398209.3	+	29	2591	c.2545C>T	c.(2545-2547)Cca>Tca	p.P849S	ADAM22_ENST00000315984.7_Missense_Mutation_p.P849S|ADAM22_ENST00000265727.7_Intron|ADAM22_ENST00000398204.4_Intron	NM_021722.4	NP_068368.2	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	859					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CACTGAAGGACCATACTTTAG	0.353000													38	78					0	0	1	0	0
CCDC150	284992	broad.mit.edu	37	2	197540891	197540891	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:197540891A>G	ENST00000389175.4	+	11	1297	c.1162A>G	c.(1162-1164)Aca>Gca	p.T388A	CCDC150_ENST00000472405.2_3'UTR|CCDC150_ENST00000423093.2_Missense_Mutation_p.T56A|CCDC150_ENST00000272831.7_Missense_Mutation_p.T56A	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	388										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GATGACGCAGACATTTCAAGA	0.403000													22	41					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152749427	152749427	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152749427G>A	ENST00000367255.5	-	37	5490	c.4889C>T	c.(4888-4890)gCg>gTg	p.A1630V	SYNE1_ENST00000367253.4_Missense_Mutation_p.A1630V|SYNE1_ENST00000448038.1_Missense_Mutation_p.A1637V|SYNE1_ENST00000341594.5_Missense_Mutation_p.A1700V|SYNE1_ENST00000423061.1_Missense_Mutation_p.A1637V|SYNE1_ENST00000265368.4_Missense_Mutation_p.A1630V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1630					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGTAGAGCCGCAGCCTCCTG	0.587000										HNSCC(10;0.0054)			54	41					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160182235	160182235	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:160182235C>T	ENST00000392783.2	-	35	6633	c.6138G>A	c.(6136-6138)ttG>ttA	p.L2046L	BAZ2B_ENST00000343439.5_Silent_p.L1946L|BAZ2B_ENST00000355831.2_Silent_p.L2012L|BAZ2B_ENST00000392782.1_Silent_p.L2010L	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	2046					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						CTTGTTTTGACAAGTTAATAG	0.343000													19	59					0	0	1	0	0
GRIA4	0	broad.mit.edu	37	11	105483076	105483076	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:105483076C>T	ENST00000393127.2	+	3	608	c.162C>T	c.(160-162)agC>agT	p.S54S	GRIA4_ENST00000428631.2_Silent_p.S54S|GRIA4_ENST00000393125.2_Silent_p.S54S|GRIA4_ENST00000527669.1_Silent_p.S54S|GRIA4_ENST00000282499.5_Silent_p.S54S|GRIA4_ENST00000530497.1_Silent_p.S54S|GRIA4_ENST00000525187.1_Silent_p.S54S	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	54				S -> A (in Ref. 1; AAA95962).	glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATAACACCAGCCCCAATGCGT	0.403000													16	71					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37176039	37176039	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:37176039G>A	ENST00000274258.7	-	31	6177	c.2590C>T	c.(2590-2592)Caa>Taa	p.Q864*	C5orf42_ENST00000508244.1_Nonsense_Mutation_p.Q1984*|C5orf42_ENST00000425232.2_Nonsense_Mutation_p.Q1984*			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1984										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GTATCTACTTGCATTGATTGA	0.338000													33	72					0	0	1	0	0
RBBP9	10741	broad.mit.edu	37	20	18470588	18470588	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:18470588G>A	ENST00000337227.4	-	5	456	c.381C>T	c.(379-381)tgC>tgT	p.C127C	RBBP9_ENST00000493184.1_5'UTR	NM_006606.2	NP_006597.2	O75884	RBBP9_HUMAN	retinoblastoma binding protein 9	127						cytoplasm|nucleus	hydrolase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|prostate(1)	9						CAATGTAAGGGCAGTTGGCCT	0.473000													16	27					0	0	1	0	0
LINC00482	0	broad.mit.edu	37	17	79278503	79278503	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79278503C>T	ENST00000332012.5	-	0	1090					NR_038080.1																						CCCCTTGGCGCTGGCCTTGGC	0.647000													4	7					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200880619	200880619	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:200880619G>A	ENST00000367342.4	+	9	1453	c.1253G>A	c.(1252-1254)cGc>cAc	p.R418H	C1orf106_ENST00000413687.2_Missense_Mutation_p.R333H	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	418										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						GGCCGAGGTCGCAGCGCCTTT	0.672000													74	89					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22990197	22990197	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:22990197C>T	ENST00000313077.7	+	24	2942	c.2817C>T	c.(2815-2817)agC>agT	p.S939S	CYFIP1_ENST00000560848.1_Silent_p.S939S|CYFIP1_ENST00000435939.2_Silent_p.S508S	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	939					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TCGTCAAGAGCCTGGTGAGTG	0.572000													7	45					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90428725	90428725	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:90428725C>T	ENST00000369393.3	-	42	6197	c.6082G>A	c.(6082-6084)Ggg>Agg	p.G2028R	MDN1_ENST00000428876.1_Missense_Mutation_p.G2028R			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	2028					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACACAGCTCCCACGGGAAAGG	0.512000													10	25					0	0	1	0	0
P4HTM	54681	broad.mit.edu	37	3	49038923	49038923	+	Silent	SNP	G	G	A	rs143747733	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49038923G>A	ENST00000343546.4	+	3	857	c.489G>A	c.(487-489)gcG>gcA	p.A163A	P4HTM_ENST00000468374.1_3'UTR|P4HTM_ENST00000383729.4_Silent_p.A163A	NM_177938.2	NP_808807.2	Q9NXG6	P4HTM_HUMAN	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	163						endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21					Vitamin C(DB00126)	TCCATCTGGCGCAGATGAAGG	0.582000													15	15					0	0	1	0	0
HRH4	59340	broad.mit.edu	37	18	22040736	22040736	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:22040736G>A	ENST00000256906.4	+	1	144	c.44G>A	c.(43-45)cGt>cAt	p.R15H	HRH4_ENST00000426880.2_Missense_Mutation_p.R15H	NM_001160166.1|NM_021624.3	NP_001153638.1|NP_067637.2	Q9H3N8	HRH4_HUMAN	histamine receptor H4	15						integral to membrane|plasma membrane	histamine receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	CTAAGCACTCGTGTTACTTTA	0.343000													34	57					0	0	1	0	0
SUN2	25777	broad.mit.edu	37	22	39144768	39144768	+	Missense_Mutation	SNP	G	G	A	rs142155226	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:39144768G>A	ENST00000405510.1	-	8	993	c.635C>T	c.(634-636)aCg>aTg	p.T212M	SUN2_ENST00000405018.1_Missense_Mutation_p.T233M|RP3-508I15.14_ENST00000416406.1_RNA|SUN2_ENST00000411587.2_Missense_Mutation_p.T201M|SUN2_ENST00000406622.1_Missense_Mutation_p.T212M|SUN2_ENST00000216064.4_Missense_Mutation_p.T212M	NM_001199580.1	NP_001186509.1	Q9UH99	SUN2_HUMAN	Sad1 and UNC84 domain containing 2	212					centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(2)|stomach(1)	15						CCAGAGGAACGTCTTCAGGGA	0.647000													23	48					0	0	1	0	0
IKBIP	121457	broad.mit.edu	37	12	99020056	99020056	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:99020056G>A	ENST00000299157.4	-	3	1159	c.786C>T	c.(784-786)taC>taT	p.Y262Y	IKBIP_ENST00000420861.1_Intron|IKBIP_ENST00000393042.3_Intron|IKBIP_ENST00000342502.2_Intron	NM_153687.3	NP_710154.1	Q70UQ0	IKIP_HUMAN	IKBKB interacting protein	266					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	6						CTTTGGGTTCGTAGTCGGAAA	0.408000													40	61					0	0	1	0	0
HBB	3043	broad.mit.edu	37	11	5248219	5248219	+	Silent	SNP	G	G	A	rs67440443		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5248219G>A	ENST00000335295.3	-	1	208	c.33C>T	c.(31-33)gcC>gcT	p.A11A		NM_000518.4	NP_000509.1	P68871	HBB_HUMAN	hemoglobin, beta	11			A -> D (in Ankara; dbSNP:rs33947457).|A -> V (in Iraq-Halabja).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)	15		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	GGGCAGTAACGGCAGACTTCT	0.498000									Sickle Cell Trait		OREG0003733	type=REGULATORY REGION|Gene=HBB|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	21	24					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37866372	37866372	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:37866372G>A	ENST00000406381.2	+	8	1097	c.587G>A	c.(586-588)cGc>cAc	p.R196H	ERBB2_ENST00000445658.2_Intron|ERBB2_ENST00000269571.5_Missense_Mutation_p.R226H|ERBB2_ENST00000584601.1_Missense_Mutation_p.R196H|ERBB2_ENST00000541774.1_Missense_Mutation_p.R211H|ERBB2_ENST00000584450.1_Missense_Mutation_p.R226H|ERBB2_ENST00000540042.1_Missense_Mutation_p.R196H|ERBB2_ENST00000540147.1_Missense_Mutation_p.R196H|ERBB2_ENST00000578199.1_Missense_Mutation_p.R196H	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	226					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GGCTGTGCCCGCTGCAAGGGG	0.652000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			39	50					0	0	1	0	0
OR6K3	391114	broad.mit.edu	37	1	158686968	158686968	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158686968G>T	ENST00000368146.1	-	1	985	c.986C>A	c.(985-987)cCt>cAt	p.P329H	OR6K3_ENST00000368145.1_Missense_Mutation_p.P313H			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	329					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					TTAACCTCCAGGCTTGTTCAA	0.408000													39	61					2.35958e-20	2.61572e-20	1	1	0
SLC12A7	10723	broad.mit.edu	37	5	1083909	1083909	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1083909G>A	ENST00000264930.5	-	8	1123	c.1080C>T	c.(1078-1080)aaC>aaT	p.N360N		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	360					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	TTTCGGTGACGTTGTTCTGGA	0.667000													9	24					0	0	1	0	0
TMCC3	57458	broad.mit.edu	37	12	94975899	94975899	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:94975899C>T	ENST00000261226.4	-	2	625	c.494G>A	c.(493-495)cGc>cAc	p.R165H	TMCC3_ENST00000551457.1_Missense_Mutation_p.R134H	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	165						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						TTTCAAAGAGCGATGTATATC	0.498000													6	85					0	0	1	0	0
PITX2	5308	broad.mit.edu	37	4	111553615	111553615	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:111553615T>C	ENST00000354925.2	-	5	1773	c.68A>G	c.(67-69)gAa>gGa	p.E23G	PITX2_ENST00000394598.2_Missense_Mutation_p.E23G|PITX2_ENST00000355080.5_Intron|PITX2_ENST00000394595.3_Missense_Mutation_p.E23G	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	23					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		GAAGAGACATTCAACGGCCGC	0.662000													14	27					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13346502	13346502	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13346502C>T	ENST00000360228.5	-	32	4992	c.4993G>A	c.(4993-4995)Gcc>Acc	p.A1665T	CACNA1A_ENST00000573710.2_Missense_Mutation_p.A1666T|CACNA1A_ENST00000574822.1_5'UTR	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1666					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ATGAGCCGGGCAGCTCGGAAG	0.562000											OREG0025293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	25					0	0	1	0	0
PRR5-ARHGAP8	0	broad.mit.edu	37	22	45182350	45182350	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:45182350C>T	ENST00000352766.7	+	8	705	c.705C>T	c.(703-705)gaC>gaT	p.D235D	ARHGAP8_ENST00000469872.1_3'UTR|ARHGAP8_ENST00000356099.6_5'UTR|ARHGAP8_ENST00000336963.4_5'UTR|ARHGAP8_ENST00000389773.5_Silent_p.D103D|ARHGAP8_ENST00000517296.3_Silent_p.D235D|ARHGAP8_ENST00000389774.2_5'UTR|PRR5-ARHGAP8_ENST00000361473.5_Silent_p.D112D																breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(10)|prostate(1)|skin(8)	30						TGCAGAGAGACAAGGCGGCGG	0.592000													3	0					0	0	1	0	0
TMEM87A	25963	broad.mit.edu	37	15	42523405	42523405	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42523405A>G	ENST00000389834.4	-	12	1380	c.1116T>C	c.(1114-1116)acT>acC	p.T372T	TMEM87A_ENST00000448392.1_Silent_p.T311T	NM_015497.3	NP_056312.2	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A	372						integral to membrane				breast(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		AGCACAAGGCAGTGTCTAGGA	0.448000													5	26					0	0	1	0	0
SHBG	6462	broad.mit.edu	37	17	7536652	7536652	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7536652C>T	ENST00000380450.4	+	8	1222	c.1191C>T	c.(1189-1191)ggC>ggT	p.G397G	SHBG_ENST00000575314.1_Silent_p.G339G|SHBG_ENST00000416273.3_3'UTR|SHBG_ENST00000570547.1_Silent_p.G224G|SHBG_ENST00000576478.1_Silent_p.G170G|SHBG_ENST00000572182.1_3'UTR|SHBG_ENST00000574539.1_3'UTR|SHBG_ENST00000572262.1_Silent_p.G285G|SHBG_ENST00000441599.2_Silent_p.G282G|SHBG_ENST00000575903.1_Silent_p.G379G|SHBG_ENST00000576728.1_3'UTR	NM_001040.3	NP_001031.2	P04278	SHBG_HUMAN	sex hormone-binding globulin	397					hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.0?(1)|p.?(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	CAGGCAATGGCACTGACGCTT	0.493000													6	13					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143018815	143018815	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:143018815A>G	ENST00000343257.2	+	5	657	c.570A>G	c.(568-570)ggA>ggG	p.G190G	CLCN1_ENST00000495612.1_3'UTR	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	190					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					TAGGCTCTGGAATCCCCGAAA	0.498000													9	53					0	0	1	0	0
SLC30A7	148867	broad.mit.edu	37	1	101377677	101377677	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:101377677G>T	ENST00000370112.4	+	5	581	c.394G>T	c.(394-396)Gcc>Tcc	p.A132S	SLC30A7_ENST00000357650.4_Missense_Mutation_p.A132S	NM_001144884.1|NM_133496.4	NP_001138356.1|NP_598003.2	Q8NEW0	ZNT7_HUMAN	solute carrier family 30 (zinc transporter), member 7	132					zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(2)|lung(10)	15		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)		GAGAGCATTAGCCCCTCCAGA	0.348000													68	111					3.89499e-28	4.3593e-28	1	1	0
WNT2B	7482	broad.mit.edu	37	1	113058958	113058958	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:113058958G>T	ENST00000369684.4	+	3	1085	c.600G>T	c.(598-600)aaG>aaT	p.K200N	WNT2B_ENST00000256640.5_Missense_Mutation_p.K108N|WNT2B_ENST00000369686.4_Missense_Mutation_p.K181N|WNT2B_ENST00000478360.1_3'UTR	NM_024494.2	NP_078613.1	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family, member 2B	200					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|stomach(1)	18	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTTTTGCCAAGGCCTTCGTGG	0.572000													5	54					0.184627	0.185007	1	1	0
PPP6R2	9701	broad.mit.edu	37	22	50832367	50832367	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50832367G>A	ENST00000359139.3	+	3	424	c.30G>A	c.(28-30)acG>acA	p.T10T	PPP6R2_ENST00000395741.3_Silent_p.T10T|PPP6R2_ENST00000395744.3_Silent_p.T10T|PPP6R2_ENST00000216061.5_Silent_p.T10T	NM_001242898.1|NM_001242899.1|NM_001242900.1|NM_014678.4	NP_001229827.1|NP_001229828.1|NP_001229829.1|NP_055493.2	O75170	PP6R2_HUMAN	protein phosphatase 6, regulatory subunit 2	10						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	22						TGAACACCACGTCCCATGTTG	0.527000													41	97					0	0	1	0	0
TXLNA	200081	broad.mit.edu	37	1	32660568	32660568	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32660568C>T	ENST00000373609.1	+	10	1694	c.1413C>T	c.(1411-1413)tgC>tgT	p.C471C	TXLNA_ENST00000373610.3_Silent_p.C471C			P40222	TXLNA_HUMAN	taxilin alpha	471					cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				AGAAGCTGTGCCGGGCACTGC	0.577000													6	56					0	0	1	0	0
RAET1G	353091	broad.mit.edu	37	6	150239453	150239453	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:150239453G>A	ENST00000367360.2	-	4	766	c.699C>T	c.(697-699)tgC>tgT	p.C233C	RP11-244K5.1_ENST00000605899.1_RNA|RP11-244K5.8_ENST00000606915.1_RNA|RP11-244K5.1_ENST00000446954.1_RNA	NM_001001788.2	NP_001001788.2	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G	233					antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|urinary_tract(1)	13		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		TGATGAGGAGGCAGCAAAGGA	0.597000													12	29					0	0	1	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54706457	54706457	+	Splice_Site	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:54706457T>A	ENST00000230640.5	+	23	3005	c.2751_splice	c.e23+1	p.N917_splice	SKIV2L2_ENST00000545714.1_Splice_Site_p.N816_splice	NM_015360.4	NP_056175.3	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	917					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TTCAAGAGAATGTAAGTTAAT	0.303000													5	66					0	0	1	0	0
ASB16	92591	broad.mit.edu	37	17	42248207	42248207	+	Missense_Mutation	SNP	G	G	A	rs144140141		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42248207G>A	ENST00000293414.1	+	1	134	c.50G>A	c.(49-51)cGc>cAc	p.R17H		NM_080863.4	NP_543139.4	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box containing 16	17					intracellular signal transduction		protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|liver(2)|lung(2)|prostate(1)	14		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CGCTCTCTCCGCCTGCAGCAG	0.697000													15	17					0	0	1	0	0
IGLV7-46	0	broad.mit.edu	37	22	22724400	22724400	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:22724400C>T	ENST00000390295.2	+	0	330																											CTTTTGGGTGCGCAGCCTGAG	0.542000													12	17					0	0	1	0	0
CD28	940	broad.mit.edu	37	2	204591557	204591557	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:204591557A>G	ENST00000324106.7	+	2	403	c.254A>G	c.(253-255)aAc>aGc	p.N85S	CD28_ENST00000458610.2_Missense_Mutation_p.N99S|CD28_ENST00000374478.4_Intron|CD28_ENST00000374481.3_Intron	NM_006139.3	NP_006130.1	P10747	CD28_HUMAN	CD28 molecule	85	Ig-like V-type.				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13						ACGGGGTTCAACTGTGATGGG	0.408000													29	42					0	0	1	0	0
MLLT10	8028	broad.mit.edu	37	10	21959520	21959520	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:21959520C>T	ENST00000377072.3	+	10	1286	c.938C>T	c.(937-939)tCa>tTa	p.S313L	MLLT10_ENST00000307729.7_Missense_Mutation_p.S313L|MLLT10_ENST00000446906.2_Missense_Mutation_p.S313L|MLLT10_ENST00000377059.3_Missense_Mutation_p.S313L	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	313	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						ACTAGAGGGTCAGAGGGCAAA	0.473000			T	"""MLL, PICALM, CDK6"""	AL								18	32					0	0	1	0	0
B3GNT8	374907	broad.mit.edu	37	19	41931655	41931655	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41931655G>A	ENST00000321702.2	-	3	1482	c.1029C>T	c.(1027-1029)gcC>gcT	p.A343A	CTC-435M10.6_ENST00000598887.1_RNA	NM_198540.2	NP_940942.1	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	343					poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity			cervix(1)|kidney(2)|large_intestine(1)|lung(5)|prostate(2)	11						CCAGGCCCAGGGCTCGGATGC	0.687000													17	22					0	0	1	0	0
NR4A2	0	broad.mit.edu	37	2	157186101	157186101	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:157186101C>T	ENST00000339562.4	-	3	960	c.598G>A	c.(598-600)Gtc>Atc	p.V200I	NR4A2_ENST00000409108.2_Missense_Mutation_p.V200I|NR4A2_ENST00000409572.1_Missense_Mutation_p.V200I|NR4A2_ENST00000429376.1_Missense_Mutation_p.V137I|NR4A2_ENST00000539077.1_Missense_Mutation_p.V211I|NR4A2_ENST00000426264.1_Missense_Mutation_p.V137I	NM_006186.3	NP_006177.1	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	200	Pro-rich.				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	40						TTCATGGGGACGTGCAGGGGC	0.667000													22	35					0	0	1	0	0
SLC30A3	7781	broad.mit.edu	37	2	27481120	27481120	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27481120C>T	ENST00000233535.4	-	3	685	c.333G>A	c.(331-333)gcG>gcA	p.A111A	SLC30A3_ENST00000447008.2_Silent_p.A106A	NM_003459.4	NP_003450.2	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter), member 3	111					regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|pancreas(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCCCACATCCGCCAGCAAGT	0.592000													9	11					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7568267	7568267	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:7568267C>T	ENST00000340209.4	+	2	458	c.161C>T	c.(160-162)gCg>gTg	p.A54V	RBFOX1_ENST00000436368.2_Missense_Mutation_p.A69V|RBFOX1_ENST00000553186.1_Missense_Mutation_p.A49V|RBFOX1_ENST00000355637.4_Missense_Mutation_p.A69V|RBFOX1_ENST00000535565.2_Missense_Mutation_p.A85V|RBFOX1_ENST00000552089.1_Missense_Mutation_p.A85V|RBFOX1_ENST00000311745.5_Missense_Mutation_p.A69V|RBFOX1_ENST00000547372.1_Missense_Mutation_p.A92V|RBFOX1_ENST00000550418.1_Missense_Mutation_p.A49V|RBFOX1_ENST00000422070.4_Missense_Mutation_p.A92V|RBFOX1_ENST00000547338.1_Missense_Mutation_p.A49V			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	49					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						CCCCACCCCGCGCCAGAGTAC	0.657000													6	92					0	0	1	0	0
ZDHHC7	55625	broad.mit.edu	37	16	85015549	85015549	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:85015549G>A	ENST00000313732.4	-	4	719	c.367C>T	c.(367-369)Ctg>Ttg	p.L123L	ZDHHC7_ENST00000569488.1_Intron|ZDHHC7_ENST00000564466.1_Silent_p.L160L	NM_017740.2	NP_060210.2	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7	123						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(6)|lung(4)	10						CCGGGCTTCAGCTGCAAGCTC	0.493000													47	74					0	0	1	0	0
CD28	940	broad.mit.edu	37	2	204591691	204591691	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:204591691G>T	ENST00000374481.3	+	3	358	c.136G>T	c.(136-138)Gga>Tga	p.G46*	CD28_ENST00000458610.2_Nonsense_Mutation_p.G144*|CD28_ENST00000374478.4_Intron|CD28_ENST00000324106.7_Nonsense_Mutation_p.G130*			P10747	CD28_HUMAN	CD28 molecule	130	Ig-like V-type.				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13						GAAGAGCAATGGAACCATTAT	0.373000													17	26					6.94344e-10	7.39541e-10	1	1	0
LRRC37A2	474170	broad.mit.edu	37	17	44626192	44626192	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:44626192C>T	ENST00000576629.1	+	10	4182	c.3687C>T	c.(3685-3687)aaC>aaT	p.N1229N	ARL17A_ENST00000329240.4_Intron|ARL17A_ENST00000573185.1_Intron|ARL17A_ENST00000337845.7_Intron|ARL17A_ENST00000445552.2_Intron|LRRC37A2_ENST00000333412.3_Silent_p.N1229N			A6NM11	L37A2_HUMAN	leucine rich repeat containing 37, member A2	1229						integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|pancreas(4)|prostate(2)	15		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		TAGCGGGAAACGCCGTCTACA	0.592000													4	128					0	0	1	0	0
TLR1	7096	broad.mit.edu	37	4	38798902	38798902	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:38798902C>T	ENST00000308979.2	-	4	1824	c.1551G>A	c.(1549-1551)agG>agA	p.R517R	TLR1_ENST00000502213.2_Silent_p.R517R	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	517					cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						CTTTTATTGACCTCATCTTCT	0.443000													81	113					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128896335	128896335	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128896335G>T	ENST00000375990.3	+	16	1959	c.1556G>T	c.(1555-1557)gGg>gTg	p.G519V	UGGT1_ENST00000259253.6_Missense_Mutation_p.G543V			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	543					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						GATGTTGATGGGATGCAAGAT	0.378000													43	69					1.62957e-23	1.81649e-23	1	1	0
MIS18BP1	55320	broad.mit.edu	37	14	45687566	45687566	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:45687566T>C	ENST00000310806.4	-	12	3219	c.2761A>G	c.(2761-2763)Aaa>Gaa	p.K921E		NM_018353.4	NP_060823.3	Q6P0N0	M18BP_HUMAN	MIS18 binding protein 1	921	SANT.				cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	39						TCCATGTATTTCCTCTGGCAT	0.448000													56	65					0	0	1	0	0
SLC25A2	83884	broad.mit.edu	37	5	140683225	140683225	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140683225C>T	ENST00000239451.4	-	1	387	c.208G>A	c.(208-210)Gca>Aca	p.A70T		NM_031947.2	NP_114153.1	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2	70					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	GCCATAAGTGCCGGGCCGGTG	0.577000													38	32					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36168828	36168828	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:36168828C>T	ENST00000357641.6	+	2	982	c.729C>T	c.(727-729)tgC>tgT	p.C243C	BRPF3_ENST00000534400.1_Silent_p.C243C|BRPF3_ENST00000543502.1_Silent_p.C243C|BRPF3_ENST00000339717.7_Silent_p.C243C|BRPF3_ENST00000443324.2_Silent_p.C243C|BRPF3_ENST00000534694.1_Silent_p.C243C	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	243					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						ACCAGGAGTGCTATGGCGTCC	0.537000													14	26					0	0	1	0	0
LYPD3	27076	broad.mit.edu	37	19	43965686	43965686	+	Silent	SNP	G	G	A	rs34879346		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:43965686G>A	ENST00000244333.3	-	5	946	c.858C>T	c.(856-858)caC>caT	p.H286H		NM_014400.2	NP_055215.2	O95274	LYPD3_HUMAN	LY6/PLAUR domain containing 3	286						anchored to plasma membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|upper_aerodigestive_tract(2)	11		Prostate(69;0.0153)				GGGAGGCCTCGTGTTCTACTC	0.632000													24	33					0	0	1	0	0
BACE2	25825	broad.mit.edu	37	21	42622768	42622768	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:42622768C>T	ENST00000330333.6	+	7	1537	c.1074C>T	c.(1072-1074)atC>atT	p.I358I	BACE2_ENST00000466122.1_3'UTR|BACE2_ENST00000328735.6_Silent_p.I358I|BACE2_ENST00000347667.4_Intron	NM_012105.3	NP_036237.2	Q9Y5Z0	BACE2_HUMAN	beta-site APP-cleaving enzyme 2	358					membrane protein ectodomain proteolysis|negative regulation of amyloid precursor protein biosynthetic process|peptide hormone processing	cell surface|endoplasmic reticulum|endosome|Golgi apparatus|integral to membrane	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Prostate(19;1.57e-07)|all_epithelial(19;0.0251)				TCCCTAAAATCTCCATCTACC	0.463000													31	17					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48617238	48617238	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48617238C>A	ENST00000328333.8	-	57	5241	c.5134G>T	c.(5134-5136)Gga>Tga	p.G1712*	COL7A1_ENST00000454817.1_Nonsense_Mutation_p.G1712*	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1712	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity	p.G1712R(1)		NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCTCCAGGTCCTGTGTCTACC	0.577000													29	35					4.74835e-14	5.17254e-14	1	1	0
BARD1	580	broad.mit.edu	37	2	215645655	215645655	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:215645655G>A	ENST00000260947.4	-	4	1077	c.943C>T	c.(943-945)Cca>Tca	p.P315S	BARD1_ENST00000471787.1_5'UTR|BARD1_ENST00000449967.2_Missense_Mutation_p.P171S	NM_000465.2	NP_000456.2	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	315					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(2)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|prostate(4)|upper_aerodigestive_tract(1)	35		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTTTCTAATGGCAAAGATTTC	0.398000									Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				31	74					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984361	85984361	+	Missense_Mutation	SNP	C	C	T	rs151197977		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:85984361C>T	ENST00000372113.4	-	2	625	c.620G>A	c.(619-621)cGc>cAc	p.R207H	LRIT2_ENST00000538192.1_Missense_Mutation_p.R207H	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	207	LRRCT.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						CCCCCTTAGGCGACAGTCACA	0.582000													11	20					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12906105	12906105	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:12906105C>T	ENST00000380659.3	+	3	2617	c.2478C>T	c.(2476-2478)atC>atT	p.I826I		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	826					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	AAAGTGTGATCTCCCTGGATC	0.478000													40	14					0	0	1	0	0
NPFF	8620	broad.mit.edu	37	12	53900561	53900561	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53900561C>T	ENST00000267017.3	-	3	504	c.341G>A	c.(340-342)tGa>tAa	p.*114*	RP11-793H13.10_ENST00000591834.1_3'UTR	NM_003717.2	NP_003708.1	O15130	NPFF_HUMAN	neuropeptide FF-amide peptide precursor	0					neuropeptide signaling pathway|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity			haematopoietic_and_lymphoid_tissue(1)|prostate(1)|urinary_tract(1)	3						GATGACATGTCACTTCTTCCC	0.522000													13	57					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	534269	534269	+	Silent	SNP	C	C	T	rs148380285		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:534269C>T	ENST00000417302.1	-	2	241	c.54G>A	c.(52-54)gcG>gcA	p.A18A	HRAS_ENST00000451590.1_Silent_p.A18A|HRAS_ENST00000397596.2_Silent_p.A18A|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000397594.1_Silent_p.A18A|HRAS_ENST00000311189.7_Silent_p.A18A	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	18					activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GGATGGTCAGCGCACTCTTGC	0.647000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			4	41					0	0	1	0	0
TCEA3	6920	broad.mit.edu	37	1	23735189	23735189	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:23735189G>T	ENST00000450454.2	-	5	517	c.411C>A	c.(409-411)gcC>gcA	p.A137A	TCEA3_ENST00000461794.1_Silent_p.A100A|TCEA3_ENST00000374601.3_Silent_p.A137A	NM_003196.1	NP_003187.1	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	137	Ser-rich.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		GAGAGGAGGAGGCAGAAGACT	0.478000													6	9					0.00116845	0.0011864	1	1	0
TCP11L1	55346	broad.mit.edu	37	11	33080601	33080601	+	Silent	SNP	C	C	T	rs77360478	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:33080601C>T	ENST00000334274.4	+	6	1135	c.735C>T	c.(733-735)taC>taT	p.Y245Y	TCP11L1_ENST00000432887.1_Silent_p.Y245Y|TCP11L1_ENST00000531632.2_Silent_p.Y245Y|TCP11L1_ENST00000324357.9_Silent_p.Y24Y	NM_018393.3	NP_060863.3	Q9NUJ3	T11L1_HUMAN	t-complex 11, testis-specific-like 1	245										kidney(1)|liver(2)|lung(2)|skin(1)	6						CAGTTGAATACGAAAGGAAGA	0.388000													35	54					0	0	1	0	0
GGCX	2677	broad.mit.edu	37	2	85778163	85778163	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:85778163C>T	ENST00000233838.3	-	13	1853	c.1773G>A	c.(1771-1773)acG>acA	p.T591T	GGCX_ENST00000430215.3_Silent_p.T534T	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase	591					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	TAGGTGATGTCGTATACACCT	0.453000													26	43					0	0	1	0	0
AP5Z1	9907	broad.mit.edu	37	7	4830482	4830482	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:4830482C>T	ENST00000348624.4	+	16	2211	c.2117C>T	c.(2116-2118)aCg>aTg	p.T706M	AP5Z1_ENST00000490487.1_3'UTR	NM_014855.2	NP_055670.1	O43299	K0415_HUMAN	adaptor-related protein complex 5, zeta 1 subunit	706					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										ACCACGCTGACGAAGCTGGCC	0.662000													12	9					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14030737	14030737	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:14030737G>T	ENST00000318003.7	+	12	1570	c.1329G>T	c.(1327-1329)gaG>gaT	p.E443D	CC2D1A_ENST00000589606.1_Missense_Mutation_p.E443D	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	443					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			AAGGCCCAGAGGATGAAGAGG	0.607000													10	13					7.48243e-07	7.8103e-07	1	1	0
CCDC144A	9720	broad.mit.edu	37	17	16593939	16593939	+	Silent	SNP	C	C	T	rs2621675		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:16593939C>T	ENST00000443444.2	+	1	365	c.225C>T	c.(223-225)gaC>gaT	p.D75D	CCDC144A_ENST00000436374.1_3'UTR|CCDC144A_ENST00000360524.8_Silent_p.D75D|RP11-219A15.1_ENST00000448331.3_Silent_p.D75D|CCDC144A_ENST00000456009.1_Silent_p.D75D|CCDC144A_ENST00000340621.5_Silent_p.D75D|CCDC144A_ENST00000399273.1_Silent_p.D75D			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	75																	CCCAGCACGACGTCCGCCTGG	0.652000													37	58					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131602982	131602982	+	Silent	SNP	C	C	T	rs148299008		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:131602982C>T	ENST00000261654.5	+	19	2653	c.2094C>T	c.(2092-2094)taC>taT	p.Y698Y	GPR133_ENST00000543617.1_Silent_p.Y217Y|GPR133_ENST00000376682.4_Silent_p.Y384Y|GPR133_ENST00000535015.1_Silent_p.Y730Y	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	698					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGGACAGTTACGGAACAAGCA	0.493000													7	148					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46821804	46821804	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:46821804C>T	ENST00000283296.7	-	21	4254	c.3966G>A	c.(3964-3966)acG>acA	p.T1322T	GPR116_ENST00000545669.1_3'UTR|GPR116_ENST00000265417.7_Silent_p.T1322T|GPR116_ENST00000456426.2_Silent_p.T1180T|GPR116_ENST00000362015.4_Silent_p.T1302T	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1322					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			AAACATTATACGTTCCTGAAA	0.493000													20	25					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99569532	99569532	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99569532G>T	ENST00000411734.1	-	2	170	c.165C>A	c.(163-165)ttC>ttA	p.F55L	AZGP1_ENST00000292401.4_Missense_Mutation_p.F58L			P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	58					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					TGTATCTAAAGAACTGGAGGT	0.512000													22	29					8.04996e-18	8.87193e-18	1	1	0
PCDHGA9	0	broad.mit.edu	37	5	140782757	140782757	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140782757C>T	ENST00000573521.1	+	1	238	c.238C>T	c.(238-240)Cgc>Tgc	p.R80C	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGAACCCGCGCAGCGGCAC	0.617000													34	45					0	0	1	0	0
AKT1S1	84335	broad.mit.edu	37	19	50374839	50374839	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50374839T>C	ENST00000391833.1	-	3	2581	c.592A>G	c.(592-594)Aca>Gca	p.T198A	AKT1S1_ENST00000391835.1_Missense_Mutation_p.T218A|AKT1S1_ENST00000391834.2_Missense_Mutation_p.T198A|AKT1S1_ENST00000344175.5_Missense_Mutation_p.T198A|AKT1S1_ENST00000391831.1_Missense_Mutation_p.T198A|AKT1S1_ENST00000391832.3_Missense_Mutation_p.T198A	NM_001278160.1	NP_001265089.1	Q96B36	AKTS1_HUMAN	AKT1 substrate 1 (proline-rich)	198					negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|nerve growth factor receptor signaling pathway|neuroprotection|phosphatidylinositol-mediated signaling|regulation of survival gene product expression	cytosolic part	protein binding			kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		CGCGCCTCTGTCCTCTTCTCC	0.647000													53	85					0	0	1	0	0
TRIM46	80128	broad.mit.edu	37	1	155156326	155156326	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155156326C>T	ENST00000368382.1	+	10	2008	c.1871C>T	c.(1870-1872)gCg>gTg	p.A624V	TRIM46_ENST00000392451.2_3'UTR|TRIM46_ENST00000334634.4_Missense_Mutation_p.A647V|TRIM46_ENST00000468878.1_3'UTR|TRIM46_ENST00000545012.1_Missense_Mutation_p.A521V	NM_001256599.1|NM_001256600.1|NM_001256601.1|NM_025058.4	NP_001243528.1|NP_001243529.1|NP_001243530.1|NP_079334.3	Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	647	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			ACAGTGGAGGCGTCGCCACCC	0.637000													20	38					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62848581	62848581	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:62848581G>A	ENST00000536311.1	+	11	2157	c.1793G>A	c.(1792-1794)cGc>cAc	p.R598H	MYT1_ENST00000328439.1_Missense_Mutation_p.R598H|MYT1_ENST00000360149.4_Missense_Mutation_p.R300H			Q01538	MYT1_HUMAN	myelin transcription factor 1	598					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R598H(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					TTTGGCAAACGCATGCTTGCC	0.512000													29	39					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24450058	24450058	+	Missense_Mutation	SNP	C	C	T	rs142854013	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:24450058C>T	ENST00000230036.1	-	15	1515	c.1405G>A	c.(1405-1407)Gtg>Atg	p.V469M		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	469						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						GGAGCTCCCACGGCCAGGTCA	0.617000													15	28					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47041142	47041142	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:47041142G>A	ENST00000383740.2	+	0	3905				NBEAL2_ENST00000292309.5_Intron|NBEAL2_ENST00000450053.3_Silent_p.L1242L			Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2								binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TCTCAGATCTGCTGGCTGTGG	0.617000													18	21					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167129367	167129367	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:167129367C>T	ENST00000303354.6	-	17	3236	c.2896G>A	c.(2896-2898)Gcc>Acc	p.A966T	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.A954T|SCN9A_ENST00000375387.4_Missense_Mutation_p.A966T|SCN9A_ENST00000409435.1_Missense_Mutation_p.A965T			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	965						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AATAATAAGGCCAGAAATAGG	0.378000													7	10					0	0	1	0	0
SLC27A1	376497	broad.mit.edu	37	19	17611139	17611139	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17611139G>A	ENST00000252595.7	+	8	1356	c.1259G>A	c.(1258-1260)cGg>cAg	p.R420Q	SLC27A1_ENST00000598848.1_3'UTR|SLC27A1_ENST00000442725.1_Missense_Mutation_p.R420Q|SLC27A1_ENST00000598424.1_Missense_Mutation_p.R241Q|CTD-3131K8.2_ENST00000596643.1_lincRNA	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	420	Sufficient for oligomerization (By similarity).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TACCCCATCCGGCTGGTGAAG	0.652000													26	33					0	0	1	0	0
WARS2	10352	broad.mit.edu	37	1	119584902	119584902	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:119584902T>C	ENST00000369426.5	-	4	503	c.500A>G	c.(499-501)gAc>gGc	p.D167G	WARS2_ENST00000235521.4_Missense_Mutation_p.D167G|WARS2_ENST00000537870.1_Missense_Mutation_p.D73G			Q9UGM6	SYWM_HUMAN	tryptophanyl tRNA synthetase 2, mitochondrial	167					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(2)	15	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	CAACAGAATGTCGGCTGCCTG	0.478000													28	44					0	0	1	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171424	68171424	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:68171424C>T	ENST00000243457.3	+	2	627	c.244C>T	c.(244-246)Cgg>Tgg	p.R82W	KCNJ2_ENST00000535240.1_Missense_Mutation_p.R82W	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	82					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					CATTCGCTGGCGGTGGATGCT	0.517000													30	35					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169642042	169642042	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:169642042C>T	ENST00000366787.3	-	6	955	c.706G>A	c.(706-708)Gcc>Acc	p.A236T		NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	236					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TCACTGATGGCGTTGATCTCA	0.657000													16	20					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154379709	154379709	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:154379709G>A	ENST00000406326.1	+	6	1380	c.977G>A	c.(976-978)gGc>gAc	p.G326D	DPP6_ENST00000332007.3_Intron|DPP6_ENST00000427557.1_Intron|DPP6_ENST00000404039.1_Intron|DPP6_ENST00000377770.3_Intron			P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	0					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity	p.G326V(1)		NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TACGAGTGTGGCAGGTGTGAG	0.607000													23	45					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90426431	90426431	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:90426431G>A	ENST00000369393.3	-	44	6796	c.6681C>T	c.(6679-6681)agC>agT	p.S2227S	MDN1_ENST00000428876.1_Silent_p.S2227S			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	2227					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GAACCAACATGCTGTCAACCC	0.468000													6	67					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75683619	75683619	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:75683619C>T	ENST00000370855.5	-	18	1669	c.1556G>A	c.(1555-1557)gGa>gAa	p.G519E	SLC44A5_ENST00000370859.3_Missense_Mutation_p.G519E|SLC44A5_ENST00000535611.1_Missense_Mutation_p.G389E	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	519						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						AATTAAAGATCCAAATGCTAG	0.294000													23	33					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44013447	44013447	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:44013447G>A	ENST00000269439.7	+	2	407	c.356G>A	c.(355-357)cGc>cAc	p.R119H	RNF165_ENST00000543885.1_Intron	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	119							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		GCCCAGCACCGCAGGCTGGTC	0.701000													7	12					0	0	1	0	0
KIAA0930	23313	broad.mit.edu	37	22	45601700	45601700	+	Missense_Mutation	SNP	C	C	T	rs146302383		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:45601700C>T	ENST00000336156.4	-	3	375	c.310G>A	c.(310-312)Gtc>Atc	p.V104I	KIAA0930_ENST00000391627.2_Missense_Mutation_p.V70I|KIAA0930_ENST00000251993.7_Missense_Mutation_p.V109I|KIAA0930_ENST00000443310.3_Missense_Mutation_p.V86I	NM_001009880.1	NP_001009880.1	Q6ICG6	K0930_HUMAN	KIAA0930	104							protein binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|urinary_tract(1)	15						TTCAGGCAGACGCTCTCCTCC	0.652000													4	16					0	0	1	0	0
GNAZ	2781	broad.mit.edu	37	22	23465564	23465564	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:23465564C>T	ENST00000248996.4	+	3	1680	c.1014C>T	c.(1012-1014)gaC>gaT	p.D338D	RTDR1_ENST00000216036.4_Intron	NM_002073.2	NP_002064.1	P19086	GNAZ_HUMAN	guanine nucleotide binding protein (G protein), alpha z polypeptide	338						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(5)|urinary_tract(1)	19	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		TTGTCTTCGACGCGGTGACAG	0.562000													13	18					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149264056	149264056	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149264056G>A	ENST00000255266.5	-	16	2132	c.2013C>T	c.(2011-2013)ctC>ctT	p.L671L		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	671					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AATACAGGGCGAGGTCTGTGG	0.338000													25	27					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24860352	24860352	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:24860352C>T	ENST00000424834.2	+	8	2775	c.2301_splice	c.e8-1	p.L768_splice	SPATA13_ENST00000382108.3_Splice_Site_p.L768_splice|SPATA13_ENST00000399949.2_Splice_Site_p.L65_splice|SPATA13_ENST00000382095.4_Splice_Site_p.L143_splice|SPATA13_ENST00000409126.1_Splice_Site_p.L65_splice|SPATA13_ENST00000343003.6_Splice_Site_p.L87_splice			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	143					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		CTCCTTTCAGCTGATCAGTGA	0.587000													34	84					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34006739	34006739	+	Missense_Mutation	SNP	C	C	T	rs139840174		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:34006739C>T	ENST00000373381.4	-	59	9624	c.9448G>A	c.(9448-9450)Gtc>Atc	p.V3150I		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3122	Sushi 25.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCTTTGCAGACGGGCTTGGTT	0.507000													33	60					0	0	1	0	0
SNHG14	0	broad.mit.edu	37	15	25339071	25339071	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:25339071G>T	ENST00000546682.1	+	0	1060				SNHG14_ENST00000553108.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						CTGGGCACGTGCAGCATATGT	0.507000													5	13					0.014758	0.0148771	1	1	0
APLP1	333	broad.mit.edu	37	19	36365707	36365707	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36365707C>T	ENST00000221891.4	+	10	1472	c.1280C>T	c.(1279-1281)aCg>aTg	p.T427M	APLP1_ENST00000537454.2_Missense_Mutation_p.T388M|APLP1_ENST00000586861.1_Missense_Mutation_p.T421M|APLP1_ENST00000589298.2_3'UTR	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	427	Heparin-binding (By similarity).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAGAGGCACACGCTGCGCCAC	0.652000													15	16					0	0	1	0	0
CMC1	152100	broad.mit.edu	37	3	28304845	28304845	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:28304845A>C	ENST00000466830.1	+	2	282	c.83A>C	c.(82-84)aAa>aCa	p.K28T	CMC1_ENST00000423894.1_Intron	NM_182523.1	NP_872329.1	Q7Z7K0	COXAM_HUMAN	C-x(9)-C motif containing 1	28						mitochondrion	metal ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)	5						GAAAAGGCCAAAGAGAGGTGT	0.303000													20	36					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21571562	21571562	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:21571562G>A	ENST00000415912.2	-	10	1275	c.1150C>T	c.(1150-1152)Cgg>Tgg	p.R384W	ECE1_ENST00000374893.6_Missense_Mutation_p.R400W|ECE1_ENST00000264205.6_Missense_Mutation_p.R397W|ECE1_ENST00000357071.4_Missense_Mutation_p.R388W|ECE1_ENST00000528294.1_5'UTR|ECE1_ENST00000436918.2_Missense_Mutation_p.R400W	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	400					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity	p.R400W(1)		endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		CTTGTTTTCCGCACCAGGTTC	0.572000											OREG0013200	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	23					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9066185	9066185	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9066185A>G	ENST00000397910.4	-	3	21464	c.21261T>C	c.(21259-21261)tcT>tcC	p.S7087S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7089	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCAGAGAGGGAGAGCTTTGCC	0.502000													8	28					0	0	1	0	0
PLK4	0	broad.mit.edu	37	4	128807514	128807514	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:128807514G>A	ENST00000270861.5	+	5	1263	c.989G>A	c.(988-990)aGt>aAt	p.S330N	PLK4_ENST00000507249.1_Missense_Mutation_p.S330N|PLK4_ENST00000515069.1_Missense_Mutation_p.S330N|PLK4_ENST00000513090.1_Missense_Mutation_p.S298N|PLK4_ENST00000514379.1_Missense_Mutation_p.S289N	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	330					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						AAGAATAAAAGTTCAACTGAT	0.348000													20	31					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113388746	113388746	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:113388746G>A	ENST00000228928.7	+	7	1802	c.1623G>A	c.(1621-1623)acG>acA	p.T541T	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	541	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						AGAGCTGGACGGATGTTAGCC	0.622000													11	18					0	0	1	0	0
C17orf98	388381	broad.mit.edu	37	17	36997589	36997589	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36997589G>A	ENST00000398575.4	-	1	119	c.54C>T	c.(52-54)gaC>gaT	p.D18D		NM_001080465.2	NP_001073934.1	A8MV24	CQ098_HUMAN	chromosome 17 open reading frame 98	18										endometrium(5)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(3)	14						CAGCCACCCCGTCCAAGATAA	0.647000													13	13					0	0	1	0	0
ZNF92	168374	broad.mit.edu	37	7	64864737	64864737	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:64864737C>T	ENST00000328747.7	+	4	1909	c.1710C>T	c.(1708-1710)ggC>ggT	p.G570G	ZNF92_ENST00000431504.1_Silent_p.G494G|ZNF92_ENST00000357512.2_Silent_p.G538G|ZNF92_ENST00000450302.2_Silent_p.G501G	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	570						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				ATGAATGTGGCAGAGCCTTTA	0.328000													26	51					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85738568	85738568	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:85738568G>A	ENST00000322366.6	-	13	2271	c.1864C>T	c.(1864-1866)Cag>Tag	p.Q622*	WDFY3_ENST00000295888.4_Nonsense_Mutation_p.Q622*			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	622						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GTCTTCAACTGCAATTCCGTC	0.418000													6	130					0	0	1	0	0
DHFR	1719	broad.mit.edu	37	5	79924946	79924946	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:79924946C>T	ENST00000439211.2	-	6	1017	c.524G>A	c.(523-525)gGc>gAc	p.G175D	DHFR_ENST00000511032.1_3'UTR|DHFR_ENST00000505337.1_Missense_Mutation_p.G175D|DHFR_ENST00000513048.1_5'UTR|DHFR_ENST00000504396.1_Missense_Mutation_p.G123D	NM_000791.3	NP_000782.1	P00374	DYR_HUMAN	dihydrofolate reductase	175	DHFR.				folic acid metabolic process|glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to methotrexate|tetrahydrofolate metabolic process	cytosol	dihydrofolate reductase activity|drug binding|folate reductase activity|NADP binding			kidney(1)|large_intestine(1)	2		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.69e-46)|Epithelial(54;7.49e-41)|all cancers(79;1.54e-35)	Dapsone(DB00250)|Dimethyl sulfoxide(DB01093)|Lamotrigine(DB00555)|Methotrexate(DB00563)|NADH(DB00157)|Pemetrexed(DB00642)|Proguanil(DB01131)|Pyrimethamine(DB00205)|Trimethoprim(DB00440)|Trimetrexate(DB01157)	GTACTTAATGCCTTTCTCCTC	0.328000													10	15					0	0	1	0	0
RPL34	6164	broad.mit.edu	37	4	109543161	109543161	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:109543161G>A	ENST00000394668.2	+	2	112	c.46G>A	c.(46-48)Gcc>Acc	p.A16T	RPL34_ENST00000502534.1_Missense_Mutation_p.A16T|RPL34_ENST00000394665.1_Missense_Mutation_p.A16T|RPL34_ENST00000506397.1_Missense_Mutation_p.A16T|RPL34_ENST00000394667.3_Missense_Mutation_p.A16T	NM_033625.2	NP_296374.1	P49207	RL34_HUMAN	ribosomal protein L34	16					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			kidney(2)|lung(1)|upper_aerodigestive_tract(1)	4		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000286)		CTACAATACAGCCTCTAACAA	0.348000													20	87					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31659444	31659444	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31659444C>T	ENST00000375842.4	-	9	1084	c.98G>A	c.(97-99)cGg>cAg	p.R33Q	ABHD16A_ENST00000440843.2_Missense_Mutation_p.R219Q|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000395952.3_Missense_Mutation_p.R252Q			O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	252						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						CAGCTTTGCCCGGCGCCCATT	0.627000													10	13					0	0	1	0	0
PFKP	5214	broad.mit.edu	37	10	3124650	3124650	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:3124650C>T	ENST00000381075.2	+	3	303	c.79C>T	c.(79-81)Cga>Tga	p.R27*	PFKP_ENST00000381125.4_Silent_p.Y61Y	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	0					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		ACTTCATCTACGAGGTCAGTG	0.632000													14	34					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3643784	3643784	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:3643784C>T	ENST00000378295.4	+	7	993	c.838C>T	c.(838-840)Cgg>Tgg	p.R280W	TP73_ENST00000603362.1_Missense_Mutation_p.R280W|TP73_ENST00000378290.4_Missense_Mutation_p.R209W|TP73_ENST00000378288.4_Missense_Mutation_p.R231W|TP73_ENST00000357733.3_Missense_Mutation_p.R280W|TP73_ENST00000354437.4_Missense_Mutation_p.R280W|TP73_ENST00000346387.4_Missense_Mutation_p.R280W|TP73_ENST00000604479.1_Missense_Mutation_p.R280W|TP73_ENST00000378280.1_Missense_Mutation_p.R231W|TP73_ENST00000378285.1_Missense_Mutation_p.R231W|TP73_ENST00000604074.1_Missense_Mutation_p.R280W	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	280	DNA-binding (Potential).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		CCTGGAGATGCGGGAGTGAGT	0.627000													13	19					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168107609	168107609	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:168107609C>A	ENST00000409195.1	+	9	9796	c.9707C>A	c.(9706-9708)cCt>cAt	p.P3236H	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.P3236H|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.P3014H|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3061					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GACTCTCCACCTACAATCACA	0.438000													4	50					0.150653	0.151081	1	1	0
PARP8	79668	broad.mit.edu	37	5	50137867	50137867	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:50137867C>A	ENST00000281631.5	+	26	2688	c.2530C>A	c.(2530-2532)Ctc>Atc	p.L844I	PARP8_ENST00000505554.1_Missense_Mutation_p.L823I|PARP8_ENST00000503750.2_Missense_Mutation_p.L802I|PARP8_ENST00000505697.2_Missense_Mutation_p.L844I|PARP8_ENST00000514067.2_Missense_Mutation_p.L802I|PARP8_ENST00000511363.2_3'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	844	PARP catalytic.					intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				CAAAGAGATCCTCCGAGTAAT	0.368000													25	43					1.66031e-10	1.77558e-10	1	1	0
MPP6	51678	broad.mit.edu	37	7	24705640	24705640	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:24705640G>A	ENST00000396475.2	+	9	1183	c.883_splice	c.e9-1	p.G295_splice	MPP6_ENST00000222644.4_Splice_Site_p.G295_splice|MPP6_ENST00000409761.1_Splice_Site_p.G183_splice	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	295					protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						CATCCTTCAGGACCTTTTTGT	0.328000													31	42					0	0	1	0	0
ATP11C	286410	broad.mit.edu	37	X	138820132	138820132	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:138820132G>A	ENST00000370557.1	-	28	4249	c.3222C>T	c.(3220-3222)agC>agT	p.S1074S	ATP11C_ENST00000361648.2_Silent_p.S1080S|ATP11C_ENST00000359686.2_Silent_p.S1080S|ATP11C_ENST00000460773.1_5'UTR|ATP11C_ENST00000370543.1_Silent_p.S1080S|ATP11C_ENST00000327569.3_Silent_p.S1080S			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	1080					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					CAGGGAACAGGCTGATAAATA	0.378000													14	44					0	0	1	0	0
CCDC120	90060	broad.mit.edu	37	X	48924841	48924841	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:48924841G>T	ENST00000376396.3	+	10	1305	c.1086G>T	c.(1084-1086)gaG>gaT	p.E362D	CCDC120_ENST00000597275.1_Missense_Mutation_p.E362D|CCDC120_ENST00000603986.1_Missense_Mutation_p.E397D|CCDC120_ENST00000536628.2_Missense_Mutation_p.E350D|CCDC120_ENST00000496529.2_Missense_Mutation_p.E362D|CCDC120_ENST00000422185.2_Missense_Mutation_p.E362D	NM_001271835.1|NM_001271836.1|NM_033626.2	NP_001258764.1|NP_001258765.1|NP_296375.1	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120	362							protein binding			breast(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14						ACAGTTCTGAGGCCCTGCTGG	0.721000													4	4					0.217242	0.217582	1	1	0
RELN	5649	broad.mit.edu	37	7	103244918	103244918	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:103244918G>A	ENST00000424685.2	-	23	3180	c.3021C>T	c.(3019-3021)acC>acT	p.T1007T	RELN_ENST00000343529.5_Silent_p.T1007T|RELN_ENST00000428762.1_Silent_p.T1007T			P78509	RELN_HUMAN	reelin	1007					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGCGGAAACGGGTAGCACTGG	0.483000													24	29					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48693726	48693726	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48693726C>T	ENST00000352832.5	+	26	5272	c.4900C>T	c.(4900-4902)Cgt>Tgt	p.R1634C	CACNA1G_ENST00000513689.2_Missense_Mutation_p.R1623C|CACNA1G_ENST00000507510.2_Missense_Mutation_p.R1668C|CACNA1G_ENST00000512389.1_Missense_Mutation_p.R1657C|CACNA1G_ENST00000514079.1_Missense_Mutation_p.R1675C|CACNA1G_ENST00000510115.1_Missense_Mutation_p.R1634C|CACNA1G_ENST00000510366.1_Missense_Mutation_p.R1616C|CACNA1G_ENST00000515411.1_Missense_Mutation_p.R1650C|CACNA1G_ENST00000515765.1_Missense_Mutation_p.R1657C|CACNA1G_ENST00000507896.1_Missense_Mutation_p.R1657C|CACNA1G_ENST00000503485.1_Missense_Mutation_p.R1634C|CACNA1G_ENST00000358244.5_Missense_Mutation_p.R1634C|CACNA1G_ENST00000513964.1_Missense_Mutation_p.R1623C|CACNA1G_ENST00000505165.1_Missense_Mutation_p.R1668C|CACNA1G_ENST00000515165.1_Missense_Mutation_p.R1668C|CACNA1G_ENST00000442258.2_Missense_Mutation_p.R1627C|CACNA1G_ENST00000360761.4_Missense_Mutation_p.R1645C|CACNA1G_ENST00000502264.1_Missense_Mutation_p.R1645C|CACNA1G_ENST00000514181.1_Missense_Mutation_p.R1650C|CACNA1G_ENST00000507336.1_Missense_Mutation_p.R1657C|CACNA1G_ENST00000507609.1_Missense_Mutation_p.R1668C|CACNA1G_ENST00000359106.5_Missense_Mutation_p.R1668C|CACNA1G_ENST00000514717.1_Missense_Mutation_p.R1611C|CACNA1G_ENST00000429973.2_Missense_Mutation_p.R1650C|CACNA1G_ENST00000354983.4_Missense_Mutation_p.R1634C	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1668					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CTTTGGTTTCCGTCGGTTCTT	0.488000													22	28					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161017764	161017764	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:161017764C>T	ENST00000368013.3	-	12	3367	c.3047G>A	c.(3046-3048)cGg>cAg	p.R1016Q	ARHGAP30_ENST00000368015.1_Missense_Mutation_p.R839Q|ARHGAP30_ENST00000368016.3_Missense_Mutation_p.R805Q	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	1016					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CTGGGTTCGCCGAACTCCTTG	0.587000													15	19					0	0	1	0	0
ZNF833P	0	broad.mit.edu	37	19	11762620	11762620	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11762620C>T	ENST00000344893.3	+	0	632					NR_028594.1															endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	5						GTGGATCATTCATCTCTGAAT	0.438000													4	16					0	0	1	0	0
CES2	8824	broad.mit.edu	37	16	66974233	66974233	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:66974233C>T	ENST00000317091.4	+	4	1708	c.724C>T	c.(724-726)Cgc>Tgc	p.R242C	CES2_ENST00000417689.1_Missense_Mutation_p.R242C	NM_003869.5	NP_003860.2	O00748	EST2_HUMAN	carboxylesterase 2	178					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CATCCAGTACCGCCTGGGTGT	0.607000													7	51					0	0	1	0	0
PTRF	284119	broad.mit.edu	37	17	40557039	40557039	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:40557039C>T	ENST00000357037.5	-	2	1258	c.839G>A	c.(838-840)cGc>cAc	p.R280H		NM_012232.5	NP_036364.2	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	280					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		GGGCACCAGGCGCGTGCCCAG	0.637000													21	28					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68940084	68940084	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:68940084G>A	ENST00000433211.1	-	7	1212	c.1038C>T	c.(1036-1038)taC>taT	p.Y346Y	CTNNA3_ENST00000373744.4_Silent_p.Y346Y|CTNNA3_ENST00000545309.1_Silent_p.Y346Y|CTNNA3_ENST00000494580.1_5'UTR	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	346					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						CGTTGTTCATGTACTCTGAAA	0.483000													12	17					0	0	1	0	0
CHPF2	54480	broad.mit.edu	37	7	150935155	150935155	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150935155G>T	ENST00000035307.2	+	4	3220	c.1707G>T	c.(1705-1707)gaG>gaT	p.E569D	CHPF2_ENST00000495645.1_Missense_Mutation_p.E561D	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	569						Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						TGCGAGCAGAGGCCCCTTCCC	0.627000													7	43					0.00307968	0.00311927	1	1	0
TET3	200424	broad.mit.edu	37	2	74327797	74327797	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74327797C>T	ENST00000409262.3	+	9	3477	c.3477C>T	c.(3475-3477)ccC>ccT	p.P1159P		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1159							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCAGCAACCCCGTCTTCCCCT	0.577000													11	22					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70009407	70009407	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:70009407C>T	ENST00000355303.5	+	19	2216	c.1911C>T	c.(1909-1911)ggC>ggT	p.G637G	ANO1_ENST00000398543.2_Silent_p.G491G|ANO1_ENST00000530676.1_Silent_p.G491G|ANO1_ENST00000531349.1_Silent_p.G346G|ANO1_ENST00000316296.5_Silent_p.G579G|ANO1_ENST00000538023.1_Silent_p.G637G	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	637					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						GACGCCCGGGCGACTACGTGT	0.527000													20	44					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110456103	110456103	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:110456103G>A	ENST00000378402.5	+	37	4867	c.4763G>A	c.(4762-4764)gGc>gAc	p.G1588D		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1588	IPT/TIG 8.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTGGACATGGCTTTAGTAAT	0.328000										HNSCC(38;0.096)			29	36					0	0	1	0	0
RP11-65J21.3	0	broad.mit.edu	37	16	14397837	14397837	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:14397837C>T	ENST00000570945.1	+	0	310				MIR193B_ENST00000384907.1_RNA																							GTCTCAGAATCGGGGTTTTGA	0.562000													56	96					0	0	1	0	0
ZWINT	0	broad.mit.edu	37	10	58119553	58119553	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:58119553G>A	ENST00000373944.3	-	4	356	c.318C>T	c.(316-318)caC>caT	p.H106H	ZWINT_ENST00000395405.1_Silent_p.H106H|ZWINT_ENST00000361148.6_Silent_p.H106H			O95229	ZWINT_HUMAN	ZW10 interacting kinetochore protein	106	Interaction with NDC80 and ZW10.				cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)	20						TGGCCTCTACGTGCTCCCTGT	0.542000													26	43					0	0	1	0	0
DLK2	65989	broad.mit.edu	37	6	43418543	43418543	+	Missense_Mutation	SNP	G	G	A	rs139041633		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43418543G>A	ENST00000357338.3	-	6	1586	c.886C>T	c.(886-888)Cgg>Tgg	p.R296W	DLK2_ENST00000414245.1_Missense_Mutation_p.R290W|DLK2_ENST00000372485.1_Missense_Mutation_p.R290W|DLK2_ENST00000372488.3_Missense_Mutation_p.R296W	NM_206539.1	NP_996262.1	Q6UY11	DLK2_HUMAN	delta-like 2 homolog (Drosophila)	296						integral to membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TCTTGCCTCCGCACCACCTCC	0.657000													20	30					0	0	1	0	0
FZD2	2535	broad.mit.edu	37	17	42636313	42636313	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:42636313G>A	ENST00000315323.3	+	1	1389	c.1257G>A	c.(1255-1257)ccG>ccA	p.P419P		NM_001466.3	NP_001457.1	Q14332	FZD2_HUMAN	frizzled family receptor 2	419					axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(8)	33		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGCTAGCGCCGCTCTTCGTGT	0.652000													4	75					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76388358	76388358	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:76388358A>T	ENST00000370014.3	+	15	2527	c.1908A>T	c.(1906-1908)gaA>gaT	p.E636D	SENP6_ENST00000370010.2_Missense_Mutation_p.E629D|SENP6_ENST00000447266.2_Missense_Mutation_p.E636D|SENP6_ENST00000327284.8_Missense_Mutation_p.E629D|SENP6_ENST00000541192.1_Missense_Mutation_p.E232D	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6	636					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				TTTTTGATGAAGAAGAAGAAA	0.313000													51	51					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180036931	180036931	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:180036931T>C	ENST00000261937.6	-	28	3859	c.3781A>G	c.(3781-3783)Acc>Gcc	p.T1261A	FLT4_ENST00000502649.1_Missense_Mutation_p.T1261A|FLT4_ENST00000393347.3_Missense_Mutation_p.T1261A	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1261					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GTCGTTGGGGTCATGGGGAAT	0.612000													30	37					0	0	1	0	0
CAMKK1	84254	broad.mit.edu	37	17	3783724	3783724	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3783724C>T	ENST00000381771.2	-	10	973	c.826G>A	c.(826-828)Gtc>Atc	p.V276I	CAMKK1_ENST00000381769.2_Missense_Mutation_p.V265I|CAMKK1_ENST00000348335.2_Missense_Mutation_p.V238I|CAMKK1_ENST00000158166.5_Missense_Mutation_p.V276I			Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase kinase 1, alpha	238	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	11				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		ACTTCCATGACGGGCCTATGG	0.632000													4	5					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	166020902	166020902	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166020902G>A	ENST00000360093.3	-	6	1093	c.602_splice	c.e6+1	p.A201_splice	SCN3A_ENST00000409101.3_Splice_Site_p.A201_splice|SCN3A_ENST00000283254.7_Splice_Site_p.A201_splice	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	201						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	AGTTACTCACGCCATCACAAT	0.358000													11	49					0	0	1	0	0
C5AR2	27202	broad.mit.edu	37	19	47844630	47844630	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47844630G>A	ENST00000595464.1	+	2	792	c.574G>A	c.(574-576)Ggc>Agc	p.G192S	C5AR2_ENST00000600626.1_Missense_Mutation_p.G192S|C5AR2_ENST00000257267.2_Missense_Mutation_p.G192S	NM_001271749.1	NP_001258678.1			complement component 5a receptor 2																		GGACTACGGCGGCTCCTCCAG	0.667000													21	37					0	0	1	0	0
CLK3	1198	broad.mit.edu	37	15	74914554	74914554	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:74914554C>T	ENST00000395066.3	+	4	1368	c.907C>T	c.(907-909)Cga>Tga	p.R303*	CLK3_ENST00000352989.5_Nonsense_Mutation_p.R155*|CLK3_ENST00000348245.3_Intron|CLK3_ENST00000345005.4_Nonsense_Mutation_p.R155*	NM_001130028.1	NP_001123500.1	P49761	CLK3_HUMAN	CDC-like kinase 3	303						acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)|stomach(2)|urinary_tract(1)	15						GCTCCAAGAGCGATGTACAGC	0.567000													14	15					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22737812	22737812	+	RNA	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:22737812A>G	ENST00000511446.1	+	0	270				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						ATGGGACGACAGGTTTCATCA	0.413000													48	43					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11000826	11000826	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:11000826C>T	ENST00000324288.8	+	11	1610	c.1477C>T	c.(1477-1479)Cgc>Tgc	p.R493C	CIITA_ENST00000537380.1_Intron|CIITA_ENST00000381835.5_Intron	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	493	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						GAGACCTGACCGCGTTCTGCT	0.642000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								38	53					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31475817	31475817	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31475817C>T	ENST00000457010.2	+	4	2174	c.1473C>T	c.(1471-1473)ccC>ccT	p.P491P	ARMC5_ENST00000538189.1_Silent_p.P523P|ARMC5_ENST00000268314.4_Silent_p.P491P|ARMC5_ENST00000412665.2_Silent_p.P135P|ARMC5_ENST00000408912.3_Silent_p.P586P|ARMC5_ENST00000563544.1_Silent_p.P491P	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	491							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CGGCCAGCCCCGCCCCGACCC	0.731000													6	10					0	0	1	0	0
LINC00518	0	broad.mit.edu	37	6	10430531	10430531	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:10430531C>T	ENST00000496285.1	-	0	504					NR_027793.1																						TTCCCAATGTCTGAGTGGCTC	0.398000													25	54					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66358114	66358114	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66358114C>A	ENST00000333861.3	-	1	2440	c.2373G>T	c.(2371-2373)gaG>gaT	p.E791D		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	791										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CAAAGATTAACTCTATCTCCT	0.522000													61	126					1.1362e-29	1.27275e-29	1	1	0
BOLA1	51027	broad.mit.edu	37	1	149871901	149871901	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:149871901C>T	ENST00000369153.2	+	3	953	c.289C>T	c.(289-291)Ctg>Ttg	p.L97L	BOLA1_ENST00000369150.1_Silent_p.L97L|BOLA1_ENST00000476344.1_3'UTR|BOLA1_ENST00000369152.5_Silent_p.L97L			Q9Y3E2	BOLA1_HUMAN	bolA family member 1	97						extracellular region	protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	10	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGCCGAGGAGCTGGGAGGTCC	0.662000													5	21					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6909344	6909344	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6909344C>A	ENST00000011653.4	+	2	298	c.40C>A	c.(40-42)Ctg>Atg	p.L14M	CD4_ENST00000541982.1_Missense_Mutation_p.L14M|CD4_ENST00000538827.1_Intron	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	14					cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				GCTTCTGGTGCTGCAACTGGG	0.592000													10	33					2.17888e-05	2.24846e-05	1	1	0
SPTBN1	0	broad.mit.edu	37	2	54848567	54848567	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:54848567C>T	ENST00000333896.5	+	7	1140	c.755C>T	c.(754-756)tCc>tTc	p.S252F	SPTBN1_ENST00000356805.4_Missense_Mutation_p.S265F	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	265	Actin-binding.|CH 2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GATGAGAAGTCCATAATCACT	0.458000													21	35					0	0	1	0	0
TMEM110	375346	broad.mit.edu	37	3	52883814	52883814	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52883814C>T	ENST00000355083.5	-	4	566	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	TMEM110-MUSTN1_ENST00000504329.1_Missense_Mutation_p.E141K	NM_198563.2	NP_940965.1			transmembrane protein 110											kidney(1)|large_intestine(1)|lung(2)	4				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)		TTACCATATTCGCCGAAGCGC	0.627000													5	9					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104069709	104069709	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104069709T>C	ENST00000388887.2	+	24	2760	c.2556T>C	c.(2554-2556)tgT>tgC	p.C852C		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	852	EGF-like 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TTTGCAGTTGTATTTGCAAAG	0.507000													22	31					0	0	1	0	0
EPS8L3	79574	broad.mit.edu	37	1	110299664	110299664	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110299664A>G	ENST00000369805.3	-	12	1325	c.1096T>C	c.(1096-1098)Ttg>Ctg	p.L366L	EPS8L3_ENST00000361852.4_Silent_p.L365L|EPS8L3_ENST00000361965.4_Silent_p.L365L|RP4-735C1.4_ENST00000431955.1_RNA	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	365						cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		GCTGGGCCCAACCCCATCCAA	0.582000													31	67					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113675464	113675464	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:113675464G>A	ENST00000003302.4	-	21	2657	c.2589C>T	c.(2587-2589)agC>agT	p.S863S	USP28_ENST00000260188.5_Silent_p.S831S|USP28_ENST00000545540.1_Silent_p.S706S|USP28_ENST00000544967.1_Silent_p.S539S	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	863					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		CCTTCATAATGCTGATTGATC	0.438000													25	52					0	0	1	0	0
PIGC	5279	broad.mit.edu	37	1	172411474	172411474	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:172411474A>G	ENST00000367728.1	-	1	1752	c.289T>C	c.(289-291)Tat>Cat	p.Y97H	PIGC_ENST00000258324.1_Missense_Mutation_p.Y97H|PIGC_ENST00000344529.4_Missense_Mutation_p.Y97H|PIGC_ENST00000484368.1_Intron|C1orf105_ENST00000367727.4_Intron			Q92535	PIGC_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class C	97					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			breast(1)|endometrium(1)|kidney(1)|lung(1)	4						AACAAAACATACCCAATCAGT	0.493000													11	24					0	0	1	0	0
ARCN1	372	broad.mit.edu	37	11	118461128	118461128	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118461128G>A	ENST00000359415.4	+	7	1179	c.1014G>A	c.(1012-1014)ttG>ttA	p.L338L	ARCN1_ENST00000392859.3_Silent_p.L209L|ARCN1_ENST00000264028.4_Silent_p.L297L|ARCN1_ENST00000534182.2_Intron			P48444	COPD_HUMAN	archain 1	297	MHD.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol				endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|urinary_tract(1)	13	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		ATATGGAGTTGCATGGCATGA	0.388000													4	79					0	0	1	0	0
BCS1L	617	broad.mit.edu	37	2	219526232	219526232	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219526232A>G	ENST00000431802.1	+	3	1123	c.424A>G	c.(424-426)Act>Gct	p.T142A	BCS1L_ENST00000439945.1_Missense_Mutation_p.T142A|BCS1L_ENST00000412366.1_Missense_Mutation_p.T142A|BCS1L_ENST00000392109.1_Missense_Mutation_p.T142A|BCS1L_ENST00000392110.2_Missense_Mutation_p.T142A|BCS1L_ENST00000392111.2_Missense_Mutation_p.T142A|BCS1L_ENST00000359273.3_Missense_Mutation_p.T142A			Q9Y276	BCS1_HUMAN	BC1 (ubiquinol-cytochrome c reductase) synthesis-like	142					mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	8		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCCCTGGGCACTGACCGAAA	0.532000													23	21					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39436200	39436200	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:39436200C>T	ENST00000257408.4	+	2	1293	c.1196C>T	c.(1195-1197)gCg>gTg	p.A399V		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	399	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						TTAAGAGAAGCGCTGAACTGG	0.428000													39	65					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112767612	112767612	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:112767612T>C	ENST00000295408.4	+	15	2305	c.2048T>C	c.(2047-2049)tTa>tCa	p.L683S	MERTK_ENST00000421804.2_Missense_Mutation_p.L683S|MERTK_ENST00000409780.1_Missense_Mutation_p.L507S			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	683	Protein kinase.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						CATACTTACTTACTTTATTCC	0.428000													4	89					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17450217	17450217	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:17450217G>A	ENST00000302539.4	-	13	1943	c.1817_splice	c.e13-1	p.S606_splice	ABCC8_ENST00000389817.3_Splice_Site_p.S606_splice	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	606					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GCTTTTGCACGCTGCTCGGGA	0.637000													24	12					0	0	1	0	0
ADSSL1	122622	broad.mit.edu	37	14	105208270	105208270	+	Silent	SNP	C	C	T	rs148388939		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105208270C>T	ENST00000332972.5	+	9	1167	c.1008C>T	c.(1006-1008)gaC>gaT	p.D336D	ADSSL1_ENST00000330877.2_Silent_p.D293D	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	293	Substrate binding (By similarity).				AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	ACATAGGTGACGTGTATGGCG	0.632000													11	74					0	0	1	0	0
NACC1	112939	broad.mit.edu	37	19	13246945	13246945	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13246945C>T	ENST00000292431.4	+	2	1050	c.924C>T	c.(922-924)agC>agT	p.S308S		NM_052876.3	NP_443108.1	Q96RE7	NACC1_HUMAN	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	308					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body				endometrium(3)|large_intestine(2)|lung(3)|skin(1)	9						CCATGTACAGCATGATGAACG	0.617000													9	14					0	0	1	0	0
CCR7	1236	broad.mit.edu	37	17	38711730	38711730	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38711730G>A	ENST00000246657.2	-	3	463	c.401C>T	c.(400-402)gCc>gTc	p.A134V	CCR7_ENST00000579344.1_Missense_Mutation_p.A128V	NM_001838.3	NP_001829.1	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7	134					cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		Breast(137;0.000496)				CTTGTAGATGGCAAAGATGAG	0.567000													7	18					0	0	1	0	0
DCDC2	51473	broad.mit.edu	37	6	24178685	24178685	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:24178685C>T	ENST00000378454.3	-	9	1500	c.1199G>A	c.(1198-1200)cGc>cAc	p.R400H	DCDC2_ENST00000378450.3_Missense_Mutation_p.R153H	NM_001195610.1|NM_016356.3	NP_001182539.1|NP_057440.2	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	400					cellular defense response|intracellular signal transduction|neuron migration			p.R400H(1)		breast(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32		Ovarian(999;0.101)				ACGAGCAGGGCGTGCCTGCTG	0.517000													16	70					0	0	1	0	0
CAND2	23066	broad.mit.edu	37	3	12859357	12859357	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:12859357C>T	ENST00000456430.2	+	10	2967	c.2926C>T	c.(2926-2928)Cgg>Tgg	p.R976W	CAND2_ENST00000295989.5_Missense_Mutation_p.R883W	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	976					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GCCCCGCTTGCGGAAGCAGCT	0.657000													19	23					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100235780	100235780	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:100235780G>A	ENST00000355295.4	+	11	2246	c.1951G>A	c.(1951-1953)Gcc>Acc	p.A651T	TDRD7_ENST00000422139.2_Missense_Mutation_p.A577T|TDRD7_ENST00000540902.1_5'UTR	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	651					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				ATAGGTTGACGCCATGTACAC	0.438000													27	63					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1046292	1046292	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1046292C>T	ENST00000263094.6	+	13	1740	c.1509C>T	c.(1507-1509)ttC>ttT	p.F503F	ABCA7_ENST00000533574.1_3'UTR|ABCA7_ENST00000435683.2_Silent_p.F365F|ABCA7_ENST00000433129.1_Silent_p.F503F	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	503					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGCGGCTTCGTGTACCTGC	0.697000													84	128					0	0	1	0	0
SLC38A2	54407	broad.mit.edu	37	12	46756336	46756336	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:46756336G>A	ENST00000256689.5	-	14	1709	c.1265C>T	c.(1264-1266)gCa>gTa	p.A422V	SLC38A2_ENST00000551374.1_Missense_Mutation_p.A260V	NM_018976.4	NP_061849.2	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	422					cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	18	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		ATTGGTAAATGCCAAGATAGA	0.363000													23	41					0	0	1	0	0
GABRB1	2560	broad.mit.edu	37	4	47428008	47428008	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:47428008C>T	ENST00000295454.3	+	9	1690	c.1398C>T	c.(1396-1398)gtC>gtT	p.V466V	GABRB1_ENST00000538619.1_Silent_p.V396V	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	466					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTTTTAATGTCGTCTATTGGC	0.418000													46	76					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19969540	19969540	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19969540C>T	ENST00000263207.3	-	4	576	c.285G>A	c.(283-285)acG>acA	p.T95T	ARVCF_ENST00000487793.1_5'UTR|ARVCF_ENST00000344269.3_Silent_p.T32T|ARVCF_ENST00000406522.1_Silent_p.T32T|ARVCF_ENST00000406259.1_Silent_p.T95T|ARVCF_ENST00000401994.1_Silent_p.T32T	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	95					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					CCTCCTCCACCGTCACGGTCT	0.647000													20	23					0	0	1	0	0
AARS2	57505	broad.mit.edu	37	6	44279880	44279880	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:44279880C>A	ENST00000244571.4	-	2	366	c.364G>T	c.(364-366)Ggt>Tgt	p.G122C		NM_020745.3	NP_065796.1	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	122					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	AGGTCTCGACCCACATCTTCC	0.522000													40	55					2.24893e-16	2.47033e-16	1	1	0
RP4-604K5.1	0	broad.mit.edu	37	1	87369093	87369093	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:87369093G>A	ENST00000331835.5	-	2	376	c.114C>T	c.(112-114)tgC>tgT	p.C38C	RP4-604K5.1_ENST00000401030.3_Silent_p.C38C|RP4-604K5.1_ENST00000370554.1_Silent_p.C38C|RP4-604K5.1_ENST00000469566.1_5'UTR	NM_004261.3	NP_004252.2																					CTAACTCTCTGCATGCCTCCG	0.418000													6	18					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169122822	169122822	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:169122822G>T	ENST00000256935.8	+	10	939	c.859G>T	c.(859-861)Gac>Tac	p.D287Y		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	287					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding	p.D287Y(1)		NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGAAACAAAGACCTCAACAG	0.418000													37	63					2.87052e-16	3.15041e-16	1	1	0
ZIM2	23619	broad.mit.edu	37	19	57286765	57286765	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:57286765G>T	ENST00000391708.3	-	12	1417	c.875C>A	c.(874-876)tCt>tAt	p.S292Y	ZIM2_ENST00000601070.1_Missense_Mutation_p.S292Y|AC006115.3_ENST00000594400.1_RNA|ZIM2_ENST00000221722.5_Missense_Mutation_p.S292Y|ZIM2_ENST00000599935.1_Missense_Mutation_p.S292Y|ZIM2_ENST00000593711.1_Missense_Mutation_p.S292Y|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000595954.1_RNA	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		ACTAAGATTAGAGCTTCTCTC	0.463000													29	62					1.06801e-11	1.15033e-11	1	1	0
NXPE1	120400	broad.mit.edu	37	11	114401164	114401164	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:114401164G>A	ENST00000536312.1	-	6	1458	c.566C>T	c.(565-567)gCg>gTg	p.A189V	NXPE1_ENST00000424269.1_Missense_Mutation_p.A189V|NXPE1_ENST00000251921.2_Missense_Mutation_p.A47V					neurexophilin and PC-esterase domain family, member 1																		GAGAGCCGACGCCCCTTCACT	0.512000													19	24					0	0	1	0	0
KIFC3	3801	broad.mit.edu	37	16	57794985	57794985	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:57794985G>A	ENST00000379655.4	-	15	2228	c.1971C>T	c.(1969-1971)ggC>ggT	p.G657G	KIFC3_ENST00000541240.1_Silent_p.G679G|KIFC3_ENST00000465878.2_Silent_p.G518G|KIFC3_ENST00000543930.1_Silent_p.G515G|KIFC3_ENST00000540079.2_Silent_p.G555G|KIFC3_ENST00000539578.1_Silent_p.G599G|KIFC3_ENST00000445690.2_Silent_p.G657G|KIFC3_ENST00000421376.2_Silent_p.G518G|KIFC3_ENST00000562903.1_Silent_p.G518G	NM_005550.3	NP_005541.3	Q9BVG8	KIFC3_HUMAN	kinesin family member C3	657	Kinesin-motor.				epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(3)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(199;0.224)				TGCAGTCCACGCCTCGCACCG	0.642000													9	11					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72657535	72657535	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:72657535C>T	ENST00000425256.1	-	0	2376					NR_002164.1																						cgttgcattgcaggtcgataa	0.502000													106	163					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3210609	3210609	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:3210609G>A	ENST00000355072.5	+	46	6407	c.6262G>A	c.(6262-6264)Gtg>Atg	p.V2088M		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2088					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding	p.V2088M(1)		breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGATGGGCACGTGTCACTGGA	0.577000													5	25					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55033097	55033097	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55033097C>T	ENST00000417545.2	+	3	567	c.481C>T	c.(481-483)Cag>Tag	p.Q161*		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	145						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						AAAGAAAATGCAGTCTTTATG	0.423000													5	35					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11554426	11554426	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:11554426G>A	ENST00000262442.3	+	13	2206	c.2138G>A	c.(2137-2139)aGa>aAa	p.R713K	DNAH9_ENST00000454412.2_Missense_Mutation_p.R713K	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	713	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTTGAACCCAGAGAGATGAAA	0.438000													45	57					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165986537	165986537	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:165986537T>C	ENST00000360093.3	-	17	3326	c.2835A>G	c.(2833-2835)atA>atG	p.I945M	SCN3A_ENST00000409101.3_Missense_Mutation_p.I896M|SCN3A_ENST00000283254.7_Missense_Mutation_p.I945M	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	945						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ACATGGTCTCTATCCACTCTC	0.488000													5	100					0	0	1	0	0
WNT10A	80326	broad.mit.edu	37	2	219746967	219746967	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219746967C>T	ENST00000258411.3	+	2	831	c.198C>T	c.(196-198)ggC>ggT	p.G66G		NM_025216.2	NP_079492.2	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family, member 10A	66					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|cervix(1)|endometrium(2)|lung(6)|skin(2)	12		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CATTGCCAGGCCTGAGCCGGC	0.602000													13	20					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16377010	16377010	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16377010G>A	ENST00000375679.4	+	11	1079		c.e11-1		CLCNKB_ENST00000375667.3_Splice_Site	NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		ATCCCCCACAGCAAGCCTGTG	0.642000													16	47					0	0	1	0	0
SON	6651	broad.mit.edu	37	21	34924073	34924073	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:34924073T>C	ENST00000356577.4	+	3	3011	c.2536T>C	c.(2536-2538)Tta>Cta	p.L846L	SON_ENST00000381692.2_Intron|SON_ENST00000381679.4_Silent_p.L846L|SON_ENST00000290239.6_Silent_p.L846L|SON_ENST00000300278.4_Silent_p.L846L	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	846	17 X 10 AA tandem repeats of L-A-[ST]- [NSG]-[TS]-MDSQM.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						TTCTCAGATGTTAGCAACCAG	0.493000													85	34					0	0	1	0	0
NDST1	3340	broad.mit.edu	37	5	149907854	149907854	+	Silent	SNP	C	C	T	rs147214079	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149907854C>T	ENST00000261797.6	+	3	1504	c.1002C>T	c.(1000-1002)gaC>gaT	p.D334D	NDST1_ENST00000523767.1_Silent_p.D334D	NM_001543.4	NP_001534.1	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	334	Heparan sulfate N-deacetylase 1.				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	34		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGTGGAGGACGTGAAGGTAT	0.622000													17	22					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12274268	12274268	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:12274268C>T	ENST00000261349.4	-	23	4710	c.4634G>A	c.(4633-4635)cGg>cAg	p.R1545Q	BCL2L14_ENST00000396369.1_Intron|LRP6_ENST00000543091.1_Missense_Mutation_p.R1500Q	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1545					cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				GGTCATTCTCCGACTAGGAGC	0.537000													24	50					0	0	1	0	0
ACOX1	51	broad.mit.edu	37	17	73969706	73969706	+	Splice_Site	SNP	C	C	T	rs140541455		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73969706C>T	ENST00000301608.4	-	3	490	c.430_splice	c.e3+1	p.G144_splice	ACOX1_ENST00000591857.1_Intron|ACOX1_ENST00000537812.1_Intron|ACOX1_ENST00000293217.5_Intron	NM_007292.5	NP_009223.2	Q15067	ACOX1_HUMAN	acyl-CoA oxidase 1, palmitoyl	144					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(1)	14						GTGGACTAACCGTGGCCCATT	0.493000													8	30					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5037204	5037204	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:5037204G>T	ENST00000574788.1	+	15	2637	c.407G>T	c.(406-408)aGg>aTg	p.R136M	USP6_ENST00000304328.5_5'UTR|USP6_ENST00000332776.4_Missense_Mutation_p.R136M|USP6_ENST00000250066.6_Missense_Mutation_p.R136M			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	136	Rab-GAP TBC.				protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						AGGGGCAAGAGGTCATCTGAA	0.557000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								17	46					1.00905e-13	1.09755e-13	1	1	0
TACC1	6867	broad.mit.edu	37	8	38677710	38677710	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:38677710A>G	ENST00000379931.3	+	3	1327	c.948A>G	c.(946-948)tcA>tcG	p.S316S	TACC1_ENST00000518415.1_Silent_p.S271S|TACC1_ENST00000348567.4_Intron|TACC1_ENST00000520973.1_Silent_p.S121S|TACC1_ENST00000317827.4_Silent_p.S316S|TACC1_ENST00000443286.2_Silent_p.S332S|TACC1_ENST00000522752.1_Intron|TACC1_ENST00000330691.6_Intron|TACC1_ENST00000520615.1_Silent_p.S121S|TACC1_ENST00000520340.1_Silent_p.S280S|TACC1_ENST00000276520.8_Intron|TACC1_ENST00000519416.1_Silent_p.S121S			O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing protein 1	316	Interaction with YEATS4.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(3)	17		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			CGAGGAGCTCACCTCTCAAGC	0.527000													14	17					0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48602517	48602517	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:48602517C>T	ENST00000340553.3	+	7	1492	c.1231C>T	c.(1231-1233)Cgt>Tgt	p.R411C		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	411					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			TGCTGGAATTCGTACATGTTT	0.393000													3	23					0	0	1	0	0
ATIC	471	broad.mit.edu	37	2	216214268	216214268	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:216214268G>A	ENST00000435675.1	+	15	2057	c.1666G>A	c.(1666-1668)Gcg>Acg	p.A556T	ATIC_ENST00000236959.9_Missense_Mutation_p.A557T|ATIC_ENST00000540518.1_Missense_Mutation_p.A498T			P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	557					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	large_intestine(2)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	8		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	GAGTGGTGTGGCGTACATTGC	0.463000			T	ALK	ALCL								6	42					0	0	1	0	0
JAK2	3717	broad.mit.edu	37	9	5069188	5069188	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:5069188G>A	ENST00000381652.3	+	11	1987	c.1493G>A	c.(1492-1494)tGc>tAc	p.C498Y	JAK2_ENST00000539801.1_Missense_Mutation_p.C498Y|JAK2_ENST00000544510.1_Missense_Mutation_p.C349Y	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	498					actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TTTACTAAATGCTGTCCCCCA	0.343000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				13	34					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28993158	28993158	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:28993158C>T	ENST00000359747.4	+	15	2809	c.2780C>T	c.(2779-2781)aCt>aTt	p.T927I	RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.T908I	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	908					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ATTATTGTGACTGAGACTTAC	0.423000													56	87					0	0	1	0	0
IL20RA	53832	broad.mit.edu	37	6	137323047	137323047	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:137323047G>A	ENST00000367748.1	-	6	1563	c.977C>T	c.(976-978)gCg>gTg	p.A326V	IL20RA_ENST00000316649.5_Missense_Mutation_p.A437V|IL20RA_ENST00000541547.1_Missense_Mutation_p.A388V			Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha	437						integral to membrane	receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		GACTGCCAACGCTGCCTGCGA	0.572000													10	49					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976522	38976522	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38976522G>A	ENST00000355481.4	+	34	5358	c.5227G>A	c.(5227-5229)Gcc>Acc	p.A1743T	RYR1_ENST00000360985.3_Missense_Mutation_p.A1743T|RYR1_ENST00000359596.3_Missense_Mutation_p.A1743T	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1743	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGAGACCCGCGCCATCACGCT	0.622000													20	33					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113519034	113519034	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:113519034C>A	ENST00000297405.5	-	29	5025	c.4781G>T	c.(4780-4782)gGa>gTa	p.G1594V	CSMD3_ENST00000343508.3_Missense_Mutation_p.G1554V|CSMD3_ENST00000352409.3_Missense_Mutation_p.G1594V|CSMD3_ENST00000455883.2_Missense_Mutation_p.G1490V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1594	CUB 9.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GCCTGAAGATCCTGTTAAATT	0.348000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	18					0.0293803	0.0295506	1	1	0
TNIP1	10318	broad.mit.edu	37	5	150436423	150436423	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150436423G>A	ENST00000389378.2	-	6	1119	c.531C>T	c.(529-531)caC>caT	p.H177H	TNIP1_ENST00000523338.1_Silent_p.H177H|TNIP1_ENST00000520931.1_Silent_p.H124H|TNIP1_ENST00000521591.1_Silent_p.H177H|TNIP1_ENST00000524280.1_Silent_p.H177H|TNIP1_ENST00000522226.1_Silent_p.H177H|TNIP1_ENST00000518977.1_Silent_p.H177H|TNIP1_ENST00000315050.7_Silent_p.H177H|TNIP1_ENST00000523200.1_Silent_p.H177H	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	177	Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGAGCTGGCCGTGGTCCGGCT	0.657000													22	19					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86203178	86203178	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:86203178C>T	ENST00000370571.2	-	58	5049	c.4683G>A	c.(4681-4683)tgG>tgA	p.W1561*	COL24A1_ENST00000436319.1_Nonsense_Mutation_p.W1540*	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1561	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTGGGTCAATCCAGTATTTTC	0.343000													9	16					0	0	1	0	0
PCDHGA1	0	broad.mit.edu	37	5	140712162	140712162	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140712162G>A	ENST00000517417.1	+	1	1911	c.1911G>A	c.(1909-1911)gcG>gcA	p.A637A	PCDHGA1_ENST00000378105.3_Silent_p.A637A	NM_018912.2	NP_061735.1												p.A637A(1)		breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGAGACGCGCTCAAGCAGA	0.697000													25	17					0	0	1	0	0
PREP	5550	broad.mit.edu	37	6	105781268	105781268	+	Silent	SNP	G	G	A	rs147800201		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:105781268G>A	ENST00000369110.3	-	8	1128	c.936C>T	c.(934-936)cgC>cgT	p.R312R		NM_002726.4	NP_002717.3	P48147	PPCE_HUMAN	prolyl endopeptidase	312					proteolysis		serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	TGTTGATCACGCGATAGTTGG	0.448000													5	101					0	0	1	0	0
PPP1R12C	54776	broad.mit.edu	37	19	55624037	55624037	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55624037C>T	ENST00000263433.3	-	2	463	c.448G>A	c.(448-450)Gcc>Acc	p.A150T	PPP1R12C_ENST00000435544.2_Missense_Mutation_p.A76T|PPP1R12C_ENST00000376393.2_Missense_Mutation_p.A150T	NM_001271618.1|NM_017607.2	NP_001258547.1|NP_060077.1	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	150						cytoplasm		p.A150T(1)		central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	22			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CCTCACCTGGCGATATCTAGG	0.692000													14	19					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42169534	42169534	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:42169534C>T	ENST00000444063.1	+	18	2335	c.2203C>T	c.(2203-2205)Cgt>Tgt	p.R735C	L3MBTL1_ENST00000427442.2_Intron|L3MBTL1_ENST00000418998.1_Intron|L3MBTL1_ENST00000373134.1_Missense_Mutation_p.R740C|L3MBTL1_ENST00000373135.3_Intron			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	0	SAM.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						CCCTCCCCAGCGTCACTTCTG	0.582000													4	9					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10439365	10439365	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10439365C>T	ENST00000293677.6	-	3	841	c.760G>A	c.(760-762)Gct>Act	p.A254T		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	237	RRM 3.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CGGCACAGAGCGTCCACATCG	0.667000													4	0					0	0	1	0	0
XRCC6	2547	broad.mit.edu	37	22	42032741	42032741	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:42032741G>A	ENST00000359308.4	+	4	1211	c.556G>A	c.(556-558)Gcc>Acc	p.A186T	XRCC6_ENST00000402580.3_Missense_Mutation_p.A145T|XRCC6_ENST00000428575.2_Missense_Mutation_p.A53T|XRCC6_ENST00000405506.1_Missense_Mutation_p.A136T|XRCC6_ENST00000360079.3_Missense_Mutation_p.A186T|XRCC6_ENST00000405878.1_Missense_Mutation_p.A186T			P12956	XRCC6_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 6	186					DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	31						AGCCAGCCGGGCCAGGACCAA	0.423000								Non-homologous end-joining					5	52					0	0	1	0	0
P2RX1	5023	broad.mit.edu	37	17	3819513	3819513	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3819513G>A	ENST00000225538.3	-	1	281	c.7C>T	c.(7-9)Cgg>Tgg	p.R3W		NM_002558.2	NP_002549.1	P51575	P2RX1_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 1	3					platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	13				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		TGGAACCGCCGTGCCATGGTG	0.637000													4	82					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108861786	108861786	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:108861786C>T	ENST00000356922.4	-	2	2103	c.1831G>A	c.(1831-1833)Gca>Aca	p.A611T	LIG4_ENST00000405925.1_Missense_Mutation_p.A611T|LIG4_ENST00000442234.1_Missense_Mutation_p.A611T	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	611					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TGTTTAGATGCGAGCTTACCA	0.423000								Non-homologous end-joining					28	40					0	0	1	0	0
ANAPC4	29945	broad.mit.edu	37	4	25382011	25382011	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:25382011C>T	ENST00000315368.3	+	3	287	c.145C>T	c.(145-147)Ctg>Ttg	p.L49L	ANAPC4_ENST00000510092.1_Silent_p.L49L	NM_013367.2	NP_037499.2	Q9UJX5	APC4_HUMAN	anaphase promoting complex subunit 4	49					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	27		Breast(46;0.0503)				ACTTCATCGACTGGCAAGTTT	0.348000													7	15					0	0	1	0	0
LMNB2	84823	broad.mit.edu	37	19	2434012	2434012	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2434012C>T	ENST00000325327.3	-	8	1356	c.1294G>A	c.(1294-1296)Ggc>Agc	p.G432S	LMNB2_ENST00000582871.1_Missense_Mutation_p.G412S			Q03252	LMNB2_HUMAN	lamin B2	412	Tail.			LEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVS -> WRWRSPWQRPKRPGHGHGWQRWLPPGPAGLGLGQRH (in Ref. 5; AAA80979).		nuclear inner membrane	structural molecule activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTACTGCGGCCCAGGCGCCCG	0.721000													6	7					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75115100	75115100	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:75115100C>T	ENST00000290573.2	+	16	2890	c.2290C>T	c.(2290-2292)Cgt>Tgt	p.R764C	HK2_ENST00000409174.1_Missense_Mutation_p.R736C	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	764	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						TTTCACCAAGCGTGGACTACT	0.478000													21	42					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103131217	103131217	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:103131217C>T	ENST00000428762.1	-	59	9662	c.9503G>A	c.(9502-9504)gGc>gAc	p.G3168D	RELN_ENST00000343529.5_Missense_Mutation_p.G3168D|RELN_ENST00000424685.2_Missense_Mutation_p.G3168D|CTB-107G13.1_ENST00000422488.1_RNA	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3168					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGGGGAGCAGCCAATGCTGTT	0.488000													30	33					0	0	1	0	0
ADRA2C	152	broad.mit.edu	37	4	3769056	3769056	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:3769056G>A	ENST00000330055.5	+	1	932	c.723G>A	c.(721-723)acG>acA	p.T241T	ADRA2C_ENST00000509482.1_Silent_p.T241T	NM_000683.3	NP_000674.2	P18825	ADA2C_HUMAN	adrenoceptor alpha 2C	241					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	AGCTGCGCACGCGCACGCTCA	0.706000													3	6					0	0	1	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	77094429	77094429	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:77094429T>C	ENST00000328299.3	+	5	1004	c.856T>C	c.(856-858)Ttt>Ctt	p.F286L		NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	286					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						AAAGAAAGTGTTTGCTAAATG	0.378000													4	76					0	0	1	0	0
PANK4	55229	broad.mit.edu	37	1	2452330	2452330	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:2452330G>A	ENST00000378466.3	-	4	450	c.438C>T	c.(436-438)gaC>gaT	p.D146D	PANK4_ENST00000435556.3_Intron	NM_018216.1	NP_060686.1	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	146					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			breast(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	23	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		ACGTCATCACGTCCTCCTTGT	0.572000													28	16					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7919139	7919139	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7919139G>A	ENST00000254854.4	+	16	3173	c.3023G>A	c.(3022-3024)cGc>cAc	p.R1008H		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	1008	Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				ACCGCCTCGCGCATGGAGTCC	0.697000													11	9					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1797000	1797000	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1797000C>T	ENST00000539485.1	-	15	1790	c.1557G>A	c.(1555-1557)ccG>ccA	p.P519P	ATP8B3_ENST00000310127.6_Silent_p.P519P|ATP8B3_ENST00000525591.1_Silent_p.P472P			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	519					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCTGAATCCGGCCCTGGGG	0.692000													13	16					0	0	1	0	0
TTC6	319089	broad.mit.edu	37	14	38273919	38273919	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:38273919C>T	ENST00000553443.1	+	21	4064	c.4064C>T	c.(4063-4065)gCc>gTc	p.A1355V	TTC6_ENST00000267368.7_Missense_Mutation_p.A86V|TTC6_ENST00000382320.3_Missense_Mutation_p.A69V|TTC6_ENST00000476979.1_Missense_Mutation_p.A86V					tetratricopeptide repeat domain 6											central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	14	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;1.59e-06)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0543)|all cancers(34;0.108)|BRCA - Breast invasive adenocarcinoma(188;0.156)|LUSC - Lung squamous cell carcinoma(13;0.176)	GBM - Glioblastoma multiforme(112;0.00551)		GCTTTGGATGCCATTTCTCAT	0.398000													77	92					0	0	1	0	0
OSBPL11	114885	broad.mit.edu	37	3	125271044	125271044	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:125271044G>A	ENST00000296220.5	-	9	1924	c.1635C>T	c.(1633-1635)ggC>ggT	p.G545G		NM_022776.4	NP_073613.2	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	545					lipid transport		lipid binding			NS(1)|breast(1)|cervix(1)|kidney(2)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	27						CCATTGTCACGCCTATTGACA	0.338000													25	44					0	0	1	0	0
SPRY4	81848	broad.mit.edu	37	5	141694197	141694197	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:141694197G>A	ENST00000344120.4	-	3	732	c.546C>T	c.(544-546)tgC>tgT	p.C182C	SPRY4_ENST00000434127.2_Silent_p.C159C	NM_030964.3	NP_112226.2	Q9C004	SPY4_HUMAN	sprouty homolog 4 (Drosophila)	159	Cys-rich.|SPR.				multicellular organismal development	cytoplasm|ruffle membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(1)	18		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAGGCCTCGCACAGCAAGA	0.642000									Testicular Cancer, Familial Clustering of				11	41					0	0	1	0	0
RAD17	5884	broad.mit.edu	37	5	68670493	68670493	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:68670493C>T	ENST00000509734.1	+	5	1017	c.339C>T	c.(337-339)gtC>gtT	p.V113V	RAD17_ENST00000521422.1_5'UTR|RAD17_ENST00000504177.1_Intron|RAD17_ENST00000380774.3_Silent_p.V113V|RAD17_ENST00000361732.2_Silent_p.V102V|RAD17_ENST00000358030.2_5'UTR|RAD17_ENST00000345306.6_Silent_p.V102V|RAD17_ENST00000354868.5_Silent_p.V102V|RAD17_ENST00000354312.3_Silent_p.V102V|RAD17_ENST00000282891.6_Silent_p.V16V|RAD17_ENST00000305138.4_Silent_p.V102V			O75943	RAD17_HUMAN	RAD17 homolog (S. pombe)	113					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding						Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		TTGAAGAAGTCGAAACCTGGT	0.279000								Other conserved DNA damage response genes					25	33					0	0	1	0	0
SPATA7	55812	broad.mit.edu	37	14	88895732	88895732	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:88895732C>A	ENST00000556553.1	+	8	1416	c.857C>A	c.(856-858)gCt>gAt	p.A286D	SPATA7_ENST00000045347.7_Missense_Mutation_p.A318D|SPATA7_ENST00000356583.5_Missense_Mutation_p.A286D|SPATA7_ENST00000393545.4_Missense_Mutation_p.A318D			Q9P0W8	SPAT7_HUMAN	spermatogenesis associated 7	318					response to stimulus|visual perception					cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	18						GAAAAAATAGCTCCTTTACCT	0.348000													20	33					7.41877e-09	7.84611e-09	1	1	0
KDM5B	10765	broad.mit.edu	37	1	202710525	202710525	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:202710525T>C	ENST00000367265.3	-	19	4079	c.2915A>G	c.(2914-2916)gAc>gGc	p.D972G	KDM5B_ENST00000367264.2_Missense_Mutation_p.D1008G	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	972					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						GGCTTTGTCGTCCCAGTGCTC	0.522000													15	30					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99565869	99565869	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99565869G>A	ENST00000411734.1	-	3	518	c.513C>T	c.(511-513)taC>taT	p.Y171Y	AZGP1_ENST00000292401.4_Silent_p.Y174Y			P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	174					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CCCGCTGCACGTAGACTGGTT	0.532000													43	38					0	0	1	0	0
PCDHGB6	0	broad.mit.edu	37	5	140788076	140788076	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140788076G>A	ENST00000520790.1	+	1	307	c.307G>A	c.(307-309)Gag>Aag	p.E103K	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAAGATGTGAGTTGCAATT	0.438000													23	57					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128910367	128910367	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128910367C>T	ENST00000375990.3	+	19	2357	c.1954C>T	c.(1954-1956)Ccc>Tcc	p.P652S	UGGT1_ENST00000259253.6_Missense_Mutation_p.P676S			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	676					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						GGGTGAACTGCCCCATGATCA	0.368000													6	133					0	0	1	0	0
MMACHC	25974	broad.mit.edu	37	1	45974469	45974469	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:45974469G>A	ENST00000401061.4	+	4	711	c.429_splice	c.e4-1	p.R144_splice		NM_015506.2	NP_056321.2	Q9Y4U1	MMAC_HUMAN	methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria	144							cobalamin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	8	Acute lymphoblastic leukemia(166;0.155)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCTCCCCAGCGCATATCAGGT	0.572000													3	13					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109793291	109793291	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109793291G>A	ENST00000271332.3	+	1	651	c.590G>A	c.(589-591)gGc>gAc	p.G197D		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	197	Cadherin 1.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CAGCCAGCAGGCACCCCTGTT	0.622000													12	24					0	0	1	0	0
BRF2	55290	broad.mit.edu	37	8	37704638	37704638	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:37704638C>A	ENST00000220659.6	-	3	390	c.270G>T	c.(268-270)gaG>gaT	p.E90D	BRF2_ENST00000520601.1_Missense_Mutation_p.E90D|BRF2_ENST00000521170.1_3'UTR	NM_018310.3	NP_060780.2	Q9HAW0	BRF2_HUMAN	BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit	90					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)	12		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			CCGCGGTATCCTCAAATGTTG	0.542000													27	57					2.24059e-21	2.48785e-21	1	1	0
PAPLN	89932	broad.mit.edu	37	14	73726174	73726174	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:73726174G>A	ENST00000427855.1	+	16	2008	c.1906G>A	c.(1906-1908)Ggg>Agg	p.G636R	PAPLN_ENST00000381166.3_Missense_Mutation_p.G636R|PAPLN_ENST00000555445.1_Missense_Mutation_p.G636R|PAPLN_ENST00000554301.1_Missense_Mutation_p.G636R|PAPLN_ENST00000340738.5_Missense_Mutation_p.G609R			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	636						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CAGTCCTCACGGGTGCTGCCC	0.697000													5	5					0	0	1	0	0
EPHB6	0	broad.mit.edu	37	7	142562420	142562420	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142562420G>A	ENST00000392957.2	+	7	1649	c.862G>A	c.(862-864)Ggg>Agg	p.G288R	EPHB6_ENST00000442129.1_Missense_Mutation_p.G288R|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	288	Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GCACTGCAACGGGGAGGGCAA	0.667000													34	39					0	0	1	0	0
NKAP	79576	broad.mit.edu	37	X	119064005	119064005	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:119064005G>A	ENST00000371410.3	-	8	1213	c.1047C>T	c.(1045-1047)tgC>tgT	p.C349C	NKAP_ENST00000477789.1_5'UTR	NM_024528.3	NP_078804.2	Q8N5F7	NKAP_HUMAN	NFKB activating protein	349	Necessary for interaction with HDAC3 and transcriptional repression.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						CATAACCTGAGCATTCAAATG	0.368000													33	5					0	0	1	0	0
C3orf36	80111	broad.mit.edu	37	3	133647492	133647492	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:133647492C>T	ENST00000408895.2	-	1	1164	c.156G>A	c.(154-156)acG>acA	p.T52T		NM_025041.2	NP_079317.2	Q3SXR2	CC036_HUMAN	chromosome 3 open reading frame 36	52										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	6						CCTTCCTGAGCGTGGTTGGTG	0.642000													9	7					0	0	1	0	0
PLEKHM2	23207	broad.mit.edu	37	1	16053821	16053821	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16053821C>T	ENST00000375799.3	+	9	1481	c.1254C>T	c.(1252-1254)aaC>aaT	p.N418N	PLEKHM2_ENST00000375793.2_Silent_p.N398N|RP11-288I21.1_ENST00000453804.1_RNA	NM_015164.2	NP_055979.2	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 2	418					Golgi organization	cytoplasm	kinesin binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ACCAGCTCAACGGGCAGCTGG	0.682000													5	3					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53683373	53683373	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53683373C>T	ENST00000257934.4	+	22	5199	c.5108C>T	c.(5107-5109)cCc>cTc	p.P1703L	ESPL1_ENST00000552462.1_Missense_Mutation_p.P1703L	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1703					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						GCTCTGATCCCCAGTGGTATG	0.567000													19	33					0	0	1	0	0
UNC5CL	222643	broad.mit.edu	37	6	41001660	41001660	+	Missense_Mutation	SNP	C	C	T	rs141624251	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:41001660C>T	ENST00000244565.3	-	3	734	c.646G>A	c.(646-648)Gcc>Acc	p.A216T	UNC5CL_ENST00000373164.1_Missense_Mutation_p.A216T	NM_173561.2	NP_775832.2	Q8IV45	UN5CL_HUMAN	unc-5 homolog C (C. elegans)-like	216	Interaction with RELA and NFKB1.				signal transduction	cytoplasm|integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					TCCCGGGAGGCGTGGGCCCCC	0.632000													11	14					0	0	1	0	0
EMX2	2018	broad.mit.edu	37	10	119305250	119305250	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:119305250G>A	ENST00000553456.3	+	2	1338	c.514G>A	c.(514-516)Gcc>Acc	p.A172T	EMX2_ENST00000442245.4_Intron|EMX2_ENST00000546446.1_3'UTR	NM_004098.3	NP_004089.1	Q04743	EMX2_HUMAN	empty spiracles homeobox 2	172						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(2)	12		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		GCTGGAACACGCCTTTGAGAA	0.622000													14	20					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10714603	10714603	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:10714603G>A	ENST00000377022.3	-	10	2028	c.1711C>T	c.(1711-1713)Cac>Tac	p.H571Y	CASZ1_ENST00000344008.5_Missense_Mutation_p.H571Y	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		AAGTTCTCGTGGGTCATCACG	0.597000													28	83					0	0	1	0	0
USP5	0	broad.mit.edu	37	12	6967709	6967709	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6967709G>A	ENST00000229268.8	+	8	1038	c.986G>A	c.(985-987)cGg>cAg	p.R329Q	USP5_ENST00000389231.5_Missense_Mutation_p.R329Q	NM_001098536.1	NP_001092006.1	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 (isopeptidase T)	329					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(6)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|skin(2)|urinary_tract(2)	36						ACAGGCATCCGGAACCTGGGT	0.567000													8	15					0	0	1	0	0
MEN1	0	broad.mit.edu	37	11	64572519	64572519	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64572519C>T	ENST00000337652.1	-	9	1855	c.1352G>A	c.(1351-1353)cGt>cAt	p.R451H	MEN1_ENST00000394374.2_Missense_Mutation_p.R451H|MEN1_ENST00000443283.1_Missense_Mutation_p.R451H|MEN1_ENST00000394376.1_Missense_Mutation_p.R451H|MEN1_ENST00000377326.3_Missense_Mutation_p.R446H|MEN1_ENST00000377313.1_Missense_Mutation_p.R451H|MEN1_ENST00000377321.1_Missense_Mutation_p.R411H|MEN1_ENST00000315422.4_Missense_Mutation_p.R446H|MEN1_ENST00000312049.6_Missense_Mutation_p.R446H|MEN1_ENST00000478548.1_5'UTR|MEN1_ENST00000377316.2_Intron	NM_130803.2	NP_570715.1	O00255	MEN1_HUMAN	multiple endocrine neoplasia I	451					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						TCCCTCAAAACGGCCTAGGGA	0.612000			"""D, Mis, N, F, S"""		"""parathyroid tumors, Pancreatic neuroendocrine tumors"""	"""parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"""			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated				10	31					0	0	1	0	0
FEM1C	56929	broad.mit.edu	37	5	114879005	114879005	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:114879005C>T	ENST00000274457.3	-	2	747	c.186G>A	c.(184-186)gaG>gaA	p.E62E		NM_020177.2	NP_064562.1	Q96JP0	FEM1C_HUMAN	fem-1 homolog c (C. elegans)	62						cytoplasm				breast(5)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	18		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		CACTGCATTGCTCTAGGAGGA	0.542000													4	18					0	0	1	0	0
MALAT1	0	broad.mit.edu	37	11	65269670	65269670	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65269670G>A	ENST00000534336.1	+	0	4438					NR_002819.2																						GGTTGGTCTGGCCTACTGGGC	0.373000													10	19					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47881294	47881294	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:47881294G>A	ENST00000396105.1	-	5	2356	c.2110C>T	c.(2110-2112)Cgc>Tgc	p.R704C	ZNFX1_ENST00000371752.1_Missense_Mutation_p.R704C|ZNFX1_ENST00000371754.4_Missense_Mutation_p.R704C	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	704							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AGGTTGCGGCGGAATTCCCGC	0.527000													36	57					0	0	1	0	0
HPDL	84842	broad.mit.edu	37	1	45792871	45792871	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:45792871C>T	ENST00000334815.3	+	1	327	c.51C>T	c.(49-51)gcC>gcT	p.A17A		NM_032756.2	NP_116145.1	Q96IR7	HPDL_HUMAN	4-hydroxyphenylpyruvate dioxygenase-like	17					aromatic amino acid family metabolic process		4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	Acute lymphoblastic leukemia(166;0.155)					ACGTGCCCGCCGGGCAGCCCC	0.706000													3	22					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115391684	115391684	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:115391684C>T	ENST00000369358.4	-	17	1916	c.1672G>A	c.(1672-1674)Gga>Aga	p.G558R	NRAP_ENST00000360478.3_Missense_Mutation_p.G523R|NRAP_ENST00000359988.3_Missense_Mutation_p.G558R|NRAP_ENST00000369360.3_Missense_Mutation_p.G523R			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	558						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		ATCTCAAATCCTTTCCCCTTT	0.463000													23	31					0	0	1	0	0
CDK18	5129	broad.mit.edu	37	1	205495959	205495959	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:205495959C>T	ENST00000360066.2	+	8	1024	c.723C>T	c.(721-723)aaC>aaT	p.N241N	CDK18_ENST00000506784.1_Silent_p.N271N|CDK18_ENST00000509056.1_3'UTR|CDK18_ENST00000429964.2_Silent_p.N241N	NM_002596.3|NM_212502.2|NM_212503.2	NP_002587.2|NP_997667.1|NP_997668.1	Q07002	CDK18_HUMAN	cyclin-dependent kinase 18	239	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			breast(2)|endometrium(2)|large_intestine(2)|lung(10)|stomach(2)|urinary_tract(1)	19						GCATGCACAACGTCAAGGTGA	0.627000													27	55					0	0	1	0	0
PKN2	5586	broad.mit.edu	37	1	89250336	89250336	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:89250336C>T	ENST00000370521.3	+	7	1359	c.1000C>T	c.(1000-1002)Cgt>Tgt	p.R334C	PKN2_ENST00000544045.1_Missense_Mutation_p.R8C|PKN2_ENST00000316005.7_Missense_Mutation_p.R334C|PKN2_ENST00000370505.3_Missense_Mutation_p.R177C|PKN2_ENST00000370513.5_Missense_Mutation_p.R334C	NM_006256.2	NP_006247.1	Q16513	PKN2_HUMAN	protein kinase N2	334	C2.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(1)	33		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		TTTGGAAGTTCGTCTTATGGG	0.398000													25	30					0	0	1	0	0
OR2B2	81697	broad.mit.edu	37	6	27879581	27879581	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:27879581C>A	ENST00000303324.2	-	1	593	c.517G>T	c.(517-519)Gaa>Taa	p.E173*		NM_033057.2	NP_149046.2	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B, member 2	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|large_intestine(5)|lung(10)|prostate(1)|urinary_tract(1)	22						TGATCCACTTCTTTGTGACCA	0.463000													35	30					3.76114e-14	4.09844e-14	1	1	0
MED13L	23389	broad.mit.edu	37	12	116404036	116404036	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:116404036G>A	ENST00000281928.3	-	29	6444	c.6238C>T	c.(6238-6240)Cgt>Tgt	p.R2080C		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	2080					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GAAAGAAGACGCTCACCCTGG	0.443000													31	41					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126373279	126373279	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126373279G>A	ENST00000394329.3	+	9	11121	c.11108G>A	c.(11107-11109)gGa>gAa	p.G3703E	FAT4_ENST00000335110.5_Missense_Mutation_p.G2001E	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3703					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TTCTTTGCTGGATTTTCCAAT	0.458000													4	93					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43906960	43906960	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43906960C>T	ENST00000562955.1	+	52	7249	c.7249C>T	c.(7249-7251)Cgg>Tgg	p.R2417W	SZT2_ENST00000372442.1_Missense_Mutation_p.R1575W	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2474						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						AGAAGACACTCGGGGCCGGAG	0.552000													10	79					0	0	1	0	0
RAB4B-EGLN2	0	broad.mit.edu	37	19	41292855	41292855	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41292855C>T	ENST00000594136.1	+	7	734	c.629C>T	c.(628-630)cCg>cTg	p.P210L	RAB4B_ENST00000594800.1_Missense_Mutation_p.P210L|RAB4B-EGLN2_ENST00000601949.1_3'UTR|RAB4B_ENST00000357052.2_Missense_Mutation_p.P210L																							GCCCCTCAGCCGTGTGGCTGC	0.667000													5	10					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109371409	109371409	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:109371409C>T	ENST00000283195.6	+	16	2377	c.2251C>T	c.(2251-2253)Cag>Tag	p.Q751*		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	751					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TTCAGTCATGCAGGAACTCGA	0.373000													87	147					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168316027	168316027	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:168316027C>T	ENST00000366806.2	+	18	2600	c.2458C>T	c.(2458-2460)Cgt>Tgt	p.R820C	MLLT4_ENST00000344191.4_Missense_Mutation_p.R820C|MLLT4_ENST00000351017.4_Missense_Mutation_p.R827C|MLLT4_ENST00000392112.1_Missense_Mutation_p.R804C|MLLT4_ENST00000447894.2_Missense_Mutation_p.R820C|MLLT4_ENST00000392108.3_Missense_Mutation_p.R820C|MLLT4_ENST00000400822.3_Missense_Mutation_p.R819C			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	820	Dilute.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TGCGATTATCCGTCAGCAGTT	0.547000			T	MLL	AL								12	16					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88946188	88946188	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:88946188C>T	ENST00000556564.1	-	13	1871	c.1587G>A	c.(1585-1587)gaG>gaA	p.E529E	PTPN21_ENST00000328736.3_Silent_p.E529E	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	529						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						CGGGCCGCCGCTCGGCAGGGT	0.697000													8	38					0	0	1	0	0
ZC3H12D	340152	broad.mit.edu	37	6	149773850	149773850	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:149773850G>A	ENST00000389942.5	-	5	936	c.689C>T	c.(688-690)cCg>cTg	p.P230L	ZC3H12D_ENST00000416573.2_Missense_Mutation_p.P230L|ZC3H12D_ENST00000409806.3_Missense_Mutation_p.P230L|ZC3H12D_ENST00000542614.1_Missense_Mutation_p.P230L			A2A288	ZC12D_HUMAN	zinc finger CCCH-type containing 12D	230						cytoplasm|nucleus	endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	6		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.23e-11)|GBM - Glioblastoma multiforme(68;0.0921)		GTCATCAGGCGGCATGAACCT	0.587000													4	3					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112034009	112034009	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:112034009C>T	ENST00000371959.3	-	7	1927	c.1926_splice	c.e7-1	p.R643_splice	AMOT_ENST00000371962.1_Splice_Site_p.R411_splice|AMOT_ENST00000524145.1_Splice_Site_p.R643_splice|AMOT_ENST00000371958.1_Splice_Site_p.R411_splice|AMOT_ENST00000304758.1_Splice_Site_p.R234_splice	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	643					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity	p.R643H(1)|p.R234H(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						GTTGCCCTGACGCTGTTGGGG	0.527000													25	1					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30218380	30218380	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:30218380A>G	ENST00000397771.2	-	6	662	c.485T>C	c.(484-486)cTg>cCg	p.L162P	ASCC2_ENST00000542393.1_Missense_Mutation_p.L86P|ASCC2_ENST00000307790.3_Missense_Mutation_p.L162P			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			GCAGAGGTCCAGGATCTTTGG	0.478000													38	50					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105411028	105411028	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105411028C>T	ENST00000333244.5	-	7	10879	c.10760G>A	c.(10759-10761)gGc>gAc	p.G3587D	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3587						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGCCTTGGGGCCTTTCAGGTC	0.617000													76	93					0	0	1	0	0
PCDHA11	0	broad.mit.edu	37	5	140250616	140250616	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140250616G>A	ENST00000398640.2	+	1	1928	c.1928G>A	c.(1927-1929)cGc>cAc	p.R643H	PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACTCGCCGCGCCACCGACTT	0.687000													23	37					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139402764	139402764	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139402764C>T	ENST00000277541.6	-	20	3320	c.3245G>A	c.(3244-3246)cGc>cAc	p.R1082H		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1082	EGF-like 28.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCACTCGCAGCGGTACTGGGT	0.647000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			38	63					0	0	1	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32917165	32917165	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:32917165C>T	ENST00000374843.4	-	4	749	c.664G>A	c.(664-666)Gca>Aca	p.A222T	HLA-DMA_ENST00000395303.3_Missense_Mutation_p.A188T|HLA-DMA_ENST00000395305.3_Missense_Mutation_p.A127T|XXbac-BPG181M17.5_ENST00000429234.1_Intron|HLA-DMA_ENST00000464392.1_5'UTR	NM_006120.3	NP_006111.2	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM alpha	222						integral to membrane|MHC class II protein complex		p.A222S(2)		kidney(1)|large_intestine(2)|lung(8)	11						GAGGGCAGTGCGTTCCGGGGT	0.587000													3	3					0	0	1	0	0
AGPAT5	55326	broad.mit.edu	37	8	6605240	6605240	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:6605240C>T	ENST00000285518.6	+	6	948	c.636C>T	c.(634-636)caC>caT	p.H212H	AGPAT5_ENST00000530716.1_3'UTR	NM_018361.3	NP_060831.2	Q9NUQ2	PLCE_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 5	212					phospholipid biosynthetic process	integral to membrane|mitochondrion	1-acylglycerol-3-phosphate O-acyltransferase activity		AGPAT5/MCPH1(2)	endometrium(2)|kidney(2)|large_intestine(4)|lung(3)	11			STAD - Stomach adenocarcinoma(24;0.0578)	READ - Rectum adenocarcinoma(644;0.156)|COAD - Colon adenocarcinoma(149;0.191)		AGGCAACTCACGTTGCTTTTG	0.403000													23	42					0	0	1	0	0
BTN2A3P	0	broad.mit.edu	37	6	26431655	26431655	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:26431655C>T	ENST00000466808.2	+	0	1603																											GGAAGACACGCCCTCCTCCCC	0.572000													5	46					0	0	1	0	0
SEC24C	9632	broad.mit.edu	37	10	75519998	75519998	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:75519998G>T	ENST00000339365.2	+	6	866	c.704G>T	c.(703-705)aGt>aTt	p.S235I	SEC24C_ENST00000345254.4_Missense_Mutation_p.S235I|SEC24C_ENST00000411652.2_Missense_Mutation_p.S93I|SEC24C_ENST00000546025.1_Missense_Mutation_p.S93I|SEC24C_ENST00000540668.1_Intron|SEC24C_ENST00000535742.1_Intron	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	235					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					CCTGGACAGAGTTTTGGAGGG	0.642000													29	37					1.08312e-15	1.18619e-15	1	1	0
ZNF286B	729288	broad.mit.edu	37	17	18566500	18566500	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18566500G>A	ENST00000545289.1	-	5	569	c.319C>T	c.(319-321)Cat>Tat	p.H107Y		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						CATTGGAAATGCAAATTTCCT	0.393000													15	31					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64665161	64665161	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64665161G>A	ENST00000421419.2	-	36	5169	c.5055C>T	c.(5053-5055)caC>caT	p.H1685H	ATG2A_ENST00000377264.3_Silent_p.H1683H			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1683							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						CCATCGTGACGTGCTTGCCAT	0.627000													20	22					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15271812	15271812	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:15271812C>T	ENST00000263388.2	-	33	6702	c.6627G>A	c.(6625-6627)ccG>ccA	p.P2209P		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	2209					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CCAGGTAAGGCGGGGGCCGCT	0.731000													4	2					0	0	1	0	0
COG8	84342	broad.mit.edu	37	16	69369129	69369129	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:69369129G>A	ENST00000306875.4	-	3	822	c.708C>T	c.(706-708)gaC>gaT	p.D236D	COG8_ENST00000562081.1_Silent_p.D236D|RP11-343C2.9_ENST00000563634.1_Silent_p.D111D	NM_032382.4	NP_115758.3	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	236					protein transport	Golgi membrane|Golgi transport complex				breast(3)|kidney(1)|large_intestine(2)|ovary(2)|skin(1)	9						CAGTGAAGACGTCCATGCGCC	0.557000													3	11					0	0	1	0	0
ZBTB2	57621	broad.mit.edu	37	6	151686671	151686671	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:151686671G>A	ENST00000325144.4	-	3	1670	c.1530C>T	c.(1528-1530)acC>acT	p.T510T		NM_020861.1	NP_065912.1	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	510					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|skin(1)	12			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		CTAGTAAGACGGTTTCTTGTT	0.448000													50	79					0	0	1	0	0
SH2D3A	10045	broad.mit.edu	37	19	6760819	6760819	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6760819C>T	ENST00000245908.6	-	3	518	c.249G>A	c.(247-249)gaG>gaA	p.E83E	SH2D3A_ENST00000599563.1_5'UTR|SH2D3A_ENST00000437152.3_Intron	NM_005490.2	NP_005481.2	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	83	SH2.				JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|urinary_tract(1)	24						TGGGGAATTGCTCATCCTCCA	0.642000													34	44					0	0	1	0	0
DIS3L2	129563	broad.mit.edu	37	2	233001355	233001355	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:233001355G>A	ENST00000360410.4	+	9	1211	c.935G>A	c.(934-936)gGc>gAc	p.G312D	DIS3L2_ENST00000325385.7_Silent_p.R292R|DIS3L2_ENST00000273009.6_Silent_p.R292R|DIS3L2_ENST00000409307.1_Silent_p.R292R			Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like 2	0							exonuclease activity|ribonuclease activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(2)|urinary_tract(1)	40		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		TTGTGGCACGGCCTAAAGATT	0.507000													40	57					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925441	27925441	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:27925441C>T	ENST00000244623.1	+	1	423	c.423C>T	c.(421-423)tgC>tgT	p.C141C		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C141*(1)		endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						AGAGACTCTGCCTCCAGTTGG	0.498000													46	77					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139391156	139391156	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139391156G>A	ENST00000277541.6	-	34	7110	c.7035C>T	c.(7033-7035)ggC>ggT	p.G2345G		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	2345					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGCCTACCATGCCATGCTGCA	0.687000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			10	45					0	0	1	0	0
LGALS4	3960	broad.mit.edu	37	19	39303130	39303130	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39303130G>A	ENST00000307751.4	-	2	552	c.75C>T	c.(73-75)ggC>ggT	p.G25G	LGALS4_ENST00000597803.1_5'UTR	NM_006149.3	NP_006140.1	P56470	LEG4_HUMAN	lectin, galactoside-binding, soluble, 4	25	Galectin 1.				cell adhesion	cytosol|plasma membrane	sugar binding			NS(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	17	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CGTTGAGCCCGCCCGGGATGG	0.607000													9	19					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294511	25294511	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:25294511C>T	ENST00000400358.4	+	19	2652	c.2595C>T	c.(2593-2595)agC>agT	p.S865S	SGSM1_ENST00000400359.4_Silent_p.S920S	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	920	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						TGTCTTCCAGCGGCGTCACCT	0.547000													30	45					0	0	1	0	0
RNF24	0	broad.mit.edu	37	20	3915668	3915668	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:3915668C>T	ENST00000336095.5	-	5	532	c.281G>A	c.(280-282)tGc>tAc	p.C94Y	RNF24_ENST00000545616.1_Missense_Mutation_p.C115Y|RNF24_ENST00000358395.6_Missense_Mutation_p.C94Y|RNF24_ENST00000432261.2_Missense_Mutation_p.C115Y	NM_007219.3	NP_009150.1	Q9Y225	RNF24_HUMAN	ring finger protein 24	94						Golgi membrane|integral to membrane	zinc ion binding			large_intestine(1)|upper_aerodigestive_tract(1)	2						CTTACATGGGCAAATCCCCAA	0.448000													9	25					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16945567	16945567	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16945567G>A	ENST00000412962.1	-	0	1952																											CTCTGACAGCGCCATCTTCTC	0.622000													26	266					0	0	1	0	0
SPATA5	166378	broad.mit.edu	37	4	123850197	123850197	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:123850197G>A	ENST00000274008.3	+	3	360	c.291G>A	c.(289-291)gtG>gtA	p.V97V	SPATA5_ENST00000422835.2_3'UTR	NM_145207.2	NP_660208.2	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	97					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						TCTGGCAGGTGTATACAGCCT	0.433000													9	11					0	0	1	0	0
RBFOX2	23543	broad.mit.edu	37	22	36146495	36146495	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36146495C>T	ENST00000359369.4	-	11	957	c.874G>A	c.(874-876)Gca>Aca	p.A292T	RBFOX2_ENST00000438146.2_Intron|RBFOX2_ENST00000414461.2_Intron|RBFOX2_ENST00000397303.2_Intron|RBFOX2_ENST00000449924.2_Intron|RBFOX2_ENST00000416721.2_Intron|RBFOX2_ENST00000262829.7_Intron|RBFOX2_ENST00000405409.2_Intron			O43251	RFOX2_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 2	232	Ala-rich.				estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding			endometrium(4)|large_intestine(7)|lung(7)	18						AAGCAGTTTGCAGATTCTATC	0.388000													3	17					0	0	1	0	0
ARHGEF40	55701	broad.mit.edu	37	14	21543039	21543039	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:21543039C>T	ENST00000298694.4	+	3	1277	c.1150C>T	c.(1150-1152)Cga>Tga	p.R384*	ARHGEF40_ENST00000298693.3_Nonsense_Mutation_p.R384*			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	384	Gly-rich.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						AAGAAAGAAGCGAGCTGCAGG	0.617000													12	22					0	0	1	0	0
CS	1431	broad.mit.edu	37	12	56667535	56667535	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56667535G>A	ENST00000548567.1	-	11	1338	c.868C>T	c.(868-870)Cga>Tga	p.R290*	CS_ENST00000542324.2_Nonsense_Mutation_p.R343*|CS_ENST00000351328.3_Nonsense_Mutation_p.R356*			O75390	CISY_HUMAN	citrate synthase	356					cellular carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	citrate (Si)-synthase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	17		Myeloproliferative disorder(1001;0.000374)		BRCA - Breast invasive adenocarcinoma(357;6.17e-07)		CAGGTATATCGCGGATCAGTC	0.423000													20	63					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58060841	58060841	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:58060841A>G	ENST00000556826.1	-	2	341	c.103_splice	c.e2-1	p.S35_splice	SLC35F4_ENST00000557430.1_5'UTR|SLC35F4_ENST00000339762.6_Splice_Site_p.G71_splice|SLC35F4_ENST00000554729.1_5'UTR	NM_001206920.1	NP_001193849.1			solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ATCTGGAGGTACCTGGAAAGA	0.438000													9	24					0	0	1	0	0
VILL	50853	broad.mit.edu	37	3	38048184	38048184	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38048184G>A	ENST00000283713.6	+	19	2716	c.2450G>A	c.(2449-2451)cGc>cAc	p.R817H	VILL_ENST00000383759.2_Missense_Mutation_p.R817H|VILL_ENST00000465644.1_Missense_Mutation_p.R535H			O15195	VILL_HUMAN	villin-like	817	HP.				actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|urinary_tract(2)	28				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		GACCCTGCCCGCAGGGAGGTG	0.672000													9	22					0	0	1	0	0
NUBP1	4682	broad.mit.edu	37	16	10841067	10841067	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:10841067C>T	ENST00000283027.5	+	3	211	c.192C>T	c.(190-192)ggC>ggT	p.G64G	NUBP1_ENST00000433392.2_Silent_p.G64G|NUBP1_ENST00000571790.1_3'UTR	NM_002484.2	NP_002475.2	P53384	NUBP1_HUMAN	nucleotide binding protein 1	64					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			large_intestine(2)|lung(3)|ovary(1)|skin(4)	10						CTGGGAAAGGCGGTGTTGGGA	0.463000													23	37					0	0	1	0	0
DKKL1	27120	broad.mit.edu	37	19	49869055	49869055	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49869055C>T	ENST00000221498.2	+	4	735	c.330C>T	c.(328-330)acC>acT	p.T110T	DKKL1_ENST00000594268.1_Intron	NM_014419.3	NP_055234.1	Q9UK85	DKKL1_HUMAN	dickkopf-like 1	110					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity			large_intestine(2)|upper_aerodigestive_tract(1)	3		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		CACAGATGACCGACAACAAGA	0.567000													3	24					0	0	1	0	0
EHD3	30845	broad.mit.edu	37	2	31484534	31484534	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:31484534G>A	ENST00000322054.5	+	5	1320	c.1035G>A	c.(1033-1035)gaG>gaA	p.E345E	EHD3_ENST00000541626.1_Intron	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	345					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					TCGAGCGGGAGCACCAGATCT	0.582000													27	35					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137363356	137363356	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:137363356C>T	ENST00000424189.2	-	3	782	c.553G>A	c.(553-555)Gtc>Atc	p.V185I	DGKI_ENST00000288490.5_Missense_Mutation_p.V185I|DGKI_ENST00000446122.1_Missense_Mutation_p.V185I|DGKI_ENST00000453654.1_5'UTR			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	185					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						TCTCCCGAGACGTTGGTCTCC	0.507000													61	81					0	0	1	0	0
GIGYF1	64599	broad.mit.edu	37	7	100281031	100281031	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100281031G>A	ENST00000275732.5	-	18	3298	c.2089C>T	c.(2089-2091)Cgg>Tgg	p.R697W		NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	697										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TCTTCCTCCCGCTTCGCCCTG	0.657000													79	92					0	0	1	0	0
CHMP5	51510	broad.mit.edu	37	9	33265135	33265135	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:33265135G>A	ENST00000419016.2	+	1	99	c.59G>A	c.(58-60)tGc>tAc	p.C20Y	CHMP5_ENST00000223500.8_Missense_Mutation_p.C20Y	NM_001195536.1	NP_001182465.1	Q9NZZ3	CHMP5_HUMAN	charged multivesicular body protein 5	20					cellular membrane organization|protein transport	cytosol|endosome membrane	protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)	10			LUSC - Lung squamous cell carcinoma(29;0.00506)			CTGACTGACTGCATTGGCACG	0.582000													31	55					0	0	1	0	0
TMEM69	51249	broad.mit.edu	37	1	46156748	46156748	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:46156748G>A	ENST00000372025.4	+	2	1165	c.8G>A	c.(7-9)cGc>cAc	p.R3H	TMEM69_ENST00000496366.1_Intron	NM_016486.3	NP_057570.2	Q5SWH9	TMM69_HUMAN	transmembrane protein 69	3						integral to membrane				kidney(3)|lung(4)|ovary(1)	8	Acute lymphoblastic leukemia(166;0.155)					AGTATGCTTCGCTTCATCCAG	0.438000													23	40					0	0	1	0	0
GOLGA6L7P	0	broad.mit.edu	37	15	29092305	29092305	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:29092305C>T	ENST00000569815.1	-	0	210					NR_047567.1																						CCGGTACCAACACCAGCACTG	0.473000													4	5					0	0	1	0	0
CHID1	66005	broad.mit.edu	37	11	883189	883189	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:883189G>A	ENST00000449825.1	-	10	1274	c.918C>T	c.(916-918)taC>taT	p.Y306Y	CHID1_ENST00000528581.1_Silent_p.Y331Y|CHID1_ENST00000323578.8_Silent_p.Y306Y|CHID1_ENST00000436108.2_Silent_p.Y306Y|CHID1_ENST00000336845.5_Silent_p.Y331Y|CHID1_ENST00000454838.2_Silent_p.Y331Y|CHID1_ENST00000429789.2_Silent_p.Y275Y|CHID1_ENST00000526714.1_5'UTR|CHID1_ENST00000323541.7_Silent_p.Y336Y	NM_001142675.1	NP_001136147.1	Q9BWS9	CHID1_HUMAN	chitinase domain containing 1	306					chitin catabolic process|innate immune response	extracellular region|lysosome	cation binding|chitinase activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	13		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.48e-25)|Epithelial(43;3.75e-24)|BRCA - Breast invasive adenocarcinoma(625;4.65e-05)|Lung(200;0.0624)|LUSC - Lung squamous cell carcinoma(625;0.0735)		TGGAGGTCGCGTAGTCCATAC	0.637000													36	71					0	0	1	0	0
EGLN3	112399	broad.mit.edu	37	14	34419698	34419698	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:34419698G>A	ENST00000547327.2	-	1	589	c.261C>T	c.(259-261)ggC>ggT	p.G87G	EGLN3_ENST00000553215.1_Intron|EGLN3_ENST00000250457.3_Silent_p.G87G			Q9H6Z9	EGLN3_HUMAN	egl-9 family hypoxia-inducible factor 3	87					apoptosis	cytoplasm|nucleus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|upper_aerodigestive_tract(1)	15	Breast(36;0.0303)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.000246)|Lung(238;0.000959)|Epithelial(34;0.155)	GBM - Glioblastoma multiforme(112;0.0118)	Vitamin C(DB00126)	TGGCCTCGCAGCCCTCCTCGT	0.682000													11	30					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872892	55872892	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55872892C>T	ENST00000313503.1	+	1	374	c.374C>T	c.(373-375)gCg>gTg	p.A125V		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					CGCTATGCAGCGATCTGCAGT	0.468000										HNSCC(53;0.14)			4	79					0	0	1	0	0
NF2	4771	broad.mit.edu	37	22	30035131	30035131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:30035131C>T	ENST00000338641.4	+	3	734	c.293C>T	c.(292-294)gCc>gTc	p.A98V	NF2_ENST00000397789.3_Missense_Mutation_p.A98V|NF2_ENST00000403435.1_Missense_Mutation_p.A98V|NF2_ENST00000361166.4_Missense_Mutation_p.A98V|NF2_ENST00000413209.2_Missense_Mutation_p.A98V|NF2_ENST00000361452.4_Intron|NF2_ENST00000347330.5_Intron|NF2_ENST00000403999.3_Missense_Mutation_p.A98V|NF2_ENST00000353887.4_Intron|NF2_ENST00000361676.4_Missense_Mutation_p.A56V|NF2_ENST00000334961.7_Intron	NM_000268.3|NM_016418.5|NM_181832.2	NP_000259.1|NP_057502.2|NP_861970.1	P35240	MERL_HUMAN	neurofibromin 2 (merlin)	98	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(3)|p.V86_Q111>E(1)|p.L97fs*22(1)|p.H84_F100del(1)|p.L97fs*17(1)|p.H95fs*3(1)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						CACTTCTTGGCCAAATTTTAT	0.428000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2				12	67					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31917883	31917883	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31917883G>A	ENST00000456570.1	+	23	3026	c.2971G>A	c.(2971-2973)Gat>Aat	p.D991N	CFB_ENST00000425368.2_Missense_Mutation_p.D489N|CFB_ENST00000477310.1_Missense_Mutation_p.D840N|CFB_ENST00000556679.1_Missense_Mutation_p.D991N			P00751	CFAB_HUMAN	complement factor B	489					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						GAAGGGTACCGATTACCACAA	0.502000													29	42					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129218783	129218783	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:129218783G>A	ENST00000296266.3	+	20	2592	c.2400G>A	c.(2398-2400)atG>atA	p.M800I	IFT122_ENST00000349441.2_Missense_Mutation_p.M638I|IFT122_ENST00000347300.2_Missense_Mutation_p.M690I|IFT122_ENST00000348417.2_Missense_Mutation_p.M749I|IFT122_ENST00000440957.2_Missense_Mutation_p.M540I|IFT122_ENST00000504021.1_Missense_Mutation_p.M625I|IFT122_ENST00000507564.1_Missense_Mutation_p.M741I|IFT122_ENST00000513932.1_3'UTR|IFT122_ENST00000431818.2_Missense_Mutation_p.M599I	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	749					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						AAACAAAGATGCTAATCACCA	0.493000													39	41					0	0	1	0	0
B4GALNT4	338707	broad.mit.edu	37	11	380447	380447	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:380447T>C	ENST00000329962.6	+	18	2869		c.e18+2			NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4							Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACCCCCACGGTGAGGCCCCGA	0.701000													6	6					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100654441	100654441	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:100654441C>A	ENST00000358544.2	+	34	5809	c.5698C>A	c.(5698-5700)Ctc>Atc	p.L1900I	VPS13B_ENST00000357162.2_Missense_Mutation_p.L1875I|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1900					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGCAGAAGATCTCTTAAGGAG	0.418000													21	68					2.37509e-13	2.57931e-13	1	1	0
MAPK8IP3	23162	broad.mit.edu	37	16	1793343	1793343	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1793343C>T	ENST00000250894.4	+	5	767	c.610C>T	c.(610-612)Cgc>Tgc	p.R204C	MAPK8IP3_ENST00000356010.5_Missense_Mutation_p.R204C	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	204					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						CAGGAAGGAGCGCCCCACCTC	0.642000													17	20					0	0	1	0	0
UBXN1	51035	broad.mit.edu	37	11	62445452	62445452	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62445452C>T	ENST00000294119.2	-	5	560	c.429G>A	c.(427-429)atG>atA	p.M143I	UBXN1_ENST00000301935.5_Missense_Mutation_p.M143I|UBXN1_ENST00000533000.1_Start_Codon_SNP_p.M1I|UBXN1_ENST00000524762.1_5'UTR|UBXN1_ENST00000529640.1_Missense_Mutation_p.M143I	NM_015853.3	NP_056937.2	Q04323	UBXN1_HUMAN	UBX domain protein 1	143	Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding			endometrium(5)|lung(12)	17						CAGCCCGGCGCATCTCATCTT	0.567000													9	19					0	0	1	0	0
POLR1B	84172	broad.mit.edu	37	2	113333173	113333173	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:113333173G>A	ENST00000263331.5	+	15	3855	c.3275G>A	c.(3274-3276)cGc>cAc	p.R1092H	POLR1B_ENST00000541869.1_Missense_Mutation_p.R1130H|POLR1B_ENST00000417433.2_Missense_Mutation_p.R1036H|POLR1B_ENST00000537335.1_Missense_Mutation_p.R881H|POLR1B_ENST00000409894.3_Missense_Mutation_p.R909H	NM_019014.4	NP_061887.2	Q9H9Y6	RPA2_HUMAN	polymerase (RNA) I polypeptide B, 128kDa	1092					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding	p.R1092H(1)		breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						TCTGCCATGCGCAACAGAAAA	0.478000													19	72					0	0	1	0	0
GBA	2629	broad.mit.edu	37	1	155206159	155206159	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155206159G>A	ENST00000428024.2	-	7	1342	c.840C>T	c.(838-840)caC>caT	p.H280H	GBA_ENST00000368373.3_Silent_p.H367H|GBA_ENST00000327247.5_Silent_p.H367H|GBA_ENST00000427500.2_Silent_p.H318H|GBA_ENST00000536770.1_Silent_p.H254H	NM_001171811.1	NP_001165282.1	P04062	GLCM_HUMAN	glucosidase, beta, acid	367					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	26	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	GGAACAGGCGGTGTGTCTCCC	0.562000									Gaucher disease type I				5	25					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2552882	2552882	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:2552882G>T	ENST00000358864.1	+	5	627	c.612G>T	c.(610-612)aaG>aaT	p.K204N		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	204	Arg/Asp/Glu/Lys-rich (highly charged).					integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						GGAAAGGCAAGCAACTATATG	0.493000													16	26					3.99206e-14	4.34914e-14	1	1	0
KIF19	124602	broad.mit.edu	37	17	72347026	72347026	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72347026G>A	ENST00000389916.4	+	12	1707	c.1569G>A	c.(1567-1569)aaG>aaA	p.K523K	AC103809.2_ENST00000599136.1_Silent_p.C95C	NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	523					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						ACGAGCAGAAGCAACTGCGCA	0.622000													29	48					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610471	47610471	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47610471C>T	ENST00000371890.3	+	7	793	c.757C>T	c.(757-759)Ccc>Tcc	p.P253S	CYP4A22_ENST00000485117.1_3'UTR|CYP4A22_ENST00000371891.3_Intron|CYP4A22_ENST00000294337.3_Intron|CYP4A22-AS1_ENST00000444042.2_lincRNA			Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	510						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CCCTGGTCTGCCCAGGCCTTG	0.587000													9	4					0	0	1	0	0
NR2C1	7181	broad.mit.edu	37	12	95456330	95456330	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:95456330T>C	ENST00000333003.5	-	3	569	c.239A>G	c.(238-240)aAc>aGc	p.N80S	NR2C1_ENST00000393101.3_Missense_Mutation_p.N80S|NR2C1_ENST00000545833.1_5'UTR|NR2C1_ENST00000330677.7_Missense_Mutation_p.N80S	NM_003297.3	NP_003288.2	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	80	Required for interaction with KAT2B (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)	13						AAATAACTGGTTGACACCTGC	0.398000													12	17					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116429262	116429262	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:116429262G>A	ENST00000281928.3	-	17	3703	c.3497C>T	c.(3496-3498)gCg>gTg	p.A1166V		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1166					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GTTCATAATCGCACTAAACCC	0.473000													40	56					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117182148	117182148	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:117182148G>A	ENST00000003084.6	+	9	1327	c.1195G>A	c.(1195-1197)Gcc>Acc	p.A399T	CFTR_ENST00000454343.1_Missense_Mutation_p.A399T	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	399					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GAATGTAACAGCCTTCTGGGA	0.318000									Cystic Fibrosis				20	27					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69696393	69696393	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:69696393C>A	ENST00000265403.7	+	6	1410	c.1383C>A	c.(1381-1383)ttC>ttA	p.F461L	UGT2B10_ENST00000458688.2_Missense_Mutation_p.F377L	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	461					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						GAGCAGTCTTCTGGATTGAAT	0.418000													59	89					1.33661e-31	1.49889e-31	1	1	0
CTSW	1521	broad.mit.edu	37	11	65649991	65649991	+	Missense_Mutation	SNP	G	G	A	rs140048610		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65649991G>A	ENST00000528419.1	+	5	536	c.532G>A	c.(532-534)Gtg>Atg	p.V178M	CTSW_ENST00000307886.3_Missense_Mutation_p.V178M			P56202	CATW_HUMAN	cathepsin W	178					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(5)	9				READ - Rectum adenocarcinoma(159;0.168)		GGATGTCTCCGTGCAGGGTAG	0.607000													15	22					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128391775	128391775	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128391775C>T	ENST00000389524.4	+	40	5514	c.5461C>T	c.(5461-5463)Cgg>Tgg	p.R1821W	MYO7B_ENST00000428314.1_Missense_Mutation_p.R1820W|MYO7B_ENST00000409816.2_Missense_Mutation_p.R1820W|MYO7B_ENST00000409090.1_Missense_Mutation_p.R673W			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1820	FERM 2.|MyTH4 3.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGCCAACACACGGGTGCGGGA	0.637000													3	4					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904809	55904809	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55904809G>A	ENST00000301529.1	-	1	385	c.386C>T	c.(385-387)cCt>cTt	p.P129L		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					GTAGAGCAGAGGGTTACAAAT	0.512000													20	61					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169474577	169474577	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:169474577G>A	ENST00000256935.8	+	40	4110	c.4030G>A	c.(4030-4032)Gct>Act	p.A1344T	DOCK2_ENST00000520908.1_Missense_Mutation_p.A836T|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Missense_Mutation_p.A405T	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1344	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGACTACTTTGCTGTTGGATA	0.522000													24	38					0	0	1	0	0
TET2	54790	broad.mit.edu	37	4	106156139	106156139	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:106156139C>T	ENST00000513237.1	+	3	1900	c.1103C>T	c.(1102-1104)gCg>gTg	p.A368V	TET2_ENST00000413648.2_Missense_Mutation_p.A347V|TET2_ENST00000545826.1_Missense_Mutation_p.A347V|TET2_ENST00000394764.1_Missense_Mutation_p.A347V|TET2_ENST00000305737.2_Missense_Mutation_p.A347V|TET2_ENST00000540549.1_Missense_Mutation_p.A347V|TET2_ENST00000380013.4_Missense_Mutation_p.A347V			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	347					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		ACAAAGCTAGCGTCTGGTGAA	0.413000			"""Mis N, F"""		MDS								15	28					0	0	1	0	0
IGFBP1	3484	broad.mit.edu	37	7	45932601	45932601	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:45932601G>A	ENST00000275525.3	+	4	987	c.691G>A	c.(691-693)Gtc>Atc	p.V231I	IGFBP1_ENST00000468955.1_Missense_Mutation_p.V188I|IGFBP1_ENST00000457280.1_Missense_Mutation_p.V229I	NM_000596.2	NP_000587.1	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	231	Thyroglobulin type-1.					extracellular space	insulin-like growth factor binding			large_intestine(2)|lung(4)	6						CTGCTGGTGCGTCTACCCTTG	0.498000													21	30					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82456574	82456574	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:82456574G>A	ENST00000370728.1	+	25	4770	c.4125G>A	c.(4123-4125)atG>atA	p.M1375I	LPHN2_ENST00000359929.3_Missense_Mutation_p.M1319I|LPHN2_ENST00000370730.1_Missense_Mutation_p.M1332I|LPHN2_ENST00000319517.6_Missense_Mutation_p.M1319I|LPHN2_ENST00000335786.5_Missense_Mutation_p.M1332I|LPHN2_ENST00000370723.1_Missense_Mutation_p.M1377I|LPHN2_ENST00000469377.2_3'UTR|LPHN2_ENST00000394879.1_Missense_Mutation_p.M1377I|LPHN2_ENST00000370721.1_Missense_Mutation_p.M1300I|LPHN2_ENST00000370713.1_3'UTR|LPHN2_ENST00000370727.1_Missense_Mutation_p.M1347I|LPHN2_ENST00000370717.2_Missense_Mutation_p.M1390I|LPHN2_ENST00000370715.1_3'UTR|LPHN2_ENST00000271029.4_Missense_Mutation_p.M1347I|LPHN2_ENST00000370725.1_Missense_Mutation_p.M1390I			O95490	LPHN2_HUMAN	latrophilin 2	1375					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ATACAAGCATGCCCAATCTTA	0.493000													15	29					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98645159	98645159	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:98645159C>T	ENST00000261574.5	+	10	917	c.737C>T	c.(736-738)tCg>tTg	p.S246L	IPO5_ENST00000539640.1_Missense_Mutation_p.S103L|IPO5_ENST00000490680.1_Missense_Mutation_p.S228L	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	228					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						GTAAATGACTCGTGCTACCAG	0.408000													32	54					0	0	1	0	0
WDR76	79968	broad.mit.edu	37	15	44149354	44149354	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:44149354G>A	ENST00000263795.6	+	10	1472	c.1402G>A	c.(1402-1404)Gga>Aga	p.G468R	WDR76_ENST00000381246.2_Missense_Mutation_p.G404R	NM_001167941.1|NM_024908.3	NP_001161413.1|NP_079184.2	Q9H967	WDR76_HUMAN	WD repeat domain 76	468										breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)	20		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		TATCACTGCCGGATTGAGGTA	0.343000													20	40					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11063092	11063092	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:11063092G>A	ENST00000409790.1	+	4	648	c.418G>A	c.(418-420)Gcc>Acc	p.A140T	CLEC16A_ENST00000409552.3_Missense_Mutation_p.A140T	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	140										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GGAGATTATGGCCTATTATAT	0.348000													15	22					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95571527	95571527	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:95571527T>C	ENST00000526495.1	-	22	3441	c.3150A>G	c.(3148-3150)aaA>aaG	p.K1050K	DICER1_ENST00000343455.3_Silent_p.K1050K|DICER1_ENST00000556045.1_5'UTR|DICER1_ENST00000393063.1_Silent_p.K1050K|DICER1_ENST00000527414.1_Silent_p.K1050K|DICER1_ENST00000541352.1_Silent_p.K1050K			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1050					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GACAAACAGCTTTTCTCCACA	0.478000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				45	69					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113350345	113350345	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:113350345C>T	ENST00000458497.1	+	10	1115	c.836C>T	c.(835-837)gCa>gTa	p.A279V	ALPK1_ENST00000504176.2_Missense_Mutation_p.A201V|ALPK1_ENST00000177648.9_Missense_Mutation_p.A279V	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	279							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		CTGTCCGCTGCAGAAGCCTGC	0.517000													61	102					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36641108	36641108	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:36641108C>T	ENST00000373448.2	-	3	1349	c.1111G>A	c.(1111-1113)Gct>Act	p.A371T	TTI1_ENST00000487362.1_Intron|TTI1_ENST00000373447.3_Missense_Mutation_p.A371T|TTI1_ENST00000449821.1_Missense_Mutation_p.A371T	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	371							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						AAGATGTCAGCGAGGGCTTTG	0.458000													47	69					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49724057	49724057	+	Silent	SNP	C	C	T	rs112602380		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:49724057C>T	ENST00000303221.5	-	2	332	c.117G>A	c.(115-117)tcG>tcA	p.S39S	EMB_ENST00000514111.1_5'UTR|EMB_ENST00000506190.1_5'UTR|EMB_ENST00000508934.1_Silent_p.S39S	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	39						integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TTGTAAAAGGCGAATCTATAA	0.328000													12	23					0	0	1	0	0
NDUFA5	4698	broad.mit.edu	37	7	123190561	123190561	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:123190561T>G	ENST00000471770.1	-	3	280	c.146A>C	c.(145-147)gAa>gCa	p.E49A	NDUFA5_ENST00000355749.2_Missense_Mutation_p.E49A|NDUFA5_ENST00000467117.1_5'UTR			Q16718	NDUA5_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5	49					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			large_intestine(1)|urinary_tract(1)	2					NADH(DB00157)	TGTAATCTGTTCTGTATACTT	0.333000													4	119					0	0	1	0	0
LHX4	89884	broad.mit.edu	37	1	180235529	180235529	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:180235529G>A	ENST00000263726.2	+	3	495	c.251G>A	c.(250-252)cGc>cAc	p.R84H		NM_033343.3	NP_203129.1	Q969G2	LHX4_HUMAN	LIM homeobox 4	84	LIM zinc-binding 1.		R -> C (in CPHD4; has impaired activity on CGA, POU1F1 and TSHB promoters but exhibits normal DNA binding to the CGA pituitary glycoprotein basal element (PGBE) and interaction with the POU1F1 protein).			nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)	16						CCTGACAGGCGCTTCGGCACA	0.622000													24	30					0	0	1	0	0
EFHC1	114327	broad.mit.edu	37	6	52357121	52357121	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:52357121T>C	ENST00000371068.5	+	11	2008	c.1905T>C	c.(1903-1905)gtT>gtC	p.V635V	EFHC1_ENST00000538167.1_Silent_p.V616V|EFHC1_ENST00000433625.2_Intron	NM_018100.3	NP_060570.2	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	635						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	27	Lung NSC(77;0.109)					ATAACTTTGTTCGTGCTTTCT	0.398000													17	87					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59282165	59282165	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:59282165G>A	ENST00000320743.3	-	7	1179	c.893C>T	c.(892-894)gCc>gTc	p.A298V	LRIG3_ENST00000379141.4_Missense_Mutation_p.A238V	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	298						integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			CCTGTTGATGGCATTTTGGCT	0.483000			T	ROS1	NSCLC								23	29					0	0	1	0	0
UMPS	7372	broad.mit.edu	37	3	124456654	124456654	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:124456654G>A	ENST00000232607.2	+	3	656	c.550G>A	c.(550-552)Gag>Aag	p.E184K	UMPS_ENST00000413078.2_Missense_Mutation_p.E6K|UMPS_ENST00000538242.1_Missense_Mutation_p.E6K|UMPS_ENST00000536109.1_Missense_Mutation_p.E92K|UMPS_ENST00000498715.1_3'UTR	NM_000373.3	NP_000364.1	P11172	UMPS_HUMAN	uridine monophosphate synthetase	184	OPRTase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(114;0.146)		GGAGATTCTCGAGCAGCAGAA	0.498000													20	12					0	0	1	0	0
TADA2B	93624	broad.mit.edu	37	4	7056103	7056103	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:7056103C>T	ENST00000310074.7	+	2	774	c.585C>T	c.(583-585)gaC>gaT	p.D195D	TADA2B_ENST00000512388.1_Silent_p.D120D|TADA2B_ENST00000515646.1_Silent_p.D103D	NM_152293.2	NP_689506.2	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2B	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding			breast(3)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	18						ATGATGACGACGACGTGGAGA	0.577000													17	28					0	0	1	0	0
STMN3	50861	broad.mit.edu	37	20	62272715	62272715	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:62272715C>T	ENST00000370053.1	-	5	600	c.519G>A	c.(517-519)gaG>gaA	p.E173E	STMN3_ENST00000540534.1_Silent_p.E162E	NM_001276310.1|NM_015894.2	NP_001263239.1|NP_056978.2	Q9NZ72	STMN3_HUMAN	stathmin-like 3	173					cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding			kidney(1)|large_intestine(1)|lung(5)|prostate(1)	8	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			CTTCTCGCTGCTCCTTGTTCC	0.667000													4	1					0	0	1	0	0
CHIAP2	0	broad.mit.edu	37	1	111824404	111824404	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:111824404C>A	ENST00000369743.4	+	0	288					NR_003928.1																						AGTTTCAAATCTTTTAACCTT	0.393000													7	5					2.0095e-06	2.09073e-06	1	1	0
GARNL3	84253	broad.mit.edu	37	9	130111298	130111298	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130111298C>T	ENST00000373387.4	+	17	1879	c.1527C>T	c.(1525-1527)ggC>ggT	p.G509G	GARNL3_ENST00000435213.2_Silent_p.G487G|GARNL3_ENST00000314904.5_Silent_p.G509G	NM_032293.4	NP_115669.3	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	509	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						CTGATGCTGGCGTCTTGCTAG	0.507000													8	28					0	0	1	0	0
PTF1A	256297	broad.mit.edu	37	10	23482762	23482762	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:23482762A>G	ENST00000376504.3	+	2	1118	c.914A>G	c.(913-915)gAc>gGc	p.D305G		NM_178161.2	NP_835455.1	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	305					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						ACCCCAGAGGACCCCAGAAAA	0.473000													30	76					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	26917902	26917902	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:26917902C>T	ENST00000539517.2	-	5	1104	c.787G>A	c.(787-789)Gca>Aca	p.A263T	NOVA1_ENST00000465357.2_Missense_Mutation_p.A239T|NOVA1_ENST00000267422.7_Missense_Mutation_p.A141T	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	266					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		TTGGAATTTGCCACTGGACCT	0.463000													30	46					0	0	1	0	0
STX1A	6804	broad.mit.edu	37	7	73123392	73123392	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:73123392C>T	ENST00000222812.3	-	2	117	c.91G>A	c.(91-93)Gat>Aat	p.D31N	STX1A_ENST00000395156.3_Missense_Mutation_p.D31N|STX1A_ENST00000395154.3_Missense_Mutation_p.D31N|STX1A_ENST00000395155.3_Missense_Mutation_p.D31N	NM_004603.3	NP_004594.1	Q16623	STX1A_HUMAN	syntaxin 1A (brain)	31					energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity			large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	5		Lung NSC(55;0.0908)|all_lung(88;0.198)				AAGAACTCATCCATGAAGCGG	0.587000													47	55					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126241756	126241756	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126241756G>A	ENST00000394329.3	+	1	4203	c.4190G>A	c.(4189-4191)aGa>aAa	p.R1397K		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1397	Cadherin 13.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GACCAAGGAAGACCTCCTCGT	0.378000													45	80					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123601449	123601449	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:123601449G>A	ENST00000336139.4	-	3	510	c.148C>T	c.(148-150)Cga>Tga	p.R50*	ZNF202_ENST00000529691.1_Nonsense_Mutation_p.R50*|ZNF202_ENST00000530393.1_Nonsense_Mutation_p.R50*			O95125	ZN202_HUMAN	zinc finger protein 202	50	SCAN box.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CGGAAGCGTCGGAAGTTCTGG	0.547000													10	49					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152749493	152749493	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152749493G>A	ENST00000367255.5	-	37	5424	c.4823C>T	c.(4822-4824)gCg>gTg	p.A1608V	SYNE1_ENST00000367253.4_Missense_Mutation_p.A1608V|SYNE1_ENST00000448038.1_Missense_Mutation_p.A1615V|SYNE1_ENST00000341594.5_Missense_Mutation_p.A1678V|SYNE1_ENST00000423061.1_Missense_Mutation_p.A1615V|SYNE1_ENST00000265368.4_Missense_Mutation_p.A1608V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1608					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.A1608V(2)		NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGCAGTGATCGCGCTGCTCAG	0.537000										HNSCC(10;0.0054)			13	25					0	0	1	0	0
HHAT	55733	broad.mit.edu	37	1	210847634	210847634	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:210847634G>A	ENST00000367010.1	+	12	1622	c.1395G>A	c.(1393-1395)tgG>tgA	p.W465*	HHAT_ENST00000537898.1_Nonsense_Mutation_p.W400*|HHAT_ENST00000367009.1_Nonsense_Mutation_p.W155*|HHAT_ENST00000308852.6_Nonsense_Mutation_p.W420*|HHAT_ENST00000545781.1_Nonsense_Mutation_p.W402*|HHAT_ENST00000545154.1_Nonsense_Mutation_p.W466*|HHAT_ENST00000541565.1_Nonsense_Mutation_p.W328*|HHAT_ENST00000413764.2_Nonsense_Mutation_p.W465*|HHAT_ENST00000261458.3_Nonsense_Mutation_p.W465*	NM_001170580.1	NP_001164051.1	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	465					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		CTGCAGGCTGGCCTTGGGTGA	0.587000													27	23					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92568221	92568221	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:92568221G>A	ENST00000298047.6	+	14	10074	c.10057G>A	c.(10057-10059)Gac>Aac	p.D3353N	FAT3_ENST00000409404.2_Missense_Mutation_p.D3353N|FAT3_ENST00000525166.1_Missense_Mutation_p.D3203N			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3353	Cadherin 31.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TATCAGTGAAGACGCCTTGGT	0.488000										TCGA Ovarian(4;0.039)			14	18					0	0	1	0	0
PHF1	5252	broad.mit.edu	37	6	33381025	33381025	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33381025G>T	ENST00000374516.3	+	5	661	c.390G>T	c.(388-390)gaG>gaT	p.E130D	PHF1_ENST00000374512.3_Missense_Mutation_p.E130D	NM_024165.2	NP_077084.1	O43189	PHF1_HUMAN	PHD finger protein 1	130					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19		Ovarian(999;0.0443)				GAGAGGGAGAGGGCACATCCT	0.562000													8	31					1.76689e-08	1.86465e-08	1	1	0
ARHGAP17	55114	broad.mit.edu	37	16	24953340	24953340	+	Silent	SNP	C	C	T	rs150261398		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:24953340C>T	ENST00000289968.6	-	16	1527	c.1458G>A	c.(1456-1458)gcG>gcA	p.A486A	ARHGAP17_ENST00000303665.5_Silent_p.A486A|ARHGAP17_ENST00000441763.2_3'UTR	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	486					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		CTTCCATCACCGCCATGCTAG	0.502000													29	50					0	0	1	0	0
POU1F1	5449	broad.mit.edu	37	3	87325526	87325526	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:87325526G>A	ENST00000350375.2	-	1	211	c.87C>T	c.(85-87)caC>caT	p.H29H	POU1F1_ENST00000560656.1_Silent_p.H29H|POU1F1_ENST00000344265.3_Silent_p.H29H	NM_000306.2	NP_000297.1	P28069	PIT1_HUMAN	POU class 1 homeobox 1	29					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(2)	18	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		CGGCAGCACTGTGATGCATTA	0.463000													18	39					0	0	1	0	0
PIPOX	51268	broad.mit.edu	37	17	27380057	27380057	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27380057G>A	ENST00000323372.4	+	3	709	c.383G>A	c.(382-384)cGt>cAt	p.R128H	PIPOX_ENST00000583215.1_3'UTR	NM_016518.2	NP_057602.2	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	128					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity			endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	CTGAAGCAACGTTTCCCAAAT	0.483000													31	39					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79733372	79733372	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:79733372G>A	ENST00000338008.5	+	3	1048	c.868G>A	c.(868-870)Gca>Aca	p.A290T	ZFYVE16_ENST00000510158.1_Missense_Mutation_p.A290T|ZFYVE16_ENST00000505560.1_Missense_Mutation_p.A290T	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	290					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		CATAACTGCCGCAGAATGTTT	0.393000													40	40					0	0	1	0	0
URGCP	55665	broad.mit.edu	37	7	43918563	43918563	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:43918563C>T	ENST00000336086.6	-	4	2606	c.370G>A	c.(370-372)Gac>Aac	p.D124N	URGCP_ENST00000447717.3_Missense_Mutation_p.D124N|URGCP_ENST00000443736.1_Missense_Mutation_p.D124N|URGCP_ENST00000453200.1_Missense_Mutation_p.D167N|URGCP_ENST00000402306.3_Missense_Mutation_p.D158N|URGCP_ENST00000497914.1_5'UTR|RP5-1165K10.1_ENST00000603700.1_Intron|URGCP_ENST00000223341.7_Missense_Mutation_p.D124N			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	167					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GAATAAATGTCGGCAGCAAGG	0.557000													24	28					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48567655	48567655	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:48567655T>C	ENST00000537810.1	-	29	3827	c.3223A>G	c.(3223-3225)Atg>Gtg	p.M1075V	FRYL_ENST00000507711.1_Missense_Mutation_p.M1075V|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000503238.1_Missense_Mutation_p.M1075V|FRYL_ENST00000358350.4_Missense_Mutation_p.M1075V			O94915	FRYL_HUMAN	FRY-like	1075					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						CTGAACAGCATAAATAGACTG	0.368000													11	43					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940342	144940342	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144940342G>A	ENST00000525985.1	-	2	7151	c.7080C>T	c.(7078-7080)gaC>gaT	p.D2360D				P58107	EPIPL_HUMAN	epiplakin 1	2360						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTAGGCCACGTCCACGGGCA	0.692000													16	251					0	0	1	0	0
CNOT6	57472	broad.mit.edu	37	5	180001094	180001094	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:180001094C>T	ENST00000393356.1	+	14	1992	c.1568C>T	c.(1567-1569)cCg>cTg	p.P523L	CNOT6_ENST00000261951.4_Missense_Mutation_p.P523L			Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	523					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|skin(1)	23	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)		AGTGGCTGCCCGCACCCCCTC	0.532000													39	44					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14804929	14804929	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:14804929A>G	ENST00000261170.3	-	14	1705	c.1569T>C	c.(1567-1569)ggT>ggC	p.G523G		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	523	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CAGTGAAATTACCATCATTGT	0.353000													22	35					0	0	1	0	0
ESM1	11082	broad.mit.edu	37	5	54275236	54275236	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:54275236T>A	ENST00000381405.4	-	3	624	c.479A>T	c.(478-480)aAt>aTt	p.N160I	ESM1_ENST00000381403.4_Missense_Mutation_p.N110I|ESM1_ENST00000598310.1_5'UTR	NM_007036.4	NP_008967.1	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1	160					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding			breast(1)|kidney(1)|large_intestine(4)|lung(4)	10		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			TCTCACAATATTGCCATCTCC	0.418000													25	35					0	0	1	0	0
SLC7A10	56301	broad.mit.edu	37	19	33702165	33702165	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:33702165C>T	ENST00000253188.3	-	7	1128	c.982G>A	c.(982-984)Gga>Aga	p.G328R		NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10	328					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					TTGATCCCTCCGAAGGTTGAC	0.587000													28	21					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128844825	128844825	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:128844825C>T	ENST00000274487.4	+	3	930	c.785C>T	c.(784-786)aCa>aTa	p.T262I	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	262					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CTCAATGATACAATGGCCATA	0.383000													7	55					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14939561	14939561	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:14939561C>T	ENST00000285046.5	+	6	3135	c.3025C>T	c.(3025-3027)Ctc>Ttc	p.L1009F	FGD5_ENST00000543601.1_Missense_Mutation_p.L768F|FGD5_ENST00000476851.1_3'UTR	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1009	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						TGAGAATTGCCTCCACTCTCC	0.597000													37	63					0	0	1	0	0
PLS1	5357	broad.mit.edu	37	3	142402951	142402951	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:142402951G>A	ENST00000337777.3	+	7	896	c.683G>A	c.(682-684)gGa>gAa	p.G228E	PLS1_ENST00000497002.1_Missense_Mutation_p.G228E|PLS1_ENST00000457734.2_Missense_Mutation_p.G228E	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	228	Actin-binding 1.|CH 1.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						TTGGTCTTGGGACTTCTCTGG	0.398000													37	69					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113529318	113529318	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:113529318G>A	ENST00000297405.5	-	28	4945	c.4701C>T	c.(4699-4701)acC>acT	p.T1567T	CSMD3_ENST00000343508.3_Silent_p.T1527T|CSMD3_ENST00000352409.3_Silent_p.T1567T|CSMD3_ENST00000455883.2_Silent_p.T1463T	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1567	Sushi 8.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCTGAATGCAGGTTATTCTTT	0.398000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			33	43					0	0	1	0	0
GPR63	0	broad.mit.edu	37	6	97246940	97246940	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:97246940G>A	ENST00000229955.3	-	2	1013	c.668C>T	c.(667-669)cCt>cTt	p.P223L	GPR63_ENST00000417980.1_Missense_Mutation_p.P223L	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	223						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AGCTCGGGAAGGTATCTGCAG	0.458000													15	61					0	0	1	0	0
SESN3	143686	broad.mit.edu	37	11	94918625	94918625	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:94918625G>T	ENST00000536441.1	-	5	893	c.557C>A	c.(556-558)tCt>tAt	p.S186Y	SESN3_ENST00000393234.1_Missense_Mutation_p.S186Y|SESN3_ENST00000278499.2_Missense_Mutation_p.S47Y|SESN3_ENST00000416495.2_Missense_Mutation_p.S186Y|RP11-712B9.2_ENST00000534891.1_RNA|RP11-712B9.2_ENST00000534864.1_RNA	NM_001271594.1|NM_144665.2	NP_001258523.1|NP_653266.2	P58005	SESN3_HUMAN	sestrin 3	186					cell cycle arrest	nucleus		p.S186Y(1)		endometrium(5)|large_intestine(6)|lung(3)|skin(1)|stomach(1)	16		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TTCAGGCAGAGACCAATTATT	0.363000													22	54					2.79863e-10	2.98826e-10	1	1	0
FBLN2	2199	broad.mit.edu	37	3	13612935	13612935	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:13612935G>A	ENST00000404922.3	+	2	1199	c.1080G>A	c.(1078-1080)ccG>ccA	p.P360P	FBLN2_ENST00000535798.1_Silent_p.P386P|FBLN2_ENST00000492059.1_Silent_p.P360P|FBLN2_ENST00000295760.7_Silent_p.P360P	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	360	N.|Subdomain NB (Cys-free).					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CGCATGCACCGAGCCTGGGCA	0.662000													4	10					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131476599	131476599	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131476599G>A	ENST00000291906.4	+	11	1829	c.1436G>A	c.(1435-1437)cGg>cAg	p.R479Q		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	479	Pro-rich.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						GGATGCCCTCGGACCCCAACA	0.652000													28	59					0	0	1	0	0
IKBKAP	8518	broad.mit.edu	37	9	111693365	111693365	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:111693365G>T	ENST00000374647.5	-	2	369	c.62C>A	c.(61-63)cCt>cAt	p.P21H	IKBKAP_ENST00000537196.1_Intron	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	21					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GAAGCACTGAGGATTCCCTGG	0.463000													6	76					0.00307968	0.00311927	1	1	0
TMEM183A	92703	broad.mit.edu	37	1	202984027	202984027	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:202984027C>T	ENST00000367242.3	+	4	458	c.378C>T	c.(376-378)gaC>gaT	p.D126D	TMEM183A_ENST00000468449.1_3'UTR	NM_001079809.1|NM_138391.4	NP_001073277.1|NP_612400.3			transmembrane protein 183A											endometrium(1)|large_intestine(2)|lung(1)|skin(3)	7			BRCA - Breast invasive adenocarcinoma(75;0.18)			AAGAACTGGACGGGGCTGGAG	0.398000													11	18					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17112906	17112906	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:17112906G>A	ENST00000265970.7	-	31	4852	c.4853C>T	c.(4852-4854)aCg>aTg	p.T1618M	PIK3C2A_ENST00000540361.1_Missense_Mutation_p.T1238M|PIK3C2A_ENST00000531428.1_5'UTR	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	1618	C2.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	CGGATTCCTCGTTTTTCGTGA	0.328000													28	52					0	0	1	0	0
PCDHB7	0	broad.mit.edu	37	5	140554290	140554290	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140554290G>A	ENST00000231137.3	+	1	2048	c.1874G>A	c.(1873-1875)cGt>cAt	p.R625H		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		625	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCGAGGTGCGTACCGCCAGG	0.697000													25	23					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36039662	36039662	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:36039662C>T	ENST00000282507.3	-	5	1093	c.992G>A	c.(991-993)tGt>tAt	p.C331Y	UGT3A2_ENST00000513300.1_Missense_Mutation_p.C297Y|UGT3A2_ENST00000545528.1_Missense_Mutation_p.C29Y	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	331						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGAACACTGACACTTCCATAT	0.517000													24	31					0	0	1	0	0
CAPN11	11131	broad.mit.edu	37	6	44137677	44137677	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:44137677G>A	ENST00000398776.1	+	4	412	c.374G>A	c.(373-375)gGg>gAg	p.G125E	CAPN11_ENST00000542245.1_Missense_Mutation_p.G125E	NM_007058.3	NP_008989.2	Q9UMQ6	CAN11_HUMAN	calpain 11	125	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	36	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ATCATGGATGGGATTTCTCCA	0.557000													3	14					0	0	1	0	0
FAM154B	283726	broad.mit.edu	37	15	82574587	82574587	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:82574587G>T	ENST00000339465.5	+	3	450	c.381G>T	c.(379-381)aaG>aaT	p.K127N	FAM154B_ENST00000565501.1_3'UTR|FAM154B_ENST00000427381.2_Missense_Mutation_p.K112N	NM_001008226.1	NP_001008227.1	Q658L1	F154B_HUMAN	family with sequence similarity 154, member B	127										autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)	19						AGGAGATAAAGCCTAGGCAAA	0.398000													56	88					2.73361e-28	3.05982e-28	1	1	0
PRKAR1B	5575	broad.mit.edu	37	7	618939	618939	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:618939A>G	ENST00000406797.1	-	9	1019	c.845T>C	c.(844-846)aTt>aCt	p.I282T	PRKAR1B_ENST00000537384.1_Missense_Mutation_p.I282T|PRKAR1B_ENST00000360274.4_Missense_Mutation_p.I282T|PRKAR1B_ENST00000403562.1_Missense_Mutation_p.I282T|PRKAR1B_ENST00000544935.1_Missense_Mutation_p.I282T	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	282					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		CTGGACCACAATTTTCTCTCC	0.612000													31	52					0	0	1	0	0
LLGL1	3996	broad.mit.edu	37	17	18141892	18141892	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18141892C>T	ENST00000316843.4	+	16	2271	c.2175C>T	c.(2173-2175)tgC>tgT	p.C725C		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	725					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					TCGTGCGTTGCCTATACTTTG	0.652000													4	41					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97916526	97916526	+	RNA	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:97916526A>G	ENST00000534948.1	+	0	1304							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AATTACCTTCATATCCTTGTG	0.368000													46	74					0	0	1	0	0
GDF7	151449	broad.mit.edu	37	2	20870397	20870397	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:20870397G>A	ENST00000272224.3	+	2	1141	c.565G>A	c.(565-567)Gcc>Acc	p.A189T		NM_182828.2	NP_878248.2	Q7Z4P5	GDF7_HUMAN	growth differentiation factor 7	189					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|cervix(1)|endometrium(2)|lung(1)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCGGGCGCCGCCCGAGCGCC	0.736000													5	8					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132446496	132446496	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:132446496C>T	ENST00000333577.4	+	2	1441	c.1332C>T	c.(1330-1332)gaC>gaT	p.D444D	EP400_ENST00000332482.4_Silent_p.D444D|EP400_ENST00000389561.2_Silent_p.D444D|EP400_ENST00000389562.2_Silent_p.D444D|EP400_ENST00000330386.6_Silent_p.D444D			Q96L91	EP400_HUMAN	E1A binding protein p400	444					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TTATCAATGACGAGGTAAGAA	0.378000													7	15					0	0	1	0	0
USP16	0	broad.mit.edu	37	21	30415788	30415788	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:30415788G>T	ENST00000334352.4	+	14	1455	c.1224G>T	c.(1222-1224)gtG>gtT	p.V408V	USP16_ENST00000535828.1_Silent_p.V37V|USP16_ENST00000399975.3_Silent_p.V407V|USP16_ENST00000399976.2_Silent_p.V408V	NM_001032410.1	NP_001027582.1	Q9Y5T5	UBP16_HUMAN	ubiquitin specific peptidase 16	408					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(2)	34						AAAAGACAGTGGAGGATGAAG	0.308000													15	10					0.000422831	0.000430994	1	1	0
PCYOX1	51449	broad.mit.edu	37	2	70502099	70502099	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:70502099G>A	ENST00000433351.2	+	4	531	c.503G>A	c.(502-504)cGc>cAc	p.R168H	PCYOX1_ENST00000264441.5_Missense_Mutation_p.R168H|PCYOX1_ENST00000505044.2_Missense_Mutation_p.R91H|PCYOX1_ENST00000545138.1_Missense_Mutation_p.R90H	NM_016297.3	NP_057381.3	Q9UHG3	PCYOX_HUMAN	prenylcysteine oxidase 1	168					prenylated protein catabolic process	lysosome|very-low-density lipoprotein particle	prenylcysteine oxidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)	15						AGGATCTACCGCTACCAGTCT	0.403000													26	34					0	0	1	0	0
LMNA	4000	broad.mit.edu	37	1	156100518	156100518	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156100518G>A	ENST00000368300.4	+	2	679	c.467G>A	c.(466-468)cGc>cAc	p.R156H	LMNA_ENST00000392353.3_Missense_Mutation_p.R75H|LMNA_ENST00000368297.1_Missense_Mutation_p.R75H|LMNA_ENST00000368299.3_Missense_Mutation_p.R156H|LMNA_ENST00000448611.2_Missense_Mutation_p.R44H|LMNA_ENST00000361308.4_Missense_Mutation_p.R156H|LMNA_ENST00000368301.2_Missense_Mutation_p.R156H|LMNA_ENST00000347559.2_Missense_Mutation_p.R156H|LMNA_ENST00000473598.2_Missense_Mutation_p.R57H	NM_170707.3	NP_733821.1	P02545	LMNA_HUMAN	lamin A/C	156	Coil 1B.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity			NS(1)|endometrium(1)|kidney(1)|lung(3)|ovary(4)	10	Hepatocellular(266;0.158)					AGTGAGAAGCGCACGCTGGAG	0.632000									Werner syndrome;Hutchinson-Gilford Progeria Syndrome		OREG0013866	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	8					0	0	1	0	0
ASNA1	439	broad.mit.edu	37	19	12856477	12856477	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12856477C>T	ENST00000591090.1	+	5	615	c.513C>T	c.(511-513)ggC>ggT	p.G171G	ASNA1_ENST00000357332.3_Silent_p.G171G			O43681	ASNA_HUMAN	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	171					response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding			endometrium(1)|lung(6)|ovary(3)	10					Adenosine triphosphate(DB00171)	CACCCACGGGCCACACCCTGA	0.612000													20	11					0	0	1	0	0
AMMECR1L	83607	broad.mit.edu	37	2	128631466	128631466	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:128631466C>T	ENST00000272647.5	-	3	603	c.343G>A	c.(343-345)Gta>Ata	p.V115I	AMMECR1L_ENST00000393001.1_Missense_Mutation_p.V115I	NM_001199140.1	NP_001186069.1	Q6DCA0	AMERL_HUMAN	AMMECR1-like	115	AMMECR1.									central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	9	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.07)		CAGTAGAGTACGTCGAAGCAG	0.552000													37	56					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45404113	45404113	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:45404113G>A	ENST00000389039.6	-	5	751	c.366C>T	c.(364-366)ccC>ccT	p.P122P	DUOX2_ENST00000603300.1_Silent_p.P122P			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	122	Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CGGGGCAACCGGGCGTTTCCA	0.662000													6	11					0	0	1	0	0
RBM28	55131	broad.mit.edu	37	7	127979741	127979741	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:127979741C>T	ENST00000223073.1	-	2	337	c.223G>A	c.(223-225)Gtg>Atg	p.V75M	RBM28_ENST00000415472.2_Intron	NM_018077.2	NP_060547.2	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	75	RRM 1.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			breast(1)|kidney(7)|large_intestine(3)|lung(8)|ovary(2)	21						GCAACAGTCACGTTGATCTTG	0.438000													30	60					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60643128	60643128	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:60643128G>A	ENST00000278853.5	+	12	1916	c.1916G>A	c.(1915-1917)tGa>tAa	p.*639*		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	0					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						AACAGACAGTGAATGGGCCCA	0.478000													6	11					0	0	1	0	0
CDKL1	8814	broad.mit.edu	37	14	50796808	50796808	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:50796808C>T	ENST00000395834.1	-	9	1088	c.1061G>A	c.(1060-1062)cGt>cAt	p.R354H	ATP5S_ENST00000358473.1_Intron	NM_004196.3	NP_004187.2	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1 (CDC2-related kinase)	353						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|stomach(1)	12	all_epithelial(31;0.000746)|Breast(41;0.0102)					GTTTGGAAAACGGTAGTTAAG	0.343000													17	45					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88248234	88248234	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:88248234C>T	ENST00000357081.3	-	14	1502	c.1358G>A	c.(1357-1359)cGt>cAt	p.R453H	AGTPBP1_ENST00000376109.3_Missense_Mutation_p.R465H|AGTPBP1_ENST00000376083.3_Missense_Mutation_p.R413H|AGTPBP1_ENST00000337006.4_3'UTR|AGTPBP1_ENST00000432218.1_Missense_Mutation_p.R291H			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	453					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						AATAGGACCACGTACTTTTCC	0.333000													32	52					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	527766	527766	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:527766C>T	ENST00000453061.2	+	12	2837	c.2731C>T	c.(2731-2733)Cgc>Tgc	p.R911C	PIGG_ENST00000310340.5_Missense_Mutation_p.R903C|PIGG_ENST00000504346.1_Missense_Mutation_p.R822C|PIGG_ENST00000383028.4_Missense_Mutation_p.R778C|PIGG_ENST00000296306.7_3'UTR	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	911					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CTCAGAAACACGCAGGTGAGG	0.597000													12	20					0	0	1	0	0
PCYT1A	5130	broad.mit.edu	37	3	195968904	195968904	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195968904C>T	ENST00000292823.2	-	8	795	c.623G>A	c.(622-624)cGa>cAa	p.R208Q	PCYT1A_ENST00000419333.1_Missense_Mutation_p.R208Q|PCYT1A_ENST00000431016.1_Missense_Mutation_p.R208Q	NM_005017.2	NP_005008.2	P49585	PCY1A_HUMAN	phosphate cytidylyltransferase 1, choline, alpha	208	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity			cervix(1)|endometrium(3)|large_intestine(8)|lung(5)|ovary(1)	18	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	CCGCACAATTCGGGTGATGAT	0.483000													36	48					0	0	1	0	0
DAGLB	221955	broad.mit.edu	37	7	6474468	6474468	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:6474468G>A	ENST00000297056.6	-	4	772	c.603C>T	c.(601-603)tgC>tgT	p.C201C	DAGLB_ENST00000425398.2_Intron|DAGLB_ENST00000421761.2_Intron|DAGLB_ENST00000428902.2_Silent_p.C74C|DAGLB_ENST00000436575.1_Silent_p.C160C	NM_139179.3	NP_631918.3	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta	201					lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|urinary_tract(2)	26		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		CAATGCAACAGCACAAGAGCT	0.502000													13	131					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175763860	175763860	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:175763860C>T	ENST00000443967.1	+	10	2659	c.2252C>T	c.(2251-2253)aCg>aTg	p.T751M	SIMC1_ENST00000430704.2_Missense_Mutation_p.T336M|SIMC1_ENST00000341199.6_Missense_Mutation_p.T336M|SIMC1_ENST00000332772.4_Missense_Mutation_p.T212M					SUMO-interacting motifs containing 1																		AATAATTCTACGTCACTGCTC	0.502000													15	26					0	0	1	0	0
MROH6	642475	broad.mit.edu	37	8	144654782	144654782	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:144654782G>A	ENST00000398882.3	-	1	359	c.103C>T	c.(103-105)Ccc>Tcc	p.P35S		NM_001100878.1	NP_001094348.1			maestro heat-like repeat family member 6																		GGTCCCTGGGGCTGCCCCTGC	0.706000													4	6					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121000865	121000865	+	Silent	SNP	C	C	T	rs138065050		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:121000865C>T	ENST00000392793.1	+	10	3157	c.2886C>T	c.(2884-2886)agC>agT	p.S962S	TECTA_ENST00000264037.2_Silent_p.S962S			O75443	TECTA_HUMAN	tectorin alpha	962					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGTATGCAAGCGCCTGCAAGA	0.582000													16	31					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38354889	38354889	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38354889C>T	ENST00000273173.4	+	6	1167	c.1076C>T	c.(1075-1077)cCc>cTc	p.P359L	SLC22A14_ENST00000448498.1_Missense_Mutation_p.P359L	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	359						integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		CTGCAGCTGCCCAGAAAGAAG	0.592000													31	51					0	0	1	0	0
RAD9A	5883	broad.mit.edu	37	11	67163738	67163738	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67163738G>A	ENST00000307980.2	+	9	832	c.739G>A	c.(739-741)Gcc>Acc	p.A247T	RAD9A_ENST00000535644.1_3'UTR	NM_001243224.1|NM_004584.2	NP_001230153.1|NP_004575.1	Q99638	RAD9A_HUMAN	RAD9 homolog A (S. pombe)	247					DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding			lung(7)|upper_aerodigestive_tract(1)	8			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			GCCCAGGCCCGCCATCTTCAC	0.632000								Other conserved DNA damage response genes					35	53					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55955037	55955037	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:55955037G>A	ENST00000263923.4	-	26	3803	c.3508C>T	c.(3508-3510)Cag>Tag	p.Q1170*	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1170					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TGACAAACCTGCTGAGCATTA	0.507000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			6	20					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109876340	109876340	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:109876340G>A	ENST00000310903.5	+	23	2267		c.e23-1		MYO1H_ENST00000431443.2_Splice_Site			B4DNW6	B4DNW6_HUMAN	myosin IH							myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						AACTCTTTCAGCCATCAAACT	0.498000													3	8					0	0	1	0	0
RXRA	6256	broad.mit.edu	37	9	137313559	137313559	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:137313559A>G	ENST00000540193.1	+	5	1450	c.527A>G	c.(526-528)gAc>gGc	p.D176G	RXRA_ENST00000356384.4_3'UTR|RXRA_ENST00000481739.1_Missense_Mutation_p.D273G			P19793	RXRA_HUMAN	retinoid X receptor, alpha	273					cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CAAGCAGCCGACAAACAGCTT	0.582000													26	75					0	0	1	0	0
ULK2	9706	broad.mit.edu	37	17	19705103	19705103	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:19705103T>C	ENST00000395544.4	-	16	1927	c.1428A>G	c.(1426-1428)tcA>tcG	p.S476S	ULK2_ENST00000580130.1_5'UTR|ULK2_ENST00000361658.2_Silent_p.S476S	NM_014683.3	NP_055498.3	Q8IYT8	ULK2_HUMAN	unc-51 like autophagy activating kinase 2	476					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					AAGGGGAAGGTGAGTAAGGCC	0.473000													34	52					0	0	1	0	0
USP35	57558	broad.mit.edu	37	11	77918623	77918623	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:77918623T>G	ENST00000529308.1	+	8	1700	c.1439T>G	c.(1438-1440)cTg>cGg	p.L480R	USP35_ENST00000526425.1_Missense_Mutation_p.L211R|USP35_ENST00000530267.1_Missense_Mutation_p.L48R|USP35_ENST00000441408.2_Missense_Mutation_p.L66R|USP35_ENST00000530535.1_Intron	NM_020798.2	NP_065849.1	Q9P2H5	UBP35_HUMAN	ubiquitin specific peptidase 35	480					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(3)|urinary_tract(1)	23	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			TCACAGCCCCTGATGACCAAG	0.587000													53	63					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	82997121	82997121	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:82997121C>T	ENST00000307792.3	-	17	2576	c.2109G>A	c.(2107-2109)tcG>tcA	p.S703S	SEMA3E_ENST00000427262.1_Silent_p.S643S	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	703					axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				TTGCTCCCTGCGAGATGCTAC	0.478000													41	65					0	0	1	0	0
ZNF793	390927	broad.mit.edu	37	19	38028574	38028574	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38028574G>A	ENST00000445217.1	+	4	1049	c.1014G>A	c.(1012-1014)ccG>ccA	p.P338P	ZNF793_ENST00000587143.1_Silent_p.P338P|ZNF793_ENST00000589319.1_Intron|ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000542455.1_Silent_p.P338P			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAGAAAGACCGTATCGTTGCA	0.453000													14	20					0	0	1	0	0
B3GNT1	11041	broad.mit.edu	37	11	66114449	66114449	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66114449C>T	ENST00000311181.4	-	1	714	c.568G>A	c.(568-570)Gcc>Acc	p.A190T		NM_006876.2	NP_006867.1	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1	190					poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(1)	12						GCCACCCTGGCTAGCTTGTCA	0.642000													8	30					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627507	43627507	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:43627507C>T	ENST00000332857.6	-	4	1208	c.1180G>A	c.(1180-1182)Gga>Aga	p.G394R		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		TTCTGAGGTCCGGGCAGCTGT	0.498000													96	119					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38564352	38564352	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38564352G>A	ENST00000423485.1	-	12	1525	c.1367C>T	c.(1366-1368)aCg>aTg	p.T456M		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	456					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	CAGGATAAGCGTACACTCAGT	0.393000													23	16					0	0	1	0	0
CRAT	1384	broad.mit.edu	37	9	131864769	131864769	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131864769G>A	ENST00000318080.2	-	5	834	c.540C>T	c.(538-540)tgC>tgT	p.C180C	CRAT_ENST00000464290.1_5'UTR	NM_000755.3|NM_001257363.1	NP_000746.2|NP_001244292.1	P43155	CACP_HUMAN	carnitine O-acetyltransferase	180					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	CCGGCACTCGGCAGGAGGACA	0.607000													8	194					0	0	1	0	0
EIF5A	1984	broad.mit.edu	37	17	7214356	7214356	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7214356A>T	ENST00000336458.8	+	3	586	c.185A>T	c.(184-186)gAc>gTc	p.D62V	EIF5A_ENST00000576930.1_Missense_Mutation_p.D62V|EIF5A_ENST00000571955.1_Missense_Mutation_p.D62V|EIF5A_ENST00000419711.2_Missense_Mutation_p.D62V|EIF5A_ENST00000416016.2_Missense_Mutation_p.D62V|EIF5A_ENST00000336452.7_Missense_Mutation_p.D92V|EIF5A_ENST00000573542.1_Missense_Mutation_p.D62V|EIF5A_ENST00000572815.1_Missense_Mutation_p.D62V	NM_001970.4	NP_001961.1	P63241	IF5A1_HUMAN	eukaryotic translation initiation factor 5A	62	DOHH-binding.				induction of apoptosis|mRNA export from nucleus|peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein export from nucleus|translational frameshifting|transmembrane transport	annulate lamellae|cytosol|endoplasmic reticulum membrane|nuclear pore	protein N-terminus binding|ribosome binding|translation elongation factor activity|U6 snRNA binding			endometrium(2)|kidney(1)|large_intestine(2)|urinary_tract(1)	6						GTTGGTATTGACATCTTTACT	0.408000													44	60					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23894603	23894603	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23894603C>A	ENST00000355349.3	-	21	2473	c.2311G>T	c.(2311-2313)Ggg>Tgg	p.G771W		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	771	Actin-binding.|Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCAGCAGCCCCAGCAGCCCG	0.582000													8	24					1.76689e-08	1.86465e-08	1	1	0
STXBP6	0	broad.mit.edu	37	14	25288249	25288249	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:25288249C>T	ENST00000323944.5	-	5	1054	c.603G>A	c.(601-603)gcG>gcA	p.A201A	STXBP6_ENST00000550887.1_Silent_p.A201A|STXBP6_ENST00000358326.2_Silent_p.A201A|STXBP6_ENST00000419632.2_Silent_p.A201A|STXBP6_ENST00000546511.1_Silent_p.A201A|STXBP6_ENST00000548369.1_Silent_p.A99A|STXBP6_ENST00000548724.1_Silent_p.A201A|STXBP6_ENST00000396700.1_Silent_p.A201A			Q8NFX7	STXB6_HUMAN	syntaxin binding protein 6 (amisyn)	201	v-SNARE coiled-coil homology.				vesicle-mediated transport	cytoplasm|integral to membrane				central_nervous_system(2)|endometrium(2)|large_intestine(3)	7				GBM - Glioblastoma multiforme(265;0.0296)		CCACCTTGTGCGCAGTTTCTG	0.532000													23	45					0	0	1	0	0
SGK1	6446	broad.mit.edu	37	6	134492174	134492174	+	Missense_Mutation	SNP	G	G	A	rs55932330		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:134492174G>A	ENST00000367858.5	-	12	1907	c.1310C>T	c.(1309-1311)gCc>gTc	p.A437V	SGK1_ENST00000475719.2_Missense_Mutation_p.A298V|SGK1_ENST00000413996.3_Missense_Mutation_p.A356V|SGK1_ENST00000528577.1_Missense_Mutation_p.A370V|SGK1_ENST00000367857.5_Missense_Mutation_p.A332V|SGK1_ENST00000237305.7_Missense_Mutation_p.A342V	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	342					apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		GTCATCCTTGGCCCCGAGCCG	0.527000													20	22					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2048706	2048706	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:2048706G>A	ENST00000262113.4	+	20	2622	c.2481G>A	c.(2479-2481)acG>acA	p.T827T	MYOM2_ENST00000523438.1_Silent_p.T252T	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	827	Fibronectin type-III 5.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TCAGGGACACGTCCTTGGTCA	0.582000													11	17					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150723083	150723083	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:150723083C>T	ENST00000335244.4	-	3	461	c.332G>A	c.(331-333)cGc>cAc	p.R111H	SLC36A2_ENST00000521967.1_Missense_Mutation_p.R111H	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	111					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTTACAGAAGCGCTGGGCACA	0.517000													13	30					0	0	1	0	0
GLE1	2733	broad.mit.edu	37	9	131267153	131267153	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131267153C>T	ENST00000309971.4	+	1	175	c.69C>T	c.(67-69)tgC>tgT	p.C23C	GLE1_ENST00000372770.4_Silent_p.C23C|GLE1_ENST00000539582.1_5'UTR	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator	23	Interaction with NUP155.				poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						GTCGCCTTTGCTACTACCGCG	0.657000													20	33					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86512508	86512508	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:86512508C>A	ENST00000370571.2	-	12	2316	c.1950_splice	c.e12+1	p.Q650_splice	COL24A1_ENST00000436319.1_Splice_Site_p.Q650_splice	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	650					cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		ATTAAGATACCTGTCTCCCCT	0.313000													9	65					9.70103e-10	1.03282e-09	1	1	0
OPN1SW	611	broad.mit.edu	37	7	128412651	128412651	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128412651G>C	ENST00000249389.2	-	5	989	c.990C>G	c.(988-990)tgC>tgG	p.C330W		NM_001708.2	NP_001699.1	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	330					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|stomach(1)	19						TCTGGGAGCTGCATGTGTCGG	0.458000													5	50					0	0	1	0	0
IL23R	149233	broad.mit.edu	37	1	67633805	67633805	+	Translation_Start_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:67633805T>C	ENST00000347310.5	+	2	173	c.2T>C	c.(1-3)aTg>aCg	p.M1T	C1orf141_ENST00000371007.2_Intron|IL23R_ENST00000371002.1_Start_Codon_SNP_p.M1T	NM_144701.2	NP_653302.2	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor	1					inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						CTTCCAGACATGAATCAGGTC	0.318000													4	80					0	0	1	0	0
PDZD9	255762	broad.mit.edu	37	16	21995749	21995749	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:21995749C>T	ENST00000286143.6	-	5	769	c.448G>A	c.(448-450)Gac>Aac	p.D150N	PDZD9_ENST00000424898.2_Missense_Mutation_p.D212N|PDZD9_ENST00000537222.2_Missense_Mutation_p.D152N			Q8IXQ8	PDZD9_HUMAN	PDZ domain containing 9	212										breast(3)|endometrium(2)|lung(3)|pancreas(1)	9						TCTTTCTTGTCGTCTCTGTGA	0.423000													49	67					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9476069	9476069	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9476069C>T	ENST00000402198.1	+	5	664	c.229C>T	c.(229-231)Cgc>Tgc	p.R77C	SETD5_ENST00000406341.1_Missense_Mutation_p.R77C|SETD5_ENST00000302463.6_5'UTR|SETD5_ENST00000407969.1_Missense_Mutation_p.R96C|SETD5_ENST00000402466.1_5'UTR	NM_001080517.1	NP_001073986.1	Q9C0A6	SETD5_HUMAN	SET domain containing 5	77			R -> H (in dbSNP:rs41387348).							NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		TGTAGAGGAACGCTGTGGAGA	0.567000													10	24					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15669723	15669723	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:15669723C>A	ENST00000281171.4	+	9	1942	c.1612C>A	c.(1612-1614)Ctc>Atc	p.L538I	PTPRO_ENST00000348962.2_Missense_Mutation_p.L538I|PTPRO_ENST00000543886.1_Missense_Mutation_p.L538I	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	538	Fibronectin type-III 6.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				GGATTTAATGCTCTATCCTTT	0.433000													35	43					6.90743e-12	7.45315e-12	1	1	0
SHBG	6462	broad.mit.edu	37	17	7535020	7535020	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7535020C>A	ENST00000380450.4	+	5	700	c.669C>A	c.(667-669)ccC>ccA	p.P223P	SHBG_ENST00000340624.5_Silent_p.P165P|SHBG_ENST00000575314.1_Silent_p.P165P|SHBG_ENST00000416273.3_Silent_p.P223P|SHBG_ENST00000570547.1_Silent_p.P165P|SHBG_ENST00000576478.1_Silent_p.P111P|SHBG_ENST00000572182.1_Intron|SHBG_ENST00000574539.1_Silent_p.P165P|SHBG_ENST00000572262.1_Silent_p.P111P|SHBG_ENST00000441599.2_Silent_p.P223P|SHBG_ENST00000575903.1_Silent_p.P205P|SHBG_ENST00000576728.1_Silent_p.P111P	NM_001040.3	NP_001031.2	P04278	SHBG_HUMAN	sex hormone-binding globulin	223					hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.0?(1)|p.?(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	AATCAAATCCCGGGATATTTC	0.557000													84	124					3.1376e-36	3.52241e-36	1	1	0
RELA	5970	broad.mit.edu	37	11	65426220	65426220	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65426220C>A	ENST00000525693.1	-	7	695	c.633G>T	c.(631-633)gaG>gaT	p.E211D	RELA_ENST00000406246.3_Missense_Mutation_p.E211D|RELA_ENST00000308639.9_Missense_Mutation_p.E208D			Q04206	TF65_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog A	211	RHD.				anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(11)|ovary(1)|urinary_tract(1)	19						GTAGGAAGATCTCATCCCCAC	0.567000													7	73					0.0477658	0.0480142	1	1	0
HSP90B1	7184	broad.mit.edu	37	12	104336443	104336443	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104336443C>T	ENST00000299767.5	+	12	1695	c.1513C>T	c.(1513-1515)Cgt>Tgt	p.R505C		NM_003299.1	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	505					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	GAATCGAACACGTCTTGCTAA	0.373000													12	65					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74825075	74825075	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:74825075G>A	ENST00000256362.4	+	2	1830	c.1589G>A	c.(1588-1590)cGc>cAc	p.R530H		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	530					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						TGCCGCTTCCGCCTCCGCTAC	0.652000													62	84					0	0	1	0	0
POC5	134359	broad.mit.edu	37	5	74981187	74981187	+	Missense_Mutation	SNP	G	G	A	rs138072982	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:74981187G>A	ENST00000428202.2	-	10	1441	c.1252C>T	c.(1252-1254)Cca>Tca	p.P418S	POC5_ENST00000380475.2_Missense_Mutation_p.P301S|POC5_ENST00000514838.2_Missense_Mutation_p.P390S|POC5_ENST00000510798.1_Missense_Mutation_p.P301S|POC5_ENST00000446329.2_Missense_Mutation_p.P393S	NM_001099271.1	NP_001092741.1	Q8NA72	POC5_HUMAN	POC5 centriolar protein	418					cell cycle	centriole				breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						GGTGGGGATGGCAGCAGTGGT	0.552000													19	36					0	0	1	0	0
YTHDC2	64848	broad.mit.edu	37	5	112915367	112915367	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:112915367G>T	ENST00000161863.4	+	24	3542	c.3329G>T	c.(3328-3330)tGg>tTg	p.W1110L		NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1110							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		CTTGATGAGTGGCTCCATTTC	0.363000													22	45					8.04996e-18	8.87193e-18	1	1	0
ABHD2	11057	broad.mit.edu	37	15	89734361	89734361	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:89734361G>A	ENST00000352732.5	+	9	1497	c.977G>A	c.(976-978)tGc>tAc	p.C326Y	ABHD2_ENST00000565973.1_Missense_Mutation_p.C326Y|ABHD2_ENST00000355100.3_Missense_Mutation_p.C326Y	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	326						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					GAAGAAAGTTGCATGCGGTAC	0.463000													41	58					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150842563	150842563	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:150842563C>T	ENST00000370357.4	+	15	2325	c.2080C>T	c.(2080-2082)Caa>Taa	p.Q694*		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	694						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CCGGCTTTGGCAAGAGTTGTC	0.517000													30	9					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46807241	46807241	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46807241C>A	ENST00000377670.4	+	2	144	c.113C>A	c.(112-114)gCt>gAt	p.A38D	HIF3A_ENST00000420102.2_Missense_Mutation_p.L36I|HIF3A_ENST00000600383.1_Missense_Mutation_p.L18I|HIF3A_ENST00000472815.1_Missense_Mutation_p.L18I|HIF3A_ENST00000244303.6_Missense_Mutation_p.L18I|HIF3A_ENST00000300862.3_Missense_Mutation_p.A36D|HIF3A_ENST00000339613.2_5'UTR	NM_152795.3	NP_690008.2	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	38	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		TACCAGCTGGCTCACACGCTG	0.692000													3	3					0.00024832	0.000253518	1	1	0
DPP8	54878	broad.mit.edu	37	15	65759487	65759487	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:65759487G>A	ENST00000341861.5	-	13	3239	c.1659C>T	c.(1657-1659)taC>taT	p.Y553Y	DPP8_ENST00000559233.1_Silent_p.Y553Y|DPP8_ENST00000339244.5_Silent_p.Y380Y|DPP8_ENST00000358939.4_Silent_p.Y537Y|DPP8_ENST00000321147.6_Silent_p.Y553Y|DPP8_ENST00000321118.7_Silent_p.Y553Y|DPP8_ENST00000300141.6_Silent_p.Y537Y	NM_197960.2	NP_932064.1	Q6V1X1	DPP8_HUMAN	dipeptidyl-peptidase 8	553					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(11)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						AACTGACTACGTACAGGTGAT	0.418000													8	57					0	0	1	0	0
HDX	139324	broad.mit.edu	37	X	83724079	83724079	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:83724079G>A	ENST00000297977.5	-	3	763	c.652C>T	c.(652-654)Cga>Tga	p.R218*	HDX_ENST00000506585.2_Nonsense_Mutation_p.R160*|HDX_ENST00000373177.2_Nonsense_Mutation_p.R218*	NM_001177479.1|NM_144657.4	NP_001170950.1|NP_653258.2	Q7Z353	HDX_HUMAN	highly divergent homeobox	218						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						TTACAAGGTCGGTGGCACACA	0.413000													61	17					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111080821	111080821	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:111080821C>T	ENST00000360467.5	+	7	674	c.368C>T	c.(367-369)cCg>cTg	p.P123L		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	123					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CAGGGACACCCGGGGCAAGGT	0.582000													13	34					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	124008246	124008246	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:124008246C>T	ENST00000369005.1	+	20	8821	c.8481C>T	c.(8479-8481)tcC>tcT	p.S2827S	TACC2_ENST00000515603.1_Silent_p.S2705S|TACC2_ENST00000334433.3_Silent_p.S2827S|TACC2_ENST00000369004.3_Silent_p.S887S|TACC2_ENST00000260733.3_Silent_p.S905S|TACC2_ENST00000368999.1_Silent_p.S917S|TACC2_ENST00000453444.2_Silent_p.S2754S|TACC2_ENST00000515273.1_Silent_p.S2754S|TACC2_ENST00000360561.3_Silent_p.S875S|TACC2_ENST00000369000.1_Silent_p.S450S|TACC2_ENST00000369001.1_Silent_p.S454S|TACC2_ENST00000358010.1_Silent_p.S973S|TACC2_ENST00000513429.1_Silent_p.S973S	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2827						microtubule organizing center|nucleus	nuclear hormone receptor binding	p.S2827S(1)		NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ACCTGAACTCCGTGGAGAAGT	0.582000													26	52					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28358764	28358764	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:28358764G>A	ENST00000337532.5	-	14	1417	c.1141C>T	c.(1141-1143)Ctg>Ttg	p.L381L	MPP7_ENST00000540098.1_Silent_p.L381L|MPP7_ENST00000375719.3_Silent_p.L381L|MPP7_ENST00000375732.1_Silent_p.L381L|MPP7_ENST00000445954.2_Silent_p.L256L	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	381	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						AGTTCATTCAGCCCTACTCCC	0.463000													10	28					0	0	1	0	0
WDR36	134430	broad.mit.edu	37	5	110434431	110434431	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:110434431C>A	ENST00000506538.2	+	4	1044	c.471C>A	c.(469-471)acC>acA	p.T157T	WDR36_ENST00000505303.1_Silent_p.T101T|WDR36_ENST00000513710.2_Silent_p.T157T	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	157					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		TAGTACATACCTTTAAGGGTC	0.318000													14	33					0.000151284	0.000155038	1	1	0
ZNF737	100129842	broad.mit.edu	37	19	20728103	20728103	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:20728103C>T	ENST00000427401.4	-	4	1000	c.906G>A	c.(904-906)gcG>gcA	p.A302A		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	302					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						TTATCTTATGCGCAGTAAGGA	0.403000													17	34					0	0	1	0	0
KIAA1644	85352	broad.mit.edu	37	22	44681532	44681532	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:44681532G>A	ENST00000381176.4	-	4	507	c.375C>T	c.(373-375)taC>taT	p.Y125Y		NM_001099294.1	NP_001092764.1	Q3SXP7	K1644_HUMAN	KIAA1644	125						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				TGCAGATGTCGTAGTTCATTG	0.572000													28	133					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72345307	72345307	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:72345307G>A	ENST00000299687.5	+	1	2332	c.2332G>A	c.(2332-2334)Gta>Ata	p.V778I	ZNF407_ENST00000577538.1_Missense_Mutation_p.V778I|ZNF407_ENST00000309902.6_Missense_Mutation_p.V778I|ZNF407_ENST00000582337.1_Missense_Mutation_p.V778I	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	778					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TATTGAAAGGGTATGTATAGG	0.343000													26	41					0	0	1	0	0
BAHD1	22893	broad.mit.edu	37	15	40756193	40756193	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40756193C>A	ENST00000561234.1	+	4	2205	c.1946C>A	c.(1945-1947)tCt>tAt	p.S649Y	BAHD1_ENST00000416165.1_Missense_Mutation_p.S650Y|BAHD1_ENST00000560846.1_Missense_Mutation_p.S650Y			Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	650	BAH.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(3)|lung(10)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	28		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		GCCAAGATCTCTGCCCTCTGG	0.612000													18	16					1.45105e-14	1.58388e-14	1	1	0
KIAA1324	57535	broad.mit.edu	37	1	109716141	109716141	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109716141G>A	ENST00000369939.3	+	6	925	c.742G>A	c.(742-744)Gcc>Acc	p.A248T	KIAA1324_ENST00000529753.1_Missense_Mutation_p.A248T	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	248					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GAGAACCACAGCCTTCTCAGT	0.453000													37	64					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49050727	49050727	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49050727G>A	ENST00000395474.3	+	2	2130	c.1850G>A	c.(1849-1851)cGt>cAt	p.R617H	WDR6_ENST00000489684.1_3'UTR|WDR6_ENST00000448293.1_Missense_Mutation_p.R536H|WDR6_ENST00000415265.2_Missense_Mutation_p.R35H	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	587					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		ACCACAGGGCGTGATGGAGCC	0.587000													11	13					0	0	1	0	0
LMX1B	4010	broad.mit.edu	37	9	129458221	129458221	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:129458221C>T	ENST00000355497.5	+	7	1030	c.1023C>T	c.(1021-1023)agC>agT	p.S341S	LMX1B_ENST00000425646.2_Silent_p.S307S|LMX1B_ENST00000526117.1_Silent_p.S330S|LMX1B_ENST00000373474.4_Silent_p.S330S|LMX1B_ENST00000561065.1_Silent_p.S318S	NM_001174146.1	NP_001167617.1	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	307					dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	15						ACGGCAGCAGCGACCCCTTCC	0.672000									Nail-Patella Syndrome				3	13					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44109032	44109032	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:44109032G>A	ENST00000262419.6	-	15	3598	c.3128C>T	c.(3127-3129)gCg>gTg	p.A1043V	KANSL1_ENST00000574590.1_Missense_Mutation_p.A1043V|KANSL1_ENST00000575318.1_Missense_Mutation_p.A979V|KANSL1_ENST00000393476.3_Missense_Mutation_p.A337V|KANSL1_ENST00000432791.1_Missense_Mutation_p.A1043V|KANSL1_ENST00000572904.1_Missense_Mutation_p.A1043V	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	1043						MLL1 complex	protein binding										GGGACTGTGCGCCAGGGGGAA	0.657000													6	16					0	0	1	0	0
SGTA	6449	broad.mit.edu	37	19	2768990	2768990	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2768990G>A	ENST00000221566.2	-	2	238	c.77C>T	c.(76-78)tCc>tTc	p.S26F		NM_003021.3	NP_003012.1	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	26					interspecies interaction between organisms	cytoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGAGCATCGGACGAGAGGCC	0.627000													15	38					0	0	1	0	0
PCDHGA5	0	broad.mit.edu	37	5	140743899	140743899	+	Translation_Start_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140743899T>C	ENST00000518069.1	+	1	2	c.2T>C	c.(1-3)aTg>aCg	p.M1T	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAAGGCAATGGCGAGTCCA	0.562000													13	11					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43119098	43119098	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43119098C>T	ENST00000428554.2	+	22	3268	c.2125C>T	c.(2125-2127)Cct>Tct	p.P709S	CCDC30_ENST00000342022.4_Missense_Mutation_p.P709S|CCDC30_ENST00000390640.4_Missense_Mutation_p.P498S|CCDC30_ENST00000507855.1_Missense_Mutation_p.P498S|CCDC30_ENST00000340612.4_Missense_Mutation_p.P709S			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	709										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						TGAAATATTGCCTTTATCAAA	0.363000													27	45					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60895811	60895811	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:60895811G>A	ENST00000252999.3	-	49	6698	c.6632C>T	c.(6631-6633)tCc>tTc	p.S2211F		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2211	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCAGCGATGGAGGCGTTCAG	0.677000													4	13					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243354606	243354606	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:243354606A>G	ENST00000366542.1	-	8	873	c.822T>C	c.(820-822)ggT>ggC	p.G274G	CEP170_ENST00000366544.1_Silent_p.G274G|CEP170_ENST00000366543.1_Silent_p.G274G	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	274						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CATGCCCTGCACCTGTTATAT	0.408000													7	14					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158725149	158725149	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158725149C>A	ENST00000368144.2	+	1	640	c.544C>A	c.(544-546)Ctc>Atc	p.L182I		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					TTGTGGCTTCCTCCTTGTGCT	0.473000													20	42					2.37509e-13	2.57931e-13	1	1	0
USH2A	7399	broad.mit.edu	37	1	215802302	215802302	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:215802302G>A	ENST00000366943.2	-	72	15831	c.15445C>T	c.(15445-15447)Cgc>Tgc	p.R5149C	USH2A_ENST00000307340.3_Missense_Mutation_p.R5125C			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	5125					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTCGGGATGCGCAGGACACAT	0.527000										HNSCC(13;0.011)			27	40					0	0	1	0	0
HECTD3	79654	broad.mit.edu	37	1	45469960	45469960	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:45469960A>G	ENST00000372172.4	-	17	2303	c.2232T>C	c.(2230-2232)tgT>tgC	p.C744C	HECTD3_ENST00000372168.3_Silent_p.C354C|HECTD3_ENST00000486132.1_5'UTR	NM_024602.5	NP_078878.3	Q5T447	HECD3_HUMAN	HECT domain containing E3 ubiquitin protein ligase 3	744	HECT.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|stomach(1)	28	Acute lymphoblastic leukemia(166;0.155)					CTGGATCCCCACACACTTTCT	0.612000													24	39					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93800805	93800805	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:93800805C>T	ENST00000315765.9	+	5	960	c.952C>T	c.(952-954)Cat>Tat	p.H318Y		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	318	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CAGCAGAGGGCATCGGACTGA	0.473000													45	97					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18254660	18254660	+	Silent	SNP	C	C	T	rs4808753		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18254660C>T	ENST00000262811.5	+	21	2340	c.2340C>T	c.(2338-2340)acC>acT	p.T780T		NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3	780							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						TCCTGAATACCATCAGCCTGG	0.607000													12	17					0	0	1	0	0
DNAJC19	131118	broad.mit.edu	37	3	180704808	180704808	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:180704808G>T	ENST00000382564.2	-	4	302	c.132C>A	c.(130-132)gcC>gcA	p.A44A	DNAJC19_ENST00000491873.1_Silent_p.A19A|DNAJC19_ENST00000479269.1_Silent_p.A19A|DNAJC19_ENST00000486355.1_Silent_p.A44A	NM_145261.3	NP_660304.1	Q96DA6	TIM14_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 19	44					genitalia development|protein folding|protein targeting to mitochondrion|transmembrane transport|visual perception	integral to membrane|mitochondrial inner membrane	heat shock protein binding			large_intestine(2)|lung(1)	3	all_cancers(143;3.12e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-36)|OV - Ovarian serous cystadenocarcinoma(80;1.55e-22)			CACCACTGAAGGCCTGAAAGA	0.323000													41	78					4.06502e-11	4.36823e-11	1	1	0
FAM184A	79632	broad.mit.edu	37	6	119295631	119295631	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:119295631G>A	ENST00000338891.7	-	14	3320	c.2877C>T	c.(2875-2877)aaC>aaT	p.N959N	FAM184A_ENST00000521531.1_Intron|RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000352896.5_Intron|FAM184A_ENST00000368475.4_Intron	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	959										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						TGAGTAGCTCGTTAGTCTTAT	0.338000													67	117					0	0	1	0	0
MAP3K14	9020	broad.mit.edu	37	17	43368222	43368222	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:43368222C>T	ENST00000344686.2	-	0	89							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						AAGGCAGGGGCAAAGGGTCTC	0.527000													5	13					0	0	1	0	0
ALAS1	211	broad.mit.edu	37	3	52239947	52239947	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52239947C>T	ENST00000394965.2	+	7	1253	c.893C>T	c.(892-894)gCa>gTa	p.A298V	ALAS1_ENST00000310271.2_Missense_Mutation_p.A298V|ALAS1_ENST00000484952.1_Missense_Mutation_p.A298V|ALAS1_ENST00000469224.1_Missense_Mutation_p.A298V	NM_000688.5	NP_000679.1	P13196	HEM1_HUMAN	aminolevulinate, delta-, synthase 1	298					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			endometrium(3)|kidney(3)|large_intestine(7)|liver(2)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CGGGAGCTGGCAGACCTCCAT	0.483000													35	54					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143096842	143096842	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:143096842C>T	ENST00000275815.3	-	4	823	c.737G>A	c.(736-738)cGc>cAc	p.R246H		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	246	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GCAGTGCATGCGGGGTGCACC	0.667000													9	18					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59789729	59789729	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:59789729C>T	ENST00000395125.1	+	5	583	c.560C>T	c.(559-561)gCg>gTg	p.A187V	DAAM1_ENST00000360909.3_Missense_Mutation_p.A187V|DAAM1_ENST00000351081.1_Missense_Mutation_p.A187V	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	187	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		TGTATAAAGGCGTTAATGAAC	0.438000													16	24					0	0	1	0	0
FBXO42	54455	broad.mit.edu	37	1	16577707	16577707	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16577707G>A	ENST00000375592.3	-	10	1828	c.1612C>T	c.(1612-1614)Cat>Tat	p.H538Y		NM_018994.1	NP_061867.1	Q6P3S6	FBX42_HUMAN	F-box protein 42	538								p.H538Y(1)		autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	26		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		GGTGGGGTATGCACACCATTT	0.577000													22	48					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61498026	61498026	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61498026C>T	ENST00000424789.2	+	25	4687	c.4683C>T	c.(4681-4683)ccC>ccT	p.P1561P	TANC2_ENST00000389520.4_Silent_p.P1571P|RP11-269G24.3_ENST00000583552.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1561							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CTGGTTCACCCGTGCGCTATC	0.582000													12	8					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9967951	9967951	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9967951C>T	ENST00000264833.4	-	4	753	c.568G>A	c.(568-570)Gcc>Acc	p.A190T	OLFM2_ENST00000590841.1_Missense_Mutation_p.A112T	NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	190						extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						AGCTTCTGGGCGCAGGCGTGG	0.627000													17	20					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49420343	49420343	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49420343G>A	ENST00000301067.7	-	48	15405	c.15406C>T	c.(15406-15408)Cat>Tat	p.H5136Y		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TTGATCTTATGCATTGGACAC	0.522000													39	51					0	0	1	0	0
ASB14	0	broad.mit.edu	37	3	57312473	57312473	+	Missense_Mutation	SNP	G	G	A	rs141550235		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:57312473G>A	ENST00000487349.1	-	8	1483	c.1363C>T	c.(1363-1365)Cat>Tat	p.H455Y	ASB14_ENST00000389601.3_Missense_Mutation_p.H455Y	NM_001142733.2|NM_130387.5	NP_001136205.2|NP_569058.1	A6NK59	ASB14_HUMAN	ankyrin repeat and SOCS box containing 14	455					intracellular signal transduction					central_nervous_system(1)|large_intestine(1)|lung(1)|skin(2)	5				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		TTGTCTCCATGTGGGCAATCA	0.433000													5	115					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	5956310	5956310	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:5956310G>A	ENST00000284898.6	-	20	1981	c.1781C>T	c.(1780-1782)gCa>gTa	p.A594V	RP11-793A3.1_ENST00000577704.1_RNA|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.A585V|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.A594V|L3MBTL4_ENST00000535782.1_Missense_Mutation_p.A398V	NM_173464.3	NP_775735.2	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	594	SAM.				chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				AATCTTCAGTGCTGGGCCCAG	0.468000													20	124					0	0	1	0	0
ZNF833P	0	broad.mit.edu	37	19	11796424	11796424	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11796424G>T	ENST00000344893.3	+	0	2423					NR_028594.1															endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	5						AAGGAATGTGGGAAAACATTC	0.363000													22	35					3.62473e-10	3.8659e-10	1	1	0
PPP6R2	9701	broad.mit.edu	37	22	50876706	50876706	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50876706C>T	ENST00000359139.3	+	17	2256	c.1862C>T	c.(1861-1863)gCc>gTc	p.A621V	PPP6R2_ENST00000395744.3_Missense_Mutation_p.A621V|PPP6R2_ENST00000395741.3_Missense_Mutation_p.A622V|PPP6R2_ENST00000216061.5_Missense_Mutation_p.A648V	NM_001242898.1|NM_001242899.1|NM_001242900.1|NM_014678.4	NP_001229827.1|NP_001229828.1|NP_001229829.1|NP_055493.2	O75170	PP6R2_HUMAN	protein phosphatase 6, regulatory subunit 2	648						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	22						CGCTGTGCTGCCCGGGTGATG	0.627000													5	80					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	784318	784318	+	Missense_Mutation	SNP	C	C	T	rs141751860		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:784318C>T	ENST00000540986.1	-	5	1733	c.298G>A	c.(298-300)Ggc>Agc	p.G100S	HAGHL_ENST00000569604.1_3'UTR|NARFL_ENST00000568545.1_Missense_Mutation_p.G100S|NARFL_ENST00000301694.5_Silent_p.T157T|NARFL_ENST00000251588.2_Missense_Mutation_p.G202S			Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	202					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				ATGAAGCTGCCGTGAGTCTTC	0.687000													11	16					0	0	1	0	0
KCNV2	169522	broad.mit.edu	37	9	2718473	2718473	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:2718473G>A	ENST00000382082.3	+	1	972	c.734G>A	c.(733-735)cGc>cAc	p.R245H		NM_133497.3	NP_598004.1	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	245						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	35				GBM - Glioblastoma multiforme(50;0.0257)		CAGCGGCGCCGCCTCTGGAAC	0.687000													3	3					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57596234	57596234	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57596234G>A	ENST00000243077.3	+	68	11091	c.10625G>A	c.(10624-10626)cGc>cAc	p.R3542H		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3542	LDL-receptor class A 26.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TACCAGTTCCGCTGCAAGAAC	0.607000													8	28					0	0	1	0	0
CNOT10	25904	broad.mit.edu	37	3	32811431	32811431	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:32811431C>T	ENST00000328834.5	+	18	2373	c.2057C>T	c.(2056-2058)gCa>gTa	p.A686V	CNOT10_ENST00000454516.2_Missense_Mutation_p.A746V|CNOT10_ENST00000331889.6_Missense_Mutation_p.A659V	NM_015442.2	NP_056257.1	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	686					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(3)	23						ATCTTGCTGGCAGTCTACCTT	0.453000													26	34					0	0	1	0	0
GSR	2936	broad.mit.edu	37	8	30553908	30553908	+	Missense_Mutation	SNP	G	G	A	rs140665617		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:30553908G>A	ENST00000221130.5	-	7	874	c.784C>T	c.(784-786)Cgg>Tgg	p.R262W	GSR_ENST00000541648.1_Missense_Mutation_p.R262W|GSR_ENST00000546342.1_Missense_Mutation_p.R262W|GSR_ENST00000414019.1_Missense_Mutation_p.R219W|GSR_ENST00000537535.1_Missense_Mutation_p.R262W	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	262					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TTATCATGCCGTATCATCAGT	0.423000													39	47					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23292175	23292175	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:23292175G>A	ENST00000298032.5	+	13	1647	c.1562_splice	c.e13-1	p.G521_splice	ARMC3_ENST00000376528.4_Splice_Site_p.G258_splice|ARMC3_ENST00000409049.3_Splice_Site_p.G521_splice|ARMC3_ENST00000409983.3_Splice_Site_p.G521_splice	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	521							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TTATTGACAGGGCTTTAGATA	0.363000													19	35					0	0	1	0	0
PKN2	5586	broad.mit.edu	37	1	89236101	89236101	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:89236101C>T	ENST00000370521.3	+	4	930	c.571C>T	c.(571-573)Cga>Tga	p.R191*	PKN2_ENST00000316005.7_Nonsense_Mutation_p.R191*|PKN2_ENST00000370505.3_Nonsense_Mutation_p.R34*|PKN2_ENST00000370513.5_Nonsense_Mutation_p.R191*	NM_006256.2	NP_006247.1	Q16513	PKN2_HUMAN	protein kinase N2	191					signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(1)	33		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		AGAAGTCATACGAATGCAGAT	0.363000													25	34					0	0	1	0	0
SEMG2	6407	broad.mit.edu	37	20	43851292	43851292	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:43851292G>A	ENST00000372769.3	+	2	1109	c.1019G>A	c.(1018-1020)gGc>gAc	p.G340D		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	340	4 X 60 AA tandem repeats, type I.|Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				CAAGAGCATGGCCATAAGGAA	0.378000													18	41					0	0	1	0	0
SMAD7	4092	broad.mit.edu	37	18	46447865	46447865	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:46447865C>T	ENST00000262158.2	-	4	1444	c.1158G>A	c.(1156-1158)atG>atA	p.M386I	SMAD7_ENST00000591805.1_Missense_Mutation_p.M171I|SMAD7_ENST00000589634.1_Missense_Mutation_p.M385I	NM_001190821.1|NM_005904.3	NP_001177750.1|NP_005895.1	O15105	SMAD7_HUMAN	SMAD family member 7	386	MH2.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	10	Colorectal(1;0.0518)					ACGGCTGCTGCATAAACTCGT	0.592000													9	19					0	0	1	0	0
KLHL17	339451	broad.mit.edu	37	1	898630	898630	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:898630G>A	ENST00000338591.3	+	7	1291	c.1184G>A	c.(1183-1185)gGc>gAc	p.G395D		NM_198317.2	NP_938073.1	Q6TDP4	KLH17_HUMAN	kelch-like family member 17	395	Interaction with F-actin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold			central_nervous_system(1)|kidney(2)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TATGCTGTGGGCGGGTAAGCC	0.672000													8	8					0	0	1	0	0
CD14	929	broad.mit.edu	37	5	140012544	140012544	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140012544G>A	ENST00000302014.6	-	2	654	c.25C>T	c.(25-27)Ctg>Ttg	p.L9L	CD14_ENST00000401743.2_Silent_p.L9L	NM_000591.3	NP_000582.1	P08571	CD14_HUMAN	CD14 molecule	9					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAGCAGCAGCAACAAGCAG	0.632000													7	14					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135908034	135908034	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:135908034C>T	ENST00000264158.8	+	18	2062	c.2019C>T	c.(2017-2019)cgC>cgT	p.R673R	RAB3GAP1_ENST00000487003.1_3'UTR|RAB3GAP1_ENST00000442034.1_Silent_p.R673R|RAB3GAP1_ENST00000539493.1_Silent_p.R629R|ZRANB3_ENST00000412849.1_Intron	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	673						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		TTCGAGCACGCATGCAGAGTG	0.488000													25	34					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52926984	52926984	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:52926984G>A	ENST00000295213.4	+	3	604	c.230G>A	c.(229-231)cGc>cAc	p.R77H	SPATA18_ENST00000506829.1_Intron|SPATA18_ENST00000419395.2_Missense_Mutation_p.R77H	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	77					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			ATCAAGTCACGCCTTTTGCCT	0.468000													20	24					0	0	1	0	0
FAM89B	23625	broad.mit.edu	37	11	65341082	65341082	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65341082G>A	ENST00000316409.2	+	2	822	c.501G>A	c.(499-501)tgG>tgA	p.W167*	FAM89B_ENST00000449319.2_3'UTR|FAM89B_ENST00000530349.1_Nonsense_Mutation_p.W180*	NM_001098784.1|NM_001098785.1|NM_152832.2	NP_001092254.1|NP_001092255.1|NP_690045.1	Q8N5H3	FA89B_HUMAN	family with sequence similarity 89, member B	167										large_intestine(1)|urinary_tract(2)	3						GTGACCAGTGGCTGCAGGATG	0.652000													13	28					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71068946	71068946	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:71068946A>G	ENST00000452400.2	-	11	1835	c.1654T>C	c.(1654-1656)Ttg>Ctg	p.L552L	NCOA2_ENST00000524223.1_Intron	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	552					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GGTGAAGCCAACGATGACCCT	0.498000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								7	62					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113496245	113496245	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:113496245G>A	ENST00000257600.3	+	1	751	c.248G>A	c.(247-249)cGc>cAc	p.R83H		NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	83	WWE 1.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						CACCAGTTTCGCCAGGACACA	0.612000													26	47					0	0	1	0	0
SETMAR	6419	broad.mit.edu	37	3	4354786	4354786	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:4354786C>A	ENST00000358065.4	+	2	428	c.361C>A	c.(361-363)Ctg>Atg	p.L121M	SUMF1_ENST00000534863.1_Intron|SETMAR_ENST00000430981.1_Missense_Mutation_p.L121M|SETMAR_ENST00000425863.1_Missense_Mutation_p.L121M	NM_006515.3	NP_006506.3	Q53H47	SETMR_HUMAN	SET domain and mariner transposase fusion gene	108	Histone-lysine N-methyltransferase.|Pre-SET.				DNA integration|DNA repair|transposition, DNA-mediated	chromosome|nucleus	DNA binding|endonuclease activity|histone-lysine N-methyltransferase activity|transposase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)	9		Melanoma(143;0.0657)		Epithelial(13;0.0025)|OV - Ovarian serous cystadenocarcinoma(96;0.011)|all cancers(10;0.0114)		ATGCAATGTCCTGTGCCGATG	0.473000								Chromatin Structure					7	13					5.18039e-06	5.37127e-06	1	1	0
ASB8	0	broad.mit.edu	37	12	48543494	48543494	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48543494G>A	ENST00000317697.3	-	4	691	c.522C>T	c.(520-522)ggC>ggT	p.G174G	ASB8_ENST00000536953.1_3'UTR|ASB8_ENST00000536549.1_Silent_p.G174G|ASB8_ENST00000539528.1_3'UTR|ASB8_ENST00000537754.1_5'UTR	NM_024095.3	NP_077000.1	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box containing 8	174					intracellular signal transduction	cytoplasm|nucleus		p.G174G(1)		breast(1)|kidney(2)|large_intestine(2)|lung(5)|soft_tissue(1)	11						TGACCTCTGCGCCATAATCCA	0.532000													22	42					0	0	1	0	0
RNF220	55182	broad.mit.edu	37	1	45091982	45091982	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:45091982C>A	ENST00000355387.2	+	5	1268	c.818C>A	c.(817-819)tCt>tAt	p.S273Y	RNF220_ENST00000361799.2_Missense_Mutation_p.S273Y|RNF220_ENST00000443020.2_Missense_Mutation_p.S34Y|RNF220_ENST00000372247.2_Missense_Mutation_p.S273Y			Q5VTB9	RN220_HUMAN	ring finger protein 220	273					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						CTCCTGTTGTCTGCTTCCATC	0.542000													10	31					7.48243e-07	7.8103e-07	1	1	0
SCN9A	6335	broad.mit.edu	37	2	167141099	167141099	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:167141099G>A	ENST00000303354.6	-	12	2181	c.1841C>T	c.(1840-1842)cCg>cTg	p.P614L	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.P613L|SCN9A_ENST00000375387.4_Missense_Mutation_p.P614L|SCN9A_ENST00000409435.1_Missense_Mutation_p.P613L			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	613						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CCCGTTCACCGGCAGCATTGG	0.587000													26	39					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15512454	15512454	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:15512454C>T	ENST00000341776.2	+	14	3212	c.2968C>T	c.(2968-2970)Ctg>Ttg	p.L990L	JARID2_ENST00000397311.3_Silent_p.L818L	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	990	JmjC.				central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CCCGGAGGTGCTGTGCAAAGA	0.607000													8	13					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31921246	31921246	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:31921246C>A	ENST00000396556.2	-	2	480	c.358G>T	c.(358-360)Gga>Tga	p.G120*	OSBPL10_ENST00000438237.2_Nonsense_Mutation_p.G120*	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	120	PH.				lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		GACAGGACTCCTCGAGGCTTC	0.488000													5	34					0.014758	0.0148771	1	1	0
KLF13	51621	broad.mit.edu	37	15	31664246	31664246	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:31664246G>A	ENST00000307145.3	+	2	969	c.611G>A	c.(610-612)tGc>tAc	p.C204Y	KLF13_ENST00000560473.1_Missense_Mutation_p.C16Y	NM_015995.2	NP_057079.2	Q9Y2Y9	KLF13_HUMAN	Kruppel-like factor 13	204					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)	2		all_lung(180;3.71e-11)		all cancers(64;1.11e-18)|Epithelial(43;1.73e-14)|GBM - Glioblastoma multiforme(186;0.00016)|Colorectal(1;0.00158)|BRCA - Breast invasive adenocarcinoma(123;0.00255)|COAD - Colon adenocarcinoma(236;0.0446)|READ - Rectum adenocarcinoma(1;0.13)|Lung(196;0.171)		TGGCAGGACTGCAACAAGAAG	0.642000													3	6					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11024683	11024683	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11024683G>A	ENST00000327064.4	+	6	990	c.800G>A	c.(799-801)cGc>cAc	p.R267H	CARM1_ENST00000344150.4_Missense_Mutation_p.R267H	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	267					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						TTCAACGAGCGCATGCTGGAG	0.642000													8	8					0	0	1	0	0
TCF7L2	6934	broad.mit.edu	37	10	114903764	114903764	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:114903764G>A	ENST00000545257.1	+	7	1275	c.768G>A	c.(766-768)ccG>ccA	p.P256P	TCF7L2_ENST00000538897.1_Silent_p.P256P|TCF7L2_ENST00000369389.1_5'UTR|TCF7L2_ENST00000355717.4_Silent_p.P280P|TCF7L2_ENST00000369395.1_Silent_p.P281P|TCF7L2_ENST00000542695.1_5'UTR|TCF7L2_ENST00000534894.1_Silent_p.P256P|TCF7L2_ENST00000355995.4_Silent_p.P256P|TCF7L2_ENST00000352065.5_Silent_p.P233P|TCF7L2_ENST00000543371.1_Silent_p.P256P|TCF7L2_ENST00000369397.4_Silent_p.P233P|TCF7L2_ENST00000349937.2_Silent_p.P256P|TCF7L2_ENST00000536810.1_Silent_p.P256P			Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 (T-cell specific, HMG-box)	256	Mediates interaction with MAD2L2.|Pro-rich.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding		VTI1A/TCF7L2(8)	central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(24)|liver(2)|lung(8)|ovary(1)|skin(1)	41		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		TCCCCCATCCGCTAGGATGGT	0.463000			T	VTI1A	colorectal								16	25					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77906603	77906603	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:77906603G>T	ENST00000355300.6	-	2	1820	c.1646C>A	c.(1645-1647)cCt>cAt	p.P549H	LINGO1_ENST00000561030.1_Missense_Mutation_p.P543H	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	549					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						GAAGGGGAAAGGCACAGTGGC	0.607000													16	26					2.23348e-06	2.32236e-06	1	1	0
MVP	9961	broad.mit.edu	37	16	29842219	29842219	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:29842219G>A	ENST00000357402.5	+	3	284	c.146G>A	c.(145-147)cGc>cAc	p.R49H	MVP_ENST00000566554.1_3'UTR|MVP_ENST00000395353.1_Missense_Mutation_p.R49H|MVP_ENST00000452209.2_Intron	NM_005115.4|NM_017458.3	NP_005106.2|NP_059447.2	Q14764	MVP_HUMAN	major vault protein	49					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(7)|ovary(2)|skin(3)|soft_tissue(1)|stomach(1)	27						GCCCCCATGCGCATGGTGACC	0.577000													9	17					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41601670	41601670	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:41601670C>T	ENST00000330436.3	+	9	1309	c.1309C>T	c.(1309-1311)Cgg>Tgg	p.R437W		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	437					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding	p.R437W(1)		breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	CTCAGGAAAGCGGTACTGTTT	0.572000													27	26					0	0	1	0	0
AHI1	54806	broad.mit.edu	37	6	135639719	135639719	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:135639719G>A	ENST00000367800.4	-	24	3580	c.3364C>T	c.(3364-3366)Cga>Tga	p.R1122*	AHI1_ENST00000457866.2_Nonsense_Mutation_p.R1122*|AHI1_ENST00000417892.2_Nonsense_Mutation_p.R476*	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	1122						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		GGAGGGGATCGCTCCTTTATC	0.383000													8	8					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	458033	458033	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:458033C>A	ENST00000512944.1	+	6	1372	c.1183C>A	c.(1183-1185)Ctg>Atg	p.L395M	EXOC3_ENST00000315013.5_Missense_Mutation_p.L395M	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	406					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CATCGCCTGGCTGCGGAAAGC	0.522000													9	5					3.09899e-07	3.24337e-07	1	1	0
PLXNB2	23654	broad.mit.edu	37	22	50728217	50728217	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50728217C>T	ENST00000449103.1	-	3	937	c.797G>A	c.(796-798)tGc>tAc	p.C266Y	PLXNB2_ENST00000359337.4_Missense_Mutation_p.C266Y			O15031	PLXB2_HUMAN	plexin B2	266	Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGGGTCCCGGCACTGCAGGTC	0.647000													6	21					0	0	1	0	0
P2RY6	0	broad.mit.edu	37	11	73008421	73008421	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:73008421G>A	ENST00000393590.2	+	2	1157	c.858G>A	c.(856-858)acG>acA	p.T286T	P2RY6_ENST00000540342.1_Silent_p.T286T|P2RY6_ENST00000540124.1_Silent_p.T286T|P2RY6_ENST00000542092.1_Silent_p.T286T|P2RY6_ENST00000538328.1_Silent_p.T286T|P2RY6_ENST00000349767.2_Silent_p.T286T|P2RY6_ENST00000393592.2_Silent_p.T286T|P2RY6_ENST00000393591.1_Silent_p.T286T	NM_001277207.1|NM_001277208.1	NP_001264136.1|NP_001264137.1	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y, G-protein coupled, 6	286					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)	14						ACAAAGGCACGCGGCCGTTTG	0.597000													25	35					0	0	1	0	0
CORO6	84940	broad.mit.edu	37	17	27943827	27943827	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27943827C>T	ENST00000345068.5	-	8	1110	c.897G>A	c.(895-897)gaG>gaA	p.E299E	RP11-68I3.2_ENST00000581474.1_RNA|CORO6_ENST00000388767.3_Silent_p.E299E|CORO6_ENST00000584969.1_Silent_p.E299E|CORO6_ENST00000577909.1_5'UTR|CORO6_ENST00000580212.1_Silent_p.E259E|CORO6_ENST00000445145.2_Silent_p.E299E|CORO6_ENST00000456796.3_Silent_p.E65E			Q6QEF8	CORO6_HUMAN	coronin 6	299					actin cytoskeleton organization	actin cytoskeleton	actin filament binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(2)	14						CGAAAGGCGGCTCGTCGGTAA	0.582000													34	56					0	0	1	0	0
ESCO1	114799	broad.mit.edu	37	18	19140885	19140885	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:19140885T>C	ENST00000269214.5	-	8	2825	c.1888A>G	c.(1888-1890)Aat>Gat	p.N630D		NM_052911.2	NP_443143.2	Q5FWF5	ESCO1_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 1	630					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			breast(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(10)|prostate(3)|upper_aerodigestive_tract(1)	35						TCTTCTGGATTTGAAGCTGTA	0.328000													8	55					0	0	1	0	0
TRUB2	26995	broad.mit.edu	37	9	131073259	131073259	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:131073259C>T	ENST00000372890.4	-	7	910	c.577G>A	c.(577-579)Gcc>Acc	p.A193T	TRUB2_ENST00000546104.1_Missense_Mutation_p.A137T|TRUB2_ENST00000460320.1_5'UTR	NM_015679.1	NP_056494.1	O95900	TRUB2_HUMAN	TruB pseudouridine (psi) synthase family member 2	193					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			kidney(2)|large_intestine(2)|lung(3)|ovary(1)	8						CCTCTCACGGCCATCTCATAG	0.582000													28	52					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64728820	64728820	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:64728820C>T	ENST00000413366.3	+	9	959	c.933C>T	c.(931-933)ggC>ggT	p.G311G		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	311					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	CCAAACTTGGCCCTGCTGGCA	0.448000													56	232					0	0	1	0	0
VPREB1	7441	broad.mit.edu	37	22	22599404	22599404	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:22599404G>A	ENST00000403807.3	+	2	232	c.93G>A	c.(91-93)tcG>tcA	p.S31S	VPREB1_ENST00000302273.2_Silent_p.S30S			P12018	VPREB_HUMAN	pre-B lymphocyte 1	31	Framework-1.|Ig-like V-type.				immune response	extracellular region	antigen binding|protein binding			large_intestine(1)|liver(1)|lung(6)|skin(1)	9	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		CCATGTCCTCGGCCCTTGGAA	0.642000													16	29					0	0	1	0	0
NFATC2IP	84901	broad.mit.edu	37	16	28975111	28975111	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:28975111C>T	ENST00000320805.4	+	8	1262	c.1187C>T	c.(1186-1188)aCa>aTa	p.T396I	NFATC2IP_ENST00000564978.1_Missense_Mutation_p.T117I|RP11-264B17.2_ENST00000569974.1_RNA|NFATC2IP_ENST00000568148.1_Missense_Mutation_p.T104I	NM_032815.3	NP_116204.3	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein	396	Ubiquitin-like.					cytoplasm|nucleus				breast(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(2)	11						TTTGATGGGACAAAGCTTTCA	0.572000													14	33					0	0	1	0	0
SUN5	140732	broad.mit.edu	37	20	31575487	31575487	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31575487C>T	ENST00000356173.3	-	10	800	c.708G>A	c.(706-708)caG>caA	p.Q236Q	SUN5_ENST00000375523.3_Silent_p.Q211Q	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	236	SUN.				spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						CGTCTGGGGGCTGTGCGTAGT	0.602000													7	6					0	0	1	0	0
OR10G3	26533	broad.mit.edu	37	14	22038126	22038126	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22038126G>A	ENST00000303532.1	-	1	749	c.750C>T	c.(748-750)acC>acT	p.T250T		NM_001005465.1	NP_001005465.1	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G, member 3	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T250T(1)		central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)	15	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		CATAGTACACGGTGACCACGG	0.572000													24	47					0	0	1	0	0
HOXA4	3201	broad.mit.edu	37	7	27169057	27169057	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:27169057G>A	ENST00000360046.5	-	2	815	c.750C>T	c.(748-750)caC>caT	p.H250H	HOXA4_ENST00000428284.2_Silent_p.H250H|HOXA3_ENST00000467897.2_5'UTR|HOXA-AS2_ENST00000521159.1_RNA	NM_002141.4	NP_002132.3	Q00056	HXA4_HUMAN	homeobox A4	250						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(6)	12						AACAGAGCGTGTGGGCGATCT	0.572000													25	51					0	0	1	0	0
LRWD1	222229	broad.mit.edu	37	7	102106412	102106412	+	Missense_Mutation	SNP	G	G	A	rs139115115		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:102106412G>A	ENST00000292616.5	+	2	381	c.229G>A	c.(229-231)Gcc>Acc	p.A77T		NM_152892.1	NP_690852.1	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain containing 1	77					chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|stomach(2)	20						CCTCCGCTGCGCCAACAACCA	0.632000													3	20					0	0	1	0	0
CHERP	10523	broad.mit.edu	37	19	16630047	16630047	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16630047C>T	ENST00000546361.2	-	17	2825	c.2674G>A	c.(2674-2676)Gac>Aac	p.D892N	CTD-3222D19.2_ENST00000409035.1_3'UTR|C19orf44_ENST00000221671.3_Intron|CHERP_ENST00000198939.6_Missense_Mutation_p.D903N|CHERP_ENST00000544299.1_5'UTR	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	892					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						TCATAGGGGTCATCCAGAGCC	0.632000													15	16					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135139756	135139756	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:135139756G>A	ENST00000372169.2	-	27	8173	c.7991C>T	c.(7990-7992)gCc>gTc	p.A2664V	SETX_ENST00000477049.1_5'UTR|SETX_ENST00000224140.5_Missense_Mutation_p.A2635V|SETX_ENST00000393220.1_Missense_Mutation_p.A2602V			Q7Z333	SETX_HUMAN	senataxin	2635	Necessary for nuclear localization.				cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GAAAGCCCTGGCCTCTCTCCT	0.607000													104	129					0	0	1	0	0
NELFB	25920	broad.mit.edu	37	9	140151431	140151431	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140151431C>T	ENST00000343053.4	+	4	859	c.522C>T	c.(520-522)agC>agT	p.S174S		NM_015456.3	NP_056271.2			negative elongation factor complex member B																		AGAAGGAGAGCGCTCTCTTCA	0.617000													29	38					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99481631	99481631	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:99481631G>A	ENST00000376460.1	-	43	4906	c.4826C>T	c.(4825-4827)aCg>aTg	p.T1609M	DOCK9_ENST00000339416.2_Missense_Mutation_p.T1610M|DOCK9_ENST00000448493.2_3'UTR	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1610	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GAGCTCGGGCGTGCTGGCATA	0.587000													8	10					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153216313	153216313	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153216313G>A	ENST00000310441.7	-	23	6620	c.5654C>T	c.(5653-5655)aCg>aTg	p.T1885M	HCFC1_ENST00000369984.4_Missense_Mutation_p.T1930M|HCFC1_ENST00000354233.3_Missense_Mutation_p.T1816M	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	1885					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGCAGGCACGTCTTAAAGGC	0.572000													56	18					0	0	1	0	0
HCFC2	29915	broad.mit.edu	37	12	104476381	104476381	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104476381C>T	ENST00000229330.4	+	6	975	c.871C>T	c.(871-873)Ctg>Ttg	p.L291L		NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	291					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						TTACCTAAATCTGGGTGAGTC	0.318000													21	32					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55620455	55620455	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:55620455A>G	ENST00000370830.3	-	7	1939	c.1241T>C	c.(1240-1242)gTa>gCa	p.V414A	BMP5_ENST00000446683.2_Missense_Mutation_p.V377A	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	414					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			AGGCTTTGGTACGTGGTCAGG	0.318000													37	49					0	0	1	0	0
GNPAT	8443	broad.mit.edu	37	1	231396268	231396268	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:231396268C>A	ENST00000366647.4	+	3	446	c.277C>A	c.(277-279)Ctt>Att	p.L93I	GNPAT_ENST00000366646.3_Missense_Mutation_p.L32I	NM_014236.3	NP_055051.1	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	93					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	23	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				CAAGGAATCCCTTCAATCTGT	0.408000													51	87					1.46357e-32	1.64217e-32	1	1	0
HLCS	3141	broad.mit.edu	37	21	38269241	38269241	+	Missense_Mutation	SNP	C	C	T	rs74574054	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:38269241C>T	ENST00000399120.1	-	7	2600	c.1370G>A	c.(1369-1371)cGc>cAc	p.R457H	HLCS_ENST00000336648.3_Missense_Mutation_p.R457H|HLCS_ENST00000482273.1_5'UTR	NM_001242784.1	NP_001229713.1	P50747	BPL1_HUMAN	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	457					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	CAGATTTTGGCGATAGATCTC	0.468000													5	27					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692605	135692605	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:135692605G>A	ENST00000513104.1	-	2	753	c.471C>T	c.(469-471)gaC>gaT	p.D157D	TRPC7_ENST00000426057.2_Silent_p.D157D|TRPC7_ENST00000355180.3_Silent_p.D157D	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	157					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGCGCGTGCCGTCCTCGTCGT	0.662000													21	75					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101969964	101969964	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:101969964C>A	ENST00000543253.1	+	5	1086	c.167C>A	c.(166-168)tCt>tAt	p.S56Y	GPRASP2_ENST00000332262.5_Missense_Mutation_p.S56Y|GPRASP2_ENST00000535209.1_Missense_Mutation_p.S56Y	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						GAGACCAAGTCTGTGCCTGCG	0.567000													26	5					4.26978e-12	4.60954e-12	1	1	0
TRAJ46	0	broad.mit.edu	37	14	22962402	22962402	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22962402C>T	ENST00000390491.1	+	0	14																											AGAAAAGCAGCGGAGACAAGC	0.473000													7	5					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	14665495	14665495	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:14665495G>A	ENST00000217246.4	+	5	703	c.308G>A	c.(307-309)gGc>gAc	p.G103D	MACROD2_ENST00000310348.4_Missense_Mutation_p.G103D|MACROD2_ENST00000464883.1_3'UTR	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	103	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				TTAGTGGATGGCTGTATTCAT	0.408000													30	67					0	0	1	0	0
C12orf52	84934	broad.mit.edu	37	12	113629387	113629387	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:113629387G>A	ENST00000548278.1	+	4	1267	c.575G>A	c.(574-576)cGc>cAc	p.R192H	C12orf52_ENST00000552495.1_Missense_Mutation_p.R216H|RP11-545P7.4_ENST00000552525.1_RNA|C12orf52_ENST00000549621.1_Missense_Mutation_p.R192H	NM_032848.1	NP_116237.1	Q96K30	RITA_HUMAN	chromosome 12 open reading frame 52	192	Interaction with tubulin.				negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding			large_intestine(2)|lung(1)|prostate(1)|urinary_tract(1)	5						CACTCTTCACGCCCCCTGAAG	0.612000													14	12					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10622544	10622544	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:10622544C>T	ENST00000547195.1	-	14	2165	c.1665G>A	c.(1663-1665)acG>acA	p.T555T	MRVI1_ENST00000552103.1_Silent_p.T555T|MRVI1_ENST00000423302.2_Silent_p.T646T|MRVI1_ENST00000436272.1_Silent_p.T619T|MRVI1_ENST00000558540.1_Silent_p.T331T|MRVI1_ENST00000545852.1_Silent_p.T331T|MRVI1_ENST00000424001.1_Silent_p.T331T|LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000527509.2_Silent_p.T555T|MRVI1_ENST00000534266.2_Silent_p.T331T|MRVI1_ENST00000421747.1_Silent_p.T637T|MRVI1_ENST00000531107.1_Silent_p.T638T|MRVI1_ENST00000541483.1_Silent_p.T440T	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	619					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CCTTCTCATACGTCCTCTTTA	0.522000													55	80					0	0	1	0	0
MRPL47	57129	broad.mit.edu	37	3	179320470	179320470	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:179320470T>C	ENST00000476781.1	-	2	243	c.214A>G	c.(214-216)Aaa>Gaa	p.K72E	MRPL47_ENST00000392659.2_Intron|MRPL47_ENST00000259038.2_Missense_Mutation_p.K52E	NM_020409.2	NP_065142.2	Q9HD33	RM47_HUMAN	mitochondrial ribosomal protein L47	72					translation	mitochondrial ribosome	structural constituent of ribosome			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|stomach(1)	11	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)			CCCCAGTTTTTTGGGTCATCA	0.418000													26	35					0	0	1	0	0
BTAF1	9044	broad.mit.edu	37	10	93722417	93722417	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:93722417C>T	ENST00000265990.6	+	12	1694	c.1386C>T	c.(1384-1386)gtC>gtT	p.V462V	BTAF1_ENST00000471217.1_3'UTR	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	462					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				AAAGCCTTGTCTATCTTCAGA	0.338000													27	41					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89801939	89801939	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:89801939C>T	ENST00000310775.7	+	3	175	c.89C>T	c.(88-90)aCt>aTt	p.T30I	FANCI_ENST00000451393.2_5'UTR|FANCI_ENST00000300027.8_Missense_Mutation_p.T30I|FANCI_ENST00000567996.1_Missense_Mutation_p.T30I	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	30					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					TTGCAGTTGACTAATCTCCTT	0.388000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				29	60					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44116566	44116566	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:44116566C>T	ENST00000259746.9	+	15	1480	c.1297C>T	c.(1297-1299)Cgc>Tgc	p.R433C	TMEM63B_ENST00000323267.6_Missense_Mutation_p.R433C			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	433						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CTGGTGGCTGCGCTGCCTGGT	0.582000													12	34					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104499708	104499708	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:104499708C>G	ENST00000361820.3	-	1	1154	c.554G>C	c.(553-555)tGc>tCc	p.C185S		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	185					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CACGGTATGGCACACACTTTG	0.597000													5	32					0	0	1	0	0
RSPH9	221421	broad.mit.edu	37	6	43623320	43623320	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43623320C>T	ENST00000372163.4	+	3	468	c.415C>T	c.(415-417)Cgc>Tgc	p.R139C	RSPH9_ENST00000372165.4_Intron	NM_152732.4	NP_689945.2	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog (Chlamydomonas)	139					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						GGAAGAGACCCGCTTGGTGTC	0.622000									Kartagener syndrome				51	90					0	0	1	0	0
HKR1	284459	broad.mit.edu	37	19	37854238	37854238	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:37854238C>T	ENST00000591471.1	+	9	2363	c.722C>T	c.(721-723)aCg>aTg	p.T241M	HKR1_ENST00000591134.1_Intron|HKR1_ENST00000544914.1_Missense_Mutation_p.T241M|HKR1_ENST00000324411.4_Missense_Mutation_p.T514M|HKR1_ENST00000541583.2_Missense_Mutation_p.T453M|HKR1_ENST00000392153.3_Missense_Mutation_p.T495M|HKR1_ENST00000589392.1_Missense_Mutation_p.T496M			P10072	HKR1_HUMAN	HKR1, GLI-Kruppel zinc finger family member	514					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACCCTGAGCACGCACCAGAGG	0.507000													14	34					0	0	1	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049500	90049500	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:90049500G>A	ENST00000330947.2	+	5	1651	c.1291G>A	c.(1291-1293)Ggt>Agt	p.G431S	RP5-1007M22.2_ENST00000443562.1_RNA|LRRC8B_ENST00000358200.4_Missense_Mutation_p.G431S|LRRC8B_ENST00000439853.1_Missense_Mutation_p.G431S	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	431						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		TATGCTCAACGGTCTTCCAGA	0.433000													21	44					0	0	1	0	0
CNDP2	55748	broad.mit.edu	37	18	72179721	72179721	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:72179721C>T	ENST00000324262.4	+	7	1012	c.696C>T	c.(694-696)taC>taT	p.Y232Y	CNDP2_ENST00000579847.1_Silent_p.Y232Y|CNDP2_ENST00000324301.8_Silent_p.Y148Y	NM_018235.2	NP_060705.2	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2 (metallopeptidase M20 family)	232						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity	p.Y232Y(1)		breast(1)|cervix(1)|endometrium(3)|large_intestine(7)|lung(5)|ovary(2)|skin(2)|stomach(3)	24		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		CTGGGGTGTACGGGGGCTCGG	0.542000													23	33					0	0	1	0	0
FGD3	89846	broad.mit.edu	37	9	95796900	95796900	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:95796900C>T	ENST00000375482.3	+	17	2359	c.1863C>T	c.(1861-1863)agC>agT	p.S621S	FGD3_ENST00000337352.6_Silent_p.S621S|FGD3_ENST00000416701.2_Silent_p.S620S|FGD3_ENST00000538555.1_Silent_p.S224S	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	621	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						AGACCTGGAGCGAGGTGTGGG	0.672000													12	24					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15760047	15760047	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:15760047C>T	ENST00000221307.7	+	6	651	c.603C>T	c.(601-603)gaC>gaT	p.D201D	CYP4F3_ENST00000585846.1_Silent_p.D201D|CYP4F3_ENST00000591058.1_Silent_p.D201D|CYP4F3_ENST00000586182.1_Silent_p.D201D	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	201					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						TGACCTTGGACAGTCTGCAGA	0.562000													33	46					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039262	31039262	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:31039262G>A	ENST00000355537.3	+	4	2883	c.2736G>A	c.(2734-2736)gtG>gtA	p.V912V		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	912					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GCAACGGTGTGAATTTCCAAG	0.498000													89	100					0	0	1	0	0
RHBDD2	57414	broad.mit.edu	37	7	75511511	75511511	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:75511511C>A	ENST00000318622.4	+	3	749	c.120C>A	c.(118-120)acC>acA	p.T40T	RHBDD2_ENST00000006777.6_Silent_p.T181T|RHBDD2_ENST00000468304.1_Intron|RHBDD2_ENST00000428119.1_Silent_p.T40T	NM_001040457.1	NP_001035547.1	Q6NTF9	RHBD2_HUMAN	rhomboid domain containing 2	181						integral to membrane	serine-type endopeptidase activity			kidney(1)|lung(4)|prostate(1)	6						TTCCCCAGACCTCTTTCCTCA	0.587000													13	22					5.01169e-05	5.15048e-05	1	1	0
SNX25	83891	broad.mit.edu	37	4	186188122	186188122	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:186188122G>A	ENST00000504273.1	+	5	706		c.e5-1		SNX25_ENST00000264694.8_Splice_Site			Q9H3E2	SNX25_HUMAN	sorting nexin 25						cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		TCTTCCTGTAGTCTTGAAGCC	0.398000													15	44					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234561461	234561461	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:234561461G>A	ENST00000040877.1	-	20	3401	c.3402C>T	c.(3400-3402)caC>caT	p.H1134H		NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1134					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			TAAACAACTTGTGGGACATAT	0.299000													23	23					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28229592	28229592	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:28229592C>T	ENST00000305242.5	-	13	1978	c.1886G>A	c.(1885-1887)cGc>cAc	p.R629H	ARMC4_ENST00000545014.1_Missense_Mutation_p.R154H|ARMC4_ENST00000537576.1_Missense_Mutation_p.R321H	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	629							binding	p.R629H(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						CCCAGCTTTGCGGATGGCTTC	0.532000													19	30					0	0	1	0	0
CHD6	0	broad.mit.edu	37	20	40033327	40033327	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:40033327C>T	ENST00000373233.3	-	37	8231	c.8054G>A	c.(8053-8055)tGt>tAt	p.C2685Y	CHD6_ENST00000480022.1_5'UTR	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2685					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				GGGTTCGGCACAGTTCTCATC	0.572000													24	54					0	0	1	0	0
PRSS12	8492	broad.mit.edu	37	4	119234369	119234369	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:119234369G>A	ENST00000296498.3	-	7	1758	c.1476C>T	c.(1474-1476)caC>caT	p.H492H		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	492						membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						GAGAGAGCCTGTGTCCCTCGC	0.532000													9	11					0	0	1	0	0
AKNAD1	254268	broad.mit.edu	37	1	109369845	109369845	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109369845G>A	ENST00000370001.3	-	11	2186	c.1918C>T	c.(1918-1920)Cac>Tac	p.H640Y	AKNAD1_ENST00000369994.1_Missense_Mutation_p.H610Y|AKNAD1_ENST00000369995.3_Missense_Mutation_p.H640Y|AKNAD1_ENST00000357393.4_Missense_Mutation_p.H347Y	NM_152763.4	NP_689976.2	Q5T1N1	AKND1_HUMAN	AKNA domain containing 1	640										breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|prostate(6)|skin(3)|stomach(2)	32						GAATCTGAGTGTGGTGCCTTT	0.488000													86	157					0	0	1	0	0
STX11	8676	broad.mit.edu	37	6	144508226	144508226	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:144508226C>T	ENST00000367568.4	+	2	645	c.462C>T	c.(460-462)cgC>cgT	p.R154R		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	154					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		TGAAGCAGCGCGACAACTGCA	0.622000									Familial Hemophagocytic Lymphohistiocytosis				7	15					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225796266	225796266	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:225796266T>C	ENST00000409592.3	-	2	338	c.225_splice	c.e2+1	p.S75_splice	DOCK10_ENST00000258390.7_Splice_Site_p.S81_splice|DOCK10_ENST00000474102.1_5'UTR			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	81							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GAAGACTTACTGAAAAGTCAT	0.458000													9	11					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55329795	55329795	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:55329795C>T	ENST00000536015.1	-	21	2457	c.2338G>A	c.(2338-2340)Gca>Aca	p.A780T	RP11-35G9.3_ENST00000591854.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.A780T|RP11-35G9.3_ENST00000599199.1_RNA|RP11-35G9.5_ENST00000588925.1_RNA|RP11-35G9.3_ENST00000592201.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	780					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				GCAAACTTTGCGTAGACGCCA	0.438000													7	72					0	0	1	0	0
ADAD2	161931	broad.mit.edu	37	16	84228124	84228124	+	Silent	SNP	G	G	A	rs143343092		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:84228124G>A	ENST00000268624.3	+	3	804	c.711G>A	c.(709-711)acG>acA	p.T237T	ADAD2_ENST00000315906.5_Silent_p.T165T|RP11-486L19.2_ENST00000536986.1_RNA|RP11-486L19.2_ENST00000561900.1_RNA|RP11-486L19.2_ENST00000565643.1_RNA	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	165					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						ATAGCAAGACGGAGGCCAAAC	0.642000													3	19					0	0	1	0	0
AAR2	25980	broad.mit.edu	37	20	34843606	34843606	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:34843606C>T	ENST00000373932.3	+	4	1440	c.1094C>T	c.(1093-1095)gCg>gTg	p.A365V	AAR2_ENST00000397286.3_Intron|AAR2_ENST00000320849.4_Missense_Mutation_p.A365V	NM_015511.3	NP_056326.2			AAR2 splicing factor homolog (S. cerevisiae)																		GACTTTGCTGCGGAACCTGAG	0.602000													12	63					0	0	1	0	0
C16orf89	146556	broad.mit.edu	37	16	5097896	5097896	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:5097896C>T	ENST00000315997.5	-	7	1139	c.938G>A	c.(937-939)cGa>cAa	p.R313Q	C16orf89_ENST00000422873.1_Missense_Mutation_p.R351Q|ALG1_ENST00000588623.1_Intron|C16orf89_ENST00000350219.4_Missense_Mutation_p.R351Q|C16orf89_ENST00000474471.3_Missense_Mutation_p.R345Q|C16orf89_ENST00000472572.3_Missense_Mutation_p.R313Q	NM_152459.4	NP_689672.4	Q6UX73	CP089_HUMAN	chromosome 16 open reading frame 89	313						extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	12						TTGTTTTTCTCGCCTCTTCAC	0.378000													24	55					0	0	1	0	0
UPF1	5976	broad.mit.edu	37	19	18976954	18976954	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18976954G>A	ENST00000262803.5	+	23	3611	c.3339G>A	c.(3337-3339)acG>acA	p.T1113T	UPF1_ENST00000599848.1_Silent_p.T1124T	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	1124	Gln/Ser-rich.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						GCGGGGTGACGGGGCTGTCCC	0.617000													8	32					0	0	1	0	0
PNISR	25957	broad.mit.edu	37	6	99849499	99849499	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:99849499C>T	ENST00000369239.5	-	12	1539	c.1335G>A	c.(1333-1335)aaG>aaA	p.K445K	PNISR_ENST00000438806.1_Silent_p.K445K	NM_032870.2	NP_116259.2	Q8TF01	PNISR_HUMAN	PNN-interacting serine/arginine-rich protein	445						nuclear speck				breast(2)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24						CTGTTTGCTGCTTTTCTTCTG	0.338000													8	26					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90144541	90144541	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:90144541C>T	ENST00000405460.2	+	79	17203	c.17107C>T	c.(17107-17109)Cgc>Tgc	p.R5703C	GPR98_ENST00000425867.2_Missense_Mutation_p.R1364C	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5703					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAACCCAAAGCGCAAGGACAC	0.403000													13	13					0	0	1	0	0
MBD3	53615	broad.mit.edu	37	19	1584643	1584643	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1584643G>A	ENST00000590550.2	-	2	509	c.136C>T	c.(136-138)Cgc>Tgc	p.R46C	MBD3_ENST00000585967.1_5'UTR|MBD3_ENST00000156825.1_Missense_Mutation_p.R102C|MBD3_ENST00000592012.1_Missense_Mutation_p.R70C|MBD3_ENST00000434436.3_Missense_Mutation_p.R102C			O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	102	MBD.				transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGTCTGGCGCACGGGCAGC	0.697000													10	20					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183510217	183510217	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:183510217G>T	ENST00000367537.3	+	14	1676	c.1481G>T	c.(1480-1482)tGg>tTg	p.W494L	SMG7_ENST00000347615.2_Missense_Mutation_p.W465L|SMG7_ENST00000515829.2_Missense_Mutation_p.W465L|SMG7_ENST00000507469.1_Missense_Mutation_p.W465L|SMG7_ENST00000508461.1_Missense_Mutation_p.W423L|SMG7_ENST00000456731.2_Missense_Mutation_p.W423L			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	465					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						ATAGGCAAATGGATTGCTGAT	0.473000													66	81					1.77791e-30	1.99291e-30	1	1	0
EGF	1950	broad.mit.edu	37	4	110902097	110902097	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:110902097G>A	ENST00000265171.5	+	15	2782	c.2337G>A	c.(2335-2337)acG>acA	p.T779T	EGF_ENST00000503392.1_Silent_p.T779T|EGF_ENST00000509793.1_Silent_p.T737T	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	779	EGF-like 5.				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ATGGGAAAACGTGTCTGGCTC	0.413000													77	97					0	0	1	0	0
ZNF572	137209	broad.mit.edu	37	8	125988686	125988686	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:125988686G>T	ENST00000319286.5	+	3	330	c.176G>T	c.(175-177)aGa>aTa	p.R59I		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	59					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R59T(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AAAAGACATAGACCACAACAT	0.373000										HNSCC(60;0.17)			21	35					4.54149e-19	5.02196e-19	1	1	0
PMPCA	23203	broad.mit.edu	37	9	139311571	139311571	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139311571C>T	ENST00000371717.3	+	7	811	c.802C>T	c.(802-804)Cgg>Tgg	p.R268W	PMPCA_ENST00000462616.1_3'UTR|PMPCA_ENST00000399219.3_Missense_Mutation_p.R137W	NM_015160.1	NP_055975.1	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	268					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|urinary_tract(1)	14		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		GGACTGTGCCCGGAAGTACCT	0.637000													9	14					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37059130	37059130	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:37059130A>T	ENST00000282516.8	+	44	8047	c.7548A>T	c.(7546-7548)gaA>gaT	p.E2516D	NIPBL_ENST00000448238.2_Missense_Mutation_p.E2516D	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2516					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			cagattcagaAGACGATATAA	0.383000													18	24					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75277322	75277322	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:75277322C>T	ENST00000339859.4	-	19	2962	c.2862G>A	c.(2860-2862)aaG>aaA	p.K954K	USP54_ENST00000497106.1_5'UTR|RP11-137L10.6_ENST00000600206.1_RNA|RP11-137L10.6_ENST00000593790.1_RNA|RP11-137L10.6_ENST00000595069.1_RNA|RP11-137L10.6_ENST00000597958.1_RNA|USP54_ENST00000408019.1_Silent_p.K954K|USP54_ENST00000422491.2_Silent_p.K136K|USP54_ENST00000428547.1_Silent_p.K804K|USP54_ENST00000394811.2_Silent_p.K42K			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	954					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					AAGTCAGAAGCTTCAAGGCAG	0.488000													12	22					0	0	1	0	0
ZNF833P	0	broad.mit.edu	37	19	11793385	11793385	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11793385G>A	ENST00000344893.3	+	0	1587					NR_028594.1															endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	5						TGAGGATGTGGCTGTGAACTT	0.488000													28	48					0	0	1	0	0
ZDHHC1	29800	broad.mit.edu	37	16	67429019	67429019	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67429019C>T	ENST00000348579.2	-	10	1457	c.1116G>A	c.(1114-1116)tcG>tcA	p.S372S	ZDHHC1_ENST00000566075.1_Intron	NM_013304.2	NP_037436.1	Q8WTX9	ZDHC1_HUMAN	zinc finger, DHHC-type containing 1	372						integral to membrane	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|urinary_tract(1)	10		Ovarian(137;0.223)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0178)|all cancers(182;5.71e-53)|Epithelial(162;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(108;1.53e-29)|Kidney(780;4.37e-05)|BRCA - Breast invasive adenocarcinoma(181;5.8e-05)|GBM - Glioblastoma multiforme(240;0.0022)		GAAGCAGAGGCGAGCGCCAGG	0.622000													4	6					0	0	1	0	0
ST6GALNAC2	10610	broad.mit.edu	37	17	74570475	74570475	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74570475C>T	ENST00000225276.5	-	3	652	c.333G>A	c.(331-333)ccG>ccA	p.P111P	ST6GALNAC2_ENST00000586520.1_5'UTR	NM_006456.2	NP_006447.2	Q9UJ37	SIA7B_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	111					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	11						GCCAGCCATACGGGGCTTTGT	0.627000													5	10					0	0	1	0	0
TSG101	7251	broad.mit.edu	37	11	18503234	18503234	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18503234G>T	ENST00000536719.1	-	9	1160	c.1026C>A	c.(1024-1026)atC>atA	p.I342I	TSG101_ENST00000251968.3_Silent_p.I342I|TSG101_ENST00000357193.3_Silent_p.I237I			Q99816	TS101_HUMAN	tumor susceptibility 101	342	SB.				cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	22						CCAAGTAAAAGATAGTGTCTT	0.393000													40	56					4.14481e-20	4.59174e-20	1	1	0
GDPD3	79153	broad.mit.edu	37	16	30116256	30116256	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30116256C>T	ENST00000406256.3	-	10	1271	c.894G>A	c.(892-894)acG>acA	p.T298T		NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	298	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						TGGGATAATCCGTTATGACGC	0.572000													6	10					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150704235	150704235	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150704235C>T	ENST00000297494.3	+	17	2340	c.1983C>T	c.(1981-1983)tgC>tgT	p.C661C	NOS3_ENST00000461406.1_Silent_p.C455C	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	661	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCCACTTCTGCGCCTTTGCTC	0.692000													45	76					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59821889	59821889	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:59821889G>A	ENST00000395125.1	+	20	2416	c.2393G>A	c.(2392-2394)cGt>cAt	p.R798H	DAAM1_ENST00000360909.3_Missense_Mutation_p.R788H|DAAM1_ENST00000553966.1_Intron|DAAM1_ENST00000351081.1_Missense_Mutation_p.R798H	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	798	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		GAAGCAATTCGTTCTGGCTCA	0.378000													45	49					0	0	1	0	0
SCARB2	950	broad.mit.edu	37	4	77091034	77091034	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:77091034C>T	ENST00000264896.2	-	8	1448	c.1099G>A	c.(1099-1101)Gtg>Atg	p.V367M	SCARB2_ENST00000452464.2_Missense_Mutation_p.V224M	NM_005506.3	NP_005497.1	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	367					cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(3)|prostate(2)|skin(1)	22			Lung(101;0.196)			TTAATGTCCACAAATGTCTCA	0.403000													31	60					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58286900	58286900	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:58286900G>A	ENST00000300896.4	-	22	2623	c.2429C>T	c.(2428-2430)aCc>aTc	p.T810I	USP32_ENST00000592339.1_Missense_Mutation_p.T480I	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	810					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TTTTGCTATGGTCCACTATAA	0.368000													45	55					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6948188	6948188	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6948188C>T	ENST00000251761.8	+	0	1963				LEPREL2_ENST00000396725.2_RNA|LEPREL2_ENST00000606935.1_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						TCGCTGTGGGCGCCTTGTGGC	0.662000													6	26					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018244	1018244	+	Silent	SNP	C	C	T	rs138109269		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1018244C>T	ENST00000398484.2	+	7	1444	c.864C>T	c.(862-864)gcC>gcT	p.A288A	FGFRL1_ENST00000510644.1_Silent_p.A288A|FGFRL1_ENST00000504138.1_Silent_p.A288A|FGFRL1_ENST00000264748.6_Silent_p.A288A			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	288	Ig-like C2-type 3.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			AGTACGGCGCCGAGGGCCGCC	0.657000													16	19					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133911650	133911650	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:133911650C>T	ENST00000361069.4	+	4	1040	c.907C>T	c.(907-909)Cgc>Tgc	p.R303C	LAMC3_ENST00000480883.1_3'UTR	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	303	Laminin EGF-like 1.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		AGACTGTGAGCGCTGCCTGCC	0.692000													29	29					0	0	1	0	0
SLC25A12	8604	broad.mit.edu	37	2	172671677	172671677	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:172671677C>A	ENST00000422440.2	-	10	1003	c.966G>T	c.(964-966)caG>caT	p.Q322H	SLC25A12_ENST00000392592.4_Missense_Mutation_p.Q215H	NM_003705.4	NP_003696.2	O75746	CMC1_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 12	322					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|upper_aerodigestive_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	ACTCGGCAATCTGGAGCCAGA	0.458000													28	44					9.65021e-13	1.04556e-12	1	1	0
CHST13	166012	broad.mit.edu	37	3	126260941	126260941	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:126260941G>A	ENST00000319340.2	+	3	596	c.546G>A	c.(544-546)tcG>tcA	p.S182S		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	182					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		GCCTGGCATCGGCTTACCGCA	0.711000													6	18					0	0	1	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973978	46973978	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46973978C>A	ENST00000313683.10	-	2	620	c.315G>T	c.(313-315)gaG>gaT	p.E105D	PNMAL1_ENST00000602246.1_Intron|PNMAL1_ENST00000438932.2_Missense_Mutation_p.E105D	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	105										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		tttttaaaaactcggcatcct	0.567000													8	48					3.09899e-07	3.24337e-07	1	1	0
MAP3K4	4216	broad.mit.edu	37	6	161505568	161505568	+	Missense_Mutation	SNP	G	G	A	rs142735217		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:161505568G>A	ENST00000392142.4	+	7	2439	c.2291G>A	c.(2290-2292)aGt>aAt	p.S764N	MAP3K4_ENST00000366920.2_Missense_Mutation_p.S764N|MAP3K4_ENST00000366919.2_Missense_Mutation_p.S764N|MAP3K4_ENST00000348824.7_Missense_Mutation_p.S764N	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	764					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TCTACAGGAAGTTTTTTAGAA	0.408000													24	49					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20618022	20618022	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:20618022A>G	ENST00000202677.6	-	8	932	c.790T>C	c.(790-792)Tac>Cac	p.Y264H		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	264					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						ACAGGTTTGTAGATGTTTGTT	0.318000													5	15					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74625190	74625190	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:74625190C>T	ENST00000156626.7	-	2	934	c.735G>A	c.(733-735)acG>acA	p.T245T	ST6GALNAC1_ENST00000590878.1_5'UTR	NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	245					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						GGTTTCTCTGCGTCGTGGGGC	0.542000													24	44					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34118619	34118619	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:34118619G>A	ENST00000297161.2	+	13	1603	c.1229G>A	c.(1228-1230)cGc>cAc	p.R410H	BMPER_ENST00000426693.1_Missense_Mutation_p.R410H	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	410	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						AACGACGCCCGCCGGACACGC	0.622000													28	46					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192711441	192711441	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:192711441C>T	ENST00000304141.4	-	1	540	c.211G>A	c.(211-213)Gct>Act	p.A71T	AC098617.1_ENST00000424116.2_RNA	NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	71						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TCCTGCACAGCGTCTAGCATG	0.567000													21	26					0	0	1	0	0
CLEC1B	51266	broad.mit.edu	37	12	10149866	10149866	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:10149866C>T	ENST00000428126.2	-	4	346	c.77G>A	c.(76-78)cGc>cAc	p.R26H	CLEC1B_ENST00000298527.6_Missense_Mutation_p.R59H|CLEC1B_ENST00000348658.4_Missense_Mutation_p.R26H			Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B	59					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(12)|stomach(1)|urinary_tract(1)	19						TAGGTAATTGCGCTGCATGAC	0.348000													5	23					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23226476	23226476	+	Missense_Mutation	SNP	G	G	A	rs143742457		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:23226476G>A	ENST00000300061.2	+	13	1779	c.1636G>A	c.(1636-1638)Gtc>Atc	p.V546I		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	546					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TGTTGTCTGCGTCATCGAGAT	0.552000													12	19					0	0	1	0	0
EME2	197342	broad.mit.edu	37	16	1825080	1825080	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1825080C>T	ENST00000307394.7	+	4	516	c.516C>T	c.(514-516)ccC>ccT	p.P172P	EME2_ENST00000568449.1_Silent_p.P172P			A4GXA9	EME2_HUMAN	essential meiotic structure-specific endonuclease subunit 2	172					DNA recombination|DNA repair	nucleus	DNA binding|endonuclease activity			central_nervous_system(1)|kidney(2)|lung(5)|pancreas(1)	9						GGATCTCCCCCGAGACCACCG	0.652000								Direct reversal of damage;Homologous recombination					32	104					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11061942	11061942	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:11061942G>A	ENST00000536032.1	+	0	289				SLC6A1_ENST00000287766.4_Missense_Mutation_p.R172H			P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1						neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	AACACAGACCGCTGCTTCTCC	0.592000													10	16					0	0	1	0	0
HIBCH	26275	broad.mit.edu	37	2	191161561	191161561	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:191161561C>T	ENST00000392332.3	-	3	336	c.197G>A	c.(196-198)cGg>cAg	p.R66Q	HIBCH_ENST00000359678.5_Missense_Mutation_p.R66Q			Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-CoA hydrolase	66					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding			NS(1)|breast(2)|endometrium(1)|large_intestine(1)|lung(5)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			ATAAATCTGCCGAATCATATT	0.358000													7	56					0	0	1	0	0
ZNF45	7596	broad.mit.edu	37	19	44418988	44418988	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44418988G>T	ENST00000269973.5	-	10	1690	c.600C>A	c.(598-600)gcC>gcA	p.A200A	ZNF45_ENST00000589703.1_Silent_p.A200A|RP11-15A1.2_ENST00000586247.1_RNA	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	200					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						ACCGACGGAAGGCATTATCAC	0.418000													56	104					2.23044e-30	2.49988e-30	1	1	0
MTMR8	55613	broad.mit.edu	37	X	63488627	63488627	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:63488627G>A	ENST00000374852.3	-	14	1972	c.1905C>T	c.(1903-1905)ggC>ggT	p.G635G	MTMR8_ENST00000453546.1_Intron	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	635						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						CTCCAGAGATGCCCATGGCCT	0.537000													17	16					0	0	1	0	0
EPHB6	0	broad.mit.edu	37	7	142562205	142562205	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142562205C>T	ENST00000392957.2	+	7	1434	c.647C>T	c.(646-648)aCg>aTg	p.T216M	EPHB6_ENST00000442129.1_Missense_Mutation_p.T216M|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	216						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity	p.T201M(1)		NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					TTCCAGGACACGGGGGCCTGC	0.657000													55	41					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65178558	65178558	+	Silent	SNP	C	C	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:65178558C>G	ENST00000310045.7	-	2	4791	c.3318G>C	c.(3316-3318)gtG>gtC	p.V1106V	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1096						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				ACAAGAGGGACACTGCATTTG	0.393000													9	86					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40843385	40843385	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:40843385C>T	ENST00000254691.5	+	2	614	c.415C>T	c.(415-417)Cac>Tac	p.H139Y	CARD6_ENST00000381677.3_Missense_Mutation_p.H139Y	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	139					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						TGAGAAGGAACACTTGGATTT	0.428000													9	52					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7059988	7059988	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7059988C>T	ENST00000299481.4	+	2	517	c.171C>T	c.(169-171)gaC>gaT	p.D57D		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	57	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GGCGGGAGGACCTGGCCAATT	0.453000													12	29					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109779684	109779684	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:109779684C>T	ENST00000356711.2	+	31	3897	c.3771C>T	c.(3769-3771)tgC>tgT	p.C1257C	MYO16_ENST00000357550.2_Silent_p.C1257C|MYO16_ENST00000457511.2_Silent_p.C769C	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1257					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TGTCAGTCTGCGCGGCCGTGG	0.607000													5	6					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88284431	88284431	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:88284431G>A	ENST00000357081.3	-	8	775	c.631C>T	c.(631-633)Cca>Tca	p.P211S	AGTPBP1_ENST00000376109.3_Missense_Mutation_p.P263S|AGTPBP1_ENST00000376083.3_Missense_Mutation_p.P211S|AGTPBP1_ENST00000337006.4_Missense_Mutation_p.P153S|AGTPBP1_ENST00000491784.1_5'UTR|AGTPBP1_ENST00000432218.1_Missense_Mutation_p.P49S|AGTPBP1_ENST00000376080.1_Missense_Mutation_p.P153S|AGTPBP1_ENST00000376081.4_Missense_Mutation_p.P211S			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	211					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						TTACTAAATGGTCCAATGATT	0.348000													8	58					0	0	1	0	0
AK2	204	broad.mit.edu	37	1	33486968	33486968	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33486968C>A	ENST00000373449.2	-	4	466	c.425_splice	c.e4+1	p.R142_splice	AK2_ENST00000354858.6_Splice_Site_p.R142_splice|RP1-117O3.2_ENST00000427524.1_RNA|AK2_ENST00000548033.1_Splice_Site_p.R100_splice|AK2_ENST00000480134.1_Intron|AK2_ENST00000487289.1_Splice_Site_p.S142_splice|AK2_ENST00000467905.1_Splice_Site_p.R142_splice	NM_001199199.1|NM_013411.4	NP_001186128.1|NP_037543.1	P54819	KAD2_HUMAN	adenylate kinase 2	142					nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				GGACAAATACCTTCCTGTGAT	0.453000													34	31					8.73648e-17	9.60375e-17	1	1	0
UNC5B	219699	broad.mit.edu	37	10	73055655	73055655	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:73055655C>T	ENST00000335350.6	+	14	2679	c.2263C>T	c.(2263-2265)Cgc>Tgc	p.R755C	UNC5B_ENST00000373192.4_Missense_Mutation_p.R744C	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	755					apoptosis|axon guidance|regulation of apoptosis	integral to membrane		p.R755C(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						CCACAACCTGCGCCTCTCCCT	0.617000													3	24					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1074184	1074184	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:1074184A>G	ENST00000313093.2	+	7	1103	c.872A>G	c.(871-873)aAc>aGc	p.N291S	HMHA1_ENST00000590214.1_Missense_Mutation_p.N318S|HMHA1_ENST00000536472.1_Missense_Mutation_p.N131S|HMHA1_ENST00000539243.2_Missense_Mutation_p.N307S|HMHA1_ENST00000543365.1_Missense_Mutation_p.N174S|HMHA1_ENST00000586866.1_Missense_Mutation_p.N295S	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	291					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TATGCCAAGAACATGGCCAAG	0.652000													30	22					0	0	1	0	0
ZBTB17	7709	broad.mit.edu	37	1	16272237	16272237	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16272237C>T	ENST00000375733.2	-	6	872	c.634G>A	c.(634-636)Gcc>Acc	p.A212T	ZBTB17_ENST00000375743.4_Missense_Mutation_p.A212T|ZBTB17_ENST00000537142.1_Missense_Mutation_p.A130T|ZBTB17_ENST00000448462.2_Missense_Mutation_p.A149T			Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	212					negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)	15		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		GACAAAGCGGCCTCAGCTTCT	0.682000													19	31					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18743465	18743465	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:18743465G>A	ENST00000513874.1	-	3	372	c.233C>T	c.(232-234)gCg>gTg	p.A78V	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	78	Ig-like 1.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						ACCCTCGGGCGCGGTGACCGG	0.617000											OREG0020822	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	32					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138584445	138584445	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:138584445G>A	ENST00000251691.4	+	12	1991	c.1825G>A	c.(1825-1827)Gat>Aat	p.D609N		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	609	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GACAGAGTTTGATTCCTGTGA	0.478000													79	96					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886434	3886434	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:3886434G>A	ENST00000319331.3	+	2	870	c.109G>A	c.(109-111)Gta>Ata	p.V37I	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	37	LRRNT.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		ACAACTTTGCGTATGTGAAAT	0.453000													16	38					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12704240	12704240	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:12704240C>A	ENST00000380682.1	+	7	1104	c.598C>A	c.(598-600)Ctt>Att	p.L200I		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	200					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CAACTCACTTCTTTTTATGCC	0.363000													24	6					2.48779e-11	2.67617e-11	1	1	0
MYH13	8735	broad.mit.edu	37	17	10231371	10231371	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:10231371T>A	ENST00000418404.3	-	21	2666	c.2503A>T	c.(2503-2505)Aac>Tac	p.N835Y	MYH13_ENST00000570743.1_Missense_Mutation_p.N835Y|MYH13_ENST00000252172.4_Missense_Mutation_p.N835Y|RP11-401O9.3_ENST00000577743.1_RNA			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	835					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						AAGAACAGGTTCATCCAGGGC	0.483000											OREG0024177	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	37					0	0	1	0	0
XRRA1	143570	broad.mit.edu	37	11	74554403	74554403	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:74554403G>A	ENST00000340360.6	-	19	2552	c.2221C>T	c.(2221-2223)Cgg>Tgg	p.R741W	XRRA1_ENST00000527087.1_3'UTR|XRRA1_ENST00000321448.8_Missense_Mutation_p.R466W	NM_182969.2	NP_892014.1	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	741					response to X-ray	cytoplasm|nucleus				breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(3)	20						ACCAGCTGCCGGTAACGTGCC	0.627000													6	5					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75981969	75981969	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75981969G>A	ENST00000308508.5	-	3	1529	c.1437C>T	c.(1435-1437)ggC>ggT	p.G479G		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	479	Globular or compact configuration stabilized by disulfide bonds.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GCTCGAGCTCGCCATGGCGTG	0.637000													31	37					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64678617	64678617	+	Silent	SNP	C	C	T	rs151243555		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64678617C>T	ENST00000421419.2	-	10	1473	c.1359G>A	c.(1357-1359)acG>acA	p.T453T	ATG2A_ENST00000377264.3_Silent_p.T453T			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	453							protein binding	p.T453T(1)		breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						TGAAAAAGTGCGTGGCGAGGT	0.607000													10	12					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53445691	53445691	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53445691C>A	ENST00000314250.6	+	2	418	c.128C>A	c.(127-129)cCt>cAt	p.P43H	TENC1_ENST00000451358.1_Missense_Mutation_p.P43H|RP11-983P16.4_ENST00000550601.1_RNA|RP11-983P16.4_ENST00000546793.1_RNA|TENC1_ENST00000546602.1_Missense_Mutation_p.P43H|TENC1_ENST00000549700.1_Missense_Mutation_p.P43H|TENC1_ENST00000552570.1_Missense_Mutation_p.P43H|TENC1_ENST00000379902.3_5'UTR|TENC1_ENST00000314276.3_Missense_Mutation_p.P53H	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	43					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						CGGAAGAAACCTCCAGTCTGT	0.557000													26	34					2.61193e-14	2.84738e-14	1	1	0
ANP32D	23519	broad.mit.edu	37	12	48866542	48866542	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48866542G>A	ENST00000266594.1	+	1	95	c.95G>A	c.(94-96)gGc>gAc	p.G32D		NM_012404.2	NP_036536.2	O95626	AN32D_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member D	32										central_nervous_system(1)|large_intestine(2)|lung(3)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	9						TCAAATGAAGGCAAATTGGAA	0.413000													52	88					0	0	1	0	0
CMPK2	129607	broad.mit.edu	37	2	7003601	7003601	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:7003601C>T	ENST00000256722.5	-	2	783	c.784G>A	c.(784-786)Gcc>Acc	p.A262T	CMPK2_ENST00000404168.1_Missense_Mutation_p.A262T|CMPK2_ENST00000478738.1_5'UTR|CMPK2_ENST00000458098.1_Missense_Mutation_p.A262T	NM_207315.3	NP_997198.2	Q5EBM0	CMPK2_HUMAN	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	262					dTDP biosynthetic process	mitochondrion	ATP binding|cytidylate kinase activity|thymidylate kinase activity|UMP kinase activity			large_intestine(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TTACCCGTGGCATCCAGTCCT	0.433000													23	42					0	0	1	0	0
MANSC1	54682	broad.mit.edu	37	12	12483540	12483540	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:12483540C>T	ENST00000535902.1	-	4	1280	c.717G>A	c.(715-717)tcG>tcA	p.S239S	MANSC1_ENST00000396349.3_Silent_p.S205S|MANSC1_ENST00000545735.1_Silent_p.S158S			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	239	Thr-rich.					integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		TTGGAGTAGCCGAGGTGGTAT	0.542000													11	38					0	0	1	0	0
BBOX1	8424	broad.mit.edu	37	11	27076939	27076939	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:27076939G>A	ENST00000263182.3	+	3	330		c.e3-1		BBOX1_ENST00000527505.1_3'UTR|BBOX1_ENST00000525090.1_5'UTR|BBOX1_ENST00000529202.1_Intron|RP11-1L12.3_ENST00000526061.1_RNA|BBOX1_ENST00000528583.1_Splice_Site	NM_003986.2	NP_003977.1	O75936	BODG_HUMAN	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1						carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	23					Succinic acid(DB00139)|Vitamin C(DB00126)	ATTTGTCATAGCAGGTAGCTG	0.468000													9	14					0	0	1	0	0
KCNV2	169522	broad.mit.edu	37	9	2718278	2718278	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:2718278G>A	ENST00000382082.3	+	1	777	c.539G>A	c.(538-540)cGc>cAc	p.R180H		NM_133497.3	NP_598004.1	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	180						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	35				GBM - Glioblastoma multiforme(50;0.0257)		TGTCCGCGCCGCTTCCTGGAG	0.657000													3	4					0	0	1	0	0
ABI2	10152	broad.mit.edu	37	2	204259440	204259440	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:204259440G>A	ENST00000295851.4	+	6	892	c.596G>A	c.(595-597)cGc>cAc	p.R199H	ABI2_ENST00000261016.6_Missense_Mutation_p.R148H|ABI2_ENST00000261018.7_Intron|ABI2_ENST00000424558.1_Missense_Mutation_p.R193H|ABI2_ENST00000430574.1_3'UTR|ABI2_ENST00000422511.2_Missense_Mutation_p.R199H|ABI2_ENST00000430418.1_Intron|ABI2_ENST00000261017.5_Missense_Mutation_p.R193H|RAPH1_ENST00000457812.1_3'UTR			Q9NYB9	ABI2_HUMAN	abl-interactor 2	199	Pro-rich.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding			breast(1)|kidney(3)|large_intestine(1)|liver(2)|lung(4)|prostate(2)|skin(1)|urinary_tract(1)	15						TCCCCCTATCGCACACTGGAG	0.498000													4	64					0	0	1	0	0
NUPL1	9818	broad.mit.edu	37	13	25881944	25881944	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:25881944C>A	ENST00000463407.1	+	2	251	c.107_splice	c.e2-1	p.S36_splice	NUPL1_ENST00000381736.3_Splice_Site_p.S36_splice|NUPL1_ENST00000381718.3_Splice_Site_p.S36_splice|NUPL1_ENST00000466694.1_3'UTR			Q9BVL2	NUPL1_HUMAN	nucleoporin like 1	36	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore				breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|stomach(1)|urinary_tract(1)	16		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		TTTAAATAAGCAACCCTTCTG	0.363000													29	38					7.11191e-15	7.77369e-15	1	1	0
ST18	9705	broad.mit.edu	37	8	53084572	53084572	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:53084572G>A	ENST00000276480.7	-	10	1532	c.849C>T	c.(847-849)agC>agT	p.S283S		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	283						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCAGGCTCTCGCTATCTTCCT	0.537000													22	37					0	0	1	0	0
TSFM	10102	broad.mit.edu	37	12	58190056	58190056	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:58190056G>A	ENST00000454289.3	+	6	881	c.668G>A	c.(667-669)aGt>aAt	p.S223N	TSFM_ENST00000548851.1_Intron|TSFM_ENST00000550559.1_Intron|TSFM_ENST00000350762.5_Missense_Mutation_p.S183N|TSFM_ENST00000497617.1_3'UTR|TSFM_ENST00000543727.1_Intron|TSFM_ENST00000540550.1_3'UTR|TSFM_ENST00000323833.8_Missense_Mutation_p.S244N	NM_005726.5	NP_005717.3	P43897	EFTS_HUMAN	Ts translation elongation factor, mitochondrial	223					regulation of transcription elongation, DNA-dependent	mitochondrion|nucleus	translation elongation factor activity			endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)	8	all_cancers(7;6.31e-80)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					GCAATGCAGAGTCCCTCACTT	0.512000													4	11					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53420780	53420780	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:53420780G>A	ENST00000377942.3	-	1	1995	c.1792C>T	c.(1792-1794)Cgc>Tgc	p.R598C	PCDH8_ENST00000338862.4_Missense_Mutation_p.R598C	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	598	Cadherin 5.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TCCAGCACGCGCACTTGCACT	0.657000													9	9					0	0	1	0	0
BUB1B	701	broad.mit.edu	37	15	40462754	40462754	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40462754G>T	ENST00000287598.6	+	4	451	c.256G>T	c.(256-258)Gag>Tag	p.E86*	BUB1B_ENST00000412359.3_Nonsense_Mutation_p.E100*|BUB1B_ENST00000560120.1_3'UTR	NM_001211.5	NP_001202.4	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	86	BUB1 N-terminal.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		CAGCTGGACAGAGCAGAACTA	0.373000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				24	43					7.87624e-14	8.57347e-14	1	1	0
ARID4B	51742	broad.mit.edu	37	1	235345271	235345271	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:235345271G>T	ENST00000264183.3	-	20	3460	c.2963C>A	c.(2962-2964)cCt>cAt	p.P988H	ARID4B_ENST00000366603.2_Missense_Mutation_p.P988H|ARID4B_ENST00000349213.3_Missense_Mutation_p.P902H	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	988					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			ATTGACTGGAGGTGGTTTTTC	0.473000													19	122					3.62473e-10	3.8659e-10	1	1	0
SLC9A6	10479	broad.mit.edu	37	X	135067782	135067782	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:135067782G>T	ENST00000370695.4	+	1	156	c.121G>T	c.(121-123)Ggg>Tgg	p.G41W	SLC9A6_ENST00000370698.3_Missense_Mutation_p.G41W|SLC9A6_ENST00000370701.1_5'UTR	NM_001042537.1	NP_001036002.1	Q92581	SL9A6_HUMAN	solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	41					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					TGACTGGGCAGGGGCTTCGGA	0.701000													22	5					3.01185e-09	3.19065e-09	1	1	0
MYRF	745	broad.mit.edu	37	11	61544762	61544762	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61544762C>T	ENST00000278836.5	+	12	1713	c.1617C>T	c.(1615-1617)agC>agT	p.S539S	TMEM258_ENST00000535042.1_Intron|MYRF_ENST00000265460.5_Silent_p.S530S|MYRF_ENST00000327797.1_Silent_p.S164S	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		AGTTCGAGAGCGACAGCGATG	0.672000													14	23					0	0	1	0	0
EIF3F	8665	broad.mit.edu	37	11	8013378	8013378	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:8013378C>T	ENST00000533626.1	+	4	1041	c.415C>T	c.(415-417)Cac>Tac	p.H139Y	EIF3F_ENST00000537635.1_Missense_Mutation_p.H154Y|EIF3F_ENST00000449102.2_Intron|EIF3F_ENST00000309828.4_Missense_Mutation_p.H139Y			O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3, subunit F	139	MPN.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)	13				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTCAGTGCCGCACAATGAGTC	0.498000													23	60					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53337810	53337810	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:53337810C>T	ENST00000566029.1	+	31	6101	c.5892C>T	c.(5890-5892)ggC>ggT	p.G1964G	CHD9_ENST00000398510.3_Silent_p.G1964G|CHD9_ENST00000564845.1_Silent_p.G1964G|CHD9_ENST00000447540.1_Silent_p.G1964G			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1964					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				GGGAATGTGGCCCTCATGATA	0.483000													22	31					0	0	1	0	0
ZNF319	0	broad.mit.edu	37	16	58030521	58030521	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:58030521C>T	ENST00000299237.2	-	2	2271	c.1649G>A	c.(1648-1650)cGc>cAc	p.R550H		NM_020807.1	NP_065858.1	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	550					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8						GTCTAGGAAGCGCTCCCCGCA	0.672000													11	15					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38407051	38407051	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:38407051C>A	ENST00000322350.5	+	8	1296	c.950C>A	c.(949-951)cCt>cAt	p.P317H	EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000336740.6_Missense_Mutation_p.P83H|EGFLAM_ENST00000354891.3_Missense_Mutation_p.P317H	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	317						cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GCATCTCTCCCTGTGACCACG	0.473000													23	50					1.10923e-09	1.18008e-09	1	1	0
SCARB1	949	broad.mit.edu	37	12	125267257	125267257	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:125267257C>T	ENST00000261693.6	-	12	1628	c.1502G>A	c.(1501-1503)gGc>gAc	p.G501D	SCARB1_ENST00000546215.1_Missense_Mutation_p.G473D|SCARB1_ENST00000535005.1_5'UTR|SCARB1_ENST00000415380.2_Intron|SCARB1_ENST00000376788.1_Missense_Mutation_p.G401D|SCARB1_ENST00000339570.5_Intron	NM_005505.4	NP_005496.4	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1	0					adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|prostate(1)	17	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	CAGCACAGAGCCCTTGGGAGC	0.498000													17	28					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	90049658	90049658	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:90049658G>A	ENST00000428670.3	-	2	462	c.6C>T	c.(4-6)ggC>ggT	p.G2G	ATP2B1_ENST00000261173.2_Silent_p.G2G|ATP2B1_ENST00000359142.3_Silent_p.G2G|ATP2B1_ENST00000348959.3_Silent_p.G2G			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	2					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding	p.G2G(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						TTGCCATGTCGCCCATTACAA	0.358000													20	26					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158813813	158813813	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158813813G>A	ENST00000368141.4	+	4	732	c.471G>A	c.(469-471)aaG>aaA	p.K157K		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	157					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					AGCAGAGTAAGCCCCCAGGTC	0.468000													27	50					0	0	1	0	0
ZDHHC5	25921	broad.mit.edu	37	11	57466485	57466485	+	Missense_Mutation	SNP	G	G	A	rs145781238		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57466485G>A	ENST00000287169.3	+	11	2939	c.1577G>A	c.(1576-1578)cGa>cAa	p.R526Q	ZDHHC5_ENST00000527985.1_Missense_Mutation_p.R473Q	NM_015457.2	NP_056272.2	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC-type containing 5	526						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(6)|kidney(3)|large_intestine(3)|lung(5)|skin(1)	18						CCAACACACCGAGAGCCCTCA	0.617000													19	33					0	0	1	0	0
ZNF675	171392	broad.mit.edu	37	19	23836705	23836705	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:23836705C>T	ENST00000359788.4	-	4	1198	c.1030G>A	c.(1030-1032)Gaa>Aaa	p.E344K	ZNF675_ENST00000601935.1_Intron|ZNF675_ENST00000596211.1_Intron|ZNF675_ENST00000600313.1_Intron	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	344					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTTCCACATTCTTCACATTTG	0.388000													17	49					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121528227	121528227	+	Missense_Mutation	SNP	G	G	A	rs143250160		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:121528227G>A	ENST00000305949.1	+	18	2087	c.2042G>A	c.(2041-2043)cGt>cAt	p.R681H		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	681	Interaction with MDM2 (By similarity).				cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			CTTCAGTCTCGTCTTATTCGT	0.403000													33	53					0	0	1	0	0
SKIDA1	387640	broad.mit.edu	37	10	21804455	21804455	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:21804455G>A	ENST00000449193.2	-	4	4549	c.2297C>T	c.(2296-2298)cCt>cTt	p.P766L	SKIDA1_ENST00000444772.3_Missense_Mutation_p.P687L	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1																		CCCATCCTCAGGTTTTGGAGA	0.463000													52	70					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120189920	120189920	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:120189920G>A	ENST00000392521.2	-	23	2894	c.2839C>T	c.(2839-2841)Cgc>Tgc	p.R947C	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.R905C	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	905					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TTCGCCTGGCGAAGCTGGCTC	0.607000													9	23					0	0	1	0	0
CATSPER3	347732	broad.mit.edu	37	5	134332150	134332150	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:134332150G>A	ENST00000282611.6	+	3	526	c.440G>A	c.(439-441)gGc>gAc	p.G147D		NM_178019.2	NP_821138.1	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	147					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATCGCTGATGGCATGCAGTCC	0.547000													16	30					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178413417	178413417	+	Missense_Mutation	SNP	G	G	A	rs61733044	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:178413417G>A	ENST00000231188.5	-	8	2016	c.1838C>T	c.(1837-1839)aCg>aTg	p.T613M	GRM6_ENST00000517717.1_Missense_Mutation_p.T613M|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	613					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GACGATGGGCGTGTTGTTGTA	0.672000													8	15					0	0	1	0	0
VDR	0	broad.mit.edu	37	12	48258928	48258928	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48258928C>T	ENST00000229022.3	-	5	460	c.179G>A	c.(178-180)tGc>tAc	p.C60Y	VDR_ENST00000535672.1_Missense_Mutation_p.C28Y|VDR_ENST00000395324.2_Missense_Mutation_p.C60Y|VDR_ENST00000549336.1_Missense_Mutation_p.C60Y|VDR_ENST00000550325.1_Missense_Mutation_p.C110Y	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	60					decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GTTGAAGGGGCAGGTGAATAG	0.612000													19	47					0	0	1	0	0
CDK1	983	broad.mit.edu	37	10	62544621	62544621	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:62544621T>C	ENST00000448257.2	+	3	395		c.e3+2		CDK1_ENST00000316629.4_Splice_Site|CDK1_ENST00000395284.3_Splice_Site|CDK1_ENST00000373809.2_Splice_Site			P06493	CDK1_HUMAN	cyclin-dependent kinase 1						activation of MAPK activity|activation of MAPKK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|axon guidance|cell division|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|mitosis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein localization to kinetochore|Ras protein signal transduction|regulation of transcription involved in G1/S phase of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|midbody|nucleoplasm|spindle microtubule	ATP binding|cyclin-dependent protein kinase activity|RNA polymerase II carboxy-terminal domain kinase activity			ovary(1)	1						TATAGTCAGGTATGTTGTAAT	0.338000													21	33					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53680240	53680240	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53680240C>T	ENST00000257934.4	+	18	3811	c.3720C>T	c.(3718-3720)aaC>aaT	p.N1240N	ESPL1_ENST00000552462.1_Silent_p.N1240N	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1240					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						AGCCATCAAACGAGAGCCTGC	0.552000													35	54					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70031740	70031740	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:70031740A>G	ENST00000355303.5	+	25	2938	c.2633A>G	c.(2632-2634)gAc>gGc	p.D878G	ANO1_ENST00000398543.2_Missense_Mutation_p.D732G|ANO1_ENST00000530676.1_Missense_Mutation_p.D732G|ANO1_ENST00000525494.1_3'UTR|ANO1_ENST00000531349.1_Missense_Mutation_p.D587G|ANO1_ENST00000538023.1_Missense_Mutation_p.D878G	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	878					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						AACAAGTACGACATCTCCAAG	0.592000													6	31					0	0	1	0	0
PGM5	5239	broad.mit.edu	37	9	71002484	71002484	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:71002484G>A	ENST00000396396.1	+	4	906	c.677G>A	c.(676-678)cGc>cAc	p.R226H	PGM5_ENST00000396392.1_Missense_Mutation_p.R226H|PGM5_ENST00000604870.2_3'UTR	NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	226					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						CTGAAGATTCGCATTGACGCA	0.468000													18	28					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160395031	160395031	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160395031G>A	ENST00000368061.2	+	8	1903	c.1429G>A	c.(1429-1431)Gtt>Att	p.V477I		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	477					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGATGGCATCGTTTTCCTCTT	0.542000													19	24					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61844449	61844449	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:61844449G>A	ENST00000280772.1	-	32	4176	c.3985C>T	c.(3985-3987)Cga>Tga	p.R1329*	ANK3_ENST00000373827.2_Nonsense_Mutation_p.R1323*|ANK3_ENST00000503366.1_Nonsense_Mutation_p.R1330*|ANK3_ENST00000355288.2_Nonsense_Mutation_p.R463*	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1329					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding	p.R463*(1)|p.R964*(1)|p.R1329*(1)		NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CAGAAACATCGCAAGGAAGAT	0.403000													60	73					0	0	1	0	0
IL24	11009	broad.mit.edu	37	1	207073659	207073659	+	Missense_Mutation	SNP	C	C	T	rs144126009		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:207073659C>T	ENST00000367093.3	+	4	537	c.263C>T	c.(262-264)aCg>aTg	p.T88M	IL24_ENST00000294984.2_Missense_Mutation_p.T87M|IL24_ENST00000491169.1_3'UTR|IL24_ENST00000391929.3_Missense_Mutation_p.T88M	NM_001185157.1|NM_001185158.1	NP_001172086.1|NP_001172087.1	Q13007	IL24_HUMAN	interleukin 24	87					apoptosis	extracellular space	cytokine activity			endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12	Breast(84;0.201)					GATAACATCACGAGTGCCCGG	0.542000													24	39					0	0	1	0	0
PDIA3	2923	broad.mit.edu	37	15	44063404	44063404	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:44063404G>T	ENST00000300289.5	+	13	1654	c.1506G>T	c.(1504-1506)caG>caT	p.Q502H	PDIA3_ENST00000538521.1_Missense_Mutation_p.Q482H	NM_005313.4	NP_005304.3	P30101	PDIA3_HUMAN	protein disulfide isomerase family A, member 3	502					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(2)|skin(1)	17		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		AGAAGGCACAGGAGGATCTCT	0.423000													26	33					2.12542e-12	2.29988e-12	1	1	0
TNFRSF1A	7132	broad.mit.edu	37	12	6438599	6438599	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6438599G>A	ENST00000162749.2	-	10	1546	c.1247C>T	c.(1246-1248)gCc>gTc	p.A416V	TNFRSF1A_ENST00000540022.1_Missense_Mutation_p.A373V	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	416	Death.				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						CTCCAGCGTGGCCTCGCGCCG	0.731000													4	6					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8115637	8115637	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:8115637C>T	ENST00000305253.4	+	5	704	c.463C>T	c.(463-465)Cgc>Tgc	p.R155C	TUB_ENST00000299506.2_Missense_Mutation_p.R100C|TUB_ENST00000534099.1_Missense_Mutation_p.R106C	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	100					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		GGGAGCCACGCGCCCAACAGC	0.607000													5	15					0	0	1	0	0
DCST1	149095	broad.mit.edu	37	1	155014322	155014322	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155014322G>A	ENST00000295542.1	+	8	977	c.881G>A	c.(880-882)gGc>gAc	p.G294D	DCST1_ENST00000423025.2_Missense_Mutation_p.G269D|DCST1_ENST00000392480.1_Missense_Mutation_p.G294D|DCST1_ENST00000368419.2_Missense_Mutation_p.G294D	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	294						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TTCTTCTGTGGCATTGCCAAG	0.562000													29	32					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134670843	134670843	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:134670843C>T	ENST00000398015.3	+	3	1124	c.754C>T	c.(754-756)Cga>Tga	p.R252*	EPHB1_ENST00000488154.1_Intron	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	252	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						GCCTATTGGGCGATGCACCTG	0.582000													15	86					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41583417	41583417	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:41583417G>A	ENST00000396942.1	-	6	557	c.474C>T	c.(472-474)aaC>aaT	p.N158N	ANK1_ENST00000347528.4_Silent_p.N158N|ANK1_ENST00000289734.7_Silent_p.N158N|ANK1_ENST00000265709.8_Silent_p.N191N|ANK1_ENST00000396945.1_Silent_p.N158N|ANK1_ENST00000352337.4_Silent_p.N158N|ANK1_ENST00000379758.2_Silent_p.N158N			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	158	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GCGCGACGACGTTCTCATGGC	0.672000													8	20					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21143947	21143947	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:21143947G>A	ENST00000602326.1	-	32	4886	c.4303C>T	c.(4303-4305)Cga>Tga	p.R1435*	EIF4G3_ENST00000537738.1_Nonsense_Mutation_p.R919*|EIF4G3_ENST00000536266.1_Nonsense_Mutation_p.R1033*|EIF4G3_ENST00000374935.3_Nonsense_Mutation_p.R1149*|EIF4G3_ENST00000400422.1_Nonsense_Mutation_p.R1429*|EIF4G3_ENST00000374937.3_Nonsense_Mutation_p.R1435*|EIF4G3_ENST00000264211.8_Nonsense_Mutation_p.R1429*	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	1429	EIF4A-binding (By similarity).|W2.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TTCTCGAGTCGCTTATACAGC	0.423000													38	55					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42144707	42144707	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:42144707G>A	ENST00000379310.3	-	44	5574	c.5506C>T	c.(5506-5508)Cga>Tga	p.R1836*		NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		ATTCCATATCGTGACAGATTT	0.408000													4	123					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75975362	75975362	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75975362C>T	ENST00000308508.5	-	6	4562	c.4470G>A	c.(4468-4470)gcG>gcA	p.A1490A		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1490	Gly/Ser-rich (glycosaminoglycan attachment domain).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						CAGGGATGGGCGCAGTGGCCC	0.677000													5	9					0	0	1	0	0
WDHD1	11169	broad.mit.edu	37	14	55493428	55493428	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:55493428C>T	ENST00000360586.3	-	2	143		c.e2+1		WDHD1_ENST00000421192.1_Splice_Site|WDHD1_ENST00000420358.2_Intron	NM_007086.3	NP_009017.1	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1							cytoplasm|nucleoplasm	DNA binding	p.?(1)		breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(2)	42						AAGAACCTTACCTCCCAGAAT	0.403000													10	42					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36714303	36714303	+	Silent	SNP	C	C	T	rs143316848	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36714303C>T	ENST00000216181.5	-	11	1406	c.1176G>A	c.(1174-1176)ccG>ccA	p.P392P		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	392	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CCTTGATGCGCGGGGTGAGGA	0.537000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				6	165					0	0	1	0	0
ACO1	48	broad.mit.edu	37	9	32440537	32440537	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:32440537C>T	ENST00000379923.1	+	20	2528	c.2322C>T	c.(2320-2322)taC>taT	p.Y774Y	ACO1_ENST00000309951.5_Silent_p.Y774Y|ACO1_ENST00000541043.1_Silent_p.Y675Y	NM_001278352.1	NP_001265281.1	P21399	ACOC_HUMAN	aconitase 1, soluble	774					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding			breast(1)|endometrium(7)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	30			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		GCAAAGAGTACGGTGCAGGCA	0.562000													14	28					0	0	1	0	0
TOE1	114034	broad.mit.edu	37	1	45806886	45806886	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:45806886C>T	ENST00000372090.5	+	2	777	c.195_splice	c.e2+1	p.T65_splice	TOE1_ENST00000539779.1_Intron|TOE1_ENST00000495703.1_3'UTR	NM_025077.3	NP_079353.3	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	65						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	11	Acute lymphoblastic leukemia(166;0.155)					GCTGTGGACACGGTGAGAGTT	0.547000													20	32					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38523624	38523624	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:38523624A>G	ENST00000263409.4	-	5	620	c.458T>C	c.(457-459)tTa>tCa	p.L153S	LIFR_ENST00000503088.1_5'UTR|LIFR_ENST00000453190.2_Missense_Mutation_p.L153S	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	153					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					CTTTAGGTATAATGTAGAGGT	0.358000			T	PLAG1	salivary adenoma								30	46					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65408562	65408562	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65408562C>T	ENST00000394224.3	+	2	466	c.170C>T	c.(169-171)gCa>gTa	p.A57V	SIPA1_ENST00000534313.1_Missense_Mutation_p.A57V|SIPA1_ENST00000394227.3_Missense_Mutation_p.A57V|SIPA1_ENST00000527525.1_Missense_Mutation_p.A57V	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	57					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						GGCAGCGATGCAGGCGAGGCC	0.726000													9	8					0	0	1	0	0
HSF4	3299	broad.mit.edu	37	16	67199676	67199676	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67199676G>A	ENST00000264009.8	+	5	1252	c.287G>A	c.(286-288)cGc>cAc	p.R96H	RP11-5A19.5_ENST00000580114.1_3'UTR|HSF4_ENST00000521374.1_Missense_Mutation_p.R96H|RP11-5A19.5_ENST00000518753.1_3'UTR|HSF4_ENST00000421453.1_Missense_Mutation_p.R96H|HSF4_ENST00000584272.1_Missense_Mutation_p.R96H	NM_001040667.2	NP_001035757.1	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4	96					response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		AGGCCGGAGCGCGACCACGTC	0.716000													4	16					0	0	1	0	0
TRIB2	28951	broad.mit.edu	37	2	12880827	12880827	+	Silent	SNP	C	C	T	rs150722548	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:12880827C>T	ENST00000155926.4	+	3	2358	c.939C>T	c.(937-939)agC>agT	p.S313S	TRIB2_ENST00000381465.2_Silent_p.S177S	NM_021643.3	NP_067675.1	Q92519	TRIB2_HUMAN	tribbles pseudokinase 2	313					negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(5)|prostate(1)|skin(1)|stomach(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CAGATTTTAGCGTCTCGAATT	0.517000													10	21					0	0	1	0	0
TBC1D23	55773	broad.mit.edu	37	3	100002532	100002532	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:100002532G>A	ENST00000394144.4	+	4	360	c.353G>A	c.(352-354)cGt>cAt	p.R118H	TBC1D23_ENST00000486274.1_3'UTR|TBC1D23_ENST00000475134.1_Intron|TBC1D23_ENST00000344949.5_Missense_Mutation_p.R118H	NM_001199198.2	NP_001186127.1	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	118	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(10)|ovary(1)|prostate(2)|skin(2)	25						TGTAAATCACGTAACATTAAA	0.368000													20	31					0	0	1	0	0
NOA1	84273	broad.mit.edu	37	4	57843409	57843409	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:57843409G>A	ENST00000264230.4	-	1	1580	c.343C>T	c.(343-345)Caa>Taa	p.Q115*		NM_032313.2	NP_115689.1	Q8NC60	CD014_HUMAN	nitric oxide associated 1	115							GTP binding										CGTAGGTTTtgctgtcgccgc	0.706000													7	4					0	0	1	0	0
SNF8	11267	broad.mit.edu	37	17	47018301	47018301	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:47018301C>T	ENST00000502492.1	-	3	611	c.229G>A	c.(229-231)Gtg>Atg	p.V77M	SNF8_ENST00000290330.3_Missense_Mutation_p.V77M			Q96H20	SNF8_HUMAN	SNF8, ESCRT-II complex subunit	77					cellular membrane organization|endosome transport|protein transport|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytosol|late endosome membrane|transcription factor complex	transcription factor binding	p.V77M(1)		breast(1)|endometrium(1)|lung(1)	3						AGCGGATCCACGCCAATGGTT	0.507000													27	40					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78265574	78265574	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78265574C>T	ENST00000582970.1	+	8	1562	c.1419C>T	c.(1417-1419)ggC>ggT	p.G473G	RNF213_ENST00000319921.4_Silent_p.G473G|RNF213_ENST00000456466.1_Silent_p.G473G|RNF213_ENST00000508628.2_Silent_p.G522G	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	473										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AGAAGAAGGGCGAGTACGTCA	0.473000													31	43					0	0	1	0	0
GPHN	10243	broad.mit.edu	37	14	67578599	67578599	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:67578599C>T	ENST00000478722.1	+	15	2556	c.1435C>T	c.(1435-1437)Cga>Tga	p.R479*	GPHN_ENST00000315266.5_Nonsense_Mutation_p.R446*|GPHN_ENST00000305960.9_Nonsense_Mutation_p.R415*|GPHN_ENST00000544752.2_3'UTR|GPHN_ENST00000543237.1_Nonsense_Mutation_p.R492*	NM_020806.4	NP_065857.1	Q9NQX3	GEPH_HUMAN	gephyrin	446	MPT adenylyltransferase.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cell junction|cytoplasm|cytoskeleton|postsynaptic membrane	ATP binding|metal ion binding|nucleotidyltransferase activity	p.R479*(3)		large_intestine(8)|liver(1)|ovary(2)|stomach(1)	12		all_cancers(7;0.0476)|all_hematologic(31;0.0116)		Epithelial(1;1.73e-08)|all cancers(60;3.15e-07)|OV - Ovarian serous cystadenocarcinoma(108;0.000275)|BRCA - Breast invasive adenocarcinoma(234;0.00323)|Colorectal(3;0.0938)|KIRC - Kidney renal clear cell carcinoma(182;0.184)		ACTTGAAGTGCGAATTCTGGT	0.383000			T	MLL	AL								23	31					0	0	1	0	0
ARPC1A	10552	broad.mit.edu	37	7	98983333	98983333	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:98983333C>T	ENST00000432884.2	+	12	1403	c.942C>T	c.(940-942)agC>agT	p.S314S	ARPC1B_ENST00000451682.1_5'UTR|ARPC1B_ENST00000252725.5_5'UTR|ARPC1B_ENST00000474880.1_3'UTR			Q92747	ARC1A_HUMAN	actin related protein 2/3 complex, subunit 1A, 41kDa	363					actin cytoskeleton organization|regulation of actin filament polymerization	actin cytoskeleton|cytoplasm	actin binding			endometrium(3)|large_intestine(5)|liver(2)|lung(7)|ovary(1)|prostate(1)	19	all_cancers(62;4.46e-09)|all_epithelial(64;3.44e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0258)		STAD - Stomach adenocarcinoma(171;0.215)			AGGAGCCAAGCCGCCATGGCC	0.642000													3	6					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128451905	128451905	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128451905G>A	ENST00000297788.4	+	13	2447	c.2080G>A	c.(2080-2082)Gcc>Acc	p.A694T	CCDC136_ENST00000464832.1_Intron|CCDC136_ENST00000487361.1_Intron|CCDC136_ENST00000378685.4_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	694						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GATGTATGACGCCGGTCAGGC	0.582000													15	26					0	0	1	0	0
TNKS	8658	broad.mit.edu	37	8	9588532	9588532	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:9588532G>A	ENST00000310430.6	+	14	2160	c.2134G>A	c.(2134-2136)Gcc>Acc	p.A712T	TNKS_ENST00000518281.1_Missense_Mutation_p.A475T	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	712					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		CGATGTCCATGCCAAAGACAA	0.448000													19	27					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160769675	160769675	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160769675C>A	ENST00000263285.5	+	2	287	c.257C>A	c.(256-258)gCt>gAt	p.A86D	LY9_ENST00000341032.4_Missense_Mutation_p.A86D|LY9_ENST00000471816.1_3'UTR|LY9_ENST00000368040.1_5'UTR|LY9_ENST00000368041.2_Missense_Mutation_p.A46D|LY9_ENST00000368039.2_Missense_Mutation_p.A86D	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	86	Ig-like V-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCCAAAAATGCTCTTGCTTTC	0.493000													27	30					1.5548e-18	1.71633e-18	1	1	0
FAM118A	55007	broad.mit.edu	37	22	45726576	45726576	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:45726576G>A	ENST00000216214.3	+	6	1449	c.615G>A	c.(613-615)tcG>tcA	p.S205S	FAM118A_ENST00000441876.2_Silent_p.S205S|FAM118A_ENST00000405548.3_Silent_p.S23S	NM_001104595.1	NP_001098065.1	Q9NWS6	F118A_HUMAN	family with sequence similarity 118, member A	205						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	11		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TGGACCCATCGGGGTATAAAG	0.572000													7	17					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43930688	43930688	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:43930688G>A	ENST00000262726.7	-	30	4366	c.4113C>T	c.(4111-4113)taC>taT	p.Y1371Y	EFCAB6-AS1_ENST00000431327.2_RNA|EFCAB6_ENST00000396231.2_Silent_p.Y1219Y|EFCAB6_ENST00000461800.1_5'UTR	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1371	EF-hand 15.|Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TCTTTAAGTCGTATTTTATAA	0.418000													28	52					0	0	1	0	0
RECQL4	9401	broad.mit.edu	37	8	145737881	145737881	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145737881G>A	ENST00000428558.2	-	18	2990	c.2949C>T	c.(2947-2949)agC>agT	p.S983S	RECQL4_ENST00000532237.1_5'UTR	NM_004260.3	NP_004251.3	O94761	RECQ4_HUMAN	RecQ protein-like 4	983					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			ACTCCACGGAGCTGCTGCCTT	0.647000			"""N, F, S"""			"""osteosarcoma, skin basal and sqamous cell"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Rothmund-Thomson syndrome;RAPADILINO syndrome;Baller-Gerold syndrome				11	26					0	0	1	0	0
PAEP	5047	broad.mit.edu	37	9	138457638	138457638	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:138457638C>T	ENST00000479141.1	+	6	578	c.534C>T	c.(532-534)tgC>tgT	p.C178C	PAEP_ENST00000277508.5_Silent_p.C178C|PAEP_ENST00000371766.2_Silent_p.C178C	NM_002571.2	NP_002562.2	P09466	PAEP_HUMAN	progestagen-associated endometrial protein	178					multicellular organismal development	extracellular region	binding|transporter activity			cervix(1)|endometrium(1)|lung(1)|prostate(1)|skin(1)|stomach(1)	6				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		CAGAGCCGTGCCGTTTCTAGG	0.617000													49	81					0	0	1	0	0
USP22	23326	broad.mit.edu	37	17	20924447	20924447	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:20924447G>A	ENST00000261497.4	-	3	600	c.397C>T	c.(397-399)Cga>Tga	p.R133*	USP22_ENST00000537526.2_Nonsense_Mutation_p.R121*|USP22_ENST00000455117.2_Intron	NM_015276.1	NP_056091.1	Q9UPT9	UBP22_HUMAN	ubiquitin specific peptidase 22	133					cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	15						CAAGCTTTTCGCTGCTCCTCC	0.478000													12	22					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31734102	31734102	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31734102G>A	ENST00000375686.3	-	15	2481	c.2244C>T	c.(2242-2244)atC>atT	p.I748I	VWA7_ENST00000467576.1_5'UTR|VWA7_ENST00000375688.4_Silent_p.I748I	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	748						extracellular region											AGAAGCTGGCGATGCGGAGAC	0.607000													2	2					0	0	1	0	0
CELF3	11189	broad.mit.edu	37	1	151680022	151680022	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:151680022C>T	ENST00000290583.4	-	7	1526	c.733G>A	c.(733-735)Gcc>Acc	p.A245T	CELF3_ENST00000290585.4_Missense_Mutation_p.A245T|CELF3_ENST00000470688.1_5'UTR|RP11-98D18.1_ENST00000457548.1_RNA|CELF3_ENST00000392706.3_Missense_Mutation_p.A62T	NM_001172648.1|NM_007185.4	NP_001166119.1|NP_009116.3	Q5SZQ8	CELF3_HUMAN	CUGBP, Elav-like family member 3	245					nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	21						AGGCCATTGGCATTGATGGCA	0.647000													4	8					0	0	1	0	0
FOXA1	3169	broad.mit.edu	37	14	38061877	38061877	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:38061877G>A	ENST00000250448.2	-	2	173	c.112C>T	c.(112-114)Ctg>Ttg	p.L38L	FOXA1_ENST00000540786.1_Silent_p.L5L|FOXA1_ENST00000545425.2_5'UTR	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	38					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		ATGGAGCCCAGGCCTGAGTTC	0.592000													26	44					0	0	1	0	0
FAM63B	54629	broad.mit.edu	37	15	59146739	59146739	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:59146739G>A	ENST00000559228.1	+	9	1878	c.1796G>A	c.(1795-1797)cGt>cAt	p.R599H	FAM63B_ENST00000450403.2_Missense_Mutation_p.R598H			Q8NBR6	FA63B_HUMAN	family with sequence similarity 63, member B	599										central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						AATAGTGAACGTAAACGGAAG	0.378000													20	32					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63984647	63984647	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:63984647T>C	ENST00000443617.2	-	31	5880	c.5793A>G	c.(5791-5793)gaA>gaG	p.E1931E	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1931					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TTAGAAGCACTTCGGTCCACT	0.353000													19	42					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92935164	92935164	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:92935164C>T	ENST00000544910.1	+	19	1607	c.1387C>T	c.(1387-1389)Cgc>Tgc	p.R463C	CCDC132_ENST00000541136.1_Missense_Mutation_p.R304C|CCDC132_ENST00000535481.1_Missense_Mutation_p.R213C|CCDC132_ENST00000317751.6_Missense_Mutation_p.R224C|CCDC132_ENST00000305866.5_Missense_Mutation_p.R493C	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	493										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			GGAACAGTCTCGCTCCCCATC	0.378000													25	32					0	0	1	0	0
CYP2E1	1571	broad.mit.edu	37	10	135352437	135352437	+	Missense_Mutation	SNP	G	G	A	rs55982231		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:135352437G>A	ENST00000463117.2	+	11	1723	c.1451G>A	c.(1450-1452)cGt>cAt	p.R484H	SPRN_ENST00000541506.1_Intron|CYP2E1_ENST00000252945.3_Missense_Mutation_p.R484H			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	484					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	ATCCCACCACGTTACAAACTC	0.458000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				24	41					0	0	1	0	0
MFNG	4242	broad.mit.edu	37	22	37876261	37876261	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37876261G>A	ENST00000356998.3	-	3	604	c.381C>T	c.(379-381)ttC>ttT	p.F127F	MFNG_ENST00000416983.3_Silent_p.F113F	NM_002405.3	NP_002396.2	O00587	MFNG_HUMAN	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	127					pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	p.F127F(1)		large_intestine(2)|lung(2)|skin(1)	5	Melanoma(58;0.0574)					AGAAGGTGTCGAACTCAGCAG	0.597000													8	17					0	0	1	0	0
HR	55806	broad.mit.edu	37	8	21978589	21978589	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:21978589C>T	ENST00000381418.4	-	10	3836	c.2356G>A	c.(2356-2358)Gcc>Acc	p.A786T	HR_ENST00000312841.8_Missense_Mutation_p.A786T	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	786							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CTGGGCAGGGCCGGAGTGACG	0.662000													12	31					0	0	1	0	0
ARID3C	138715	broad.mit.edu	37	9	34622047	34622047	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:34622047C>T	ENST00000378909.2	-	6	1200	c.1108G>A	c.(1108-1110)Gcc>Acc	p.A370T		NM_001017363.1	NP_001017363.1	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT-like)	370	Pro-rich.|REKLES.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	14	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		ATCTCTAGGGCCATGTTGATA	0.537000													33	41					0	0	1	0	0
TSPAN9	10867	broad.mit.edu	37	12	3387724	3387724	+	Silent	SNP	G	G	A	rs147946820		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:3387724G>A	ENST00000011898.5	+	4	362	c.201G>A	c.(199-201)acG>acA	p.T67T	TSPAN9_ENST00000407263.1_Silent_p.T67T|TSPAN9_ENST00000537971.1_Silent_p.T67T|TSPAN9_ENST00000492305.1_3'UTR	NM_006675.4	NP_006666.1	O75954	TSN9_HUMAN	tetraspanin 9	67						integral to plasma membrane|membrane fraction				endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			TCATGGTGACGGGCTTCCTCG	0.572000													20	33					0	0	1	0	0
SLC35F2	54733	broad.mit.edu	37	11	107677515	107677515	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:107677515C>T	ENST00000525071.1	-	7	1090	c.502G>A	c.(502-504)Gtg>Atg	p.V168M	SLC35F2_ENST00000375682.4_Missense_Mutation_p.V121M|SLC35F2_ENST00000525815.1_Missense_Mutation_p.V168M|SLC35F2_ENST00000429869.1_Missense_Mutation_p.V168M|SLC35F2_ENST00000265836.7_Missense_Mutation_p.V20M			Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	168					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		CAGACAGCCACGGCGATGAAG	0.478000													19	26					0	0	1	0	0
GOLGA2B	0	broad.mit.edu	37	12	100552543	100552543	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:100552543C>T	ENST00000397112.4	-	0	1600					NR_036632.1															large_intestine(1)|lung(3)	4						CCTCCTGGGGCTCTCTCCTCT	0.547000													4	10					0	0	1	0	0
KCNAB1	7881	broad.mit.edu	37	3	155861202	155861202	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:155861202G>A	ENST00000471742.1	+	1	452	c.235G>A	c.(235-237)Gca>Aca	p.A79T	KCNAB1_ENST00000490337.1_Intron|KCNAB1_ENST00000389636.5_Intron	NM_003471.3	NP_003462.2	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	90						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GACGGGCATGGCATACAGGTA	0.453000													15	86					0	0	1	0	0
PRSS12	8492	broad.mit.edu	37	4	119204124	119204124	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:119204124C>A	ENST00000296498.3	-	12	2464	c.2182G>T	c.(2182-2184)Gcc>Tcc	p.A728S	PRSS12_ENST00000510903.1_5'UTR	NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	728	Peptidase S1.					membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						CTAACCAGGGCTATGTCATAA	0.468000													57	83					1.67886e-27	1.87797e-27	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168103287	168103287	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:168103287G>A	ENST00000409195.1	+	9	5474	c.5385G>A	c.(5383-5385)agG>agA	p.R1795R	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Silent_p.R1795R|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Silent_p.R1573R|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1620					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TGAAGAAAAGGCAGTCTCTGG	0.403000													35	60					0	0	1	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925797	67925797	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67925797G>A	ENST00000304363.4	-	11	2369	c.2016C>T	c.(2014-2016)ccC>ccT	p.P672P		NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	672					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding	p.P672P(1)		NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						AACAACCGACGGGTGAAGGAG	0.493000													12	16					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31157220	31157220	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:31157220C>T	ENST00000268281.4	-	6	668	c.610G>A	c.(610-612)Gcc>Acc	p.A204T	PRSS36_ENST00000569305.1_Missense_Mutation_p.A204T|PRSS36_ENST00000418068.2_Missense_Mutation_p.A204T	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	204	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						TGACAGGTGGCCTCGCCCAGC	0.612000													7	14					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10979978	10979978	+	Missense_Mutation	SNP	C	C	T	rs142712079		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:10979978C>T	ENST00000254488.2	+	14	1855	c.1789C>T	c.(1789-1791)Cgg>Tgg	p.R597W		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	597					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity	p.R597W(1)		breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TCTGAAAATGCGGGGCAAGCT	0.547000													17	45					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100478400	100478400	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:100478400G>A	ENST00000279907.7	-	10	1354	c.1142C>T	c.(1141-1143)gCa>gTa	p.A381V	UHRF1BP1L_ENST00000545232.2_Missense_Mutation_p.A31V|UHRF1BP1L_ENST00000356828.3_Missense_Mutation_p.A381V	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	381										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						TGTTTTGGTTGCATCACTAAA	0.313000													11	48					0	0	1	0	0
DLAT	1737	broad.mit.edu	37	11	111904215	111904215	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:111904215G>T	ENST00000280346.6	+	5	1407	c.748G>T	c.(748-750)Gac>Tac	p.D250Y	DLAT_ENST00000393051.1_Intron|DLAT_ENST00000537636.1_Missense_Mutation_p.D21Y	NM_001931.4	NP_001922.2	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase	250	Lipoyl-binding 2.				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)	22		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	AAGTGAAGGAGACTTACTGGC	0.458000													21	14					1.2644e-06	1.31806e-06	1	1	0
TEX15	56154	broad.mit.edu	37	8	30704683	30704683	+	Silent	SNP	G	G	A	rs150062151	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:30704683G>A	ENST00000256246.2	-	1	1925	c.1851C>T	c.(1849-1851)gaC>gaT	p.D617D		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	617										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TCTGGTGATCGTCATTATTTA	0.378000													17	66					0	0	1	0	0
NARG2	79664	broad.mit.edu	37	15	60740235	60740235	+	Silent	SNP	G	G	A	rs146744595	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:60740235G>A	ENST00000261520.4	-	11	2463	c.2229C>T	c.(2227-2229)ctC>ctT	p.L743L	NARG2_ENST00000439632.1_Silent_p.L606L	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	743						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						TGCAGCGTACGAGTAACAACA	0.388000													30	70					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135893244	135893244	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:135893244G>A	ENST00000264158.8	+	17	1708	c.1665G>A	c.(1663-1665)caG>caA	p.Q555Q	RAB3GAP1_ENST00000487003.1_3'UTR|RAB3GAP1_ENST00000442034.1_Silent_p.Q555Q|RAB3GAP1_ENST00000539493.1_Silent_p.Q511Q	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	555						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		CAGGAGACCAGTTGGTGCCAG	0.418000													15	26					0	0	1	0	0
CHST3	9469	broad.mit.edu	37	10	73767211	73767211	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:73767211C>T	ENST00000373115.4	+	3	859	c.422C>T	c.(421-423)aCg>aTg	p.T141M		NM_004273.4	NP_004264.2	Q7LGC8	CHST3_HUMAN	carbohydrate (chondroitin 6) sulfotransferase 3	141					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity			endometrium(1)|lung(5)	6						ATGGCCACCACGCGCACCGGC	0.667000													6	8					0	0	1	0	0
AGPAT4	56895	broad.mit.edu	37	6	161575257	161575257	+	Missense_Mutation	SNP	G	G	A	rs141441479		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:161575257G>A	ENST00000320285.4	-	4	646	c.434C>T	c.(433-435)tCg>tTg	p.S145L	AGPAT4_ENST00000366911.5_Silent_p.F88F|AGPAT4_ENST00000457520.2_Intron|AGPAT4_ENST00000366906.5_Missense_Mutation_p.S83L|AGPAT4_ENST00000366908.5_3'UTR	NM_020133.2	NP_064518.1	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	145					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding			endometrium(1)|large_intestine(10)|lung(10)|ovary(2)|skin(2)	25		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		CCACTTGCGCGAACAGAAGAC	0.542000													26	27					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115822496	115822496	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:115822496C>T	ENST00000343348.6	-	10	1698	c.911G>A	c.(910-912)cGt>cAt	p.R304H	CTB-118N6.3_ENST00000514214.1_RNA|SEMA6A_ENST00000257414.8_Missense_Mutation_p.R304H|CTB-118N6.3_ENST00000508640.1_RNA|CTB-118N6.3_ENST00000510682.1_RNA|SEMA6A_ENST00000510263.1_Missense_Mutation_p.R304H	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	304	Sema.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CCCGTTGATACGAATCACATC	0.463000													41	53					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3405398	3405398	+	RNA	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3405398T>C	ENST00000529482.1	+	0	171																											ATTCTACAGGTGGTGAAGCTC	0.483000													3	2					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71800950	71800950	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:71800950C>T	ENST00000373545.3	-	32	3886	c.3448G>A	c.(3448-3450)Gca>Aca	p.A1150T	PHKA1_ENST00000373539.3_Missense_Mutation_p.A1209T|PHKA1_ENST00000339490.3_Missense_Mutation_p.A1179T|PHKA1_ENST00000373542.4_Missense_Mutation_p.A1192T|PHKA1_ENST00000541944.1_Missense_Mutation_p.A1120T			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	1192					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CCACTGGGTGCACTGTCATAC	0.532000													8	15					0	0	1	0	0
RP11-115K3.2	0	broad.mit.edu	37	17	36233925	36233925	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36233925G>A	ENST00000590732.1	-	0	114					NR_024178.1																						CACCTCATGGGCCCAGCCTAA	0.338000													8	26					0	0	1	0	0
ATP6V0B	533	broad.mit.edu	37	1	44442475	44442475	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:44442475G>A	ENST00000532642.1	+	6	476	c.379G>A	c.(379-381)Ggc>Agc	p.G127S	ATP6V0B_ENST00000471859.2_Missense_Mutation_p.G174S|ATP6V0B_ENST00000472277.1_3'UTR|ATP6V0B_ENST00000472174.2_Missense_Mutation_p.G127S|ATP6V0B_ENST00000236067.4_Missense_Mutation_p.G80S|ATP6V0B_ENST00000498664.1_Missense_Mutation_p.G80S			Q99437	VATO_HUMAN	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b	127					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transmembrane transporter activity			breast(2)|kidney(1)|large_intestine(3)|lung(3)	9	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				CAAGGCCATCGGCCATCGGAA	0.527000													17	20					0	0	1	0	0
NFKBIZ	64332	broad.mit.edu	37	3	101572708	101572708	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:101572708G>A	ENST00000326172.5	+	5	1452		c.e5+1		NFKBIZ_ENST00000394054.2_Splice_Site|NFKBIZ_ENST00000326151.5_Splice_Site	NM_031419.3	NP_113607.1	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24						ATGGTGACACGTGAGTATTCT	0.378000													14	23					0	0	1	0	0
IKZF4	64375	broad.mit.edu	37	12	56420735	56420735	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56420735C>T	ENST00000262032.5	+	8	824	c.457C>T	c.(457-459)Cgg>Tgg	p.R153W	IKZF4_ENST00000431367.2_Missense_Mutation_p.R51W|IKZF4_ENST00000547791.1_Missense_Mutation_p.R108W|IKZF4_ENST00000548601.1_3'UTR|IKZF4_ENST00000547167.1_Missense_Mutation_p.R153W			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	153					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			TGGGGGCATCCGGCTGCCCAA	0.577000													7	10					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119324195	119324195	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:119324195G>A	ENST00000338891.7	-	9	2400	c.1957C>T	c.(1957-1959)Cgt>Tgt	p.R653C	FAM184A_ENST00000521531.1_Missense_Mutation_p.R653C|RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000352896.5_Missense_Mutation_p.R533C|FAM184A_ENST00000368475.4_Missense_Mutation_p.R533C	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	653										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						AACTCTTCACGAAGTTTAGAA	0.343000													19	35					0	0	1	0	0
PCDHGC3	0	broad.mit.edu	37	5	140856593	140856593	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140856593C>T	ENST00000308177.3	+	1	1014	c.910C>T	c.(910-912)Ctg>Ttg	p.L304L	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000518882.1_Intron	NM_002588.2|NM_032402.1	NP_002579.2|NP_115778.1														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(2)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCGGGATGCTGACAATCAA	0.542000													34	39					0	0	1	0	0
SIGMAR1	10280	broad.mit.edu	37	9	34635742	34635742	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:34635742C>T	ENST00000378892.1	-	3	719	c.292G>A	c.(292-294)Gcc>Acc	p.A98T	SIGMAR1_ENST00000477726.1_Missense_Mutation_p.A156T|SIGMAR1_ENST00000461426.1_5'UTR|SIGMAR1_ENST00000277010.4_Missense_Mutation_p.A187T			Q99720	SGMR1_HUMAN	sigma non-opioid intracellular receptor 1	187					ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding			large_intestine(1)|lung(1)	2					Dextromethorphan(DB00514)	ACAGTGTCGGCCAGCGCGAAG	0.622000													21	17					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105377969	105377969	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:105377969C>T	ENST00000264122.4	-	19	3115	c.2794G>A	c.(2794-2796)Gtc>Atc	p.V932I	CBLB_ENST00000407712.1_Missense_Mutation_p.V147I|CBLB_ENST00000394027.3_Missense_Mutation_p.V910I	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	932	UBA.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						TTTGCATCGACATTTTCCAAT	0.517000			Mis S		AML								37	48					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52391665	52391665	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52391665C>T	ENST00000420323.2	+	23	4155	c.3894C>T	c.(3892-3894)gaC>gaT	p.D1298D		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1298	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GAATGCTGGACAGCCTGCGGG	0.597000													4	8					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94039099	94039099	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:94039099G>A	ENST00000297268.6	+	19	1472	c.1001G>A	c.(1000-1002)gGt>gAt	p.G334D		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	334			G -> C (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGCCCTGTTGGTGCTGCCGGT	0.567000										HNSCC(75;0.22)			10	20					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2060865	2060865	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:2060865G>T	ENST00000382203.1	+	9	1780	c.1571G>T	c.(1570-1572)aGg>aTg	p.R524M	SMARCA2_ENST00000349721.2_Missense_Mutation_p.R524M|SMARCA2_ENST00000382194.1_Missense_Mutation_p.R524M|SMARCA2_ENST00000357248.2_Missense_Mutation_p.R524M			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	524					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		AAGAAAGACAGGCGTTTAGCT	0.443000													16	32					3.32936e-07	3.48341e-07	1	1	0
FAM35A	54537	broad.mit.edu	37	10	88946859	88946859	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:88946859C>T	ENST00000298786.4	+	9	2531	c.2417C>T	c.(2416-2418)gCc>gTc	p.A806V	FAM35A_ENST00000298784.1_Missense_Mutation_p.A737V			Q86V20	FA35A_HUMAN	family with sequence similarity 35, member A	737										endometrium(2)|kidney(2)|large_intestine(5)|lung(1)|ovary(2)|prostate(2)|skin(2)	16						TTAATGACTGCCATTGATGGA	0.363000													11	29					0	0	1	0	0
SH3BP5	9467	broad.mit.edu	37	3	15311378	15311378	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:15311378G>A	ENST00000383791.3	-	4	557	c.337C>T	c.(337-339)Ctg>Ttg	p.L113L	SH3BP5_ENST00000408919.3_5'UTR|SH3BP5_ENST00000253688.5_5'UTR|SH3BP5_ENST00000465894.2_5'UTR|SH3BP5_ENST00000426925.1_5'UTR	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	113					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						TGAGCTTCCAGCTGAGCCTGT	0.567000													30	56					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124404888	124404888	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:124404888A>G	ENST00000303921.2	-	1	793	c.143T>C	c.(142-144)gTg>gCg	p.V48A		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	48						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GCGCTGGATCACTGTAGGTGC	0.632000													5	15					0	0	1	0	0
PACRG	135138	broad.mit.edu	37	6	163235234	163235234	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:163235234C>T	ENST00000337019.3	+	3	436	c.212C>T	c.(211-213)gCa>gTa	p.A71V	PACRG_ENST00000542669.1_3'UTR|PACRG_ENST00000366889.2_Missense_Mutation_p.A71V|PACRG_ENST00000366888.2_Missense_Mutation_p.A71V	NM_152410.2	NP_689623.2	Q96M98	PACRG_HUMAN	PARK2 co-regulated	71										endometrium(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		AAGCCCACAGCATTTCGAAAA	0.448000													19	105					0	0	1	0	0
NAT9	26151	broad.mit.edu	37	17	72769791	72769791	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:72769791C>A	ENST00000357814.3	-	3	187	c.114G>T	c.(112-114)caG>caT	p.Q38H	NAT9_ENST00000582524.1_Missense_Mutation_p.Q38H|NAT9_ENST00000580632.1_Missense_Mutation_p.Q37H|NAT9_ENST00000580301.1_Missense_Mutation_p.Q37H|NAT9_ENST00000578822.1_Missense_Mutation_p.Q43H|NAT9_ENST00000580216.1_5'UTR|NAT9_ENST00000583757.1_Missense_Mutation_p.Q37H|NAT9_ENST00000582870.1_Missense_Mutation_p.Q42H|NAT9_ENST00000581136.1_Missense_Mutation_p.Q38H|NAT9_ENST00000583476.1_Missense_Mutation_p.Q38H	NM_015654.3	NP_056469.2	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9 (GCN5-related, putative)	38	N-acetyltransferase.					protein complex	N-acetyltransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)	8						CTGTCAAACGCTGCAGCTCCT	0.577000													17	36					5.03518e-11	5.40566e-11	1	1	0
SENP1	29843	broad.mit.edu	37	12	48477397	48477397	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48477397G>A	ENST00000004980.5	-	6	1007	c.529C>T	c.(529-531)Cga>Tga	p.R177*	SENP1_ENST00000549595.1_Nonsense_Mutation_p.R177*|SENP1_ENST00000549518.1_Nonsense_Mutation_p.R177*|SENP1_ENST00000448372.1_Nonsense_Mutation_p.R177*|SENP1_ENST00000547886.1_5'UTR|SENP1_ENST00000551330.1_Nonsense_Mutation_p.R177*|SENP1_ENST00000339976.6_3'UTR			Q9P0U3	SENP1_HUMAN	SUMO1/sentrin specific peptidase 1	177					activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			large_intestine(3)|lung(1)|pancreas(2)|stomach(1)	7		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				CTAACATGTCGCCTCTGAGTT	0.398000													10	16					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306040	2306040	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:2306040G>A	ENST00000290974.2	-	8	2366	c.2027C>T	c.(2026-2028)gCg>gTg	p.A676V	ZFYVE28_ENST00000511071.1_Missense_Mutation_p.A646V|RP11-478C1.7_ENST00000510632.1_RNA|ZFYVE28_ENST00000515312.1_Missense_Mutation_p.A606V	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	676					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GGCCTGAGGCGCCTCGTGAGC	0.662000													20	29					0	0	1	0	0
CARD14	79092	broad.mit.edu	37	17	78169064	78169064	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:78169064G>A	ENST00000573882.1	+	12	1967	c.1431G>A	c.(1429-1431)gcG>gcA	p.A477A	CARD14_ENST00000344227.2_Silent_p.A477A|CARD14_ENST00000570421.1_Silent_p.A477A|CARD14_ENST00000573754.1_3'UTR|CARD14_ENST00000392434.2_Silent_p.A240A			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	477					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GCAGCCCCGCGCCCCCCAGCC	0.657000													19	1					0	0	1	0	0
TMCO3	55002	broad.mit.edu	37	13	114164673	114164673	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:114164673C>A	ENST00000434316.2	+	7	1518	c.1159C>A	c.(1159-1161)Ctg>Atg	p.L387M	TMCO3_ENST00000474393.1_3'UTR|TMCO3_ENST00000375391.1_Missense_Mutation_p.L387M	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	387						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			TTCCACGTGTCTGTCCTTGTC	0.532000													41	50					2.00842e-17	2.21064e-17	1	1	0
SMPD4	55627	broad.mit.edu	37	2	130930032	130930032	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:130930032G>T	ENST00000409031.1	-	8	1814	c.666C>A	c.(664-666)gcC>gcA	p.A222A	SMPD4_ENST00000453750.1_Intron|SMPD4_ENST00000339679.7_Silent_p.A109A|SMPD4_ENST00000426662.2_Intron|SMPD4_ENST00000431183.2_Silent_p.A149A|SMPD4_ENST00000452225.2_Intron|SMPD4_ENST00000443958.2_Intron|SMPD4_ENST00000351288.6_Silent_p.A222A|SMPD4_ENST00000473720.1_Intron	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	183					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GGATGAAATAGGCACAGTCTG	0.602000													13	13					0.00244969	0.00248438	1	1	0
NFKB1	4790	broad.mit.edu	37	4	103498131	103498131	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:103498131G>A	ENST00000226574.4	+	7	973	c.506G>A	c.(505-507)gGa>gAa	p.G169E	NFKB1_ENST00000510638.1_3'UTR|NFKB1_ENST00000505458.1_Missense_Mutation_p.G168E|NFKB1_ENST00000394820.4_Missense_Mutation_p.G168E	NM_001165412.1|NM_003998.3	NP_001158884.1|NP_003989.2	P19838	NFKB1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	168	RHD.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			biliary_tract(1)|breast(4)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	TATAATCCTGGACTCTTGGTG	0.493000													21	27					0	0	1	0	0
PRAMEF6	440561	broad.mit.edu	37	1	13001190	13001190	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:13001190T>C	ENST00000376189.1	-	3	592	c.493A>G	c.(493-495)Acc>Gcc	p.T165A	PRAMEF6_ENST00000415464.2_Missense_Mutation_p.T165A|PRAMEF6_ENST00000376192.5_Intron	NM_001010889.2	NP_001010889.1	Q5VXH4	PRAM6_HUMAN	PRAME family member 6	165										NS(1)|kidney(1)|lung(5)|urinary_tract(2)	9	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGGAGGCAGGTGAGGTATTCA	0.473000													33	238					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88938739	88938739	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:88938739C>T	ENST00000556564.1	-	15	3004	c.2720G>A	c.(2719-2721)cGg>cAg	p.R907Q	PTPN21_ENST00000328736.3_Missense_Mutation_p.R907Q	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	907	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						ATCAACTAGCCGTTTCTTAAG	0.368000													15	39					0	0	1	0	0
PHF14	9678	broad.mit.edu	37	7	11030335	11030335	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:11030335G>A	ENST00000403050.3	+	4	1358	c.906G>A	c.(904-906)tcG>tcA	p.S302S	PHF14_ENST00000445996.2_Silent_p.S17S	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	302							zinc ion binding			NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		ATTAGGACTCGCTGATTCTTG	0.284000													4	4					0	0	1	0	0
LARP4	113251	broad.mit.edu	37	12	50824352	50824352	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:50824352C>T	ENST00000398473.2	+	4	509	c.398_splice	c.e4+1	p.R133_splice	LARP4_ENST00000429001.3_Splice_Site_p.R139_splice|LARP4_ENST00000293618.8_Splice_Site_p.R133_splice|LARP4_ENST00000518444.1_Splice_Site_p.R132_splice|LARP4_ENST00000347328.5_Splice_Site_p.R133_splice|LARP4_ENST00000518561.1_Splice_Site_p.R63_splice|LARP4_ENST00000522085.1_Splice_Site_p.R133_splice	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	133	HTH La-type RNA-binding.						nucleotide binding|RNA binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						CTGTTTTTCACGGTATTGCTG	0.313000													13	18					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88414105	88414105	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:88414105A>G	ENST00000261304.2	-	13	1562	c.1456T>C	c.(1456-1458)Ttc>Ctc	p.F486L	GALC_ENST00000544807.2_Missense_Mutation_p.F430L|GALC_ENST00000393568.4_Missense_Mutation_p.F463L|GALC_ENST00000393569.2_Missense_Mutation_p.F460L	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	486					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GTACTTGGGAAGGGCTGGGAT	0.438000													15	51					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231977	21231977	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:21231977G>T	ENST00000233242.1	-	26	7890	c.7763C>A	c.(7762-7764)cCt>cAt	p.P2588H		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2588					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTTGATTTCAGGAACAGTGAA	0.448000													31	41					9.65021e-13	1.04556e-12	1	1	0
CDH6	1004	broad.mit.edu	37	5	31267787	31267787	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:31267787C>T	ENST00000265071.2	+	2	472	c.207C>T	c.(205-207)tcC>tcT	p.S69S	CDH6_ENST00000514738.1_Silent_p.S14S	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	69	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						ACACAGGATCCGATTATCAGT	0.448000													18	36					0	0	1	0	0
RELT	84957	broad.mit.edu	37	11	73103308	73103308	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:73103308C>T	ENST00000064780.2	+	6	681	c.420C>T	c.(418-420)agC>agT	p.S140S	RELT_ENST00000393580.2_Silent_p.S140S	NM_152222.1	NP_689408.1	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor	140						cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	12						GGGCCAGCAGCGGTGGTGAGA	0.672000													9	13					0	0	1	0	0
LRAT	9227	broad.mit.edu	37	4	155665867	155665867	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:155665867C>T	ENST00000336356.3	+	2	642	c.389C>T	c.(388-390)tCc>tTc	p.S130F	LRAT_ENST00000507827.1_Missense_Mutation_p.S130F	NM_004744.3	NP_004735.2	O95237	LRAT_HUMAN	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)	130					response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)	16	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	CTGGACGAGTCCCTCCAGAAA	0.582000													5	21					0	0	1	0	0
DDX19B	11269	broad.mit.edu	37	16	70363937	70363937	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:70363937C>T	ENST00000288071.6	+	9	1234	c.989C>T	c.(988-990)gCc>gTc	p.A330V	DDX19B_ENST00000563392.1_Missense_Mutation_p.A221V|DDX19B_ENST00000393657.2_Missense_Mutation_p.A221V|DDX19B_ENST00000451014.3_Missense_Mutation_p.A304V|RP11-529K1.3_ENST00000567706.1_Intron|RP11-529K1.2_ENST00000562077.1_RNA|DDX19B_ENST00000563206.1_Missense_Mutation_p.A335V|DDX19B_ENST00000568625.1_Missense_Mutation_p.A221V|DDX19B_ENST00000355992.3_Missense_Mutation_p.A299V	NM_007242.5	NP_009173.1	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B	330	Helicase C-terminal.				mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)	9		Ovarian(137;0.0694)				CTCTACGGGGCCATCACCATT	0.577000													40	48					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73662152	73662152	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:73662152G>A	ENST00000339764.1	+	1	789	c.38G>A	c.(37-39)cGc>cAc	p.R13H		NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	13	J.				apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					GGGATCACTCGCAATTCAGAG	0.582000													5	14					0	0	1	0	0
THUMPD3	25917	broad.mit.edu	37	3	9413002	9413002	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9413002G>A	ENST00000345094.3	+	4	923	c.589G>A	c.(589-591)Gta>Ata	p.V197I	THUMPD3_ENST00000515662.2_Missense_Mutation_p.V197I|THUMPD3_ENST00000452837.2_Missense_Mutation_p.V197I|SETD5-AS1_ENST00000468186.1_RNA	NM_001114092.1|NM_015453.2	NP_001107564.1|NP_056268.2	Q9BV44	THUM3_HUMAN	THUMP domain containing 3	197	THUMP.						methyltransferase activity|protein binding|RNA binding			NS(1)|central_nervous_system(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	19	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.101)		CAAAGAGGATGTATCAACATT	0.353000													23	34					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	597506	597506	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:597506G>A	ENST00000264555.5	+	8	958	c.830G>A	c.(829-831)cGg>cAg	p.R277Q	PHRF1_ENST00000413872.2_Missense_Mutation_p.R276Q|PHRF1_ENST00000533464.1_Missense_Mutation_p.R273Q|PHRF1_ENST00000416188.2_Missense_Mutation_p.R277Q	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	277	Arg-rich.						RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						GCCAGGACACGGCAGAGTGAG	0.652000													7	9					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81864721	81864721	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:81864721C>T	ENST00000555447.1	-	3	418	c.6G>A	c.(4-6)acG>acA	p.T2T	STON2_ENST00000267540.2_Silent_p.T2T	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	2					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GGTCCAAAGTCGTCATGCTAA	0.537000													7	11					0	0	1	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	73953041	73953041	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:73953041G>A	ENST00000476977.1	+	13	3170	c.1479G>A	c.(1477-1479)ccG>ccA	p.P493P	GTF2IRD1_ENST00000489094.1_3'UTR|GTF2IRD1_ENST00000424337.2_Silent_p.P493P|GTF2IRD1_ENST00000455841.2_Silent_p.P525P|GTF2IRD1_ENST00000265755.3_Silent_p.P493P			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	493						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GGCTGAGGCCGATCAAAATTG	0.582000													20	31					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57515244	57515244	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:57515244C>T	ENST00000374900.4	+	11	1598	c.1478C>T	c.(1477-1479)gCc>gTc	p.A493V	FAAH2_ENST00000491179.1_3'UTR	NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	493						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						GGACTGAATGCCAAAGGACTC	0.502000										HNSCC(52;0.14)			16	18					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147114235	147114235	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:147114235C>T	ENST00000383075.3	-	3	604	c.92G>A	c.(91-93)gGc>gAc	p.G31D	ZIC4_ENST00000491672.1_Intron|ZIC4_ENST00000425731.3_Missense_Mutation_p.G69D|ZIC4_ENST00000484399.1_Missense_Mutation_p.G31D|ZIC4_ENST00000525172.2_Missense_Mutation_p.G81D|ZIC4_ENST00000473123.1_Missense_Mutation_p.G31D	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	31						nucleus	DNA binding|zinc ion binding	p.G31D(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						GAGCTGGGGGCCATGGTGTCC	0.692000													14	36					0	0	1	0	0
CORO6	84940	broad.mit.edu	37	17	27945843	27945843	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27945843G>A	ENST00000345068.5	-	5	811	c.598C>T	c.(598-600)Cgc>Tgc	p.R200C	RP11-68I3.2_ENST00000581474.1_RNA|CORO6_ENST00000388767.3_Missense_Mutation_p.R200C|CORO6_ENST00000584969.1_Missense_Mutation_p.R200C|CORO6_ENST00000577909.1_Intron|CORO6_ENST00000580212.1_Missense_Mutation_p.R200C|CORO6_ENST00000445145.2_Missense_Mutation_p.R200C			Q6QEF8	CORO6_HUMAN	coronin 6	200					actin cytoskeleton organization	actin cytoskeleton	actin filament binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(2)	14						TCAATGATGCGCAAGGTCTTG	0.597000													7	10					0	0	1	0	0
ATAD3C	219293	broad.mit.edu	37	1	1387776	1387776	+	Missense_Mutation	SNP	C	C	T	rs144852834	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1387776C>T	ENST00000378785.2	+	3	1179	c.184C>T	c.(184-186)Cgt>Tgt	p.R62C		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	62							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGAAGGATTCCGTGCCTTTGT	0.577000													25	117					0	0	1	0	0
CA13	377677	broad.mit.edu	37	8	86178874	86178874	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:86178874G>A	ENST00000321764.3	+	4	694	c.392G>A	c.(391-393)aGc>aAc	p.S131N	CA13_ENST00000517298.1_3'UTR	NM_198584.2	NP_940986.1	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	131					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			large_intestine(1)|lung(6)	7						AAATACCCCAGCTTTGTTGAG	0.398000													11	39					0	0	1	0	0
DDX24	57062	broad.mit.edu	37	14	94528809	94528809	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:94528809C>T	ENST00000330836.5	-	3	1008	c.877G>A	c.(877-879)Gct>Act	p.A293T	DDX24_ENST00000544005.1_Missense_Mutation_p.A43T|DDX24_ENST00000555054.1_Missense_Mutation_p.A250T	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	293	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		TCAGACTCAGCTTCAGCCTTG	0.552000													22	37					0	0	1	0	0
P4HB	5034	broad.mit.edu	37	17	79803786	79803786	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79803786C>T	ENST00000331483.4	-	8	1360	c.1138G>A	c.(1138-1140)Gtg>Atg	p.V380M	P4HB_ENST00000576390.1_Intron|P4HB_ENST00000439918.2_Missense_Mutation_p.V336M	NM_000918.3	NP_000909.2	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta polypeptide	380	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			NS(1)|breast(1)|large_intestine(2)|lung(17)|urinary_tract(1)	22	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			TCAAAAGCCACGTCTTCAAAG	0.572000													12	14					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54647752	54647752	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54647752G>A	ENST00000406403.1	+	5	1872	c.269G>A	c.(268-270)cGg>cAg	p.R90Q	CNOT3_ENST00000221232.5_Missense_Mutation_p.R90Q|CNOT3_ENST00000358389.3_5'UTR			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	90					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CAAATGGAACGGTTCAAAGTT	0.557000													33	46					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35288352	35288352	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:35288352C>A	ENST00000408931.3	-	3	1008	c.482G>T	c.(481-483)cGc>cTc	p.R161L		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	161						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						GTAGGCGTAGCGGTACCTCTT	0.572000													16	31					4.14922e-12	4.48033e-12	1	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18887911	18887911	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:18887911G>A	ENST00000380548.4	+	24	4671	c.4332G>A	c.(4330-4332)acG>acA	p.T1444T	ADAMTSL1_ENST00000380545.5_Silent_p.T145T	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1444	Ig-like C2-type 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CAGGACTGACGCATCACATCT	0.532000													14	20					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105509341	105509341	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:105509341C>T	ENST00000276654.5	-	5	1547	c.1439G>A	c.(1438-1440)aGc>aAc	p.S480N	LRP12_ENST00000424843.2_Missense_Mutation_p.S461N	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	480	LDL-receptor class A 5.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TTCTTCATCGCTGCCATCACC	0.448000													27	48					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116307451	116307451	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:116307451C>T	ENST00000369252.4	-	5	879	c.578G>A	c.(577-579)tGc>tAc	p.C193Y	ABLIM1_ENST00000533213.2_Missense_Mutation_p.C193Y|ABLIM1_ENST00000277895.5_Missense_Mutation_p.C253Y	NM_001003407.1|NM_001003408.1	NP_001003407.1|NP_001003408.1	O14639	ABLM1_HUMAN	actin binding LIM protein 1	253	LIM zinc-binding 2.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		GCAGGACTTGCATTTAAAGCA	0.587000													16	20					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209217388	209217388	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:209217388C>T	ENST00000264380.4	+	39	5884	c.5726C>T	c.(5725-5727)gCg>gTg	p.A1909V		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1909	Catalytic.|PIPK.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						AGGCCCACGGCGTTGGCCAAA	0.328000													19	39					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21990620	21990620	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:21990620C>T	ENST00000594012.1	-	7	2715	c.2201G>A	c.(2200-2202)gGc>gAc	p.G734D	ZNF43_ENST00000598381.1_Missense_Mutation_p.G734D|ZNF43_ENST00000595461.1_Missense_Mutation_p.G734D|ZNF43_ENST00000354959.4_Missense_Mutation_p.G740D	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	740					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		AAATGCTTTGCCACATTCTTC	0.348000													22	41					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149216274	149216274	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149216274C>T	ENST00000309241.5	+	8	2288	c.2256C>T	c.(2254-2256)agC>agT	p.S752S	PPARGC1B_ENST00000403750.1_Silent_p.S688S|PPARGC1B_ENST00000360453.4_Silent_p.S713S|PPARGC1B_ENST00000394320.3_Silent_p.S752S	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	752					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CCAAGGACAGCACGCTGCTGA	0.647000													27	40					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735752	55735752	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55735752C>T	ENST00000312345.2	-	1	238	c.188G>A	c.(187-189)tGt>tAt	p.C63Y		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					TGTTACATAACAGATTTCCAA	0.343000													4	61					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49643082	49643082	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49643082G>A	ENST00000334186.4	+	17	2583	c.2234G>A	c.(2233-2235)cGg>cAg	p.R745Q	PPFIA3_ENST00000602351.1_Missense_Mutation_p.R745Q	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	745						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GGACCCCCACGGGGAAGGTCA	0.642000													12	14					0	0	1	0	0
FOXC1	2296	broad.mit.edu	37	6	1612302	1612302	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:1612302G>A	ENST00000380874.2	+	1	1622	c.1622G>A	c.(1621-1623)cGc>cAc	p.R541H		NM_001453.2	NP_001444.2	Q12948	FOXC1_HUMAN	forkhead box C1	541					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		TCTCTGTACCGCACGTCCGGA	0.512000													10	17					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43017806	43017806	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43017806G>A	ENST00000535468.1	-	6	1802	c.1716C>T	c.(1714-1716)caC>caT	p.H572H	CUL7_ENST00000265348.3_Silent_p.H488H	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	488					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCAGGGTCAGGTGTTCACACT	0.552000													10	53					0	0	1	0	0
MEGF11	84465	broad.mit.edu	37	15	66206195	66206195	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:66206195C>T	ENST00000409699.2	-	20	2762	c.2590G>A	c.(2590-2592)Gtg>Atg	p.V864M	MEGF11_ENST00000395625.2_Missense_Mutation_p.V789M|MEGF11_ENST00000478721.1_5'UTR|MEGF11_ENST00000288745.3_Missense_Mutation_p.V789M|MEGF11_ENST00000360698.4_3'UTR|MEGF11_ENST00000395614.1_Missense_Mutation_p.V37M|MEGF11_ENST00000422354.1_Missense_Mutation_p.V864M			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	864						basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						CCCAGCAGCACCACAATGAGG	0.602000													14	21					0	0	1	0	0
MAP2K6	5608	broad.mit.edu	37	17	67501929	67501929	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:67501929C>T	ENST00000590474.1	+	2	312	c.25C>T	c.(25-27)Cga>Tga	p.R9*	MAP2K6_ENST00000589647.1_5'UTR	NM_002758.3	NP_002749.2	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	9					activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	20	Breast(10;6.05e-10)					AGGCAAGAAGCGAAACCCTGG	0.428000													30	52					0	0	1	0	0
PPP1R17	10842	broad.mit.edu	37	7	31736606	31736606	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:31736606G>T	ENST00000342032.3	+	4	891	c.263G>T	c.(262-264)aGa>aTa	p.R88I	PPP1R17_ENST00000409146.3_Missense_Mutation_p.R37I|PPP1R17_ENST00000498609.1_3'UTR	NM_006658.4	NP_006649.2	O96001	GSUB_HUMAN	protein phosphatase 1, regulatory subunit 17	88					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction		p.R88I(1)									TTAATTAAAAGATACGATGTT	0.393000													27	40					2.81731e-10	3.0079e-10	1	1	0
MCF2L	23263	broad.mit.edu	37	13	113741739	113741739	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113741739C>A	ENST00000397030.1	+	22	2700	c.2663C>A	c.(2662-2664)gCt>gAt	p.A888D	MCF2L_ENST00000442652.2_Missense_Mutation_p.A885D|MCF2L_ENST00000421756.1_Missense_Mutation_p.A859D|MCF2L_ENST00000375597.4_Missense_Mutation_p.A853D|MCF2L_ENST00000375608.3_Missense_Mutation_p.A885D|MCF2L_ENST00000535094.2_Missense_Mutation_p.A855D|MCF2L_ENST00000434480.2_Missense_Mutation_p.A861D|MCF2L_ENST00000375604.2_Missense_Mutation_p.A912D|MCF2L_ENST00000375601.3_Missense_Mutation_p.A859D|MCF2L_ENST00000423482.2_Missense_Mutation_p.A853D			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	885	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TATGAGAAAGCTCCCTCCTAC	0.592000													7	8					0.00198382	0.0020125	1	1	0
RELT	84957	broad.mit.edu	37	11	73105729	73105729	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:73105729C>T	ENST00000064780.2	+	9	1257	c.996C>T	c.(994-996)gcC>gcT	p.A332A	RELT_ENST00000393580.2_Silent_p.A332A	NM_152222.1	NP_689408.1	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor	332			A -> V (in dbSNP:rs12362779).			cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	12						TTCCCAAGGCCGGGGCCAAGG	0.637000													7	23					0	0	1	0	0
PPP1R1B	84152	broad.mit.edu	37	17	37791876	37791876	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:37791876C>A	ENST00000254079.4	+	6	931	c.462C>A	c.(460-462)acC>acA	p.T154T	PPP1R1B_ENST00000394265.1_Silent_p.T118T|PPP1R1B_ENST00000580825.1_Silent_p.T154T|PPP1R1B_ENST00000579000.1_Silent_p.T121T|PPP1R1B_ENST00000394267.2_Silent_p.T118T	NM_032192.3	NP_115568.2	Q9UD71	PPR1B_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1B	154					signal transduction	cytosol	protein kinase inhibitor activity|protein phosphatase inhibitor activity			kidney(1)|large_intestine(1)|liver(1)|lung(2)	5	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			AAAAGACAACCTGTGGCCAGG	0.582000													43	45					7.05121e-23	7.84975e-23	1	1	0
SLITRK2	84631	broad.mit.edu	37	X	144904206	144904206	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:144904206C>T	ENST00000370490.1	+	1	4518	c.263C>T	c.(262-264)gCg>gTg	p.A88V	SLITRK2_ENST00000428560.2_Missense_Mutation_p.A88V|SLITRK2_ENST00000413937.2_Missense_Mutation_p.A88V|SLITRK2_ENST00000434188.2_Missense_Mutation_p.A88V|SLITRK2_ENST00000447897.2_Missense_Mutation_p.A88V			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	88						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					TACTCCAACGCGGTGACTCTT	0.473000													14	36					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31302310	31302310	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31302310G>A	ENST00000332585.6	+	14	2839	c.2735G>A	c.(2734-2736)tGc>tAc	p.C912Y	OSBP2_ENST00000382310.3_3'UTR|OSBP2_ENST00000407373.1_Missense_Mutation_p.C739Y|OSBP2_ENST00000535268.1_Missense_Mutation_p.C456Y|OSBP2_ENST00000401475.1_Missense_Mutation_p.C545Y|OSBP2_ENST00000403222.3_Missense_Mutation_p.C746Y|OSBP2_ENST00000446658.2_Missense_Mutation_p.C911Y|OSBP2_ENST00000437268.2_Missense_Mutation_p.C655Y	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	912					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						TGGCATATGTGCCCCAACATC	0.547000													21	34					0	0	1	0	0
ZMYM1	79830	broad.mit.edu	37	1	35563119	35563119	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:35563119C>A	ENST00000373330.1	+	5	545	c.371C>A	c.(370-372)tCt>tAt	p.S124Y	ZMYM1_ENST00000359858.4_Missense_Mutation_p.S124Y|ZMYM1_ENST00000373329.1_3'UTR			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	124						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TACATTTCATCTGCCAGTTCA	0.388000													44	64					1.57945e-13	1.71745e-13	1	1	0
DNAH11	8701	broad.mit.edu	37	7	21827038	21827038	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:21827038C>T	ENST00000328843.6	+	61	9813	c.9782C>T	c.(9781-9783)gCa>gTa	p.A3261V	DNAH11_ENST00000409508.3_Missense_Mutation_p.A3254V			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3261	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTTTTGCAAGCATTAATTAAC	0.343000									Kartagener syndrome				14	32					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34269142	34269142	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:34269142C>T	ENST00000346562.2	+	11	1607	c.1533C>T	c.(1531-1533)ggC>ggT	p.G511G	NPAS3_ENST00000356141.4_Silent_p.G543G|NPAS3_ENST00000551492.1_Silent_p.G548G|NPAS3_ENST00000548645.1_Silent_p.G513G|NPAS3_ENST00000357798.5_Silent_p.G530G	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	543					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CCAAGGCGGGCGAGGACGGCT	0.632000													6	14					0	0	1	0	0
EPRS	2058	broad.mit.edu	37	1	220156131	220156131	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:220156131C>T	ENST00000366923.3	-	23	3625	c.3356G>A	c.(3355-3357)cGt>cAt	p.R1119H		NM_004446.2	NP_004437.2	P07814	SYEP_HUMAN	glutamyl-prolyl-tRNA synthetase	1119	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			breast(2)|endometrium(11)|kidney(2)|large_intestine(13)|lung(24)|ovary(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(3)	63				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	ACTAGTAGGACGAATGGCAAT	0.403000													38	70					0	0	1	0	0
PIDD	55367	broad.mit.edu	37	11	800378	800378	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:800378G>A	ENST00000347755.5	-	13	2256	c.2115C>T	c.(2113-2115)taC>taT	p.Y705Y	PIDD_ENST00000411829.2_Intron	NM_145886.3|NM_145887.3	NP_665893.2|NP_665894.2	Q9HB75	PIDD_HUMAN	p53-induced death domain protein	705					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding										TGGTGGTCACGTATACCTCCT	0.642000													15	23					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14787073	14787073	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:14787073G>T	ENST00000358984.4	+	15	1888	c.1708G>T	c.(1708-1710)Gat>Tat	p.D570Y	ANKRD30B_ENST00000447268.2_Missense_Mutation_p.D570Y|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	570										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						ACAAAAGGACGATGAAGAAAA	0.289000													5	46					0.014758	0.0148771	1	1	0
RP11-24M17.5	0	broad.mit.edu	37	15	76075521	76075521	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:76075521G>A	ENST00000395215.3	+	0	1161																											gagaggctgcgaaagcaggaa	0.607000													6	218					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59377913	59377913	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:59377913C>T	ENST00000348370.4	+	10	2912	c.2479C>T	c.(2479-2481)Cat>Tat	p.H827Y	RNF111_ENST00000561186.1_Missense_Mutation_p.H836Y|RNF111_ENST00000434298.1_Missense_Mutation_p.H836Y|RNF111_ENST00000559209.1_Missense_Mutation_p.H836Y|RNF111_ENST00000557998.1_Missense_Mutation_p.H827Y	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	827					multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		TGGTGCATTGCATCCTCACTT	0.418000													4	87					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5303789	5303789	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:5303789C>T	ENST00000274181.7	+	20	3234	c.3096C>T	c.(3094-3096)tcC>tcT	p.S1032S		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	1032	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TCTGCACCTCCGAGCCCAAGC	0.652000													5	24					0	0	1	0	0
RFC3	5983	broad.mit.edu	37	13	34404122	34404122	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:34404122G>A	ENST00000380071.3	+	5	671	c.541G>A	c.(541-543)Gcg>Acg	p.A181T	RFC3_ENST00000434425.1_Missense_Mutation_p.A181T	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	181					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		TAGGTGCTTGGCGGTTCGTGT	0.403000													29	53					0	0	1	0	0
GSK3A	2931	broad.mit.edu	37	19	42736822	42736822	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42736822G>A	ENST00000398249.4	-	8	2578	c.865C>T	c.(865-867)Cga>Tga	p.R289*	GSK3A_ENST00000222330.3_Nonsense_Mutation_p.R371*			P49840	GSK3A_HUMAN	glycogen synthase kinase 3 alpha	371	Protein kinase.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of transferase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process	beta-catenin destruction complex|cytosol	ATP binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|tau-protein kinase activity			endometrium(3)|large_intestine(3)|lung(6)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	19		Prostate(69;0.00682)				GGCGGCGTTCGAGATTTGAAC	0.592000													6	12					0	0	1	0	0
RASEF	158158	broad.mit.edu	37	9	85615852	85615852	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:85615852C>T	ENST00000376447.3	-	10	1656	c.1396G>A	c.(1396-1398)Ggg>Agg	p.G466R		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	466					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding	p.G466R(1)		NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TCCTGCACCCCGTGTGACCTC	0.502000													8	41					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65162627	65162627	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:65162627C>T	ENST00000358691.5	-	15	2028	c.1862G>A	c.(1861-1863)aGt>aAt	p.S621N	HELZ_ENST00000580168.1_Missense_Mutation_p.S621N	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GGGAGTCATACTGATGTCTGG	0.368000													35	51					0	0	1	0	0
NUP107	57122	broad.mit.edu	37	12	69094603	69094603	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:69094603T>C	ENST00000229179.4	+	7	982	c.650T>C	c.(649-651)gTc>gCc	p.V217A	NUP107_ENST00000539906.1_Missense_Mutation_p.V188A|NUP107_ENST00000378905.2_Missense_Mutation_p.V66A	NM_020401.2	NP_065134.1	P57740	NU107_HUMAN	nucleoporin 107kDa	217					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			CAGGAGATGGTCACATGGAGG	0.373000													33	45					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80762088	80762088	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:80762088C>T	ENST00000458043.2	+	54	6593	c.6588_splice	c.e54+1	p.A2196_splice	OTOGL_ENST00000547103.1_Splice_Site_p.A2184_splice|OTOGL_ENST00000546620.1_Splice_Site_p.A215_splice	NM_173591.3	NP_775862.3			otogelin-like									p.A2196V(2)|p.A561V(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						GTTGTATACGCGGTATGTTTC	0.428000													3	5					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15739226	15739226	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:15739226C>T	ENST00000441682.2	+	0	1291							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						TGCTCCCAGACAGCCGAGTCA	0.642000													11	51					0	0	1	0	0
NPM3	10360	broad.mit.edu	37	10	103541551	103541551	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:103541551T>C	ENST00000370110.5	-	5	501	c.479A>G	c.(478-480)gAg>gGg	p.E160G	NPM3_ENST00000474993.1_5'UTR	NM_006993.2	NP_008924.1	O75607	NPM3_HUMAN	nucleophosmin/nucleoplasmin 3	160	Asp/Glu-rich (highly acidic).						nucleic acid binding			large_intestine(3)|lung(1)|skin(1)	5		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		AACTTCTTCCTCATCACTGTC	0.547000											OREG0020469	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	98					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35591985	35591985	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:35591985G>A	ENST00000353139.5	-	25	3632	c.3151C>T	c.(3151-3153)Cga>Tga	p.R1051*	ACACA_ENST00000394406.2_Nonsense_Mutation_p.R1014*|ACACA_ENST00000360679.3_Nonsense_Mutation_p.R956*|ACACA_ENST00000335166.5_Nonsense_Mutation_p.R936*	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1014					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TTCTCTTCTCGGAGGGCGAAT	0.393000													29	54					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57860573	57860573	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:57860573C>T	ENST00000381227.1	+	5	660	c.247C>T	c.(247-249)Cga>Tga	p.R83*	POLR2B_ENST00000441246.2_Nonsense_Mutation_p.R76*|POLR2B_ENST00000314595.5_Nonsense_Mutation_p.R83*|POLR2B_ENST00000431623.2_Nonsense_Mutation_p.R8*			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	83					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					ATTTCAGCCACGATATTTGCT	0.318000													13	18					0	0	1	0	0
ZNF362	149076	broad.mit.edu	37	1	33747315	33747315	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33747315G>A	ENST00000539719.1	+	6	981	c.811G>A	c.(811-813)Gcc>Acc	p.A271T	ZNF362_ENST00000373428.5_Missense_Mutation_p.A271T	NM_152493.2	NP_689706.2	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(4)|lung(2)	10		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CTCCTACCTGGCCCAGCACCT	0.612000													35	43					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23858175	23858175	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23858175C>T	ENST00000405093.3	-	29	4138	c.4068G>A	c.(4066-4068)aaG>aaA	p.K1356K	MYH6_ENST00000356287.3_Silent_p.K1356K	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1356					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCAGCTCGGCCTTGGCCTCTG	0.662000													13	36					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207135710	207135710	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:207135710C>T	ENST00000324852.4	-	5	974	c.500G>A	c.(499-501)cGt>cAt	p.R167H	FCAMR_ENST00000400962.3_Missense_Mutation_p.R167H|FCAMR_ENST00000450945.2_Missense_Mutation_p.R167H	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	122	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						CACACGGTCACGATAGCGATG	0.567000													6	26					0	0	1	0	0
RAE1	8480	broad.mit.edu	37	20	55948750	55948750	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:55948750C>T	ENST00000395841.2	+	10	1201	c.781C>T	c.(781-783)Cga>Tga	p.R261*	RAE1_ENST00000371242.2_Nonsense_Mutation_p.R261*|RAE1_ENST00000395840.2_Nonsense_Mutation_p.R261*|RAE1_ENST00000527947.1_Nonsense_Mutation_p.R261*	NM_003610.3	NP_003601.1	P78406	RAE1L_HUMAN	ribonucleic acid export 1	261					carbohydrate metabolic process|glucose transport|mRNA export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|cytoskeleton|nuclear outer membrane|nuclear pore	microtubule binding|RNA binding	p.R261*(1)		breast(1)|endometrium(5)|large_intestine(4)|lung(6)|prostate(3)|skin(2)	21	Lung NSC(12;0.00263)|all_lung(29;0.00828)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;3.7e-14)|Epithelial(14;1.07e-09)|all cancers(14;1.11e-08)			TAAATGTCATCGATCTAATGG	0.403000													5	209					0	0	1	0	0
ZNF142	7701	broad.mit.edu	37	2	219508081	219508081	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219508081C>T	ENST00000411696.2	-	7	3937	c.3158G>A	c.(3157-3159)cGt>cAt	p.R1053H	ZNF142_ENST00000449707.1_Missense_Mutation_p.R1053H			P52746	ZN142_HUMAN	zinc finger protein 142	1053					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TCCCCCGCCACGTCCCCCCCT	0.607000													11	44					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80808885	80808885	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:80808885C>T	ENST00000466387.1	+	18	2672	c.1948C>T	c.(1948-1950)Cgt>Tgt	p.R650C	CTNNA2_ENST00000496558.1_Missense_Mutation_p.R650C|AC008067.2_ENST00000596887.1_RNA|AC008067.2_ENST00000430876.1_RNA|CTNNA2_ENST00000541047.1_Missense_Mutation_p.R650C|CTNNA2_ENST00000361291.4_Missense_Mutation_p.R684C|CTNNA2_ENST00000402739.4_Missense_Mutation_p.R650C|CTNNA2_ENST00000540488.1_Missense_Mutation_p.R650C|CTNNA2_ENST00000343114.3_Missense_Mutation_p.R329C			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	650					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TTATGATGTGCGTAGCAGGAC	0.458000													13	12					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73169736	73169736	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:73169736C>T	ENST00000286657.4	-	17	2358	c.2322G>A	c.(2320-2322)tcG>tcA	p.S774S		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	774	Spacer.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGAAGGTCCGCGACTTGGCTT	0.393000													61	86					0	0	1	0	0
C19orf47	126526	broad.mit.edu	37	19	40834430	40834430	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:40834430A>C	ENST00000582783.1	-	6	452	c.440T>G	c.(439-441)cTg>cGg	p.L147R	C19orf47_ENST00000392035.2_Missense_Mutation_p.L80R	NM_001256440.1	NP_001243369.1	Q8N9M1	CS047_HUMAN	chromosome 19 open reading frame 47	147										endometrium(5)|kidney(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20			Lung(22;0.000636)			GTCATGGTTCAGGCTGTTGGT	0.607000													27	101					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42694485	42694485	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:42694485G>A	ENST00000358131.5	+	6	1248	c.1040G>A	c.(1039-1041)cGc>cAc	p.R347H	TOX2_ENST00000423191.1_Missense_Mutation_p.R323H|TOX2_ENST00000435864.2_Missense_Mutation_p.R243H|TOX2_ENST00000372999.1_Missense_Mutation_p.R323H|TOX2_ENST00000341197.3_Missense_Mutation_p.R365H	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CAGGCCTTCCGCAGTGGGGCC	0.697000													23	25					0	0	1	0	0
SUSD5	26032	broad.mit.edu	37	3	33194726	33194726	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:33194726C>T	ENST00000309558.3	-	5	1815	c.1398G>A	c.(1396-1398)acG>acA	p.T466T		NM_015551.1	NP_056366.1	O60279	SUSD5_HUMAN	sushi domain containing 5	466					cell adhesion	integral to membrane	hyaluronic acid binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						ACTGGTACTTCGTCAAGTCAC	0.507000													18	33					0	0	1	0	0
IZUMO2	126123	broad.mit.edu	37	19	50657963	50657963	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50657963C>T	ENST00000293405.3	-	6	517	c.517G>A	c.(517-519)Gcc>Acc	p.A173T		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	173						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						TACTGCAGGGCCACGCGGGGT	0.607000													10	54					0	0	1	0	0
PCDHA3	0	broad.mit.edu	37	5	140181323	140181323	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140181323G>A	ENST00000522353.2	+	1	541	c.541G>A	c.(541-543)Gac>Aac	p.D181N	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.D181N|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTACCTTGGACGTTAAAAG	0.388000													14	35					0	0	1	0	0
TRAF3IP2	10758	broad.mit.edu	37	6	111896846	111896846	+	Splice_Site	SNP	G	G	A	rs147420020		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:111896846G>A	ENST00000368761.5	-	4	1679	c.1201_splice	c.e4+1	p.R401_splice	TRAF3IP2-AS1_ENST00000606892.1_RNA|TRAF3IP2_ENST00000359831.4_Splice_Site_p.R401_splice|TRAF3IP2-AS1_ENST00000449449.2_RNA|TRAF3IP2-AS1_ENST00000607066.1_RNA|TRAF3IP2-AS1_ENST00000440395.1_RNA|TRAF3IP2-AS1_ENST00000532353.1_RNA|TRAF3IP2_ENST00000340026.6_Splice_Site_p.R410_splice|TRAF3IP2-AS1_ENST00000442928.2_RNA|TRAF3IP2-AS1_ENST00000438298.2_RNA|TRAF3IP2-AS1_ENST00000456352.2_RNA|TRAF3IP2_ENST00000392556.4_5'UTR	NM_001164281.2|NM_147686.3	NP_001157753.1|NP_679211.2	O43734	CIKS_HUMAN	TRAF3 interacting protein 2	410					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	18		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		AACAACTTACGCAATTCTTCT	0.493000													17	34					0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53514641	53514641	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53514641C>T	ENST00000301466.3	+	11	1171	c.1111C>T	c.(1111-1113)Cga>Tga	p.R371*		NM_003578.3	NP_003569.1	O75908	SOAT2_HUMAN	sterol O-acyltransferase 2	371					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			endometrium(5)|kidney(3)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	18						CGAGATGCTACGATTTGGAGA	0.567000													41	55					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534270	92534270	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:92534270C>T	ENST00000298047.6	+	9	8108	c.8091C>T	c.(8089-8091)caC>caT	p.H2697H	FAT3_ENST00000409404.2_Silent_p.H2697H|FAT3_ENST00000525166.1_Silent_p.H2547H			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2697	Cadherin 24.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.H2697Q(4)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCTATATCCACGTCTTGCCCC	0.458000										TCGA Ovarian(4;0.039)			10	20					0	0	1	0	0
RRH	10692	broad.mit.edu	37	4	110758737	110758737	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:110758737G>A	ENST00000317735.4	+	5	730	c.696G>A	c.(694-696)tgG>tgA	p.W232*		NM_006583.2	NP_006574.1	O14718	OPSX_HUMAN	retinal pigment epithelium-derived rhodopsin homolog	232					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	12		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		ACAGAGACTGGTCAGATCAGA	0.423000													7	20					0	0	1	0	0
PCCA	5095	broad.mit.edu	37	13	101077940	101077940	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:101077940G>A	ENST00000376285.1	+	20	1838	c.1800G>A	c.(1798-1800)tcG>tcA	p.S600S	PCCA_ENST00000376279.3_Silent_p.S600S|PCCA_ENST00000376286.4_Silent_p.S574S	NM_000282.3	NP_000273.2	P05165	PCCA_HUMAN	propionyl CoA carboxylase, alpha polypeptide	600					fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity	p.S600S(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|prostate(1)|skin(2)	26	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	ACCTGGCTTCGCCCTTATTGT	0.473000													6	31					0	0	1	0	0
NT5C2	22978	broad.mit.edu	37	10	104850752	104850752	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:104850752G>A	ENST00000343289.5	-	16	1300	c.1211_splice	c.e16-1	p.H405_splice	NT5C2_ENST00000423468.2_Splice_Site_p.H376_splice|NT5C2_ENST00000369857.4_5'UTR|NT5C2_ENST00000404739.3_Splice_Site_p.H405_splice	NM_001134373.2|NM_012229.4	NP_001127845.1|NP_036361.1	P49902	5NTC_HUMAN	5'-nucleotidase, cytosolic II	405					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|metal ion binding|nucleotide binding|protein binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|urinary_tract(1)	16		all_hematologic(284;0.176)|Colorectal(252;0.178)		Epithelial(162;1.33e-08)|all cancers(201;1.04e-07)|BRCA - Breast invasive adenocarcinoma(275;0.159)	Adenosine triphosphate(DB00171)|Ribavirin(DB00811)	CTGTCAAGATGCCTAAAGATA	0.408000													6	38					0	0	1	0	0
TLX2	3196	broad.mit.edu	37	2	74742790	74742790	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74742790G>A	ENST00000233638.7	+	2	754	c.431G>A	c.(430-432)cGc>cAc	p.R144H		NM_016170.4	NP_057254.1	O43763	TLX2_HUMAN	T-cell leukemia homeobox 2	144						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|ovary(1)	2						GGGACGCGCCGCATAGGCCAC	0.667000													8	58					0	0	1	0	0
TRIM49	57093	broad.mit.edu	37	11	89531657	89531657	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:89531657G>A	ENST00000329758.1	-	8	1328	c.1000C>T	c.(1000-1002)Cag>Tag	p.Q334*	TRIM49_ENST00000532501.2_Nonsense_Mutation_p.Q257*	NM_020358.2	NP_065091.1	P0CI25	TRI49_HUMAN	tripartite motif containing 49	334	B30.2/SPRY.					intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(14)|prostate(1)|skin(2)|stomach(1)	27		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GTGAAAGTCTGAACACCCCAT	0.423000													4	51					0	0	1	0	0
STRN	6801	broad.mit.edu	37	2	37076751	37076751	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:37076751G>A	ENST00000263918.4	-	18	2199	c.2191C>T	c.(2191-2193)Cgt>Tgt	p.R731C	STRN_ENST00000379213.2_Missense_Mutation_p.R682C	NM_003162.3	NP_003153.2	O43815	STRN_HUMAN	striatin, calmodulin binding protein	731					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TTCCATAAACGTATTGAACAG	0.313000													7	29					0	0	1	0	0
PIK3R5	23533	broad.mit.edu	37	17	8792166	8792166	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:8792166T>C	ENST00000447110.1	-	10	1062	c.938A>G	c.(937-939)cAg>cGg	p.Q313R	PIK3R5_ENST00000581552.1_Missense_Mutation_p.Q313R|PIK3R5_ENST00000584803.1_Missense_Mutation_p.Q313R	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	313				DILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGH CAERDSLLSTSSLASHDSTLSLASSQASG -> GNIEGDPG PRRPDSAGLASLQTSCRKSCSRNRSYSSQGSWEMMKRRERR RRRWRRTWKLTGTVPREIPCS (in Ref. 6; AAW63121).	platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						GATCCCTGGCTGGAGTAGCTC	0.587000													6	9					0	0	1	0	0
CUL4A	8451	broad.mit.edu	37	13	113897425	113897425	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:113897425C>A	ENST00000451881.1	+	11	1128	c.879C>A	c.(877-879)tcC>tcA	p.S293S	CUL4A_ENST00000375440.4_Silent_p.S393S|CUL4A_ENST00000375441.3_Silent_p.S293S|CUL4A_ENST00000326335.4_Silent_p.S293S	NM_001278513.1|NM_003589.2	NP_001265442.1|NP_003580.1	Q13619	CUL4A_HUMAN	cullin 4A	393					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|skin(1)	17	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			TGAAGGAGTCCTTTGAGACGT	0.448000													6	102					0.00116845	0.0011864	1	1	0
TP53BP2	7159	broad.mit.edu	37	1	223991909	223991909	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:223991909C>T	ENST00000391878.2	-	7	997	c.229G>A	c.(229-231)Gtg>Atg	p.V77M	TP53BP2_ENST00000343537.7_Missense_Mutation_p.V206M	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	200					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		TTCTGTTCCACGTGGCCTTTA	0.378000													51	101					0	0	1	0	0
PDGFC	56034	broad.mit.edu	37	4	157771538	157771538	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:157771538A>G	ENST00000502773.1	-	2	639	c.149T>C	c.(148-150)aTt>aCt	p.I50T	PDGFC_ENST00000422544.2_Missense_Mutation_p.I50T|PDGFC_ENST00000541126.1_Intron	NM_016205.2	NP_057289.1	Q9NRA1	PDGFC_HUMAN	platelet derived growth factor C	50	CUB.				central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		AGACACAGTAATAATTCTCTC	0.343000													16	32					0	0	1	0	0
TUBB4A	10382	broad.mit.edu	37	19	6495417	6495417	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6495417C>T	ENST00000264071.2	-	4	1464	c.1093G>A	c.(1093-1095)Gcg>Acg	p.A365T	TUBB4A_ENST00000540257.1_Missense_Mutation_p.A365T			P04350	TBB4_HUMAN	tubulin, beta 4A class IVa	365			A -> V (in dbSNP:rs1053267).		'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity										ATGAAGGTCGCGGCCATCTTC	0.617000													52	92					0	0	1	0	0
MFAP3	4238	broad.mit.edu	37	5	153433126	153433126	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:153433126T>C	ENST00000436816.1	+	3	1161	c.942T>C	c.(940-942)gtT>gtC	p.V314V	MFAP3_ENST00000322602.5_Silent_p.V314V|MFAP3_ENST00000439768.2_Silent_p.V168V	NM_001242336.1|NM_005927.4	NP_001229265.1|NP_005918.1	P55082	MFAP3_HUMAN	microfibrillar-associated protein 3	314						integral to membrane|plasma membrane				breast(1)|kidney(2)|large_intestine(1)|lung(2)|pancreas(1)	7	Renal(175;0.00488)	Lung NSC(249;0.00145)|all_lung(500;0.00226)|all_neural(177;0.122)|Breast(839;0.14)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;9.69e-06)|GBM - Glioblastoma multiforme(465;0.0201)		AAATAGCAGTTCAGGTTTCTG	0.448000													8	53					0	0	1	0	0
GNA13	10672	broad.mit.edu	37	17	63010442	63010442	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:63010442C>T	ENST00000439174.2	-	4	1312	c.1067G>A	c.(1066-1068)cGc>cAc	p.R356H	GNA13_ENST00000541118.1_Missense_Mutation_p.R261H	NM_006572.4	NP_006563.2	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein), alpha 13	356					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(14)|kidney(2)|large_intestine(4)|lung(6)|urinary_tract(1)	34						GAAAACAAGGCGGATGTTCTC	0.443000													33	30					0	0	1	0	0
BAIAP2	10458	broad.mit.edu	37	17	79077815	79077815	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79077815T>C	ENST00000321300.6	+	9	1066	c.973T>C	c.(973-975)Tct>Cct	p.S325P	BAIAP2_ENST00000575245.1_Missense_Mutation_p.S358P|BAIAP2_ENST00000435091.3_Missense_Mutation_p.S325P|BAIAP2_ENST00000416299.2_Missense_Mutation_p.S188P|BAIAP2_ENST00000392411.3_Missense_Mutation_p.S247P|BAIAP2_ENST00000575712.1_Missense_Mutation_p.S325P|BAIAP2_ENST00000321280.7_Missense_Mutation_p.S325P|BAIAP2_ENST00000428708.2_Missense_Mutation_p.S325P	NM_001144888.1|NM_017451.2	NP_001138360.1|NP_059345.1	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2	325					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)	18	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CAAATCCCTGTCTCCTCCGCA	0.617000													23	34					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16893673	16893673	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16893673C>T	ENST00000430580.2	-	25	3727		c.e25+1		NBPF1_ENST00000420031.2_Splice_Site|NBPF1_ENST00000432949.1_Splice_Site	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AAGGTACTCACCATCCATGTC	0.468000													50	2266					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134073055	134073055	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:134073055G>A	ENST00000264360.4	+	1	2586	c.1760G>A	c.(1759-1761)cGt>cAt	p.R587H		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	587	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ACTCCAGCGCGTGAGGTGCTG	0.662000													15	18					0	0	1	0	0
USE1	55850	broad.mit.edu	37	19	17329200	17329200	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17329200C>T	ENST00000445667.2	+	6	482	c.422_splice	c.e6+1	p.T141_splice	USE1_ENST00000595101.1_3'UTR|USE1_ENST00000596136.1_Splice_Site_p.T141_splice|USE1_ENST00000379776.4_Splice_Site_p.T141_splice|USE1_ENST00000263897.5_Splice_Site_p.T141_splice			Q9NZ43	USE1_HUMAN	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	141					lysosomal transport|protein catabolic process|protein transport|secretion by cell|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(2)|endometrium(1)|lung(3)	6						AGGAAGAGAACGTGAGTGTCT	0.582000													12	14					0	0	1	0	0
PDE10A	10846	broad.mit.edu	37	6	165749679	165749679	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:165749679C>T	ENST00000366882.1	-	22	2324	c.2170G>A	c.(2170-2172)Gcc>Acc	p.A724T	PDE10A_ENST00000539869.2_Missense_Mutation_p.A734T|PDE10A_ENST00000354448.4_Missense_Mutation_p.A724T			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	724					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CAGGGAATGGCCACGGCATTG	0.443000													7	23					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151879308	151879308	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:151879308C>T	ENST00000355193.2	-	36	5855	c.5637G>A	c.(5635-5637)ccG>ccA	p.P1879P	KMT2C_ENST00000262189.6_Silent_p.P1879P					lysine (K)-specific methyltransferase 2C																		AAAACACTTGCGGTGAGGGTG	0.537000													27	32					0	0	1	0	0
HPSE	10855	broad.mit.edu	37	4	84240569	84240569	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:84240569C>T	ENST00000405413.2	-	4	563	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	HPSE_ENST00000512196.1_Missense_Mutation_p.E143K|HPSE_ENST00000311412.5_Missense_Mutation_p.E143K|HPSE_ENST00000513463.1_Missense_Mutation_p.E143K	NM_006665.5	NP_006656.2	Q9Y251	HPSE_HUMAN	heparanase	143					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	TAGGGCCATTCCAACCGTAAC	0.443000													27	46					0	0	1	0	0
PRR22	163154	broad.mit.edu	37	19	5784044	5784044	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:5784044C>T	ENST00000419421.2	-	3	318	c.214G>A	c.(214-216)Ggg>Agg	p.G72R	CTB-54O9.9_ENST00000586012.1_3'UTR	NM_001134316.1	NP_001127788.1	Q8IZ63	PRR22_HUMAN	proline rich 22	70										endometrium(2)|large_intestine(1)|prostate(1)|urinary_tract(1)	5						AAGAAGCACCCGCATGGGGCC	0.677000													19	23					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179297355	179297355	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:179297355G>T	ENST00000356834.3	-	16	2662	c.2625C>A	c.(2623-2625)gcC>gcA	p.A875A	TBC1D9B_ENST00000444477.2_Silent_p.A33A|TBC1D9B_ENST00000355235.3_Silent_p.A875A|TBC1D9B_ENST00000519746.1_Silent_p.A51A	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	875						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGAGCCACAGGCCCAGGGTG	0.612000													25	64					2.79863e-10	2.98826e-10	1	1	0
C6orf118	168090	broad.mit.edu	37	6	165711580	165711580	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:165711580G>A	ENST00000543069.1	-	5	1216	c.635C>T	c.(634-636)gCt>gTt	p.A212V	C6orf118_ENST00000230301.8_Missense_Mutation_p.A316V			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	316										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CTTGAGTTGAGCCAGAAGAGC	0.572000													10	22					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124383983	124383983	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:124383983G>A	ENST00000287394.5	-	4	570	c.463C>T	c.(463-465)Cgt>Tgt	p.R155C	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CAACTTCGACGCACTTCAACA	0.368000													11	24					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43801572	43801572	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:43801572G>A	ENST00000403856.1	-	12	1779	c.1632C>T	c.(1630-1632)taC>taT	p.Y544Y	THADA_ENST00000402360.2_Silent_p.Y544Y|THADA_ENST00000405006.4_Silent_p.Y544Y|THADA_ENST00000330266.7_Silent_p.Y254Y|THADA_ENST00000415080.2_Silent_p.Y254Y|THADA_ENST00000405975.2_Silent_p.Y544Y|THADA_ENST00000404790.1_Silent_p.Y544Y			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	544							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AATCAATCACGTAAGATTTTT	0.378000													7	10					0	0	1	0	0
ETF1	2107	broad.mit.edu	37	5	137848593	137848593	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:137848593G>A	ENST00000499810.2	-	6	941	c.493C>T	c.(493-495)Cga>Tga	p.R165*	ETF1_ENST00000360541.5_Nonsense_Mutation_p.R198*|ETF1_ENST00000503014.1_Nonsense_Mutation_p.R184*			P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	198					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TAGTTATGTCGCTTTTCCATT	0.433000													34	28					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7618675	7618675	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:7618675G>A	ENST00000256861.6	-	10	1797	c.1719C>T	c.(1717-1719)atC>atT	p.I573I	ITIH5_ENST00000446830.2_Silent_p.I355I|ITIH5_ENST00000397145.2_Silent_p.I573I|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397146.2_Silent_p.I573I|ITIH5_ENST00000298441.6_Silent_p.I359I	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	573					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						AGAGACGCTCGATGTGGTTGG	0.622000													5	24					0	0	1	0	0
JAK1	3716	broad.mit.edu	37	1	65303726	65303726	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:65303726A>G	ENST00000342505.4	-	22	3277	c.3029T>C	c.(3028-3030)cTt>cCt	p.L1010P		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	1010	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		ACTCTCAACAAGGACATTTCT	0.453000			Mis		ALL								16	18					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23065690	23065690	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:23065690C>A	ENST00000246006.4	-	1	1287	c.1140G>T	c.(1138-1140)gaG>gaT	p.E380D		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	380	EGF-like 3; calcium-binding (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GACAGGCCCCCTCTCCAGGAC	0.632000													12	18					9.31168e-06	9.64599e-06	1	1	0
IGSF3	3321	broad.mit.edu	37	1	117156481	117156481	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:117156481G>A	ENST00000369486.3	-	4	1503	c.738C>T	c.(736-738)tgC>tgT	p.C246C	IGSF3_ENST00000369483.1_Silent_p.C246C|IGSF3_ENST00000318837.6_Silent_p.C246C	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	246	Ig-like C2-type 2.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CGGCGGCCTCGCAGTAGAATT	0.632000													10	13					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44796659	44796659	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44796659G>A	ENST00000309315.4	+	4	402	c.279G>A	c.(277-279)gcG>gcA	p.A93A	ZMIZ2_ENST00000433667.1_Silent_p.A61A|ZMIZ2_ENST00000441627.1_Silent_p.A93A|ZMIZ2_ENST00000413916.1_Silent_p.A61A|ZMIZ2_ENST00000265346.7_Silent_p.A93A	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	93	Gly-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding	p.A93A(1)		breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GACAGCAGGCGTTTGCTGAAG	0.677000													6	35					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86266404	86266404	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:86266404C>T	ENST00000394518.2	+	26	6693	c.6598C>T	c.(6598-6600)Cgt>Tgt	p.R2200C	AKAP13_ENST00000361243.2_Missense_Mutation_p.R2204C|AKAP13_ENST00000394510.2_Missense_Mutation_p.R445C|AKAP13_ENST00000560579.1_3'UTR	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2200	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						AAAGAAAGTGCGTCTCAATGA	0.428000													15	24					0	0	1	0	0
VNN2	8875	broad.mit.edu	37	6	133078827	133078827	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:133078827T>C	ENST00000326499.6	-	1	320	c.196A>G	c.(196-198)Aag>Gag	p.K66E	VNN2_ENST00000526192.1_5'UTR|VNN2_ENST00000525289.1_Missense_Mutation_p.K66E|VNN2_ENST00000525270.1_Missense_Mutation_p.K13E	NM_004665.2	NP_004656.2	O95498	VNN2_HUMAN	vanin 2	66	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		GCTGCCTGCTTGATCGCTGTC	0.438000													34	48					0	0	1	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130376384	130376384	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:130376384G>A	ENST00000529410.1	+	10	1130	c.651G>A	c.(649-651)tcG>tcA	p.S217S	L3MBTL3_ENST00000368139.2_Silent_p.S192S|L3MBTL3_ENST00000368136.2_Silent_p.S217S|L3MBTL3_ENST00000361794.2_Silent_p.S217S|L3MBTL3_ENST00000533560.1_Silent_p.S192S|L3MBTL3_ENST00000526019.1_Silent_p.S192S			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	217					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.S217S(1)		cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		GAGGGGATTCGGCTGTACTAA	0.393000													11	8					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017486	93017486	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:93017486C>T	ENST00000523629.1	-	6	1052	c.598G>A	c.(598-600)Gca>Aca	p.A200T	RUNX1T1_ENST00000436581.2_Missense_Mutation_p.A211T|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.A200T|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.A163T|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.A173T|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.A163T|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.A163T|RUNX1T1_ENST00000521553.1_Missense_Mutation_p.A163T|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.A173T	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	200	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A211S(1)|p.A200S(1)|p.A163S(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GCCAGTCTTGCGCAGTGGAGG	0.562000													14	19					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97463370	97463370	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:97463370G>A	ENST00000377075.2	+	3	1765	c.1667G>A	c.(1666-1668)cGc>cAc	p.R556H	CNNM4_ENST00000540067.1_Missense_Mutation_p.R43H|CNNM4_ENST00000496186.1_3'UTR	NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	556					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						GCCGCTCATCGCTTCCTAGCC	0.572000													9	18					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160098444	160098444	+	Silent	SNP	G	G	A	rs142140032		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160098444G>A	ENST00000361216.3	+	9	1109	c.1020G>A	c.(1018-1020)gtG>gtA	p.V340V	ATP1A2_ENST00000392233.3_Silent_p.V340V|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	340					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TCTACCAGGTGTGCCTGACCC	0.572000													10	51					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52428607	52428607	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52428607T>C	ENST00000420323.2	+	67	11014	c.10753T>C	c.(10753-10755)Tcc>Ccc	p.S3585P		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3650					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AACCTTTTCCTCCTTCTCTTC	0.577000													6	34					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27349345	27349345	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:27349345G>T	ENST00000376087.4	-	15	1658	c.1491_splice	c.e15-1	p.P498_splice	ANKRD26_ENST00000436985.2_Splice_Site_p.P514_splice	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	498						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						TTCAATGGTAGGCTGAATGGG	0.269000													39	83					1.49673e-21	1.66298e-21	1	1	0
PLEKHM1	9842	broad.mit.edu	37	17	43531226	43531226	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:43531226G>A	ENST00000430334.3	-	7	2125	c.1992C>T	c.(1990-1992)ccC>ccT	p.P664P	AC091132.1_ENST00000433601.1_RNA|PLEKHM1_ENST00000421073.2_Silent_p.P575P	NM_014798.2	NP_055613.1	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 1	664					intracellular signal transduction	cytoplasm	metal ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26	Renal(3;0.0405)					GGAGGGCCGCGGGCTCCGAGA	0.637000													9	39					0	0	1	0	0
TMEM25	84866	broad.mit.edu	37	11	118403905	118403905	+	Missense_Mutation	SNP	C	C	T	rs140899282		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118403905C>T	ENST00000524725.1	+	3	1068	c.656C>T	c.(655-657)gCg>gTg	p.A219V	TMEM25_ENST00000529001.1_3'UTR|TMEM25_ENST00000442938.2_Missense_Mutation_p.A219V|TMEM25_ENST00000533102.1_Missense_Mutation_p.A219V|TMEM25_ENST00000411589.2_Missense_Mutation_p.A219V|TMEM25_ENST00000544878.1_Intron|TMEM25_ENST00000313236.5_Missense_Mutation_p.A219V|TMEM25_ENST00000359862.4_Missense_Mutation_p.A219V|TMEM25_ENST00000354064.7_Missense_Mutation_p.A115V|TMEM25_ENST00000354284.4_Missense_Mutation_p.A219V			Q86YD3	TMM25_HUMAN	transmembrane protein 25	219						extracellular region|integral to membrane|plasma membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|stomach(1)	13	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		GTCACCAGTGCGTCGCTTCCA	0.617000													3	12					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823608	38823608	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38823608C>T	ENST00000303592.3	-	2	788	c.530G>A	c.(529-531)cGg>cAg	p.R177Q		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	177					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					CTTCTTGGGCCGCGCCATCTT	0.642000													11	18					0	0	1	0	0
RARS2	57038	broad.mit.edu	37	6	88240652	88240652	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:88240652T>C	ENST00000369536.5	-	9	666	c.621A>G	c.(619-621)gtA>gtG	p.V207V		NM_020320.3	NP_064716.2	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	207					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		TATTAACTTGTACATAAACCT	0.363000													4	44					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132207163	132207163	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:132207163A>G	ENST00000260818.6	+	30	3537	c.3289A>G	c.(3289-3291)Atc>Gtc	p.I1097V		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1097				I -> T (in Ref. 6; BAC86133).			heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						CTTTGACCCTATCCTTGTTGA	0.338000													18	40					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114069597	114069597	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:114069597C>A	ENST00000462705.1	-	11	1930	c.1109G>T	c.(1108-1110)aGc>aTc	p.S370I	ZBTB20_ENST00000357258.3_Missense_Mutation_p.S370I|ZBTB20_ENST00000464560.1_Missense_Mutation_p.S370I|ZBTB20_ENST00000481632.1_Missense_Mutation_p.S370I|ZBTB20_ENST00000471418.1_Missense_Mutation_p.S370I|ZBTB20_ENST00000474710.1_Missense_Mutation_p.S443I|ZBTB20_ENST00000393785.2_Missense_Mutation_p.S370I	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	443					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GATAACAGTGCTGTCCATCTC	0.567000													31	57					5.77227e-19	6.37883e-19	1	1	0
API5	8539	broad.mit.edu	37	11	43357418	43357418	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:43357418G>T	ENST00000378852.3	+	13	1491	c.1366G>T	c.(1366-1368)Gcc>Tcc	p.A456S	API5_ENST00000534600.1_Missense_Mutation_p.A456S|API5_ENST00000420461.2_Missense_Mutation_p.A402S|API5_ENST00000534695.1_Intron|API5_ENST00000529334.1_3'UTR|API5_ENST00000455725.2_Missense_Mutation_p.A445S|API5_ENST00000531273.1_Missense_Mutation_p.A456S|RP11-484D2.2_ENST00000526220.1_RNA	NM_001142930.1|NM_006595.3	NP_001136402.1|NP_006586.1	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5	456					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20						GCAAAAGAGAGCCAGTGAAGA	0.373000													29	28					7.26314e-15	7.9373e-15	1	1	0
SZT2	23334	broad.mit.edu	37	1	43906208	43906208	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43906208C>A	ENST00000562955.1	+	51	7124	c.7124C>A	c.(7123-7125)cCt>cAt	p.P2375H	SZT2_ENST00000372442.1_Missense_Mutation_p.P1533H	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2432						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CCTGGGGAGCCTGTGACTCCA	0.577000													25	30					2.21704e-12	2.3975e-12	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152477120	152477120	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152477120G>T	ENST00000367255.5	-	132	24504	c.23903C>A	c.(23902-23904)tCt>tAt	p.S7968Y	SYNE1_ENST00000354674.4_Missense_Mutation_p.S123Y|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000539504.1_Missense_Mutation_p.S123Y|SYNE1_ENST00000448038.1_Missense_Mutation_p.S7897Y|SYNE1_ENST00000356820.4_Missense_Mutation_p.S2492Y|SYNE1_ENST00000341594.5_Missense_Mutation_p.S7580Y|SYNE1_ENST00000423061.1_Missense_Mutation_p.S7897Y|SYNE1_ENST00000265368.4_Missense_Mutation_p.S7968Y	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7968					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGCTGTATAGAGTCACACTC	0.522000										HNSCC(10;0.0054)			10	56					0.000673444	0.000685014	1	1	0
ATP10A	57194	broad.mit.edu	37	15	25981214	25981214	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:25981214A>G	ENST00000356865.6	-	3	840	c.729T>C	c.(727-729)ttT>ttC	p.F243F		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	243					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TGCAGCCGCGAAACCTACTCA	0.453000													19	22					0	0	1	0	0
DBC1	0	broad.mit.edu	37	9	121930403	121930403	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:121930403G>A	ENST00000265922.3	-	8	1706	c.1245C>T	c.(1243-1245)tgC>tgT	p.C415C	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		415					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						TGCTGCCGTGGCACACGCAGC	0.612000													8	16					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1993988	1993988	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:1993988G>A	ENST00000382722.5	-	11	1580	c.1218C>T	c.(1216-1218)ggC>ggT	p.G406G	CACNA2D4_ENST00000585732.1_Silent_p.G322G|CACNA2D4_ENST00000587995.1_Silent_p.G406G|CACNA2D4_ENST00000588077.1_Silent_p.G342G|CACNA2D4_ENST00000585708.1_Silent_p.G342G|CACNA2D4_ENST00000586184.1_Silent_p.G406G	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	406	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CCTCCACGGCGCCGTCGCTGA	0.577000													11	14					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34060621	34060621	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:34060621C>T	ENST00000397527.1	+	12	1894	c.1174C>T	c.(1174-1176)Cgt>Tgt	p.R392C	CEP250_ENST00000342580.4_Missense_Mutation_p.R392C	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	392					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TACTCTGGTGCGTTCAGTGCT	0.512000													29	58					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111965561	111965561	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:111965561C>T	ENST00000369732.3	-	6	651	c.596G>A	c.(595-597)cGc>cAc	p.R199H	OVGP1_ENST00000481495.1_5'UTR|OVGP1_ENST00000540696.1_Missense_Mutation_p.R139H	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	199					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TCCTAGAAAGCGCACATCATA	0.562000													55	130					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30887978	30887978	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:30887978A>G	ENST00000251071.5	-	4	1483	c.733T>C	c.(733-735)Tat>Cat	p.Y245H	CAPRIN2_ENST00000538387.1_5'UTR|CAPRIN2_ENST00000395805.2_Missense_Mutation_p.Y245H|CAPRIN2_ENST00000417045.1_Missense_Mutation_p.Y245H|CAPRIN2_ENST00000298892.5_Missense_Mutation_p.Y245H|CAPRIN2_ENST00000308433.5_5'UTR	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	245					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GAAGGCAAATACACTGCACCA	0.378000													14	188					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4027606	4027606	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4027606G>A	ENST00000294016.3	-	9	3243	c.2705C>T	c.(2704-2706)gCg>gTg	p.A902V		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	902					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GGCAATCAGCGCGGCCGAGCC	0.662000													4	9					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100346235	100346235	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:100346235C>T	ENST00000294724.4	+	14	2261	c.1783C>T	c.(1783-1785)Cga>Tga	p.R595*	AGL_ENST00000370161.2_Nonsense_Mutation_p.R579*|AGL_ENST00000361302.3_Nonsense_Mutation_p.R579*|AGL_ENST00000361915.3_Nonsense_Mutation_p.R595*|AGL_ENST00000370165.3_Nonsense_Mutation_p.R595*|AGL_ENST00000361522.4_Nonsense_Mutation_p.R578*|AGL_ENST00000370163.3_Nonsense_Mutation_p.R595*	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	595					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding	p.R595R(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		ATTAGTTTACCGATATGGAGG	0.398000													49	91					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52433005	52433005	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52433005G>A	ENST00000420323.2	+	76	12490	c.12229G>A	c.(12229-12231)Gcc>Acc	p.A4077T		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	4142					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCTCTGGAGTGCCAAGGCCTA	0.572000													4	53					0	0	1	0	0
MDFIC	29969	broad.mit.edu	37	7	114655765	114655765	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:114655765G>T	ENST00000393486.1	+	5	1107	c.517G>T	c.(517-519)Gct>Tct	p.A173S	MDFIC_ENST00000257724.3_Missense_Mutation_p.A282S	NM_001166345.1|NM_199072.4	NP_001159817.1|NP_951038.1	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing	173	Cys-rich.				activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	cyclin binding|Tat protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	8						CTGTATCCTGGCTTGCTTGTT	0.453000													80	135					2.09077e-21	2.32225e-21	1	1	0
DENND1A	57706	broad.mit.edu	37	9	126144481	126144481	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:126144481G>A	ENST00000373624.2	-	22	2461	c.2260C>T	c.(2260-2262)Cct>Tct	p.P754S	DENND1A_ENST00000542603.1_Missense_Mutation_p.P539S|DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000394219.3_Missense_Mutation_p.P765S	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	754	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						ACAACACCAGGCAGGAGCCCT	0.711000													7	9					0	0	1	0	0
GPC1	2817	broad.mit.edu	37	2	241401798	241401798	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:241401798G>A	ENST00000264039.2	+	3	764	c.516G>A	c.(514-516)gaG>gaA	p.E172E		NM_002081.2	NP_002072.2	P35052	GPC1_HUMAN	glypican 1	172					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	9		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		GCCTGCTCGAGCGCCTCTTCA	0.692000													4	6					0	0	1	0	0
COLGALT1	79709	broad.mit.edu	37	19	17671207	17671207	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17671207A>G	ENST00000252599.4	+	3	542	c.422A>G	c.(421-423)gAg>gGg	p.E141G		NM_024656.2	NP_078932.2			collagen beta(1-O)galactosyltransferase 1																		TCACGCTACGAGCATGTCATG	0.552000													19	21					0	0	1	0	0
TIGD2	166815	broad.mit.edu	37	4	90034372	90034372	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:90034372A>G	ENST00000317005.2	+	1	405	c.247A>G	c.(247-249)Atg>Gtg	p.M83V		NM_145715.2	NP_663761.1	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	83	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	14		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		TGATAGAGTTATGATAGAGTG	0.388000													38	56					0	0	1	0	0
EIF4B	1975	broad.mit.edu	37	12	53421650	53421650	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53421650G>A	ENST00000262056.9	+	7	1078	c.752G>A	c.(751-753)cGa>cAa	p.R251Q	EIF4B_ENST00000420463.3_Missense_Mutation_p.R251Q|RP11-983P16.4_ENST00000552905.1_RNA|EIF4B_ENST00000416762.3_Missense_Mutation_p.R212Q	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	251	Arg-rich.|Asp-rich.				insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						GATATGGATCGATATGGTGGC	0.483000													16	21					0	0	1	0	0
C6orf222	389384	broad.mit.edu	37	6	36298070	36298070	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:36298070G>A	ENST00000437635.2	-	2	575	c.398C>T	c.(397-399)cCg>cTg	p.P133L		NM_001010903.4	NP_001010903.3	P0C671	CF222_HUMAN	chromosome 6 open reading frame 222	133										breast(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(4)|urinary_tract(4)	26						CAGGGGCTCCGGATGCTGGGA	0.617000													32	34					0	0	1	0	0
TTC30B	150737	broad.mit.edu	37	2	178415725	178415725	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:178415725G>T	ENST00000408939.2	-	1	2017	c.1767C>A	c.(1765-1767)tgC>tgA	p.C589*		NM_152517.2	NP_689730.2	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	589					cell projection organization	cilium	binding			cervix(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			AGGACAGGAAGCATCTTTTGG	0.378000													25	132					5.61819e-17	6.17723e-17	1	1	0
P2RY2	5029	broad.mit.edu	37	11	72946149	72946149	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:72946149C>A	ENST00000311131.2	+	3	1412	c.945C>A	c.(943-945)cgC>cgA	p.R315R	P2RY2_ENST00000393597.2_Silent_p.R315R|P2RY2_ENST00000393596.2_Silent_p.R315R	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	315					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	GGCTCGTACGCTTTGCCCGAG	0.647000													9	10					5.4927e-09	5.81457e-09	1	1	0
ACOX2	8309	broad.mit.edu	37	3	58508282	58508282	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58508282C>T	ENST00000302819.5	-	12	1864	c.1573G>A	c.(1573-1575)Gga>Aga	p.G525R	ACOX2_ENST00000459701.2_Missense_Mutation_p.G511R|ACOX2_ENST00000481527.1_5'UTR	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	525					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		TGGTCAGCTCCGGATTGCGTC	0.517000													18	34					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585993	82585993	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:82585993T>C	ENST00000423517.2	-	5	4613	c.4276A>G	c.(4276-4278)Aca>Gca	p.T1426A	PCLO_ENST00000333891.8_Missense_Mutation_p.T1426A	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1357					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCAGCAAGTGTACTTGCTTGA	0.403000													23	17					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147380167	147380167	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:147380167C>T	ENST00000240986.4	+	2	138	c.85C>T	c.(85-87)Ctt>Ttt	p.L29F	GJA8_ENST00000369235.1_Missense_Mutation_p.L29F	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	29					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					GCTCACCGTGCTTTTCATCTT	0.582000													5	65					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28575164	28575164	+	Missense_Mutation	SNP	G	G	A	rs138950489		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:28575164G>A	ENST00000220562.4	+	3	2490	c.1588G>A	c.(1588-1590)Gtg>Atg	p.V530M	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Missense_Mutation_p.V146M	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	530						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TTTTAATACCGTGCTGGCTAT	0.577000													15	21					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57721655	57721655	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:57721655A>G	ENST00000269122.3	+	2	335	c.61A>G	c.(61-63)Aac>Gac	p.N21D	CLTC_ENST00000393043.1_Missense_Mutation_p.N21D|CLTC_ENST00000579456.1_Missense_Mutation_p.N21D	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	21	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					cctgggtatcaacccagcaaa	0.408000			T	"""ALK, TFE3"""	"""ALCL, renal """								44	5					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192225388	192225388	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:192225388G>A	ENST00000392318.3	+	8	841	c.594G>A	c.(592-594)caG>caA	p.Q198Q	MYO1B_ENST00000339514.4_Silent_p.Q198Q|MYO1B_ENST00000392316.1_Silent_p.Q198Q|MYO1B_ENST00000304164.4_Silent_p.Q198Q	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	198	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			TTGTTAAACAGCCAAGAGGTG	0.398000													52	94					0	0	1	0	0
MPRIP	23164	broad.mit.edu	37	17	17076038	17076038	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:17076038C>T	ENST00000395811.5	+	17	2427	c.2338C>T	c.(2338-2340)Cgg>Tgg	p.R780W	MPRIP_ENST00000395804.3_Missense_Mutation_p.R780W|RP11-45M22.3_ENST00000584203.1_RNA|MPRIP_ENST00000341712.4_Missense_Mutation_p.R780W|MPRIP_ENST00000444976.1_Missense_Mutation_p.R742W	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	780	Interaction with RHOA.					cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						GAACGCCCACCGGGAGGAAAT	0.652000													13	40					0	0	1	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117959424	117959424	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:117959424C>T	ENST00000310164.2	+	4	724	c.217C>T	c.(217-219)Cca>Tca	p.P73S		NM_173798.2	NP_776159.1	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	73					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	22						tggcgtcctgccagattggaa	0.552000													26	5					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	347148	347148	+	Silent	SNP	G	G	A	rs144376533	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:347148G>A	ENST00000343164.4	-	5	559	c.507C>T	c.(505-507)aaC>aaT	p.N169N	SLC6A13_ENST00000445055.2_Silent_p.N77N	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	169					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TCAGGGAGCCGTTGGTCTTCT	0.527000													18	25					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81934265	81934265	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:81934265G>T	ENST00000359376.3	+	14	1456	c.1242G>T	c.(1240-1242)caG>caT	p.Q414H		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	414	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						TGGAGCAACAGCGTCACATGG	0.632000													14	14					1.5842e-08	1.67426e-08	1	1	0
ZNF862	643641	broad.mit.edu	37	7	149558272	149558272	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149558272G>A	ENST00000223210.4	+	7	2268	c.2023G>A	c.(2023-2025)Gtt>Att	p.V675I		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	675					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						CGAGACCATCGTTTCTGCCCT	0.572000													8	15					0	0	1	0	0
ABHD1	84696	broad.mit.edu	37	2	27353417	27353417	+	Silent	SNP	C	C	T	rs112184308		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27353417C>T	ENST00000316470.4	+	9	1137	c.1023C>T	c.(1021-1023)gcC>gcT	p.A341A		NM_032604.3	NP_115993.3	Q96SE0	ABHD1_HUMAN	abhydrolase domain containing 1	341						integral to membrane	carboxylesterase activity			endometrium(1)|kidney(1)|lung(3)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCATACAGGCCGCCCAACACT	0.617000													22	63					0	0	1	0	0
CLPTM1L	81037	broad.mit.edu	37	5	1334415	1334415	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1334415C>T	ENST00000320895.5	-	7	1137	c.880G>A	c.(880-882)Gca>Aca	p.A294T	CLPTM1L_ENST00000507807.1_Missense_Mutation_p.A161T|CLPTM1L_ENST00000320927.6_Missense_Mutation_p.A294T	NM_030782.3	NP_110409.2	Q96KA5	CLP1L_HUMAN	CLPTM1-like	294					apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		TGGAACGCTGCGACAAAGAAG	0.552000													8	11					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594052	179594052	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179594052G>A	ENST00000589042.1	-	64	19055	c.18831C>T	c.(18829-18831)ggC>ggT	p.G6277G	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.G5960G|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Silent_p.G5033G|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5960	Ig-like 44.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCAGCTGCCGCCTTCATTGG	0.413000													35	64					0	0	1	0	0
CARS	833	broad.mit.edu	37	11	3062163	3062163	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3062163G>A	ENST00000397114.3	-	4	515	c.139C>T	c.(139-141)Cca>Tca	p.P47S	CARS-AS1_ENST00000499962.1_RNA|CARS_ENST00000397111.5_Missense_Mutation_p.P57S|CARS_ENST00000278224.9_Missense_Mutation_p.P57S|CARS_ENST00000401769.3_Missense_Mutation_p.P70S|CARS_ENST00000380525.4_Missense_Mutation_p.P140S			P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase	57					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|tRNA binding		CARS/ALK(5)	central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)	31		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	TAGACGGTTGGCCCACAGCAA	0.517000			T	ALK	ALCL								18	25					0	0	1	0	0
KLHL8	57563	broad.mit.edu	37	4	88085121	88085121	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:88085121C>T	ENST00000273963.5	-	9	1989	c.1648G>A	c.(1648-1650)Gca>Aca	p.A550T	KLHL8_ENST00000498875.2_Missense_Mutation_p.A474T|KLHL8_ENST00000425278.2_Missense_Mutation_p.A367T|KLHL8_ENST00000512111.1_Missense_Mutation_p.A550T|KLHL8_ENST00000545252.1_Missense_Mutation_p.A199T	NM_020803.3	NP_065854.3	Q9P2G9	KLHL8_HUMAN	kelch-like family member 8	550										breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)	17		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		ATCACTGTTGCGATTCCCACT	0.448000													37	37					0	0	1	0	0
INPP4B	8821	broad.mit.edu	37	4	142950019	142950019	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:142950019C>A	ENST00000513000.1	-	27	3124	c.2691G>T	c.(2689-2691)aaG>aaT	p.K897N	INPP4B_ENST00000262992.4_Missense_Mutation_p.K897N|INPP4B_ENST00000308502.4_Missense_Mutation_p.K897N|INPP4B_ENST00000508116.1_Missense_Mutation_p.K897N	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	897					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TGAAAGCATACTTTCTGCATT	0.393000													10	57					3.07112e-06	3.18879e-06	1	1	0
ARPP21	10777	broad.mit.edu	37	3	35778841	35778841	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:35778841C>A	ENST00000187397.4	+	16	2087	c.1631C>A	c.(1630-1632)cCt>cAt	p.P544H	ARPP21_ENST00000444190.1_Missense_Mutation_p.P490H|ARPP21_ENST00000337271.5_Missense_Mutation_p.P490H|ARPP21_ENST00000417925.1_Missense_Mutation_p.P510H|ARPP21_ENST00000458225.1_Missense_Mutation_p.P510H	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	544	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						ATGGCAGGCCCTCTGGTCACT	0.627000													6	10					0.0215528	0.0217053	1	1	0
GRM5	2915	broad.mit.edu	37	11	88300321	88300321	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:88300321G>A	ENST00000418177.2	-	8	2897	c.2530C>T	c.(2530-2532)Cgc>Tgc	p.R844C	GRM5_ENST00000455756.2_Missense_Mutation_p.R844C|GRM5_ENST00000305432.5_Missense_Mutation_p.R844C|GRM5_ENST00000305447.4_Missense_Mutation_p.R844C|GRM5_ENST00000393297.1_Missense_Mutation_p.R844C			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	844					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.R844S(2)		NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ACATGCATGCGCACCACGGTA	0.572000													27	42					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15971251	15971251	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:15971251C>T	ENST00000268712.3	-	32	4955	c.4698G>A	c.(4696-4698)acG>acA	p.T1566T	NCOR1_ENST00000395851.1_Silent_p.T1582T|NCOR1_ENST00000395857.3_Silent_p.T150T	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1566	Interaction with C1D (By similarity).|Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GATCCAAGTGCGTGGGCAGGT	0.512000													13	14					0	0	1	0	0
SDC4	6385	broad.mit.edu	37	20	43961680	43961680	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:43961680C>A	ENST00000372733.3	-	3	268	c.229G>T	c.(229-231)Gaa>Taa	p.E77*	SDC4_ENST00000537976.1_Nonsense_Mutation_p.E5*	NM_002999.3	NP_002990.2	P31431	SDC4_HUMAN	syndecan 4	77						extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity		SDC4/ROS1(7)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)	5		Myeloproliferative disorder(115;0.0122)				TGGACAACTTCAGGGCCGATC	0.502000			T	ROS1	NSCLC								8	34					0.0381472	0.0383569	1	1	0
PDE10A	10846	broad.mit.edu	37	6	165756961	165756961	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:165756961G>T	ENST00000366882.1	-	20	2140	c.1986C>A	c.(1984-1986)gcC>gcA	p.A662A	PDE10A_ENST00000539869.2_Silent_p.A672A|PDE10A_ENST00000354448.4_Silent_p.A662A			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	662					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	AAAGGTCACAGGCAGTCATCA	0.393000													26	35					3.65163e-15	3.99483e-15	1	1	0
ARHGAP44	9912	broad.mit.edu	37	17	12847434	12847434	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:12847434T>G	ENST00000379672.5	+	10	1082	c.782T>G	c.(781-783)cTc>cGc	p.L261R	ARHGAP44_ENST00000262444.9_Missense_Mutation_p.L261R|ARHGAP44_ENST00000340825.3_Missense_Mutation_p.L261R	NM_014859.4	NP_055674.4	Q17R89	RHG44_HUMAN	Rho GTPase activating protein 44	261	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|urinary_tract(1)	31						GAGGAGCACCTCACCATCAGC	0.597000													5	19					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58562618	58562618	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:58562618G>A	ENST00000348616.4	+	8	1248	c.948G>A	c.(946-948)ttG>ttA	p.L316L	CDH26_ENST00000244047.5_Silent_p.L316L	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	316	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TCAACATATTGCATGGCAATG	0.463000													27	40					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54359609	54359609	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:54359609G>A	ENST00000354646.2	-	2	936	c.498C>T	c.(496-498)gaC>gaT	p.D166D	WNK3_ENST00000375159.2_Silent_p.D166D|WNK3_ENST00000375169.3_Silent_p.D166D	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	166	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						ATGTTTCAGTGTCCAGTCCTT	0.408000													5	49					0	0	1	0	0
ZSCAN30	100101467	broad.mit.edu	37	18	32844160	32844160	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:32844160G>A	ENST00000420878.3	-	3	612	c.157C>T	c.(157-159)Cag>Tag	p.Q53*	ZSCAN30_ENST00000592278.1_Nonsense_Mutation_p.Q53*|ZSCAN30_ENST00000589178.1_Nonsense_Mutation_p.Q53*|ZNF397_ENST00000589420.1_Intron|ZSCAN30_ENST00000333206.5_Nonsense_Mutation_p.Q53*|ZSCAN30_ENST00000601405.1_Intron|ZSCAN30_ENST00000383091.2_Nonsense_Mutation_p.Q53*	NM_001166012.1	NP_001159484.1	Q86W11	ZSC30_HUMAN	zinc finger and SCAN domain containing 30	53	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(5)|lung(3)|urinary_tract(1)	9						TAACTAAACTGCCTGAACTTC	0.532000													8	35					0	0	1	0	0
LSM14B	149986	broad.mit.edu	37	20	60701437	60701437	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:60701437C>T	ENST00000253001.4	+	3	575	c.369C>T	c.(367-369)taC>taT	p.Y123Y	LSM14B_ENST00000279068.6_Silent_p.Y123Y|LSM14B_ENST00000370915.1_Silent_p.Y123Y			Q9BX40	LS14B_HUMAN	LSM14B, SCD6 homolog B (S. cerevisiae)	123					multicellular organismal development|regulation of translation	ribonucleoprotein complex				endometrium(3)|kidney(1)|lung(4)	8	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			TGGCGCCCTACGGCCCGCTGG	0.627000													8	18					0	0	1	0	0
ZNF418	147686	broad.mit.edu	37	19	58438297	58438297	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58438297G>A	ENST00000396147.1	-	4	1543	c.1252C>T	c.(1252-1254)Cga>Tga	p.R418*	ZNF418_ENST00000600989.1_Intron|ZNF418_ENST00000599852.1_Nonsense_Mutation_p.R333*|ZNF418_ENST00000425570.3_Nonsense_Mutation_p.R439*|ZNF418_ENST00000595830.1_Nonsense_Mutation_p.R418*	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		GTGTGACCTCGCTGATGGTTC	0.468000													47	95					0	0	1	0	0
TSSK6	83983	broad.mit.edu	37	19	19625556	19625556	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:19625556G>A	ENST00000360913.3	-	1	1282	c.681C>T	c.(679-681)ggC>ggT	p.G227G	TSSK6_ENST00000585580.3_Silent_p.G227G			Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6	227	Protein kinase.				multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	16						GATAGAGCACGCCGCGTTTCT	0.692000													9	51					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58275733	58275733	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:58275733G>A	ENST00000300896.4	-	27	3516	c.3322C>T	c.(3322-3324)Cca>Tca	p.P1108S	USP32_ENST00000592339.1_Missense_Mutation_p.P778S	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	1108					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ACAGTACATGGAACAATCAAT	0.458000													34	44					0	0	1	0	0
SNTA1	6640	broad.mit.edu	37	20	31998065	31998065	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31998065G>A	ENST00000217381.2	-	6	1384	c.1113C>T	c.(1111-1113)ggC>ggT	p.G371G		NM_003098.2	NP_003089.1	Q13424	SNTA1_HUMAN	syntrophin, alpha 1	371	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			breast(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|stomach(1)|urinary_tract(1)	13						CGTGACGCGTGCCCGTGCGCA	0.672000													9	7					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61601658	61601658	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61601658G>A	ENST00000583023.1	+	2	246	c.235G>A	c.(235-237)Gtg>Atg	p.V79M	KCNH6_ENST00000314672.5_Missense_Mutation_p.V79M|KCNH6_ENST00000581784.1_Missense_Mutation_p.V79M|KCNH6_ENST00000456941.2_Missense_Mutation_p.V79M|KCNH6_ENST00000580652.1_Missense_Mutation_p.V79M	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	79					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	AAGCAGCGCCGTGTCCCGCCT	0.627000													30	42					0	0	1	0	0
OR6C3	254786	broad.mit.edu	37	12	55726304	55726304	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:55726304C>T	ENST00000379667.1	+	1	820	c.820C>T	c.(820-822)Ctc>Ttc	p.L274F		NM_054104.1	NP_473445.1	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C, member 3	274					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						AATAGCTATTCTCAATACATC	0.378000													23	31					0	0	1	0	0
SMC2	10592	broad.mit.edu	37	9	106901465	106901465	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:106901465G>A	ENST00000286398.7	+	25	3751	c.3463G>A	c.(3463-3465)Gtt>Att	p.V1155I	SMC2_ENST00000374787.3_Missense_Mutation_p.V1155I|SMC2_ENST00000374793.3_Missense_Mutation_p.V1155I	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	1155					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						CAATGCAAACGTTCTTTTCAA	0.313000													23	26					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131866933	131866933	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:131866933C>T	ENST00000359827.3	-	17	4137	c.3175G>A	c.(3175-3177)Gcc>Acc	p.A1059T	PLXNA4_ENST00000321063.4_Missense_Mutation_p.A1059T			Q9HCM2	PLXA4_HUMAN	plexin A4	1059	IPT/TIG 3.					integral to membrane|intracellular|plasma membrane		p.A1059T(4)		NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CCCCATACGGCGATGGGTGTG	0.507000													12	26					0	0	1	0	0
SRMS	6725	broad.mit.edu	37	20	62172602	62172602	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:62172602G>T	ENST00000217188.1	-	7	1267	c.1227C>A	c.(1225-1227)gtC>gtA	p.V409V		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	409	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			CGAAGGACCAGACGTCTGACT	0.607000													31	52					3.99451e-17	4.39387e-17	1	1	0
SLC2A10	81031	broad.mit.edu	37	20	45355587	45355587	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:45355587C>A	ENST00000359271.2	+	3	1623	c.1373C>A	c.(1372-1374)gCc>gAc	p.A458D		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	458						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				AACTGGGCGGCCAACCTCTTC	0.542000													44	53					2.59497e-14	2.8301e-14	1	1	0
MRPL45	84311	broad.mit.edu	37	17	36455359	36455359	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36455359G>A	ENST00000312513.5	+	3	448	c.287G>A	c.(286-288)cGc>cAc	p.R96H		NM_032351.4	NP_115727.4	Q9BRJ2	RM45_HUMAN	mitochondrial ribosomal protein L45	96					intracellular protein transport|translation	mitochondrial inner membrane presequence translocase complex|ribosome	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|structural constituent of ribosome			breast(3)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	13	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GGTGATGCACGCATATCATCT	0.383000													43	49					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54969333	54969333	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54969333G>A	ENST00000326764.5	+	14	2433	c.1954G>A	c.(1954-1956)Gcc>Acc	p.A652T	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	615							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GTCGCTGTACGCCGAGAACTT	0.577000													11	50					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67263726	67263726	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67263726G>A	ENST00000258201.4	-	21	3629	c.3382C>T	c.(3382-3384)Cgc>Tgc	p.R1128C	FHOD1_ENST00000567687.1_Missense_Mutation_p.R707C	NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1128					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GAACGCTTGCGTTCCCTAGCA	0.572000													33	50					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157504575	157504575	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:157504575G>T	ENST00000361835.3	-	8	1667	c.1510C>A	c.(1510-1512)Cta>Ata	p.L504I	FCRL5_ENST00000368189.3_Missense_Mutation_p.L504I|FCRL5_ENST00000368191.3_Missense_Mutation_p.L419I|FCRL5_ENST00000356953.4_Missense_Mutation_p.L504I|FCRL5_ENST00000368190.3_Missense_Mutation_p.L504I	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	504	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AACTGGTATAGGATTTGTGGG	0.522000													14	16					0.00244969	0.00248438	1	1	0
MED23	9439	broad.mit.edu	37	6	131921245	131921245	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:131921245G>A	ENST00000403834.3	-	18	2344	c.2171C>T	c.(2170-2172)aCc>aTc	p.T724I	MED23_ENST00000368060.3_Missense_Mutation_p.T718I|MED23_ENST00000368068.3_Missense_Mutation_p.T718I|MED23_ENST00000368053.4_Missense_Mutation_p.T724I|MED23_ENST00000354577.4_Missense_Mutation_p.T724I|MED23_ENST00000545957.1_Missense_Mutation_p.T359I|MED23_ENST00000540546.1_Missense_Mutation_p.T724I|MED23_ENST00000368058.1_Missense_Mutation_p.T724I			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	718					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		ACTCATGATGGTCTGAAGTAT	0.363000													15	19					0	0	1	0	0
NAIF1	203245	broad.mit.edu	37	9	130829094	130829094	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130829094G>A	ENST00000373078.4	-	1	506	c.287C>T	c.(286-288)cCg>cTg	p.P96L		NM_197956.3	NP_931045.1	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	96	Gly-rich.				apoptosis|induction of apoptosis	nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						AGTGGGCCCCGGCGCCTCACC	0.687000													5	43					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47583668	47583668	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:47583668G>A	ENST00000172229.3	+	3	341	c.216G>A	c.(214-216)acG>acA	p.T72T	RP5-1029K10.2_ENST00000514506.1_RNA|NGFR_ENST00000504201.1_5'UTR	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	72					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					CAGGCGTGACGTTCTCCGACG	0.677000													13	19					0	0	1	0	0
RBPMS2	348093	broad.mit.edu	37	15	65041343	65041343	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:65041343G>A	ENST00000300069.4	-	5	541	c.274C>T	c.(274-276)Cgc>Tgc	p.R92C	RBPMS2_ENST00000560606.1_5'UTR	NM_194272.1	NP_919248.1	Q6ZRY4	RBPS2_HUMAN	RNA binding protein with multiple splicing 2	92	RRM.						nucleic acid binding|nucleotide binding			breast(1)|large_intestine(3)|lung(3)|prostate(1)	8						GGATCAAAGCGAATACCCTAC	0.498000													12	62					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151874059	151874059	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:151874059G>A	ENST00000355193.2	-	38	8697	c.8479C>T	c.(8479-8481)Ctg>Ttg	p.L2827L	KMT2C_ENST00000262189.6_Silent_p.L2827L					lysine (K)-specific methyltransferase 2C																		TTTGGAGACAGTACTTCCGTT	0.363000													32	66					0	0	1	0	0
TARS2	80222	broad.mit.edu	37	1	150464910	150464910	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:150464910G>A	ENST00000369064.3	+	7	753	c.719G>A	c.(718-720)tGc>tAc	p.C240Y	TARS2_ENST00000606933.1_Missense_Mutation_p.C240Y|TARS2_ENST00000438568.2_3'UTR|TARS2_ENST00000369054.2_Intron|TARS2_ENST00000463555.1_3'UTR	NM_025150.3	NP_079426.2	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	240					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	GTTGACCTTTGCCAGGGCCCC	0.488000													29	48					0	0	1	0	0
FPGS	2356	broad.mit.edu	37	9	130570836	130570836	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130570836G>A	ENST00000373225.3	+	10	881		c.e10-1		FPGS_ENST00000373247.2_Splice_Site|FPGS_ENST00000393706.2_Splice_Site|FPGS_ENST00000373245.1_Intron|FPGS_ENST00000460181.1_Splice_Site	NM_001018078.1	NP_001018088.1	Q05932	FOLC_HUMAN	folylpolyglutamate synthase						folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7					L-Glutamic Acid(DB00142)	GTCTCCCCTAGTGTCCTCTAT	0.687000													4	12					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16461587	16461587	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16461587G>A	ENST00000358432.5	-	7	1680	c.1526C>T	c.(1525-1527)gCa>gTa	p.A509V		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	509	Fibronectin type-III 2.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CTGCGTCAGTGCCTGCACCTG	0.657000													51	67					0	0	1	0	0
VASH1	22846	broad.mit.edu	37	14	77242591	77242591	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:77242591G>A	ENST00000167106.4	+	5	1520	c.887G>A	c.(886-888)cGc>cAc	p.R296H	VASH1_ENST00000556038.1_3'UTR|RP11-488C13.6_ENST00000556368.1_RNA	NM_014909.4	NP_055724.1	Q7L8A9	VASH1_HUMAN	vasohibin 1	296					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space				breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)|urinary_tract(3)	10			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		GAGCTGGAGCGCCACGCCCGC	0.697000													4	5					0	0	1	0	0
CDC34	997	broad.mit.edu	37	19	537014	537014	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:537014A>G	ENST00000215574.4	+	4	582	c.362_splice	c.e4-1	p.T122_splice		NM_004359.1	NP_004350.1	P49427	UB2R1_HUMAN	cell division cycle 34	122					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(1)	2		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCCACAGGACCATTCTCCT	0.647000													6	51					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	662809	662809	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:662809C>T	ENST00000266383.5	+	14	1733	c.1720C>T	c.(1720-1722)Cgg>Tgg	p.R574W		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	574						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			AGAGCAGAGACGGGGTGACAG	0.672000													18	34					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79581713	79581713	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:79581713C>A	ENST00000372391.2	-	15	2534	c.2529G>T	c.(2527-2529)caG>caT	p.Q843H	DLG5_ENST00000372388.2_Intron	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	843					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			AGATGTCTGTCTGCGTGGAGT	0.537000													16	40					1.33834e-09	1.42249e-09	1	1	0
PPP1R9A	55607	broad.mit.edu	37	7	94750100	94750100	+	Silent	SNP	C	C	T	rs12216695		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:94750100C>T	ENST00000289495.5	+	3	1821	c.1605C>T	c.(1603-1605)ttC>ttT	p.F535F	PPP1R9A_ENST00000340694.4_Silent_p.F535F|PPP1R9A_ENST00000456331.2_Silent_p.F535F|PPP1R9A_ENST00000424654.1_Silent_p.F535F|PPP1R9A_ENST00000433881.1_Silent_p.F535F|PPP1R9A_ENST00000433360.1_Silent_p.F535F	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	535	PDZ.					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TGGGAATATTCGTCAAGACAG	0.398000										HNSCC(28;0.073)			42	66					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107402841	107402841	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:107402841C>T	ENST00000334504.7	-	44	4896	c.4663G>A	c.(4663-4665)Gtc>Atc	p.V1555I	COL4A6_ENST00000545689.1_Missense_Mutation_p.V1531I|COL4A6_ENST00000418180.1_Missense_Mutation_p.V90I|COL4A6_ENST00000538570.1_Missense_Mutation_p.V1498I|COL4A6_ENST00000372216.4_Missense_Mutation_p.V1556I|COL4A6_ENST00000394872.2_Missense_Mutation_p.V1556I	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	1556	Collagen IV NC1.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						GTCTGGCTGACGGGCATCATG	0.572000									Alport syndrome with Diffuse Leiomyomatosis				29	14					0	0	1	0	0
ESYT3	83850	broad.mit.edu	37	3	138189867	138189867	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:138189867G>A	ENST00000389567.4	+	17	1925	c.1740_splice	c.e17+1	p.R580_splice		NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	580						integral to membrane|plasma membrane				breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						CTGGTGCTTCGGGTAAATCTC	0.592000													22	31					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587828	55587828	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:55587828C>A	ENST00000333976.4	+	1	743	c.723C>A	c.(721-723)acC>acA	p.T241T		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				CCTTCTCCACCTGTGCCTCCC	0.507000													17	57					1.45105e-14	1.58388e-14	1	1	0
TTN	7273	broad.mit.edu	37	2	179591839	179591839	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179591839G>A	ENST00000589042.1	-	69	20477	c.20253C>T	c.(20251-20253)tgC>tgT	p.C6751C	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.C6434C|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Silent_p.C5507C|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6434	Ig-like 49.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTGGTACTGCAGCTTGTGC	0.418000													36	57					0	0	1	0	0
PTDSS1	9791	broad.mit.edu	37	8	97312002	97312002	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:97312002C>T	ENST00000517309.1	+	6	1007	c.681C>T	c.(679-681)ggC>ggT	p.G227G	PTDSS1_ENST00000455950.2_Silent_p.G81G|PTDSS1_ENST00000518776.1_3'UTR|PTDSS1_ENST00000522072.1_Silent_p.G24G	NM_014754.1	NP_055569.1	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	227					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|stomach(1)	29	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TGTGCAATGGCGGTGGCATTT	0.493000													12	97					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106827517	106827517	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:106827517C>T	ENST00000228347.4	+	16	1870	c.1648C>T	c.(1648-1650)Cga>Tga	p.R550*	POLR3B_ENST00000539066.1_Nonsense_Mutation_p.R492*	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	550					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						AGGTGTCATTCGAGACCACAA	0.323000													15	61					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733610	50733610	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:50733610G>T	ENST00000300589.2	+	2	390	c.285G>T	c.(283-285)aaG>aaT	p.K95N	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	95	CARD 1.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				TCTGGAATAAGGGTACTTGGG	0.657000													12	26					2.68362e-12	2.90084e-12	1	1	0
GSN	2934	broad.mit.edu	37	9	124094780	124094780	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:124094780G>T	ENST00000373823.3	+	25	3000	c.2095G>T	c.(2095-2097)Ggc>Tgc	p.G699C	GSN_ENST00000373818.4_Missense_Mutation_p.G750C|GSN_ENST00000545652.1_Missense_Mutation_p.G707C|GSN_ENST00000373808.2_Missense_Mutation_p.G699C|GSN_ENST00000412819.1_Missense_Mutation_p.G699C|GSN_ENST00000449733.1_Missense_Mutation_p.G699C|GSN_ENST00000373806.1_Missense_Mutation_p.G175C|GSN_ENST00000341272.2_Missense_Mutation_p.G699C|GSN_ENST00000436847.1_Missense_Mutation_p.G710C|GSN_ENST00000394353.2_Missense_Mutation_p.G710C			P06396	GELS_HUMAN	gelsolin	750	Actin-binding, Ca-sensitive (Potential).				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						GGTGAAGCAAGGCTTTGAGCC	0.597000											OREG0019445	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	17					0.00010058	0.000103117	1	1	0
MIR200B	0	broad.mit.edu	37	1	1102578	1102578	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:1102578G>A	ENST00000384997.1	+	0	95					NR_029639.1																						AGCCCTGCACGCAGCGACCGG	0.711000													4	3					0	0	1	0	0
RNF216	54476	broad.mit.edu	37	7	5800647	5800647	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:5800647G>A	ENST00000425013.2	-	2	278	c.54C>T	c.(52-54)tgC>tgT	p.C18C	RNF216_ENST00000389902.3_Silent_p.C18C	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	18					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		GTCCCCGATGGCAGTGAAAGT	0.378000													25	45					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41801448	41801448	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:41801448C>T	ENST00000396930.3	-	14	2589	c.2046G>A	c.(2044-2046)ccG>ccA	p.P682P	KAT6A_ENST00000265713.2_Silent_p.P682P|KAT6A_ENST00000406337.1_Silent_p.P682P|KAT6A_ENST00000485568.1_Silent_p.P682P	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	682	Catalytic.|Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										GATCAGATAACGGTTTCTCTG	0.393000													35	71					0	0	1	0	0
TJAP1	93643	broad.mit.edu	37	6	43469376	43469376	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:43469376C>T	ENST00000372444.2	+	7	674	c.241C>T	c.(241-243)Ctg>Ttg	p.L81L	TJAP1_ENST00000438588.2_Silent_p.L81L|TJAP1_ENST00000372445.5_Silent_p.L81L|TJAP1_ENST00000372449.1_Silent_p.L81L|TJAP1_ENST00000372452.1_Silent_p.L81L|TJAP1_ENST00000259751.1_Silent_p.L81L|TJAP1_ENST00000436109.2_Silent_p.L81L|TJAP1_ENST00000483640.1_3'UTR	NM_001146018.1	NP_001139490.1	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 (peripheral)	81						Golgi apparatus|tight junction	protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|urinary_tract(2)	21	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGAGCTGGAGCTGGGCCAGAG	0.602000													9	18					0	0	1	0	0
MCM3	4172	broad.mit.edu	37	6	52148119	52148119	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:52148119C>T	ENST00000596288.1	-	2	326	c.299G>A	c.(298-300)cGc>cAc	p.R100H	MCM3_ENST00000229854.7_Missense_Mutation_p.R55H|MCM3_ENST00000419835.2_Intron	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	55					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					GTTTTTCCTGCGCAGGTCATT	0.512000													23	30					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579442	7579442	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7579442G>A	ENST00000420246.2	-	4	377	c.245C>T	c.(244-246)cCg>cTg	p.P82L	TP53_ENST00000359597.4_Missense_Mutation_p.P82L|TP53_ENST00000455263.2_Missense_Mutation_p.P82L|TP53_ENST00000445888.2_Missense_Mutation_p.P82L|TP53_ENST00000413465.2_Missense_Mutation_p.P82L|TP53_ENST00000269305.4_Missense_Mutation_p.P82L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	82	Interaction with HRMT1L2.|Interaction with WWOX.		P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.P82L(8)|p.A76_S90del15(3)|p.G59fs*23(3)|p.V73fs*9(1)|p.R65fs*38(1)|p.D48fs*55(1)|p.A79_A88del10(1)|p.P13fs*18(1)|p.S33fs*23(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGGGCCGCCGGTGTAGGAGC	0.607000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			42	63					0	0	1	0	0
TRAF6	7189	broad.mit.edu	37	11	36511471	36511471	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:36511471G>A	ENST00000526995.1	-	7	1732	c.1486C>T	c.(1486-1488)Cgc>Tgc	p.R496C	TRAF6_ENST00000348124.5_Missense_Mutation_p.R496C	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	496	MATH.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				ACCTCACAGCGCACTAATAAT	0.483000													35	48					0	0	1	0	0
TBCC	6903	broad.mit.edu	37	6	42713704	42713704	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:42713704C>T	ENST00000244625.2	-	2	671	c.108G>A	c.(106-108)cgG>cgA	p.R36R	TBCC_ENST00000372876.1_Silent_p.R36R			Q15814	TBCC_HUMAN	tubulin folding cofactor C	36					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(3)	14	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			CTTCCAGCTGCCGTTCTTGTT	0.597000													27	35					0	0	1	0	0
NEK9	91754	broad.mit.edu	37	14	75563873	75563873	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:75563873C>T	ENST00000238616.5	-	17	2261	c.2103G>A	c.(2101-2103)cgG>cgA	p.R701R		NM_033116.4	NP_149107.4	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	701					cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00718)		CAAAAATAGGCCGAGGCCATG	0.507000													7	18					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57539195	57539195	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57539195C>T	ENST00000243077.3	+	6	1229	c.763C>T	c.(763-765)Cag>Tag	p.Q255*	LRP1_ENST00000338962.4_Nonsense_Mutation_p.Q255*|LRP1_ENST00000554174.1_Nonsense_Mutation_p.Q255*|LRP1_ENST00000553277.1_Nonsense_Mutation_p.Q255*|RP11-545N8.3_ENST00000555461.1_RNA	NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	255					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGCTCAGACGCAGCTCAAGTG	0.582000													15	20					0	0	1	0	0
IGHV1-18	0	broad.mit.edu	37	14	106641879	106641879	+	RNA	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:106641879A>G	ENST00000390605.2	-	0	105																											TGTGGAGAGGACACAGGAGTG	0.582000													24	39					0	0	1	0	0
STXBP4	252983	broad.mit.edu	37	17	53155477	53155477	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:53155477C>T	ENST00000376352.2	+	14	1434	c.1227C>T	c.(1225-1227)ctC>ctT	p.L409L	STXBP4_ENST00000434978.2_Silent_p.L387L	NM_178509.5	NP_848604.3	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	409						cytoplasm	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19						TCATGGTACTCGACTGCCAAT	0.358000													34	42					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146755582	146755582	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:146755582C>T	ENST00000361719.2	+	9	3705	c.3235C>T	c.(3235-3237)Ccg>Tcg	p.P1079S	GRM1_ENST00000355289.4_3'UTR|GRM1_ENST00000282753.1_Missense_Mutation_p.P1079S|GRM1_ENST00000507907.1_3'UTR|GRM1_ENST00000392299.2_3'UTR|GRM1_ENST00000492807.2_3'UTR	NM_001278064.1	NP_001264993.1	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	1079	Gln/Pro-rich.				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GCAGATGCTGCCGCTGCAGCT	0.682000													17	55					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160134088	160134088	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160134088C>T	ENST00000368081.4	+	7	1392	c.921C>T	c.(919-921)gcC>gcT	p.A307A		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	307					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTGTGGTGGCCGTCTTCCTTG	0.522000													60	67					0	0	1	0	0
ITK	3702	broad.mit.edu	37	5	156649954	156649954	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:156649954C>T	ENST00000422843.3	+	6	729	c.577C>T	c.(577-579)Cgg>Tgg	p.R193W	CTB-4E7.1_ENST00000519375.1_RNA	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	193	SH3.		R -> Q (in dbSNP:rs17054374).		cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACTCGCACTGCGGCGCAACGA	0.517000			T	SYK	peripheral T-cell lymphoma								28	54					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33359690	33359690	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:33359690G>A	ENST00000334528.9	-	1	395	c.396C>T	c.(394-396)gaC>gaT	p.D132D	FMN1_ENST00000561249.1_Intron|FMN1_ENST00000558197.1_Silent_p.D132D|FMN1_ENST00000559047.1_Intron|FMN1_ENST00000559150.1_Intron	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	0	Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		AAATGACATCGTCTTTTGTCC	0.527000													19	23					0	0	1	0	0
PLAGL2	5326	broad.mit.edu	37	20	30784255	30784255	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:30784255C>T	ENST00000246229.4	-	3	1755	c.1491G>A	c.(1489-1491)taG>taA	p.*497*		NM_002657.3	NP_002648.1	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	0						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|liver(1)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCTGTGGGGGCTACTGGAATG	0.577000													12	17					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354310	57354310	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:57354310C>A	ENST00000314922.3	-	2	401	c.325G>T	c.(325-327)Ggc>Tgc	p.G109C	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Missense_Mutation_p.G109C	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	109					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TTCATGAAGCCTCCATACCTT	0.488000													34	71					6.50621e-10	6.9326e-10	1	1	0
DROSHA	29102	broad.mit.edu	37	5	31464381	31464381	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:31464381C>T	ENST00000511367.2	-	19	2780	c.2536G>A	c.(2536-2538)Gga>Aga	p.G846R	DROSHA_ENST00000344624.3_Missense_Mutation_p.G846R|DROSHA_ENST00000513349.1_Missense_Mutation_p.G809R|DROSHA_ENST00000442743.1_Missense_Mutation_p.G809R	NM_013235.4	NP_037367.3	Q9NRR4	RNC_HUMAN	drosha, ribonuclease type III	846	Necessary for interaction with DGCR8 and pri-miRNA processing activity.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(19)|lung(33)|ovary(2)|skin(1)	66						TTCCAGAATCCTTGGCTACTT	0.423000													16	23					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74692156	74692156	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:74692156C>T	ENST00000334011.5	+	9	1730	c.1512C>T	c.(1510-1512)gaC>gaT	p.D504D		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	504	ZP.					nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					GAGTGTTGGACGAGCGTTCCC	0.582000													36	72					0	0	1	0	0
LYSMD3	116068	broad.mit.edu	37	5	89814725	89814725	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:89814725G>A	ENST00000315948.6	-	3	976	c.832C>T	c.(832-834)Cca>Tca	p.P278S	LYSMD3_ENST00000509384.1_3'UTR|LYSMD3_ENST00000500869.2_Silent_p.C119C	NM_198273.1	NP_938014.1	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain containing 3	278					cell wall macromolecule catabolic process	integral to membrane				breast(2)|large_intestine(1)|lung(2)|prostate(1)|urinary_tract(1)	7		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		CCTTTAGTTGGCACAATTCCA	0.388000													40	48					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53620387	53620387	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:53620387C>T	ENST00000342160.3	-	31	4135	c.3678G>A	c.(3676-3678)ttG>ttA	p.L1226L	HUWE1_ENST00000218328.8_Silent_p.L1226L|HUWE1_ENST00000262854.6_Silent_p.L1226L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1226					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CACCTCCAGGCAATTTGGCAG	0.473000													25	2					0	0	1	0	0
RAC3	5881	broad.mit.edu	37	17	79991650	79991650	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79991650C>T	ENST00000306897.4	+	6	662	c.524C>T	c.(523-525)gCg>gTg	p.A175V		NM_005052.2	NP_005043.1	P60763	RAC3_HUMAN	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	175					actin cytoskeleton organization|cell projection assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endomembrane system|filamentous actin|growth cone|lamellipodium|neuronal cell body|plasma membrane	GTP binding|GTPase activity|protein binding			NS(1)|kidney(1)|skin(1)	3	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GCGATCCGCGCGGTGCTCTGC	0.662000													10	8					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687898	68687898	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:68687898C>T	ENST00000361320.4	+	2	1802	c.1224C>T	c.(1222-1224)acC>acT	p.T408T	CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000494580.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	408						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						GCCCAGAGACCGATGCTGACG	0.597000													8	18					0	0	1	0	0
GABRG3	2567	broad.mit.edu	37	15	27725917	27725917	+	Silent	SNP	C	C	T	rs77771286	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:27725917C>T	ENST00000333743.6	+	6	950	c.696C>T	c.(694-696)atC>atT	p.I232I	GABRG3_ENST00000555083.1_Silent_p.I232I	NM_033223.4	NP_150092.2	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 3	232					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(23)|skin(1)|upper_aerodigestive_tract(4)	42		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		CCACAGAAATCGTGACAACGT	0.443000													7	8					0	0	1	0	0
PAPD7	11044	broad.mit.edu	37	5	6754936	6754936	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:6754936G>A	ENST00000230859.6	+	13	1636	c.1507G>A	c.(1507-1509)Ggt>Agt	p.G503S		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	503					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CAGCTCTGTGGGTAGCGGAGG	0.597000													9	12					0	0	1	0	0
ZNF672	79894	broad.mit.edu	37	1	249142234	249142234	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:249142234C>T	ENST00000306562.3	+	4	1507	c.761C>T	c.(760-762)cCg>cTg	p.P254L		NM_024836.1	NP_079112.1	Q499Z4	ZN672_HUMAN	zinc finger protein 672	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)	5	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGCGAGAAGCCGTACGCATGT	0.677000													4	3					0	0	1	0	0
TRIM10	10107	broad.mit.edu	37	6	30128254	30128254	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30128254C>T	ENST00000449742.2	-	1	457	c.382G>A	c.(382-384)Gct>Act	p.A128T	TRIM10_ENST00000376704.3_Missense_Mutation_p.A128T	NM_006778.3	NP_006769.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	128						cytoplasm	zinc ion binding			ovary(1)	1						GTGTGGGTAGCGTGCTCCCCA	0.577000													17	17					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5042866	5042866	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:5042866C>T	ENST00000574788.1	+	22	3625	c.1395C>T	c.(1393-1395)ggC>ggT	p.G465G	USP6_ENST00000304328.5_Silent_p.G148G|USP6_ENST00000332776.4_Silent_p.G465G|USP6_ENST00000250066.6_Silent_p.G465G			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	465					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						ATATAGGGGGCCCTTGGTTCC	0.617000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								9	26					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31600654	31600654	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:31600654C>T	ENST00000389082.5	-	6	1943	c.1679G>A	c.(1678-1680)cGc>cAc	p.R560H	DENND5B_ENST00000354285.4_Missense_Mutation_p.R582H|DENND5B_ENST00000536562.1_Missense_Mutation_p.R595H|DENND5B_ENST00000306833.6_Missense_Mutation_p.R595H	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	560	dDENN.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						TTCAATGAAGCGTGAAAGAAA	0.403000													5	9					0	0	1	0	0
EDEM3	80267	broad.mit.edu	37	1	184692925	184692925	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:184692925G>A	ENST00000318130.8	-	8	1079	c.813C>T	c.(811-813)ggC>ggT	p.G271G	EDEM3_ENST00000367512.3_Silent_p.G228G	NM_025191.3	NP_079467.3	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like 3	271					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TTATAGTCACGCCCACTAAAT	0.323000													36	48					0	0	1	0	0
OSBPL6	114880	broad.mit.edu	37	2	179251853	179251853	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179251853G>A	ENST00000190611.4	+	20	2519	c.2143G>A	c.(2143-2145)Gtc>Atc	p.V715I	OSBPL6_ENST00000315022.2_Missense_Mutation_p.V719I|OSBPL6_ENST00000409045.3_Missense_Mutation_p.V684I|OSBPL6_ENST00000359685.3_Missense_Mutation_p.V679I|OSBPL6_ENST00000392505.2_Missense_Mutation_p.V740I|OSBPL6_ENST00000409631.1_Missense_Mutation_p.V679I	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	715					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			AACACTGAATGTCATGCTTCC	0.408000													13	23					0	0	1	0	0
HSPA4L	22824	broad.mit.edu	37	4	128732695	128732695	+	Silent	SNP	C	C	T	rs143377960	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:128732695C>T	ENST00000296464.3	+	12	1893	c.1482C>T	c.(1480-1482)agC>agT	p.S494S	HSPA4L_ENST00000505726.1_Silent_p.S468S|HSPA4L_ENST00000439123.2_Silent_p.S525S|HSPA4L_ENST00000508776.1_Silent_p.S494S	NM_014278.2	NP_055093.2	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	494					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding	p.S494S(1)		central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						GTGTGGCTAGCGCATCAGTAA	0.373000													16	33					0	0	1	0	0
FAM129A	116496	broad.mit.edu	37	1	184772813	184772813	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:184772813T>C	ENST00000367511.3	-	12	1653	c.1460A>G	c.(1459-1461)gAc>gGc	p.D487G	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	487					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						GGTGCTGCTGTCATAATCATA	0.398000													27	45					0	0	1	0	0
GOLGA5	9950	broad.mit.edu	37	14	93303736	93303736	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:93303736G>A	ENST00000163416.2	+	12	2313	c.2057G>A	c.(2056-2058)cGc>cAc	p.R686H	GOLGA5_ENST00000355976.2_Intron	NM_005113.2	NP_005104.2	Q8TBA6	GOGA5_HUMAN	golgin A5	686					Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			large_intestine(6)|lung(1)|ovary(2)	9		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		CACAGTATTCGCCTGGGAATT	0.363000			T	RET	papillary thyroid								90	144					0	0	1	0	0
AP5Z1	9907	broad.mit.edu	37	7	4825975	4825975	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:4825975A>T	ENST00000348624.4	+	10	1321	c.1227A>T	c.(1225-1227)gaA>gaT	p.E409D	AP5Z1_ENST00000401897.1_Missense_Mutation_p.E409D	NM_014855.2	NP_055670.1	O43299	K0415_HUMAN	adaptor-related protein complex 5, zeta 1 subunit	409					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										TGGCCTTTGAATTCATCCAGT	0.572000													40	61					0	0	1	0	0
FBXL13	222235	broad.mit.edu	37	7	102453883	102453883	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:102453883G>T	ENST00000393772.2	-	19	2456	c.2030C>A	c.(2029-2031)cCt>cAt	p.P677H	FBXL13_ENST00000456695.1_Missense_Mutation_p.P423H|FBXL13_ENST00000455112.2_Missense_Mutation_p.P660H|FBXL13_ENST00000436908.1_Missense_Mutation_p.P705H|FBXL13_ENST00000379305.3_Missense_Mutation_p.P677H|FBXL13_ENST00000379306.3_Missense_Mutation_p.P423H|FBXL13_ENST00000379308.3_Missense_Mutation_p.P660H|FBXL13_ENST00000313221.4_Missense_Mutation_p.P705H			Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13	705										NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|skin(3)|stomach(1)	27						CTCTGTAACAGGGTTTCCTTC	0.428000													43	65					2.40228e-13	2.60856e-13	1	1	0
SEZ6	124925	broad.mit.edu	37	17	27287826	27287826	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:27287826T>C	ENST00000317338.12	-	6	1834	c.1406A>G	c.(1405-1407)gAc>gGc	p.D469G	SEZ6_ENST00000442608.3_Missense_Mutation_p.D469G|SEZ6_ENST00000360295.9_Missense_Mutation_p.D469G|SEZ6_ENST00000335960.6_Missense_Mutation_p.D469G|PIPOX_ENST00000583215.1_Intron			Q53EL9	SEZ6_HUMAN	seizure related 6 homolog (mouse)	469	CUB 1.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	29	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			CCCTCACCTGTCATCATCCTC	0.597000													33	37					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44559587	44559587	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:44559587G>A	ENST00000332567.4	-	1	2401	c.2049C>T	c.(2047-2049)caC>caT	p.H683H	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	683					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TGGAGGGAGTGTGGCTGCTTC	0.627000													33	33					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79929492	79929492	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:79929492T>C	ENST00000360280.3	+	37	4584	c.4324T>C	c.(4324-4326)Tat>Cat	p.Y1442H	VPS13A_ENST00000357409.5_Missense_Mutation_p.Y1442H|VPS13A_ENST00000376634.4_Missense_Mutation_p.Y1442H|VPS13A_ENST00000423463.2_3'UTR|VPS13A_ENST00000376636.3_Missense_Mutation_p.Y1403H	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	1442					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TTTAAAAATGTATACAGATGG	0.323000													21	24					0	0	1	0	0
GPR161	23432	broad.mit.edu	37	1	168074014	168074014	+	Silent	SNP	G	G	A	rs115455892	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:168074014G>A	ENST00000367838.1	-	4	388	c.75C>T	c.(73-75)ggC>ggT	p.G25G	GPR161_ENST00000367835.1_Silent_p.G25G|GPR161_ENST00000271357.5_Silent_p.G25G|GPR161_ENST00000539777.1_Intron|GPR161_ENST00000546300.1_Intron|GPR161_ENST00000361697.2_Silent_p.G25G|GPR161_ENST00000367836.1_Intron|GPR161_ENST00000537209.1_Silent_p.G45G	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	25					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					TGATGATGACGCCCCCTTCGC	0.562000													18	30					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17877525	17877525	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:17877525T>C	ENST00000594202.1	+	7	521	c.242T>C	c.(241-243)cTg>cCg	p.L81P	FCHO1_ENST00000596536.1_Missense_Mutation_p.L81P|FCHO1_ENST00000539407.1_Missense_Mutation_p.L81P|FCHO1_ENST00000252771.7_Missense_Mutation_p.L81P|FCHO1_ENST00000597512.1_Missense_Mutation_p.L88P|FCHO1_ENST00000389133.4_Missense_Mutation_p.L81P|FCHO1_ENST00000600676.1_Missense_Mutation_p.L81P|FCHO1_ENST00000596951.1_Missense_Mutation_p.L81P|FCHO1_ENST00000595033.1_Missense_Mutation_p.L31P	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	81	FCH.									NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						TCGGACAAGCTGGCGCTGTGC	0.627000													8	10					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277565	114277565	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:114277565G>A	ENST00000357077.4	+	38	7844	c.7791G>A	c.(7789-7791)atG>atA	p.M2597I	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.M2564I|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2564					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAATCAAAATGTTTGATGAAC	0.383000													30	30					0	0	1	0	0
CHST2	9435	broad.mit.edu	37	3	142841089	142841089	+	Silent	SNP	G	G	A	rs147682013	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:142841089G>A	ENST00000309575.3	+	2	2815	c.1431G>A	c.(1429-1431)acG>acA	p.T477T		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	477					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity	p.T477T(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						GCAATGCCACGCAGGCCGCCA	0.612000													4	29					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28259961	28259961	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28259961C>T	ENST00000354638.3	-	9	1160	c.1005G>A	c.(1003-1005)acG>acA	p.T335T	OCA2_ENST00000353809.5_Silent_p.T335T|OCA2_ENST00000382996.2_Silent_p.T335T	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	335					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CGAGGATGGCCGTCGCGATGG	0.597000									Oculocutaneous Albinism				8	7					0	0	1	0	0
NXPE4	54827	broad.mit.edu	37	11	114452476	114452476	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:114452476A>G	ENST00000375478.3	-	4	1043	c.863T>C	c.(862-864)tTc>tCc	p.F288S	NXPE4_ENST00000424261.2_Missense_Mutation_p.F4S	NM_001077639.1	NP_001071107.1			neurexophilin and PC-esterase domain family, member 4									p.F288C(1)									AATTGTATTGAATTTTTCCAT	0.378000													15	25					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7229303	7229303	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:7229303C>T	ENST00000379938.2	+	10	1508	c.971C>T	c.(970-972)gCg>gTg	p.A324V	RREB1_ENST00000379933.3_Missense_Mutation_p.A324V|RREB1_ENST00000349384.6_Missense_Mutation_p.A324V|RREB1_ENST00000334984.6_Missense_Mutation_p.A324V	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	324					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TGTGACAAGGCGTTCCCCATG	0.592000													14	17					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34072456	34072456	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:34072456C>T	ENST00000389232.4	+	65	9252	c.9182C>T	c.(9181-9183)gCc>gTc	p.A3061V	RYR3_ENST00000415757.3_Missense_Mutation_p.A3061V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3061					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGGCAGCTGCCATACCAGTG	0.567000													9	19					0	0	1	0	0
ABCB10	23456	broad.mit.edu	37	1	229667480	229667480	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:229667480T>C	ENST00000344517.4	-	7	1382		c.e7-2			NM_012089.2	NP_036221.2	Q9NRK6	ABCBA_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 10							integral to mitochondrial membrane|mitochondrial inner membrane	ATP binding|oligopeptide-transporting ATPase activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)	31	Breast(184;0.143)|Ovarian(103;0.249)	Prostate(94;0.167)				AGCTCAGACCTGAGGATGAGA	0.527000													18	19					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31611156	31611156	+	Silent	SNP	A	A	G	rs45462996	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:31611156A>G	ENST00000379416.3	-	7	549	c.501T>C	c.(499-501)ggT>ggC	p.G167G	XDH_ENST00000491727.1_5'UTR	NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	167					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CACAGCATCCACCATCCTAGA	0.443000													13	44					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9013508	9013508	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:9013508C>T	ENST00000299698.7	+	27	3476	c.3296C>T	c.(3295-3297)gCg>gTg	p.A1099V	A2ML1_ENST00000539547.1_Missense_Mutation_p.A608V	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	943						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						TCCTTGACTGCGTATGTCACA	0.512000											OREG0021663	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	110					0	0	1	0	0
HMOX1	3162	broad.mit.edu	37	22	35782786	35782786	+	Missense_Mutation	SNP	C	C	T	rs141730669	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:35782786C>T	ENST00000216117.8	+	3	592	c.253C>T	c.(253-255)Cgc>Tgc	p.R85C		NM_002133.2	NP_002124.1	P09601	HMOX1_HUMAN	heme oxygenase (decycling) 1	85					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	16					NADH(DB00157)	AGAGCTGCACCGCAAGGCTGC	0.627000													20	23					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36595998	36595998	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:36595998T>C	ENST00000299440.5	+	2	1256	c.1144T>C	c.(1144-1146)Tca>Cca	p.S382P		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	382					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				TCACAAGGAATCAAAAGAGAT	0.478000									Familial Hemophagocytic Lymphohistiocytosis				8	34					0	0	1	0	0
CHRM4	1132	broad.mit.edu	37	11	46407071	46407071	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46407071G>A	ENST00000433765.2	-	1	1036	c.1037C>T	c.(1036-1038)aCg>aTg	p.T346M		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	346					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	TGTCTGCTTCGTCACAATCTG	0.662000													14	208					0	0	1	0	0
ZNF319	0	broad.mit.edu	37	16	58032066	58032066	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:58032066G>A	ENST00000299237.2	-	2	726	c.104C>T	c.(103-105)aCg>aTg	p.T35M		NM_020807.1	NP_065858.1	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	35	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8						CGGAGGCAGCGTGTGCTCTGC	0.701000													21	21					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168819908	168819908	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:168819908G>A	ENST00000464456.1	-	9	3320	c.2120C>T	c.(2119-2121)gCg>gTg	p.A707V	MECOM_ENST00000433243.2_Missense_Mutation_p.A717V|MECOM_ENST00000472280.1_Missense_Mutation_p.A717V|MECOM_ENST00000392736.3_Missense_Mutation_p.A716V|MECOM_ENST00000468789.1_Missense_Mutation_p.A716V|MECOM_ENST00000264674.3_Missense_Mutation_p.A781V|MECOM_ENST00000460814.1_Missense_Mutation_p.A707V|MECOM_ENST00000494292.1_Missense_Mutation_p.A895V	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						ATTGGGAGGCGCCCTGAAGTT	0.502000													17	24					0	0	1	0	0
NKAIN3	286183	broad.mit.edu	37	8	63492147	63492147	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:63492147C>T	ENST00000523211.1	+	2	236	c.104C>T	c.(103-105)gCg>gTg	p.A35V	NKAIN3_ENST00000328472.5_Missense_Mutation_p.A35V|NKAIN3_ENST00000519049.1_3'UTR	NM_173688.2	NP_775959.1	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	35						integral to membrane|plasma membrane		p.A35G(1)		kidney(3)|large_intestine(2)|lung(8)	13	Breast(64;0.127)	Lung NSC(129;0.187)				TTCCAGTGGGCGCCTATTCTT	0.383000													6	64					0	0	1	0	0
UFD1L	7353	broad.mit.edu	37	22	19455394	19455394	+	Splice_Site	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:19455394A>G	ENST00000263202.9	-	5	552		c.e5+1		UFD1L_ENST00000484101.1_Splice_Site|UFD1L_ENST00000360834.4_Splice_Site|UFD1L_ENST00000399523.1_Splice_Site	NM_001035247.2|NM_005659.6	NP_001030324.2|NP_005650.2	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1 like (yeast)						skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity			large_intestine(3)|upper_aerodigestive_tract(1)	4	Colorectal(54;0.0993)					TGAAAAAGATACACGGCTTTG	0.493000													17	81					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139904444	139904444	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139904444G>A	ENST00000265662.5	-	42	6633	c.6486C>T	c.(6484-6486)gaC>gaT	p.D2162D	ABCA2_ENST00000371605.3_Silent_p.D2161D|ABCA2_ENST00000341511.6_Silent_p.D2162D			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	2161	ABC transporter 2.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCCGGGCCTCGTCCTTCCAGG	0.692000													3	5					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142459692	142459692	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142459692G>A	ENST00000486171.1	+	4	327	c.310G>A	c.(310-312)Gca>Aca	p.A104T	PRSS1_ENST00000311737.7_Missense_Mutation_p.A90T			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	90	Peptidase S1.		L -> P (in PCTT).		digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GTTCATCAATGCAGCCAAGAT	0.537000													56	63					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1614036	1614036	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:1614036C>T	ENST00000426508.2	-	17	2392	c.2029G>A	c.(2029-2031)Gca>Aca	p.A677T	IFT140_ENST00000439987.2_5'UTR	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	677										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				TGCCCGTTTGCAGACTGAGGC	0.567000													23	26					0	0	1	0	0
VAC14	55697	broad.mit.edu	37	16	70796857	70796857	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:70796857G>A	ENST00000261776.5	-	11	1492	c.1232C>T	c.(1231-1233)aCg>aTg	p.T411M	VAC14-AS1_ENST00000562507.1_RNA|VAC14-AS1_ENST00000398177.1_RNA	NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	411					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				CCCAATGGCCGTGTCACTGAG	0.577000													11	15					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31815671	31815671	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:31815671C>T	ENST00000446923.2	+	9	3197	c.2806C>T	c.(2806-2808)Cga>Tga	p.R936*	ZEB1_ENST00000560721.2_Nonsense_Mutation_p.R932*|ZEB1_ENST00000320985.10_Nonsense_Mutation_p.R952*|ZEB1_ENST00000361642.5_Nonsense_Mutation_p.R953*|ZEB1_ENST00000542815.3_Nonsense_Mutation_p.R885*	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	952					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.R952*(1)		NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TGAACACATGCGATTACATTC	0.363000													20	17					0	0	1	0	0
DLX3	1747	broad.mit.edu	37	17	48069204	48069204	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48069204G>T	ENST00000434704.2	-	3	766	c.541C>A	c.(541-543)Cgt>Agt	p.R181S	DLX3_ENST00000512495.2_Missense_Mutation_p.R61S	NM_005220.2	NP_005211.1	O60479	DLX3_HUMAN	distal-less homeobox 3	181						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	12						AACTTGGAACGGCGGTTCTGG	0.522000													23	36					2.98393e-07	3.1252e-07	1	1	0
AGMO	392636	broad.mit.edu	37	7	15405839	15405839	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:15405839C>T	ENST00000342526.3	-	11	1252	c.1083G>A	c.(1081-1083)tcG>tcA	p.S361S		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	361					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						GAGTAACTTGCGACAGTGCCT	0.403000													6	8					0	0	1	0	0
PLK2	10769	broad.mit.edu	37	5	57751419	57751419	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:57751419G>A	ENST00000274289.3	-	11	1872	c.1572C>T	c.(1570-1572)acC>acT	p.T524T	PLK2_ENST00000502671.1_Intron	NM_001252226.1|NM_006622.3	NP_001239155.1|NP_006613.2	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	524	POLO box 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(7)|large_intestine(7)|lung(5)|ovary(3)|prostate(2)|skin(2)	26		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		GGACACCGACGGTGTGGTCTG	0.448000													7	30					0	0	1	0	0
TRIM8	81603	broad.mit.edu	37	10	104416970	104416970	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:104416970G>A	ENST00000302424.6	+	6	1637	c.1515G>A	c.(1513-1515)ccG>ccA	p.P505P		NM_030912.2	NP_112174.2	Q9BZR9	TRIM8_HUMAN	tripartite motif containing 8	505						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ACTCACACCCGCTCCCGCCCA	0.667000													7	12					0	0	1	0	0
CRYGB	1419	broad.mit.edu	37	2	209010717	209010717	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:209010717G>T	ENST00000260988.4	-	2	80	c.33C>A	c.(31-33)gcC>gcA	p.A11A		NM_005210.3	NP_005201.2	P07316	CRGB_HUMAN	crystallin, gamma B	11	Beta/gamma crystallin 'Greek key' 1.				visual perception		structural constituent of eye lens			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)	14				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		GGCCCTGGAAGGCCCTGTCCT	0.572000													24	26					5.61819e-17	6.17723e-17	1	1	0
CDH26	60437	broad.mit.edu	37	20	58564159	58564159	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:58564159C>T	ENST00000348616.4	+	9	1524	c.1224C>T	c.(1222-1224)ggC>ggT	p.G408G	CDH26_ENST00000244047.5_Silent_p.G408G	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	408	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			AAGAGGAGGGCGCCAGGCCTG	0.562000													53	109					0	0	1	0	0
RP11-535M15.2	0	broad.mit.edu	37	9	99489025	99489025	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:99489025G>A	ENST00000602289.1	+	0	14																											AAGTGCATTCGCAAGTGGAGC	0.483000													6	17					0	0	1	0	0
YAE1D1	57002	broad.mit.edu	37	7	39612284	39612284	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:39612284A>G	ENST00000223273.2	+	3	703	c.660A>G	c.(658-660)ttA>ttG	p.L220L	YAE1D1_ENST00000432096.2_Intron	NM_020192.3	NP_064577.1	Q9NRH1	CG036_HUMAN	Yae1 domain containing 1	220																	TAGATGTATTACAACACCTCA	0.383000													27	31					0	0	1	0	0
RP3-412A9.11	0	broad.mit.edu	37	22	31501210	31501210	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31501210C>T	ENST00000402395.1	-	6	680	c.263G>A	c.(262-264)cGc>cAc	p.R88H	RP3-412A9.11_ENST00000400299.2_Missense_Mutation_p.R88H|RP3-412A9.11_ENST00000465536.1_5'UTR																							TTCCTCGTAGCGGCGGCCCAG	0.692000													7	16					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144838070	144838070	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:144838070T>C	ENST00000367545.3	+	38	5527	c.5527T>C	c.(5527-5529)Tac>Cac	p.Y1843H		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1843					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GCATACTAGATACAACAAAAT	0.333000													27	25					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109182308	109182308	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:109182308C>T	ENST00000326495.5	-	15	2699	c.2606G>A	c.(2605-2607)gGc>gAc	p.G869D	SSH1_ENST00000360239.3_Missense_Mutation_p.G557D	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	869					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AACCAGGGGGCCCAGCTCGTG	0.672000													6	8					0	0	1	0	0
CROCCP3	0	broad.mit.edu	37	1	16803488	16803488	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16803488G>A	ENST00000263511.4	-	0	2268					NR_023386.1																						GCAGTGTGGCGCGGCTCAGCG	0.642000													4	4					0	0	1	0	0
DYNC1LI2	1783	broad.mit.edu	37	16	66770078	66770078	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:66770078G>T	ENST00000258198.2	-	5	805	c.599C>A	c.(598-600)cCt>cAt	p.P200H	DYNC1LI2_ENST00000379482.2_Intron|DYNC1LI2_ENST00000440564.2_Missense_Mutation_p.P161H|DYNC1LI2_ENST00000443351.2_Missense_Mutation_p.P123H	NM_006141.2	NP_006132.1	O43237	DC1L2_HUMAN	dynein, cytoplasmic 1, light intermediate chain 2	200					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(4)|stomach(1)	15		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		TGAGGTCAGAGGGCCTCTTCT	0.483000													16	20					2.32078e-09	2.46314e-09	1	1	0
ZNF781	163115	broad.mit.edu	37	19	38160644	38160644	+	Missense_Mutation	SNP	C	C	T	rs149425681	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38160644C>T	ENST00000358582.4	-	4	1154	c.406G>A	c.(406-408)Gga>Aga	p.G136R	ZFP30_ENST00000586732.1_Intron|ZNF781_ENST00000590008.1_Missense_Mutation_p.G136R	NM_152605.3	NP_689818.2	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24						GTGAATTTTCCGATGTCTATT	0.368000													36	48					0	0	1	0	0
DHCR24	1718	broad.mit.edu	37	1	55340837	55340837	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55340837C>T	ENST00000371269.3	-	4	639	c.541G>A	c.(541-543)Ggc>Agc	p.G181S	DHCR24_ENST00000537443.1_Missense_Mutation_p.G13S|DHCR24_ENST00000535035.1_Missense_Mutation_p.G140S	NM_014762.3	NP_055577.1	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase	181	FAD-binding PCMH-type.				anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			large_intestine(2)|liver(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7						TGGAACAGGCCGTACTTGTGG	0.562000													17	41					0	0	1	0	0
SEC63	11231	broad.mit.edu	37	6	108214837	108214837	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:108214837C>A	ENST00000369002.4	-	16	1702	c.1523G>T	c.(1522-1524)aGg>aTg	p.R508M		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	508	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TCCTTTTGTCCTGTTCTTGTT	0.348000													6	115					1.12685e-05	1.16601e-05	1	1	0
PTPRCAP	5790	broad.mit.edu	37	11	67203470	67203470	+	Missense_Mutation	SNP	C	C	T	rs138577657	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67203470C>T	ENST00000326294.3	-	2	802	c.355G>A	c.(355-357)Gcg>Acg	p.A119T		NM_005608.2	NP_005599.1	Q14761	PTCA_HUMAN	protein tyrosine phosphatase, receptor type, C-associated protein	119					defense response	integral to membrane|plasma membrane		p.A119T(1)		skin(1)|upper_aerodigestive_tract(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CCACCATCCGCGACGTGGTCA	0.657000													9	17					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154317603	154317603	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:154317603G>A	ENST00000368489.3	+	22	2542	c.2542G>A	c.(2542-2544)Gga>Aga	p.G848R		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	834					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CATTGGAGACGGAGCCAATGA	0.572000											OREG0013835	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	55					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121345607	121345607	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:121345607G>A	ENST00000338040.4	+	4	2394	c.1980G>A	c.(1978-1980)atG>atA	p.M660I		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	660					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		TCACCTCCATGTCTGAGCACC	0.463000													51	76					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47308006	47308006	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:47308006T>C	ENST00000342922.4	+	15	2931	c.2574T>C	c.(2572-2574)agT>agC	p.S858S	MADD_ENST00000402192.2_Silent_p.S858S|MADD_ENST00000395336.3_Silent_p.S858S|MADD_ENST00000402799.1_Silent_p.S815S|MADD_ENST00000406482.1_Silent_p.S815S|MADD_ENST00000311027.5_Silent_p.S858S|MADD_ENST00000349238.3_Silent_p.S858S|MADD_ENST00000407859.3_Silent_p.S815S|MADD_ENST00000395344.3_Silent_p.S815S	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	858					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		GGAACCACAGTACCAGCTTCA	0.507000													40	52					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118366536	118366536	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118366536G>T	ENST00000534358.1	+	19	5508	c.5485G>T	c.(5485-5487)Gct>Tct	p.A1829S	KMT2A_ENST00000389506.5_Missense_Mutation_p.A1826S|KMT2A_ENST00000354520.4_Missense_Mutation_p.A1788S	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AATCATTCCAGCTCCCAAACC	0.493000													55	67					7.05995e-25	7.87918e-25	1	1	0
HEPACAM2	253012	broad.mit.edu	37	7	92848481	92848481	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:92848481G>A	ENST00000394468.2	-	2	440	c.363C>T	c.(361-363)atC>atT	p.I121I	HEPACAM2_ENST00000453812.2_Silent_p.I144I|HEPACAM2_ENST00000440868.1_Silent_p.I109I|HEPACAM2_ENST00000341723.4_Silent_p.I109I	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	121						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						TGACCTTCACGATGTAATTGC	0.483000													19	46					0	0	1	0	0
GALNT15	117248	broad.mit.edu	37	3	16268936	16268936	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:16268936C>A	ENST00000339732.5	+	10	2352	c.1849C>A	c.(1849-1851)Ctg>Atg	p.L617M	GALNT15_ENST00000437509.1_Intron	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		AGATTTGTACCTGCGTCCGTG	0.413000													4	66					0.000602214	0.000612743	1	1	0
BRD1	23774	broad.mit.edu	37	22	50187716	50187716	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50187716G>A	ENST00000216267.8	-	6	2811	c.2325C>T	c.(2323-2325)gaC>gaT	p.D775D	BRD1_ENST00000342989.5_Silent_p.D370D|BRD1_ENST00000404034.1_Silent_p.D775D|BRD1_ENST00000542442.1_Silent_p.D463D|BRD1_ENST00000404760.1_Silent_p.D775D|BRD1_ENST00000457780.2_Silent_p.D775D	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	775					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCGCAGCTCCGTCCTCTTCGA	0.652000													15	17					0	0	1	0	0
ESCO1	114799	broad.mit.edu	37	18	19110307	19110307	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:19110307C>T	ENST00000269214.5	-	12	3457	c.2520G>A	c.(2518-2520)acG>acA	p.T840T		NM_052911.2	NP_443143.2	Q5FWF5	ESCO1_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 1	840					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			breast(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(10)|prostate(3)|upper_aerodigestive_tract(1)	35						ATTTGTTTTACGTGCTATTCT	0.383000													19	32					0	0	1	0	0
TRDMT1	1787	broad.mit.edu	37	10	17210864	17210864	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:17210864C>T	ENST00000377799.3	-	3	274	c.227G>A	c.(226-228)aGc>aAc	p.S76N	TRDMT1_ENST00000358282.7_Intron|TRDMT1_ENST00000377766.5_Intron|TRDMT1_ENST00000457442.2_Intron|TRDMT1_ENST00000412821.3_Missense_Mutation_p.S76N|TRDMT1_ENST00000452380.2_5'UTR|TRDMT1_ENST00000488990.1_Intron|TRDMT1_ENST00000351358.4_Missense_Mutation_p.S76N	NM_004412.5	NP_004403.1	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1	76					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	18						GCAGGGAGGGCTCATTAAAAT	0.383000													10	16					0	0	1	0	0
FZD7	8324	broad.mit.edu	37	2	202900778	202900778	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:202900778C>T	ENST00000286201.1	+	1	1469	c.1408C>T	c.(1408-1410)Cgc>Tgc	p.R470C		NM_003507.1	NP_003498.1	O75084	FZD7_HUMAN	frizzled family receptor 7	470					axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|endometrium(6)|large_intestine(6)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	31						GCTCATGGTGCGCATCGGCGT	0.617000											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	37					0	0	1	0	0
MTMR9	66036	broad.mit.edu	37	8	11163708	11163708	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:11163708C>T	ENST00000221086.3	+	5	1074	c.601C>T	c.(601-603)Cga>Tga	p.R201*	MTMR9_ENST00000526292.1_Nonsense_Mutation_p.R116*	NM_015458.3	NP_056273.2	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	201	Myotubularin phosphatase.					cytoplasm	phosphatase activity|protein binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(2)	16			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		GGTAATTATGCGAAGTGGTCA	0.418000													5	18					0	0	1	0	0
ATG9A	79065	broad.mit.edu	37	2	220089410	220089410	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:220089410A>G	ENST00000409618.1	-	8	1122	c.683T>C	c.(682-684)cTg>cCg	p.L228P	ATG9A_ENST00000361242.4_Missense_Mutation_p.L228P|ATG9A_ENST00000409422.1_Missense_Mutation_p.L167P|ATG9A_ENST00000396761.2_Missense_Mutation_p.L228P			Q7Z3C6	ATG9A_HUMAN	autophagy related 9A	228					autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				endometrium(2)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(1)	13		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGCAGAGGCAGGAGGGATTT	0.552000													23	31					0	0	1	0	0
ACN9	57001	broad.mit.edu	37	7	96747188	96747188	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:96747188G>T	ENST00000432641.2	+	1	1287	c.153G>T	c.(151-153)caG>caT	p.Q51H	ACN9_ENST00000360382.4_Missense_Mutation_p.Q51H	NM_020186.2	NP_064571.1	Q9NRP4	ACN9_HUMAN	ACN9 homolog (S. cerevisiae)	51					regulation of gluconeogenesis	mitochondrial intermembrane space				large_intestine(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(3)	10	all_cancers(62;2.54e-08)|all_epithelial(64;2.24e-08)|Esophageal squamous(72;0.00507)|all_lung(186;0.154)|Lung NSC(181;0.159)					ACGAGGCACAGCGTTTCTTGC	0.552000													33	31					1.02151e-06	1.06508e-06	1	1	0
MLLT6	4302	broad.mit.edu	37	17	36879020	36879020	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:36879020C>T	ENST00000325718.7	+	18	2973	c.2883_splice	c.e18+1	p.P961_splice		NM_005937.3	NP_005928.2	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	961	Gln-rich.				regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(7;4.43e-21)					CAGCTGACCCCGGTAATGCCC	0.642000			T	MLL	AL								4	11					0	0	1	0	0
GAL	51083	broad.mit.edu	37	11	68456356	68456356	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:68456356G>A	ENST00000265643.3	+	5	521	c.263G>A	c.(262-264)cGc>cAc	p.R88H		NM_015973.3	NP_057057.2	P22466	GALA_HUMAN	galanin/GMAP prepropeptide	88					growth hormone secretion|insulin secretion|neuropeptide signaling pathway|smooth muscle contraction	extracellular region	neuropeptide hormone activity			lung(4)	4	Esophageal squamous(3;7.33e-10)	Melanoma(852;0.0749)	LUAD - Lung adenocarcinoma(13;0.0514)	Kidney(183;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.000152)|LUSC - Lung squamous cell carcinoma(976;0.00154)		AATATCATGCGCACAATCATT	0.403000													37	46					0	0	1	0	0
HAUS6	54801	broad.mit.edu	37	9	19058263	19058263	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:19058263G>A	ENST00000380502.3	-	16	2969	c.2502C>T	c.(2500-2502)cgC>cgT	p.R834R	HAUS6_ENST00000380496.1_Silent_p.R698R	NM_017645.3	NP_060115.3	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	834					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CGTATCTACTGCGAAGAGCCT	0.448000													43	91					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3682283	3682283	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:3682283G>A	ENST00000344754.4	-	6	1233	c.1234C>T	c.(1234-1236)Cct>Tct	p.P412S	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.P412S	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	412	Ig-like C2-type 4.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GGAGTGAGAGGCGGGTCTGTG	0.612000													6	10					0	0	1	0	0
ASB1	51665	broad.mit.edu	37	2	239344584	239344584	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:239344584C>T	ENST00000264607.4	+	3	671	c.424C>T	c.(424-426)Cac>Tac	p.H142Y	ASB1_ENST00000409297.1_Intron	NM_001040445.1	NP_001035535.1	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box containing 1	142					intracellular signal transduction|negative regulation of cytokine biosynthetic process					breast(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		CGGAAGCCGGCACCATCGCAG	0.637000													5	8					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220161053	220161053	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:220161053G>A	ENST00000295718.2	-	18	2643	c.2403C>T	c.(2401-2403)agC>agT	p.S801S	PTPRN_ENST00000423636.2_Silent_p.S711S|PTPRN_ENST00000409251.3_Silent_p.S772S|PTPRN_ENST00000497977.1_5'UTR	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	801	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CGGTGCAGCCGCTCTCCCACA	0.607000													27	33					0	0	1	0	0
HHLA2	11148	broad.mit.edu	37	3	108072521	108072521	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:108072521G>A	ENST00000357759.5	+	4	726	c.312G>A	c.(310-312)gcG>gcA	p.A104A	HHLA2_ENST00000467562.1_Intron|HHLA2_ENST00000489514.2_Silent_p.A104A|HHLA2_ENST00000467761.1_Silent_p.A104A|HHLA2_ENST00000491820.1_Silent_p.A104A	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	104	Ig-like V-type 1.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						ATGGGAATGCGTCGCTATTTT	0.403000													12	24					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117788703	117788703	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:117788703G>A	ENST00000276204.6	+	43	4908	c.4834G>A	c.(4834-4836)Gca>Aca	p.A1612T	DOCK11_ENST00000276202.7_Missense_Mutation_p.A1612T			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1612	DHR-2.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CAAGTCCTATGCAAGCACCCC	0.433000													41	5					0	0	1	0	0
TMEM168	64418	broad.mit.edu	37	7	112423833	112423833	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:112423833G>A	ENST00000312814.5	-	2	1608	c.1048C>T	c.(1048-1050)Cgc>Tgc	p.R350C	TMEM168_ENST00000454074.1_Missense_Mutation_p.R350C	NM_022484.4	NP_071929.3	Q9H0V1	TM168_HUMAN	transmembrane protein 168	350						integral to membrane|transport vesicle				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|stomach(1)	32						CAAAAATGGCGCATCCCTTTG	0.403000													51	75					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108389096	108389096	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:108389096C>T	ENST00000263054.6	-	19	2533	c.2526G>A	c.(2524-2526)gcG>gcA	p.A842A	SORCS1_ENST00000344440.6_Silent_p.A842A|SORCS1_ENST00000369698.1_Silent_p.A377A	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	842	PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CGTAAGACACCGCGATACCAT	0.502000													4	33					0	0	1	0	0
ZNF611	81856	broad.mit.edu	37	19	53208330	53208330	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53208330C>T	ENST00000543227.1	-	6	2252	c.1978G>A	c.(1978-1980)Gtg>Atg	p.V660M	ZNF611_ENST00000319783.1_Missense_Mutation_p.V660M|ZNF611_ENST00000602162.1_Missense_Mutation_p.V591M|ZNF611_ENST00000540744.1_Missense_Mutation_p.V660M|ZNF611_ENST00000595798.1_Missense_Mutation_p.V591M|ZNF611_ENST00000453741.2_Missense_Mutation_p.V591M	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	660					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		GAATTACGCACGAAAGCCTTG	0.408000													54	86					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167643796	167643796	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:167643796C>T	ENST00000519204.1	+	21	3857	c.3739C>T	c.(3739-3741)Ctc>Ttc	p.L1247F	TENM2_ENST00000403607.2_Missense_Mutation_p.L1192F|TENM2_ENST00000545108.1_Missense_Mutation_p.L1367F|TENM2_ENST00000520394.1_Missense_Mutation_p.L1129F|TENM2_ENST00000518659.1_Missense_Mutation_p.L1368F					teneurin transmembrane protein 2																		CAAGAATGGGCTCATGTACTT	0.537000													13	34					0	0	1	0	0
GABBR1	0	broad.mit.edu	37	6	29599357	29599357	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:29599357C>T	ENST00000377034.4	-	3	440	c.105G>A	c.(103-105)ccG>ccA	p.P35P	GABBR1_ENST00000377016.4_Silent_p.P35P|GABBR1_ENST00000376977.3_Silent_p.P35P	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	35	Sushi 1.				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	CTTCCCAGGGCGGGTGTATGA	0.592000													18	39					0	0	1	0	0
FERMT3	83706	broad.mit.edu	37	11	63990633	63990633	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:63990633A>G	ENST00000279227.5	+	14	1891	c.1796A>G	c.(1795-1797)cAg>cGg	p.Q599R	FERMT3_ENST00000345728.5_Missense_Mutation_p.Q595R	NM_178443.2	NP_848537.1	Q86UX7	URP2_HUMAN	fermitin family member 3	599					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						AACATGCGCCAGTGGAATGTC	0.622000													19	23					0	0	1	0	0
TRABD	80305	broad.mit.edu	37	22	50636868	50636868	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50636868C>A	ENST00000303434.4	+	10	1170	c.1051C>A	c.(1051-1053)Cgc>Agc	p.R351S	TRABD_ENST00000395829.1_Missense_Mutation_p.R351S|TRABD_ENST00000380909.4_Missense_Mutation_p.R351S|TRABD_ENST00000395827.1_Missense_Mutation_p.R351S	NM_025204.2	NP_079480.2	Q9H4I3	TRABD_HUMAN	TraB domain containing	351										breast(1)|central_nervous_system(1)|large_intestine(1)|liver(2)|lung(1)|upper_aerodigestive_tract(1)	7		all_cancers(38;1.07e-07)|all_epithelial(38;9.6e-07)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		LUAD - Lung adenocarcinoma(64;0.105)		CTGGATGGGCCGCCGCACCGC	0.711000													3	4					0.115264	0.115739	1	1	0
TRIM7	81786	broad.mit.edu	37	5	180622224	180622224	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:180622224C>T	ENST00000393315.1	-	7	1551	c.854G>A	c.(853-855)cGc>cAc	p.R285H	TRIM7_ENST00000361809.3_Missense_Mutation_p.R285H|TRIM7_ENST00000274773.7_Missense_Mutation_p.R493H|TRIM7_ENST00000393319.3_Missense_Mutation_p.R311H|TRIM7_ENST00000422067.2_Missense_Mutation_p.R285H|TRIM7_ENST00000504241.1_5'UTR	NM_203296.1	NP_976041.1	Q9C029	TRIM7_HUMAN	tripartite motif containing 7	493						cytoplasm|nucleus	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|stomach(1)	17	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		CGGGAACACGCGCTCCTGGAA	0.647000													3	9					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33015926	33015926	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:33015926G>A	ENST00000280979.4	+	4	2237	c.2067G>A	c.(2065-2067)aaG>aaA	p.K689K	AKAP6_ENST00000557354.1_Silent_p.K689K|AKAP6_ENST00000557272.1_Silent_p.K689K	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	689					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCAAAAAGAAGCATACAAGGC	0.443000													24	56					0	0	1	0	0
MEF2C	4208	broad.mit.edu	37	5	88119602	88119602	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:88119602C>T	ENST00000504921.2	-	2	676	c.4G>A	c.(4-6)Ggg>Agg	p.G2R	MEF2C_ENST00000424173.2_Missense_Mutation_p.G2R|MEF2C_ENST00000510942.1_Missense_Mutation_p.G2R|MEF2C_ENST00000506554.1_Missense_Mutation_p.G2R|MEF2C_ENST00000437473.2_Missense_Mutation_p.G2R|MEF2C_ENST00000539796.1_Missense_Mutation_p.G2R|MEF2C_ENST00000340208.5_Missense_Mutation_p.G2R|MEF2C_ENST00000508569.1_Missense_Mutation_p.G2R|MEF2C_ENST00000514028.1_Missense_Mutation_p.G2R|MEF2C_ENST00000514015.1_Missense_Mutation_p.G2R			Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C	2					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	40		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		TTTTTTCTCCCCATAGTCCCC	0.338000										HNSCC(66;0.2)			42	98					0	0	1	0	0
TREH	11181	broad.mit.edu	37	11	118531315	118531315	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118531315C>T	ENST00000529101.1	-	10	1080	c.1035G>A	c.(1033-1035)gtG>gtA	p.V345V	TREH_ENST00000525958.1_Silent_p.V314V|TREH_ENST00000530256.1_Silent_p.V222V|TREH_ENST00000397925.1_Silent_p.V314V|TREH_ENST00000264029.4_Silent_p.V345V			O43280	TREA_HUMAN	trehalase (brush-border membrane glycoprotein)	345					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			NS(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		GGTCAACAGGCACCAGTTTGC	0.567000													5	9					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159129420	159129420	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:159129420C>T	ENST00000297239.9	+	7	707	c.513C>T	c.(511-513)ggC>ggT	p.G171G	SYTL3_ENST00000360448.3_Silent_p.G171G|SYTL3_ENST00000367081.3_Intron			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	171					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		GCAGTCCTGGCAGGGTAACGT	0.557000													5	24					0	0	1	0	0
ZNF609	23060	broad.mit.edu	37	15	64962553	64962553	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:64962553G>A	ENST00000326648.3	+	3	1110	c.982G>A	c.(982-984)Gtg>Atg	p.V328M	ZNF609_ENST00000559364.1_3'UTR	NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	328						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AGGGATGTTGGTGGTAAATGT	0.423000													29	25					0	0	1	0	0
ANKK1	255239	broad.mit.edu	37	11	113270280	113270280	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:113270280C>A	ENST00000303941.3	+	8	1683	c.1589C>A	c.(1588-1590)cCa>cAa	p.P530Q		NM_178510.1	NP_848605.1	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	530							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|stomach(1)	29		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		CTGAGAACACCACTGCACCTG	0.612000													5	4					0.00116845	0.0011864	1	1	0
ZNF468	90333	broad.mit.edu	37	19	53345180	53345180	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53345180T>C	ENST00000595646.1	-	4	487	c.367A>G	c.(367-369)Aca>Gca	p.T123A	ZNF468_ENST00000390651.4_Missense_Mutation_p.T70A|ZNF468_ENST00000396409.4_Missense_Mutation_p.T70A|ZNF28_ENST00000594602.1_Intron|ZNF468_ENST00000243639.4_3'UTR			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		TGTTGGCCTGTACTACCAGCC	0.428000													5	218					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25365068	25365068	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:25365068C>T	ENST00000330560.3	+	15	3363	c.2886C>T	c.(2884-2886)ggC>ggT	p.G962G	CDCA2_ENST00000521098.2_3'UTR|CDCA2_ENST00000380665.3_Silent_p.G947G	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	962					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		ACAGCCAGGGCCCTGCTGCTG	0.478000													87	136					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72828024	72828024	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:72828024C>T	ENST00000268489.5	-	9	9229	c.8557G>A	c.(8557-8559)Gca>Aca	p.A2853T	ZFHX3_ENST00000397992.5_Missense_Mutation_p.A1939T	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2853					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.A2853T(1)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TCGTTATCTGCGTTGCCCTCG	0.473000													55	66					0	0	1	0	0
NSFL1C	55968	broad.mit.edu	37	20	1426346	1426346	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:1426346G>A	ENST00000216879.4	-	8	1782	c.915C>T	c.(913-915)ggC>ggT	p.G305G	NSFL1C_ENST00000350991.4_Silent_p.G307G|NSFL1C_ENST00000381658.4_Silent_p.G194G|NSFL1C_ENST00000353088.2_Silent_p.G274G|NSFL1C_ENST00000476071.1_Silent_p.G307G|NSFL1C_ENST00000461211.1_5'UTR	NM_016143.4	NP_057227.2	Q9UNZ2	NSF1C_HUMAN	NSFL1 (p97) cofactor (p47)	305	UBX.					chromosome|Golgi stack|nucleus	lipid binding|protein binding			breast(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	16						CCAGCCTCCCGCCGTCTGCAA	0.517000													101	37					0	0	1	0	0
KIAA1967	0	broad.mit.edu	37	8	22465543	22465543	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22465543C>T	ENST00000308511.4	+	7	798	c.549C>T	c.(547-549)gcC>gcT	p.A183A	KIAA1967_ENST00000389279.3_Silent_p.A183A|KIAA1967_ENST00000520861.1_5'UTR			Q8N163	K1967_HUMAN		183					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|skin(5)	25		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		GATTTCCTGCCCGGGGCCCTC	0.463000													73	140					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15826541	15826541	+	Silent	SNP	C	C	T	rs149980738		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:15826541C>T	ENST00000338282.6	-	27	3637	c.3531G>A	c.(3529-3531)acG>acA	p.T1177T	MYH11_ENST00000576790.1_Silent_p.T1177T|AF001548.5_ENST00000574212.1_RNA|MYH11_ENST00000452625.2_Silent_p.T1184T|MYH11_ENST00000396324.3_Silent_p.T1184T|MYH11_ENST00000300036.5_Silent_p.T1177T	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1177					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						TCTTCAGCACCGTCACCTCCT	0.587000			T	CBFB	AML								20	24					0	0	1	0	0
PCDHGC3	0	broad.mit.edu	37	5	140857013	140857013	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140857013C>T	ENST00000308177.3	+	1	1434	c.1330C>T	c.(1330-1332)Cgt>Tgt	p.R444C	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000518882.1_Intron	NM_002588.2|NM_032402.1	NP_002579.2|NP_115778.1												p.R444C(2)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(2)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACAATAGTGCGTGTTCAAGT	0.522000													27	30					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9515129	9515129	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9515129C>A	ENST00000402466.1	+	21	3879	c.3111C>A	c.(3109-3111)tcC>tcA	p.S1037S	SETD5_ENST00000406341.1_Silent_p.S1135S|SETD5_ENST00000302463.6_Silent_p.S1037S|SETD5_ENST00000407969.1_Silent_p.S1154S|SETD5_ENST00000402198.1_Silent_p.S1135S			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1135										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		CATCTCATTCCTCTATGTCCC	0.507000													5	11					0.184627	0.185007	1	1	0
KCNJ5	3762	broad.mit.edu	37	11	128781383	128781383	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:128781383G>A	ENST00000529694.1	+	2	591	c.215G>A	c.(214-216)cGg>cAg	p.R72Q	KCNJ5_ENST00000533599.1_Missense_Mutation_p.R72Q|KCNJ5_ENST00000338350.4_Missense_Mutation_p.R72Q	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	72					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	GAGACCTACCGGTACCTGAGT	0.597000													32	46					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151829826	151829826	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:151829826C>T	ENST00000535741.1	-	10	1818	c.1345G>A	c.(1345-1347)Gca>Aca	p.A449T	LRBA_ENST00000357115.3_Missense_Mutation_p.A449T|LRBA_ENST00000507224.1_Missense_Mutation_p.A449T|LRBA_ENST00000510413.1_Missense_Mutation_p.A449T			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	449						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					AGCATGAGTGCATGTGGTGAA	0.383000													25	36					0	0	1	0	0
ACSM3	6296	broad.mit.edu	37	16	20797543	20797543	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:20797543C>T	ENST00000440284.2	+	9	1424	c.1287C>T	c.(1285-1287)cgC>cgT	p.R429R	ACSM3_ENST00000289416.5_Intron|ACSM3_ENST00000450120.2_Intron|ACSM3_ENST00000567387.1_Intron|ERI2_ENST00000300005.3_Intron	NM_202000.2	NP_973729.1	Q53FZ2	ACSM3_HUMAN	acyl-CoA synthetase medium-chain family member 3	0					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	21						CTACCTACCGCTTACCCCCAT	0.363000													7	9					0	0	1	0	0
TMEM8A	58986	broad.mit.edu	37	16	425225	425225	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:425225G>A	ENST00000431232.2	-	8	1507	c.1347C>T	c.(1345-1347)agC>agT	p.S449S	TMEM8A_ENST00000250930.3_Silent_p.S256S	NM_021259.2	NP_067082.2	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8A	449					cell adhesion	integral to plasma membrane				central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	14						GAGACCAGGCGCTCAGAGACA	0.642000													15	14					0	0	1	0	0
DCP1A	55802	broad.mit.edu	37	3	53338246	53338246	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:53338246G>A	ENST00000607628.1	-	6	694	c.585C>T	c.(583-585)acC>acT	p.T195T	DCP1A_ENST00000606822.1_Intron|DCP1A_ENST00000294241.6_Silent_p.T195T|DCP1A_ENST00000480258.1_5'UTR	NM_018403.5	NP_060873.4	Q9NPI6	DCP1A_HUMAN	decapping mRNA 1A	195					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		CTAGAGTCTCGGTGCTTCCCA	0.418000													18	32					0	0	1	0	0
GPX2	2877	broad.mit.edu	37	14	65406370	65406370	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:65406370G>A	ENST00000389614.5	-	2	495	c.409C>T	c.(409-411)Ccc>Tcc	p.P137S	CHURC1-FNTB_ENST00000542227.1_Intron|CHURC1-FNTB_ENST00000447296.2_Intron	NM_002083.3	NP_002074.2	P18283	GPX2_HUMAN	glutathione peroxidase 2 (gastrointestinal)	137					response to oxidative stress	cytoplasm	electron carrier activity|glutathione peroxidase activity			large_intestine(2)|ovary(1)|skin(1)	4				all cancers(60;0.00117)|OV - Ovarian serous cystadenocarcinoma(108;0.00557)|BRCA - Breast invasive adenocarcinoma(234;0.00971)	Glutathione(DB00143)	ATGAGCTTGGGATCGGTCATG	0.547000													23	32					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31352794	31352794	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:31352794C>T	ENST00000542188.1	-	10	1580	c.1267G>A	c.(1267-1269)Gtg>Atg	p.V423M	TRPM1_ENST00000256552.6_Missense_Mutation_p.V406M|TRPM1_ENST00000397795.2_Missense_Mutation_p.V384M	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	384					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GCTATGTCCACGCGGTTCCAA	0.483000													7	16					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44249479	44249479	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:44249479C>T	ENST00000262419.6	-	2	501	c.31G>A	c.(31-33)Gca>Aca	p.A11T	KANSL1_ENST00000574590.1_Missense_Mutation_p.A11T|KANSL1_ENST00000575318.1_Missense_Mutation_p.A11T|KANSL1_ENST00000393476.3_5'UTR|KANSL1_ENST00000572904.1_Missense_Mutation_p.A11T|KANSL1_ENST00000432791.1_Missense_Mutation_p.A11T	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	11						MLL1 complex	protein binding										TCAGCTGCTGCGTCAGTGAGA	0.602000													21	47					0	0	1	0	0
RHOD	29984	broad.mit.edu	37	11	66834253	66834253	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66834253G>A	ENST00000308831.2	+	3	350	c.265G>A	c.(265-267)Gcc>Acc	p.A89T	RHOD_ENST00000532559.1_Intron|RHOD_ENST00000533360.1_Missense_Mutation_p.A89T	NM_014578.3	NP_055393.1	O00212	RHOD_HUMAN	ras homolog family member D	89					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			lung(3)	3						CTACCCTGACGCCAGCGTCCT	0.612000													38	61					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152637993	152637993	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152637993A>G	ENST00000367255.5	-	87	17302	c.16701T>C	c.(16699-16701)atT>atC	p.I5567I	SYNE1_ENST00000448038.1_Silent_p.I5496I|SYNE1_ENST00000356820.4_Silent_p.I91I|SYNE1_ENST00000341594.5_Silent_p.I5179I|SYNE1_ENST00000423061.1_Silent_p.I5496I|SYNE1_ENST00000265368.4_Silent_p.I5567I	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5567					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTGATGCAAAATATATTGTT	0.363000										HNSCC(10;0.0054)			18	23					0	0	1	0	0
GLIPR2	152007	broad.mit.edu	37	9	36162402	36162402	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:36162402C>T	ENST00000377960.4	+	5	382	c.348C>T	c.(346-348)ggC>ggT	p.G116G	GLIPR2_ENST00000396613.3_3'UTR|GLIPR2_ENST00000474050.1_3'UTR|GLIPR2_ENST00000377959.1_Silent_p.G90G	NM_022343.2	NP_071738.1	Q9H4G4	GAPR1_HUMAN	GLI pathogenesis-related 2	116				TGHFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNVVN EGFFEENVLPPKK -> IRFFFFNFLLFLSKPLLYFSYF (in Ref. 3; BAC11019).		extracellular region|Golgi membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(3)	10						AGAAGATGGGCGTGGGGAAGG	0.562000													14	37					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47585445	47585445	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:47585445C>T	ENST00000253048.5	-	10	1363	c.1326G>A	c.(1324-1326)atG>atA	p.M442I	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	442							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGATATCGTGCATATAAGGGC	0.463000													31	36					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143095461	143095461	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:143095461G>A	ENST00000275815.3	-	7	1503	c.1417C>T	c.(1417-1419)Cga>Tga	p.R473*		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	473	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CCAGGGCTTCGGGGCCGGGAC	0.607000													17	22					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6751119	6751119	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:6751119G>T	ENST00000378827.4	+	2	1565	c.346_splice	c.e2+1	p.E116_splice		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	116					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	CCACCATGAAGGTGAGGCATG	0.687000													11	15					7.03913e-09	7.44699e-09	1	1	0
ZNF497	162968	broad.mit.edu	37	19	58867511	58867511	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:58867511C>T	ENST00000311044.3	-	3	1679	c.1491G>A	c.(1489-1491)gcG>gcA	p.A497A	CTD-2619J13.8_ENST00000599109.1_RNA|ZNF497_ENST00000425453.3_Silent_p.A497A	NM_198458.2	NP_940860.2	Q6ZNH5	ZN497_HUMAN	zinc finger protein 497	497					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|lung(3)|skin(2)	7		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0278)		CGGGTCAGGGCGCAGCGCGGC	0.697000													7	11					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28501363	28501363	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28501363G>A	ENST00000261609.7	-	18	2726	c.2618C>T	c.(2617-2619)gCc>gTc	p.A873V		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	873					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CGCACTGCTGGCCAGGGTCAC	0.662000													6	8					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111617288	111617288	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:111617288G>A	ENST00000428084.1	-	8	872	c.600C>T	c.(598-600)caC>caT	p.H200H	DOCK4_ENST00000476846.1_5'UTR|DOCK4_ENST00000437633.1_Silent_p.H200H			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	200					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				CAAAGAGGTGGTGACTGCTGG	0.502000													7	9					0	0	1	0	0
FPGT	8790	broad.mit.edu	37	1	74670868	74670868	+	Silent	SNP	C	C	T	rs41289176		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:74670868C>T	ENST00000370898.2	+	4	1174	c.1137C>T	c.(1135-1137)ctC>ctT	p.L379L	FPGT_ENST00000524915.1_Intron|TNNI3K_ENST00000370891.2_Intron|FPGT-TNNI3K_ENST00000370895.1_Intron|FPGT_ENST00000370894.4_Intron|TNNI3K_ENST00000370893.1_Intron|FPGT_ENST00000534056.1_Intron|FPGT-TNNI3K_ENST00000370899.3_Intron|FPGT-TNNI3K_ENST00000557284.1_Intron	NM_001199328.1|NM_003838.3	NP_001186257.1|NP_003829.2			fucose-1-phosphate guanylyltransferase											breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	39						AGTCAGAGCTCGGCTTACAGT	0.338000													27	40					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21628905	21628905	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:21628905C>T	ENST00000328843.6	+	12	2084	c.2053C>T	c.(2053-2055)Cgt>Tgt	p.R685C	DNAH11_ENST00000409508.3_Missense_Mutation_p.R685C			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	685	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ATTTGAAAGTCGTATCTATAA	0.333000									Kartagener syndrome				23	25					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152730298	152730298	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:152730298C>T	ENST00000367255.5	-	44	7046	c.6445G>A	c.(6445-6447)Gga>Aga	p.G2149R	SYNE1_ENST00000448038.1_Missense_Mutation_p.G2156R|SYNE1_ENST00000341594.5_Missense_Mutation_p.G2186R|SYNE1_ENST00000423061.1_Missense_Mutation_p.G2156R|SYNE1_ENST00000265368.4_Missense_Mutation_p.G2149R	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2149					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAGTGTTTTCCTTTGCTGGTA	0.358000										HNSCC(10;0.0054)			21	34					0	0	1	0	0
TMEM260	54916	broad.mit.edu	37	14	57103318	57103318	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:57103318T>C	ENST00000261556.6	+	15	1991		c.e15+2		RP11-1085N6.2_ENST00000553800.1_RNA|RP11-1085N6.2_ENST00000555924.1_RNA|TMEM260_ENST00000536419.1_Splice_Site	NM_017799.3	NP_060269.3			transmembrane protein 260																		GCATATGACGTATGTTACACT	0.373000													16	22					0	0	1	0	0
KIF5B	3799	broad.mit.edu	37	10	32329372	32329372	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:32329372T>C	ENST00000302418.4	-	3	685	c.228A>G	c.(226-228)ggA>ggG	p.G76G		NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	76	Kinesin-motor.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				TTCCATTATATCCTTCAAGTA	0.343000			T	"""RET, ALK"""	NSCLC								3	24					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44466582	44466582	+	Missense_Mutation	SNP	C	C	T	rs7528392	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:44466582C>T	ENST00000372306.3	-	11	1620	c.1481G>A	c.(1480-1482)cGc>cAc	p.R494H	SLC6A9_ENST00000357730.2_Intron|SLC6A9_ENST00000475075.2_Intron|SLC6A9_ENST00000360584.2_Intron|SLC6A9_ENST00000372307.3_Intron|SLC6A9_ENST00000372310.3_Intron|SLC6A9_ENST00000537678.1_Intron			P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	652						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	ACAGAGTGGGCGGGCCAAGGG	0.617000													16	14					0	0	1	0	0
C9orf117	286207	broad.mit.edu	37	9	130471805	130471805	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130471805G>A	ENST00000373295.2	+	2	306	c.266G>A	c.(265-267)cGc>cAc	p.R89H		NM_001012502.2	NP_001012520.2	Q5JU67	CI117_HUMAN	chromosome 9 open reading frame 117	89										breast(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	6						TTCCTCAAGCGCACGCTCAAC	0.557000													7	19					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106770185	106770185	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:106770185G>A	ENST00000228347.4	+	7	675	c.453G>A	c.(451-453)acG>acA	p.T151T	POLR3B_ENST00000539066.1_Silent_p.T93T	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	151					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						CAGGAAAAACGCCAGCAGAAT	0.373000													22	36					0	0	1	0	0
HSDL2	84263	broad.mit.edu	37	9	115166427	115166427	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:115166427C>A	ENST00000398805.3	+	2	397	c.170C>A	c.(169-171)gCt>gAt	p.A57D	HSDL2_ENST00000398803.1_Missense_Mutation_p.A57D|HSDL2_ENST00000539114.1_5'UTR|HSDL2_ENST00000262542.7_Intron|HSDL2_ENST00000488101.1_Intron	NM_032303.4	NP_115679.2	Q6YN16	HSDL2_HUMAN	hydroxysteroid dehydrogenase like 2	57						peroxisome	oxidoreductase activity|sterol binding			NS(1)|breast(2)|cervix(2)|endometrium(1)|large_intestine(2)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	13						ATCTATACTGCTGCTGAAGAA	0.388000													20	38					1.56452e-12	1.69366e-12	1	1	0
ASRGL1	80150	broad.mit.edu	37	11	62156674	62156674	+	Silent	SNP	C	C	T	rs150568119		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62156674C>T	ENST00000415229.2	+	5	776	c.561C>T	c.(559-561)ggC>ggT	p.G187G	ASRGL1_ENST00000301776.5_Silent_p.G187G|ASRGL1_ENST00000535727.1_Silent_p.G59G	NM_001083926.1	NP_001077395.1	Q7L266	ASGL1_HUMAN	asparaginase like 1	187					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	7					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	CCTCCACAGGCGGTATCGTTA	0.542000													53	58					0	0	1	0	0
GPR20	2843	broad.mit.edu	37	8	142367678	142367678	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:142367678C>T	ENST00000377741.3	-	2	436	c.346G>A	c.(346-348)Gcc>Acc	p.A116T		NM_005293.2	NP_005284.2	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	116						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(3)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	15	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CAGCCCCTGGCGCCGTAGTAC	0.617000													21	20					0	0	1	0	0
PCDHGC4	0	broad.mit.edu	37	5	140866578	140866578	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140866578C>T	ENST00000306593.1	+	1	1838	c.1838C>T	c.(1837-1839)gCc>gTc	p.A613V	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000518882.1_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCTGGAGGCCCCAGATCCC	0.557000													16	15					0	0	1	0	0
MDH2	4191	broad.mit.edu	37	7	75686750	75686750	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:75686750G>A	ENST00000315758.5	+	3	352	c.258G>A	c.(256-258)ctG>ctA	p.L86L	MDH2_ENST00000432020.2_Silent_p.L86L|MDH2_ENST00000490105.1_3'UTR|MDH2_ENST00000443006.1_5'UTR	NM_005918.2	NP_005909.2	P40926	MDHM_HUMAN	malate dehydrogenase 2, NAD (mitochondrial)	86					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(2)	14					NADH(DB00157)	CTGAACAGCTGCCTGACTGCC	0.522000													18	39					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55930826	55930826	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:55930826G>A	ENST00000389286.4	-	14	2420	c.2373C>T	c.(2371-2373)taC>taT	p.Y791Y		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	791	Fibronectin type-III 4.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		CGGCAAATTCGTATTTGGTGT	0.393000													15	33					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	154002379	154002379	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:154002379G>A	ENST00000496811.1	-	19	2365	c.2285C>T	c.(2284-2286)gCg>gTg	p.A762V	DHX36_ENST00000544526.1_Missense_Mutation_p.A748V|DHX36_ENST00000308361.6_Intron|DHX36_ENST00000329463.5_Missense_Mutation_p.A748V	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	762						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TACCTCAAACGCATTCACAAC	0.299000													12	19					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149216065	149216065	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:149216065C>T	ENST00000309241.5	+	8	2079	c.2047C>T	c.(2047-2049)Cgt>Tgt	p.R683C	PPARGC1B_ENST00000403750.1_Missense_Mutation_p.R619C|PPARGC1B_ENST00000360453.4_Missense_Mutation_p.R644C|PPARGC1B_ENST00000394320.3_Missense_Mutation_p.R683C	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	683					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TGGCCAGAAGCGTCCCTTCTC	0.627000													16	24					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92818563	92818563	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:92818563G>A	ENST00000440868.1	-	8	1395	c.1345C>T	c.(1345-1347)Cag>Tag	p.Q449*	HEPACAM2_ENST00000453812.2_3'UTR|HEPACAM2_ENST00000394468.2_3'UTR|HEPACAM2_ENST00000341723.4_3'UTR|HEPACAM2_ENST00000492616.1_5'UTR			A8MVW5	HECA2_HUMAN	HEPACAM family member 2	0						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						CGAATGTACTGTTTAGCCCAT	0.318000													19	28					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170025112	170025112	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:170025112A>G	ENST00000263816.3	-	61	11857	c.11572T>C	c.(11572-11574)Tat>Cat	p.Y3858H		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3858	LDL-receptor class A 34.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CATTTCCAATATGGCGGGATA	0.473000													25	14					0	0	1	0	0
MKX	283078	broad.mit.edu	37	10	28023550	28023550	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:28023550G>A	ENST00000375790.5	-	5	1105	c.673C>T	c.(673-675)Cgt>Tgt	p.R225C	MKX_ENST00000419761.1_Missense_Mutation_p.R225C			Q8IYA7	MKX_HUMAN	mohawk homeobox	225					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						TTAAGGTAACGGTTCAACAAG	0.483000													26	48					0	0	1	0	0
LIMD1	8994	broad.mit.edu	37	3	45636598	45636598	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:45636598G>A	ENST00000273317.4	+	1	248	c.227G>A	c.(226-228)gGc>gAc	p.G76D	LIMD1_ENST00000465039.1_Intron|LIMD1_ENST00000440097.1_Missense_Mutation_p.G76D	NM_014240.2	NP_055055.1	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	76	Mediates nuclear export.				cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		GGGAGTAGAGGCCCTGTCAAT	0.637000													9	12					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73021272	73021272	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:73021272C>T	ENST00000263674.3	+	1	1939	c.1589C>T	c.(1588-1590)aCg>aTg	p.T530M		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	530					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						TCACCTGGCACGCGCCCCACA	0.632000													6	14					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2214517	2214517	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2214517G>A	ENST00000398665.3	+	19	1881	c.1845G>A	c.(1843-1845)tcG>tcA	p.S615S	DOT1L_ENST00000586024.1_3'UTR|AC004490.1_ENST00000585593.1_RNA	NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	615						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding	p.S615S(2)		NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACGCTGTCGCTGGAGAAGC	0.647000													11	9					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52713679	52713679	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52713679C>T	ENST00000356770.4	-	1	51	c.49G>A	c.(49-51)Ggg>Agg	p.G17R	PBRM1_ENST00000409767.1_Missense_Mutation_p.G17R|PBRM1_ENST00000409057.1_Missense_Mutation_p.G17R|PBRM1_ENST00000394830.3_Missense_Mutation_p.G17R|PBRM1_ENST00000410007.1_Missense_Mutation_p.G17R|PBRM1_ENST00000409114.3_Missense_Mutation_p.G17R|PBRM1_ENST00000337303.4_Missense_Mutation_p.G17R|PBRM1_ENST00000296302.7_Missense_Mutation_p.G17R			Q86U86	PB1_HUMAN	polybromo 1	17					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TCAAAGTCCCCGCTGACACTG	0.448000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								8	35					0	0	1	0	0
IL3RA	3563	broad.mit.edu	37	X	1497614	1497614	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:1497614G>A	ENST00000331035.4	+	10	1286	c.937G>A	c.(937-939)Ggg>Agg	p.G313R	IL3RA_ENST00000381469.2_Missense_Mutation_p.G235R	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	313						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GATCGCGCTGGGGACGCTGCT	0.642000													10	15					0	0	1	0	0
DR1	1810	broad.mit.edu	37	1	93812296	93812296	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:93812296G>A	ENST00000370272.3	+	1	852	c.94G>A	c.(94-96)Gcc>Acc	p.A32T	DR1_ENST00000370267.1_Missense_Mutation_p.A32T	NM_001938.2	NP_001929.1	Q01658	NC2B_HUMAN	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	32					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex	sequence-specific DNA binding|TBP-class protein binding|transcription corepressor activity			endometrium(3)|large_intestine(1)	4		all_lung(203;0.00252)|Lung NSC(277;0.011)|Melanoma(281;0.155)		all cancers(265;0.0032)|GBM - Glioblastoma multiforme(16;0.0165)|Epithelial(280;0.0977)		TGTCCGGGTGGCCAACGATGC	0.448000													43	58					0	0	1	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47115612	47115612	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:47115612G>A	ENST00000290341.3	+	6	818	c.484G>A	c.(484-486)Gga>Aga	p.G162R	IGF2BP1_ENST00000431824.2_Intron	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	162					CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GATAGCACAGGGACCTGAGAA	0.632000													8	50					0	0	1	0	0
CLEC4C	170482	broad.mit.edu	37	12	7894041	7894041	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:7894041C>T	ENST00000542353.1	-	4	701	c.211G>A	c.(211-213)Gtc>Atc	p.V71I	CLEC4C_ENST00000354629.5_Missense_Mutation_p.V40I|CLEC4C_ENST00000360345.3_Missense_Mutation_p.V71I|CLEC4C_ENST00000540085.1_Missense_Mutation_p.V40I	NM_130441.2	NP_569708.1	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C	71					innate immune response	integral to membrane	sugar binding	p.V71I(2)		autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				Kidney(36;0.0915)		CCTTCCATGACGCAGGTCAGG	0.418000													22	48					0	0	1	0	0
C17orf97	400566	broad.mit.edu	37	17	263856	263856	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:263856C>T	ENST00000360127.6	+	2	1238	c.1222C>T	c.(1222-1224)Ctt>Ttt	p.L408F	C17orf97_ENST00000571106.1_Intron	NM_001013672.4	NP_001013694.4	Q6ZQX7	CQ097_HUMAN	chromosome 17 open reading frame 97	438										breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)	14						TGAAGGAAACCTTACCCCAAA	0.507000													25	56					0	0	1	0	0
KIT	3815	broad.mit.edu	37	4	55604673	55604673	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:55604673G>A	ENST00000288135.5	+	21	2978	c.2881G>A	c.(2881-2883)Ggc>Agc	p.G961S		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	961					male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.G961S(1)		NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CAATTCTGTCGGCAGCACCGC	0.527000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				50	71					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16436967	16436967	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:16436967C>T	ENST00000380672.4	-	6	1282	c.1225G>A	c.(1225-1227)Gcc>Acc	p.A409T	BNC2_ENST00000380667.2_Missense_Mutation_p.A342T|BNC2_ENST00000380666.2_Missense_Mutation_p.A409T|BNC2_ENST00000545497.1_Missense_Mutation_p.A314T	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		CTGACTGGGGCAGAATTCTGA	0.463000													15	35					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118772814	118772814	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118772814C>T	ENST00000334801.3	-	6	2602	c.1638G>A	c.(1636-1638)ctG>ctA	p.L546L	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	546					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TCATGTCCTGCAGAGGACGGC	0.632000													10	30					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144809945	144809945	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:144809945C>A	ENST00000367545.3	+	29	4109	c.4109C>A	c.(4108-4110)gCt>gAt	p.A1370D		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1370	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AGGATAGATGCTTTCCAAGTT	0.488000													11	11					1.08611e-07	1.14056e-07	1	1	0
GJB6	0	broad.mit.edu	37	13	20797512	20797512	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:20797512G>A	ENST00000356192.6	-	5	728	c.108C>T	c.(106-108)ctC>ctT	p.L36L	GJB6_ENST00000400066.3_Silent_p.L36L|GJB6_ENST00000400065.3_Silent_p.L36L|GJB6_ENST00000241124.6_Silent_p.L36L	NM_001110219.2	NP_001103689.1	O95452	CXB6_HUMAN	gap junction protein, beta 6, 30kDa	36					cell communication|sensory perception of sound	connexon complex|integral to membrane|intracellular membrane-bounded organelle				biliary_tract(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	9		all_cancers(29;2.04e-22)|all_epithelial(30;1.19e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;2.17e-05)|Epithelial(112;0.00075)|OV - Ovarian serous cystadenocarcinoma(117;0.00978)|Lung(94;0.0238)|GBM - Glioblastoma multiforme(144;0.0323)|LUSC - Lung squamous cell carcinoma(192;0.0744)		CAGCCACCACGAGGATCATGA	0.532000													39	56					0	0	1	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74372693	74372693	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:74372693C>A	ENST00000429810.2	-	0	1503																											CTCCATCCACCTGGCTCCCTG	0.493000													8	18					0.0477658	0.0480142	1	1	0
DCAF15	90379	broad.mit.edu	37	19	14070696	14070696	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:14070696G>A	ENST00000254337.6	+	9	1450	c.1429G>A	c.(1429-1431)Gtc>Atc	p.V477I		NM_138353.2	NP_612362.2	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	477										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)	11						CTATGACATCGTCATTCTGGA	0.597000											OREG0025301	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	25					0	0	1	0	0
CDCA3	83461	broad.mit.edu	37	12	6958585	6958585	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:6958585G>A	ENST00000538862.2	-	5	1454	c.553C>T	c.(553-555)Cgc>Tgc	p.R185C	CDCA3_ENST00000535406.1_Missense_Mutation_p.R185C|CDCA3_ENST00000229265.6_Missense_Mutation_p.R160C|CDCA3_ENST00000540683.1_Intron|CDCA3_ENST00000422785.3_Intron			Q99618	CDCA3_HUMAN	cell division cycle associated 3	185					cell division|mitosis	cytosol				breast(1)|endometrium(1)|large_intestine(4)|lung(1)|stomach(1)	8						CATCTATTGCGCATAGAACCT	0.512000													18	17					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156843599	156843599	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156843599G>A	ENST00000368196.3	+	8	1145	c.1025G>A	c.(1024-1026)cGg>cAg	p.R342Q	NTRK1_ENST00000392302.2_Missense_Mutation_p.R312Q|NTRK1_ENST00000358660.3_Missense_Mutation_p.R342Q|NTRK1_ENST00000524377.1_Missense_Mutation_p.R342Q	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	342	Ig-like C2-type 2.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.R312Q(3)|p.R342Q(3)		breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GAGACCGTGCGGCACGGGTGT	0.632000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			8	19					0	0	1	0	0
HSPA12A	259217	broad.mit.edu	37	10	118466749	118466749	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118466749C>T	ENST00000369209.3	-	2	192	c.88G>A	c.(88-90)Gac>Aac	p.D30N		NM_025015.2	NP_079291.2	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	30							ATP binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32				all cancers(201;0.0158)		ATTCCTGTGTCCCCAAGACTC	0.542000													4	12					0	0	1	0	0
THUMPD2	80745	broad.mit.edu	37	2	39964026	39964026	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:39964026G>A	ENST00000505747.1	-	10	1388	c.1361C>T	c.(1360-1362)gCg>gTg	p.A454V	THUMPD2_ENST00000260619.6_Missense_Mutation_p.A424V	NM_025264.4	NP_079540.2	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	454							methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	17		all_hematologic(82;0.248)				TGAAGTTGACGCTGTCTTGAA	0.423000													16	138					0	0	1	0	0
ZNF326	284695	broad.mit.edu	37	1	90487883	90487883	+	Silent	SNP	G	G	A	rs146247512	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:90487883G>A	ENST00000340281.4	+	11	1523	c.1380G>A	c.(1378-1380)gcG>gcA	p.A460A	ZNF326_ENST00000370447.2_Silent_p.A371A|ZNF326_ENST00000455342.2_Silent_p.A254A	NM_182976.2	NP_892021.1	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(7)|ovary(1)	25		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		TAGTGAAGGCGCGATATGAAC	0.328000													38	154					0	0	1	0	0
ZNF649	65251	broad.mit.edu	37	19	52394712	52394712	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:52394712C>A	ENST00000354957.3	-	5	961	c.677G>T	c.(676-678)aGa>aTa	p.R226I	ZNF649_ENST00000600738.1_Intron|CTC-429C10.2_ENST00000600329.1_RNA	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TCTGTGAGCTCTCTCGTGTTC	0.498000													11	80					4.68919e-08	4.93693e-08	1	1	0
VAMP5	10791	broad.mit.edu	37	2	85818895	85818895	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:85818895G>A	ENST00000306384.4	+	2	134	c.51G>A	c.(49-51)acG>acA	p.T17T		NM_006634.2	NP_006625.1	O95183	VAMP5_HUMAN	vesicle-associated membrane protein 5	17	v-SNARE coiled-coil homology.			T -> M (in Ref. 2; AAF36111).	cell differentiation|vesicle-mediated transport	endomembrane system				NS(1)|large_intestine(3)|lung(1)	5						ACGAGGTGACGGAAATTATGC	0.602000													20	43					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097501	167097501	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:167097501A>G	ENST00000361200.2	+	6	3299	c.3133A>G	c.(3133-3135)Acc>Gcc	p.T1045A	DUSP27_ENST00000271385.5_Missense_Mutation_p.T1045A|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Missense_Mutation_p.T1045A			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1045					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CTTCCGCCGGACCCCAGAGTC	0.582000													5	9					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139724618	139724618	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:139724618C>T	ENST00000263549.3	-	12	2721	c.1848G>A	c.(1846-1848)acG>acA	p.T616T		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	616	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding	p.T616T(1)		endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					CCAGGAACATCGTGTGGGTCT	0.597000													13	18					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8499806	8499806	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:8499806C>A	ENST00000381196.4	-	22	2706	c.2163G>T	c.(2161-2163)gaG>gaT	p.E721D	PTPRD_ENST00000356435.5_Missense_Mutation_p.E721D|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.E721D|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000360074.4_Missense_Mutation_p.E708D|PTPRD_ENST00000358503.5_Missense_Mutation_p.E708D|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	721	Fibronectin type-III 5.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AGTTGACAGCCTCTACCTCGA	0.463000										TSP Lung(15;0.13)			17	45					8.34094e-07	8.70022e-07	1	1	0
TRDN	10345	broad.mit.edu	37	6	123600201	123600201	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:123600201G>A	ENST00000334268.4	-	25	1854	c.1537_splice	c.e25+1	p.Q513_splice	TRDN_ENST00000398178.3_Splice_Site_p.Q513_splice			Q13061	TRDN_HUMAN	triadin	513					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		TATAACATACGTGGAGGTTTA	0.269000													16	27					0	0	1	0	0
LDB3	11155	broad.mit.edu	37	10	88476313	88476313	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:88476313T>C	ENST00000429277.2	+	10	1621	c.1476T>C	c.(1474-1476)cgT>cgC	p.R492R	LDB3_ENST00000352360.5_Silent_p.R230R|LDB3_ENST00000361373.4_Silent_p.R487R|LDB3_ENST00000263066.6_Silent_p.R377R|LDB3_ENST00000458213.2_Silent_p.R377R	NM_001171610.1	NP_001165081.1	O75112	LDB3_HUMAN	LIM domain binding 3	487						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|soft_tissue(1)	25						CTGCCAGCCGTCCACCCTGGG	0.662000													37	49					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4873895	4873895	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4873895G>A	ENST00000321919.9	-	6	627	c.551C>T	c.(550-552)cCg>cTg	p.P184L	GLYR1_ENST00000436648.5_Missense_Mutation_p.P103L|GLYR1_ENST00000381983.3_Missense_Mutation_p.P184L|GLYR1_ENST00000586901.1_5'UTR|GLYR1_ENST00000591451.1_Missense_Mutation_p.P184L	NM_032569.3	NP_115958.2	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	184					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						ACTAGACTCCGGGATGGTGAG	0.537000													22	67					0	0	1	0	0
ZNF793	390927	broad.mit.edu	37	19	38028666	38028666	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38028666G>A	ENST00000445217.1	+	4	1141	c.1106G>A	c.(1105-1107)tGc>tAc	p.C369Y	ZNF793_ENST00000587143.1_Missense_Mutation_p.C369Y|ZNF793_ENST00000589319.1_Intron|ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000542455.1_Missense_Mutation_p.C369Y			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCCTATGGGTGCAATGAATGT	0.428000													17	28					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79589981	79589981	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:79589981C>T	ENST00000372391.2	-	11	2008	c.2003G>A	c.(2002-2004)cGc>cAc	p.R668H	DLG5_ENST00000372388.2_Missense_Mutation_p.R668H	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	668	PDZ 1.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TTACCTTAAGCGGCCATCAGC	0.542000													13	22					0	0	1	0	0
RABL3	285282	broad.mit.edu	37	3	120424911	120424911	+	Missense_Mutation	SNP	G	G	A	rs144478835		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:120424911G>A	ENST00000273375.3	-	4	348	c.319C>T	c.(319-321)Cgt>Tgt	p.R107C	RABL3_ENST00000491398.1_5'UTR|RABL3_ENST00000483733.1_Missense_Mutation_p.R107C	NM_173825.3	NP_776186.2	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3	107	Small GTPase-like.				small GTPase mediated signal transduction		GTP binding	p.R107C(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)	17				GBM - Glioblastoma multiforme(114;0.151)		GACCAACGACGCAAGTTTTGG	0.383000													8	45					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372317	126372317	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:126372317A>G	ENST00000394329.3	+	9	10159	c.10146A>G	c.(10144-10146)agA>agG	p.R3382R	FAT4_ENST00000335110.5_Silent_p.R1680R	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3382	Cadherin 32.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCAGCATTAGAGGTGCAGATA	0.403000													49	75					0	0	1	0	0
ZNF768	79724	broad.mit.edu	37	16	30537189	30537189	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30537189G>T	ENST00000380412.5	-	2	447	c.272C>A	c.(271-273)cCt>cAt	p.P91H	ZNF768_ENST00000562803.1_Missense_Mutation_p.P60H	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	91	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						CACAAGCCCAGGGCTTCGGGA	0.567000													24	40					4.72057e-08	4.96844e-08	1	1	0
ZNF182	7569	broad.mit.edu	37	X	47836866	47836866	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:47836866C>T	ENST00000396965.1	-	7	970	c.620G>A	c.(619-621)gGc>gAc	p.G207D	ZNF182_ENST00000376943.3_Missense_Mutation_p.G188D|ZNF182_ENST00000305127.6_Missense_Mutation_p.G207D	NM_001178099.1	NP_001171570.1	P17025	ZN182_HUMAN	zinc finger protein 182	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)	22						CTCTTTATAGCCATAGGGCTT	0.368000													8	35					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65396390	65396390	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65396390G>A	ENST00000355703.3	+	24	4451	c.3912G>A	c.(3910-3912)cgG>cgA	p.R1304R		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1304						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CCTACGCTCGGCCCCTCAAGT	0.632000													3	20					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600325	29600325	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:29600325G>A	ENST00000431530.3	+	1	1578	c.1520G>A	c.(1519-1521)cGg>cAg	p.R507Q		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	497						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TCAGAAGCACGGGAAAGCAAA	0.488000													8	17					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30573700	30573700	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30573700G>A	ENST00000376511.2	-	10	1405	c.853_splice	c.e10+1	p.P285_splice		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	285	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						TTAGACTCACGCTGTGGCGGG	0.458000													6	190					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640133	179640133	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179640133G>A	ENST00000589042.1	-	28	6682	c.6458C>T	c.(6457-6459)gCc>gTc	p.A2153V	TTN_ENST00000342175.6_Missense_Mutation_p.A2107V|TTN_ENST00000360870.5_Missense_Mutation_p.A2153V|TTN_ENST00000591111.1_Missense_Mutation_p.A2153V|TTN_ENST00000460472.2_Missense_Mutation_p.A2107V|TTN_ENST00000342992.6_Missense_Mutation_p.A2153V|TTN_ENST00000359218.5_Missense_Mutation_p.A2107V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1914	Ig-like 10.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATGTTGATGGCTTTTACCAT	0.448000													9	39					0	0	1	0	0
DLGAP4	22839	broad.mit.edu	37	20	35060648	35060648	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:35060648C>T	ENST00000373913.3	+	3	1008	c.528C>T	c.(526-528)gaC>gaT	p.D176D	DLGAP4_ENST00000373907.2_Silent_p.D176D|DLGAP4_ENST00000401952.2_Silent_p.D176D|DLGAP4_ENST00000339266.5_Silent_p.D176D			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	176					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				GCATGGAGGACGGCAAGGGCC	0.642000													15	21					0	0	1	0	0
NR4A3	0	broad.mit.edu	37	9	102590329	102590329	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:102590329C>T	ENST00000330847.1	+	2	82	c.38C>T	c.(37-39)cCc>cTc	p.P13L	NR4A3_ENST00000395097.2_Missense_Mutation_p.P2L|NR4A3_ENST00000338488.4_Missense_Mutation_p.P2L			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	2					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				GCAGATATGCCCTGCGTCCAA	0.512000			T	EWSR1	extraskeletal myxoid chondrosarcoma								19	34					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134163074	134163074	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:134163074G>A	ENST00000389887.5	+	9	3343	c.847G>A	c.(847-849)Gat>Aat	p.D283N	GLB1L3_ENST00000431683.2_Missense_Mutation_p.D283N			Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	283					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		ACTTCACCAGGATACTTTCAA	0.473000													8	16					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55814126	55814126	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55814126C>T	ENST00000309383.1	+	10	1196	c.919C>T	c.(919-921)Cgg>Tgg	p.R307W	BRSK1_ENST00000326848.7_Missense_Mutation_p.R2W|BRSK1_ENST00000585418.1_Missense_Mutation_p.R307W|BRSK1_ENST00000590333.1_Missense_Mutation_p.R323W	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	307					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GGTAGCCATGCGGAGCCTGCC	0.652000													8	63					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98373685	98373685	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:98373685G>T	ENST00000186436.5	-	41	5757	c.5529C>A	c.(5527-5529)ccC>ccA	p.P1843P		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1843						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						TGGAGGTGGAGGGAGCGTGAG	0.587000													14	26					0.000151284	0.000155038	1	1	0
GTF2IRD1	9569	broad.mit.edu	37	7	73927219	73927219	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:73927219C>T	ENST00000476977.1	+	3	1874	c.183C>T	c.(181-183)agC>agT	p.S61S	GTF2IRD1_ENST00000489094.1_3'UTR|GTF2IRD1_ENST00000424337.2_Silent_p.S61S|GTF2IRD1_ENST00000455841.2_Silent_p.S61S|GTF2IRD1_ENST00000265755.3_Silent_p.S61S			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	61						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						ACGATGAGAGCGCCTTTGTGG	0.612000													18	27					0	0	1	0	0
RHOG	391	broad.mit.edu	37	11	3849003	3849003	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3849003C>T	ENST00000351018.4	-	2	523	c.366G>A	c.(364-366)caG>caA	p.Q122Q	RHOG_ENST00000396979.1_Silent_p.Q122Q|RHOG_ENST00000533217.1_Silent_p.Q122Q|RHOG_ENST00000396978.1_Silent_p.Q122Q	NM_001665.3	NP_001656.2	P84095	RHOG_HUMAN	ras homolog family member G	122					actin cytoskeleton organization|activation of Rac GTPase activity|axon guidance|cell chemotaxis|platelet activation|positive regulation of cell proliferation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of transcription, DNA-dependent|Rac protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(2)	2		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0349)|LUSC - Lung squamous cell carcinoma(625;0.194)		GGGTGTCAGGCTGGGCTCTCA	0.652000													6	8					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62141351	62141351	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62141351A>G	ENST00000433197.2	-	10	1177	c.1082T>C	c.(1081-1083)cTg>cCg	p.L361P		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	361					activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						CTTACCTATCAGAAGCCAGTA	0.567000											OREG0024657	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	15					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125864270	125864270	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:125864270A>G	ENST00000392693.3	-	14	2686	c.2559T>C	c.(2557-2559)agT>agC	p.S853S	CDON_ENST00000263577.7_Silent_p.S853S|CDON_ENST00000531738.1_Silent_p.S230S	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	853	Fibronectin type-III 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		TGTTATTGTTACTTGATGGAA	0.343000													12	23					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9864204	9864204	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:9864204C>T	ENST00000256190.8	-	25	3361	c.3224G>A	c.(3223-3225)cGt>cAt	p.R1075H	RP11-1H15.2_ENST00000533659.1_RNA	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1075					myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CCATCCAGGACGATTTACTCT	0.363000													13	52					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	230020593	230020593	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:230020593C>T	ENST00000392054.3	-	3	550	c.211G>A	c.(211-213)Gcc>Acc	p.A71T	PID1_ENST00000409462.1_Intron|PID1_ENST00000392055.3_Missense_Mutation_p.A40T|PID1_ENST00000482518.2_5'UTR|PID1_ENST00000354069.6_Missense_Mutation_p.A73T	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	73						cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		AGCTCAATGGCCTCCGGCTCA	0.512000													11	45					0	0	1	0	0
DDB1	1642	broad.mit.edu	37	11	61079290	61079290	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61079290C>T	ENST00000301764.7	-	18	2640	c.2243G>A	c.(2242-2244)gGc>gAc	p.G748D	DDB1_ENST00000450997.2_Intron	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	748	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						GGCTGTCGTGCCCCCACTCGT	0.562000								Nucleotide excision repair (NER)					10	21					0	0	1	0	0
CPNE8	144402	broad.mit.edu	37	12	39155959	39155959	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:39155959G>A	ENST00000331366.5	-	9	731	c.635C>T	c.(634-636)gCa>gTa	p.A212V	CPNE8_ENST00000360449.3_Missense_Mutation_p.A200V	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	212	C2 2.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				GATCTTGAATGCTTGCCATAC	0.308000													12	13					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	80164184	80164184	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:80164184C>T	ENST00000281127.7	+	4	1692	c.813C>T	c.(811-813)acC>acT	p.T271T	NRXN3_ENST00000335750.5_Silent_p.T903T|NRXN3_ENST00000554719.1_Silent_p.T903T|NRXN3_ENST00000557594.1_Silent_p.T271T|RP11-242P2.1_ENST00000553322.1_RNA|NRXN3_ENST00000556003.1_Intron|NRXN3_ENST00000428277.2_Silent_p.T301T	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	271					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CACAGACGACCTCCATGCCAC	0.468000													29	48					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551573	35551573	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35551573C>T	ENST00000262626.2	+	9	1488	c.663C>T	c.(661-663)gcC>gcT	p.A221A	HPN_ENST00000392226.1_Silent_p.A221A|HPN_ENST00000597419.1_Silent_p.A63A|HPN-AS1_ENST00000392227.2_RNA	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	221	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity	p.A221A(1)		central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	TTGCCGGTGCCGTGGCCCAGG	0.677000													4	31					0	0	1	0	0
MESDC1	59274	broad.mit.edu	37	15	81295606	81295606	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:81295606G>A	ENST00000267984.2	+	1	2312	c.994G>A	c.(994-996)Gcc>Acc	p.A332T		NM_022566.2	NP_072088.1	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	332										endometrium(1)|lung(2)	3						CTCGGCCTGCGCCGTGTCTGA	0.612000													3	4					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11772057	11772057	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:11772057C>T	ENST00000381486.2	+	27	4934	c.4634C>T	c.(4633-4635)cCg>cTg	p.P1545L	GREB1_ENST00000234142.5_Missense_Mutation_p.P1545L|GREB1_ENST00000396123.1_Missense_Mutation_p.P543L	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1545						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ATAAAAAGTCCGACATTCACT	0.463000													15	30					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86284631	86284631	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:86284631C>T	ENST00000394518.2	+	35	8058	c.7963C>T	c.(7963-7965)Cgt>Tgt	p.R2655C	AKAP13_ENST00000361243.2_Missense_Mutation_p.R2659C|AKAP13_ENST00000394510.2_Missense_Mutation_p.R900C|AKAP13_ENST00000560579.1_3'UTR	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2655	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GGAGCGACTGCGTGCTGCCCA	0.632000													9	15					0	0	1	0	0
GLUD1	2746	broad.mit.edu	37	10	88820713	88820713	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:88820713G>T	ENST00000277865.4	-	7	1114	c.1018C>A	c.(1018-1020)Cca>Aca	p.P340T	GLUD1_ENST00000465164.1_5'UTR|GLUD1_ENST00000544149.1_Missense_Mutation_p.P207T|GLUD1_ENST00000537649.1_Missense_Mutation_p.P173T	NM_005271.3	NP_005262.1	P00367	DHE3_HUMAN	glutamate dehydrogenase 1	340					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(11)|prostate(1)	22					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATACCATCTGGATTCCATATA	0.358000													74	137					2.22156e-40	2.49648e-40	1	1	0
PIK3C2G	5288	broad.mit.edu	37	12	18552761	18552761	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:18552761T>C	ENST00000433979.1	+	15	2288	c.2172T>C	c.(2170-2172)gcT>gcC	p.A724A	PIK3C2G_ENST00000538779.1_Silent_p.A765A|PIK3C2G_ENST00000266497.5_Silent_p.A724A	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	724					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				CTTTAGAGGCTCTTGGGCTTT	0.388000													11	11					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104312963	104312963	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:104312963G>A	ENST00000389120.3	+	10	1258	c.1168G>A	c.(1168-1170)Gtc>Atc	p.V390I		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	390					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		ACAGTTCTCCGTCTTGTATAA	0.512000													49	80					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48264351	48264351	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:48264351G>A	ENST00000394747.1	-	2	582	c.233C>T	c.(232-234)cCg>cTg	p.P78L	ABCC11_ENST00000353782.5_Missense_Mutation_p.P78L|ABCC11_ENST00000394748.1_Missense_Mutation_p.P78L|ABCC11_ENST00000356608.2_Missense_Mutation_p.P78L|ABCC11_ENST00000537808.1_Missense_Mutation_p.P78L	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	78						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.P78L(1)		breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GACTCACCTCGGCTTGGGACG	0.572000													8	11					0	0	1	0	0
CORO1B	57175	broad.mit.edu	37	11	67206326	67206326	+	Missense_Mutation	SNP	G	G	A	rs149833628		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67206326G>A	ENST00000393893.1	-	11	1263	c.1160C>T	c.(1159-1161)cCg>cTg	p.P387L	CORO1B_ENST00000539724.1_5'UTR|CORO1B_ENST00000341356.5_Missense_Mutation_p.P387L	NM_001018070.2	NP_001018080.1	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	387					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			GATGAGGATCGGGTCGGCATC	0.682000													4	12					0	0	1	0	0
KCNMB2	10242	broad.mit.edu	37	3	178560711	178560711	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:178560711C>T	ENST00000432997.1	+	5	1046	c.694C>T	c.(694-696)Cgg>Tgg	p.R232W	KCNMB2_ENST00000452583.1_Missense_Mutation_p.R232W|RP11-385J1.2_ENST00000437488.1_RNA|KCNMB2_ENST00000420517.2_Missense_Mutation_p.R232W|RP11-385J1.2_ENST00000451742.1_RNA|RP11-385J1.2_ENST00000432385.1_RNA|RP11-385J1.2_ENST00000425330.1_RNA|KCNMB2_ENST00000358316.3_Missense_Mutation_p.R232W	NM_005832.3	NP_005823.1	Q9Y691	KCMB2_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 2	232					detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity	p.R232W(1)		NS(2)|endometrium(4)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	12	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			GAGGATCCAACGGATCAATAG	0.383000													22	24					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125449047	125449047	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:125449047G>A	ENST00000308736.2	-	15	2036	c.1938C>T	c.(1936-1938)taC>taT	p.Y646Y	DHX37_ENST00000544745.1_Silent_p.Y433Y	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	646	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TGACGCGGTCGTAGTAGCGTT	0.617000													17	22					0	0	1	0	0
LGALS4	3960	broad.mit.edu	37	19	39299546	39299546	+	Silent	SNP	G	G	A	rs148221331		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39299546G>A	ENST00000307751.4	-	3	654	c.177C>T	c.(175-177)gaC>gaT	p.D59D	LGALS4_ENST00000597803.1_Intron	NM_006149.3	NP_006140.1	P56470	LEG4_HUMAN	lectin, galactoside-binding, soluble, 4	59	Galectin 1.				cell adhesion	cytosol|plasma membrane	sugar binding			NS(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	17	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GGAAGGCGACGTCTGAGCCCG	0.632000													8	12					0	0	1	0	0
EGFL6	25975	broad.mit.edu	37	X	13635866	13635866	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:13635866G>A	ENST00000361306.1	+	8	1053	c.796G>A	c.(796-798)Gtg>Atg	p.V266M	EGFL6_ENST00000380602.3_Missense_Mutation_p.V266M	NM_001167890.1|NM_015507.3	NP_001161362.1|NP_056322.2	Q8IUX8	EGFL6_HUMAN	EGF-like-domain, multiple 6	266					cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)|skin(3)	23						TGAAAATTCTGTGAAGGAAGT	0.333000													30	36					0	0	1	0	0
PRRG3	79057	broad.mit.edu	37	X	150869494	150869494	+	Missense_Mutation	SNP	G	G	A	rs1106194	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:150869494G>A	ENST00000370353.3	+	4	1075	c.685G>A	c.(685-687)Gct>Act	p.A229T	PRRG3_ENST00000538575.1_Missense_Mutation_p.A229T			Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)	229						extracellular region|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					CAACCCTGGCGCTGACAAGTA	0.542000													18	2					0	0	1	0	0
IGLV1-51	0	broad.mit.edu	37	22	22677099	22677099	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:22677099G>A	ENST00000390290.2	+	0	163				LL22NC03-80A10.6_ENST00000426066.1_RNA																							CTCCTGCTCTGGAAGCAGCTC	0.552000													67	65					0	0	1	0	0
HMGXB4	10042	broad.mit.edu	37	22	35660803	35660803	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:35660803C>T	ENST00000216106.5	+	5	550	c.422C>T	c.(421-423)tCg>tTg	p.S141L	HMGXB4_ENST00000444518.2_Missense_Mutation_p.S32L	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	141					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TCAAGCCATTCGGAGAGTAAA	0.502000													27	38					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99110082	99110082	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:99110082G>A	ENST00000394170.2	+	3	672	c.421G>A	c.(421-423)Gcc>Acc	p.A141T	ZKSCAN5_ENST00000326775.5_Missense_Mutation_p.A141T|ZKSCAN5_ENST00000451158.1_Missense_Mutation_p.A141T	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	141					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TTAGATTGTTGCCTGCCCTGA	0.522000													35	50					0	0	1	0	0
MYO6	4646	broad.mit.edu	37	6	76568665	76568665	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:76568665C>T	ENST00000369981.3	+	14	1707	c.1428C>T	c.(1426-1428)tgC>tgT	p.C476C	MYO6_ENST00000369975.1_Silent_p.C476C|MYO6_ENST00000369985.4_Silent_p.C476C|MYO6_ENST00000369977.3_Silent_p.C476C			Q9UM54	MYO6_HUMAN	myosin VI	476	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		TCAACTATTGCAATGAAAAAC	0.264000													5	33					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183861295	183861295	+	Splice_Site	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:183861295G>T	ENST00000304685.3	+	10	1706	c.1245_splice	c.e10+1	p.K415_splice	RGL1_ENST00000360851.3_Splice_Site_p.K380_splice|RGL1_ENST00000539189.1_Splice_Site_p.K380_splice|RGL1_ENST00000536277.1_Splice_Site_p.K378_splice|RGL1_ENST00000367531.1_Splice_Site_p.K415_splice	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	380	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						TACTGATGAAGGTGAGGCTCT	0.433000													5	30					2.7689e-08	2.91998e-08	1	1	0
RP1-274L7.1	0	broad.mit.edu	37	X	129629816	129629816	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:129629816G>T	ENST00000458525.1	-	0	1015				FAM45B_ENST00000592932.1_RNA																							AAGCCCTGCAGATGTGCACAG	0.537000													16	31					1.67942e-08	1.77343e-08	1	1	0
PTN	5764	broad.mit.edu	37	7	136939648	136939648	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:136939648C>T	ENST00000348225.2	-	2	500	c.73G>A	c.(73-75)Gca>Aca	p.A25T	PTN_ENST00000393083.2_Missense_Mutation_p.A25T	NM_002825.5	NP_002816.1	P21246	PTN_HUMAN	pleiotrophin	25					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23						TCCACAGCTGCCAGTATGAAA	0.443000													24	55					0	0	1	0	0
SAMD4A	23034	broad.mit.edu	37	14	55236928	55236928	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:55236928G>A	ENST00000251091.5	+	7	1744	c.1439G>A	c.(1438-1440)cGa>cAa	p.R480Q	SAMD4A_ENST00000555192.1_Missense_Mutation_p.R159Q|SAMD4A_ENST00000554335.1_Missense_Mutation_p.R568Q|SAMD4A_ENST00000357634.3_Missense_Mutation_p.R567Q|SAMD4A_ENST00000392067.3_Missense_Mutation_p.R568Q	NM_001161576.2	NP_001155048.2	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4A	568					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)	29						TCAGGATATCGACAGCAAAGA	0.468000													5	110					0	0	1	0	0
RTKN	6242	broad.mit.edu	37	2	74653438	74653438	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:74653438G>A	ENST00000305557.5	-	13	2170	c.1585C>T	c.(1585-1587)Cga>Tga	p.R529*	RTKN_ENST00000272430.5_Nonsense_Mutation_p.R542*|RTKN_ENST00000233330.6_Nonsense_Mutation_p.R492*	NM_033046.2	NP_149035.1	Q9BST9	RTKN_HUMAN	rhotekin	542	Pro-rich.				apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			endometrium(3)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	16						CGTGGGGATCGCTGAGGTGGG	0.652000													31	55					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44575866	44575866	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44575866A>G	ENST00000289547.4	-	4	1898	c.1843T>C	c.(1843-1845)Ttc>Ctc	p.F615L	NPC1L1_ENST00000381160.3_Missense_Mutation_p.F615L|NPC1L1_ENST00000423141.1_Missense_Mutation_p.F615L|NPC1L1_ENST00000546276.1_Missense_Mutation_p.F615L	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	615					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	TCAGCCATGAACGTGACCTGG	0.652000													8	43					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80223162	80223162	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:80223162G>A	ENST00000392959.1	-	4	1098	c.487C>T	c.(487-489)Cgt>Tgt	p.R163C	LCA5_ENST00000369846.4_Missense_Mutation_p.R163C|LCA5_ENST00000467898.2_Missense_Mutation_p.R163C	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	163					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TTGTTATGACGAAATATAAGT	0.353000													5	91					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111216459	111216459	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:111216459G>A	ENST00000369769.2	-	1	1196	c.973C>T	c.(973-975)Cga>Tga	p.R325*		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	325						voltage-gated potassium channel complex	delayed rectifier potassium channel activity	p.R325*(1)		endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATGATGTTTCGCGAGAAGGTG	0.532000													11	47					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64415277	64415277	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:64415277T>C	ENST00000395251.1	+	4	611	c.277T>C	c.(277-279)Tcc>Ccc	p.S93P	ZNF365_ENST00000395249.1_Intron|ZNF365_ENST00000410046.3_Intron	NM_199452.3	NP_955524.3	Q70YC4	TALAN_HUMAN	zinc finger protein 365	93										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					CTCATCAGCATCCCCCTGGCC	0.542000													24	24					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413601	105413601	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105413601C>T	ENST00000333244.5	-	7	8306	c.8187G>A	c.(8185-8187)ggG>ggA	p.G2729G	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2729						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGGGCAGGTGCCCTTTGAGGC	0.617000													90	109					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28414705	28414705	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28414705A>G	ENST00000261609.7	-	66	10262	c.10154T>C	c.(10153-10155)tTg>tCg	p.L3385S		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3385					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATCCAATGACAAGAGAATCTT	0.418000													24	38					0	0	1	0	0
HOXC12	3228	broad.mit.edu	37	12	54350229	54350229	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:54350229G>A	ENST00000243103.3	+	2	824	c.728G>A	c.(727-729)cGc>cAc	p.R243H		NM_173860.1	NP_776272.1	P31275	HXC12_HUMAN	homeobox C12	243					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)	12						ACACGCCAGCGCCGGAGGGAA	0.522000													35	43					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34243008	34243008	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:34243008C>T	ENST00000374114.3	-	3	500	c.237G>A	c.(235-237)atG>atA	p.M79I	CPNE1_ENST00000352393.4_Intron|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000397442.1_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.M79I|CPNE1_ENST00000397443.1_Intron|RBM12_ENST00000359646.1_Missense_Mutation_p.M79I|CPNE1_ENST00000397445.1_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	79						nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TCATATTCTGCATTTCCGTCT	0.428000											OREG0004046	type=REGULATORY REGION|Gene=RBM12|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	26	43					0	0	1	0	0
YME1L1	10730	broad.mit.edu	37	10	27423040	27423040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:27423040G>A	ENST00000326799.3	-	8	1022	c.874C>T	c.(874-876)Cga>Tga	p.R292*	YME1L1_ENST00000375972.3_Nonsense_Mutation_p.R202*|YME1L1_ENST00000376016.3_Nonsense_Mutation_p.R235*|YME1L1_ENST00000463270.1_5'UTR	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	292					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						AGACGGGTTCGCCTTAGGGAA	0.323000													16	15					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158290895	158290895	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:158290895C>T	ENST00000264192.3	-	3	387	c.266G>A	c.(265-267)gGa>gAa	p.G89E	CYTIP_ENST00000540637.1_5'UTR|CYTIP_ENST00000497432.1_5'UTR	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	89	PDZ.				regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						AATTTCAAATCCAAATGTTTC	0.338000													16	31					0	0	1	0	0
COX15	1355	broad.mit.edu	37	10	101486888	101486888	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:101486888G>A	ENST00000370483.5	-	4	469	c.419C>T	c.(418-420)aCa>aTa	p.T140I	CUTC_ENST00000493385.1_Intron|COX15_ENST00000016171.5_Missense_Mutation_p.T140I	NM_004376.5|NM_078470.4	NP_004367.2|NP_510870.1	Q7KZN9	COX15_HUMAN	cytochrome c oxidase assembly homolog 15 (yeast)	140					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		CTTGAATTCTGTCAGTGTCAT	0.433000													7	23					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37367742	37367742	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:37367742G>T	ENST00000361924.2	+	14	4739	c.4365G>T	c.(4363-4365)caG>caT	p.Q1455H	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.Q1477H	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1455	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GATTTACACAGCATCAAAACA	0.363000													20	46					3.51602e-12	3.7986e-12	1	1	0
A4GALT	53947	broad.mit.edu	37	22	43089480	43089480	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:43089480C>T	ENST00000401850.1	-	2	967	c.478G>A	c.(478-480)Gcg>Acg	p.A160T	A4GALT_ENST00000249005.2_Missense_Mutation_p.A160T|A4GALT_ENST00000381278.3_Missense_Mutation_p.A160T			Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	160					glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			NS(1)|central_nervous_system(2)|large_intestine(6)|skin(1)|urinary_tract(1)	11						TGCACGGCCGCGTACCAGTCG	0.662000													13	35					0	0	1	0	0
MEIS2	4212	broad.mit.edu	37	15	37184601	37184601	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:37184601C>T	ENST00000338564.5	-	13	1632	c.1186G>A	c.(1186-1188)Gca>Aca	p.A396T	MEIS2_ENST00000382766.2_Missense_Mutation_p.A396T|MEIS2_ENST00000561208.1_Missense_Mutation_p.A403T|MEIS2_ENST00000397624.3_3'UTR|MEIS2_ENST00000340545.5_3'UTR|MEIS2_ENST00000397620.2_3'UTR|MEIS2_ENST00000219869.9_3'UTR|MEIS2_ENST00000424352.2_3'UTR|MEIS2_ENST00000444725.1_3'UTR|MEIS2_ENST00000559085.1_3'UTR|MEIS2_ENST00000557796.2_3'UTR	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	403					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		CTTGGCTGTGCCATACTCATT	0.502000													8	155					0	0	1	0	0
NUCB1	4924	broad.mit.edu	37	19	49416276	49416276	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49416276G>A	ENST00000405315.4	+	6	823	c.489G>A	c.(487-489)cgG>cgA	p.R163R	NUCB1_ENST00000407032.1_Silent_p.R163R|NUCB1_ENST00000485798.1_Intron|NUCB1-AS1_ENST00000416432.1_RNA|NUCB1_ENST00000263273.5_Silent_p.R163R	NM_006184.5	NP_006175.2	Q02818	NUCB1_HUMAN	nucleobindin 1	163						ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding			cervix(1)|endometrium(4)|large_intestine(4)|lung(8)	17		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		AGGCCACCCGGGACCTTGCCC	0.607000													8	22					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11269467	11269467	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:11269467G>A	ENST00000361445.4	-	25	3779	c.3703C>T	c.(3703-3705)Cgg>Tgg	p.R1235W		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1235					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CTAAGCATCCGATGCTGGTAA	0.473000													68	93					0	0	1	0	0
DHRSX	207063	broad.mit.edu	37	X	2184850	2184850	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:2184850G>A	ENST00000334651.5	-	5	579	c.527C>T	c.(526-528)gCg>gTg	p.A176V	DHRSX_ENST00000464935.1_5'UTR	NM_145177.2	NP_660160.2	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	176							binding|oxidoreductase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)	16		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GACCACCCTCGCACTGTGGCC	0.542000													51	152					0	0	1	0	0
THRA	7067	broad.mit.edu	37	17	38244645	38244645	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:38244645C>A	ENST00000450525.2	+	8	1365	c.874C>A	c.(874-876)Ctg>Atg	p.L292M	THRA_ENST00000584985.1_Missense_Mutation_p.L292M|THRA_ENST00000546243.1_Missense_Mutation_p.L292M|THRA_ENST00000394121.4_Missense_Mutation_p.L292M|THRA_ENST00000264637.4_Missense_Mutation_p.L292M	NM_199334.3	NP_955366.1	P10827	THA_HUMAN	thyroid hormone receptor, alpha	292	Ligand-binding.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)	11	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	GAATGGCGGCCTGGGCGTAGT	0.607000													54	53					1.11015e-26	1.241e-26	1	1	0
PTGIS	5740	broad.mit.edu	37	20	48129687	48129687	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:48129687C>T	ENST00000244043.4	-	8	1165	c.1136G>A	c.(1135-1137)cGt>cAt	p.R379H	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	379			R -> S (in allele CYP8A1*4; dbSNP:rs56195291).		hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	GCGGTCACCACGTCGCAGGTT	0.612000													19	36					0	0	1	0	0
BTD	686	broad.mit.edu	37	3	15686298	15686298	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:15686298G>A	ENST00000383778.4	+	4	1233	c.875G>A	c.(874-876)gGc>gAc	p.G292D	BTD_ENST00000303498.5_Missense_Mutation_p.G312D|BTD_ENST00000449107.1_Missense_Mutation_p.G314D|BTD_ENST00000437172.1_Missense_Mutation_p.G314D			P43251	BTD_HUMAN	biotinidase	312	CN hydrolase.				central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	18						ACAGGAAGTGGCATACACACC	0.478000													7	88					0	0	1	0	0
GIGYF1	64599	broad.mit.edu	37	7	100282479	100282479	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:100282479G>A	ENST00000275732.5	-	12	2538	c.1329C>T	c.(1327-1329)tcC>tcT	p.S443S	GIGYF1_ENST00000471340.2_5'UTR	NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	443										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CCTCCTCCAAGGAGCTGTCCT	0.632000													7	5					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1918645	1918645	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1918645G>A	ENST00000503128.1	+	4	1015	c.808G>A	c.(808-810)Gcc>Acc	p.A270T	WHSC1_ENST00000382895.3_Missense_Mutation_p.A270T|WHSC1_ENST00000508803.1_Missense_Mutation_p.A270T|WHSC1_ENST00000382891.5_Missense_Mutation_p.A270T|WHSC1_ENST00000382892.2_Missense_Mutation_p.A270T|WHSC1_ENST00000398261.1_Missense_Mutation_p.A270T|WHSC1_ENST00000420906.2_Missense_Mutation_p.A270T|WHSC1_ENST00000514045.1_Missense_Mutation_p.A270T			O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	270	PWWP 1.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CTTTGGTGACGCCCCAGAAAG	0.418000			T	IGH@	MM								5	96					0	0	1	0	0
MMS22L	253714	broad.mit.edu	37	6	97613176	97613176	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:97613176G>A	ENST00000275053.4	-	21	3432	c.3167C>T	c.(3166-3168)aCa>aTa	p.T1056I	MMS22L_ENST00000369251.2_Missense_Mutation_p.T1016I	NM_198468.2	NP_940870.2	Q6ZRQ5	MMS22_HUMAN	MMS22-like, DNA repair protein	1056					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding			breast(1)|endometrium(9)|kidney(2)|large_intestine(12)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	50						AATAGTGGCTGTGTTTCTCAA	0.363000													28	32					0	0	1	0	0
CCDC171	203238	broad.mit.edu	37	9	15778980	15778980	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:15778980G>A	ENST00000380701.3	+	20	3241	c.2913G>A	c.(2911-2913)tcG>tcA	p.S971S	CCDC171_ENST00000297641.3_Silent_p.S971S	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	971																	GCACAGCATCGTTGCAGAAGC	0.368000													24	44					0	0	1	0	0
LEMD2	221496	broad.mit.edu	37	6	33744944	33744944	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33744944G>A	ENST00000293760.5	-	7	1248	c.1229C>T	c.(1228-1230)gCc>gTc	p.A410V	LEMD2_ENST00000502643.1_5'UTR|LEMD2_ENST00000508327.1_Missense_Mutation_p.A108V	NM_181336.3	NP_851853.1	Q8NC56	LEMD2_HUMAN	LEM domain containing 2	410						integral to nuclear inner membrane				central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(2)|pancreas(1)	9						CTCATACATGGCTTGTTCCTC	0.498000													18	270					0	0	1	0	0
UGT2B7	7364	broad.mit.edu	37	4	69978269	69978269	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:69978269C>T	ENST00000305231.7	+	6	1451	c.1405C>T	c.(1405-1407)Cgc>Tgc	p.R469C	UGT2B7_ENST00000508661.1_3'UTR|UGT2B7_ENST00000509763.1_3'UTR	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	469					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						ATTTGTCATGCGCCACAAAGG	0.463000													71	94					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75981312	75981312	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75981312G>A	ENST00000308508.5	-	3	2186	c.2094C>T	c.(2092-2094)agC>agT	p.S698S		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	698	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GGAACAGCACGCTCACATCCT	0.667000													27	37					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19996934	19996934	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:19996934C>A	ENST00000391403.2	-	1	944	c.841G>T	c.(841-843)Gga>Tga	p.G281*		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	281						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TTCAAAGCTCCTTTTGGAGGA	0.343000													16	69					1.3612e-06	1.41782e-06	1	1	0
AZU1	566	broad.mit.edu	37	19	828253	828253	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:828253G>A	ENST00000233997.2	+	2	103	c.82G>A	c.(82-84)Gtt>Att	p.V28I		NM_001700.3	NP_001691.1	P20160	CAP7_HUMAN	azurocidin 1	28	Peptidase S1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			NS(1)|endometrium(1)|kidney(1)|lung(4)|pancreas(1)|upper_aerodigestive_tract(2)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTGGACATCGTTGGCGGCCG	0.652000													26	45					0	0	1	0	0
SELRC1	65260	broad.mit.edu	37	1	53153624	53153624	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:53153624G>A	ENST00000371538.3	-	3	503	c.464C>T	c.(463-465)gCc>gTc	p.A155V	SELRC1_ENST00000486918.1_5'UTR	NM_023077.2	NP_075565.2	Q96BR5	SELR1_HUMAN	Sel1 repeat containing 1	155							binding			breast(1)|lung(3)|prostate(1)|urinary_tract(1)	6						CAGGAACATGGCACTGAGGTT	0.547000													16	41					0	0	1	0	0
SKA3	221150	broad.mit.edu	37	13	21746495	21746495	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:21746495C>T	ENST00000314759.5	-	3	438	c.314G>A	c.(313-315)cGt>cAt	p.R105H	SKA3_ENST00000400018.3_Missense_Mutation_p.R105H	NM_145061.5	NP_659498.4	Q8IX90	SKA3_HUMAN	spindle and kinetochore associated complex subunit 3	105					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						TTTCTTGACACGTGGACTATA	0.313000													31	59					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39046072	39046072	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:39046072G>A	ENST00000295373.6	-	19	3544	c.3418C>T	c.(3418-3420)Cgt>Tgt	p.R1140C		NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1140							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TAACTTGCACGCACGCCTTCT	0.383000													4	82					0	0	1	0	0
ARID5A	10865	broad.mit.edu	37	2	97216922	97216922	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:97216922G>T	ENST00000454558.2	+	7	1630	c.453G>T	c.(451-453)caG>caT	p.Q151H	ARID5A_ENST00000357485.3_Missense_Mutation_p.Q219H			Q03989	ARI5A_HUMAN	AT rich interactive domain 5A (MRF1-like)	219					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						CAGAACAGCAGGGCCTGGCCT	0.592000													24	36					6.12954e-19	6.77144e-19	1	1	0
NPY1R	0	broad.mit.edu	37	4	164247165	164247165	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:164247165T>C	ENST00000296533.2	-	2	1073	c.542A>G	c.(541-543)gAt>gGt	p.D181G	NPY1R_ENST00000509586.1_Intron	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	181					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GAACGGCTCATCAGTCATTAC	0.413000													13	31					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102476656	102476656	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:102476656G>A	ENST00000360184.4	+	31	6429	c.6265G>A	c.(6265-6267)Ggt>Agt	p.G2089S		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2089	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TTATGACTTCGGTCTTCGGGC	0.423000													24	52					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49435269	49435269	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49435269C>T	ENST00000301067.7	-	31	6283	c.6284G>A	c.(6283-6285)cGt>cAt	p.R2095H		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GTCAGTCTTACGGGCTATGTC	0.662000													23	41					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185169094	185169094	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:185169094C>T	ENST00000265026.3	+	7	1523	c.1189C>T	c.(1189-1191)Cga>Tga	p.R397*	MAP3K13_ENST00000424227.1_Nonsense_Mutation_p.R397*|MAP3K13_ENST00000535426.1_Nonsense_Mutation_p.R253*|MAP3K13_ENST00000446828.1_Nonsense_Mutation_p.R190*|MAP3K13_ENST00000443863.1_Nonsense_Mutation_p.R253*	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	397	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding	p.R397*(1)		NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			ACCTCGAAACCGACCTTCTTT	0.398000													25	44					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109727693	109727693	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:109727693C>T	ENST00000369939.3	+	8	1162	c.979C>T	c.(979-981)Cgc>Tgc	p.R327C	KIAA1324_ENST00000529753.1_Intron	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	327					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CTGTAACGTGCGCCCAGCTTG	0.493000													5	123					0	0	1	0	0
AQP2	359	broad.mit.edu	37	12	50349238	50349238	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:50349238C>T	ENST00000199280.3	+	4	748	c.663C>T	c.(661-663)taC>taT	p.Y221Y	RP11-469H8.6_ENST00000552379.1_RNA|RP11-469H8.8_ENST00000552806.1_RNA|RP11-469H8.6_ENST00000550530.1_RNA	NM_000486.5	NP_000477.1	P41181	AQP2_HUMAN	aquaporin 2 (collecting duct)	221					cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(4)|ovary(2)	10						TCTACAACTACGTGCTGTTTC	0.706000													10	20					0	0	1	0	0
C9orf40	55071	broad.mit.edu	37	9	77563093	77563093	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:77563093G>T	ENST00000376854.5	-	2	730	c.456C>A	c.(454-456)acC>acA	p.T152T		NM_017998.2	NP_060468.2	Q8IXQ3	CI040_HUMAN	chromosome 9 open reading frame 40	152										lung(2)|stomach(1)	3						AGTACTGGAAGGTATTATACT	0.368000													25	31					1.5548e-18	1.71633e-18	1	1	0
GABRR1	2569	broad.mit.edu	37	6	89907817	89907817	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:89907817C>T	ENST00000435811.1	-	4	897	c.443G>A	c.(442-444)cGc>cAc	p.R148H	GABRR1_ENST00000369451.3_Missense_Mutation_p.R78H|GABRR1_ENST00000454853.2_Missense_Mutation_p.R165H	NM_001256703.1	NP_001243632.1	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 1	165					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(7)|lung(16)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	35		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	GATGAAGGAGCGTTTGGAGTG	0.517000													75	98					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3128661	3128661	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:3128661G>A	ENST00000263650.7	-	9	1050	c.891C>T	c.(889-891)aaC>aaT	p.N297N	OSBPL5_ENST00000348039.5_Silent_p.N229N|OSBPL5_ENST00000525498.1_Silent_p.N208N|OSBPL5_ENST00000542243.1_Intron|OSBPL5_ENST00000389989.3_Silent_p.N229N	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	297					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		AGAATGCATCGTTCTCCAGGG	0.607000													50	77					0	0	1	0	0
ARHGEF39	84904	broad.mit.edu	37	9	35662261	35662261	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35662261A>G	ENST00000378387.3	-	8	1024	c.907T>C	c.(907-909)Tcc>Ccc	p.S303P	ARHGEF39_ENST00000343259.3_Missense_Mutation_p.V183A|ARHGEF39_ENST00000490970.1_5'UTR|ARHGEF39_ENST00000378395.2_Missense_Mutation_p.S267P	NM_032818.2	NP_116207.2			Rho guanine nucleotide exchange factor (GEF) 39																		TGAGGGAAGGACAGCTAGAGA	0.512000													11	21					0	0	1	0	0
CNPY3	10695	broad.mit.edu	37	6	42903398	42903398	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:42903398G>A	ENST00000372836.4	+	3	733	c.362G>A	c.(361-363)cGa>cAa	p.R121Q	CNPY3_ENST00000394142.3_3'UTR	NM_006586.3	NP_006577.2	Q9BT09	CNPY3_HUMAN	canopy FGF signaling regulator 3	121	Saposin B-type.				innate immune response	endoplasmic reticulum				central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)	6	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			GGCAGCAATCGATTTGCCAAG	0.512000													22	17					0	0	1	0	0
CXorf56	63932	broad.mit.edu	37	X	118676491	118676491	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:118676491C>T	ENST00000320339.4	-	5	614	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	CXorf56_ENST00000476164.1_Missense_Mutation_p.E164K|CXorf56_ENST00000486230.1_Missense_Mutation_p.E164K|CXorf56_ENST00000536133.1_Missense_Mutation_p.E150K|CXorf56_ENST00000371594.4_Missense_Mutation_p.E164K|CXorf56_ENST00000469448.1_5'UTR	NM_001170569.1	NP_001164040.1	Q9H5V9	CX056_HUMAN	chromosome X open reading frame 56	164							protein binding			cervix(1)|endometrium(2)|lung(7)	10						TCTTCCTCTTCATCAATGGTA	0.507000													41	6					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141459810	141459810	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:141459810C>T	ENST00000389484.3	-	39	7173	c.6202G>A	c.(6202-6204)Gac>Aac	p.D2068N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2068					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTCTCAAGGTCGATTCTCTCT	0.408000										TSP Lung(27;0.18)			33	51					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31374388	31374388	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:31374388C>T	ENST00000328111.2	+	5	708	c.387C>T	c.(385-387)ggC>ggT	p.G129G	DNMT3B_ENST00000375623.4_Intron|DNMT3B_ENST00000344505.4_Silent_p.G129G|DNMT3B_ENST00000443239.3_Intron|DNMT3B_ENST00000456297.2_Intron|DNMT3B_ENST00000353855.2_Silent_p.G129G|DNMT3B_ENST00000201963.3_Silent_p.G141G|DNMT3B_ENST00000348286.2_Silent_p.G129G	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	129	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GCCGGCAGGGCCGCAACCATG	0.622000													19	20					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38154776	38154776	+	Missense_Mutation	SNP	G	G	A	rs145787730	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:38154776G>A	ENST00000379747.4	-	11	1568	c.1451C>T	c.(1450-1452)gCg>gTg	p.A484V	POSTN_ENST00000379742.4_Missense_Mutation_p.A484V|POSTN_ENST00000541481.1_Missense_Mutation_p.A484V|POSTN_ENST00000379743.4_Missense_Mutation_p.A484V|POSTN_ENST00000379749.4_Missense_Mutation_p.A484V|POSTN_ENST00000541179.1_Missense_Mutation_p.A484V	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	484	FAS1 3.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TATGTGAATCGCACCGTTTCT	0.443000													25	121					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79875065	79875065	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:79875065G>A	ENST00000360280.3	+	23	2612	c.2352G>A	c.(2350-2352)ggG>ggA	p.G784G	VPS13A_ENST00000357409.5_Silent_p.G784G|VPS13A_ENST00000376634.4_Silent_p.G784G|VPS13A_ENST00000376636.3_Silent_p.G784G	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	784					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						AACTACAAGGGATTATGGAAT	0.294000													34	42					0	0	1	0	0
DDX58	23586	broad.mit.edu	37	9	32457353	32457353	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:32457353T>C	ENST00000379882.1	-	17	2567	c.2410A>G	c.(2410-2412)Aag>Gag	p.K804E	DDX58_ENST00000379868.1_Missense_Mutation_p.K646E|DDX58_ENST00000542096.1_Missense_Mutation_p.K778E|DDX58_ENST00000379883.2_Missense_Mutation_p.K849E			O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	849	Repressor domain.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		TGCTTTGGCTTGGGATGTGGT	0.418000													19	50					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115366002	115366002	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:115366002A>G	ENST00000369358.4	-	33	4010	c.3766T>C	c.(3766-3768)Tat>Cat	p.Y1256H	NRAP_ENST00000360478.3_Missense_Mutation_p.Y1213H|NRAP_ENST00000359988.3_Missense_Mutation_p.Y1248H|NRAP_ENST00000369360.3_Missense_Mutation_p.Y1221H			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1248						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GTCATTGTATACTCGTGTCTT	0.443000													29	50					0	0	1	0	0
CSNK1E	1454	broad.mit.edu	37	22	38698877	38698877	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38698877C>T	ENST00000396832.1	-	4	585	c.325G>A	c.(325-327)Gcc>Acc	p.A109T	CSNK1E_ENST00000413574.2_Missense_Mutation_p.A109T|CSNK1E_ENST00000405675.3_Missense_Mutation_p.A109T|CSNK1E_ENST00000359867.3_Missense_Mutation_p.A109T|CSNK1E_ENST00000400206.2_Missense_Mutation_p.A109T|CSNK1E_ENST00000403904.1_Missense_Mutation_p.A109T	NM_152221.2	NP_689407.1	P49674	KC1E_HUMAN	casein kinase 1, epsilon	109	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Melanoma(58;0.045)					ATCTGGTCGGCCAAGAGCAGC	0.617000													22	26					0	0	1	0	0
ALAS1	211	broad.mit.edu	37	3	52239990	52239990	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:52239990C>A	ENST00000394965.2	+	7	1296	c.936C>A	c.(934-936)tgC>tgA	p.C312*	ALAS1_ENST00000310271.2_Nonsense_Mutation_p.C312*|ALAS1_ENST00000484952.1_Nonsense_Mutation_p.C312*|ALAS1_ENST00000469224.1_Nonsense_Mutation_p.C312*	NM_000688.5	NP_000679.1	P13196	HEM1_HUMAN	aminolevulinate, delta-, synthase 1	312					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			endometrium(3)|kidney(3)|large_intestine(7)|liver(2)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TTTCCTCGTGCTTTGTGGCCA	0.473000													34	45					6.05902e-23	6.74593e-23	1	1	0
TMEM200A	114801	broad.mit.edu	37	6	130761877	130761877	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:130761877G>A	ENST00000392429.1	+	2	2688	c.310G>A	c.(310-312)Gtc>Atc	p.V104I	TMEM200A_ENST00000545622.1_Missense_Mutation_p.V104I|TMEM200A_ENST00000296978.3_Missense_Mutation_p.V104I	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	104						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TGAAACTCAGGTCATTCGGAA	0.428000													32	72					0	0	1	0	0
CHST4	10164	broad.mit.edu	37	16	71571390	71571390	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:71571390C>A	ENST00000338482.5	+	3	1153	c.810C>A	c.(808-810)cgC>cgA	p.R270R	CHST4_ENST00000539698.3_Silent_p.R270R|CHST4_ENST00000572450.1_Silent_p.R270R|RP11-510M2.9_ENST00000572693.1_RNA|ZNF19_ENST00000568446.1_Intron			Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	270					cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	21						TGCAGGAACGCTACCTGCTTG	0.547000											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	42					0.014758	0.0148771	1	1	0
ALPPL2	251	broad.mit.edu	37	2	233271616	233271616	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:233271616C>A	ENST00000295453.3	+	1	64	c.12C>A	c.(10-12)ccC>ccA	p.P4P		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	4					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	TGCAGGGGCCCTGGGTGCTGC	0.607000													18	33					1.00905e-13	1.09755e-13	1	1	0
ALG1L2	0	broad.mit.edu	37	3	129817216	129817216	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:129817216C>T	ENST00000507643.1	+	0	798							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										AACTCCTGGGCCAGAGGCTAA	0.592000													8	6					0	0	1	0	0
SV2A	0	broad.mit.edu	37	1	149883426	149883426	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:149883426G>A	ENST00000369146.3	-	3	1219	c.729C>T	c.(727-729)agC>agT	p.S243S	SV2A_ENST00000369145.1_Silent_p.S243S	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	243					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	AGGCGAAGACGCTGTTGACTG	0.567000													10	16					0	0	1	0	0
GNRHR	0	broad.mit.edu	37	4	68619935	68619935	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:68619935G>A	ENST00000226413.4	-	1	143	c.119C>T	c.(118-120)aCg>aTg	p.T40M	RP11-453E17.1_ENST00000500538.2_RNA|RP11-453E17.1_ENST00000502758.1_RNA|GNRHR_ENST00000420975.2_Missense_Mutation_p.T40M	NM_000406.2	NP_000397.1	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor	40					multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	13					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	GAAAGTAACCGTCACTCGGAT	0.453000													4	67					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10469158	10469158	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:10469158G>A	ENST00000382483.3	-	4	2673	c.2450C>T	c.(2449-2451)gCg>gTg	p.A817V		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	817					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GGGGCCCACCGCCCCTTGCTC	0.692000													6	16					0	0	1	0	0
CRYM-AS1	0	broad.mit.edu	37	16	21328282	21328282	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:21328282G>A	ENST00000444326.1	+	0	398																											AAATAAGAACGGACCTTTCGA	0.443000													69	113					0	0	1	0	0
PRSS50	29122	broad.mit.edu	37	3	46753878	46753878	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:46753878G>A	ENST00000460241.1	-	11	2686	c.1016C>T	c.(1015-1017)gCc>gTc	p.A339V	PRSS50_ENST00000315170.7_Missense_Mutation_p.A339V			Q9UI38	TSP50_HUMAN	protease, serine, 50	339	Peptidase S1.				proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11						GATGGGTGGGGCCTCGCTCTT	0.642000													8	12					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222307708	222307708	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:222307708G>A	ENST00000281821.2	-	11	1956	c.1915C>T	c.(1915-1917)Cgt>Tgt	p.R639C	EPHA4_ENST00000409938.1_Missense_Mutation_p.R639C|EPHA4_ENST00000409854.1_Missense_Mutation_p.R639C|EPHA4_ENST00000392071.4_Missense_Mutation_p.R588C	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	639	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		ACTTTGAGACGCCCACTGCAT	0.443000													4	44					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54969700	54969700	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54969700C>T	ENST00000326764.5	+	15	2719	c.2240_splice	c.e15+1	p.T747_splice	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	710							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		ATGATCAAAACGTATGTGGTG	0.617000													16	17					0	0	1	0	0
LSMEM2	132228	broad.mit.edu	37	3	50324108	50324108	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50324108G>A	ENST00000316436.3	+	3	263	c.176G>A	c.(175-177)gGc>gAc	p.G59D		NM_153215.1	NP_694947.1			leucine-rich single-pass membrane protein 2																		CACCCAGCAGGCACACTGCGC	0.637000													6	16					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7060964	7060964	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:7060964A>G	ENST00000299481.4	+	3	655	c.309A>G	c.(307-309)ggA>ggG	p.G103G		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	103					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AGACTATAGGACCAGATGATG	0.468000													17	39					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42041326	42041326	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42041326C>T	ENST00000219905.7	+	17	5702	c.5521C>T	c.(5521-5523)Cgg>Tgg	p.R1841W	MGA_ENST00000566586.1_Missense_Mutation_p.R1632W|MGA_ENST00000570161.1_Missense_Mutation_p.R1841W|MGA_ENST00000389936.4_Missense_Mutation_p.R1802W|MGA_ENST00000545763.1_Missense_Mutation_p.R1632W	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1802						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GATGGGAATCCGGTTACCTGC	0.418000													14	34					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8424212	8424212	+	Silent	SNP	G	G	A	rs146907591		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:8424212G>A	ENST00000337907.3	-	16	2278	c.1644C>T	c.(1642-1644)ccC>ccT	p.P548P	RERE_ENST00000400908.2_Silent_p.P548P|RERE_ENST00000476556.1_5'UTR|RERE_ENST00000400907.2_Intron|RERE_ENST00000377464.1_Silent_p.P280P	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	548					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GCGGGTCCACGGGCTTCTCAA	0.582000													26	25					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158655080	158655080	+	Missense_Mutation	SNP	G	G	A	rs121918642		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158655080G>A	ENST00000368148.3	-	2	262	c.82C>T	c.(82-84)Cgt>Tgt	p.R28C	SPTA1_ENST00000368147.3_Missense_Mutation_p.R28C	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	28			R -> C (in EL2).|R -> H (in EL2; Corbeil; dbSNP:rs28934004).|R -> L (in EL2).|R -> S (in EL2; dbSNP:rs28934005).		actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					ACTTCCTGACGCCTCTCCTGG	0.458000													36	44					0	0	1	0	0
DONSON	29980	broad.mit.edu	37	21	34958331	34958331	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:34958331C>T	ENST00000453626.1	-	3	563	c.559G>A	c.(559-561)Gtc>Atc	p.V187I	DONSON_ENST00000303071.5_Missense_Mutation_p.V187I|DONSON_ENST00000432378.1_Missense_Mutation_p.V187I|AP000304.12_ENST00000429238.1_Missense_Mutation_p.C148Y|DONSON_ENST00000303113.6_Missense_Mutation_p.V187I			Q9NYP3	DONS_HUMAN	downstream neighbor of SON	187					multicellular organismal development	nucleus				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|ovary(1)	11						CAATGCTGGACAAGACCTTGA	0.388000													31	26					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7023302	7023302	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:7023302G>A	ENST00000389658.3	-	19	2655	c.2562C>T	c.(2560-2562)aaC>aaT	p.N854N		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	854	Laminin EGF-like 8.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGGGTCCACGTTGCCGCTGC	0.557000													15	19					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42531860	42531860	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:42531860C>T	ENST00000282030.5	+	4	2851	c.2555C>T	c.(2554-2556)aCg>aTg	p.T852M		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	852						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AAGGAAATCACGCTGTCCCCT	0.562000									Schinzel-Giedion syndrome				12	9					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117232500	117232500	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:117232500C>T	ENST00000003084.6	+	14	2411	c.2279C>T	c.(2278-2280)aCg>aTg	p.T760M	CFTR_ENST00000454343.1_Missense_Mutation_p.T699M	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	760					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ACTGGCCCCACGCTTCAGGCA	0.517000									Cystic Fibrosis				9	8					0	0	1	0	0
TRAV41	0	broad.mit.edu	37	14	22788991	22788991	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22788991G>A	ENST00000390468.1	+	0	204																											TTGTTTCCTTGTTTATGCTGA	0.468000													4	9					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176011468	176011468	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:176011468G>A	ENST00000510636.1	+	19	2460	c.2186G>A	c.(2185-2187)cGc>cAc	p.R729H	CDHR2_ENST00000506348.1_Missense_Mutation_p.R729H|CDHR2_ENST00000261944.5_Missense_Mutation_p.R729H	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	729	Cadherin 7.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GCCAACAACCGCATCAGCTTC	0.657000													7	96					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724806	49724806	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49724806C>T	ENST00000551245.1	+	13	2289	c.2178C>T	c.(2176-2178)acC>acT	p.T726T	TROAP_ENST00000547923.1_Intron|TROAP_ENST00000257909.3_Intron			Q12815	TROAP_HUMAN	trophinin associated protein	743					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						CTGCCCCTACCCCAGGCAATC	0.622000													11	12					0	0	1	0	0
NIPAL3	57185	broad.mit.edu	37	1	24746044	24746044	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:24746044G>A	ENST00000358028.4	+	2	356	c.7G>A	c.(7-9)Gga>Aga	p.G3R	NIPAL3_ENST00000488155.1_3'UTR|NIPAL3_ENST00000374399.4_Missense_Mutation_p.G3R|NIPAL3_ENST00000003912.3_5'UTR|NIPAL3_ENST00000339255.2_Missense_Mutation_p.G3R|NIPAL3_ENST00000428131.1_Missense_Mutation_p.G3R			Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	3						integral to membrane				endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(1)	14						CACCATGGACGGATCCCACAG	0.627000													4	17					0	0	1	0	0
WNT4	54361	broad.mit.edu	37	1	22446662	22446662	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:22446662G>A	ENST00000290167.6	-	5	980	c.937C>T	c.(937-939)Cgc>Tgc	p.R313C	WNT4_ENST00000542383.1_Missense_Mutation_p.R258C	NM_030761.4	NP_110388.2	P56705	WNT4_HUMAN	wingless-type MMTV integration site family, member 4	313					adrenal gland development|androgen biosynthetic process|anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|dermatome development|endoderm development|epithelial to mesenchymal transition|establishment of protein localization in plasma membrane|female gonad development|female sex determination|liver development|male gonad development|mesonephric tubule development|metanephric mesenchymal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of male gonad development|negative regulation of testicular blood vessel morphogenesis|negative regulation of testosterone biosynthetic process|negative regulation of transcription, DNA-dependent|oocyte development|paramesonephric duct development|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of collagen biosynthetic process|positive regulation of cortisol biosynthetic process|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|protein palmitoylation|renal vesicle formation|smooth muscle cell differentiation|somatotropin secreting cell differentiation|tertiary branching involved in mammary gland duct morphogenesis|thyroid-stimulating hormone-secreting cell differentiation|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|extracellular space|Golgi apparatus|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|signal transducer activity|transcription corepressor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	8		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;9.02e-26)|Colorectal(126;1.71e-07)|COAD - Colon adenocarcinoma(152;1.17e-05)|GBM - Glioblastoma multiforme(114;2.01e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000568)|KIRC - Kidney renal clear cell carcinoma(1967;0.00277)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		TGGAAGCCGCGGCCACAGCAC	0.657000													12	12					0	0	1	0	0
GGT7	2686	broad.mit.edu	37	20	33440320	33440320	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:33440320G>A	ENST00000336431.5	-	11	1385	c.1341C>T	c.(1339-1341)ctC>ctT	p.L447L		NM_178026.2	NP_821158.2	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	447					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			NS(2)|breast(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)	20						TATGGCCCCGGAGGTAGGCGG	0.577000													8	46					0	0	1	0	0
NUCB2	4925	broad.mit.edu	37	11	17351800	17351800	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:17351800C>T	ENST00000529010.1	+	12	1348	c.1129C>T	c.(1129-1131)Cgt>Tgt	p.R377C	NUCB2_ENST00000323688.6_Missense_Mutation_p.R377C|NUCB2_ENST00000458064.2_Missense_Mutation_p.R347C	NM_005013.2	NP_005004.1	P80303	NUCB2_HUMAN	nucleobindin 2	377	Binds to necdin (By similarity).					cytosol|ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|plasma membrane	calcium ion binding|DNA binding			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						AGAGCTACAACGTCAGCATGA	0.338000													15	22					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1496891	1496891	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:1496891C>T	ENST00000421627.2	+	2	166	c.32C>T	c.(31-33)cCg>cTg	p.P11L		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	90					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CGGACCCAGCCGCCGCTGTGT	0.706000													11	12					0	0	1	0	0
SEC63	11231	broad.mit.edu	37	6	108243079	108243079	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:108243079C>T	ENST00000369002.4	-	4	553	c.374G>A	c.(373-375)cGt>cAt	p.R125H		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	125	J.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TGACAGCAAACGATATTGTTT	0.348000													19	33					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71135078	71135078	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:71135078C>T	ENST00000333538.5	+	8	2022	c.1388C>T	c.(1387-1389)aCc>aTc	p.T463I	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	463						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TACAATAATACCGTTGCTTAC	0.433000													55	81					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3833723	3833723	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3833723C>T	ENST00000262961.4	-	3	328	c.318G>A	c.(316-318)ccG>ccA	p.P106P	ZFR2_ENST00000591965.1_5'UTR	NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	106						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		ACTGGAAGTACGGCCTGTCCT	0.622000													4	8					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27447963	27447963	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27447963C>T	ENST00000264705.4	+	11	1634	c.1472C>T	c.(1471-1473)gCc>gTc	p.A491V	CAD_ENST00000403525.1_Missense_Mutation_p.A491V	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	491	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CTGACCAAGGCCGGGGTGCTG	0.602000													12	19					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5448495	5448495	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:5448495C>T	ENST00000282908.5	+	7	1080	c.658C>T	c.(658-660)Cgg>Tgg	p.R220W	STK32B_ENST00000508728.1_3'UTR|STK32B_ENST00000512636.1_Missense_Mutation_p.R143W|STK32B_ENST00000510398.1_Missense_Mutation_p.R173W	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	220	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						TGAGCTGCTGCGGGGCTGGGT	0.642000													7	14					0	0	1	0	0
ADORA1	134	broad.mit.edu	37	1	203098231	203098231	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:203098231C>A	ENST00000367236.4	+	2	1183	c.262C>A	c.(262-264)Ctc>Atc	p.L88I	ADORA1_ENST00000367235.1_Missense_Mutation_p.L88I|ADORA1_ENST00000309502.3_Missense_Mutation_p.L88I|ADORA1_ENST00000337894.4_Missense_Mutation_p.L88I	NM_001048230.1	NP_001041695.1	P30542	AA1R_HUMAN	adenosine A1 receptor	88					induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(9)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	CTGTCCGGTCCTCATCCTCAC	0.622000													54	76					1.72039e-30	1.92864e-30	1	1	0
DNAH17	8632	broad.mit.edu	37	17	76488767	76488767	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:76488767G>T	ENST00000389840.5	-	42	6571	c.6447C>A	c.(6445-6447)acC>acA	p.T2149T	RP11-559N14.5_ENST00000585969.1_RNA|DNAH17_ENST00000585328.1_Silent_p.T2158T					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCTCGTCGCAGGTGACGGCCT	0.607000													7	9					0.0293803	0.0295506	1	1	0
PCNXL3	399909	broad.mit.edu	37	11	65392916	65392916	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65392916C>T	ENST00000355703.3	+	18	3609	c.3070C>T	c.(3070-3072)Cgc>Tgc	p.R1024C		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1024						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						GCTGGAGGAGCGCAGCTTGGA	0.711000													15	27					0	0	1	0	0
P4HTM	54681	broad.mit.edu	37	3	49027944	49027944	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49027944C>T	ENST00000343546.4	+	1	623	c.255C>T	c.(253-255)agC>agT	p.S85S	P4HTM_ENST00000383729.4_Silent_p.S85S	NM_177938.2	NP_808807.2	Q9NXG6	P4HTM_HUMAN	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	85						endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21					Vitamin C(DB00126)	TGCACTACAGCAACGGCGACG	0.677000													5	18					0	0	1	0	0
TIGD4	201798	broad.mit.edu	37	4	153691371	153691371	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:153691371G>A	ENST00000304337.2	-	2	1606	c.786C>T	c.(784-786)tcC>tcT	p.S262S		NM_145720.3	NP_663772.1	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	262	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			breast(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.093)					CAAATACATCGGAGGTCATCC	0.408000													30	58					0	0	1	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27797681	27797681	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:27797681C>T	ENST00000396319.2	+	3	282	c.194C>T	c.(193-195)aCg>aTg	p.T65M	TAX1BP1_ENST00000543117.1_Missense_Mutation_p.T65M|TAX1BP1_ENST00000409980.1_Missense_Mutation_p.T65M|TAX1BP1_ENST00000265393.6_Missense_Mutation_p.T65M|TAX1BP1_ENST00000433216.2_5'UTR	NM_006024.6	NP_006015.4	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I) binding protein 1	65					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(8)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31			GBM - Glioblastoma multiforme(3;0.0823)			GATTATTACACGTTTTTATGG	0.378000													20	56					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94344062	94344062	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:94344062C>T	ENST00000282020.4	+	10	1746	c.1488C>T	c.(1486-1488)taC>taT	p.Y496Y	GRID2_ENST00000510992.1_Silent_p.Y401Y	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	496					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATCACAAATACGGAAGCCCAC	0.393000													13	22					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169611766	169611766	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:169611766A>G	ENST00000335742.7	+	7	1559	c.202A>G	c.(202-204)Aca>Gca	p.T68A	PALLD_ENST00000261509.6_Missense_Mutation_p.T450A|PALLD_ENST00000512127.1_Missense_Mutation_p.T68A|PALLD_ENST00000505667.1_Missense_Mutation_p.T450A|PALLD_ENST00000333488.4_Missense_Mutation_p.T327A			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	450					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		ACTGCAAAACACAGCCGTGGC	0.498000									Pancreatic Cancer, Familial Clustering of				44	67					0	0	1	0	0
PARD6B	84612	broad.mit.edu	37	20	49354420	49354420	+	Silent	SNP	G	G	A	rs75953522	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:49354420G>A	ENST00000371610.2	+	2	336	c.93G>A	c.(91-93)tcG>tcA	p.S31S	PARD6B_ENST00000396039.1_Silent_p.S31S	NM_032521.2	NP_115910.1	Q9BYG5	PAR6B_HUMAN	par-6 family cell polarity regulator beta	31	OPR.				axonogenesis|cell cycle|cell division|establishment or maintenance of cell polarity|protein complex assembly|regulation of cell migration|tight junction assembly	cytosol|tight junction	protein binding			NS(1)|breast(1)|endometrium(1)|kidney(4)|lung(3)|urinary_tract(1)	11						GTCGGTTTTCGCTGGAAAGAT	0.338000													17	27					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43622199	43622199	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:43622199C>T	ENST00000340058.5	+	19	3396	c.3216C>T	c.(3214-3216)ttC>ttT	p.F1072F	RET_ENST00000355710.3_Intron	NM_020630.4	NP_065681.1	P07949	RET_HUMAN	ret proto-oncogene	0					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	TTACTAGATTCTAGCACCGCT	0.443000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				6	9					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50912858	50912858	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50912858G>A	ENST00000440232.2	+	17	2142	c.2089G>A	c.(2089-2091)Gcc>Acc	p.A697T	POLD1_ENST00000595904.1_Missense_Mutation_p.A723T|POLD1_ENST00000599857.1_Missense_Mutation_p.A697T	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	697					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		GAAGGTGAGCGCCAACTCCGT	0.687000								DNA polymerases (catalytic subunits)					36	50					0	0	1	0	0
IGKV1-6	0	broad.mit.edu	37	2	89265836	89265836	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:89265836C>T	ENST00000464162.1	-	0	324																											AGGCTGCAGGCTGCTGATGGT	0.488000													64	92					0	0	1	0	0
ARID4B	51742	broad.mit.edu	37	1	235383805	235383805	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:235383805C>T	ENST00000264183.3	-	15	1716	c.1219G>A	c.(1219-1221)Gca>Aca	p.A407T	ARID4B_ENST00000366603.2_Missense_Mutation_p.A407T|ARID4B_ENST00000349213.3_Missense_Mutation_p.A407T	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	407	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TCTGGCAATGCCATCTGAAAT	0.313000													3	27					0	0	1	0	0
RAB32	10981	broad.mit.edu	37	6	146865059	146865059	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:146865059G>A	ENST00000367495.3	+	1	231	c.52G>A	c.(52-54)Gcg>Acg	p.A18T		NM_006834.3	NP_006825.1	Q13637	RAB32_HUMAN	RAB32, member RAS oncogene family	18					protein transport|small GTPase mediated signal transduction	mitochondrion	GTP binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	8		Ovarian(120;0.142)		OV - Ovarian serous cystadenocarcinoma(155;2.68e-09)|GBM - Glioblastoma multiforme(68;0.00608)		cgccgccccagcgcccgAGAC	0.726000													6	13					0	0	1	0	0
AKR1C1	1645	broad.mit.edu	37	10	5008275	5008275	+	Splice_Site	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:5008275T>G	ENST00000380872.4	+	2	444		c.e2+2		AKR1C1_ENST00000477661.1_Splice_Site|AKR1C1_ENST00000434459.2_Splice_Site|AKR1C1_ENST00000380859.1_Splice_Site	NM_001353.5	NP_001344.2			aldo-keto reductase family 1, member C1											breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(2)|ovary(3)|prostate(1)	13						ACTTCAAAGGTACTGTGCCTA	0.428000													27	27					0	0	1	0	0
KDM3A	55818	broad.mit.edu	37	2	86701961	86701961	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:86701961A>G	ENST00000409556.1	+	13	2152	c.1787A>G	c.(1786-1788)gAc>gGc	p.D596G	KDM3A_ENST00000409064.1_Missense_Mutation_p.D596G|KDM3A_ENST00000312912.5_Missense_Mutation_p.D596G|KDM3A_ENST00000542128.1_Missense_Mutation_p.D544G|KDM3A_ENST00000485171.1_3'UTR			Q9Y4C1	KDM3A_HUMAN	lysine (K)-specific demethylase 3A	596					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						AACAAGTATGACAATGAAGCA	0.418000													15	92					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84644455	84644455	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:84644455G>A	ENST00000284136.6	-	14	1666	c.1623C>T	c.(1621-1623)tgC>tgT	p.C541C	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	541	PSI.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						AACAGTCTGCGCAAGCTTTCC	0.478000													26	38					0	0	1	0	0
C3orf18	51161	broad.mit.edu	37	3	50598395	50598395	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50598395C>T	ENST00000357203.3	-	5	900	c.361G>A	c.(361-363)Gcc>Acc	p.A121T	C3orf18_ENST00000486175.1_5'UTR|C3orf18_ENST00000441239.1_Missense_Mutation_p.A101T|C3orf18_ENST00000422619.1_Missense_Mutation_p.A69T|C3orf18_ENST00000449241.1_Missense_Mutation_p.A121T|C3orf18_ENST00000426034.1_Missense_Mutation_p.A121T	NM_016210.4	NP_057294.2	Q9UK00	CC018_HUMAN	chromosome 3 open reading frame 18	121						integral to membrane				lung(1)|pancreas(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.0175)|Kidney(197;0.0207)		ACAGAGGCGGCGTCCCGCCCA	0.632000													24	28					0	0	1	0	0
CTB-52I2.8	0	broad.mit.edu	37	19	18092574	18092574	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18092574C>T	ENST00000601725.1	+	0	190																											CCTGCGAGCGCGTGTTCCTCA	0.662000													11	20					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107849988	107849988	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:107849988C>T	ENST00000328300.6	+	29	2505	c.2261C>T	c.(2260-2262)gCa>gTa	p.A754V	COL4A5_ENST00000361603.2_Missense_Mutation_p.A754V	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	754	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CCAGGATTTGCATTACCTGGG	0.493000									Alport syndrome with Diffuse Leiomyomatosis				38	7					0	0	1	0	0
COG1	9382	broad.mit.edu	37	17	71193077	71193077	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:71193077G>A	ENST00000299886.4	+	3	679	c.599G>A	c.(598-600)tGc>tAc	p.C200Y		NM_018714.2	NP_061184.1	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	200					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18			LUSC - Lung squamous cell carcinoma(166;0.197)			TTGCTCAAATGCCAAGGTGTG	0.488000													10	25					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39578560	39578560	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39578560T>C	ENST00000225550.3	-	4	858	c.859A>G	c.(859-861)Aac>Gac	p.N287D	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	287	Coil 2.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				TCCTGGTGGTTGGTCTCCACC	0.592000													13	76					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975040	20975040	+	Missense_Mutation	SNP	G	G	A	rs148148954		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:20975040G>A	ENST00000261383.3	-	53	10165	c.10166C>T	c.(10165-10167)aCg>aTg	p.T3389M	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3389					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CACCTCCTCCGTAATTTCCTT	0.517000													7	37					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27447925	27447925	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27447925C>T	ENST00000264705.4	+	11	1596	c.1434C>T	c.(1432-1434)ggC>ggT	p.G478G	CAD_ENST00000403525.1_Silent_p.G478G	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	478	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CTTTTGGGGGCCAGACTGCTC	0.582000													14	16					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57598454	57598454	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57598454G>A	ENST00000243077.3	+	72	11582	c.11116G>A	c.(11116-11118)Gac>Aac	p.D3706N		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3706	LDL-receptor class A 30.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TTGCAAGAATGACCGCGTCTG	0.627000													36	36					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50196894	50196894	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:50196894G>A	ENST00000335999.6	-	4	379	c.178C>T	c.(178-180)Cgc>Tgc	p.R60C		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	56								p.R60C(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						TCCAGACAGCGCTCATAAGTC	0.607000													7	41					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17757938	17757938	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:17757938G>T	ENST00000379472.3	+	1	419	c.389G>T	c.(388-390)aGc>aTc	p.S130I	KCNC1_ENST00000265969.6_Missense_Mutation_p.S130I	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	130						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						CTGGACAACAGCGCCGACGAC	0.711000													6	15					0.0215528	0.0217053	1	1	0
CBX8	57332	broad.mit.edu	37	17	77768741	77768741	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:77768741C>T	ENST00000269385.4	-	5	980	c.863G>A	c.(862-864)aGg>aAg	p.R288K		NM_020649.2	NP_065700.1	Q9HC52	CBX8_HUMAN	chromobox homolog 8	288					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)	14			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GAAGGCAGCCCTGTGCTTTAT	0.662000													5	4					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84226744	84226744	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:84226744C>T	ENST00000376499.3	-	13	2258	c.1194G>A	c.(1192-1194)tcG>tcA	p.S398S	TLE1_ENST00000376484.1_Silent_p.S73S|TLE1_ENST00000376472.1_Silent_p.S73S	NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	398	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						TCATCTGGGGCGACATGTTGT	0.687000													6	14					0	0	1	0	0
CTSS	1520	broad.mit.edu	37	1	150730372	150730372	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:150730372G>A	ENST00000368985.3	-	3	471	c.211C>T	c.(211-213)Cac>Tac	p.H71Y	CTSS_ENST00000480760.1_5'UTR|CTSS_ENST00000448301.2_Missense_Mutation_p.H71Y	NM_001199739.1|NM_004079.4	NP_001186668.1|NP_004070.3	P25774	CATS_HUMAN	cathepsin S	71					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	15	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			TCGTATGAGTGCATTCCCATT	0.418000													16	24					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52548294	52548294	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:52548294G>A	ENST00000242839.4	-	2	1218	c.1062C>T	c.(1060-1062)gtC>gtT	p.V354V	ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000418097.2_Silent_p.V354V|ATP7B_ENST00000448424.2_Silent_p.V354V|ATP7B_ENST00000542656.1_Silent_p.V322V|ATP7B_ENST00000344297.5_Silent_p.V354V|ATP7B_ENST00000400370.3_Silent_p.V354V|ATP7B_ENST00000400366.3_Intron	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	354					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ATGTGCCCTGGACCTGGTTTC	0.537000									Wilson disease				8	56					0	0	1	0	0
NABP2	79035	broad.mit.edu	37	12	56619180	56619180	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:56619180G>A	ENST00000380198.2	+	2	601	c.103G>A	c.(103-105)Ggg>Agg	p.G35R	NABP2_ENST00000341463.5_Missense_Mutation_p.G35R|NABP2_ENST00000267023.4_Missense_Mutation_p.G35R					nucleic acid binding protein 2																		GACAAAGGACGGGCATGAGGT	0.502000													30	43					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32127982	32127982	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32127982C>T	ENST00000373672.3	-	58	4150	c.3634G>A	c.(3634-3636)Gcc>Acc	p.A1212T	COL16A1_ENST00000271069.6_Missense_Mutation_p.A1212T	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1212	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TCCAGACCGGCGGGGCCCTGG	0.627000													4	3					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38805233	38805233	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:38805233C>T	ENST00000310301.4	-	16	1330	c.1276G>A	c.(1276-1278)Gca>Aca	p.A426T	VPS41_ENST00000395969.2_Missense_Mutation_p.A401T	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	426					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						CAGAGTGCTGCATTTTTCCCA	0.318000													6	36					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75989260	75989260	+	Missense_Mutation	SNP	C	C	T	rs148122303		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:75989260C>T	ENST00000274364.6	+	31	4283	c.3986C>T	c.(3985-3987)gCg>gTg	p.A1329V	IQGAP2_ENST00000396234.3_Missense_Mutation_p.A825V|IQGAP2_ENST00000502745.1_Missense_Mutation_p.A825V|CTD-2384B11.2_ENST00000507514.1_RNA|IQGAP2_ENST00000379730.3_Missense_Mutation_p.A831V	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1329					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CCAGCAACTGCGCAACAGGTA	0.363000													5	49					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42154447	42154447	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42154447C>T	ENST00000320955.6	-	44	7656	c.7429G>A	c.(7429-7431)Gca>Aca	p.A2477T		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2477					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TGCAGCATTGCCTGGAGTTTC	0.632000													17	33					0	0	1	0	0
CELA2A	63036	broad.mit.edu	37	1	15783259	15783259	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:15783259C>T	ENST00000359621.4	+	1	36	c.11C>T	c.(10-12)aCg>aTg	p.T4M	CELA2A_ENST00000497590.1_3'UTR	NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	4					proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						ATGATAAGGACGCTGCTGCTG	0.542000													20	22					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627062	43627062	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:43627062G>T	ENST00000332857.6	-	4	1653	c.1625C>A	c.(1624-1626)cCt>cAt	p.P542H		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		CCTCAACAAAGGCCATTCAGG	0.483000													6	254					0.000157383	0.000161063	1	1	0
NRP1	8829	broad.mit.edu	37	10	33491899	33491899	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:33491899G>T	ENST00000265371.4	-	12	2309	c.1784C>A	c.(1783-1785)cCc>cAc	p.P595H	NRP1_ENST00000395995.1_Missense_Mutation_p.P595H|NRP1_ENST00000374823.5_Missense_Mutation_p.P595H|NRP1_ENST00000466932.1_Intron|NRP1_ENST00000374821.5_Intron|NRP1_ENST00000374822.4_Missense_Mutation_p.P595H|NRP1_ENST00000374867.2_Missense_Mutation_p.P595H			O14786	NRP1_HUMAN	neuropilin 1	595					axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	GTTCCCGTTGGGAGTGGTCGG	0.498000													26	54					1.77063e-15	1.9385e-15	1	1	0
USH1C	10083	broad.mit.edu	37	11	17531357	17531357	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:17531357G>T	ENST00000005226.7	-	18	1558	c.1559C>A	c.(1558-1560)cCt>cAt	p.P520H	USH1C_ENST00000529563.1_Intron|USH1C_ENST00000527020.1_Intron|USH1C_ENST00000527720.1_Intron|USH1C_ENST00000318024.4_Intron	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	0	PDZ 3.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						AGACACAGAAGGCGGGGGAGG	0.577000													18	31					2.98393e-07	3.1252e-07	1	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121651338	121651338	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:121651338G>A	ENST00000393386.2	+	12	2649	c.2238G>A	c.(2236-2238)tcG>tcA	p.S746S	PTPRZ1_ENST00000483028.1_3'UTR|PTPRZ1_ENST00000449182.1_Silent_p.S746S	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	746					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						TGGTATACTCGCAGACAACCC	0.473000													4	58					0	0	1	0	0
FARP2	9855	broad.mit.edu	37	2	242403384	242403384	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:242403384C>T	ENST00000264042.3	+	17	2052	c.1882C>T	c.(1882-1884)Cgc>Tgc	p.R628C	FARP2_ENST00000545004.1_Missense_Mutation_p.R628C|FARP2_ENST00000373287.4_Missense_Mutation_p.R628C	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	628	DH.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		CAGGAACATGCGCCAGTTAAA	0.502000													5	11					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51289742	51289742	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:51289742G>A	ENST00000261842.5	+	18	2672	c.2566G>A	c.(2566-2568)Gag>Aag	p.E856K	AP4E1_ENST00000560508.1_Missense_Mutation_p.E781K	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	856					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		TTTGGATTCTGAGTCACTCAC	0.358000													38	41					0	0	1	0	0
GDAP2	54834	broad.mit.edu	37	1	118441732	118441732	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:118441732G>T	ENST00000369443.4	-	7	992	c.743C>A	c.(742-744)cCt>cAt	p.P248H	GDAP2_ENST00000369442.3_Missense_Mutation_p.P248H|GDAP2_ENST00000464026.1_5'UTR	NM_017686.3	NP_060156.1	Q9NXN4	GDAP2_HUMAN	ganglioside induced differentiation associated protein 2	248										kidney(2)|large_intestine(3)|lung(9)|ovary(2)	16		all_cancers(81;0.0156)|all_lung(203;5.81e-05)|Lung NSC(69;0.000446)|all_epithelial(167;0.00295)		Lung(183;0.0583)|LUSC - Lung squamous cell carcinoma(189;0.194)		AGGTACCACAGGCTCCCCTTC	0.448000													45	80					8.04919e-23	8.95685e-23	1	1	0
PLAT	5327	broad.mit.edu	37	8	42040326	42040326	+	Silent	SNP	C	C	T	rs146917237	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:42040326C>T	ENST00000220809.4	-	8	970	c.714G>A	c.(712-714)ccG>ccA	p.P238P	PLAT_ENST00000352041.3_Silent_p.P192P|PLAT_ENST00000429710.2_Silent_p.P112P|PLAT_ENST00000429089.2_Silent_p.P238P|PLAT_ENST00000524009.1_Silent_p.P149P|PLAT_ENST00000519510.1_Silent_p.P175P|PLAT_ENST00000270189.6_Silent_p.P238P	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	238	Kringle 2.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TGGAATTCCACGGGAGGCAGG	0.547000													37	54					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803052	185803052	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:185803052G>A	ENST00000302277.6	+	4	3523	c.2929G>A	c.(2929-2931)Gag>Aag	p.E977K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	977						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGAACTGGCTGAGGCCCTTCC	0.398000													38	62					0	0	1	0	0
TMEM168	64418	broad.mit.edu	37	7	112424649	112424649	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:112424649C>T	ENST00000312814.5	-	2	792	c.232G>A	c.(232-234)Gcc>Acc	p.A78T	TMEM168_ENST00000454074.1_Missense_Mutation_p.A78T	NM_022484.4	NP_071929.3	Q9H0V1	TM168_HUMAN	transmembrane protein 168	78						integral to membrane|transport vesicle				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|stomach(1)	32						AGTATGCTGGCGATTCCAAGA	0.343000													23	40					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155721807	155721807	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155721807C>T	ENST00000437809.1	-	30	6536	c.6414G>A	c.(6412-6414)gtG>gtA	p.V2138V	GON4L_ENST00000271883.5_Silent_p.V2138V|GON4L_ENST00000368331.1_Silent_p.V2139V			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	2139					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TGTTGGCACACACCGTAGCTT	0.557000													52	63					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86590931	86590931	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:86590931G>A	ENST00000370571.2	-	3	1454	c.1088C>T	c.(1087-1089)aCc>aTc	p.T363I	COL24A1_ENST00000436319.1_Missense_Mutation_p.T363I	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	363					cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTTCTCTTTGGTATTCATTTT	0.398000													22	38					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331569	85331569	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:85331569C>T	ENST00000440886.1	-	1	273	c.235G>A	c.(235-237)Gct>Act	p.A79T	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Missense_Mutation_p.A79T			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	79					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle		p.A79T(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						GCAATTCCAGCGAAGAAATCG	0.438000													46	71					0	0	1	0	0
DVL2	1856	broad.mit.edu	37	17	7132764	7132764	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7132764C>T	ENST00000005340.5	-	7	1032	c.750G>A	c.(748-750)acG>acA	p.T250T	DVL2_ENST00000574642.1_5'UTR|DVL2_ENST00000575458.1_Silent_p.T244T	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	250					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						TGAAGGATGACGTCTGTGGTG	0.572000													17	43					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	4008056	4008056	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4008056C>T	ENST00000381638.2	-	8	1568	c.1444G>A	c.(1444-1446)Gca>Aca	p.A482T	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	482							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CTTCCTCTTGCGAGAGCAAAA	0.453000													21	24					0	0	1	0	0
MIR197	0	broad.mit.edu	37	1	110141517	110141517	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110141517C>A	ENST00000384976.2	+	0	3					NR_029583.1																						GCTCTGGGGGCTGTGCCGGGT	0.567000													23	51					1.1804e-14	1.28927e-14	1	1	0
PAPD5	64282	broad.mit.edu	37	16	50261831	50261831	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:50261831G>A	ENST00000357464.3	+	12	1600	c.1600G>A	c.(1600-1602)Gta>Ata	p.V534I	PAPD5_ENST00000573002.1_3'UTR|PAPD5_ENST00000436909.3_Missense_Mutation_p.V613I|PAPD5_ENST00000561678.1_Missense_Mutation_p.V503I			Q8NDF8	PAPD5_HUMAN	PAP associated domain containing 5	487					cell division|DNA replication|histone mRNA catabolic process|mitosis	cytoplasm|nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding			endometrium(1)|kidney(1)|lung(2)	4		all_cancers(37;0.0452)		BRCA - Breast invasive adenocarcinoma(181;0.0843)|GBM - Glioblastoma multiforme(240;0.231)		GTCGCAAGATGTATCCTTGGA	0.517000													15	25					0	0	1	0	0
ERGIC2	51290	broad.mit.edu	37	12	29494701	29494701	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:29494701C>T	ENST00000360150.4	-	13	1112	c.1037G>A	c.(1036-1038)cGt>cAt	p.R346H		NM_016570.2	NP_057654.2	Q96RQ1	ERGI2_HUMAN	ERGIC and golgi 2	346					vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane|nucleus				endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)|urinary_tract(1)	10	Lung NSC(12;2.02e-08)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)|Lung SC(9;0.184)				Arsenic trioxide(DB01169)	AAGTCTGAAACGACAGCAAAT	0.303000													52	87					0	0	1	0	0
SBP1	0	broad.mit.edu	37	6	33663472	33663472	+	Translation_Start_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:33663472C>T	ENST00000594414.1	-	1	2	c.3G>A	c.(1-3)atG>atA	p.M1I	ITPR3_ENST00000605930.1_Intron|ITPR3_ENST00000374316.5_Intron																							GGCCTGTTGGCATCTGCTTAA	0.612000													18	37					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43233462	43233462	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:43233462C>T	ENST00000327495.5	-	5	1240	c.1056G>A	c.(1054-1056)ttG>ttA	p.L352L	PSG3_ENST00000595140.1_Silent_p.L352L	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	352	Ig-like C2-type 3.			Missing (in Ref. 9).	defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				CGAAGCAGGACAAGTAGAGGT	0.443000													55	101					0	0	1	0	0
LIAS	11019	broad.mit.edu	37	4	39471653	39471653	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:39471653C>T	ENST00000261434.3	+	8	870	c.752C>T	c.(751-753)cCt>cTt	p.P251L	LIAS_ENST00000381846.1_Missense_Mutation_p.P208L|LIAS_ENST00000340169.2_Missense_Mutation_p.P251L|LIAS_ENST00000513731.1_Missense_Mutation_p.P121L	NM_006859.2	NP_006850.2	O43766	LIAS_HUMAN	lipoic acid synthetase	251					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)|ovary(2)	12					Lipoic Acid(DB00166)	GTTCGTGATCCTCGGGCCAAT	0.423000													5	58					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44869715	44869715	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:44869715C>T	ENST00000372262.3	-	2	837	c.437G>A	c.(436-438)cGc>cAc	p.R146H	CDH22_ENST00000537909.1_Missense_Mutation_p.R146H	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	146	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				CTCCAGTAGGCGGTTGGTGGC	0.627000													15	35					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	5927957	5927957	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:5927957C>A	ENST00000378156.4	-	24	3581		c.e24-1		NPHP4_ENST00000478423.2_Splice_Site	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4						actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GGAACAAGACCTGTGAGGAGG	0.602000													6	21					0.217242	0.217582	1	1	0
CORO7	79585	broad.mit.edu	37	16	4414863	4414863	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:4414863C>T	ENST00000251166.4	-	12	1102	c.957G>A	c.(955-957)gcG>gcA	p.A319A	CORO7_ENST00000574025.1_Silent_p.A234A|CORO7_ENST00000539968.1_Silent_p.A99A|CORO7_ENST00000537233.2_Silent_p.A301A|CORO7-PAM16_ENST00000572467.1_Silent_p.A319A|CORO7_ENST00000423908.2_Silent_p.A151A	NM_024535.4	NP_078811.3			coronin 7											breast(3)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|prostate(2)|skin(2)|urinary_tract(2)	23						TGACGGCCAGCGCCTGCCGGG	0.657000													5	12					0	0	1	0	0
ZBED4	9889	broad.mit.edu	37	22	50278881	50278881	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50278881C>T	ENST00000216268.4	+	2	2048	c.1571C>T	c.(1570-1572)cCg>cTg	p.P524L		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	524						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity	p.P524Q(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GCAAACTCTCCGTATGCCACT	0.502000													20	84					0	0	1	0	0
SCLT1	132320	broad.mit.edu	37	4	129965200	129965200	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:129965200C>T	ENST00000281142.5	-	3	612	c.109G>A	c.(109-111)Gtc>Atc	p.V37I	SCLT1_ENST00000506368.1_Missense_Mutation_p.V37I|SCLT1_ENST00000434680.1_Missense_Mutation_p.V37I|SCLT1_ENST00000439369.2_Missense_Mutation_p.V37I|SCLT1_ENST00000503215.1_Missense_Mutation_p.V14I|SCLT1_ENST00000503401.1_Missense_Mutation_p.V14I|SCLT1_ENST00000511426.1_Missense_Mutation_p.V37I	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	37						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						CCTTGGCAGACAGCTTTCTAT	0.274000													12	23					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107080708	107080708	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:107080708G>A	ENST00000392842.1	+	6	838	c.424G>A	c.(424-426)Gat>Aat	p.D142N	RFX4_ENST00000229387.5_Missense_Mutation_p.D48N|RFX4_ENST00000357881.4_Missense_Mutation_p.D151N|RP11-144F15.1_ENST00000551505.1_Intron	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	142					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						CCAATATTATGATGTGATGTA	0.478000													33	50					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50552182	50552182	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:50552182G>T	ENST00000262794.5	+	6	932	c.849G>T	c.(847-849)aaG>aaT	p.K283N	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Missense_Mutation_p.K283N|MOV10L1_ENST00000545383.1_Missense_Mutation_p.K283N|MOV10L1_ENST00000540615.1_Missense_Mutation_p.K263N	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	283					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GAACCCTAAAGGAAGGAAGAA	0.398000													18	46					1.64113e-05	1.69611e-05	1	1	0
LENG8	114823	broad.mit.edu	37	19	54967330	54967330	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54967330C>T	ENST00000326764.5	+	9	1689	c.1210C>T	c.(1210-1212)Cgc>Tgc	p.R404C	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	367	Ser-rich.						protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GTTTGGCAACCGCAACGTCTT	0.677000													32	48					0	0	1	0	0
PCDHA2	0	broad.mit.edu	37	5	140176990	140176990	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140176990T>C	ENST00000378132.1	+	1	2547	c.2441T>C	c.(2440-2442)tTc>tCc	p.F814S	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_031495.1	NP_113683.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTAAAAAATTCTATATGATT	0.299000													10	19					0	0	1	0	0
TOPORS	10210	broad.mit.edu	37	9	32543368	32543368	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:32543368G>A	ENST00000360538.2	-	3	1271	c.1155C>T	c.(1153-1155)agC>agT	p.S385S	TOPORS_ENST00000379858.1_Silent_p.S320S	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	385					DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		AATCAGAATGGCTGCCTTCTT	0.443000													14	47					0	0	1	0	0
MEX3B	84206	broad.mit.edu	37	15	82336500	82336500	+	Silent	SNP	G	G	A	rs148396945		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:82336500G>A	ENST00000329713.4	-	2	1146	c.711C>T	c.(709-711)gaC>gaT	p.D237D	MEX3B_ENST00000558133.1_3'UTR	NM_032246.3	NP_115622.2	Q6ZN04	MEX3B_HUMAN	mex-3 RNA binding family member B	237					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)	19						AGTCGTTCTCGTCTGTGAGCT	0.632000													14	100					0	0	1	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122280551	122280551	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:122280551G>A	ENST00000398250.1	+	5	741	c.389G>A	c.(388-390)gGt>gAt	p.G130D	PPAPDC1A_ENST00000369073.3_Missense_Mutation_p.G120D|PPAPDC1A_ENST00000439221.1_Intron|PPAPDC1A_ENST00000541332.1_Missense_Mutation_p.G130D|PPAPDC1A_ENST00000398248.1_Intron	NM_001030059.1	NP_001025230.1	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain containing 1A	130					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	20		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		CATTGCACAGGTGACCCCGAT	0.493000													46	73					0	0	1	0	0
SON	6651	broad.mit.edu	37	21	34924855	34924855	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:34924855G>A	ENST00000356577.4	+	3	3793	c.3318G>A	c.(3316-3318)tcG>tcA	p.S1106S	SON_ENST00000381692.2_Intron|SON_ENST00000381679.4_Silent_p.S1106S|SON_ENST00000290239.6_Silent_p.S1106S|SON_ENST00000300278.4_Silent_p.S1106S	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	1106	14 X 6 AA repeats of [ED]-R-S-M-M-S.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						TGATGTCATCGTACTCTGCAG	0.468000													4	54					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101591866	101591866	+	Missense_Mutation	SNP	G	G	A	rs145672804	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:101591866G>A	ENST00000370449.4	+	23	3349	c.3236G>A	c.(3235-3237)cGg>cAg	p.R1079Q		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1079	ABC transmembrane type-1 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCCACAGGCCGGATTGTGAAC	0.443000													23	44					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76200338	76200338	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:76200338G>A	ENST00000298832.9	+	14	1336	c.1131G>A	c.(1129-1131)gcG>gcA	p.A377A	TTLL5_ENST00000557636.1_Silent_p.A377A|TTLL5_ENST00000555422.1_3'UTR	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	377	TTL.				protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		TTAGTGATGCGCCTCTGGACC	0.388000													32	52					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31359373	31359373	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:31359373C>A	ENST00000542188.1	-	5	875	c.562G>T	c.(562-564)Ggg>Tgg	p.G188W	TRPM1_ENST00000256552.6_Missense_Mutation_p.G171W|TRPM1_ENST00000397795.2_Missense_Mutation_p.G149W	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	149					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AAGGCATCCCCTACGTGGCTG	0.498000													4	66					0.150653	0.151081	1	1	0
IQCJ-SCHIP1	0	broad.mit.edu	37	3	158991628	158991628	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:158991628C>T	ENST00000337808.6	+	1	596	c.19C>T	c.(19-21)Cgt>Tgt	p.R7C	IQCJ-SCHIP1_ENST00000485419.1_Intron|IQCJ-SCHIP1_ENST00000412423.2_Missense_Mutation_p.R7C|IQCJ-SCHIP1_ENST00000476809.1_Intron|IQCJ-SCHIP1_ENST00000467442.1_Intron|IQCJ-SCHIP1_ENST00000527095.1_Missense_Mutation_p.R7C	NM_001197107.1|NM_014575.3	NP_001184036.1|NP_055390.1	Q9P0W5	SCHI1_HUMAN		7						cytoplasm	identical protein binding|protein binding	p.R7S(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						GTCCGGGCAGCGTGTTACAAC	0.423000													6	7					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48629119	48629119	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48629119G>A	ENST00000328333.8	-	11	1601	c.1494C>T	c.(1492-1494)acC>acT	p.T498T	COL7A1_ENST00000454817.1_Silent_p.T498T	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	498	Fibronectin type-III 3.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGGAACCACGGTTGCAGGGG	0.647000													20	24					0	0	1	0	0
TONSL	4796	broad.mit.edu	37	8	145661958	145661958	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:145661958G>A	ENST00000409379.3	-	16	2026	c.1997C>T	c.(1996-1998)gCg>gTg	p.A666V	AC084125.4_ENST00000544423.1_RNA	NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	666					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity	p.A507V(1)|p.A666V(1)		biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						CGAGGCAGCCGCCTGGAGCAG	0.667000													15	23					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148903102	148903102	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:148903102C>T	ENST00000264613.6	-	12	2471	c.2209G>A	c.(2209-2211)Gca>Aca	p.A737T	CP_ENST00000462336.1_5'UTR	NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	737	F5/8 type A 3.|Plastocyanin-like 5.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TCCACTGCTGCGATATAGTAT	0.478000													7	133					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115815886	115815886	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:115815886C>T	ENST00000343348.6	-	12	1969	c.1182G>A	c.(1180-1182)acG>acA	p.T394T	CTB-118N6.3_ENST00000514214.1_RNA|SEMA6A_ENST00000257414.8_Silent_p.T394T|CTB-118N6.3_ENST00000508640.1_RNA|CTB-118N6.3_ENST00000510682.1_RNA|SEMA6A_ENST00000510263.1_Silent_p.T394T	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	394	Sema.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity	p.T394T(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TGAGCGGGTGCGTCTTGATGA	0.498000													27	38					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36789870	36789870	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:36789870G>A	ENST00000361475.2	-	2	315	c.142C>T	c.(142-144)Cgc>Tgc	p.R48C	TGM2_ENST00000536724.1_Intron|TGM2_ENST00000536701.1_Missense_Mutation_p.R48C	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	48					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity	p.R48C(1)		endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	TCGTAGTTGCGGCCCTCAAAG	0.637000													12	25					0	0	1	0	0
CLEC9A	283420	broad.mit.edu	37	12	10205327	10205327	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:10205327G>A	ENST00000355819.1	+	4	654	c.41G>A	c.(40-42)aGc>aAc	p.S14N	CLEC9A_ENST00000544751.1_3'UTR	NM_207345.2	NP_997228.1	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	14					positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	22						CAGTGGGATAGCCCAGCACCA	0.423000													22	26					0	0	1	0	0
DMKN	93099	broad.mit.edu	37	19	36001089	36001089	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36001089G>A	ENST00000339686.3	-	6	1160	c.984C>T	c.(982-984)ccC>ccT	p.P328P	DMKN_ENST00000461300.1_5'UTR|DMKN_ENST00000402589.2_Silent_p.P41P|DMKN_ENST00000414866.2_Silent_p.P41P|DMKN_ENST00000488892.1_Silent_p.P41P|DMKN_ENST00000474928.1_5'UTR|DMKN_ENST00000462126.1_5'UTR|DMKN_ENST00000436012.1_Silent_p.P41P|DMKN_ENST00000440396.1_Silent_p.P328P|DMKN_ENST00000429837.1_Silent_p.P267P|DMKN_ENST00000458071.1_Silent_p.P41P|DMKN_ENST00000602781.1_Silent_p.P41P|DMKN_ENST00000451297.2_Silent_p.P328P|DMKN_ENST00000419602.1_Silent_p.P267P|DMKN_ENST00000480502.1_Silent_p.P41P|DMKN_ENST00000424570.2_Silent_p.P328P|DMKN_ENST00000418261.1_Silent_p.P328P|DMKN_ENST00000392206.2_Silent_p.P41P|DMKN_ENST00000472252.2_5'UTR|DMKN_ENST00000467637.1_Silent_p.P41P|DMKN_ENST00000443640.1_Silent_p.P41P|DMKN_ENST00000492341.2_5'UTR|DMKN_ENST00000447113.2_Silent_p.P328P	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	328	Gly-rich.					extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CACTCACCCCGGGTTTATGTC	0.612000											OREG0025431	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	7					0	0	1	0	0
RPLP1	6176	broad.mit.edu	37	15	69747510	69747510	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:69747510C>T	ENST00000260379.6	+	3	314	c.147_splice	c.e3-1	p.A50_splice	RPLP1_ENST00000357790.5_Splice_Site_p.A25_splice|RPLP1_ENST00000560274.1_Intron	NM_001003.2	NP_000994.1	P05386	RLA1_HUMAN	ribosomal protein, large, P1	50					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1						GTATTGCAGGCCCTGGCCAAC	0.562000													24	53					0	0	1	0	0
DCAF13	25879	broad.mit.edu	37	8	104433218	104433218	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:104433218C>T	ENST00000297579.5	+	3	1019	c.742C>T	c.(742-744)Cta>Tta	p.L248L	DCAF13_ENST00000519682.1_Silent_p.L92L|DCAF13_ENST00000521999.1_Intron|DCAF13_ENST00000521971.1_Intron	NM_015420.6	NP_056235.4	Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	96					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						AATTTGGAATCTAACTCAGCG	0.363000													25	46					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	215013934	215013934	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:215013934T>G	ENST00000331683.5	+	15	1759	c.1664T>G	c.(1663-1665)aTt>aGt	p.I555S	SPAG16_ENST00000374309.3_Missense_Mutation_p.I461S	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	555					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTGTTACCAATTGTGTCCATC	0.383000													44	77					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128470942	128470942	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128470942G>A	ENST00000325888.8	+	1	512	c.251G>A	c.(250-252)cGc>cAc	p.R84H	FLNC_ENST00000346177.6_Missense_Mutation_p.R84H	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	84	Actin-binding.|CH 1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CGCATGTACCGCAAGTTCCAT	0.637000													14	13					0	0	1	0	0
SLC4A4	8671	broad.mit.edu	37	4	72352686	72352686	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:72352686A>G	ENST00000340595.3	+	12	1989	c.1793A>G	c.(1792-1794)gAc>gGc	p.D598G	SLC4A4_ENST00000351898.6_Missense_Mutation_p.D642G|SLC4A4_ENST00000264485.5_Missense_Mutation_p.D642G|SLC4A4_ENST00000425175.1_Missense_Mutation_p.D642G	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	642						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			ATATCTAATGACACCACACTG	0.289000													38	86					0	0	1	0	0
DYRK3	8444	broad.mit.edu	37	1	206821277	206821277	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:206821277G>A	ENST00000367106.1	+	4	1147	c.674G>A	c.(673-675)cGc>cAc	p.R225H	DYRK3_ENST00000489878.1_Intron|DYRK3_ENST00000367108.3_Missense_Mutation_p.R225H|DYRK3_ENST00000367109.2_Missense_Mutation_p.R245H			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	245	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			AATGAGAAGCGCTTTCATCGT	0.458000													32	52					0	0	1	0	0
PRSS48	345062	broad.mit.edu	37	4	152203391	152203391	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:152203391G>A	ENST00000455694.2	+	3	309	c.307G>A	c.(307-309)Gtc>Atc	p.V103I	PRSS48_ENST00000441586.2_Intron|SH3D19_ENST00000604030.1_Intron	NM_183375.2	NP_899231.2	Q7RTY5	PRS48_HUMAN	protease, serine, 48	103	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	8						GTCCAAAATCGTCATCCATCC	0.473000													49	83					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489379	237489379	+	Silent	SNP	C	C	T	rs145205829		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:237489379C>T	ENST00000272928.3	+	2	581	c.271C>T	c.(271-273)Ctg>Ttg	p.L91L		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		CATTGCCGACCTGTGGGTTGT	0.572000													20	30					0	0	1	0	0
CCDC173	129881	broad.mit.edu	37	2	170502639	170502639	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:170502639G>A	ENST00000447353.1	-	9	1476	c.1371C>T	c.(1369-1371)tgC>tgT	p.C457C		NM_001085447.1	NP_001078916.1			coiled-coil domain containing 173																		CAGTAAGTCTGCAATAATCTA	0.318000													46	95					0	0	1	0	0
INTS8	55656	broad.mit.edu	37	8	95869126	95869126	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:95869126C>T	ENST00000523731.1	+	15	2007	c.1874C>T	c.(1873-1875)gCt>gTt	p.A625V	INTS8_ENST00000447247.1_Missense_Mutation_p.A625V|INTS8_ENST00000520845.1_3'UTR	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	625					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					ACACACGAAGCTGGGACAGGG	0.483000													42	42					0	0	1	0	0
AP2A2	161	broad.mit.edu	37	11	988650	988650	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:988650C>T	ENST00000448903.2	+	10	1371	c.1230C>T	c.(1228-1230)agC>agT	p.S410S	AP2A2_ENST00000332231.5_Silent_p.S411S|AP2A2_ENST00000534328.1_Intron	NM_001242837.1|NM_012305.3	NP_001229766.1|NP_036437.1	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2 subunit	410					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)	21		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGATGCTGAGCTATCTGGAGA	0.612000													5	63					0	0	1	0	0
HAUS1	115106	broad.mit.edu	37	18	43698194	43698194	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:43698194G>A	ENST00000282058.6	+	3	333	c.253G>A	c.(253-255)Gcc>Acc	p.A85T	HAUS1_ENST00000588704.1_3'UTR|HAUS1_ENST00000585518.1_Intron	NM_138443.3	NP_612452.1	Q96CS2	HAUS1_HUMAN	HAUS augmin-like complex, subunit 1	85					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	7						TTTTTCCCCCGCCAATCTCTC	0.408000													44	59					0	0	1	0	0
RFX2	5990	broad.mit.edu	37	19	6002838	6002838	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6002838G>A	ENST00000303657.5	-	14	1693	c.1544C>T	c.(1543-1545)aCg>aTg	p.T515M	CTC-232P5.1_ENST00000587836.1_RNA|RFX2_ENST00000592546.1_Missense_Mutation_p.T490M|RFX2_ENST00000359161.3_Missense_Mutation_p.T515M	NM_000635.3	NP_000626.2	P48378	RFX2_HUMAN	regulatory factor X, 2 (influences HLA class II expression)	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						GTTGAGGGACGTGTAGCGCCG	0.667000													4	10					0	0	1	0	0
TBX3	6926	broad.mit.edu	37	12	115114268	115114268	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:115114268G>T	ENST00000349155.2	-	5	1852	c.889C>A	c.(889-891)Ctc>Atc	p.L297I	TBX3_ENST00000257566.3_Missense_Mutation_p.L317I	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	317					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		TGCAGGGTGAGCTGTTTTCTG	0.483000													4	56					2.56e-06	2.66106e-06	1	1	0
TMEM187	8269	broad.mit.edu	37	X	153248052	153248052	+	Missense_Mutation	SNP	G	G	A	rs141589321		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153248052G>A	ENST00000369982.4	+	2	1286	c.539G>A	c.(538-540)cGc>cAc	p.R180H		NM_003492.2	NP_003483.1	Q14656	TM187_HUMAN	transmembrane protein 187	180						integral to membrane|transport vesicle				breast(1)|large_intestine(1)|lung(1)|prostate(2)	5	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGGCGCTGCGCACCCACAGG	0.637000													14	2					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230911012	230911012	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:230911012A>G	ENST00000295190.4	-	4	1288	c.830T>C	c.(829-831)aTg>aCg	p.M277T		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	277						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		GAGGGCACACATGTTCTTCCT	0.587000													17	54					0	0	1	0	0
CRTC1	23373	broad.mit.edu	37	19	18879581	18879581	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:18879581C>T	ENST00000338797.6	+	11	1371	c.1346C>T	c.(1345-1347)tCg>tTg	p.S449L	CRTC1_ENST00000601916.1_Intron|CRTC1_ENST00000321949.8_Missense_Mutation_p.S433L|CRTC1_ENST00000594658.1_Missense_Mutation_p.S392L	NM_001098482.1	NP_001091952.1	Q6UUV9	CRTC1_HUMAN	CREB regulated transcription coactivator 1	433					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	19						GGCCAGCCATCGATGGGGATC	0.697000													6	1					0	0	1	0	0
CEBPZ	10153	broad.mit.edu	37	2	37444157	37444157	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:37444157G>A	ENST00000234170.5	-	6	2323	c.2178C>T	c.(2176-2178)tcC>tcT	p.S726S		NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	726					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				AAAGGGCCACGGAGGGATGAA	0.294000													4	58					0	0	1	0	0
ACSBG1	23205	broad.mit.edu	37	15	78487032	78487032	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:78487032A>G	ENST00000258873.4	-	3	474	c.269T>C	c.(268-270)gTg>gCg	p.V90A	ACSBG1_ENST00000560817.1_Intron|ACSBG1_ENST00000558828.1_5'UTR|ACSBG1_ENST00000541759.1_Intron	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	90					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						GCGCAGGCGCACCCGCCCATC	0.642000													6	66					0	0	1	0	0
FOXD4	2298	broad.mit.edu	37	9	118076	118076	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:118076C>T	ENST00000382500.2	-	1	341	c.44G>A	c.(43-45)cGc>cAc	p.R15H		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	15					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CCGGAGGCTGCGCTGCGGTGT	0.642000													32	46					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48121986	48121986	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:48121986C>T	ENST00000311303.3	-	25	3831	c.3486G>A	c.(3484-3486)tcG>tcA	p.S1162S	ABCC12_ENST00000448542.1_3'UTR|ABCC12_ENST00000416054.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	1162	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.S1162S(1)		NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				CCATTCCTAACGATGACTTTC	0.413000													11	23					0	0	1	0	0
MINA	84864	broad.mit.edu	37	3	97677986	97677986	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:97677986C>T	ENST00000333396.6	-	4	1172	c.590G>A	c.(589-591)cGc>cAc	p.R197H	MINA_ENST00000394198.2_Missense_Mutation_p.R197H|MINA_ENST00000360258.4_Missense_Mutation_p.R197H|MINA_ENST00000330299.2_Missense_Mutation_p.R197H	NM_001042533.2|NM_032778.5	NP_001035998.1|NP_116167.3	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen	197	JmjC.				ribosome biogenesis	cytoplasm|nucleolus				breast(2)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)	13						GTGGTAGAGGCGCCAGTGTTT	0.562000													11	14					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140941391	140941391	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140941391G>A	ENST00000277549.5	+	22	3594	c.1025G>A	c.(1024-1026)aGg>aAg	p.R342K	CACNA1B_ENST00000545473.1_Missense_Mutation_p.R176K|CACNA1B_ENST00000371355.4_Missense_Mutation_p.R1151K|CACNA1B_ENST00000371357.1_Missense_Mutation_p.R1151K|CACNA1B_ENST00000371363.1_Missense_Mutation_p.R1150K|CACNA1B_ENST00000371372.1_Missense_Mutation_p.R1150K|CACNA1B_ENST00000277551.2_Missense_Mutation_p.R1150K			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1150					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GTGACCATGAGGTACTTCGAG	0.642000													9	16					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55698949	55698949	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:55698949C>A	ENST00000376350.3	-	14	2520	c.2498G>T	c.(2497-2499)aGc>aTc	p.S833I	PTPRH_ENST00000263434.5_Missense_Mutation_p.S655I	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	833	Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CTGAGACTGGCTGTGGCCCAC	0.587000													16	22					1.45105e-14	1.58388e-14	1	1	0
TRIM58	25893	broad.mit.edu	37	1	248039230	248039230	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:248039230G>A	ENST00000366481.3	+	6	948	c.900G>A	c.(898-900)gcG>gcA	p.A300A	OR2W3_ENST00000537741.1_5'UTR	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	300	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCGCCACGGCGCACCCGAGTC	0.547000													8	15					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136547323	136547323	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:136547323G>A	ENST00000264162.2	-	16	5391	c.5381C>T	c.(5380-5382)gCg>gTg	p.A1794V		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1794	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATTGTCCATCGCACTCCAAAC	0.483000													13	22					0	0	1	0	0
ASB17	127247	broad.mit.edu	37	1	76397784	76397784	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:76397784C>T	ENST00000284142.6	-	1	332	c.193G>A	c.(193-195)Gca>Aca	p.A65T		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	65					intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						GTGAGTAGTGCGTCAAAACCA	0.388000													29	35					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33985438	33985438	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:33985438G>A	ENST00000373381.4	-	69	10886	c.10710C>T	c.(10708-10710)ggC>ggT	p.G3570G		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3426						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGAGCACGAAGCCCGCAATAA	0.627000													5	36					0	0	1	0	0
ATXN2	6311	broad.mit.edu	37	12	111923111	111923111	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:111923111G>A	ENST00000377617.3	-	18	3123	c.2962C>T	c.(2962-2964)Ccc>Tcc	p.P988S	ATXN2_ENST00000389153.4_Missense_Mutation_p.P723S|ATXN2_ENST00000550104.1_Intron|ATXN2_ENST00000542287.2_Missense_Mutation_p.P723S|ATXN2_ENST00000535949.1_Missense_Mutation_p.P699S	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	988	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						ACTGGCATGGGCGTCATAGGT	0.368000													16	140					0	0	1	0	0
TRAPPC12	51112	broad.mit.edu	37	2	3461427	3461427	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:3461427C>T	ENST00000324266.5	+	7	1761	c.1566C>T	c.(1564-1566)gaC>gaT	p.D522D	TRAPPC12_ENST00000469147.1_3'UTR|TRAPPC12_ENST00000382110.2_Silent_p.D522D	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	522							binding										TAGCAGAAGACGGCGGCATGA	0.493000													11	14					0	0	1	0	0
COL26A1	136227	broad.mit.edu	37	7	101063367	101063367	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:101063367G>A	ENST00000313669.7	+	0	460				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		GGGGCCCTGCGCCAACCTCGT	0.652000													20	31					0	0	1	0	0
RPRD1A	55197	broad.mit.edu	37	18	33607203	33607203	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:33607203C>A	ENST00000399022.4	-	5	728	c.557G>T	c.(556-558)aGg>aTg	p.R186M	RPRD1A_ENST00000588737.1_Missense_Mutation_p.R150M|RPRD1A_ENST00000357384.4_Missense_Mutation_p.R186M|RPRD1A_ENST00000319040.6_Missense_Mutation_p.R186M|RPRD1A_ENST00000590898.1_Missense_Mutation_p.R150M|RPRD1A_ENST00000337059.5_Missense_Mutation_p.R150M	NM_018170.3	NP_060640.2	Q96P16	RPR1A_HUMAN	regulation of nuclear pre-mRNA domain containing 1A	186										NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(2)	12						AGAAGCTATCCTCTGATGAAC	0.373000													22	91					3.7963e-18	4.18755e-18	1	1	0
KLF1	10661	broad.mit.edu	37	19	12996949	12996949	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12996949C>T	ENST00000264834.4	-	2	135	c.95G>A	c.(94-96)cGc>cAc	p.R32H		NM_006563.3	NP_006554.1	Q13351	KLF1_HUMAN	Kruppel-like factor 1 (erythroid)	32	Pro-rich.				erythrocyte differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(3)|large_intestine(1)|skin(1)	5		Hepatocellular(1079;0.137)		GBM - Glioblastoma multiforme(1328;0.00016)|Lung(535;0.171)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCTTCGGAGCGCCACCACTG	0.687000													13	12					0	0	1	0	0
MAMDC4	158056	broad.mit.edu	37	9	139751935	139751935	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139751935C>T	ENST00000445819.1	+	20	2510	c.2460C>T	c.(2458-2460)tgC>tgT	p.C820C	MAMDC4_ENST00000317446.2_Silent_p.C741C|MAMDC4_ENST00000485732.1_3'UTR			Q6UXC1	AEGP_HUMAN	MAM domain containing 4	820	MAM 5.				protein transport	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	19	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		ACTCAGACTGCGGCTTCTCCC	0.672000													4	67					0	0	1	0	0
C2orf73	129852	broad.mit.edu	37	2	54570911	54570911	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:54570911G>A	ENST00000398634.2	+	3	331	c.289G>A	c.(289-291)Gac>Aac	p.D97N	C2orf73_ENST00000491538.1_Intron|C2orf73_ENST00000405749.1_Missense_Mutation_p.D39N	NM_001100396.1	NP_001093866.1	Q8N5S3	CB073_HUMAN	chromosome 2 open reading frame 73	97										breast(2)	2						ACCACCTTACGACTCTAAGAG	0.448000													15	27					0	0	1	0	0
IFIT2	3433	broad.mit.edu	37	10	91066443	91066443	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:91066443C>T	ENST00000371826.3	+	2	899	c.730C>T	c.(730-732)Cca>Tca	p.P244S	LIPA_ENST00000371837.1_Intron|LIPA_ENST00000487618.1_Intron	NM_001547.4	NP_001538.4	P09913	IFIT2_HUMAN	interferon-induced protein with tetratricopeptide repeats 2	244					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	12		Colorectal(252;0.0161)				GGAGAAAGCCCCAGGTGTAAC	0.438000													26	41					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97887994	97887994	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:97887994G>A	ENST00000356526.2	+	1	451	c.451G>A	c.(451-453)Gct>Act	p.A151T		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						GTCATATATAGCTGGTATTCT	0.368000													36	97					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69688049	69688049	+	Missense_Mutation	SNP	T	T	C	rs111420468		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:69688049T>C	ENST00000265403.7	+	3	955	c.928T>C	c.(928-930)Tca>Cca	p.S310P	UGT2B10_ENST00000458688.2_Missense_Mutation_p.S226P	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	310					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						TTCTCTGGGGTCAATGGTCAG	0.423000													9	150					0	0	1	0	0
MMP25	64386	broad.mit.edu	37	16	3100101	3100101	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3100101C>T	ENST00000336577.4	+	3	561	c.324C>T	c.(322-324)taC>taT	p.Y108Y	MMP25_ENST00000570755.1_3'UTR	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25	108					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						GTCGCCGGTACGCTCTGAGCG	0.701000													19	38					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21181537	21181537	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:21181537C>T	ENST00000602326.1	-	24	3800	c.3217G>A	c.(3217-3219)Gta>Ata	p.V1073I	EIF4G3_ENST00000537738.1_Missense_Mutation_p.V557I|EIF4G3_ENST00000536266.1_Missense_Mutation_p.V671I|EIF4G3_ENST00000374935.3_Missense_Mutation_p.V787I|EIF4G3_ENST00000400422.1_Missense_Mutation_p.V1067I|EIF4G3_ENST00000374937.3_Missense_Mutation_p.V1073I|EIF4G3_ENST00000264211.8_Missense_Mutation_p.V1067I	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	1067					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GCTTTAGGTACCAGCTGAATT	0.408000													12	71					0	0	1	0	0
CCDC140	151278	broad.mit.edu	37	2	223168793	223168793	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:223168793C>T	ENST00000295226.1	+	2	556	c.172C>T	c.(172-174)Cgc>Tgc	p.R58C		NM_153038.1	NP_694583.1	Q96MF4	CC140_HUMAN	coiled-coil domain containing 140	58										endometrium(4)|large_intestine(1)|prostate(1)	6		Renal(207;0.0376)		Epithelial(121;4.03e-10)|all cancers(144;1.8e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACGGAGTAAACGCAACAGGTG	0.592000													7	9					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67801545	67801545	+	Missense_Mutation	SNP	G	G	A	rs141436710		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:67801545G>A	ENST00000544246.1	-	2	1719	c.1028C>T	c.(1027-1029)aCg>aTg	p.T343M	PCDH9_ENST00000377861.3_Missense_Mutation_p.T343M|PCDH9_ENST00000328454.5_Missense_Mutation_p.T343M|PCDH9_ENST00000456367.1_Missense_Mutation_p.T343M|PCDH9_ENST00000377865.2_Missense_Mutation_p.T343M	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	343	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GATGGTAACCGTTGCTCGAGC	0.463000													39	16					0	0	1	0	0
TXNRD1	7296	broad.mit.edu	37	12	104709674	104709674	+	Splice_Site	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:104709674G>C	ENST00000526691.1	+	5	892	c.436_splice	c.e5+1	p.V146_splice	TXNRD1_ENST00000526950.1_Splice_Site_p.V163_splice|TXNRD1_ENST00000526390.1_Splice_Site_p.V138_splice|TXNRD1_ENST00000525566.1_Splice_Site_p.V244_splice|TXNRD1_ENST00000524698.1_Splice_Site_p.V94_splice|TXNRD1_ENST00000503506.2_Splice_Site_p.V94_splice|TXNRD1_ENST00000427956.1_Splice_Site_p.V209_splice|TXNRD1_ENST00000397736.2_Splice_Site_p.V138_splice|TXNRD1_ENST00000388854.3_Splice_Site_p.V146_splice|TXNRD1_ENST00000378070.4_Splice_Site_p.V193_splice|TXNRD1_ENST00000354940.6_Splice_Site_p.V94_splice|TXNRD1_ENST00000542918.1_Splice_Site_p.V144_splice|TXNRD1_ENST00000540716.1_Splice_Site_p.V56_splice|TXNRD1_ENST00000529546.1_Splice_Site_p.V56_splice|TXNRD1_ENST00000429002.2_Splice_Site_p.V244_splice	NM_001261445.1|NM_003330.3	NP_001248374.1|NP_003321.3	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	244	Glutaredoxin.				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						CGAGGAGACAGGTATGAGAGG	0.433000													12	12					0	0	1	0	0
TIGD3	220359	broad.mit.edu	37	11	65123835	65123835	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65123835C>T	ENST00000309880.5	+	2	763	c.556C>T	c.(556-558)Ccc>Tcc	p.P186S		NM_145719.2	NP_663771.1	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	186	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(3)|large_intestine(1)|lung(9)|prostate(2)|skin(2)	17						TCGGGCAGTGCCCGGCAGCTT	0.602000													74	95					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43047172	43047172	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:43047172G>T	ENST00000428554.2	+	15	2350	c.1207G>T	c.(1207-1209)Gaa>Taa	p.E403*	CCDC30_ENST00000342022.4_Nonsense_Mutation_p.E403*|CCDC30_ENST00000390640.4_Nonsense_Mutation_p.E192*|CCDC30_ENST00000507855.1_Nonsense_Mutation_p.E192*|CCDC30_ENST00000340612.4_Nonsense_Mutation_p.E403*			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	403										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						ATATCAAGAAGAACAACAGAA	0.373000													15	23					2.32078e-09	2.46314e-09	1	1	0
CD2AP	23607	broad.mit.edu	37	6	47563637	47563637	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:47563637A>G	ENST00000359314.5	+	12	1605	c.1149A>G	c.(1147-1149)gcA>gcG	p.A383A		NM_012120.2	NP_036252.1	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	383	Pro-rich.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			CTAAACCAGCAGCTCCACAAG	0.363000													63	98					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21210894	21210894	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:21210894G>A	ENST00000574002.1	-	17	2406	c.1924C>T	c.(1924-1926)Cga>Tga	p.R642*	AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000574091.1_Nonsense_Mutation_p.R633*|ZP2_ENST00000219593.4_Nonsense_Mutation_p.R642*			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	642					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		TTTTTACCTCGCCTGTGCCTA	0.433000													4	10					0	0	1	0	0
RHCG	51458	broad.mit.edu	37	15	90030153	90030153	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:90030153C>T	ENST00000268122.4	-	2	316	c.248G>A	c.(247-249)cGc>cAc	p.R83H	RHCG_ENST00000544600.1_Missense_Mutation_p.R83H	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	83					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					GAAGCCGTAGCGCTGCAGGAA	0.627000													12	13					0	0	1	0	0
CBX4	8535	broad.mit.edu	37	17	77808244	77808244	+	Silent	SNP	G	G	A	rs3833850		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:77808244G>A	ENST00000269397.4	-	5	1374	c.1197C>T	c.(1195-1197)caC>caT	p.H399H		NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	399	His-rich.|Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CGACGGCgtggtggtggtggt	0.711000													3	5					0	0	1	0	0
AP2A1	160	broad.mit.edu	37	19	50285952	50285952	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50285952C>T	ENST00000354293.5	+	4	610	c.444C>T	c.(442-444)gcC>gcT	p.A148A	AP2A1_ENST00000359032.5_Silent_p.A148A|AP2A1_ENST00000600199.1_3'UTR	NM_130787.2	NP_570603.2	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1 subunit	148					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)	19		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		AGGCCTTTGCCGCTGACATCC	0.667000													5	6					0	0	1	0	0
LMBR1	64327	broad.mit.edu	37	7	156549095	156549095	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:156549095C>T	ENST00000353442.4	-	9	985	c.749G>A	c.(748-750)cGa>cAa	p.R250Q	LMBR1_ENST00000359422.4_Missense_Mutation_p.R98Q|LMBR1_ENST00000354505.4_Missense_Mutation_p.R250Q|LMBR1_ENST00000540390.1_Missense_Mutation_p.R229Q	NM_022458.3	NP_071903.2	Q8WVP7	LMBR1_HUMAN	limb development membrane protein 1	250						integral to membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	18	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		ACCATTTAGTCGTCTCTGGAG	0.269000													25	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593390	179593390	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179593390G>A	ENST00000589042.1	-	66	19487	c.19263C>T	c.(19261-19263)gaC>gaT	p.D6421D	TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.D6104D|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Silent_p.D5177D|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6104	Ig-like 45.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGTTTCCCGTCTTTAAGCC	0.403000													11	12					0	0	1	0	0
C10orf54	64115	broad.mit.edu	37	10	73515118	73515118	+	Missense_Mutation	SNP	C	C	T	rs138900194	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:73515118C>T	ENST00000394957.3	-	4	732	c.674G>A	c.(673-675)cGc>cAc	p.R225H	CDH23_ENST00000224721.6_Intron	NM_022153.1	NP_071436.1	Q9H7M9	GI24_HUMAN	chromosome 10 open reading frame 54	225						integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						ATACTCACGGCGGTTGGAGGC	0.642000													3	5					0	0	1	0	0
EEF1G	1937	broad.mit.edu	37	11	62327564	62327564	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62327564G>A	ENST00000378019.3	-	9	1372	c.1282C>T	c.(1282-1284)Cga>Tga	p.R428*	MIR3654_ENST00000496634.2_3'UTR|EEF1G_ENST00000329251.4_Nonsense_Mutation_p.R378*			P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1 gamma	378	EF-1-gamma C-terminal.				response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						TCCTGGCCTCGGAAGACCCAG	0.507000													26	47					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120298824	120298824	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:120298824G>A	ENST00000397843.2	+	8	619	c.453G>A	c.(451-453)tcG>tcA	p.S151S	ARHGEF12_ENST00000532993.1_Silent_p.S48S|ARHGEF12_ENST00000356641.3_Silent_p.S132S	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	151	PDZ.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CACCTGGGTCGCCCCAGATTC	0.517000			T	MLL	AML								9	145					0	0	1	0	0
TTC4	7268	broad.mit.edu	37	1	55207181	55207181	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55207181C>T	ENST00000371281.3	+	10	1246	c.1159C>T	c.(1159-1161)Cga>Tga	p.R387*	TTC4_ENST00000371284.5_3'UTR|MROH7_ENST00000414150.2_3'UTR	NM_004623.4	NP_004614.3	O95801	TTC4_HUMAN	tetratricopeptide repeat domain 4	387							binding			breast(2)|endometrium(3)|kidney(1)|lung(2)|stomach(1)	9						GTACCAGATACGATGACTAAG	0.512000													25	52					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38119905	38119905	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:38119905C>T	ENST00000406386.3	+	7	1597	c.1342C>T	c.(1342-1344)Cga>Tga	p.R448*	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	448					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					TAGAGCTACACGAGACAACCC	0.587000													15	29					0	0	1	0	0
OR51V1	283111	broad.mit.edu	37	11	5221608	5221608	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:5221608G>A	ENST00000321255.1	-	1	322	c.323C>T	c.(322-324)gCc>gTc	p.A108V		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATAGGACTGGGCAATGCAGGA	0.522000													13	14					0	0	1	0	0
RASEF	158158	broad.mit.edu	37	9	85640744	85640744	+	Missense_Mutation	SNP	C	C	T	rs139684719	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:85640744C>T	ENST00000376447.3	-	2	784	c.524G>A	c.(523-525)cGt>cAt	p.R175H		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	175					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TCTGATCTCACGGATGAAGTT	0.403000													43	70					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125521700	125521700	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:125521700G>A	ENST00000431078.1	+	16	2870	c.2506G>A	c.(2506-2508)Gac>Aac	p.D836N		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	836	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGGCATTAAAGACTTCATTCG	0.373000													26	40					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134004684	134004684	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:134004684C>A	ENST00000359428.5	+	4	556	c.412C>A	c.(412-414)Cca>Aca	p.P138T	NUP214_ENST00000451030.1_Missense_Mutation_p.P138T|NUP214_ENST00000411637.2_Missense_Mutation_p.P138T			P35658	NU214_HUMAN	nucleoporin 214kDa	138					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GCAAAAACGCCCATTTGCCTA	0.373000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								8	34					1.12685e-05	1.16601e-05	1	1	0
TUBB1	81027	broad.mit.edu	37	20	57597952	57597952	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:57597952G>A	ENST00000217133.1	+	2	379	c.110G>A	c.(109-111)cGc>cAc	p.R37H		NM_030773.3	NP_110400.1	Q9H4B7	TBB1_HUMAN	tubulin, beta 1 class VI	37					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|skin(2)	16	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	GGGAGCGACCGCGGGGCCTCG	0.597000													9	17					0	0	1	0	0
C11orf24	53838	broad.mit.edu	37	11	68029279	68029279	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:68029279G>A	ENST00000304271.6	-	4	1586	c.1184C>T	c.(1183-1185)gCc>gTc	p.A395V	C11orf24_ENST00000533310.1_Intron	NM_022338.3	NP_071733.1	Q96F05	CK024_HUMAN	chromosome 11 open reading frame 24	395						integral to membrane				endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)	13						GTCTACCACGGCCTGGGTGAG	0.587000													16	26					0	0	1	0	0
FBXO18	84893	broad.mit.edu	37	10	5960417	5960417	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:5960417C>T	ENST00000379999.5	+	14	2333	c.2229C>T	c.(2227-2229)caC>caT	p.H743H	FBXO18_ENST00000362091.4_Silent_p.H692H|FBXO18_ENST00000397269.3_Silent_p.H179H|FBXO18_ENST00000379994.1_Intron	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	692					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						CAGTGCCCCACACCCACGTCT	0.557000													47	50					0	0	1	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401264	11401264	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:11401264C>T	ENST00000002596.5	-	2	1540	c.366G>A	c.(364-366)gcG>gcA	p.A122A		NM_005114.2	NP_005105.1	O14792	HS3S1_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	122						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(3)	15						ACGTGAAATACGCGGGGGTCT	0.612000													24	34					0	0	1	0	0
HIST1H3E	8353	broad.mit.edu	37	6	26225632	26225632	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:26225632C>T	ENST00000360408.1	+	1	250	c.250C>T	c.(250-252)Cgc>Tgc	p.R84C		NM_003532.2	NP_003523.1	P68431	H31_HUMAN	histone cluster 1, H3e	84					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(5)|skin(1)	8		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				GACCGACCTGCGCTTCCAGAG	0.587000													18	35					0	0	1	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179820144	179820144	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:179820144G>A	ENST00000367612.3	-	4	776	c.389C>T	c.(388-390)gCa>gTa	p.A130V		NM_001199260.1|NM_145034.4	NP_001186189.1|NP_659471.1	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	130						endoplasmic reticulum membrane|integral to membrane	protein binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(10)|ovary(1)|skin(2)	18						CCCTAAGTGTGCATCTGCTCT	0.547000													19	32					0	0	1	0	0
ACTR1A	10121	broad.mit.edu	37	10	104242791	104242791	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:104242791G>T	ENST00000369905.4	-	7	790	c.727C>A	c.(727-729)Ctg>Atg	p.L243M	ACTR1A_ENST00000446605.2_Missense_Mutation_p.L196M|ACTR1A_ENST00000545684.1_Missense_Mutation_p.L169M|ACTR1A_ENST00000470322.1_5'UTR|ACTR1A_ENST00000487599.1_Missense_Mutation_p.L243M	NM_005736.3	NP_005727.1	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	243					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	13		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		CCATCAGGCAGGTAGTACTGA	0.532000													41	72					7.77372e-23	8.65221e-23	1	1	0
HRH2	0	broad.mit.edu	37	5	175111083	175111083	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:175111083C>A	ENST00000231683.2	+	1	2620	c.847C>A	c.(847-849)Ctg>Atg	p.L283M	HRH2_ENST00000377291.2_Missense_Mutation_p.L283M	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	283					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity	p.L283M(1)		breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CAACTCAGCCCTGAACCCCAT	0.562000													14	30					8.60227e-14	9.36079e-14	1	1	0
CAPN11	11131	broad.mit.edu	37	6	44148387	44148387	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:44148387A>G	ENST00000398776.1	+	16	1772	c.1734A>G	c.(1732-1734)atA>atG	p.I578M	CAPN11_ENST00000542245.1_Missense_Mutation_p.I578M	NM_007058.3	NP_008989.2	Q9UMQ6	CAN11_HUMAN	calpain 11	578	Domain IV.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	36	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGTTTAAGATAGTGGCAGGAG	0.592000													17	23					0	0	1	0	0
HERC4	26091	broad.mit.edu	37	10	69750903	69750903	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:69750903G>A	ENST00000395198.3	-	12	1572	c.1325C>T	c.(1324-1326)gCt>gTt	p.A442V	HERC4_ENST00000412272.2_Missense_Mutation_p.A442V|HERC4_ENST00000277817.6_Missense_Mutation_p.A332V|HERC4_ENST00000373700.4_Missense_Mutation_p.A442V|HERC4_ENST00000395187.2_3'UTR	NM_022079.2	NP_071362.1	Q5GLZ8	HERC4_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 4	442					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	27						TTACCTAACAGCTAAAAAACT	0.219000													3	48					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43327200	43327200	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:43327200C>T	ENST00000380486.3	-	10	1460	c.1219G>A	c.(1219-1221)Gac>Aac	p.D407N	C2CD2_ENST00000329623.7_Missense_Mutation_p.D252N	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	407						cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						ACCGTGCGGTCCTTTTCTATT	0.562000													17	7					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48683650	48683650	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48683650C>T	ENST00000544264.1	-	23	7631	c.7351G>A	c.(7351-7353)Gtg>Atg	p.V2451M	CELSR3_ENST00000164024.4_Missense_Mutation_p.V2446M			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2446					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AACACAGCCACGCTGACCACC	0.602000													8	13					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170929970	170929970	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:170929970C>T	ENST00000272793.5	+	36	5102	c.5052C>T	c.(5050-5052)tgC>tgT	p.C1684C	UBR3_ENST00000418381.1_Silent_p.C1684C|UBR3_ENST00000392631.1_Silent_p.C505C			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1684					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						TTGCCAGCTGCCTGGGACTTC	0.383000													33	81					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101198116	101198116	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:101198116G>A	ENST00000294728.2	+	7	1769	c.1668G>A	c.(1666-1668)caG>caA	p.Q556Q	VCAM1_ENST00000347652.2_Silent_p.Q464Q|VCAM1_ENST00000370115.1_Silent_p.Q357Q|VCAM1_ENST00000370119.4_Silent_p.Q494Q	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	556	Ig-like C2-type 6.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GGGAGCTACAGCCTCTTTCTG	0.468000													10	43					0	0	1	0	0
ZNF598	90850	broad.mit.edu	37	16	2050146	2050146	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:2050146C>T	ENST00000563630.1	-	9	1481	c.1239G>A	c.(1237-1239)gcG>gcA	p.A413A	ZNF598_ENST00000431526.1_Silent_p.A468A|ZNF598_ENST00000562103.1_Silent_p.A413A			Q86UK7	ZN598_HUMAN	zinc finger protein 598	468						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						CGTACGGCAGCGCCAACCCCA	0.682000													16	25					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71053445	71053445	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:71053445G>A	ENST00000452400.2	-	14	3183	c.3002C>T	c.(3001-3003)aCg>aTg	p.T1001M	NCOA2_ENST00000267974.4_Missense_Mutation_p.T89M	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1001					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			AGACTGAAGCGTCTGTCTTTG	0.502000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								8	7					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160151799	160151799	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:160151799G>A	ENST00000368081.4	+	20	3418	c.2947G>A	c.(2947-2949)Gcc>Acc	p.A983T	ATP1A4_ENST00000418334.1_3'UTR|ATP1A4_ENST00000470705.1_Missense_Mutation_p.A119T	NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	983					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATGGACGTGGCCCTGCGAAT	0.517000													58	65					0	0	1	0	0
AP1M1	8907	broad.mit.edu	37	19	16338437	16338437	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16338437G>A	ENST00000291439.3	+	7	1201	c.752G>A	c.(751-753)cGc>cAc	p.R251H	AP1M1_ENST00000590756.1_Missense_Mutation_p.R179H|AP1M1_ENST00000444449.2_Missense_Mutation_p.R263H|AP1M1_ENST00000541844.1_Missense_Mutation_p.R179H|AP1M1_ENST00000429941.2_Missense_Mutation_p.R251H	NM_032493.3	NP_115882.1	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	251	MHD.				cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|prostate(2)	21						GAGAATGACCGCACCATCTCC	0.612000													56	65					0	0	1	0	0
FOXB1	27023	broad.mit.edu	37	15	60297912	60297912	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:60297912C>T	ENST00000396057.4	+	2	1229	c.750C>T	c.(748-750)caC>caT	p.H250H	FOXB1_ENST00000560857.1_Intron	NM_012182.2	NP_036314.2	Q99853	FOXB1_HUMAN	forkhead box B1	250					axon target recognition|cell migration in diencephalon|epithelial cell differentiation involved in mammary gland alveolus development|floor plate development|hypothalamus cell migration|inferior colliculus development|lactation|mammillothalamic axonal tract development|negative regulation of neuron apoptosis|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|telencephalon cell migration|visual learning	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)	6						CGCTGTGCCACGCGGCGGGCC	0.716000													3	17					0	0	1	0	0
KIAA1958	158405	broad.mit.edu	37	9	115336493	115336493	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:115336493A>G	ENST00000337530.6	+	2	429	c.133A>G	c.(133-135)Aca>Gca	p.T45A	KIAA1958_ENST00000536272.1_Missense_Mutation_p.T45A|KIAA1958_ENST00000374244.3_Missense_Mutation_p.T45A	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	45										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						TGGGAACCTGACAGCAATGTG	0.517000													20	26					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58121794	58121794	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:58121794G>A	ENST00000357272.4	+	28	4925	c.4760G>A	c.(4759-4761)cGc>cAc	p.R1587H	FLNB_ENST00000490882.1_Missense_Mutation_p.R1618H|FLNB_ENST00000295956.4_Missense_Mutation_p.R1587H|FLNB_ENST00000493452.1_Missense_Mutation_p.R1418H|FLNB_ENST00000358537.3_Missense_Mutation_p.R1587H|FLNB_ENST00000429972.2_Missense_Mutation_p.R1587H|FLNB_ENST00000419752.2_Missense_Mutation_p.R1418H|FLNB_ENST00000348383.5_Missense_Mutation_p.R1587H			O75369	FLNB_HUMAN	filamin B, beta	1587					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		AAGACTGGGCGCTATATGATT	0.527000													15	10					0	0	1	0	0
TRBV7-4	0	broad.mit.edu	37	7	142176377	142176377	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:142176377C>T	ENST00000390369.2	-	0	298																											CTGCTCTGTGCACTGGATCTT	0.567000													4	59					0	0	1	0	0
SPACA3	124912	broad.mit.edu	37	17	31323938	31323938	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:31323938G>A	ENST00000580599.1	+	4	623	c.214G>A	c.(214-216)Ggg>Agg	p.G72R	SPACA3_ENST00000269053.3_Missense_Mutation_p.G141R|SPACA3_ENST00000394637.2_3'UTR|SPACA3_ENST00000394638.1_Missense_Mutation_p.G38R			Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	141					cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(9;0.193)			CACCAACAACGGGATCTTCCA	0.592000													23	46					0	0	1	0	0
WNT6	7475	broad.mit.edu	37	2	219736503	219736503	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219736503G>A	ENST00000233948.3	+	3	815	c.598G>A	c.(598-600)Gcg>Acg	p.A200T		NM_006522.3	NP_006513.1	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family, member 6	200					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			large_intestine(1)|ovary(2)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGACATCCGCGCGTTGGTGCA	0.652000													7	11					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104219354	104219354	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:104219354G>A	ENST00000202556.9	-	7	1093	c.811C>T	c.(811-813)Ctg>Ttg	p.L271L		NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	271	Gln-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				TCTTGGTACAGTCTTTTTAAC	0.413000													25	49					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85327309	85327309	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:85327309G>C	ENST00000299927.3	+	1	1425	c.1403G>C	c.(1402-1404)cGg>cCg	p.R468P	ZNF592_ENST00000560079.2_Missense_Mutation_p.R468P			Q92610	ZN592_HUMAN	zinc finger protein 592	468					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCTGGGCCCCGGGTCCCAAAG	0.637000													12	14					0	0	1	0	0
HTR1D	3352	broad.mit.edu	37	1	23520001	23520001	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:23520001G>A	ENST00000374619.1	-	1	1221	c.712C>T	c.(712-714)Cgc>Tgc	p.R238C	HTR1D_ENST00000314113.3_Missense_Mutation_p.R238C	NM_000864.4	NP_000855.1	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	238					G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity			NS(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	GTGGTGAAGCGCTTCCCATAG	0.627000													6	23					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	36976503	36976503	+	Splice_Site	SNP	A	A	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:36976503A>C	ENST00000282516.8	+	9	1993	c.1495_splice	c.e9+1	p.K498_splice	NIPBL_ENST00000448238.2_Splice_Site_p.K498_splice|NIPBL_ENST00000504430.1_3'UTR	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	498					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TTCAAGATAAAGGTAAAATAA	0.318000													15	16					0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90575884	90575884	+	RNA	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:90575884G>T	ENST00000551025.1	+	0	4312							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CAAACGTAGAGTGTCAGCTGA	0.358000													3	20					0.004672	0.00472505	1	1	0
GTF2H4	2968	broad.mit.edu	37	6	30879819	30879819	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30879819G>A	ENST00000259895.4	+	10	1077	c.854G>A	c.(853-855)cGc>cAc	p.R285H	GTF2H4_ENST00000376316.2_Missense_Mutation_p.R285H|GTF2H4_ENST00000539324.1_3'UTR	NM_001517.4	NP_001508.1	Q92759	TF2H4_HUMAN	general transcription factor IIH, polypeptide 4, 52kDa	285					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(3)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11						TACCCCACACGCCTGGCCATC	0.498000								Nucleotide excision repair (NER)					17	51					0	0	1	0	0
SPECC1L	23384	broad.mit.edu	37	22	24718719	24718719	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:24718719G>A	ENST00000314328.9	+	5	2056	c.1771G>A	c.(1771-1773)Gca>Aca	p.A591T	KB-1896H10.1_ENST00000358654.2_Missense_Mutation_p.A591T|SPECC1L_ENST00000541492.1_Missense_Mutation_p.A591T|SPECC1L_ENST00000416735.1_Intron|SPECC1L_ENST00000437398.1_Missense_Mutation_p.A591T	NM_001254733.1|NM_015330.3	NP_001241662.1|NP_056145.3	Q69YQ0	CYTSA_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1-like	591					cell cycle|cell division					breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(3)|stomach(2)|urinary_tract(1)	27						GCAGAAAGTGGCAGAGCTGTA	0.478000													25	40					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48461154	48461154	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48461154G>A	ENST00000358536.4	-	11	2810	c.2541C>T	c.(2539-2541)ggC>ggT	p.G847G	PLXNB1_ENST00000358459.4_Intron|PLXNB1_ENST00000296440.6_Silent_p.G847G|PLXNB1_ENST00000448774.2_Intron|PLXNB1_ENST00000456774.1_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	847					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGGGCAGCTCGCCGCCTTCTC	0.682000													4	11					0	0	1	0	0
SPATS2L	26010	broad.mit.edu	37	2	201305436	201305436	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:201305436C>T	ENST00000409988.3	+	8	1240	c.717C>T	c.(715-717)cgC>cgT	p.R239R	SPATS2L_ENST00000451764.2_Silent_p.R239R|SPATS2L_ENST00000409151.1_Silent_p.R247R|SPATS2L_ENST00000360760.5_Silent_p.R170R|SPATS2L_ENST00000358677.4_Silent_p.R239R|SPATS2L_ENST00000409140.3_Silent_p.R239R|SPATS2L_ENST00000409385.1_Silent_p.R179R|SPATS2L_ENST00000409755.3_Silent_p.R269R|SPATS2L_ENST00000409718.1_Silent_p.R239R	NM_001100422.1	NP_001093892.1	Q9NUQ6	SPS2L_HUMAN	spermatogenesis associated, serine-rich 2-like	239						cytoplasm|nucleolus				endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	10						CTAGATATCGCGTCATGATTA	0.378000													14	18					0	0	1	0	0
PDE8A	5151	broad.mit.edu	37	15	85681108	85681108	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:85681108C>T	ENST00000310298.4	+	23	2716	c.2464C>T	c.(2464-2466)Cgg>Tgg	p.R822W	PDE8A_ENST00000339708.5_Missense_Mutation_p.R776W|PDE8A_ENST00000557957.1_Missense_Mutation_p.R750W|PDE8A_ENST00000394553.1_Missense_Mutation_p.R822W			O60658	PDE8A_HUMAN	phosphodiesterase 8A	822					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	25	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			AATGAAGCTGCGGAACCTCCG	0.493000													13	18					0	0	1	0	0
ZNF782	158431	broad.mit.edu	37	9	99581281	99581281	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:99581281G>A	ENST00000481138.1	-	6	1685	c.1024C>T	c.(1024-1026)Cca>Tca	p.P342S	ZNF782_ENST00000535338.1_Missense_Mutation_p.P210S	NM_001001662.1	NP_001001662.1	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(8)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)	33		Acute lymphoblastic leukemia(62;0.0527)				TCTGTACATGGGTGATAATCA	0.408000													53	96					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150767909	150767909	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:150767909C>T	ENST00000485713.1	+	12	2700	c.1660C>T	c.(1660-1662)Cgt>Tgt	p.R554C	SLC4A2_ENST00000461735.1_Missense_Mutation_p.R540C|SLC4A2_ENST00000310317.5_Missense_Mutation_p.R472C|SLC4A2_ENST00000413384.2_Missense_Mutation_p.R554C|SLC4A2_ENST00000392826.2_Missense_Mutation_p.R545C	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	554					bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGTGCCTGTGCGTTTCCTCTT	0.632000													18	21					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238256467	238256467	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:238256467C>A	ENST00000295550.4	-	31	7464	c.7012G>T	c.(7012-7014)Ggc>Tgc	p.G2338C	COL6A3_ENST00000472056.1_Missense_Mutation_p.G1731C|COL6A3_ENST00000353578.4_Missense_Mutation_p.G2132C|COL6A3_ENST00000346358.4_Missense_Mutation_p.G2138C|COL6A3_ENST00000409809.1_Missense_Mutation_p.G2132C|COL6A3_ENST00000347401.3_Missense_Mutation_p.G2137C	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2338	Collagen-like 5.|Triple-helical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCTCTGATGCCTTTGGGTCCT	0.498000													3	16					0.150653	0.151081	1	1	0
NUP210	23225	broad.mit.edu	37	3	13377070	13377070	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:13377070C>T	ENST00000254508.5	-	28	3809	c.3727G>A	c.(3727-3729)Gtg>Atg	p.V1243M		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1243					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CGGCCGAGCACGTTCATGGCA	0.602000													3	23					0	0	1	0	0
PRR11	55771	broad.mit.edu	37	17	57247185	57247185	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:57247185C>A	ENST00000262293.4	+	2	384	c.72C>A	c.(70-72)gcC>gcA	p.A24A		NM_018304.3	NP_060774.2	Q96HE9	PRR11_HUMAN	proline rich 11	24										breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|pancreas(1)	16	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					AAAAAGAAGCCTCTCACTTTC	0.378000													36	60					2.1956e-27	2.45572e-27	1	1	0
SLC4A3	6508	broad.mit.edu	37	2	220500496	220500496	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:220500496C>T	ENST00000358055.3	+	14	2586	c.2074C>T	c.(2074-2076)Cgg>Tgg	p.R692W	SLC4A3_ENST00000373760.2_Missense_Mutation_p.R692W|SLC4A3_ENST00000373762.3_Missense_Mutation_p.R719W|SLC4A3_ENST00000273063.6_Missense_Mutation_p.R719W|SLC4A3_ENST00000317151.3_Missense_Mutation_p.R692W			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	692					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGTGAGGCGCCGGTACCCGCA	0.627000													5	7					0	0	1	0	0
ACTBL2	345651	broad.mit.edu	37	5	56777946	56777946	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:56777946G>A	ENST00000423391.1	-	1	690	c.589C>T	c.(589-591)Cga>Tga	p.R197*	CTD-2023N9.1_ENST00000506106.1_RNA	NM_001017992.3	NP_001017992.1	Q562R1	ACTBL_HUMAN	actin, beta-like 2	197						cytoplasm|cytoskeleton	ATP binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(3)|pancreas(1)|prostate(2)	28		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		TTATAGCCTCGCTCTGTCAGG	0.532000													28	27					0	0	1	0	0
DHRS4L2	317749	broad.mit.edu	37	14	24470245	24470245	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:24470245C>T	ENST00000335125.6	+	5	609	c.483C>T	c.(481-483)ggC>ggT	p.G161G	DHRS4L2_ENST00000558753.1_Intron|DHRS4L2_ENST00000545240.1_Intron|DHRS4L2_ENST00000543805.1_Intron|DHRS4L2_ENST00000537912.1_Intron|DHRS4L2_ENST00000534993.1_Intron|DHRS4L2_ENST00000382755.4_Silent_p.G159G|DHRS4L2_ENST00000397071.1_Intron	NM_198083.3	NP_932349.2	D5KJA1	D5KJA1_HUMAN	dehydrogenase/reductase (SDR family) member 4 like 2	99							binding|oxidoreductase activity			breast(1)|endometrium(2)|kidney(1)|lung(2)|ovary(1)|skin(2)|stomach(1)	10				GBM - Glioblastoma multiforme(265;0.00962)		TTTCCAGAGGCGGCTCAGTGG	0.552000													21	66					0	0	1	0	0
TNFSF14	0	broad.mit.edu	37	19	6664968	6664968	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:6664968G>A	ENST00000326176.9	-	5	965	c.584C>T	c.(583-585)aCc>aTc	p.T195I	TNFSF14_ENST00000245912.3_Missense_Mutation_p.T195I|TNFSF14_ENST00000599359.1_Missense_Mutation_p.T231I	NM_003807.3|NM_172014.2	NP_003798.2|NP_742011.2	O43557	TNF14_HUMAN	tumor necrosis factor (ligand) superfamily, member 14	231					cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18						GTAAGACCGGGTACCATCACG	0.592000													35	43					0	0	1	0	0
FICD	11153	broad.mit.edu	37	12	108912734	108912734	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:108912734A>G	ENST00000552695.1	+	3	1094	c.859A>G	c.(859-861)Atc>Gtc	p.I287V	FICD_ENST00000361549.2_3'UTR	NM_007076.2	NP_009007.2	Q9BVA6	FICD_HUMAN	FIC domain containing	287	Fido.				negative regulation of Rho GTPase activity	integral to membrane	binding|protein adenylyltransferase activity			NS(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(1)|prostate(1)|upper_aerodigestive_tract(2)	15						CTCCGTCACCATCAGCGACGT	0.612000													6	18					0	0	1	0	0
MAMDC2	256691	broad.mit.edu	37	9	72723166	72723166	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:72723166G>A	ENST00000377182.4	+	3	805	c.188G>A	c.(187-189)gGg>gAg	p.G63E	MAMDC2-AS1_ENST00000414515.3_RNA|MAMDC2-AS1_ENST00000591368.1_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	63	MAM 1.					endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						GGCAAGCAGGGGGAGAAAGCT	0.458000													29	43					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50151655	50151655	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:50151655C>T	ENST00000347869.3	+	20	1985	c.1810C>T	c.(1810-1812)Cga>Tga	p.R604*		NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	604	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGAATTGGTGCGAAATGGAGA	0.468000													20	27					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133209374	133209374	+	Silent	SNP	G	G	A	rs147806951		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:133209374G>A	ENST00000320574.5	-	44	6055	c.6012C>T	c.(6010-6012)atC>atT	p.I2004I	POLE_ENST00000535270.1_Silent_p.I1977I	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	2004					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		ACACGGCCACGATGTACGCTG	0.652000								DNA polymerases (catalytic subunits)					16	19					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178937024	178937024	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:178937024C>A	ENST00000263967.3	+	11	1862	c.1705C>A	c.(1705-1707)Ctt>Att	p.L569I		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	569	PI3K helical.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACCCAAATTGCTTCTGTCTGT	0.343000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			24	45					2.79863e-10	2.98826e-10	1	1	0
WT1	7490	broad.mit.edu	37	11	32417839	32417839	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:32417839G>A	ENST00000332351.3	-	7	1497	c.1213C>T	c.(1213-1215)Ctg>Ttg	p.L405L	WT1_ENST00000448076.3_Silent_p.L405L|WT1_ENST00000379079.2_Silent_p.L193L|WT1_ENST00000530998.1_Silent_p.L176L	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1	337			H -> R (in DDS).		adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.L337fs*5(1)	EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			AAGTGGGACAGCTTAAAATAT	0.527000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				21	32					0	0	1	0	0
NUP107	57122	broad.mit.edu	37	12	69107518	69107518	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:69107518C>A	ENST00000229179.4	+	11	1231	c.899C>A	c.(898-900)aCt>aAt	p.T300N	NUP107_ENST00000539906.1_Missense_Mutation_p.T271N|NUP107_ENST00000378905.2_Missense_Mutation_p.T149N	NM_020401.2	NP_065134.1	P57740	NU107_HUMAN	nucleoporin 107kDa	300					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			AGGGAAAATACTCTGCATACC	0.328000													23	51					3.28513e-13	3.56457e-13	1	1	0
HYDIN	54768	broad.mit.edu	37	16	70867855	70867855	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:70867855G>A	ENST00000393567.2	-	79	13764	c.13614C>T	c.(13612-13614)ccC>ccT	p.P4538P		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	4538										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GATACACCACGGGTCCAAAGG	0.597000													4	10					0	0	1	0	0
CKAP5	9793	broad.mit.edu	37	11	46818416	46818416	+	Silent	SNP	G	G	A	rs138784594	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46818416G>A	ENST00000529230.1	-	12	1459	c.1413C>T	c.(1411-1413)ggC>ggT	p.G471G	CKAP5_ENST00000312055.5_Silent_p.G471G|CKAP5_ENST00000354558.3_Silent_p.G471G|CKAP5_ENST00000415402.1_Silent_p.G471G			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	471					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						CTGCTTTCTCGCCAACCACCT	0.428000													43	56					0	0	1	0	0
MON1A	84315	broad.mit.edu	37	3	49948222	49948222	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49948222G>T	ENST00000417270.1	-	5	1426	c.733C>A	c.(733-735)Ctc>Atc	p.L245I	MON1A_ENST00000455683.2_Missense_Mutation_p.L172I|CTD-2330K9.3_ENST00000419183.1_Intron|MON1A_ENST00000296473.3_Missense_Mutation_p.L334I			Q86VX9	MON1A_HUMAN	MON1 secretory trafficking family member A	237							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TAGATGTAGAGCAGCTCCTGC	0.592000													3	30					6.4e-05	6.5734e-05	1	1	0
LGSN	51557	broad.mit.edu	37	6	64029819	64029819	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:64029819C>A	ENST00000370658.5	-	1	63	c.30_splice	c.e1+1	p.E10_splice	LGSN_ENST00000370657.4_Splice_Site_p.E10_splice	NM_001143940.1|NM_016571.2	NP_001137412.1|NP_057655.2	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	10					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	AGCTTCATACCTCCTGCAGAA	0.303000													12	19					1.08611e-07	1.14056e-07	1	1	0
ZNF74	7625	broad.mit.edu	37	22	20759925	20759925	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:20759925G>A	ENST00000400451.2	+	5	1116	c.602G>A	c.(601-603)cGc>cAc	p.R201H	ZNF74_ENST00000357502.5_Silent_p.T206T|ZNF74_ENST00000356671.5_Missense_Mutation_p.R201H|ZNF74_ENST00000403682.3_Silent_p.T172T|ZNF74_ENST00000405993.1_Missense_Mutation_p.R169H	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	201					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CTGGACACACGCAAGAACGTC	0.637000													6	6					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	9017192	9017192	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:9017192G>T	ENST00000344836.4	-	3	461	c.263C>A	c.(262-264)cCt>cAt	p.P88H	USP7_ENST00000381886.4_Missense_Mutation_p.P72H|USP7_ENST00000566224.1_5'UTR|USP7_ENST00000535863.1_5'UTR	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	88	Interaction with TSPYL5.|Interaction with p53/TP53, MDM2 and EBNA1.|MATH.|Necessary for nuclear localization.				interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						AAAACACGGAGGGCTAAGGAC	0.493000													17	39					3.41278e-10	3.64137e-10	1	1	0
PTPRD	5789	broad.mit.edu	37	9	8404589	8404589	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:8404589G>A	ENST00000381196.4	-	33	4701	c.4158C>T	c.(4156-4158)taC>taT	p.Y1386Y	PTPRD_ENST00000356435.5_Silent_p.Y1386Y|PTPRD_ENST00000537002.1_Silent_p.Y976Y|PTPRD_ENST00000540109.1_Silent_p.Y1386Y|PTPRD_ENST00000355233.5_Silent_p.Y980Y|PTPRD_ENST00000486161.1_Silent_p.Y979Y|PTPRD_ENST00000360074.4_Silent_p.Y1373Y|PTPRD_ENST00000358503.5_Silent_p.Y1364Y|PTPRD_ENST00000397606.3_Silent_p.Y979Y|PTPRD_ENST00000397611.3_Silent_p.Y976Y|PTPRD_ENST00000397617.3_Silent_p.Y979Y	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1386	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTACATTCGCGTATCTATTCT	0.383000										TSP Lung(15;0.13)			27	36					0	0	1	0	0
LACE1	246269	broad.mit.edu	37	6	108798484	108798484	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:108798484C>T	ENST00000368977.4	+	10	1237	c.1051C>T	c.(1051-1053)Ctg>Ttg	p.L351L		NM_145315.3	NP_660358.2	Q8WV93	LACE1_HUMAN	lactation elevated 1	351							ATP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		ATTTGAAGAGCTGTGTGAGAG	0.448000													14	27					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56356548	56356548	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56356548G>A	ENST00000340482.3	-	5	978	c.802C>T	c.(802-804)Cgc>Tgc	p.R268C	MPO_ENST00000225275.3_Missense_Mutation_p.R236C			P05164	PERM_HUMAN	myeloperoxidase	236					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	GTGGGGAAGCGCACGATCTCG	0.687000													10	9					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192711277	192711277	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:192711277C>T	ENST00000304141.4	-	1	704	c.375G>A	c.(373-375)acG>acA	p.T125T	AC098617.1_ENST00000424116.2_RNA	NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	125						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TGACCGCGCGCGTGTGGGCGC	0.602000													25	30					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59544078	59544078	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:59544078C>T	ENST00000038176.3	-	6	573	c.361G>A	c.(361-363)Gtt>Att	p.V121I	NSMAF_ENST00000427130.2_Missense_Mutation_p.V152I	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	121					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				TATGGTGCAACAACATTATGT	0.259000													7	13					0	0	1	0	0
DBH	1621	broad.mit.edu	37	9	136501721	136501721	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136501721C>T	ENST00000393056.2	+	1	240	c.228C>T	c.(226-228)ctC>ctT	p.L76L		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	76	DOMON.				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding	p.L76L(1)		central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	ATTTCCAGCTCCTGGTGCGGA	0.627000													16	14					0	0	1	0	0
CACNG8	59283	broad.mit.edu	37	19	54483212	54483212	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54483212G>A	ENST00000270458.2	+	3	562	c.459G>A	c.(457-459)aaG>aaA	p.K153K		NM_031895.5	NP_114101.4	Q8WXS5	CCG8_HUMAN	calcium channel, voltage-dependent, gamma subunit 8	153					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			kidney(1)|large_intestine(3)|lung(8)|urinary_tract(1)	13	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		GCGTCTACAAGTCCAAGAGGA	0.687000													4	6					0	0	1	0	0
FHL5	9457	broad.mit.edu	37	6	97051568	97051568	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:97051568C>T	ENST00000326771.2	+	3	459	c.79C>T	c.(79-81)Cca>Tca	p.P27S	FHL5_ENST00000541107.1_Missense_Mutation_p.P27S	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5	27						nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		GGATGACAGTCCATACTGTGT	0.353000													38	54					0	0	1	0	0
CDS2	8760	broad.mit.edu	37	20	5169772	5169772	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:5169772G>A	ENST00000460006.1	+	11	1348	c.1041G>A	c.(1039-1041)tcG>tcA	p.S347S	CDS2_ENST00000379070.3_3'UTR|CDS2_ENST00000379062.4_Silent_p.S227S|CDS2_ENST00000535100.1_Silent_p.S117S	NM_003818.3	NP_003809.1	O95674	CDS2_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2	347					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|stomach(1)	14						CCTTTGCCTCGCTCATTGGCC	0.463000													11	64					0	0	1	0	0
MMRN2	79812	broad.mit.edu	37	10	88702705	88702705	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:88702705C>T	ENST00000372027.4	-	6	1909	c.1836G>A	c.(1834-1836)gcG>gcA	p.A612A		NM_024756.2	NP_079032.2	Q9H8L6	MMRN2_HUMAN	multimerin 2	612						extracellular space				breast(1)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|stomach(1)	19						CCCCGAAGAGCGCGGCCAGCA	0.741000													4	3					0	0	1	0	0
RSG1	79363	broad.mit.edu	37	1	16559499	16559499	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:16559499G>A	ENST00000375599.3	-	3	698	c.279C>T	c.(277-279)acC>acT	p.T93T		NM_030907.3	NP_112169.2	Q9BU20	RSG1_HUMAN	REM2 and RAB-like small GTPase 1	93	Small GTPase-like.				cellular protein localization|cilium assembly|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|small GTPase mediated signal transduction	cilium|microtubule basal body	GTP binding			large_intestine(2)|lung(2)|pancreas(1)|prostate(1)	6						AAAATACCACGGTGGTCTGGA	0.552000													22	39					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156498308	156498308	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156498308C>T	ENST00000361170.2	-	36	4676	c.4666G>A	c.(4666-4668)Gcc>Acc	p.A1556T		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1556					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity	p.A1556T(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TACTGAGAGGCGGGAAGATCT	0.547000													18	32					0	0	1	0	0
CLNK	116449	broad.mit.edu	37	4	10515166	10515166	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:10515166G>A	ENST00000226951.6	-	16	1067	c.828C>T	c.(826-828)agC>agT	p.S276S	CLNK_ENST00000515667.1_Silent_p.S14S	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	276					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						GAGGGCTGCAGCTGGCTGGAG	0.478000													6	5					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	60003749	60003749	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:60003749G>A	ENST00000444766.3	-	2	356	c.281C>T	c.(280-282)gCt>gTt	p.A94V	INTS2_ENST00000251334.6_Missense_Mutation_p.A86V	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	94					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						TTGTTCTAAAGCATGAAAGTC	0.403000													19	28					0	0	1	0	0
C15orf27	123591	broad.mit.edu	37	15	76430183	76430183	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:76430183C>A	ENST00000388942.3	+	3	450	c.174C>A	c.(172-174)tcC>tcA	p.S58S		NM_152335.2	NP_689548.2	Q2M3C6	CO027_HUMAN	chromosome 15 open reading frame 27	58						integral to membrane				endometrium(1)|large_intestine(1)|lung(10)|pancreas(1)	13						TCGATCTCTCCACGGCGGGCT	0.542000													17	34					1.33834e-09	1.42249e-09	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105420184	105420184	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:105420184G>A	ENST00000333244.5	-	7	1723	c.1604C>T	c.(1603-1605)gCc>gTc	p.A535V	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	535						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CATCCACCCGGCTCCTTCCAC	0.577000													47	54					0	0	1	0	0
AGR2	10551	broad.mit.edu	37	7	16839397	16839397	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:16839397C>T	ENST00000419304.2	-	5	453	c.301G>A	c.(301-303)Gca>Aca	p.A101T	AGR2_ENST00000419572.2_Missense_Mutation_p.A121T|AGR2_ENST00000401412.1_Missense_Mutation_p.A101T	NM_006408.3	NP_006399.1	O95994	AGR2_HUMAN	anterior gradient 2	101					mucus secretion	endoplasmic reticulum|extracellular region	protein binding			endometrium(2)|lung(1)|prostate(1)|skin(2)	6	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		AACTGCTCTGCCAATTTCTGG	0.318000													15	35					0	0	1	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28285226	28285226	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:28285226T>C	ENST00000373894.3	+	8	1436	c.1245T>C	c.(1243-1245)tgT>tgC	p.C415C	SMPDL3B_ENST00000549094.1_Silent_p.C367C|RP11-460I13.2_ENST00000448015.1_RNA	NM_014474.2	NP_055289.2	Q92485	ASM3B_HUMAN	sphingomyelin phosphodiesterase, acid-like 3B	415					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	16		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		AGCACGTGTGTGCCATGCGCC	0.627000													30	41					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12985242	12985242	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12985242G>A	ENST00000251472.4	+	26	4310	c.4271G>A	c.(4270-4272)aGc>aAc	p.S1424N		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	1424					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						GGCCGGCGCAGCAGCTCTGGC	0.706000													19	21					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41424022	41424022	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:41424022G>A	ENST00000400454.1	-	30	5525	c.5048C>T	c.(5047-5049)aCg>aTg	p.T1683M		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1683					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CAACAGAACCGTGGAGCGATC	0.537000													9	21					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224463599	224463599	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:224463599G>T	ENST00000305409.2	-	2	634	c.402C>A	c.(400-402)ccC>ccA	p.P134P		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	134					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCAAGGCATAGGGCTTATTTT	0.423000													6	151					0.0293803	0.0295506	1	1	0
MGA	23269	broad.mit.edu	37	15	42003160	42003160	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:42003160G>A	ENST00000219905.7	+	8	2878	c.2697G>A	c.(2695-2697)aaG>aaA	p.K899K	MGA_ENST00000566586.1_Silent_p.K899K|MGA_ENST00000570161.1_Silent_p.K899K|MGA_ENST00000389936.4_Silent_p.K899K|MGA_ENST00000545763.1_Silent_p.K899K	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	899						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GAAAGGCAAAGTCTCAAAACA	0.393000													40	63					0	0	1	0	0
DNAJB14	79982	broad.mit.edu	37	4	100851701	100851701	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:100851701C>T	ENST00000442697.2	-	2	365	c.211G>A	c.(211-213)Gat>Aat	p.D71N	DNAJB14_ENST00000471738.1_5'UTR	NM_001031723.2|NM_001278310.1	NP_001026893.1|NP_001265239.1	Q8TBM8	DJB14_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 14	71					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5				OV - Ovarian serous cystadenocarcinoma(123;4.59e-09)		TTGCTTTGATCGCCACTACCT	0.428000													36	77					0	0	1	0	0
SHD	56961	broad.mit.edu	37	19	4288303	4288303	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4288303C>T	ENST00000543264.2	+	5	2243	c.780C>T	c.(778-780)ggC>ggT	p.G260G	SHD_ENST00000600475.1_3'UTR|SHD_ENST00000599689.1_Intron	NM_020209.3	NP_064594.3	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming protein D	260	SH2.									breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|stomach(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAAGGAAGGCAGCTACCTAG	0.577000													12	29					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33768113	33768113	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:33768113C>T	ENST00000285013.6	-	6	2470	c.2195G>A	c.(2194-2196)cGc>cAc	p.R732H	SLFN13_ENST00000533791.1_Missense_Mutation_p.R732H|SLFN13_ENST00000534689.1_Missense_Mutation_p.R414H|SLFN13_ENST00000526861.1_Missense_Mutation_p.R732H|SLFN13_ENST00000542635.1_Missense_Mutation_p.R732H|SLFN13_ENST00000360502.2_Missense_Mutation_p.R414H	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	732						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ATCTGCATTGCGAACTACTCT	0.443000													49	102					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55277797	55277797	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:55277797G>A	ENST00000358193.3	+	6	751	c.697G>A	c.(697-699)Ggc>Agc	p.G233S	C1orf177_ENST00000371273.3_Missense_Mutation_p.G233S	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	233										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						CGGCACCCGCGGCCCCTATGA	0.572000													9	32					0	0	1	0	0
ERRFI1	54206	broad.mit.edu	37	1	8074217	8074217	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:8074217G>A	ENST00000377482.5	-	4	665	c.442C>T	c.(442-444)Cgg>Tgg	p.R148W	ERRFI1_ENST00000474874.1_Intron|ERRFI1_ENST00000469499.1_3'UTR|ERRFI1_ENST00000467067.1_3'UTR	NM_018948.3	NP_061821.1	Q9UJM3	ERRFI_HUMAN	ERBB receptor feedback inhibitor 1	148					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			breast(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(3)|ovary(1)|prostate(1)|skin(2)	16	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CTAGAACCCCGTTCACAAAGA	0.498000													23	45					0	0	1	0	0
RPUSD1	113000	broad.mit.edu	37	16	836869	836869	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:836869C>T	ENST00000561734.1	-	4	712	c.469G>A	c.(469-471)Gca>Aca	p.A157T	RPUSD1_ENST00000567114.1_Missense_Mutation_p.A28T|RPUSD1_ENST00000565809.1_Silent_p.T122T|RPUSD1_ENST00000007264.2_Missense_Mutation_p.A157T			Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing 1	157					pseudouridine synthesis		pseudouridine synthase activity|RNA binding	p.A157T(1)		endometrium(3)|lung(2)|skin(2)	7		Hepatocellular(780;0.00335)				GGATCGCCTGCGTACAGCCCG	0.607000													18	29					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23888705	23888705	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23888705C>T	ENST00000355349.3	-	28	4002	c.3840G>A	c.(3838-3840)ttG>ttA	p.L1280L		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1280					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCTCGGTTTGCAACTTGGCCC	0.602000													28	73					0	0	1	0	0
IL17RA	23765	broad.mit.edu	37	22	17583129	17583129	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:17583129G>A	ENST00000319363.6	+	7	832	c.699G>A	c.(697-699)ctG>ctA	p.L233L		NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	233					fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		ACCAGATCCTGCTGACCAGTT	0.552000													48	57					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86697775	86697775	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:86697775G>A	ENST00000441037.2	+	3	334	c.239G>A	c.(238-240)cGt>cAt	p.R80H	AGBL1_ENST00000421325.2_Missense_Mutation_p.R80H	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	80					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TGGGCTCTGCGTGTGTTTGCC	0.537000													14	13					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61829572	61829572	+	Silent	SNP	G	G	A	rs141012790		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:61829572G>A	ENST00000280772.1	-	37	11258	c.11067C>T	c.(11065-11067)agC>agT	p.S3689S	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3689					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GACACTCTCCGCTGGTCGGGA	0.532000													4	79					0	0	1	0	0
DNAJA1	3301	broad.mit.edu	37	9	33036611	33036611	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:33036611C>T	ENST00000330899.4	+	7	981	c.798C>T	c.(796-798)ctC>ctT	p.L266L	DNAJA1_ENST00000544625.1_Silent_p.L109L|DNAJA1_ENST00000495015.1_3'UTR	NM_001539.2	NP_001530.1	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	266					protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding			large_intestine(2)|ovary(1)|skin(3)	6			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		ACATACAGCTCGTTGAAGCAC	0.408000													9	25					0	0	1	0	0
RBFOX2	23543	broad.mit.edu	37	22	36142522	36142522	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36142522G>A	ENST00000405409.2	-	10	1342	c.974C>T	c.(973-975)aCg>aTg	p.T325M	RBFOX2_ENST00000438146.2_Silent_p.D412D|RBFOX2_ENST00000414461.2_Missense_Mutation_p.T328M|RBFOX2_ENST00000397303.2_Silent_p.D318D|RBFOX2_ENST00000449924.2_Silent_p.D341D|RBFOX2_ENST00000359369.4_Missense_Mutation_p.T328M|RBFOX2_ENST00000416721.2_Silent_p.D337D|RBFOX2_ENST00000262829.7_Silent_p.D319D	NM_001031695.2|NM_001082576.1|NM_001082577.1|NM_014309.2	NP_001026865.1|NP_001076045.1|NP_001076046.1|NP_055124.1	O43251	RFOX2_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 2	0	Ala-rich.				estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding			endometrium(4)|large_intestine(7)|lung(7)	18						GTACATACCCGTCACTGTAag	0.547000													28	40					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169511013	169511013	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:169511013T>C	ENST00000367796.3	-	13	3531	c.3330A>G	c.(3328-3330)tcA>tcG	p.S1110S	F5_ENST00000367797.3_Silent_p.S1105S			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1105	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CAGTGTCATTTGAGGAATTCT	0.463000													4	79					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25665888	25665888	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:25665888C>T	ENST00000382051.3	+	4	365	c.315C>T	c.(313-315)ctC>ctT	p.L105L	SLC34A2_ENST00000503434.1_Silent_p.L104L|SLC34A2_ENST00000504570.1_Silent_p.L104L	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	105					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TTTTACTTCTCGGATTTCTCT	0.507000			T	ROS1	NSCLC								32	44					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66431254	66431254	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:66431254G>A	ENST00000383703.3	-	19	3336	c.2733C>T	c.(2731-2733)tgC>tgT	p.C911C	LRIG1_ENST00000496559.2_5'UTR|SLC25A26_ENST00000536651.1_3'UTR|LRIG1_ENST00000273261.3_Silent_p.C934C			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	934				M -> I (in Ref. 2; BAB40659).		integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CTTCGGTGTTGCAGTCACTGC	0.607000													14	23					0	0	1	0	0
AKAP10	11216	broad.mit.edu	37	17	19827781	19827781	+	Missense_Mutation	SNP	G	G	A	rs142084873		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:19827781G>A	ENST00000225737.6	-	11	1848	c.1691C>T	c.(1690-1692)gCg>gTg	p.A564V	AKAP10_ENST00000395536.3_Missense_Mutation_p.A506V	NM_007202.3	NP_009133.2	O43572	AKA10_HUMAN	A kinase (PRKA) anchor protein 10	564					blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	21	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					CACAATTATCGCTTCATCAAA	0.353000													27	25					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149485513	149485513	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149485513G>A	ENST00000378016.2	+	0	3919							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCAGGTGGTGGCCTGTGTGGA	0.657000													6	10					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129899719	129899719	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:129899719C>T	ENST00000368654.3	-	14	9883	c.9508G>A	c.(9508-9510)Gca>Aca	p.A3170T	MKI67_ENST00000368653.3_Missense_Mutation_p.A2810T	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	3170					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTCTCCTCTGCCACCTTAGGC	0.507000													52	65					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45773734	45773734	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:45773734G>A	ENST00000397928.1	+	1	596	c.151G>A	c.(151-153)Ggc>Agc	p.G51S	TRPM2_ENST00000397932.2_Missense_Mutation_p.G51S|TRPM2_ENST00000300481.9_Missense_Mutation_p.G51S|TRPM2_ENST00000300482.5_Missense_Mutation_p.G51S	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	51						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GTGCCCCTTCGGCAACAATGA	0.607000													5	4					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10300214	10300214	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:10300214C>T	ENST00000403437.2	-	31	4362	c.4268G>A	c.(4267-4269)cGg>cAg	p.R1423Q	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1423					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						ATTCTGGAGCCGCTGCTTCGT	0.488000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				4	73					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17856298	17856298	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:17856298C>A	ENST00000378814.5	-	5	275	c.276G>T	c.(274-276)caG>caT	p.Q92H	KIF13A_ENST00000378843.2_Missense_Mutation_p.Q92H|KIF13A_ENST00000378826.2_Missense_Mutation_p.Q92H|KIF13A_ENST00000378816.5_Missense_Mutation_p.Q92H|KIF13A_ENST00000259711.6_Missense_Mutation_p.Q92H	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	92	Kinesin-motor.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CATTATACCCCTGAAAGGCTT	0.363000													9	29					0.00448238	0.00453641	1	1	0
LYZL2	119180	broad.mit.edu	37	10	30915180	30915180	+	Missense_Mutation	SNP	G	G	A	rs144040075	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:30915180G>A	ENST00000375318.2	-	3	346	c.290C>T	c.(289-291)gCg>gTg	p.A97V		NM_183058.2	NP_898881.2	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	51					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			NS(2)|central_nervous_system(1)|large_intestine(1)|lung(14)|prostate(1)	19		Prostate(175;0.151)				CTCATAATACGCCATGCAGAT	0.552000													10	32					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98558974	98558974	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:98558974C>A	ENST00000359863.4	+	45	6768	c.6559C>A	c.(6559-6561)Ctc>Atc	p.L2187I	TRRAP_ENST00000355540.3_Missense_Mutation_p.L2169I|TRRAP_ENST00000446306.3_Missense_Mutation_p.L2168I	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2187	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCCAGCCATCCTCAGTAGCTT	0.552000													37	41					2.32173e-10	2.48086e-10	1	1	0
RARB	5915	broad.mit.edu	37	3	25470290	25470290	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:25470290C>T	ENST00000330688.4	+	1	489	c.68C>T	c.(67-69)cCg>cTg	p.P23L	RARB_ENST00000437042.2_Intron|RARB_ENST00000462272.1_3'UTR|RARB_ENST00000404969.1_Intron	NM_000965.3	NP_000956.2	P10826	RARB_HUMAN	retinoic acid receptor, beta	0	Modulating.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|kidney(1)|large_intestine(10)|lung(11)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	28					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	ACTGCGAGTCCGTCTTCCTGC	0.483000													40	66					0	0	1	0	0
ASB1	51665	broad.mit.edu	37	2	239344591	239344591	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:239344591G>A	ENST00000264607.4	+	3	678	c.431G>A	c.(430-432)cGc>cAc	p.R144H	ASB1_ENST00000409297.1_Intron	NM_001040445.1	NP_001035535.1	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box containing 1	144					intracellular signal transduction|negative regulation of cytokine biosynthetic process					breast(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		CGGCACCATCGCAGCACCCCT	0.652000													4	9					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118368689	118368689	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118368689G>A	ENST00000534358.1	+	21	5726	c.5703G>A	c.(5701-5703)tgG>tgA	p.W1901*	KMT2A_ENST00000389506.5_Nonsense_Mutation_p.W1898*|KMT2A_ENST00000354520.4_Nonsense_Mutation_p.W1860*	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AAAATGAGTGGACACATGTAA	0.403000													14	109					0	0	1	0	0
TRAF3IP2	10758	broad.mit.edu	37	6	111880685	111880685	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:111880685G>A	ENST00000368761.5	-	9	2099	c.1621C>T	c.(1621-1623)Ctg>Ttg	p.L541L	TRAF3IP2_ENST00000359831.4_Silent_p.L540L|TRAF3IP2-AS1_ENST00000449449.2_RNA|TRAF3IP2-AS1_ENST00000440395.1_RNA|TRAF3IP2-AS1_ENST00000532353.1_RNA|TRAF3IP2_ENST00000340026.6_Silent_p.L550L|TRAF3IP2_ENST00000368735.1_Silent_p.L85L|TRAF3IP2-AS1_ENST00000442928.2_RNA|TRAF3IP2_ENST00000368731.2_5'UTR|TRAF3IP2-AS1_ENST00000438298.2_RNA|TRAF3IP2-AS1_ENST00000456352.2_RNA|TRAF3IP2_ENST00000392556.4_Silent_p.L129L	NM_001164281.2|NM_147686.3	NP_001157753.1|NP_679211.2	O43734	CIKS_HUMAN	TRAF3 interacting protein 2	550	SEFIR.				intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	18		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		AGCAGCCGCAGCAGGATGTTT	0.552000													44	54					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38860668	38860668	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:38860668C>T	ENST00000409235.3	+	27	3192	c.3077C>T	c.(3076-3078)gCc>gTc	p.A1026V	CATSPERG_ENST00000410018.1_Missense_Mutation_p.A986V|CATSPERG_ENST00000215069.4_3'UTR	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	1026					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						GGCATCTTTGCCCCTGAATTC	0.557000													50	99					0	0	1	0	0
ZNF230	7773	broad.mit.edu	37	19	44514886	44514886	+	Missense_Mutation	SNP	G	G	A	rs151068123	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:44514886G>A	ENST00000429154.2	+	5	923	c.695G>A	c.(694-696)gGc>gAc	p.G232D		NM_006300.3	NP_006291.2	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)|stomach(3)|urinary_tract(2)	22		Prostate(69;0.0352)				TGTGGGAAAGGCTTCAGATGT	0.443000													33	54					0	0	1	0	0
AC004381.6	0	broad.mit.edu	37	16	20833204	20833204	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:20833204C>T	ENST00000261377.6	+	6	805	c.596C>T	c.(595-597)aCg>aTg	p.T199M	AC004381.6_ENST00000564274.1_Missense_Mutation_p.T199M|AC004381.6_ENST00000348433.6_Missense_Mutation_p.T199M|ERI2_ENST00000564349.1_Intron|AC004381.6_ENST00000567297.1_3'UTR	NM_001199053.1|NM_030941.2	NP_001185982.1|NP_112203.2																					GAAATGAGAACGTTTCACTTT	0.388000													19	29					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153694316	153694316	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153694316G>A	ENST00000369682.3	+	14	2746	c.2571G>A	c.(2569-2571)cgG>cgA	p.R857R		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	857	IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GAGGCACCCGGGTCACCATCG	0.647000													13	0					0	0	1	0	0
FOLR1	2348	broad.mit.edu	37	11	71903288	71903288	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:71903288C>T	ENST00000393679.1	+	2	507	c.71C>T	c.(70-72)aCa>aTa	p.T24I	FOLR1_ENST00000312293.4_Missense_Mutation_p.T24I|FOLR1_ENST00000393676.3_Missense_Mutation_p.T24I|FOLR1_ENST00000393681.2_Missense_Mutation_p.T24I|RP11-807H22.7_ENST00000378140.3_RNA			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	24					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						GAGGCTCAGACAAGGATTGCA	0.557000													26	35					0	0	1	0	0
VAC14	55697	broad.mit.edu	37	16	70815807	70815807	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:70815807A>G	ENST00000261776.5	-	8	1171	c.911T>C	c.(910-912)gTc>gCc	p.V304A		NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	304					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				GCAGGGCAAGACAGCAGTCAG	0.547000													12	23					0	0	1	0	0
GGA2	23062	broad.mit.edu	37	16	23491977	23491977	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:23491977G>T	ENST00000309859.4	-	10	1077	c.995C>A	c.(994-996)cCt>cAt	p.P332H	GGA2_ENST00000567468.1_Intron	NM_015044.4	NP_055859.1	Q9UJY4	GGA2_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	332	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(48;0.0386)		TCTGGAGACAGGGATGTCTCC	0.502000													15	13					1.15088e-07	1.20771e-07	1	1	0
AFM	173	broad.mit.edu	37	4	74364910	74364910	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:74364910G>T	ENST00000226355.3	+	11	1462	c.1369G>T	c.(1369-1371)Gct>Tct	p.A457S		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	457	Albumin 3.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AATGGTGACAGCTTTCACTAC	0.418000													19	29					9.7654e-05	0.000100207	1	1	0
CDC73	79577	broad.mit.edu	37	1	193094340	193094340	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:193094340G>A	ENST00000367435.3	+	2	414	c.230G>A	c.(229-231)cGt>cAt	p.R77H		NM_024529.4	NP_078805.3	Q6P1J9	CDC73_HUMAN	cell division cycle 73	77					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(14)|ovary(1)|pancreas(1)|parathyroid(51)|skin(1)|upper_aerodigestive_tract(1)	87						TATGTCCGACGTGCAGCTGTA	0.393000													17	31					0	0	1	0	0
MAP3K15	389840	broad.mit.edu	37	X	19482401	19482401	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:19482401G>A	ENST00000338883.4	-	4	648	c.649C>T	c.(649-651)Ctg>Ttg	p.L217L	MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000469203.2_Silent_p.L49L	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	217							ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					AGCGGGCCCAGGATGTTGTCC	0.547000													16	6					0	0	1	0	0
NPHP1	4867	broad.mit.edu	37	2	110936000	110936000	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:110936000T>C	ENST00000418527.1	-	4	359	c.329A>G	c.(328-330)gAg>gGg	p.E110G	NPHP1_ENST00000417665.1_Splice_Site_p.E110_splice|NPHP1_ENST00000393272.3_Splice_Site_p.E110_splice|NPHP1_ENST00000355301.4_Intron|NPHP1_ENST00000316534.4_Splice_Site_p.E110_splice|NPHP1_ENST00000445609.2_Splice_Site_p.E110_splice			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	110					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						GGAAGCATACTCAGTTATATT	0.328000													17	49					0	0	1	0	0
PROKR1	10887	broad.mit.edu	37	2	68882258	68882258	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:68882258C>T	ENST00000303786.3	+	3	1152	c.732C>T	c.(730-732)ccC>ccT	p.P244P	PROKR1_ENST00000394342.2_Silent_p.P244P			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	244						integral to membrane|plasma membrane	neuropeptide Y receptor activity			endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TCGTGGGCCCCGTGGTCACCA	0.567000													21	30					0	0	1	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6896557	6896557	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:6896557C>A	ENST00000419673.2	+	15	1702	c.1485C>A	c.(1483-1485)tcC>tcA	p.S495S	ARHGAP28_ENST00000262227.3_Silent_p.S602S|ARHGAP28_ENST00000531294.1_Silent_p.S490S|ARHGAP28_ENST00000532996.1_Silent_p.S477S|ARHGAP28_ENST00000400091.2_Silent_p.S654S|ARHGAP28_ENST00000418986.1_Silent_p.S495S|ARHGAP28_ENST00000383472.4_Silent_p.S654S|ARHGAP28_ENST00000314319.3_Silent_p.S495S	NM_001010000.2	NP_001010000.1	B4DXL2	B4DXL2_HUMAN	Rho GTPase activating protein 28	477					signal transduction	intracellular				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	37		Colorectal(10;0.168)				CCAAGGTGTCCATGGCCATTC	0.448000													25	34					2.44723e-14	2.66926e-14	1	1	0
ANXA5	308	broad.mit.edu	37	4	122599624	122599624	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:122599624G>A	ENST00000296511.5	-	7	705	c.420C>T	c.(418-420)gaC>gaT	p.D140D	ANXA5_ENST00000509016.1_5'UTR|ANXA5_ENST00000501272.2_Silent_p.D80D|ANXA5_ENST00000515017.1_Silent_p.D40D	NM_001154.3	NP_001145.1	P08758	ANXA5_HUMAN	annexin A5	140					anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			NS(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)	15						CCCCCACCACGTCATCTTCCA	0.393000													5	24					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5428401	5428401	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:5428401G>A	ENST00000341928.2	-	9	1316	c.976C>T	c.(976-978)Cgg>Tgg	p.R326W	EPB41L3_ENST00000400111.3_Missense_Mutation_p.R326W|EPB41L3_ENST00000544123.1_Missense_Mutation_p.R326W|EPB41L3_ENST00000342933.3_Missense_Mutation_p.R326W|EPB41L3_ENST00000540638.2_Missense_Mutation_p.R326W|EPB41L3_ENST00000542652.2_5'UTR	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	326	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity	p.R326R(1)		breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						ATTCGCAGCCGGTCGCGATAT	0.418000													60	103					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13910576	13910576	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13910576C>T	ENST00000254323.2	+	2	385	c.196C>T	c.(196-198)Cgc>Tgc	p.R66C		NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	66							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CGTCCAGAAGCGCATCGTGTT	0.617000													28	55					0	0	1	0	0
ELAC1	55520	broad.mit.edu	37	18	48513361	48513361	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:48513361C>T	ENST00000269466.3	+	4	1105	c.998C>T	c.(997-999)gCa>gTa	p.A333V	RP11-729L2.2_ENST00000588256.1_Intron|RP11-729L2.2_ENST00000590722.2_Intron|SMAD4_ENST00000452201.2_Intron	NM_018696.2	NP_061166.1	Q9H777	RNZ1_HUMAN	elaC ribonuclease Z 1	333					tRNA 3'-trailer cleavage	nucleus	endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			kidney(1)|large_intestine(4)|prostate(1)	6		Colorectal(6;0.0269)|all_epithelial(6;0.0729)		Colorectal(21;0.000943)|COAD - Colon adenocarcinoma(17;0.0398)|READ - Rectum adenocarcinoma(32;0.0894)|STAD - Stomach adenocarcinoma(97;0.18)		GATGGCATTGCAGAACTAAAA	0.428000													19	26					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16918719	16918719	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:16918719C>T	ENST00000524140.2	+	18	4477	c.4059C>T	c.(4057-4059)agC>agT	p.S1353S	NWD1_ENST00000339803.6_Silent_p.S1218S|NWD1_ENST00000523826.1_Silent_p.S1147S|NWD1_ENST00000552788.1_Silent_p.S1353S|NWD1_ENST00000379808.3_Silent_p.S1353S|NWD1_ENST00000549814.1_Silent_p.S1311S	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1353							ATP binding	p.S1353S(1)|p.S1218S(1)		NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CCCTCTCCAGCGTGGCCATTC	0.577000													55	101					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3248153	3248153	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:3248153C>T	ENST00000382004.3	-	16	2158	c.1847G>A	c.(1846-1848)aGt>aAt	p.S616N	RFX3_ENST00000358730.2_Missense_Mutation_p.S616N|RFX3_ENST00000302303.1_Missense_Mutation_p.S616N	NM_134428.1	NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	616					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		GCTAGCAGCACTGCGTAAGGT	0.413000													17	24					0	0	1	0	0
GCNT1	2650	broad.mit.edu	37	9	79117907	79117907	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:79117907T>A	ENST00000442371.1	+	3	1549	c.610T>A	c.(610-612)Tat>Aat	p.Y204N	GCNT1_ENST00000376730.4_Missense_Mutation_p.Y204N|GCNT1_ENST00000536223.1_Missense_Mutation_p.Y204N|GCNT1_ENST00000444201.2_Missense_Mutation_p.Y204N	NM_001097634.1	NP_001091103.1	Q02742	GCNT1_HUMAN	glucosaminyl (N-acetyl) transferase 1, core 2	204	Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(11)|prostate(2)|urinary_tract(1)	30						GAAGGATCTCTATGCAATGAG	0.423000													46	50					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118390416	118390416	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118390416C>T	ENST00000534358.1	+	32	11253	c.11230C>T	c.(11230-11232)Cga>Tga	p.R3744*	RP11-770J1.3_ENST00000554407.1_RNA|RP11-770J1.3_ENST00000525992.2_RNA|RP11-770J1.3_ENST00000556583.1_RNA|RP11-770J1.3_ENST00000528578.1_RNA|RP11-770J1.3_ENST00000532597.1_RNA|KMT2A_ENST00000389506.5_Nonsense_Mutation_p.R3741*|KMT2A_ENST00000354520.4_Nonsense_Mutation_p.R3703*	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CAAGCACTGTCGAAATTACAA	0.522000													6	63					0	0	1	0	0
DUSP16	80824	broad.mit.edu	37	12	12630760	12630760	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:12630760C>T	ENST00000228862.2	-	7	1636	c.1005G>A	c.(1003-1005)acG>acA	p.T335T	DUSP16_ENST00000298573.4_3'UTR	NM_030640.2	NP_085143.1	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	335					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(7)|kidney(2)|large_intestine(6)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(3)	26		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		GACTGAGGGGCGTCTCGCTTT	0.622000													24	30					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119964454	119964454	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:119964454C>A	ENST00000543831.1	+	4	579	c.330C>A	c.(328-330)gcC>gcA	p.A110A	HSD3B2_ENST00000369416.3_Silent_p.A110A	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	110					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	TGTTGGAGGCCTGTGTCCAAG	0.537000													72	90					3.12118e-38	3.50628e-38	1	1	0
ANK1	286	broad.mit.edu	37	8	41548012	41548012	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:41548012G>A	ENST00000396942.1	-	32	4047	c.3964C>T	c.(3964-3966)Cgt>Tgt	p.R1322C	ANK1_ENST00000347528.4_Missense_Mutation_p.R1322C|ANK1_ENST00000289734.7_Missense_Mutation_p.R1322C|ANK1_ENST00000265709.8_Missense_Mutation_p.R1363C|ANK1_ENST00000396945.1_Missense_Mutation_p.R1322C|ANK1_ENST00000352337.4_Missense_Mutation_p.R1322C|ANK1_ENST00000379758.2_Missense_Mutation_p.R1322C			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1322					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ATGGCCAGACGGTTCTCCCGA	0.567000													4	33					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60463394	60463394	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:60463394G>A	ENST00000371201.3	-	11	1474	c.1367C>T	c.(1366-1368)tCc>tTc	p.S456F	C1orf87_ENST00000395552.1_Missense_Mutation_p.S90F|C1orf87_ENST00000486478.1_5'UTR|C1orf87_ENST00000450089.2_Missense_Mutation_p.S227F	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	456							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GAAGGGCTGGGAGACTGGCCT	0.498000													29	48					0	0	1	0	0
ABCF1	23	broad.mit.edu	37	6	30551625	30551625	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30551625C>A	ENST00000326195.8	+	12	1172	c.1060C>A	c.(1060-1062)Ctg>Atg	p.L354M	ABCF1_ENST00000396515.4_Intron|ABCF1_ENST00000376545.3_Missense_Mutation_p.L316M	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	354	ABC transporter 1.				inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						CAACCGAGCCCTGAGCATCCC	0.537000													20	27					1.66031e-10	1.77558e-10	1	1	0
RIN1	9610	broad.mit.edu	37	11	66102431	66102431	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66102431C>T	ENST00000311320.4	-	6	965	c.839G>A	c.(838-840)cGg>cAg	p.R280Q	RIN1_ENST00000530056.1_Missense_Mutation_p.R175Q|RIN1_ENST00000424433.2_Missense_Mutation_p.R175Q|RP11-867G23.12_ENST00000526655.1_RNA	NM_004292.2	NP_004283.2	Q13671	RIN1_HUMAN	Ras and Rab interactor 1	280					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(1)	14						AGGGGGCAGCCGCTCTGTCTG	0.701000													4	7					0	0	1	0	0
C2CD2L	9854	broad.mit.edu	37	11	118978777	118978777	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118978777C>T	ENST00000336702.3	+	1	685	c.326C>T	c.(325-327)gCg>gTg	p.A109V	DPAGT1_ENST00000409993.2_5'UTR	NM_014807.3	NP_055622.3	O14523	C2C2L_HUMAN	C2CD2-like	109						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)	13						TGGGTGCGAGCGCTGAACGAG	0.657000													11	28					0	0	1	0	0
ARHGEF25	115557	broad.mit.edu	37	12	58009785	58009785	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:58009785C>T	ENST00000286494.4	+	13	1865	c.1405C>T	c.(1405-1407)Cgg>Tgg	p.R469W	AC025165.8_ENST00000593846.1_RNA|AC025165.8_ENST00000356672.3_RNA|ARHGEF25_ENST00000333972.7_Missense_Mutation_p.R508W|AC025165.8_ENST00000444467.1_RNA	NM_182947.3	NP_891992.2	Q86VW2	ARHGP_HUMAN	Rho guanine nucleotide exchange factor (GEF) 25	469	Sufficient to bind activated GNAQ.				regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	28						GGAGAGCCAACGGGACTTCCT	0.572000													50	56					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21445155	21445155	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:21445155G>A	ENST00000307378.6	-	13	2273	c.1553C>T	c.(1552-1554)gCg>gTg	p.A518V	SLCO1A2_ENST00000452078.1_Missense_Mutation_p.A518V|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.A516V|SLCO1A2_ENST00000458504.1_Missense_Mutation_p.A386V|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.A386V	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	518					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						ACTGCTCATCGCTGACAAGAT	0.383000													15	17					0	0	1	0	0
PAF1	54623	broad.mit.edu	37	19	39879256	39879256	+	Silent	SNP	C	C	T	rs143167089	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39879256C>T	ENST00000221265.3	-	10	1131	c.801G>A	c.(799-801)acG>acA	p.T267T	PAF1_ENST00000595564.1_Silent_p.T257T|PAF1_ENST00000221266.7_Silent_p.T234T	NM_019088.3	NP_061961.2	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	267					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|urinary_tract(2)	17	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GTTTCTTCAACGTCTCTTCTA	0.512000													13	61					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32136765	32136765	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:32136765C>A	ENST00000312561.4	+	4	3290	c.2876C>A	c.(2875-2877)cCt>cAt	p.P959H	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		AAAGATAAACCTGTACAGTGC	0.358000													35	33					3.93418e-24	4.38783e-24	1	1	0
IRAK2	3656	broad.mit.edu	37	3	10219598	10219598	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:10219598G>A	ENST00000256458.4	+	2	261	c.171G>A	c.(169-171)acG>acA	p.T57T		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	57	Death.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						TGAGCATCACGCGGGAGCTGC	0.637000													18	38					0	0	1	0	0
WDR24	84219	broad.mit.edu	37	16	735360	735360	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:735360T>C	ENST00000293883.4	-	7	2675	c.1916A>G	c.(1915-1917)gAc>gGc	p.D639G	WDR24_ENST00000248142.6_Missense_Mutation_p.D769G	NM_032259.2	NP_115635.1	Q96S15	WDR24_HUMAN	WD repeat domain 24	769										breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(3)	19		Hepatocellular(780;0.0218)				GTGCAGCATGTCGCGCACCAG	0.647000													11	19					0	0	1	0	0
GRAMD1A	57655	broad.mit.edu	37	19	35510307	35510307	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:35510307C>T	ENST00000599564.1	+	14	1677	c.1606C>T	c.(1606-1608)Cgc>Tgc	p.R536C	GRAMD1A_ENST00000504615.2_Missense_Mutation_p.R215C|CTD-2527I21.14_ENST00000605640.1_RNA|GRAMD1A_ENST00000411896.2_Missense_Mutation_p.R442C|GRAMD1A_ENST00000317991.5_Missense_Mutation_p.R449C			Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A	449						integral to membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCTGTTCCGGCGCGGCCCCCA	0.687000													21	34					0	0	1	0	0
ABR	29	broad.mit.edu	37	17	994938	994938	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:994938G>A	ENST00000544583.2	-	4	959	c.360C>T	c.(358-360)agC>agT	p.S120S	ABR_ENST00000574437.1_Silent_p.S120S|ABR_ENST00000291107.2_Silent_p.S129S|ABR_ENST00000302538.5_Silent_p.S166S	NM_001159746.2	NP_001153218.1	Q12979	ABR_HUMAN	active BCR-related	166	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		TGGTGACCTGGCTGTCCCACT	0.567000													31	37					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169195115	169195115	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:169195115G>A	ENST00000393743.3	-	17	2715	c.2424C>T	c.(2422-2424)gaC>gaT	p.D808D		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	808	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CGACCACCCCGTCGTCGCTCT	0.448000													5	68					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124390529	124390529	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:124390529G>A	ENST00000338354.3	+	46	5797	c.5691G>A	c.(5689-5691)ggG>ggA	p.G1897G	DMBT1_ENST00000344338.3_Silent_p.G1887G|DMBT1_ENST00000368909.3_Silent_p.G1897G|DMBT1_ENST00000368955.3_Silent_p.G1887G|DMBT1_ENST00000359586.6_Silent_p.G617G|DMBT1_ENST00000330163.4_Silent_p.G1269G|DMBT1_ENST00000368956.2_Silent_p.G1269G			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1897	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TATGTGCCGGGCGTGTAGAAA	0.488000													5	42					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83841913	83841913	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:83841913T>C	ENST00000349129.2	+	18	2895	c.2635T>C	c.(2635-2637)Tgg>Cgg	p.W879R	DOPEY1_ENST00000237163.5_Missense_Mutation_p.W860R|DOPEY1_ENST00000369739.3_Missense_Mutation_p.W870R	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	879					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTTAACATTGTGGGACCAGTT	0.353000													35	48					0	0	1	0	0
FOXA3	3171	broad.mit.edu	37	19	46375966	46375966	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:46375966G>A	ENST00000302177.2	+	2	900	c.703G>A	c.(703-705)Ggg>Agg	p.G235R		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	235					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		GAACGGGACAGGGTCTGCTGC	0.682000													9	8					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114238872	114238872	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:114238872C>A	ENST00000357077.4	+	25	2756	c.2703C>A	c.(2701-2703)tcC>tcA	p.S901S	ANK2_ENST00000509550.1_Silent_p.S110S|ANK2_ENST00000264366.6_Silent_p.S901S|ANK2_ENST00000394537.3_Silent_p.S901S|ANK2_ENST00000506722.1_Silent_p.S880S	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	901					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GCCTTCGATCCTTCAGTTCCG	0.527000													10	16					2.80697e-09	2.97546e-09	1	1	0
DOCK9	23348	broad.mit.edu	37	13	99481710	99481710	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:99481710C>T	ENST00000376460.1	-	43	4827	c.4747G>A	c.(4747-4749)Gcc>Acc	p.A1583T	DOCK9_ENST00000339416.2_Missense_Mutation_p.A1584T|DOCK9_ENST00000448493.2_3'UTR	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1584	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTCATCTGGGCGGTGGCCATT	0.547000													9	11					0	0	1	0	0
EFCAB14	9813	broad.mit.edu	37	1	47144280	47144280	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47144280G>A	ENST00000371933.3	-	11	2317	c.1341C>T	c.(1339-1341)ggC>ggT	p.G447G	EFCAB14-AS1_ENST00000418985.1_RNA|EFCAB14_ENST00000544071.1_Intron|EFCAB14-AS1_ENST00000442839.1_RNA	NM_014774.2	NP_055589.1			EF-hand calcium binding domain 14																		CCACGTCCTGGCCAGTCTTGC	0.423000													23	42					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3084089	3084089	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:3084089C>T	ENST00000397461.1	+	20	2878	c.2494C>T	c.(2494-2496)Cga>Tga	p.R832*	CNTN4-AS1_ENST00000442749.2_RNA|CNTN4_ENST00000397459.2_Nonsense_Mutation_p.R504*|CNTN4_ENST00000358480.3_Nonsense_Mutation_p.R613*|CNTN4_ENST00000448906.2_Nonsense_Mutation_p.R504*|CNTN4_ENST00000418658.1_Nonsense_Mutation_p.R832*|CNTN4_ENST00000427331.1_Nonsense_Mutation_p.R832*	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	832	Fibronectin type-III 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GAATAGAGGACGAATACAAGG	0.458000													19	27					0	0	1	0	0
DIS3L2	129563	broad.mit.edu	37	2	233127987	233127987	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:233127987G>A	ENST00000325385.7	+	13	1772	c.1496G>A	c.(1495-1497)aGc>aAc	p.S499N	DIS3L2_ENST00000273009.6_Missense_Mutation_p.S499N|DIS3L2_ENST00000409307.1_Missense_Mutation_p.S499N	NM_152383.4	NP_689596.4	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like 2	499							exonuclease activity|ribonuclease activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(2)|urinary_tract(1)	40		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CATGCACAGAGCATGATTGAA	0.512000													14	25					0	0	1	0	0
DKFZP761J1410	0	broad.mit.edu	37	19	11470258	11470258	+	Silent	SNP	G	G	A	rs145767785		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:11470258G>A	ENST00000251473.5	+	4	493	c.117G>A	c.(115-117)acG>acA	p.T39T	DKFZP761J1410_ENST00000591608.1_Intron|DKFZP761J1410_ENST00000586431.1_3'UTR	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					TGGAGTTCACGGACACCTTCC	0.622000													17	18					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62297786	62297786	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:62297786G>T	ENST00000378024.4	-	5	4377	c.4103C>A	c.(4102-4104)gCt>gAt	p.A1368D	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1368					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CACATCTGGAGCACTAATGTC	0.493000													5	276					3.59834e-05	3.7043e-05	1	1	0
ZCCHC14	23174	broad.mit.edu	37	16	87451092	87451092	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:87451092C>T	ENST00000268616.4	-	8	1163	c.946G>A	c.(946-948)Gtc>Atc	p.V316I		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	316					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		TGCTTAAAGACGGGGTAATAC	0.507000											OREG0024030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	75					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10800531	10800531	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:10800531C>T	ENST00000361367.2	+	25	3827	c.3401C>T	c.(3400-3402)tCg>tTg	p.S1134L		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	1134	Ser-rich.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GATCACGAATCGGAGAGAGGA	0.507000													27	52					0	0	1	0	0
GTDC2	0	broad.mit.edu	37	3	43122910	43122910	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:43122910G>A	ENST00000344697.2	-	2	359	c.14C>T	c.(13-15)gCg>gTg	p.A5V	GTDC2_ENST00000441964.1_Missense_Mutation_p.A5V	NM_032806.4	NP_116195.2																					GTTGAACACCGCCGAGAGGTG	0.637000													6	5					0	0	1	0	0
GPR18	0	broad.mit.edu	37	13	99907245	99907245	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:99907245C>A	ENST00000340807.3	-	3	1438	c.882G>T	c.(880-882)caG>caT	p.Q294H	GPR18_ENST00000397470.2_Missense_Mutation_p.Q294H|UBAC2_ENST00000403766.3_Intron|UBAC2_ENST00000376440.2_Intron|GPR18_ENST00000397473.2_Missense_Mutation_p.Q294H			Q14330	GPR18_HUMAN	G protein-coupled receptor 18	294						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)	10	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	TGACTCGAGCCTGAAATTGTT	0.433000													24	39					2.89027e-11	3.10618e-11	1	1	0
SEL1L3	23231	broad.mit.edu	37	4	25823678	25823678	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:25823678G>A	ENST00000399878.3	-	7	1352	c.1230C>T	c.(1228-1230)ggC>ggT	p.G410G	SEL1L3_ENST00000264868.5_Silent_p.G375G|SEL1L3_ENST00000502949.1_Silent_p.G257G	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	410						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						ACCCTTCAATGCCAGCCACAT	0.507000													20	20					0	0	1	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65242086	65242086	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:65242086G>A	ENST00000380230.3	+	14	1405	c.1376G>A	c.(1375-1377)gGc>gAc	p.G459D	ANKDD1A_ENST00000395723.1_Missense_Mutation_p.G336D|ANKDD1A_ENST00000357698.3_Missense_Mutation_p.G427D|ANKDD1A_ENST00000395720.1_Missense_Mutation_p.G459D	NM_182703.3	NP_874362.3	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	459	Death.				signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						CAGGAGCACGGCCACCGAATG	0.622000													25	35					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	110223177	110223177	+	Translation_Start_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:110223177G>A	ENST00000399132.1	-	0	529				COL25A1_ENST00000399127.1_De_novo_Start_InFrame|COL25A1_ENST00000399126.1_De_novo_Start_InFrame	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1							collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CAGCAGCATCGTGGCGGGGTC	0.602000													16	17					0	0	1	0	0
ALKBH1	8846	broad.mit.edu	37	14	78161199	78161199	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:78161199G>A	ENST00000216489.3	-	3	352	c.337C>T	c.(337-339)Cac>Tac	p.H113Y	ALKBH1_ENST00000554097.1_5'UTR	NM_006020.2	NP_006011.2	Q13686	ALKB1_HUMAN	alkB, alkylation repair homolog 1 (E. coli)	113					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	9			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		TTCACCCAGTGCCACTGGTAA	0.418000													27	34					0	0	1	0	0
GIPC3	126326	broad.mit.edu	37	19	3586531	3586531	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3586531G>T	ENST00000322315.5	+	2	309	c.264G>T	c.(262-264)atG>atT	p.M88I		NM_133261.2	NP_573568.1	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	88										breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGTGGACATGCAGAAGCTCC	0.582000											OREG0025154	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	64					0.0581538	0.0584448	1	1	0
KIAA2022	340533	broad.mit.edu	37	X	73965443	73965443	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:73965443C>T	ENST00000373468.1	-	2	694	c.43G>A	c.(43-45)Gga>Aga	p.G15R	KIAA2022_ENST00000055682.5_Missense_Mutation_p.G15R			Q5QGS0	K2022_HUMAN	KIAA2022	15					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						GTGTTTTCTCCGTTGGCTGAG	0.363000													18	3					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27784466	27784466	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:27784466C>T	ENST00000261588.4	+	23	4264	c.4245C>T	c.(4243-4245)taC>taT	p.Y1415Y		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1415										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						ACCCCTACTACATCGGCCTCA	0.473000													5	29					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184297350	184297350	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:184297350C>T	ENST00000330394.2	+	10	2339	c.1887C>T	c.(1885-1887)gaC>gaT	p.D629D	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	629						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			AGGAGATCGACGTGTCCTGCG	0.547000													20	21					0	0	1	0	0
CSTF2T	23283	broad.mit.edu	37	10	53459282	53459282	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:53459282C>T	ENST00000331173.4	-	1	73	c.28G>A	c.(28-30)Gca>Aca	p.A10T	PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373980.4_Intron|PRKG1_ENST00000373985.1_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	10					mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		CGATCCATTGCCGGGTCTCTC	0.537000													38	70					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48686637	48686637	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:48686637G>A	ENST00000544264.1	-	18	6779	c.6499C>T	c.(6499-6501)Cgg>Tgg	p.R2167W	CELSR3_ENST00000164024.4_Missense_Mutation_p.R2162W			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2162					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCACACAGCCGCACAGCAGCA	0.622000													4	6					0	0	1	0	0
COG6	57511	broad.mit.edu	37	13	40263922	40263922	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:40263922T>C	ENST00000416691.1	+	11	1135	c.1035T>C	c.(1033-1035)gtT>gtC	p.V345V	COG6_ENST00000455146.3_Silent_p.V345V	NM_001145079.1	NP_001138551.1	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6	345					protein transport	Golgi membrane|Golgi transport complex				NS(1)|kidney(2)|large_intestine(5)|lung(4)|skin(1)	13		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		TTCAAGAAGTTGTTGGGCATA	0.274000													15	21					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348870	89348870	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:89348870G>A	ENST00000301030.4	-	9	4540	c.4080C>T	c.(4078-4080)agC>agT	p.S1360S	ANKRD11_ENST00000378330.2_Silent_p.S1360S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1360	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTCGGTCGTGGCTCTTCTTGG	0.567000													16	44					0	0	1	0	0
POU2F1	5451	broad.mit.edu	37	1	167367303	167367303	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:167367303G>A	ENST00000367862.5	+	11	1404	c.1169G>A	c.(1168-1170)cGt>cAt	p.R390H	POU2F1_ENST00000420254.3_Missense_Mutation_p.R378H|POU2F1_ENST00000367866.2_Missense_Mutation_p.R401H|POU2F1_ENST00000541643.3_Missense_Mutation_p.R378H|POU2F1_ENST00000429375.2_Missense_Mutation_p.R338H|POU2F1_ENST00000367865.1_3'UTR	NM_001198783.1	NP_001185712.1	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	378					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	30						GGCTTGAGCCGTAGGAGGAAG	0.463000													7	41					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55930778	55930778	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:55930778G>A	ENST00000389286.4	-	14	2468	c.2421C>T	c.(2419-2421)agC>agT	p.S807S		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	807	Fibronectin type-III 4.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		AGACTACAGGGCTCCAAGGAC	0.353000													15	23					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166935682	166935682	+	Missense_Mutation	SNP	G	G	A	rs114287070	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:166935682G>A	ENST00000061240.2	+	8	1659	c.1012G>A	c.(1012-1014)Gca>Aca	p.A338T	TLL1_ENST00000507499.1_Missense_Mutation_p.A338T|TLL1_ENST00000513213.1_Missense_Mutation_p.A338T	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	338	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AGGAGATATCGCACAGGCAAG	0.458000													38	59					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46067556	46067556	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:46067556G>A	ENST00000295452.4	-	4	534	c.367C>T	c.(367-369)Cgt>Tgt	p.R123C		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	123					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AATTTTAAACGACTGTCAAAC	0.289000													10	18					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148601523	148601523	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:148601523T>C	ENST00000296046.3	+	9	954	c.902T>C	c.(901-903)aTc>aCc	p.I301T	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	301				I -> T (in Ref. 5; AAB22578).	proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			AAGGTTTACATCACCTTCCAT	0.433000													21	36					0	0	1	0	0
SIX2	10736	broad.mit.edu	37	2	45236004	45236004	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:45236004C>T	ENST00000303077.6	-	1	565	c.246G>A	c.(244-246)aaG>aaA	p.K82K		NM_016932.4	NP_058628.3	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	82						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(6)|large_intestine(3)|lung(8)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	22		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCTGCTGCAGCTTGGCGTGGT	0.652000													35	43					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30680284	30680284	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30680284C>T	ENST00000376406.3	-	5	2082	c.1435G>A	c.(1435-1437)Gcc>Acc	p.A479T	MDC1_ENST00000376405.2_Missense_Mutation_p.A479T|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	479	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						CTAACAAGGGCTCTAATCTTT	0.502000								Other conserved DNA damage response genes					36	59					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87133634	87133634	+	Silent	SNP	C	C	A	rs149482536	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:87133634C>A	ENST00000265724.3	-	29	4185	c.3768G>T	c.(3766-3768)acG>acT	p.T1256T	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Silent_p.T1192T	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1256	ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GCTGCTGATGCGTGCCATGCT	0.493000													28	44					9.93527e-08	1.04484e-07	1	1	0
SETD7	80854	broad.mit.edu	37	4	140450287	140450287	+	Missense_Mutation	SNP	C	C	T	rs76651232	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:140450287C>T	ENST00000274031.3	-	4	1096	c.460G>A	c.(460-462)Gca>Aca	p.A154T	SETD7_ENST00000506866.2_Missense_Mutation_p.A154T	NM_030648.2	NP_085151.1	Q8WTS6	SETD7_HUMAN	SET domain containing (lysine methyltransferase) 7	154					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	8	all_hematologic(180;0.156)					CCATAAAGTGCGGTCCTCTCA	0.468000													40	44					0	0	1	0	0
SGTA	6449	broad.mit.edu	37	19	2762618	2762618	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2762618C>T	ENST00000221566.2	-	7	683	c.522G>A	c.(520-522)aaG>aaA	p.K174K		NM_003021.3	NP_003012.1	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	174					interspecies interaction between organisms	cytoplasm	protein binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCCACGTGCTTGTTGAGGC	0.632000													46	64					0	0	1	0	0
GALNT3	2591	broad.mit.edu	37	2	166611442	166611442	+	Splice_Site	SNP	G	G	A	rs144331248	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:166611442G>A	ENST00000392701.3	-	8	2299	c.1524_splice	c.e8+1	p.Y508_splice	GALNT3_ENST00000409882.1_Splice_Site_p.Y246_splice	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	508	Ricin B-type lectin.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						AAATACTCACGTATCCAGATA	0.333000													25	18					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14768435	14768435	+	Missense_Mutation	SNP	G	G	A	rs149516015		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:14768435G>A	ENST00000253697.3	+	11	2046	c.1594G>A	c.(1594-1596)Gac>Aac	p.D532N	C3orf20_ENST00000435614.1_Missense_Mutation_p.D410N|C3orf20_ENST00000412910.1_Missense_Mutation_p.D410N	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	532						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						CAACATGGACGACAAGGTGTA	0.527000													16	19					0	0	1	0	0
SNX20	124460	broad.mit.edu	37	16	50707468	50707468	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:50707468G>A	ENST00000330943.4	-	4	971	c.800C>T	c.(799-801)gCg>gTg	p.A267V	SNX20_ENST00000300590.3_Intron|SNX20_ENST00000423026.2_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	267					cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						CAGCAGAGGCGCATAGTAGCG	0.721000													11	14					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139529239	139529239	+	Missense_Mutation	SNP	C	C	T	rs61733586	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:139529239C>T	ENST00000263552.6	+	5	591	c.53C>T	c.(52-54)aCg>aTg	p.T18M	TBXAS1_ENST00000411653.1_Missense_Mutation_p.T17M|TBXAS1_ENST00000425687.1_Intron|TBXAS1_ENST00000539806.1_Missense_Mutation_p.T18M|TBXAS1_ENST00000436047.2_Missense_Mutation_p.T18M|TBXAS1_ENST00000458722.1_Missense_Mutation_p.T17M|TBXAS1_ENST00000414508.2_Missense_Mutation_p.T18M|TBXAS1_ENST00000336425.5_Missense_Mutation_p.T17M|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000455353.1_Missense_Mutation_p.T17M|TBXAS1_ENST00000448866.1_Missense_Mutation_p.T17M|TBXAS1_ENST00000416849.2_Missense_Mutation_p.T18M	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	17					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CCCATGGTGACGGTGGCCCTG	0.572000													13	9					0	0	1	0	0
ZNF286B	729288	broad.mit.edu	37	17	18566140	18566140	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18566140G>A	ENST00000545289.1	-	5	929	c.679C>T	c.(679-681)Caa>Taa	p.Q227*		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	227					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						TTTGATTTTTGTTTCAAGCTT	0.343000													16	10					0	0	1	0	0
OR13A1	79290	broad.mit.edu	37	10	45799447	45799447	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:45799447C>T	ENST00000553795.1	-	4	732	c.424G>A	c.(424-426)Gca>Aca	p.A142T	OR13A1_ENST00000536058.1_Missense_Mutation_p.A142T|OR13A1_ENST00000374401.2_Missense_Mutation_p.A142T	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						CAGATGGCTGCGTACCGGTCA	0.627000													5	9					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4455264	4455264	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:4455264C>T	ENST00000254718.4	-	8	1240	c.934G>A	c.(934-936)Gcc>Acc	p.A312T	MYBBP1A_ENST00000381556.2_Missense_Mutation_p.A312T			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	312	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						AGGGGCAGGGCCGCGCCCAGC	0.637000													28	37					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205116859	205116859	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:205116859G>A	ENST00000367162.3	-	13	2647	c.2617C>T	c.(2617-2619)Cgt>Tgt	p.R873C	DSTYK_ENST00000367160.4_Missense_Mutation_p.R532C|DSTYK_ENST00000367161.3_Missense_Mutation_p.R828C	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	873	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						ACAGGAAGACGTTCTGGGCGA	0.552000													38	49					0	0	1	0	0
FADS1	3992	broad.mit.edu	37	11	61570338	61570338	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61570338C>T	ENST00000350997.7	-	11	1621	c.1389G>A	c.(1387-1389)ttG>ttA	p.L463L	FADS1_ENST00000460649.1_Silent_p.L108L|FADS1_ENST00000536991.1_Silent_p.L154L|FADS1_ENST00000433932.1_Silent_p.L322L|FADS2_ENST00000574708.1_Intron|FADS1_ENST00000542506.1_Silent_p.L322L	NM_013402.4	NP_037534.3	O60427	FADS1_HUMAN	fatty acid desaturase 1	406					cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)|endometrium(1)|lung(1)|urinary_tract(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GCTTGGCACACAAGGACTGCA	0.542000													10	37					0	0	1	0	0
RASSF8	11228	broad.mit.edu	37	12	26217739	26217739	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:26217739G>T	ENST00000405154.2	+	3	611	c.412G>T	c.(412-414)Gga>Tga	p.G138*	RASSF8_ENST00000381352.3_Nonsense_Mutation_p.G138*|RASSF8_ENST00000542865.1_Nonsense_Mutation_p.G138*|RASSF8_ENST00000541490.1_Nonsense_Mutation_p.G138*|RASSF8_ENST00000282884.9_Nonsense_Mutation_p.G138*	NM_001164748.1	NP_001158220.1	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	138					signal transduction					cervix(2)|endometrium(1)|large_intestine(6)|lung(15)|urinary_tract(1)	25	Colorectal(261;0.0847)					AGGTGCCAAAGGATTAATGGA	0.413000													35	64					1.30293e-26	1.45635e-26	1	1	0
KISS1	3814	broad.mit.edu	37	1	204161932	204161932	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:204161932C>T	ENST00000367194.4	-	2	221	c.73G>A	c.(73-75)Gtg>Atg	p.V25M		NM_002256.3	NP_002247.3	Q15726	KISS1_HUMAN	KiSS-1 metastasis-suppressor	25					cytoskeleton organization	extracellular region	protein binding			large_intestine(1)|lung(1)|ovary(1)	3	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)	Breast(1374;9.42e-05)	KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.069)|Kidney(21;0.0934)|Epithelial(59;0.239)	Colorectal(1306;0.0129)		ACAGAGGCCACCTTTTCTAAT	0.507000													6	7					0	0	1	0	0
AK1	203	broad.mit.edu	37	9	130634180	130634180	+	Silent	SNP	G	G	A	rs73669436	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130634180G>A	ENST00000373176.1	-	5	398	c.246C>T	c.(244-246)gcC>gcT	p.A82A	AK1_ENST00000373156.1_Silent_p.A82A|RP11-203J24.9_ENST00000476274.2_RNA|AK1_ENST00000223836.10_Silent_p.A98A	NM_000476.2	NP_000467.1	P00568	KAD1_HUMAN	adenylate kinase 1	82					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding			endometrium(1)|prostate(1)	2						TATTGACTTTGGCCACCATGG	0.587000													6	15					0	0	1	0	0
HACE1	57531	broad.mit.edu	37	6	105231961	105231961	+	Splice_Site	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:105231961C>A	ENST00000262903.4	-	14	1842	c.1566_splice	c.e14+1	p.Q522_splice	HACE1_ENST00000369125.2_Splice_Site_p.Q522_splice	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	522					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		AAATTTCTACCTGTGCTTTTA	0.269000													7	19					0.000157383	0.000161063	1	1	0
COL11A1	1301	broad.mit.edu	37	1	103428213	103428213	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:103428213G>A	ENST00000358392.2	-	39	3373	c.3056C>T	c.(3055-3057)gCa>gTa	p.A1019V	COL11A1_ENST00000353414.4_Missense_Mutation_p.A968V|COL11A1_ENST00000370096.3_Missense_Mutation_p.A1007V|COL11A1_ENST00000512756.1_Missense_Mutation_p.A891V	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1007	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTGTACCTTTGCACCTTCTTT	0.463000													15	20					0	0	1	0	0
HGS	9146	broad.mit.edu	37	17	79657240	79657240	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:79657240C>T	ENST00000329138.4	+	6	579	c.444C>T	c.(442-444)agC>agT	p.S148S		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	148					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			TCAAAGAGAGCGATGCCATGT	0.622000													25	28					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62125289	62125289	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62125289G>A	ENST00000433197.2	-	19	2553	c.2458C>T	c.(2458-2460)Cgc>Tgc	p.R820C		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	820	Protein kinase.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						GCTGAGGGGCGTTTCTGAGGA	0.468000													10	25					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75982327	75982327	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75982327A>G	ENST00000308508.5	-	3	1171	c.1079T>C	c.(1078-1080)gTc>gCc	p.V360A		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	360	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						CTGGCCATTGACACTGAGGTC	0.637000													6	7					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319298	21319298	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:21319298T>C	ENST00000583088.1	+	3	1539	c.644T>C	c.(643-645)gTg>gCg	p.V215A	KCNJ12_ENST00000331718.5_Missense_Mutation_p.V215A	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		ATGTGGCGTGTGGGTAACCTG	0.652000										Prostate(3;0.18)			6	32					0	0	1	0	0
LRRC37A2	474170	broad.mit.edu	37	17	44626527	44626527	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:44626527G>T	ENST00000576629.1	+	10	4517	c.4022G>T	c.(4021-4023)aGg>aTg	p.R1341M	ARL17A_ENST00000329240.4_Intron|ARL17A_ENST00000573185.1_Intron|ARL17A_ENST00000337845.7_Intron|ARL17A_ENST00000445552.2_Intron|LRRC37A2_ENST00000333412.3_Missense_Mutation_p.R1341M			A6NM11	L37A2_HUMAN	leucine rich repeat containing 37, member A2	1341						integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|pancreas(4)|prostate(2)	15		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		CTCGCAAACAGGCTTCCATTC	0.463000													26	103					6.05902e-23	6.74593e-23	1	1	0
ADCK3	56997	broad.mit.edu	37	1	227149094	227149094	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:227149094C>T	ENST00000366779.1	+	7	2779	c.8C>T	c.(7-9)gCc>gTc	p.A3V	ADCK3_ENST00000478406.1_Intron|ADCK3_ENST00000366775.1_5'UTR|ADCK3_ENST00000366776.1_Missense_Mutation_p.A3V|ADCK3_ENST00000458507.2_Intron|ADCK3_ENST00000366777.3_Missense_Mutation_p.A3V|ADCK3_ENST00000366778.1_Intron			Q8NI60	ADCK3_HUMAN	aarF domain containing kinase 3	3					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(2)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	9						AGGATGGCTGCCATATTGGGA	0.607000													9	58					0	0	1	0	0
HSPB8	26353	broad.mit.edu	37	12	119617249	119617249	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:119617249G>A	ENST00000281938.2	+	1	803	c.132G>A	c.(130-132)ttG>ttA	p.L44L		NM_014365.2	NP_055180.1	Q9UJY1	HSPB8_HUMAN	heat shock 22kDa protein 8	44					cell death|response to heat	cytoplasm|nucleus	identical protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	14	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGACGACTTGACAGCCTCTT	0.682000													42	76					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16339794	16339794	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:16339794T>C	ENST00000400202.1	-	3	1432	c.720A>G	c.(718-720)ttA>ttG	p.L240L	NRIP1_ENST00000400199.1_Silent_p.L240L|NRIP1_ENST00000318948.4_Silent_p.L240L			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	240	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		CAACAGCCTGTAATCTTGCAG	0.458000													62	22					0	0	1	0	0
OBP2B	29989	broad.mit.edu	37	9	136083896	136083896	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136083896C>A	ENST00000372034.3	-	2	207	c.166G>T	c.(166-168)Gcc>Tcc	p.A56S	OBP2B_ENST00000461961.1_Intron|OBP2B_ENST00000372032.2_Intron	NM_014581.2	NP_055396.1	Q9NPH6	OBP2B_HUMAN	odorant binding protein 2B	56					chemosensory behavior|sensory perception of smell	extracellular region	odorant binding|transporter activity			central_nervous_system(2)|large_intestine(1)|lung(3)|skin(1)	7				OV - Ovarian serous cystadenocarcinoma(145;3.41e-06)|Epithelial(140;1.88e-05)		CCGCCCAGGGCTGTCACCTTC	0.617000													9	7					2.17888e-05	2.24846e-05	1	1	0
CTDSPL	10217	broad.mit.edu	37	3	38022319	38022319	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:38022319C>T	ENST00000443503.2	+	7	999	c.759C>T	c.(757-759)gaC>gaT	p.D253D	CTDSPL_ENST00000310189.3_3'UTR|CTDSPL_ENST00000273179.5_Silent_p.D264D	NM_005808.2	NP_005799.2	O15194	CTDSL_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	264	FCP1 homology.					nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|large_intestine(4)|skin(1)	8		Melanoma(1037;0.0122)		KIRC - Kidney renal clear cell carcinoma(284;0.0729)|Kidney(284;0.0902)		GCCGGGAGGACGACGTGTACA	0.622000													10	17					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67577103	67577103	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67577103G>A	ENST00000540839.3	+	14	2694	c.2474G>A	c.(2473-2475)cGt>cAt	p.R825H	FAM65A_ENST00000428437.2_Missense_Mutation_p.R819H|FAM65A_ENST00000042381.4_Missense_Mutation_p.R805H|FAM65A_ENST00000379312.3_Missense_Mutation_p.R809H|FAM65A_ENST00000422602.2_Missense_Mutation_p.R825H			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	809						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		GATGACTACCGTGGCCAGTTT	0.657000													5	6					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179542933	179542933	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179542933G>A	ENST00000589042.1	-	145	34137	c.33913C>T	c.(33913-33915)Cca>Tca	p.P11305S	TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.P10988S|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.P10061S|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10988	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCACCTCTGGCACTTTAAAG	0.338000													28	51					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76948992	76948992	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:76948992C>T	ENST00000380887.2	+	5	749	c.677C>T	c.(676-678)gCc>gTc	p.A226V	ESRRB_ENST00000261532.7_Missense_Mutation_p.A226V|ESRRB_ENST00000509242.1_Missense_Mutation_p.A226V|ESRRB_ENST00000556177.1_Missense_Mutation_p.A226V			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	226						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		AAGCTCTATGCCATGCCTCCC	0.552000													10	31					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25600698	25600698	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:25600698C>T	ENST00000329474.6	+	33	3644	c.3276C>T	c.(3274-3276)ccC>ccT	p.P1092P		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1092					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						CAGAAGAACCCTCCTCACCAA	0.498000													8	46					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145834753	145834753	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:145834753C>T	ENST00000296702.5	+	2	232	c.194C>T	c.(193-195)cCg>cTg	p.P65L	TCERG1_ENST00000394421.2_Missense_Mutation_p.P65L	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	65	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCACCACGGCCGCCCTTTGGA	0.597000													41	45					0	0	1	0	0
TMEM168	64418	broad.mit.edu	37	7	112412892	112412892	+	Missense_Mutation	SNP	G	G	A	rs150249344		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:112412892G>A	ENST00000312814.5	-	4	2050	c.1490C>T	c.(1489-1491)aCg>aTg	p.T497M	TMEM168_ENST00000454074.1_Missense_Mutation_p.T497M	NM_022484.4	NP_071929.3	Q9H0V1	TM168_HUMAN	transmembrane protein 168	497						integral to membrane|transport vesicle				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|stomach(1)	32						CAAAATATACGTATCATGTCT	0.438000													28	32					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3919745	3919745	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:3919745G>T	ENST00000381638.2	-	49	8141	c.8017C>A	c.(8017-8019)Ctc>Atc	p.L2673I		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2673							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CAGCCCTGGAGCACTTTCTGC	0.572000													17	17					1.67942e-08	1.77343e-08	1	1	0
SLC12A4	6560	broad.mit.edu	37	16	67986250	67986250	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67986250G>A	ENST00000422611.2	-	6	799	c.760C>T	c.(760-762)Cgt>Tgt	p.R254C	SLC12A4_ENST00000537830.2_Missense_Mutation_p.R246C|SLC12A4_ENST00000576616.1_Missense_Mutation_p.R252C|SLC12A4_ENST00000316341.3_Missense_Mutation_p.R252C|SLC12A4_ENST00000572037.1_Missense_Mutation_p.R204C|SLC12A4_ENST00000338335.3_Missense_Mutation_p.R252C|SLC12A4_ENST00000572010.1_5'UTR|SLC12A4_ENST00000541864.2_Missense_Mutation_p.R221C	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	252					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCATACACACGCATATTGTTC	0.483000													19	33					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7330459	7330459	+	Silent	SNP	T	T	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:7330459T>G	ENST00000333870.3	+	3	1223	c.1149T>G	c.(1147-1149)cgT>cgG	p.R383R	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_3'UTR	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	383						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				AGGTGCGGCGTCGGGCAGCTG	0.677000													11	8					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103143553	103143553	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:103143553C>T	ENST00000428762.1	-	52	8558	c.8399G>A	c.(8398-8400)tGc>tAc	p.C2800Y	RELN_ENST00000343529.5_Missense_Mutation_p.C2800Y|RELN_ENST00000424685.2_Missense_Mutation_p.C2800Y|CTB-107G13.1_ENST00000422488.1_RNA	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2800					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACTTCCAGAGCATTTTGGGTC	0.433000													7	55					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1271758	1271758	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:1271758G>A	ENST00000447027.1	+	31	13715	c.13657G>A	c.(13657-13659)Gcc>Acc	p.A4553T	MUC5B_ENST00000529681.1_Missense_Mutation_p.A4550T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4550	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CATGTCCACAGCCACACCCTC	0.657000													43	62					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	844870	844870	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:844870G>A	ENST00000314167.4	-	26	3621	c.3511C>T	c.(3511-3513)Caa>Taa	p.Q1171*	GAK_ENST00000511163.1_Nonsense_Mutation_p.Q1092*|GAK_ENST00000509566.1_5'UTR	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	1171					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		TTTGGCTTTTGAGCTAGAAAA	0.468000													30	46					0	0	1	0	0
SMURF2	64750	broad.mit.edu	37	17	62582227	62582227	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62582227T>C	ENST00000262435.9	-	6	649	c.462A>G	c.(460-462)ttA>ttG	p.L154L	SMURF2_ENST00000578200.1_Intron	NM_022739.3	NP_073576.1	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	154					BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(4)	22	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			CGTTATCAAATAAACGACTGC	0.338000													37	69					0	0	1	0	0
MEX3A	92312	broad.mit.edu	37	1	156046389	156046389	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156046389C>T	ENST00000532414.2	-	2	1538	c.1539G>A	c.(1537-1539)acG>acA	p.T513T		NM_001093725.1	NP_001087194.1	A1L020	MEX3A_HUMAN	mex-3 RNA binding family member A	513						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	Hepatocellular(266;0.158)|all_neural(408;0.195)					GGATGGCTTGCGTGGCTGTGA	0.602000													12	23					0	0	1	0	0
RTN4	57142	broad.mit.edu	37	2	55277340	55277340	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:55277340C>T	ENST00000337526.6	-	1	340	c.97G>A	c.(97-99)Gac>Aac	p.D33N	RTN4_ENST00000394611.2_Intron|RTN4_ENST00000404909.1_Intron|RTN4_ENST00000317610.7_Missense_Mutation_p.D33N|RTN4_ENST00000354474.6_Missense_Mutation_p.D33N|RTN4_ENST00000357732.4_Missense_Mutation_p.D33N|RTN4_ENST00000402434.2_Missense_Mutation_p.D5N	NM_020532.4	NP_065393.1	Q9NQC3	RTN4_HUMAN	reticulon 4	33	Poly-Glu.				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						tcctcctcgtcctcGGGCTCC	0.667000													3	2					0	0	1	0	0
PRKCZ	5590	broad.mit.edu	37	1	2116391	2116391	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:2116391G>A	ENST00000400921.2	+	15	1856	c.1173G>A	c.(1171-1173)gaG>gaA	p.E391E	PRKCZ_ENST00000479263.1_3'UTR|PRKCZ_ENST00000400920.1_Silent_p.E391E|C1orf86_ENST00000400919.3_3'UTR	NM_001033581.1	NP_001028753.1	Q05513	KPCZ_HUMAN	protein kinase C, zeta	574	Protein kinase.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		ACCAGTCAGAGTTCGAAGGCT	0.577000													9	4					0	0	1	0	0
GDF3	9573	broad.mit.edu	37	12	7842906	7842906	+	Silent	SNP	G	G	T	rs145601141		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:7842906G>T	ENST00000329913.3	-	2	710	c.663C>A	c.(661-663)acC>acA	p.T221T		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	221					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						GTCTGGCACAGGTGTCTTCAG	0.507000													14	43					1.5842e-08	1.67426e-08	1	1	0
RBM14	10432	broad.mit.edu	37	11	66392897	66392897	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:66392897G>A	ENST00000310137.4	+	2	1689	c.1550G>A	c.(1549-1551)cGc>cAc	p.R517H	RBM14-RBM4_ENST00000412278.2_Intron|RBM14_ENST00000409738.4_Intron|RBM14-RBM4_ENST00000500635.2_Intron|RBM4_ENST00000514361.3_Intron|RBM14_ENST00000393979.3_Intron|RBM4_ENST00000503028.2_Intron	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	517	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						GCTCCTTACCGCACTCAGTCA	0.657000													14	30					0	0	1	0	0
NKG7	4818	broad.mit.edu	37	19	51875455	51875455	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:51875455G>A	ENST00000595217.1	-	2	324	c.157_splice	c.e2-1	p.G53_splice	NKG7_ENST00000221978.5_Silent_p.G88G|NKG7_ENST00000600427.1_Splice_Site_p.G53_splice			Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	88						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GCGGGCCGTGGCCTGGGGGGA	0.622000													30	36					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58121147	58121147	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:58121147A>T	ENST00000257897.3	-	16	2093	c.2008T>A	c.(2008-2010)Tcg>Acg	p.S670T	AGAP2_ENST00000547588.1_Missense_Mutation_p.S1026T|AGAP2-AS1_ENST00000542466.2_Silent_p.R124R	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	1026					axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						GCTTACCGCGAAGAGTCCCGC	0.672000													5	10					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124743643	124743643	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:124743643G>A	ENST00000397801.1	+	11	1861	c.1669G>A	c.(1669-1671)Ggg>Agg	p.G557R	ROBO3_ENST00000538940.1_Missense_Mutation_p.G535R	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	557	Fibronectin type-III 1.				axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TTCCCCTCCGGGGGCTCCCTC	0.527000													10	11					0	0	1	0	0
GNG2	54331	broad.mit.edu	37	14	52433395	52433395	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:52433395C>T	ENST00000335281.4	+	3	612	c.206C>T	c.(205-207)gCc>gTc	p.A69V	GNG2_ENST00000556766.1_Missense_Mutation_p.A69V|GNG2_ENST00000555472.1_Missense_Mutation_p.A69V|GNG2_ENST00000554736.1_Missense_Mutation_p.A69V|GNG2_ENST00000556752.1_Missense_Mutation_p.A69V|GNG2_ENST00000553299.1_3'UTR|GNG2_ENST00000557376.1_Missense_Mutation_p.A108V|GNG2_ENST00000553432.1_Missense_Mutation_p.A100V	NM_001243774.1	NP_001230703.1	P59768	GBG2_HUMAN	guanine nucleotide binding protein (G protein), gamma 2	69					cellular response to glucagon stimulus|energy reserve metabolic process|platelet activation|synaptic transmission	heterotrimeric G-protein complex	protein binding|signal transducer activity			lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	5	all_epithelial(31;0.0659)|Breast(41;0.0684)				Halothane(DB01159)	TTTTTCTGTGCCATCCTTTAA	0.512000													30	62					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56417320	56417320	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:56417320T>C	ENST00000370754.5	-	61	16176	c.16177A>G	c.(16177-16179)Act>Gct	p.T5393A	DST_ENST00000370769.4_Missense_Mutation_p.T5215A|DST_ENST00000370788.2_Missense_Mutation_p.T3127A|DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Missense_Mutation_p.T2801A|DST_ENST00000361203.3_Missense_Mutation_p.T5213A|DST_ENST00000421834.2_Missense_Mutation_p.T3127A|DST_ENST00000446842.2_Missense_Mutation_p.T4889A			Q03001	DYST_HUMAN	dystonin	5213					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GCTTTTATAGTTTCCTTTTGC	0.418000													11	32					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127796803	127796803	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:127796803G>A	ENST00000556132.1	-	6	3232	c.2368C>T	c.(2368-2370)Cgc>Tgc	p.R790C	SOGA3_ENST00000481848.2_Missense_Mutation_p.R790C|SOGA3_ENST00000368268.2_Missense_Mutation_p.R790C|SOGA3_ENST00000525778.1_Missense_Mutation_p.R790C|SOGA3_ENST00000465909.2_Missense_Mutation_p.R790C|SOGA3_ENST00000474293.2_5'UTR	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	790						integral to membrane		p.R790C(1)									GTGAGGCAGCGGATGTTGCGC	0.701000													15	28					0	0	1	0	0
DDX23	9416	broad.mit.edu	37	12	49226221	49226221	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:49226221A>G	ENST00000308025.3	-	14	2018	c.1939T>C	c.(1939-1941)Tca>Cca	p.S647P		NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	647						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						TCTGACTCTGACATGAGGAAG	0.557000													25	46					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	372675	372675	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:372675C>T	ENST00000342640.4	-	5	633	c.591G>A	c.(589-591)ctG>ctA	p.L197L	THEG_ENST00000346878.2_Silent_p.L173L	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	197					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGCCGAGACAGTTCCTCCA	0.562000													7	53					0	0	1	0	0
KDM3A	55818	broad.mit.edu	37	2	86716755	86716755	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:86716755G>A	ENST00000409556.1	+	24	3911	c.3546G>A	c.(3544-3546)acG>acA	p.T1182T	KDM3A_ENST00000409064.1_Silent_p.T1182T|KDM3A_ENST00000312912.5_Silent_p.T1182T|KDM3A_ENST00000542128.1_Silent_p.T1130T			Q9Y4C1	KDM3A_HUMAN	lysine (K)-specific demethylase 3A	1182	JmjC.				androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						CAAAGGACACGGAGAAGATAA	0.413000													19	67					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134004775	134004775	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:134004775G>A	ENST00000359428.5	+	4	647	c.503G>A	c.(502-504)tGt>tAt	p.C168Y	NUP214_ENST00000451030.1_Missense_Mutation_p.C168Y|NUP214_ENST00000411637.2_Missense_Mutation_p.C168Y			P35658	NU214_HUMAN	nucleoporin 214kDa	168					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GTGGCAGTTTGTCTGGCTGAT	0.468000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								32	58					0	0	1	0	0
SNIP1	79753	broad.mit.edu	37	1	38005759	38005759	+	Splice_Site	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:38005759G>A	ENST00000296215.6	-	3	997	c.926_splice	c.e3+1	p.R309_splice		NM_024700.3	NP_078976.2	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein 1	309	FHA.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			breast(2)|cervix(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	25		Myeloproliferative disorder(586;0.0393)				GTTACTTACCGATATTGAAAG	0.428000													5	98					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75893364	75893364	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:75893364G>A	ENST00000322507.8	-	10	1602	c.1293C>T	c.(1291-1293)tgC>tgT	p.C431C	COL12A1_ENST00000483888.2_Silent_p.C431C|COL12A1_ENST00000416123.2_Silent_p.C431C|COL12A1_ENST00000345356.6_Intron	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	431					cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CACCACGTGAGCATTCTGTAA	0.313000													28	51					0	0	1	0	0
EME1	146956	broad.mit.edu	37	17	48456920	48456920	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:48456920G>A	ENST00000393271.2	+	7	1459	c.1377G>A	c.(1375-1377)gcG>gcA	p.A459A	EME1_ENST00000338165.4_Silent_p.A446A|EME1_ENST00000511648.2_Silent_p.A459A	NM_001166131.1	NP_001159603.1	Q96AY2	EME1_HUMAN	essential meiotic structure-specific endonuclease 1	446					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding			endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	19	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			TGGCTGAGGCGCCCTTCAAGT	0.547000								Direct reversal of damage;Homologous recombination					4	8					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32836467	32836467	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:32836467C>T	ENST00000380250.3	+	53	8130	c.7634C>T	c.(7633-7635)cCc>cTc	p.P2545L		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2545					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACTCTCTCCCCCTCTGAAGAG	0.423000													18	22					0	0	1	0	0
ZNF862	643641	broad.mit.edu	37	7	149558856	149558856	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:149558856C>T	ENST00000223210.4	+	7	2852	c.2607C>T	c.(2605-2607)aaC>aaT	p.N869N		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	869					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						CAGAGGTGAACGCCACGCTGG	0.587000													9	5					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48389522	48389522	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:48389522G>A	ENST00000380518.3	-	10	843	c.679C>T	c.(679-681)Cct>Tct	p.P227S	COL2A1_ENST00000337299.6_Missense_Mutation_p.P158S	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	227	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	ggttcaccaggATTGCCTTGA	0.502000													12	12					0	0	1	0	0
RPLP0P2	0	broad.mit.edu	37	11	61405066	61405066	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:61405066G>A	ENST00000496593.1	+	0	1670					NR_002775.2																						AGGAAGAGTCGGAGGGAGGAG	0.522000													18	19					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115987859	115987859	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:115987859T>C	ENST00000251864.2	+	25	3666	c.3513T>C	c.(3511-3513)ttT>ttC	p.F1171F	TDRD1_ENST00000422662.1_Silent_p.F699F|TDRD1_ENST00000369280.1_Silent_p.F1095F|TDRD1_ENST00000369281.2_Silent_p.F1057F|TDRD1_ENST00000369282.1_Silent_p.F1095F	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	1171					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		AAAATAAATTTATTGAAATGA	0.303000													6	11					0	0	1	0	0
CRY2	1408	broad.mit.edu	37	11	45891993	45891993	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:45891993C>T	ENST00000443527.2	+	9	1544	c.1522C>T	c.(1522-1524)Cgg>Tgg	p.R508W	CRY2_ENST00000417225.2_Missense_Mutation_p.R426W	NM_021117.3	NP_066940.2	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like)	487					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(2)	15						GGACTACCCACGGCCCATCGT	0.527000													10	35					0	0	1	0	0
NDUFV3	4731	broad.mit.edu	37	21	44323568	44323568	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:44323568C>T	ENST00000354250.2	+	3	515	c.446C>T	c.(445-447)aCg>aTg	p.T149M	NDUFV3_ENST00000340344.3_Intron|NDUFV3_ENST00000460259.1_3'UTR	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	0					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	CGGAAAGTGACGTCGCCTTCG	0.488000													53	26					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136641200	136641200	+	Silent	SNP	C	C	T	rs150295787		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:136641200C>T	ENST00000371851.1	-	22	2263	c.1938G>A	c.(1936-1938)ccG>ccA	p.P646P	VAV2_ENST00000406606.3_Silent_p.P646P|VAV2_ENST00000371850.3_Silent_p.P656P			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	656	SH3 1.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GGCTGATGGGCGGCTGGTGGC	0.617000													21	26					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122394993	122394993	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:122394993G>T	ENST00000288912.4	+	11	2403	c.1549G>T	c.(1549-1551)Ggt>Tgt	p.G517C	WDR66_ENST00000397454.2_Missense_Mutation_p.G517C	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	517							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CATTGTCACAGGTGACATTAA	0.373000													20	44					6.44725e-10	6.8705e-10	1	1	0
XPO7	23039	broad.mit.edu	37	8	21860776	21860776	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:21860776A>G	ENST00000434536.1	+	26	3119	c.3017A>G	c.(3016-3018)aAc>aGc	p.N1006S	XPO7_ENST00000252512.9_Missense_Mutation_p.N997S|XPO7_ENST00000433566.4_Missense_Mutation_p.N998S			Q9UIA9	XPO7_HUMAN	exportin 7	997					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		GACTGTAGGAACCAGTGGTCT	0.478000													4	14					0	0	1	0	0
CENPC	1060	broad.mit.edu	37	4	68374560	68374560	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:68374560C>T	ENST00000273853.6	-	10	2126	c.1876G>A	c.(1876-1878)Gct>Act	p.A626T		NM_001812.2	NP_001803.2			centromere protein C																		TTCTTCTTAGCCAAGTCTGCC	0.353000													16	24					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227558	38227558	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:38227558C>A	ENST00000373048.4	-	3	368	c.369G>T	c.(367-369)aaG>aaT	p.K123N	EPHA10_ENST00000319637.6_Missense_Mutation_p.K123N|EPHA10_ENST00000427468.2_Missense_Mutation_p.K123N	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	123						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGAAGGTCTCCTTGCAGGTAC	0.662000													33	45					2.66277e-13	2.8908e-13	1	1	0
ZDHHC8	29801	broad.mit.edu	37	22	20132768	20132768	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:20132768A>G	ENST00000334554.7	+	11	2284	c.2143A>G	c.(2143-2145)Aag>Gag	p.K715E	ZDHHC8_ENST00000320602.7_Missense_Mutation_p.K623E|ZDHHC8_ENST00000405930.3_Intron	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	715						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding	p.K715*(1)		breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					CCCTCAGCTGAAGACTCCCCC	0.632000													72	111					0	0	1	0	0
CCDC24	149473	broad.mit.edu	37	1	44457979	44457979	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:44457979G>A	ENST00000372318.3	+	3	393	c.222G>A	c.(220-222)ccG>ccA	p.P74P	SLC6A9_ENST00000372307.3_Intron|CCDC24_ENST00000486064.1_3'UTR|SLC6A9_ENST00000372306.3_Intron	NM_152499.1	NP_689712.1	Q8N4L8	CCD24_HUMAN	coiled-coil domain containing 24	74										endometrium(3)|large_intestine(2)|lung(3)|stomach(1)	9	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TGGCACCACCGCCTCTCCTAA	0.642000													38	62					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46628488	46628488	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:46628488G>A	ENST00000470495.1	-	2	1951	c.504C>T	c.(502-504)agC>agT	p.S168S	HOXB3_ENST00000490677.1_Silent_p.S34S|HOXB-AS1_ENST00000435312.1_RNA|HOXB3_ENST00000498678.1_Silent_p.S168S|HOXB3_ENST00000311626.4_Silent_p.S168S|HOXB3_ENST00000476342.1_Silent_p.S168S|HOXB3_ENST00000489475.1_Silent_p.S95S|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Silent_p.S36S|HOXB3_ENST00000472863.1_Silent_p.S95S|HOXB-AS1_ENST00000502764.2_RNA|HOXB3_ENST00000485909.2_Silent_p.S36S			P14651	HXB3_HUMAN	homeobox B3	168	Gly-rich.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						caccgcccccgctgccaccac	0.751000													9	7					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	100219106	100219106	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:100219106C>T	ENST00000547776.2	-	2	195	c.196G>A	c.(196-198)Gca>Aca	p.A66T	ANKS1B_ENST00000547010.1_Intron|ANKS1B_ENST00000329257.7_Missense_Mutation_p.A66T	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	66						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TTTAAGGCTGCGTGGTGTAAA	0.438000													9	16					0	0	1	0	0
KLK12	43849	broad.mit.edu	37	19	51535246	51535246	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:51535246G>A	ENST00000525263.1	-	3	462	c.343C>T	c.(343-345)Cgc>Tgc	p.R115C	KLK12_ENST00000529888.1_Intron|CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000319590.4_Missense_Mutation_p.R115C|KLK12_ENST00000250351.4_Missense_Mutation_p.R115C|KLK12_ENST00000250352.11_Intron			Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	115	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		ACGGGCAGGCGCAGCCGCAGC	0.682000													11	11					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66242775	66242775	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:66242775G>A	ENST00000273854.3	-	9	2397	c.1797C>T	c.(1795-1797)tgC>tgT	p.C599C	EPHA5_ENST00000511294.1_Silent_p.C600C|EPHA5_ENST00000354839.4_Intron|EPHA5_ENST00000432638.2_Silent_p.C436C	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	599					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						AGCCACATTCGCAGCAACTGA	0.473000										TSP Lung(17;0.13)			3	5					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53855127	53855127	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53855127G>A	ENST00000458035.1	+	4	1316	c.1199G>A	c.(1198-1200)cGc>cAc	p.R400H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R400H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TCCCTTACACGCCATCGTAGA	0.403000													33	48					0	0	1	0	0
LETMD1	25875	broad.mit.edu	37	12	51450273	51450273	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:51450273G>T	ENST00000418425.2	+	7	961	c.942G>T	c.(940-942)caG>caT	p.Q314H	LETMD1_ENST00000552739.1_Missense_Mutation_p.Q184H|LETMD1_ENST00000380123.2_3'UTR|LETMD1_ENST00000550929.1_Missense_Mutation_p.Q245H|LETMD1_ENST00000548516.1_3'UTR|LETMD1_ENST00000547008.1_Missense_Mutation_p.Q177H|LETMD1_ENST00000262055.4_Missense_Mutation_p.Q301H	NM_001243689.1	NP_001230618.1	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1	301	LETM1.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(3)	16						TGACTGCTCAGGAAGTAAAAT	0.502000													5	68					0.014758	0.0148771	1	1	0
BCAT2	587	broad.mit.edu	37	19	49303237	49303237	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:49303237C>T	ENST00000402551.1	-	6	1032		c.e6+1		BCAT2_ENST00000598162.1_Splice_Site|BCAT2_ENST00000597011.1_Splice_Site|BCAT2_ENST00000545387.2_Splice_Site|BCAT2_ENST00000599246.1_Splice_Site|BCAT2_ENST00000316273.6_Splice_Site			O15382	BCAT2_HUMAN	branched chain amino-acid transaminase 2, mitochondrial							mitochondrial matrix	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	12		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.000366)|Epithelial(262;0.0195)|GBM - Glioblastoma multiforme(486;0.0224)	L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|Pyridoxal Phosphate(DB00114)	GTTGGGCCCACCTCGTTCCCA	0.682000													7	19					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104206284	104206284	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:104206284G>A	ENST00000202556.9	-	12	2751	c.2469C>T	c.(2467-2469)aaC>aaT	p.N823N	PPP1R13B_ENST00000555391.1_5'UTR|PPP1R13B_ENST00000423488.2_Silent_p.N242N	NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	823	Pro-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				CCGTGGCCACGTTGTTGTTAT	0.602000													10	18					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67142747	67142747	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:67142747C>T	ENST00000371037.4	+	13	784	c.707C>T	c.(706-708)tCg>tTg	p.S236L	SGIP1_ENST00000371035.3_Missense_Mutation_p.S193L|SGIP1_ENST00000371036.3_Missense_Mutation_p.S203L|SGIP1_ENST00000371039.1_Missense_Mutation_p.S204L|SGIP1_ENST00000237247.6_Missense_Mutation_p.S240L|SGIP1_ENST00000468286.1_3'UTR	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	236	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						AGCATGGAGTCGCCAAAGTTA	0.403000													30	48					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891971	18891971	+	Nonsense_Mutation	SNP	C	C	T	rs15547		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:18891971C>T	ENST00000317658.3	+	1	927	c.769C>T	c.(769-771)Cga>Tga	p.R257*		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	257					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				AAAAATTCTACGAAGGGATCT	0.408000													17	36					0	0	1	0	0
ARIH1	25820	broad.mit.edu	37	15	72855772	72855772	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:72855772G>A	ENST00000379887.4	+	7	1156	c.842G>A	c.(841-843)tGc>tAc	p.C281Y		NM_005744.3	NP_005735.2	Q9Y4X5	ARI1_HUMAN	ariadne RBR E3 ubiquitin protein ligase 1	281					ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	14						GCCCCAGATTGCCACCATGTT	0.418000													42	51					0	0	1	0	0
WDFY1	57590	broad.mit.edu	37	2	224746674	224746674	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:224746674G>A	ENST00000233055.4	-	10	1151	c.1049C>T	c.(1048-1050)tCc>tTc	p.S350F		NM_020830.3	NP_065881.1	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	350						cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(6)|prostate(2)	18		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		ATCTTTGATGGAGTCGTAACA	0.463000													34	142					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52509599	52509599	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:52509599G>A	ENST00000216286.5	-	6	1479	c.1480C>T	c.(1480-1482)Caa>Taa	p.Q494*	NID2_ENST00000541773.1_Nonsense_Mutation_p.Q441*	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	494	EGF-like 1.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CGGGAGCATTGTCTGTGGTTG	0.458000													17	44					0	0	1	0	0
TAF7L	54457	broad.mit.edu	37	X	100538563	100538563	+	Missense_Mutation	SNP	G	G	A	rs145455495		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:100538563G>A	ENST00000372907.3	-	4	423	c.412C>T	c.(412-414)Cgc>Tgc	p.R138C	TAF7L_ENST00000356784.1_Missense_Mutation_p.R52C|TAF7L_ENST00000324762.6_Missense_Mutation_p.R52C|TAF7L_ENST00000372905.2_Missense_Mutation_p.R52C	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	138					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						ACTGCATGGCGCCCATCAGCT	0.398000													4	109					0	0	1	0	0
CSAD	51380	broad.mit.edu	37	12	53553931	53553931	+	Missense_Mutation	SNP	C	C	T	rs34792176		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:53553931C>T	ENST00000267085.4	-	14	1453	c.1220G>A	c.(1219-1221)cGc>cAc	p.R407H	CSAD_ENST00000379843.3_Missense_Mutation_p.R233H|RP11-1136G11.8_ENST00000550908.1_lincRNA|CSAD_ENST00000379846.1_Missense_Mutation_p.R233H|CSAD_ENST00000444623.1_Missense_Mutation_p.R380H|CSAD_ENST00000453446.2_Missense_Mutation_p.R380H	NM_001244706.1|NM_015989.4	NP_001231635.1|NP_057073.4	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	380					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(4)	14					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CTGGTCGATGCGCCGCTCCAG	0.657000											OREG0021859	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	14					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77617512	77617512	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:77617512A>T	ENST00000461745.1	+	13	2798	c.1898A>T	c.(1897-1899)gAg>gTg	p.E633V	ROBO2_ENST00000332191.8_Missense_Mutation_p.E633V|ROBO2_ENST00000487694.3_Missense_Mutation_p.E649V	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	633					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GTGCAGAAAGAGCTAGGAGAT	0.443000													15	25					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101763627	101763627	+	Silent	SNP	C	C	T	rs139074123		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:101763627C>T	ENST00000261637.4	+	49	6687	c.6513C>T	c.(6511-6513)gcC>gcT	p.A2171A		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	2171					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						AGCTCGGGGCCGCCAGGGGCC	0.512000													28	65					0	0	1	0	0
SHD	56961	broad.mit.edu	37	19	4288329	4288329	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:4288329C>T	ENST00000543264.2	+	5	2269	c.806C>T	c.(805-807)aCc>aTc	p.T269I	SHD_ENST00000599689.1_Intron	NM_020209.3	NP_064594.3	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming protein D	269	SH2.									breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|stomach(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCAGTGAGACCAACCCCCAG	0.567000													6	27					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33201840	33201840	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:33201840G>A	ENST00000557354.1	+	10	3280	c.3181G>A	c.(3181-3183)Gtg>Atg	p.V1061M	AKAP6_ENST00000280979.4_Intron|AKAP6_ENST00000557272.1_Intron			Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	0					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TGTAGGTTATGTGTACATTTT	0.338000													22	39					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46661673	46661673	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:46661673T>C	ENST00000544460.1	+	1	6062	c.5808T>C	c.(5806-5808)tgT>tgC	p.C1936C	TDRD6_ENST00000316081.6_Silent_p.C1936C	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1936					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AATCCATGTGTACTGAGGACA	0.433000													19	60					0	0	1	0	0
NACC1	112939	broad.mit.edu	37	19	13249036	13249036	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:13249036C>T	ENST00000292431.4	+	6	1526	c.1400C>T	c.(1399-1401)gCc>gTc	p.A467V		NM_052876.3	NP_443108.1	Q96RE7	NACC1_HUMAN	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	467	BEN.				negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body				endometrium(3)|large_intestine(2)|lung(3)|skin(1)	9						TGCACCAACGCCCGCCGCGTC	0.612000													41	69					0	0	1	0	0
SLC6A6	6533	broad.mit.edu	37	3	14489255	14489255	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:14489255G>A	ENST00000454876.2	+	5	859	c.530G>A	c.(529-531)cGc>cAc	p.R177H	SLC6A6_ENST00000416216.2_Missense_Mutation_p.R177H|SLC6A6_ENST00000484191.1_3'UTR|SLC6A6_ENST00000360861.3_Missense_Mutation_p.R177H			P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 6	177					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)	28						GACACCATGCGCAAGAACAAG	0.557000													32	50					0	0	1	0	0
SMCR7L	0	broad.mit.edu	37	22	39910048	39910048	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:39910048G>A	ENST00000325301.2	+	6	1536	c.1112G>A	c.(1111-1113)tGc>tAc	p.C371Y	SMCR7L_ENST00000402881.1_Missense_Mutation_p.C371Y|SMCR7L_ENST00000404569.1_Missense_Mutation_p.C371Y	NM_019008.4	NP_061881.2	Q9NQG6	SMC7L_HUMAN		371						integral to membrane|mitochondrion				central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|liver(1)|lung(6)|ovary(1)|skin(1)	16	Melanoma(58;0.04)					AAGGCCATATGCAAGTCCACC	0.647000											OREG0026577	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	33					0	0	1	0	0
SLC9B2	133308	broad.mit.edu	37	4	103970157	103970157	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:103970157G>A	ENST00000394785.3	-	6	1237	c.606C>T	c.(604-606)ggC>ggT	p.G202G	SLC9B2_ENST00000362026.3_Silent_p.G202G|SLC9B2_ENST00000339611.4_Silent_p.G202G|SLC9B2_ENST00000503230.1_Silent_p.G145G|SLC9B2_ENST00000503103.1_Silent_p.G145G	NM_178833.4	NP_849155.2	Q86UD5	NHDC2_HUMAN	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	202					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity	p.G202G(6)									TTACACAAACGCCCTTTAACT	0.448000													20	17					0	0	1	0	0
CD79B	0	broad.mit.edu	37	17	62007561	62007561	+	Silent	SNP	G	G	A	rs115494685	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:62007561G>A	ENST00000006750.3	-	3	395	c.303C>T	c.(301-303)aaC>aaT	p.N101N	CD79B_ENST00000392795.3_Silent_p.N102N|CD79B_ENST00000349817.2_Intron	NM_000626.2|NM_021602.2	NP_000617.1|NP_067613.1	P40259	CD79B_HUMAN	CD79b molecule, immunoglobulin-associated beta	101	Ig-like V-type.				cell surface receptor linked signaling pathway|immune response	Golgi apparatus|integral to plasma membrane|nucleus	transmembrane receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	15						CGAGAGATTCGTTCTGGGACT	0.567000			"""Mis, O"""		DLBCL								17	21					0	0	1	0	0
KRTAP9-4	85280	broad.mit.edu	37	17	39406184	39406184	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39406184G>A	ENST00000334109.2	+	1	246	c.212G>A	c.(211-213)tGc>tAc	p.C71Y		NM_033191.2	NP_149461.2	Q9BYQ2	KRA94_HUMAN	keratin associated protein 9-4	71	15 X 5 AA repeats of C-C-[RQVGE]-[SPTN]- [TASPF].					keratin filament		p.C71F(1)		breast(1)|large_intestine(1)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			ACCAGCTGCTGCCAGCCTTCC	0.627000													28	43					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177136781	177136781	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:177136781C>T	ENST00000296525.3	-	7	1073	c.960G>A	c.(958-960)acG>acA	p.T320T	ASB5_ENST00000512254.1_Silent_p.T267T	NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	320	SOCS box.				intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TCTTCAGTAACGTTGGCAGCT	0.363000													16	35					0	0	1	0	0
N4BP2	55728	broad.mit.edu	37	4	40123912	40123912	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:40123912C>A	ENST00000261435.6	+	9	4597	c.4181C>A	c.(4180-4182)cCt>cAt	p.P1394H		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	1394						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						TTATTTGGTCCTGTTGGTATT	0.388000													27	46					7.92952e-12	8.55149e-12	1	1	0
CEP350	9857	broad.mit.edu	37	1	179991872	179991872	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:179991872G>T	ENST00000367607.3	+	13	3693	c.3275G>T	c.(3274-3276)cGg>cTg	p.R1092L		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1092						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TCAACATCACGGCCTTTGAAT	0.393000													3	18					0.00024832	0.000253518	1	1	0
TVP23C-CDRT4	0	broad.mit.edu	37	17	15457128	15457128	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:15457128C>T	ENST00000522212.2	-	3	223	c.111G>A	c.(109-111)tcG>tcA	p.S37S	TVP23C_ENST00000225576.3_Silent_p.S37S|TVP23C_ENST00000438826.3_Silent_p.S37S|TVP23C_ENST00000428082.2_Silent_p.S37S|TVP23C_ENST00000519970.1_Intron|TVP23C_ENST00000518321.1_Silent_p.S37S|TVP23C_ENST00000584811.1_5'UTR	NM_001204478.1	NP_001191407.1																					AGTGGAAAAACGATGCTACTG	0.368000													49	80					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3140145	3140145	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:3140145G>A	ENST00000252463.2	-	5	1212	c.1125C>T	c.(1123-1125)ccC>ccT	p.P375P	ZSCAN10_ENST00000575108.1_Silent_p.P36P|ZSCAN10_ENST00000538082.2_Silent_p.P293P	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	375					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						ACAGGAAGGCGGGTTCGGAGG	0.721000													22	35					0	0	1	0	0
IL2RB	0	broad.mit.edu	37	22	37524280	37524280	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37524280G>A	ENST00000216223.5	-	10	1710	c.1512C>T	c.(1510-1512)ggC>ggT	p.G504G		NM_000878.3	NP_000869.1	P14784	IL2RB_HUMAN	interleukin 2 receptor, beta	504					interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(5)	23					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	CCTCCCTGGGGCCAGCGTCAG	0.662000													17	16					0	0	1	0	0
SLC37A4	2542	broad.mit.edu	37	11	118898389	118898389	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:118898389C>T	ENST00000545985.1	-	6	1330	c.574G>A	c.(574-576)Gct>Act	p.A192T	SLC37A4_ENST00000538950.1_Missense_Mutation_p.A119T|SLC37A4_ENST00000330775.7_Missense_Mutation_p.A191T|SLC37A4_ENST00000525102.1_5'UTR|SLC37A4_ENST00000357590.5_Missense_Mutation_p.A192T	NM_001164277.1|NM_001467.5	NP_001157749.1|NP_001458.1	O43826	G6PT1_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 4	192					glucose homeostasis|glucose metabolic process	endoplasmic reticulum membrane|integral to endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphate transmembrane transporter activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|prostate(1)	6	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		CCAACATCAGCAGGTTCATTG	0.607000													10	10					0	0	1	0	0
KRT7	3855	broad.mit.edu	37	12	52627342	52627342	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:52627342C>T	ENST00000331817.5	+	1	445	c.262C>T	c.(262-264)Cgc>Tgc	p.R88C		NM_005556.3	NP_005547.3	P08729	K2C7_HUMAN	keratin 7	88	Head.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(357;0.105)		CCAGCGGGTGCGCCAGGAGGA	0.677000													4	68					0	0	1	0	0
ADAM15	8751	broad.mit.edu	37	1	155026819	155026819	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155026819G>A	ENST00000356955.2	+	6	550	c.449G>A	c.(448-450)aGc>aAc	p.S150N	ADAM15_ENST00000368410.2_Intron|ADAM15_ENST00000271836.6_Missense_Mutation_p.S150N|ADAM15_ENST00000368413.1_Intron|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000531455.1_Missense_Mutation_p.S160N|ADAM15_ENST00000368412.3_Missense_Mutation_p.S150N|ADAM15_ENST00000360674.4_Missense_Mutation_p.S150N|ADAM15_ENST00000355956.2_Missense_Mutation_p.S150N|ADAM15_ENST00000359280.4_Missense_Mutation_p.S150N|ADAM15_ENST00000447332.3_Missense_Mutation_p.S134N|ADAM15_ENST00000449910.2_Missense_Mutation_p.S150N	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	150					angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CCAGAGAGAAGCTATACCCTG	0.532000													19	52					0	0	1	0	0
TNK2	10188	broad.mit.edu	37	3	195599151	195599151	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195599151C>T	ENST00000333602.6	-	10	2064	c.1447G>A	c.(1447-1449)Gac>Aac	p.D483N	TNK2_ENST00000316664.3_Missense_Mutation_p.D483N|TNK2_ENST00000381916.2_Missense_Mutation_p.D546N|TNK2_ENST00000428187.1_Missense_Mutation_p.D515N|TNK2_ENST00000392400.1_Missense_Mutation_p.D483N	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	483				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	ACTCACTCGTCAATCCTGTCC	0.662000													13	13					0	0	1	0	0
PHYHIP	9796	broad.mit.edu	37	8	22079190	22079190	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22079190C>T	ENST00000454243.2	-	5	1243	c.669G>A	c.(667-669)gcG>gcA	p.A223A	PHYHIP_ENST00000321613.3_Silent_p.A223A	NM_014759.3	NP_055574.3	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	223										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	10				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		AGTAGAAGTCCGCAAAGTAGA	0.662000													3	6					0	0	1	0	0
METTL22	79091	broad.mit.edu	37	16	8722915	8722915	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:8722915C>T	ENST00000381920.3	+	3	720	c.462C>T	c.(460-462)gaC>gaT	p.D154D	METTL22_ENST00000561758.1_Silent_p.D98D	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	154							methyltransferase activity			large_intestine(5)|lung(4)	9						AGGAAGAAGACGACGTCCTGG	0.542000													46	93					0	0	1	0	0
RHOT2	89941	broad.mit.edu	37	16	722291	722291	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:722291G>T	ENST00000315082.4	+	15	1347	c.1233G>T	c.(1231-1233)caG>caT	p.Q411H		NM_138769.2	NP_620124.1	Q8IXI1	MIRO2_HUMAN	ras homolog family member T2	411	Miro 2.				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|pancreas(2)|prostate(1)	13		Hepatocellular(780;0.0218)				AGAAGGGACAGACGCAGCGGA	0.652000													18	26					6.94344e-10	7.39541e-10	1	1	0
SLC6A17	388662	broad.mit.edu	37	1	110716609	110716609	+	Silent	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110716609G>T	ENST00000331565.4	+	4	944	c.459G>T	c.(457-459)gtG>gtT	p.V153V		NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	153					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		GTCTCTTTGTGGGGCTGTATT	0.587000													37	56					9.62906e-15	1.05217e-14	1	1	0
PDE10A	10846	broad.mit.edu	37	6	165801936	165801936	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:165801936C>A	ENST00000366882.1	-	18	1787	c.1633G>T	c.(1633-1635)Gga>Tga	p.G545*	PDE10A_ENST00000539869.2_Nonsense_Mutation_p.G555*|PDE10A_ENST00000354448.4_Nonsense_Mutation_p.G545*			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	545					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	ATCAGCAGTCCTTTGCGCTTT	0.473000													33	61					7.04047e-22	7.82589e-22	1	1	0
SFTPA2	729238	broad.mit.edu	37	10	81319187	81319187	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:81319187G>A	ENST00000372325.2	-	3	137	c.53C>T	c.(52-54)gCt>gTt	p.A18V	SFTPA2_ENST00000372327.5_Missense_Mutation_p.A18V	NM_001098668.2	NP_001092138.1	Q8IWL1	SFPA2_HUMAN	surfactant protein A2	18					cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	sugar binding			endometrium(1)|kidney(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TTCGCACGCAGCACCAGAGGC	0.642000									Pulmonary Fibrosis, Idiopathic				18	65					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57430850	57430850	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:57430850C>T	ENST00000442789.2	-	21	2368	c.2081G>A	c.(2080-2082)cGc>cAc	p.R694H	MYO1A_ENST00000300119.3_Missense_Mutation_p.R694H|MYO1A_ENST00000544473.1_Missense_Mutation_p.R532H	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	694					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						GAGTCTCAGGCGCCTCTGTTC	0.562000													23	44					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139913201	139913201	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139913201C>T	ENST00000265662.5	-	13	1936	c.1789G>A	c.(1789-1791)Gcc>Acc	p.A597T	ABCA2_ENST00000492260.1_5'UTR|ABCA2_ENST00000371605.3_Missense_Mutation_p.A596T|ABCA2_ENST00000341511.6_Missense_Mutation_p.A597T			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	596					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TCCTGGTAGGCCTGGTTGAGG	0.657000													16	26					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155630479	155630479	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155630479G>A	ENST00000368340.5	-	10	1684	c.1576C>T	c.(1576-1578)Cgt>Tgt	p.R526C	YY1AP1_ENST00000368339.5_Missense_Mutation_p.R546C|YY1AP1_ENST00000368330.2_Missense_Mutation_p.R408C|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000311573.5_Missense_Mutation_p.R377C|YY1AP1_ENST00000361831.5_Missense_Mutation_p.R397C|YY1AP1_ENST00000404643.1_Missense_Mutation_p.R388C|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000407221.1_Missense_Mutation_p.R377C|YY1AP1_ENST00000295566.4_Missense_Mutation_p.R454C|YY1AP1_ENST00000535662.1_Missense_Mutation_p.R254C|YY1AP1_ENST00000347088.5_Missense_Mutation_p.R408C|YY1AP1_ENST00000355499.4_Missense_Mutation_p.R408C|YY1AP1_ENST00000359205.5_Missense_Mutation_p.R397C	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					ACTGATGAACGCTTCTGTCTC	0.542000													33	55					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332444	70332444	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:70332444G>A	ENST00000338508.4	-	32	3956	c.3957C>T	c.(3955-3957)acC>acT	p.T1319T	SHANK2_ENST00000423696.2_Silent_p.T939T|SHANK2_ENST00000449833.2_Silent_p.T723T|SHANK2_ENST00000409161.1_Silent_p.T722T			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	939					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGGCGTCCACGGTGTGCACCA	0.602000													15	24					0	0	1	0	0
C14orf119	55017	broad.mit.edu	37	14	23566895	23566895	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:23566895C>T	ENST00000319074.4	+	2	884	c.28C>T	c.(28-30)Cca>Tca	p.P10S	C14orf119_ENST00000554203.1_Missense_Mutation_p.P10S	NM_017924.3	NP_060394.1	Q9NWQ9	CN119_HUMAN	chromosome 14 open reading frame 119	10										central_nervous_system(1)|endometrium(1)|lung(1)	3	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00649)		CTCTTCAATGCCACTATCCTT	0.443000													4	106					0	0	1	0	0
XKR3	150165	broad.mit.edu	37	22	17288731	17288731	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:17288731G>A	ENST00000331428.5	-	2	335	c.233C>T	c.(232-234)gCa>gTa	p.A78V		NM_175878.3	NP_787074.2	Q5GH77	XKR3_HUMAN	XK, Kell blood group complex subunit-related family, member 3	78						integral to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ATCCAAAATTGCCCCCACAAT	0.353000													31	39					0	0	1	0	0
GPR137C	283554	broad.mit.edu	37	14	53100612	53100612	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:53100612C>T	ENST00000321662.6	+	6	1060	c.1060C>T	c.(1060-1062)Cga>Tga	p.R354*		NM_001099652.1	NP_001093122.1	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	354						integral to membrane				NS(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	8	Breast(41;0.0716)					CAATCCAAGACGATATGATAG	0.388000													14	26					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	157041158	157041158	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:157041158G>A	ENST00000348165.5	+	19	2938	c.2578G>A	c.(2578-2580)Gcc>Acc	p.A860T		NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	860	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		TCACCACCTCGCCTCCCTAGA	0.507000													10	134					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70257825	70257825	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:70257825C>T	ENST00000310961.5	+	5	722	c.304C>T	c.(304-306)Ctc>Ttc	p.L102F	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Missense_Mutation_p.L97F|LRRC7_ENST00000370958.1_Missense_Mutation_p.L135F			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	97						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TCTTAAAGAACTCGACATCAG	0.308000													22	43					0	0	1	0	0
MLNR	2862	broad.mit.edu	37	13	49795147	49795147	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:49795147C>T	ENST00000398307.1	+	1	674	c.674C>T	c.(673-675)gCg>gTg	p.A225V	MLNR_ENST00000218721.1_Missense_Mutation_p.A225V			O43193	MTLR_HUMAN	motilin receptor	225					digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity			endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)	14		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		CCCGAGACCGCGGAGGCCGCG	0.751000													12	13					0	0	1	0	0
PCDHGB4	0	broad.mit.edu	37	5	140768945	140768945	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140768945G>A	ENST00000519479.1	+	1	1494	c.1494G>A	c.(1492-1494)gaG>gaA	p.E498E	PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAGCGGGAGCTGTCATCCT	0.617000													33	56					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29292061	29292061	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:29292061C>T	ENST00000266943.6	-	2	444	c.75G>A	c.(73-75)acG>acA	p.T25T	SLC46A3_ENST00000380814.4_Silent_p.T25T	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	25					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		AAACATATTGCGTTGTCAGTG	0.378000													31	52					0	0	1	0	0
WDR91	29062	broad.mit.edu	37	7	134889022	134889022	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:134889022G>A	ENST00000354475.4	-	6	920	c.889C>T	c.(889-891)Cag>Tag	p.Q297*	WDR91_ENST00000423565.1_Nonsense_Mutation_p.Q262*|WDR91_ENST00000485942.1_5'UTR|WDR91_ENST00000344400.5_Nonsense_Mutation_p.Q297*	NM_014149.3	NP_054868.3	A4D1P6	WDR91_HUMAN	WD repeat domain 91	297										breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						GTGCTTACCTGACCACCGAAG	0.577000													10	16					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240297	3240297	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:3240297G>A	ENST00000217939.6	-	5	3583	c.3429C>T	c.(3427-3429)agC>agT	p.S1143S		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1143						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAGGGTGAGTGCTCATGGTGG	0.532000													9	20					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28538078	28538078	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:28538078C>A	ENST00000261609.7	-	4	386	c.278G>T	c.(277-279)aGg>aTg	p.R93M		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	93					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.R93M(1)		NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TGACTTGGCCCTATATATAGG	0.413000													10	11					3.07112e-06	3.18879e-06	1	1	0
MATK	4145	broad.mit.edu	37	19	3784338	3784338	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3784338C>T	ENST00000310132.6	-	4	642	c.244G>A	c.(244-246)Gag>Aag	p.E82K	MATK_ENST00000395040.2_Missense_Mutation_p.E41K|MATK_ENST00000585778.1_Missense_Mutation_p.E82K|MATK_ENST00000395045.2_Missense_Mutation_p.E83K	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	82	SH3.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCTCACCTCGCAGGCCTCC	0.697000													6	3					0	0	1	0	0
EDF1	8721	broad.mit.edu	37	9	139757758	139757758	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:139757758C>T	ENST00000371648.4	-	3	280	c.273G>A	c.(271-273)acG>acA	p.T91T	EDF1_ENST00000371649.1_Silent_p.T91T|EDF1_ENST00000224073.1_Silent_p.T91T	NM_153200.1	NP_694880.1	O60869	EDF1_HUMAN	endothelial differentiation-related factor 1	91	HTH cro/C1-type.|Interaction with NR5A2, PPARG and NR1H3.|Interaction with TBP and NR5A1.				endothelial cell differentiation|multicellular organismal development|positive regulation of DNA binding|positive regulation of transcription, DNA-dependent|regulation of lipid metabolic process|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	calmodulin binding|protein binding|sequence-specific DNA binding|transcription coactivator activity			lung(1)	1	all_cancers(76;0.0841)|all_epithelial(76;0.217)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		GGTCCTTCTGCGTAAGCCCCT	0.662000													19	22					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65386062	65386062	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:65386062G>A	ENST00000355703.3	+	6	1768	c.1229G>A	c.(1228-1230)cGg>cAg	p.R410Q		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	410						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						GCCCCTCGACGGCCCCTGCTT	0.652000													8	8					0	0	1	0	0
NUGGC	389643	broad.mit.edu	37	8	27886836	27886836	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:27886836C>T	ENST00000413272.2	-	17	2243	c.2101G>A	c.(2101-2103)Ggc>Agc	p.G701S	NUGGC_ENST00000341513.6_Missense_Mutation_p.G701S	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		TCAAACATGCCCTCAGCCACC	0.557000													6	18					0	0	1	0	0
HEATR5A	25938	broad.mit.edu	37	14	31763122	31763122	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:31763122C>A	ENST00000543095.2	-	35	5992	c.5808G>T	c.(5806-5808)ctG>ctT	p.L1936L	RP11-596D21.1_ENST00000551799.1_RNA|HEATR5A_ENST00000439727.1_Silent_p.L1643L|HEATR5A_ENST00000389961.3_Silent_p.L1930L|HEATR5A_ENST00000439348.1_Silent_p.L1855L	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1930							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		CAACAGTAACCAGTGTTTCTA	0.363000													4	12					1	1	1	1	0
LRP8	7804	broad.mit.edu	37	1	53736988	53736988	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:53736988C>T	ENST00000306052.6	-	7	1138	c.1037G>A	c.(1036-1038)gGc>gAc	p.G346D	LRP8_ENST00000347547.2_Missense_Mutation_p.G176D|LRP8_ENST00000354412.3_Missense_Mutation_p.G217D|LRP8_ENST00000465675.1_5'UTR|LRP8_ENST00000371454.2_Missense_Mutation_p.G346D	NM_004631.4	NP_004622.2	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	346	EGF-like 1.				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						GTGTGAGCAGCCGCCATTGTT	0.617000													21	25					0	0	1	0	0
SH3BP5	9467	broad.mit.edu	37	3	15311358	15311358	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:15311358C>T	ENST00000383791.3	-	4	577	c.357G>A	c.(355-357)acG>acA	p.T119T	SH3BP5_ENST00000408919.3_5'UTR|SH3BP5_ENST00000253688.5_5'UTR|SH3BP5_ENST00000465894.2_5'UTR|SH3BP5_ENST00000426925.1_5'UTR	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	119					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						GGAAGTCCTGCGTGGCTTTCT	0.577000													50	65					0	0	1	0	0
TMEM260	54916	broad.mit.edu	37	14	57075837	57075837	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:57075837G>A	ENST00000261556.6	+	6	772	c.650G>A	c.(649-651)gGc>gAc	p.G217D	TMEM260_ENST00000538838.1_Missense_Mutation_p.G217D|TMEM260_ENST00000536419.1_5'UTR	NM_017799.3	NP_060269.3			transmembrane protein 260																		CTCTCCCTGGGCTCTTTGTTG	0.458000													9	268					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30572474	30572474	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:30572474G>C	ENST00000376511.2	-	12	1545	c.993C>G	c.(991-993)agC>agG	p.S331R		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	331	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						GTTTGGCTGTGCTTGGTTCTG	0.532000													80	101					0	0	1	0	0
CAMK1	8536	broad.mit.edu	37	3	9804696	9804696	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:9804696C>A	ENST00000256460.3	-	5	508	c.331G>T	c.(331-333)Ggc>Tgc	p.G111C	OGG1_ENST00000349503.5_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000449570.2_Intron|OGG1_ENST00000302036.7_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	111	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		GTGTAGAAGCCTTTTTCCACA	0.587000													10	11					1.76689e-08	1.86465e-08	1	1	0
DUOX2	50506	broad.mit.edu	37	15	45391660	45391660	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:45391660C>T	ENST00000389039.6	-	26	3821	c.3436G>A	c.(3436-3438)Gca>Aca	p.A1146T	DUOX2_ENST00000603300.1_Missense_Mutation_p.A1146T			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1146	Ferric oxidoreductase.|Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		ACATTGACTGCGTGGCCAGCA	0.537000													11	10					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220505562	220505562	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:220505562G>A	ENST00000358055.3	+	22	4011	c.3499G>A	c.(3499-3501)Gca>Aca	p.A1167T	SLC4A3_ENST00000373760.2_Missense_Mutation_p.A1167T|SLC4A3_ENST00000373762.3_Missense_Mutation_p.A1194T|SLC4A3_ENST00000273063.6_Missense_Mutation_p.A1194T|SLC4A3_ENST00000317151.3_Missense_Mutation_p.A1167T			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	1167	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGCTGCATCGCACTGCTCTG	0.652000													8	17					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	30725231	30725231	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:30725231G>A	ENST00000361762.2	+	1	3195	c.2187G>A	c.(2185-2187)tcG>tcA	p.S729S	PCDH7_ENST00000543491.1_Silent_p.S729S	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	729	Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						CTACAGTCTCGCTTTTTGTGA	0.473000													33	41					0	0	1	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128896711	128896711	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:128896711G>A	ENST00000371106.3	+	19	1897	c.1705G>A	c.(1705-1707)Gaa>Aaa	p.E569K		NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	569					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						GATCCGTCTCGAAGATGTGGC	0.547000													26	6					0	0	1	0	0
CTC-457E21.3	0	broad.mit.edu	37	19	22780125	22780125	+	RNA	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:22780125A>G	ENST00000600260.1	+	0	203					NR_033899.1																						TGGTGTTCCTACAGGAGTGAA	0.473000													18	35					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119327242	119327242	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:119327242G>T	ENST00000522284.1	-	8	1930	c.1555C>A	c.(1555-1557)Ctc>Atc	p.L519I	FAM184A_ENST00000521531.1_Intron|RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000352896.5_Intron|FAM184A_ENST00000368475.4_Intron|FAM184A_ENST00000338891.7_Intron			Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	0										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						agtagaatgagcccttgttcc	0.413000													7	10					8.12818e-05	8.34155e-05	1	1	0
EOGT	285203	broad.mit.edu	37	3	69047213	69047213	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:69047213C>T	ENST00000383701.3	-	10	1522	c.780G>A	c.(778-780)caG>caA	p.Q260Q	EOGT_ENST00000540764.1_Silent_p.Q159Q|EOGT_ENST00000540955.1_Intron|EOGT_ENST00000295571.5_Silent_p.Q260Q	NM_001278689.1	NP_001265618.1			EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase																		TATTAACGTGCTGAGTAATAT	0.383000													54	85					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162864373	162864373	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:162864373C>T	ENST00000366898.1	-	2	242	c.140G>A	c.(139-141)gGg>gAg	p.G47E	PARK2_ENST00000366892.1_Missense_Mutation_p.G47E|PARK2_ENST00000338468.3_5'UTR|PARK2_ENST00000366897.1_Missense_Mutation_p.G47E|PARK2_ENST00000366896.1_Missense_Mutation_p.G47E|PARK2_ENST00000366894.1_5'UTR	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	47	Ubiquitin-like.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CAGCTCCTTCCCTGCGAAAAT	0.597000													11	49					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86037065	86037065	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:86037065T>C	ENST00000414626.2	+	7	1992	c.1103T>C	c.(1102-1104)tTa>tCa	p.L368S	LRRCC1_ENST00000360375.3_Missense_Mutation_p.L388S			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	388					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						CTTAAAGAATTATATGTAAGC	0.303000													55	112					0	0	1	0	0
MSL3P1	0	broad.mit.edu	37	2	234774971	234774971	+	RNA	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:234774971G>A	ENST00000438684.1	-	0	1143					NR_024322.1																						ACAAACAATCGCAGCAAATGT	0.433000													16	58					0	0	1	0	0
TMEM199	147007	broad.mit.edu	37	17	26687828	26687828	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:26687828C>T	ENST00000292114.3	+	5	579	c.489C>T	c.(487-489)tgC>tgT	p.C163C	TMEM199_ENST00000395404.3_5'UTR|TMEM199_ENST00000509083.1_Silent_p.C163C|CTB-96E2.3_ENST00000591482.1_RNA	NM_152464.1	NP_689677.1	Q8N511	TM199_HUMAN	transmembrane protein 199	163						integral to membrane				endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	6	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CCTTCGTCTGCACTTACCTTG	0.537000													45	78					0	0	1	0	0
SOX30	11063	broad.mit.edu	37	5	157078230	157078230	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:157078230A>G	ENST00000265007.6	-	1	1198	c.857T>C	c.(856-858)tTg>tCg	p.L286S	SOX30_ENST00000311371.5_Missense_Mutation_p.L286S|SOX30_ENST00000519442.1_Intron	NM_178424.1	NP_848511.1	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30	286					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	23	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GACCTTGGTCAATCTTATCAG	0.562000													34	59					0	0	1	0	0
ARHGAP1	392	broad.mit.edu	37	11	46703689	46703689	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:46703689T>C	ENST00000311956.4	-	5	458	c.361A>G	c.(361-363)Aca>Gca	p.T121A		NM_004308.2	NP_004299.1	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	121	CRAL-TRIO.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		TACAGAAGTGTGTAGTCACTC	0.622000													34	53					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42263147	42263147	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:42263147G>A	ENST00000361204.4	+	2	567	c.401G>A	c.(400-402)cGc>cAc	p.R134H		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	134	Gln-rich.				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						CTTcagccccgcccccagccc	0.592000													19	26					0	0	1	0	0
AHCYL1	10768	broad.mit.edu	37	1	110559021	110559021	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:110559021G>A	ENST00000369799.5	+	8	1205	c.838G>A	c.(838-840)Gat>Aat	p.D280N	AHCYL1_ENST00000393614.4_Missense_Mutation_p.D233N|AHCYL1_ENST00000359172.3_Missense_Mutation_p.D233N	NM_001242673.1|NM_001242674.1|NM_006621.5	NP_001229602.1|NP_001229603.1|NP_006612.2	O43865	SAHH2_HUMAN	adenosylhomocysteinase-like 1	280					one-carbon metabolic process	endoplasmic reticulum	adenosylhomocysteinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)	18		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0259)|Colorectal(144;0.123)|all cancers(265;0.134)|Epithelial(280;0.141)|LUSC - Lung squamous cell carcinoma(189;0.143)		GAACGTCAATGATTCTGTTAC	0.418000													44	63					0	0	1	0	0
PCDHGC3	0	broad.mit.edu	37	5	140857027	140857027	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:140857027C>T	ENST00000308177.3	+	1	1448	c.1344C>T	c.(1342-1344)tcC>tcT	p.S448S	PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000518882.1_Intron	NM_002588.2|NM_032402.1	NP_002579.2|NP_115778.1														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(2)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCAAGTGTCCGACATCAATG	0.507000													26	40					0	0	1	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47649586	47649586	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:47649586C>T	ENST00000371917.4	+	39	5208	c.5208C>T	c.(5206-5208)taC>taT	p.Y1736Y		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	1736					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CAATGTACTACCCCTACTTGT	0.398000													3	42					0	0	1	0	0
FAM169B	283777	broad.mit.edu	37	15	98995239	98995239	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:98995239C>T	ENST00000558256.1	-	5	434	c.184_splice	c.e5-1	p.G62_splice	FAM169B_ENST00000332908.4_Splice_Site_p.G62_splice	NM_182562.2	NP_872368.2	Q8N8A8	F169B_HUMAN	family with sequence similarity 169, member B	62										large_intestine(3)|lung(3)|urinary_tract(1)	7						ACACAGTCTGCCTGCAGAGAA	0.587000													8	12					0	0	1	0	0
FAM86DP	0	broad.mit.edu	37	3	75476814	75476814	+	RNA	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:75476814C>T	ENST00000459803.1	-	0	542					NR_024241.1																						GCCTGTGAGGCCGGCACCACT	0.622000													7	10					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40657409	40657409	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:40657409C>A	ENST00000406785.1	-	2	201	c.12G>T	c.(10-12)atG>atT	p.M4I	SLC8A1_ENST00000542756.1_Missense_Mutation_p.M4I|SLC8A1_ENST00000542024.1_Missense_Mutation_p.M4I|SLC8A1_ENST00000406391.2_Missense_Mutation_p.M4I|SLC8A1_ENST00000405269.1_Missense_Mutation_p.M4I|SLC8A1_ENST00000402441.1_Missense_Mutation_p.M4I|SLC8A1_ENST00000408028.2_Missense_Mutation_p.M4I|SLC8A1_ENST00000332839.4_Missense_Mutation_p.M4I|SLC8A1_ENST00000403092.1_Missense_Mutation_p.M4I|SLC8A1_ENST00000405901.3_Missense_Mutation_p.M4I			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	4					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TTAATCGCCGCATGTTGTACA	0.428000													17	35					1.15088e-07	1.20771e-07	1	1	0
ZNF485	220992	broad.mit.edu	37	10	44104711	44104711	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:44104711T>C	ENST00000361807.3	+	4	354	c.160T>C	c.(160-162)Tct>Cct	p.S54P	ZNF485_ENST00000374437.2_Intron|ZNF485_ENST00000374435.3_Missense_Mutation_p.S54P	NM_145312.3	NP_660355.2	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	54	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16						AGGGCTTCTCTCTTCCAAACC	0.473000													8	10					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173873302	173873302	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:173873302C>T	ENST00000506823.1	+	10	1921	c.1264C>T	c.(1264-1266)Cgc>Tgc	p.R422C	GALNTL6_ENST00000508122.1_Missense_Mutation_p.R405C	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	422						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						GAAGGAGCTGCGCAAGCAGCT	0.587000													16	23					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53958865	53958865	+	RNA	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:53958865C>A	ENST00000454407.1	+	0	1557							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		ACAAGTCATCCCTTACATGCC	0.428000													5	178					0.014758	0.0148771	1	1	0
GAS2L1	10634	broad.mit.edu	37	22	29708154	29708154	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:29708154G>A	ENST00000406549.3	+	6	1183	c.1033G>A	c.(1033-1035)Gtc>Atc	p.V345I	GAS2L1_ENST00000407854.1_3'UTR|GAS2L1_ENST00000403764.1_3'UTR|GAS2L1_ENST00000471961.1_3'UTR|GAS2L1_ENST00000407647.2_3'UTR|GAS2L1_ENST00000360113.2_3'UTR			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	362					cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						GTCCCTCAGCGTCCTGGGTGG	0.662000													58	74					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85564217	85564217	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:85564217C>T	ENST00000295887.5	+	11	1496	c.1073C>T	c.(1072-1074)gCa>gTa	p.A358V		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	358					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		CACAGCATTGCACTGTCAACC	0.418000													46	81					0	0	1	0	0
PTBP3	9991	broad.mit.edu	37	9	115024862	115024862	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:115024862C>T	ENST00000334318.6	-	6	648	c.462G>A	c.(460-462)ctG>ctA	p.L154L	PTBP3_ENST00000343327.2_Silent_p.L56L|PTBP3_ENST00000487997.1_5'UTR|PTBP3_ENST00000458258.1_Silent_p.L157L|PTBP3_ENST00000374255.2_Silent_p.L151L|PTBP3_ENST00000374257.1_Silent_p.L123L	NM_001163790.2|NM_005156.6	NP_001157262.1|NP_005147.3	O95758	ROD1_HUMAN	polypyrimidine tract binding protein 3	151					anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding										TGACAGCCTGCAGTGCAGCTT	0.458000													15	21					0	0	1	0	0
MUC20	200958	broad.mit.edu	37	3	195452857	195452857	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:195452857G>A	ENST00000320736.6	+	3	996	c.870G>A	c.(868-870)ctG>ctA	p.L290L	MUC20_ENST00000445522.2_Silent_p.L426L|MUC20_ENST00000436408.1_Silent_p.L461L|MUC20_ENST00000447234.2_Silent_p.L461L	NM_001098516.1|NM_152673.2	NP_001091986.1|NP_689886.2	Q8N307	MUC20_HUMAN	mucin 20, cell surface associated	461	12 X 20 AA approximate tandem repeats of S-S-E-S-S-A-S-S-D-S-P-H-P-V-I-T-P-S-R-A.|Ser-rich.		Missing.		protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane				NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)	23	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CACCAGCTCTGCCTGACTCCA	0.582000													7	17					0	0	1	0	0
TERT	0	broad.mit.edu	37	5	1264629	1264629	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1264629G>A	ENST00000310581.5	-	11	2790	c.2733C>T	c.(2731-2733)gaC>gaT	p.D911D	TERT_ENST00000334602.6_Intron|TERT_ENST00000296820.5_3'UTR	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	911	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CCAGGGCCTCGTCTTCTACAG	0.622000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				23	22					0	0	1	0	0
RASA1	5921	broad.mit.edu	37	5	86672218	86672218	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:86672218C>T	ENST00000456692.2	+	16	1604	c.1489C>T	c.(1489-1491)Cgc>Tgc	p.R497C	RASA1_ENST00000506290.1_Missense_Mutation_p.R508C|CTC-428H11.2_ENST00000607486.1_RNA|RASA1_ENST00000512763.1_Missense_Mutation_p.R507C|RASA1_ENST00000274376.6_Missense_Mutation_p.R674C	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1	674	PH.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		AGTATTTATGCGCTGCCAGTT	0.413000													14	24					0	0	1	0	0
FAM81A	145773	broad.mit.edu	37	15	59808970	59808970	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:59808970G>T	ENST00000288228.5	+	8	1100	c.913G>T	c.(913-915)Ggg>Tgg	p.G305W		NM_152450.2	NP_689663.2	Q8TBF8	FA81A_HUMAN	family with sequence similarity 81, member A	305										endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10						GAAGATGCACGGGCGAATCAC	0.463000													4	7					0.00909568	0.00918626	1	1	0
TM9SF2	9375	broad.mit.edu	37	13	100206622	100206622	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:100206622C>T	ENST00000376387.4	+	14	1743	c.1553C>T	c.(1552-1554)aCg>aTg	p.T518M		NM_004800.1	NP_004791.1	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2	518					transport	endosome membrane|integral to plasma membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)	17	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					TCGTTCTACACGAAGCCCTTG	0.403000													30	47					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74091238	74091238	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:74091238C>T	ENST00000443185.2	-	4	3149	c.2832G>A	c.(2830-2832)tcG>tcA	p.S944S	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	944					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		TGCTATTGGCCGAGGGCTGCG	0.677000													11	24					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44151145	44151145	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:44151145C>T	ENST00000223357.3	+	15	2061	c.1756C>T	c.(1756-1758)Cgc>Tgc	p.R586C	AEBP1_ENST00000450684.2_Missense_Mutation_p.R161C	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	586	Interaction with MAPK1 and MAPK3 (By similarity).|Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						CACCATCACCCGCACTTACAG	0.602000													8	14					0	0	1	0	0
FOXRED2	80020	broad.mit.edu	37	22	36889728	36889728	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:36889728G>A	ENST00000397224.4	-	8	1840	c.1747C>T	c.(1747-1749)Cgc>Tgc	p.R583C	FOXRED2_ENST00000366463.3_Missense_Mutation_p.R135C|FOXRED2_ENST00000397223.4_Missense_Mutation_p.R583C|FOXRED2_ENST00000216187.6_Missense_Mutation_p.R583C	NM_001102371.1	NP_001095841.1	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	583					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						TCCAGGAAGCGCCTCAGAGGT	0.547000													18	37					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586419	20586419	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:20586419G>A	ENST00000315543.4	+	1	854	c.854G>A	c.(853-855)tGc>tAc	p.C285Y		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TTTGGCCCATGCATCTTTATC	0.423000													18	30					0	0	1	0	0
CSK	1445	broad.mit.edu	37	15	75091727	75091727	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:75091727C>T	ENST00000220003.9	+	5	1086	c.357C>T	c.(355-357)tgC>tgT	p.C119C	CSK_ENST00000567571.1_Silent_p.C119C|CSK_ENST00000439220.2_Silent_p.C119C|CSK_ENST00000309470.9_Silent_p.C119C	NM_004383.2	NP_004374.1	P41240	CSK_HUMAN	c-src tyrosine kinase	119	SH2.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			central_nervous_system(1)|lung(2)	3						ACACGCTGTGCGTGAGCTGCG	0.607000													4	21					0	0	1	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389587	1389587	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:1389587C>T	ENST00000324803.4	+	1	4248	c.1288C>T	c.(1288-1290)Cgt>Tgt	p.R430C		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	430	Interaction with PAK1.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding	p.R430C(2)		NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CTTTTTAATACGTTTTTATGT	0.443000													20	39					0	0	1	0	0
TMEM225	338661	broad.mit.edu	37	11	123753985	123753985	+	Missense_Mutation	SNP	C	C	T	rs77654932	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:123753985C>T	ENST00000375026.2	-	4	754	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	180						integral to membrane		p.E180K(1)		endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						TCCTTACATTCGTTGTCAGAT	0.443000													22	34					0	0	1	0	0
CRY2	1408	broad.mit.edu	37	11	45883694	45883694	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:45883694C>T	ENST00000443527.2	+	5	821	c.799C>T	c.(799-801)Cgg>Tgg	p.R267W	CRY2_ENST00000417225.2_Missense_Mutation_p.R185W	NM_021117.3	NP_066940.2	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like)	246	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(2)	15						GCACTTGGAACGGAAGGTATG	0.537000													8	22					0	0	1	0	0
AQP9	366	broad.mit.edu	37	15	58430862	58430862	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:58430862C>T	ENST00000219919.4	+	1	468	c.98C>T	c.(97-99)aCg>aTg	p.T33M	AQP9_ENST00000558772.1_Intron|AQP9_ENST00000536493.1_Missense_Mutation_p.T33M|ALDH1A2_ENST00000558231.1_Intron|AQP9_ENST00000559443.1_3'UTR	NM_020980.3	NP_066190.2	O43315	AQP9_HUMAN	aquaporin 9	33					cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)	21				GBM - Glioblastoma multiforme(80;0.16)		TTCTTGGGCACGTTCATCTTG	0.458000													24	46					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22052051	22052051	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:22052051G>A	ENST00000306385.5	+	11	2061	c.1391G>A	c.(1390-1392)cGg>cAg	p.R464Q	BMP1_ENST00000397816.3_Missense_Mutation_p.R464Q|BMP1_ENST00000354870.5_3'UTR|BMP1_ENST00000397814.3_Missense_Mutation_p.R464Q|BMP1_ENST00000306349.8_Missense_Mutation_p.R464Q	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	464	CUB 2.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		TGCATCTGGCGGATCCAGGTG	0.562000													14	31					0	0	1	0	0
OR2T4	127074	broad.mit.edu	37	1	248525007	248525007	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:248525007C>T	ENST00000366475.1	+	1	125	c.125C>T	c.(124-126)tCg>tTg	p.S42L		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACTGGATGGTCGGATTTCATC	0.473000													38	12					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156618630	156618630	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:156618630G>A	ENST00000329117.4	+	6	1376	c.1040G>A	c.(1039-1041)cGc>cAc	p.R347H	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000361588.5_Missense_Mutation_p.R347H	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	347	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AAGCACAGCCGCTTCAACGTC	0.572000													91	10					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41554480	41554480	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:41554480C>T	ENST00000263253.7	+	19	4785	c.3566C>T	c.(3565-3567)gCc>gTc	p.A1189V		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1189					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CCTCGTGATGCCACTTATTAC	0.498000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				6	19					0	0	1	0	0
JOSD1	9929	broad.mit.edu	37	22	39084972	39084972	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:39084972C>T	ENST00000216039.5	-	3	1156	c.477G>A	c.(475-477)atG>atA	p.M159I		NM_014876.5	NP_055691.1	Q15040	JOS1_HUMAN	Josephin domain containing 1	159	Josephin.						peptidase activity			large_intestine(1)|lung(1)|ovary(2)|pancreas(1)	5	Melanoma(58;0.04)					TCCACTCGGGCATCTTGAGTT	0.537000													36	53					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124831384	124831384	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:124831384G>A	ENST00000356219.3	-	32	4261	c.4106C>T	c.(4105-4107)tCc>tTc	p.S1369F	NCOR2_ENST00000404621.1_Missense_Mutation_p.S1352F|NCOR2_ENST00000429285.2_Missense_Mutation_p.S1352F|NCOR2_ENST00000405201.1_Missense_Mutation_p.S1362F|NCOR2_ENST00000404121.2_Missense_Mutation_p.S923F|NCOR2_ENST00000397355.1_Missense_Mutation_p.S1353F	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1370					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CTCCACGTAGGACCGAGGGAT	0.687000													5	3					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3778309	3778309	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:3778309C>T	ENST00000310132.6	-	14	1794	c.1396G>A	c.(1396-1398)Gcc>Acc	p.A466T	MATK_ENST00000395040.2_Missense_Mutation_p.A425T|MATK_ENST00000585778.1_Missense_Mutation_p.A465T|MATK_ENST00000395045.2_Missense_Mutation_p.A467T	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	466	Protein kinase.			ARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQE P -> PAGHPSANWPRSWPGSYAVQVPQPPSQGRTPTVHLA PKPGALTPPGGPWPQRTERVESAAWGH (in Ref. 1; AAA16703).	cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCGGCGGGCGGGCTCTGCC	0.716000													13	23					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27101587	27101587	+	Silent	SNP	G	G	A	rs148936933	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:27101587G>A	ENST00000324856.7	+	18	5240	c.4869G>A	c.(4867-4869)tcG>tcA	p.S1623S	ARID1A_ENST00000374152.2_Silent_p.S1240S|ARID1A_ENST00000540690.1_Intron|ARID1A_ENST00000457599.2_Silent_p.S1406S	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1623					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TACCTGCCTCGCACATAGCAC	0.597000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								25	28					0	0	1	0	0
ESYT3	83850	broad.mit.edu	37	3	138191607	138191607	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:138191607G>A	ENST00000389567.4	+	18	2329	c.2143G>A	c.(2143-2145)Gca>Aca	p.A715T		NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	715						integral to membrane|plasma membrane				breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						CTCCCCATTCGCATGGCCGCC	0.577000													28	39					0	0	1	0	0
PLEK2	26499	broad.mit.edu	37	14	67854066	67854066	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:67854066C>T	ENST00000216446.4	-	9	1182	c.1042G>A	c.(1042-1044)Gct>Act	p.A348T		NM_016445.1	NP_057529.1	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	348	PH 2.				actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	15				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		TTTTTGATAGCTTCAATCCAC	0.478000													40	56					0	0	1	0	0
REEP1	65055	broad.mit.edu	37	2	86509339	86509339	+	Missense_Mutation	SNP	G	G	A	rs121918262		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:86509339G>A	ENST00000165698.5	-	2	202	c.59C>T	c.(58-60)gCg>gTg	p.A20V	REEP1_ENST00000473407.1_5'UTR|REEP1_ENST00000535845.1_Intron|REEP1_ENST00000538924.1_Missense_Mutation_p.A27V|REEP1_ENST00000540790.1_5'UTR|REEP1_ENST00000541910.1_Missense_Mutation_p.A20V	NM_022912.2	NP_075063.1	Q9H902	REEP1_HUMAN	receptor accessory protein 1	20			A -> E (in SPG31).		cell death|protein insertion into membrane	integral to membrane|mitochondrial membrane	olfactory receptor binding			breast(1)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	13						GGAATAATACGCAGGGTAAAG	0.388000													56	95					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103406213	103406213	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:103406213G>A	ENST00000361246.2	-	33	4951	c.4663C>T	c.(4663-4665)Cgg>Tgg	p.R1555W		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1555					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		AAGACGAACCGCCTTTTGCTC	0.647000													73	101					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43937194	43937194	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:43937194G>T	ENST00000282406.4	+	12	2142	c.2032G>T	c.(2032-2034)Gac>Tac	p.D678Y		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	678						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTACTCCACAGACACGGAGTA	0.388000													38	58					2.19358e-23	2.44412e-23	1	1	0
EIF2AK4	440275	broad.mit.edu	37	15	40290965	40290965	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:40290965G>A	ENST00000263791.5	+	20	2945	c.2902G>A	c.(2902-2904)Gat>Aat	p.D968N	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.D940N	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	968	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AGACTTTGACGATGGAGAGCA	0.348000													14	69					0	0	1	0	0
LILRB2	0	broad.mit.edu	37	19	54778648	54778648	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:54778648G>A	ENST00000391748.1	-	14	1810	c.1683C>T	c.(1681-1683)taC>taT	p.Y561Y	LILRB2_ENST00000434421.1_Silent_p.Y446Y|LILRB2_ENST00000391749.4_Silent_p.Y562Y|LILRB2_ENST00000391746.1_3'UTR|LILRB2_ENST00000314446.5_Silent_p.Y561Y	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	562					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCAGCTGGGCGTAGGTCACAT	0.652000													14	28					0	0	1	0	0
RBPJL	11317	broad.mit.edu	37	20	43940962	43940962	+	Silent	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:43940962T>C	ENST00000343694.3	+	6	618	c.546T>C	c.(544-546)ggT>ggC	p.G182G	RBPJL_ENST00000372743.1_Silent_p.G182G|RBPJL_ENST00000372741.3_Silent_p.G182G	NM_014276.2	NP_055091.2	Q9UBG7	RBPJL_HUMAN	recombination signal binding protein for immunoglobulin kappa J region-like	182					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Myeloproliferative disorder(115;0.0122)				GGGAGCTGGGTACCTTCCACA	0.622000													7	8					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67683981	67683981	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:67683981C>T	ENST00000334583.6	+	22	2440	c.2112C>T	c.(2110-2112)cgC>cgT	p.R704R	RLTPR_ENST00000545661.1_Silent_p.R668R	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	704										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGAACAACCGCGCAGACCCTG	0.597000													3	12					0	0	1	0	0
KRT40	125115	broad.mit.edu	37	17	39137273	39137273	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39137273C>T	ENST00000377755.4	-	4	852	c.818G>A	c.(817-819)cGc>cAc	p.R273H	KRT40_ENST00000398486.2_Missense_Mutation_p.R273H			Q6A162	K1C40_HUMAN	keratin 40	273	Coil 2.|Rod.					intermediate filament	structural molecule activity			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Breast(137;0.00043)				AGCTTCTCTGCGATTGTTGGC	0.507000													52	201					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16387065	16387065	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:16387065C>T	ENST00000354981.2	-	16	1806	c.1649G>A	c.(1648-1650)cGc>cAc	p.R550H	KIF16B_ENST00000378003.2_5'UTR|KIF16B_ENST00000408042.1_Missense_Mutation_p.R550H|KIF16B_ENST00000355755.3_Missense_Mutation_p.R550H	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	550					cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						ATGGTTAAAGCGAAACATATT	0.463000													24	66					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84270469	84270469	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:84270469C>T	ENST00000568181.1	-	2	743	c.623G>A	c.(622-624)cGc>cAc	p.R208H	KCNG4_ENST00000308251.4_Missense_Mutation_p.R208H			Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	208						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						CACCATCTCGCGCAGCCGGTT	0.677000													14	23					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25480619	25480619	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:25480619C>T	ENST00000381884.4	-	7	1742	c.1557G>A	c.(1555-1557)aaG>aaA	p.K519K	CENPJ_ENST00000545981.1_Silent_p.K519K	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	519					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		TACCTTGTGTCTTATTCCACC	0.453000													28	62					0	0	1	0	0
RPLP0	6175	broad.mit.edu	37	12	120637005	120637005	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:120637005C>T	ENST00000551150.1	-	3	549	c.234G>A	c.(232-234)ctG>ctA	p.L78L	RPLP0_ENST00000392514.4_Silent_p.L78L|RPLP0_ENST00000313104.5_Silent_p.L78L|RPLP0_ENST00000228306.4_Silent_p.L78L|RPLP0_ENST00000550296.1_5'UTR|RPLP0_ENST00000546989.1_Silent_p.L78L			P05388	RLA0_HUMAN	ribosomal protein, large, P0	78					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TATGAGGCAGCAGTCTGCAAA	0.527000													12	19					0	0	1	0	0
GSTP1	2950	broad.mit.edu	37	11	67352222	67352222	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:67352222C>T	ENST00000398606.3	+	4	460	c.211C>T	c.(211-213)Cgt>Tgt	p.R71C	GSTP1_ENST00000498765.1_3'UTR|GSTP1_ENST00000398603.1_Missense_Mutation_p.R71C	NM_000852.3	NP_000843.1	P09211	GSTP1_HUMAN	glutathione S-transferase pi 1	71	GST N-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			central_nervous_system(1)|cervix(1)|endometrium(4)|lung(2)|ovary(1)	9					Ethacrynic acid(DB00903)|Glutathione(DB00143)	TACCATCCTGCGTCACCTGGG	0.612000													10	42					0	0	1	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28209961	28209961	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:28209961G>A	ENST00000284984.2	-	9	3295	c.2841C>T	c.(2839-2841)agC>agT	p.S947S		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	947	TSP type-1 3.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		AAGGATCACAGCTCTCATGAG	0.428000													37	9					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26463214	26463214	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:26463214C>T	ENST00000265944.5	+	30	4187	c.4021C>T	c.(4021-4023)Cag>Tag	p.Q1341*	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1341					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						ACCAGTGACACAGGCCCAGGA	0.507000													23	23					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93489284	93489284	+	Silent	SNP	G	G	A	rs144294063	by1000genomes	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:93489284G>A	ENST00000394196.4	+	12	2283	c.1215G>A	c.(1213-1215)ccG>ccA	p.P405P	CHD2_ENST00000557381.1_Silent_p.P405P|CHD2_ENST00000536619.1_Silent_p.P418P|CHD2_ENST00000420239.2_Silent_p.P405P	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	405	Chromo 2.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GTCGGAAGCCGGCACCCTCAA	0.363000													35	47					0	0	1	0	0
RNPEP	6051	broad.mit.edu	37	1	201972553	201972553	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:201972553C>T	ENST00000295640.4	+	9	1658	c.1615C>T	c.(1615-1617)Ctg>Ttg	p.L539L	RP11-465N4.4_ENST00000419190.1_RNA|RNPEP_ENST00000471105.1_3'UTR|RNPEP_ENST00000367286.3_Silent_p.L500L	NM_020216.3	NP_064601.3	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase (aminopeptidase B)	539					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			breast(1)|endometrium(4)|large_intestine(4)|lung(6)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		GGTCTACTTCCTGGATAAGAT	0.547000													9	13					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102516426	102516426	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:102516426C>T	ENST00000360184.4	+	77	13867	c.13703C>T	c.(13702-13704)gCc>gTc	p.A4568V	RP11-1017G21.4_ENST00000557242.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	4568					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CTTCAAGGGGCCACGTGCAAC	0.567000													25	36					0	0	1	0	0
AADACL3	126767	broad.mit.edu	37	1	12785858	12785858	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:12785858G>T	ENST00000332530.3	+	3	964	c.738G>T	c.(736-738)gaG>gaT	p.E246D	AADACL3_ENST00000359318.5_Missense_Mutation_p.E316D	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	316							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		ACCATATGGAGGATGGTTTCC	0.493000													20	37					1.01871e-10	1.09092e-10	1	1	0
ADAM20	8748	broad.mit.edu	37	14	70990158	70990158	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:70990158A>G	ENST00000256389.3	-	2	1711	c.1467T>C	c.(1465-1467)tgT>tgC	p.C489C	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	439	Disintegrin.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GATGTAGAGTACAGTTTAACA	0.443000													33	58					0	0	1	0	0
LMNB2	84823	broad.mit.edu	37	19	2434506	2434506	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2434506G>A	ENST00000325327.3	-	7	1051	c.989C>T	c.(988-990)gCc>gTc	p.A330V	LMNB2_ENST00000582871.1_Missense_Mutation_p.A310V			Q03252	LMNB2_HUMAN	lamin B2	310	Coil 2.|Rod.					nuclear inner membrane	structural molecule activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCTTCAGCGGCACTGGCCTG	0.667000													8	11					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64606548	64606548	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:64606548G>T	ENST00000342711.5	-	7	832	c.833C>A	c.(832-834)gCt>gAt	p.A278D		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	278	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						CAAGGACTCAGCATAGAAGGG	0.607000													13	18					4.3838e-07	4.58243e-07	1	1	0
FBXO33	254170	broad.mit.edu	37	14	39871008	39871008	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:39871008G>A	ENST00000298097.7	-	3	1105	c.768C>T	c.(766-768)tcC>tcT	p.S256S	FBXO33_ENST00000554190.1_Intron	NM_203301.3	NP_976046.1	Q7Z6M2	FBX33_HUMAN	F-box protein 33	256										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|urinary_tract(1)	9	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		TAAACCCACAGGACAGCCATT	0.408000													22	83					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118231318	118231318	+	Missense_Mutation	SNP	G	G	A	rs150059984		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118231318G>A	ENST00000369230.3	+	10	1245	c.1099G>A	c.(1099-1101)Gaa>Aaa	p.E367K		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	367	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		CAGTGGAAGCGAAGTCACTCA	0.448000													8	85					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203025990	203025990	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:203025990G>T	ENST00000367240.2	+	18	2783	c.2256G>T	c.(2254-2256)aaG>aaT	p.K752N	PPFIA4_ENST00000272198.6_Missense_Mutation_p.K267N|PPFIA4_ENST00000414050.2_Missense_Mutation_p.K480N|PPFIA4_ENST00000599966.1_Missense_Mutation_p.K267N|PPFIA4_ENST00000447715.2_Missense_Mutation_p.K751N|PPFIA4_ENST00000295706.4_Missense_Mutation_p.K267N			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	267					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						CCAAGCGCAAGGGCATCAAGT	0.622000													16	19					2.31682e-05	2.39009e-05	1	1	0
COL16A1	1307	broad.mit.edu	37	1	32157644	32157644	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:32157644C>T	ENST00000373672.3	-	17	1735	c.1219G>A	c.(1219-1221)Gga>Aga	p.G407R	COL16A1_ENST00000373668.3_Missense_Mutation_p.G407R|COL16A1_ENST00000271069.6_Missense_Mutation_p.G407R	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	407	Triple-helical region 9 (COL9) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TTGATGCCTCCGTCGCCCTTC	0.647000													36	78					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85626574	85626574	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:85626574G>A	ENST00000322366.6	-	53	8664	c.8257C>T	c.(8257-8259)Cgg>Tgg	p.R2753W	WDFY3_ENST00000295888.4_Missense_Mutation_p.R2770W			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2770	BEACH.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCTTTATACCGCTTCTTATAC	0.403000													9	99					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237798	29237798	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:29237798C>T	ENST00000382535.3	+	2	1682	c.1313C>T	c.(1312-1314)gCc>gTc	p.A438V	FOXG1_ENST00000313071.4_Missense_Mutation_p.A438V			P55316	FOXG1_HUMAN	forkhead box G1	438					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		AGCGCCAGGGCCGCGTCCTCC	0.632000													24	31					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43319071	43319071	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:43319071C>T	ENST00000374518.4	+	21	3358	c.3295C>T	c.(3295-3297)Cga>Tga	p.R1099*		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	1099					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TGTCTTCATGCGAACTTGGTA	0.388000													14	35					0	0	1	0	0
KRT9	3857	broad.mit.edu	37	17	39723557	39723557	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:39723557C>T	ENST00000246662.4	-	7	1905	c.1840G>A	c.(1840-1842)Gga>Aga	p.G614R	KRT9_ENST00000588431.1_Missense_Mutation_p.G381R	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	614	Tail.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				cttcctcctccgtagccgcca	0.532000													31	33					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171251207	171251207	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:171251207A>G	ENST00000354841.4	+	6	1049	c.918A>G	c.(916-918)gtA>gtG	p.V306V	FMO1_ENST00000367750.3_Silent_p.V306V|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000402921.2_Silent_p.V243V			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	306					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TAAAAGAGGTAAAGGAAAACT	0.408000													28	34					0	0	1	0	0
RSC1A1	6248	broad.mit.edu	37	1	15987989	15987989	+	Silent	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:15987989C>A	ENST00000345034.1	+	1	1626	c.1626C>A	c.(1624-1626)gtC>gtA	p.V542V	DDI2_ENST00000480945.1_3'UTR	NM_006511.1	NP_006502.1	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1, member 1	542					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)	11		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAGAAAATGTCTGTCCTGATG	0.428000													57	72					1.77205e-36	1.98959e-36	1	1	0
EXOC4	60412	broad.mit.edu	37	7	133580444	133580444	+	Silent	SNP	C	C	T	rs34995232		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:133580444C>T	ENST00000253861.4	+	12	1856	c.1827C>T	c.(1825-1827)tgC>tgT	p.C609C	EXOC4_ENST00000460346.1_3'UTR|EXOC4_ENST00000545148.1_Silent_p.C219C|EXOC4_ENST00000539845.1_Silent_p.C508C	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	609					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				ACATGGTGTGCGTGAAGCTCC	0.473000													9	52					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76464776	76464776	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:76464776C>T	ENST00000389840.5	-	55	8783	c.8659G>A	c.(8659-8661)Gtc>Atc	p.V2887I	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.V2896I					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGGGACTTGACTTGGGGTCGC	0.542000													16	30					0	0	1	0	0
TFDP1	7027	broad.mit.edu	37	13	114288234	114288234	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:114288234C>T	ENST00000375370.5	+	7	716	c.504C>T	c.(502-504)cgC>cgT	p.R168R	TFDP1_ENST00000544902.1_Silent_p.R73R|TFDP1_ENST00000465174.1_3'UTR|TFDP1_ENST00000538138.1_Silent_p.R73R	NM_007111.4	NP_009042.1	Q14186	TFDP1_HUMAN	transcription factor Dp-1	168					cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			TAAGACGGCGCGTCTACGATG	0.488000										TSP Lung(29;0.18)			18	74					0	0	1	0	0
C3AR1	719	broad.mit.edu	37	12	8211772	8211772	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:8211772G>A	ENST00000307637.4	-	2	1213	c.1010C>T	c.(1009-1011)aCg>aTg	p.T337M		NM_004054.2	NP_004045.1	Q16581	C3AR_HUMAN	complement component 3a receptor 1	337					blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity	p.T337M(1)		breast(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)	20				Kidney(36;0.0893)		CCTAGTGATCGTTATTGCCAC	0.488000													26	44					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	8387204	8387204	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:8387204C>T	ENST00000332175.8	+	29	5177	c.4140C>T	c.(4138-4140)ggC>ggT	p.G1380G	PTPRM_ENST00000444013.1_Silent_p.G1167G|PTPRM_ENST00000400053.4_Silent_p.G1318G|PTPRM_ENST00000400060.4_Silent_p.G1394G|PTPRM_ENST00000580170.1_Silent_p.G1393G	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1380	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				AGTACAATGGCGGGGAAGGCC	0.552000													21	16					0	0	1	0	0
ZNF629	23361	broad.mit.edu	37	16	30794560	30794560	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:30794560C>T	ENST00000262525.4	-	3	1296	c.1089G>A	c.(1087-1089)aaG>aaA	p.K363K		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	363					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			TCCGCTGGTGCTTGATGAGGG	0.657000													9	17					0	0	1	0	0
LRFN3	79414	broad.mit.edu	37	19	36430574	36430574	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36430574A>G	ENST00000588831.1	+	3	1301	c.247A>G	c.(247-249)Aca>Gca	p.T83A	LRFN3_ENST00000246529.3_Missense_Mutation_p.T83A			Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III domain containing 3	83					cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane				cervix(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	12	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGCCAACATGACAGGCCTGCT	0.711000													3	18					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	30958414	30958414	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:30958414G>A	ENST00000298139.5	+	18	2280	c.2031G>A	c.(2029-2031)ggG>ggA	p.G677G		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	677	Helicase ATP-binding.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CTGAGTGGGGGCATGATTTTA	0.408000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				11	29					0	0	1	0	0
ATPAF2	91647	broad.mit.edu	37	17	17927995	17927995	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:17927995G>A	ENST00000474627.3	-	5	600	c.446C>T	c.(445-447)aCa>aTa	p.T149I	ATPAF2_ENST00000469327.1_5'UTR|ATPAF2_ENST00000585101.1_Silent_p.D100D	NM_145691.3	NP_663729.1	Q8N5M1	ATPF2_HUMAN	ATP synthase mitochondrial F1 complex assembly factor 2	149					proton-transporting ATP synthase complex assembly	mitochondrion|nuclear speck	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	8	all_neural(463;0.228)					TTCCACTAATGTCTCGGGCTC	0.413000													43	50					0	0	1	0	0
TPM2	7169	broad.mit.edu	37	9	35689221	35689221	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:35689221C>A	ENST00000378292.3	-	2	1364	c.162G>T	c.(160-162)gaG>gaT	p.E54D	TPM2_ENST00000360958.2_Missense_Mutation_p.E54D|TPM2_ENST00000329305.2_Missense_Mutation_p.E54D|TPM2_ENST00000378300.5_Missense_Mutation_p.E54D	NM_213674.1	NP_998839.1	P07951	TPM2_HUMAN	tropomyosin 2 (beta)	54					muscle filament sliding|regulation of ATPase activity	cytosol|muscle thin filament tropomyosin	actin binding|structural constituent of muscle			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_epithelial(49;0.121)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CCACCTCATCCTCTGTCCCCT	0.602000													18	33					1.45105e-14	1.58388e-14	1	1	0
ATP13A5	344905	broad.mit.edu	37	3	193052824	193052824	+	Silent	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:193052824A>G	ENST00000342358.4	-	10	1125	c.1008T>C	c.(1006-1008)tgT>tgC	p.C336C		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	336					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CCAAACTGTGACATTTCCAAG	0.448000													37	69					0	0	1	0	0
ACTN4	81	broad.mit.edu	37	19	39191247	39191247	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:39191247C>T	ENST00000252699.2	+	2	246	c.170C>T	c.(169-171)aCg>aTg	p.T57M	ACTN4_ENST00000390009.3_Intron|ACTN4_ENST00000424234.2_Missense_Mutation_p.T57M	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	57	Actin-binding.|CH 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CAGACCTTCACGGCATGGTGC	0.607000													15	26					0	0	1	0	0
HELQ	113510	broad.mit.edu	37	4	84342850	84342850	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:84342850A>G	ENST00000295488.3	-	15	2977	c.2815T>C	c.(2815-2817)Ttt>Ctt	p.F939L	HELQ_ENST00000510985.1_Missense_Mutation_p.F872L	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	939							ATP binding|ATP-dependent helicase activity|nucleic acid binding	p.F939V(1)		breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						TAAAGAACAAAAGACAGATAT	0.338000								Other identified genes with known or suspected DNA repair function					14	27					0	0	1	0	0
RNF43	54894	broad.mit.edu	37	17	56435456	56435456	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:56435456G>A	ENST00000584437.1	-	8	3636	c.1681C>T	c.(1681-1683)Cgg>Tgg	p.R561W	BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000407977.2_Missense_Mutation_p.R561W|RNF43_ENST00000500597.2_Missense_Mutation_p.R520W|RNF43_ENST00000577625.1_Missense_Mutation_p.R434W|RNF43_ENST00000583753.1_Missense_Mutation_p.R520W|RNF43_ENST00000577716.1_Missense_Mutation_p.R561W|RNF43_ENST00000581868.1_Missense_Mutation_p.R434W			Q68DV7	RNF43_HUMAN	ring finger protein 43	561						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CACTGGAACCGCTTTTTGTAG	0.632000													19	61					0	0	1	0	0
CCDC170	80129	broad.mit.edu	37	6	151869452	151869452	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:151869452G>A	ENST00000367290.5	+	5	691	c.602G>A	c.(601-603)cGc>cAc	p.R201H	CCDC170_ENST00000239374.7_Missense_Mutation_p.R201H			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	201								p.R201H(1)									AGAGACCTGCGCAAAGAAAAT	0.353000													7	17					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48149394	48149394	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:48149394C>T	ENST00000311303.3	-	13	2266	c.1921G>A	c.(1921-1923)Gtc>Atc	p.V641I	ABCC12_ENST00000448542.1_Missense_Mutation_p.V641I|ABCC12_ENST00000416054.1_Silent_p.T616T	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	641	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				TCCTCAAAGACGTGCTTCCCC	0.617000													41	39					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100128604	100128604	+	Splice_Site	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:100128604T>C	ENST00000394899.2	-	7	1056	c.964_splice	c.e7+1	p.G321_splice	RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000407820.2_Splice_Site_p.G112_splice|ADH6_ENST00000394897.1_Intron|ADH6_ENST00000237653.7_Splice_Site_p.G321_splice	NM_001102470.1	NP_001095940.1	P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	321					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	CATCCATACCTCCAAAAACAG	0.453000													27	33					0	0	1	0	0
ENOX2	10495	broad.mit.edu	37	X	129813662	129813662	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:129813662C>T	ENST00000338144.3	-	7	818	c.401G>A	c.(400-402)gGt>gAt	p.G134D	ENOX2_ENST00000492263.1_5'UTR|ENOX2_ENST00000370927.1_Missense_Mutation_p.G134D|ENOX2_ENST00000394363.1_Missense_Mutation_p.G105D|ENOX2_ENST00000370935.1_Missense_Mutation_p.G105D	NM_182314.1	NP_872114.1	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2	134	RRM.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(3)	33						TTCAGGCAGACCACCCACAAA	0.433000													36	8					0	0	1	0	0
ASPRV1	151516	broad.mit.edu	37	2	70188206	70188206	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:70188206C>T	ENST00000320256.4	-	1	1191	c.615G>A	c.(613-615)gtG>gtA	p.V205V		NM_152792.2	NP_690005.2	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1	205					protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			endometrium(3)|large_intestine(4)|lung(6)|ovary(1)	14						ACCTCACGGGCACTTTGCCAA	0.602000													19	37					0	0	1	0	0
VAT1	10493	broad.mit.edu	37	17	41168121	41168121	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:41168121A>G	ENST00000355653.3	-	6	1234	c.1139T>C	c.(1138-1140)gTg>gCg	p.V380A	VAT1_ENST00000420567.3_Missense_Mutation_p.V246A|VAT1_ENST00000587173.1_Missense_Mutation_p.V312A	NM_006373.3	NP_006364.2	Q99536	VAT1_HUMAN	vesicle amine transport 1	380						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	9		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		GACCTTGCCCACATTCTTCTT	0.552000													79	147					0	0	1	0	0
WWOX	51741	broad.mit.edu	37	16	78466627	78466627	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:78466627C>T	ENST00000566780.1	+	8	1400	c.1034C>T	c.(1033-1035)gCg>gTg	p.A345V	WWOX_ENST00000402655.2_Intron|WWOX_ENST00000406884.2_Intron|WWOX_ENST00000539474.2_Intron|WWOX_ENST00000408984.3_Missense_Mutation_p.A345V	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	345	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TTTACCTTGGCGAGGCCTTTC	0.532000													53	97					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14482807	14482807	+	Silent	SNP	C	C	T	rs139448086		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:14482807C>T	ENST00000344204.4	+	46	6606	c.6582C>T	c.(6580-6582)atC>atT	p.I2194I	TRIO_ENST00000537187.1_Silent_p.I2194I	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2194	PH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TTGAGCAGATCGTCATATTCA	0.478000													31	49					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2740187	2740187	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:2740187C>T	ENST00000312371.4	+	2	470	c.102C>T	c.(100-102)tcC>tcT	p.S34S	AMZ1_ENST00000407112.1_Silent_p.S34S	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	34							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		TGTATGTGTCCGCCTTCTCCC	0.657000													37	60					0	0	1	0	0
MECP2	4204	broad.mit.edu	37	X	153297982	153297982	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:153297982A>G	ENST00000303391.6	-	3	302	c.53T>C	c.(52-54)cTc>cCc	p.L18P	MECP2_ENST00000407218.1_Missense_Mutation_p.L18P|MECP2_ENST00000480620.1_5'UTR|MECP2_ENST00000453960.2_Missense_Mutation_p.L30P	NM_004992.3	NP_004983.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	18					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GAGGCCCTGGAGGTCCTGGTC	0.478000													36	9					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37494485	37494485	+	Missense_Mutation	SNP	G	G	A	rs113803353	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:37494485G>A	ENST00000381792.2	-	3	447	c.307C>T	c.(307-309)Cgc>Tgc	p.R103C	TMPRSS6_ENST00000346753.3_Missense_Mutation_p.R112C|TMPRSS6_ENST00000442782.2_Missense_Mutation_p.R112C|TMPRSS6_ENST00000406725.1_Missense_Mutation_p.R103C|TMPRSS6_ENST00000406856.1_Missense_Mutation_p.R103C			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	112					angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						GTTTCACTGCGGAAGGCACTA	0.567000													98	137					0	0	1	0	0
BTRC	8945	broad.mit.edu	37	10	103221813	103221813	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:103221813C>T	ENST00000370187.3	+	3	350	c.232C>T	c.(232-234)Cag>Tag	p.Q78*	BTRC_ENST00000408038.2_Nonsense_Mutation_p.Q42*|BTRC_ENST00000393441.4_Intron	NM_033637.3	NP_378663.1	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing E3 ubiquitin protein ligase	78					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				endometrium(4)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	27		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		TTCACTTAGACAGGTATGAAA	0.373000													17	25					0	0	1	0	0
FAM154A	158297	broad.mit.edu	37	9	18928482	18928482	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:18928482G>A	ENST00000380534.4	-	4	1272	c.993C>T	c.(991-993)tgC>tgT	p.C331C	FAM154A_ENST00000542071.1_Silent_p.C139C|FAM154A_ENST00000380530.1_3'UTR	NM_153707.2	NP_714918.2	Q8IYX7	F154A_HUMAN	family with sequence similarity 154, member A	331								p.C331C(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|skin(1)	26				GBM - Glioblastoma multiforme(50;6.53e-16)		CAAAGCGACCGCACTTCTTAA	0.562000													15	15					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21860888	21860888	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:21860888C>A	ENST00000399982.2	-	33	6613	c.6549G>T	c.(6547-6549)caG>caT	p.Q2183H	CHD8_ENST00000430710.3_Missense_Mutation_p.Q1904H|CHD8_ENST00000557364.1_Missense_Mutation_p.Q2183H	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2183					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTACCATTTCCTGGCTCCTAC	0.522000													12	68					7.03913e-09	7.44699e-09	1	1	0
ME2	4200	broad.mit.edu	37	18	48439250	48439250	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:48439250A>G	ENST00000321341.5	+	4	594	c.322A>G	c.(322-324)Atg>Gtg	p.M108V	ME2_ENST00000382927.3_Missense_Mutation_p.M108V	NM_002396.4	NP_002387.1	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	108					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(3)	23		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	TGAGAGTTTAATGCCAATTGT	0.338000													37	64					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70007391	70007391	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:70007391C>T	ENST00000355303.5	+	17	2008	c.1703C>T	c.(1702-1704)gCa>gTa	p.A568V	ANO1_ENST00000398543.2_Missense_Mutation_p.A422V|ANO1_ENST00000530676.1_Missense_Mutation_p.A422V|ANO1_ENST00000531349.1_Missense_Mutation_p.A277V|ANO1_ENST00000316296.5_Missense_Mutation_p.A510V|ANO1_ENST00000538023.1_Missense_Mutation_p.A568V	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	568					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						ACAGCCACCGCAGTCATCATC	0.587000													23	49					0	0	1	0	0
KLHL23	151230	broad.mit.edu	37	2	170592130	170592130	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:170592130G>A	ENST00000392647.2	+	2	850	c.606G>A	c.(604-606)gaG>gaA	p.E202E	KLHL23_ENST00000272797.4_Silent_p.E202E|KLHL23_ENST00000602521.1_Intron	NM_144711.5	NP_653312.2	Q8NBE8	KLH23_HUMAN	kelch-like family member 23	202	BACK.									breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	16						CTATCATAGAGCCAGTTATTA	0.353000													26	32					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	464517	464517	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:464517C>T	ENST00000512944.1	+	10	1955	c.1766C>T	c.(1765-1767)cCg>cTg	p.P589L	EXOC3_ENST00000315013.5_Missense_Mutation_p.P589L	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	600					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ATTAAAAAGCCGTATAAGAAG	0.468000													12	38					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105438945	105438945	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:105438945G>A	ENST00000264122.4	-	10	1674	c.1353C>T	c.(1351-1353)gaC>gaT	p.D451D	CBLB_ENST00000405772.1_Silent_p.D451D|CBLB_ENST00000403724.1_Silent_p.D451D|CBLB_ENST00000545639.1_3'UTR|CBLB_ENST00000394027.3_Silent_p.D473D	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	451					cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						GATCATCATCGTCGTCCAAGT	0.478000			Mis S		AML								20	27					0	0	1	0	0
DAG1	1605	broad.mit.edu	37	3	49568797	49568797	+	Missense_Mutation	SNP	G	G	A	rs78720195		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:49568797G>A	ENST00000545947.1	+	6	1575	c.853G>A	c.(853-855)Gca>Aca	p.A285T	DAG1_ENST00000539901.1_Missense_Mutation_p.A285T|DAG1_ENST00000515359.2_Missense_Mutation_p.A285T|DAG1_ENST00000538711.1_Missense_Mutation_p.A285T|DAG1_ENST00000308775.2_Missense_Mutation_p.A285T|DAG1_ENST00000541308.1_Missense_Mutation_p.A285T	NM_001177634.2	NP_001171105.1	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	285	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CAGGGAGGGCGCAATGTCTGC	0.602000													15	21					0	0	1	0	0
CCDC174	51244	broad.mit.edu	37	3	14695972	14695972	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:14695972G>A	ENST00000383794.3	+	2	155	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	CCDC174_ENST00000303688.7_Missense_Mutation_p.E28K	NM_016474.4	NP_057558.3			coiled-coil domain containing 174																		AAAGCAAGAAGAATTCAAACA	0.323000													8	18					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167262766	167262766	+	Missense_Mutation	SNP	G	G	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:167262766G>T	ENST00000409855.1	-	25	4499	c.4373C>A	c.(4372-4374)cCt>cAt	p.P1458H		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	1458					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						TTGAGTCCCAGGGTTAATTTT	0.383000													24	42					3.28513e-13	3.56457e-13	1	1	0
ALOX5	240	broad.mit.edu	37	10	45939258	45939258	+	Silent	SNP	C	C	T	rs149908407		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:45939258C>T	ENST00000374391.2	+	12	1709	c.1656C>T	c.(1654-1656)gcC>gcT	p.A552A	ALOX5_ENST00000542434.1_Silent_p.A552A	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	552	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CCCAGCACGCCGCGGTCAACT	0.697000													3	7					0	0	1	0	0
TOP3A	7156	broad.mit.edu	37	17	18181522	18181522	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:18181522C>T	ENST00000321105.5	-	18	2508	c.2294G>A	c.(2293-2295)cGc>cAc	p.R765H	TOP3A_ENST00000542570.1_Missense_Mutation_p.R670H|TOP3A_ENST00000540524.1_Missense_Mutation_p.R295H	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	765					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						AGCCTGCAGGCGGCCAGAGGG	0.632000													11	55					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9878212	9878212	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:9878212T>C	ENST00000256190.8	-	19	2293	c.2156A>G	c.(2155-2157)gAg>gGg	p.E719G	RP11-1H15.2_ENST00000533659.1_RNA	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	719					myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GCGTAGTTGCTCAGCTGCCAG	0.453000													64	107					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	135988257	135988257	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:135988257G>A	ENST00000401392.1	-	13	1992	c.1780C>T	c.(1780-1782)Cca>Tca	p.P594S	ZRANB3_ENST00000264159.6_Missense_Mutation_p.P594S|ZRANB3_ENST00000412849.1_5'UTR|ZRANB3_ENST00000536680.1_Missense_Mutation_p.P594S			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	594						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		GACTGGGATGGTGTCTCTTCC	0.502000													25	40					0	0	1	0	0
PPP4R2	151987	broad.mit.edu	37	3	73096418	73096418	+	Silent	SNP	G	G	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:73096418G>A	ENST00000356692.5	+	3	451	c.198G>A	c.(196-198)gaG>gaA	p.E66E	PPP4R2_ENST00000295862.9_Silent_p.E10E|PPP4R2_ENST00000394284.3_Intron			Q9NY27	PP4R2_HUMAN	protein phosphatase 4, regulatory subunit 2	66					mRNA processing|protein modification process|regulation of double-strand break repair via homologous recombination|RNA splicing	centrosome|nucleus|protein phosphatase 4 complex	protein binding, bridging|protein phosphatase type 4 regulator activity			breast(2)|endometrium(1)|large_intestine(1)|lung(3)|skin(2)|stomach(1)|urinary_tract(2)	12		Prostate(10;0.0187)|Lung SC(41;0.236)		Epithelial(33;1.76e-07)|BRCA - Breast invasive adenocarcinoma(55;9.42e-05)|LUSC - Lung squamous cell carcinoma(21;0.00211)|Lung(16;0.00643)|KIRC - Kidney renal clear cell carcinoma(39;0.0164)|Kidney(39;0.0193)|OV - Ovarian serous cystadenocarcinoma(275;0.031)		CAGCTCCTGAGCCAAGAGGTC	0.358000													12	9					0	0	1	0	0
DEDD2	162989	broad.mit.edu	37	19	42713926	42713926	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:42713926C>T	ENST00000595337.1	-	4	602	c.515G>A	c.(514-516)cGg>cAg	p.R172Q	DEDD2_ENST00000336034.4_Missense_Mutation_p.R167Q|DEDD2_ENST00000598727.1_Missense_Mutation_p.R172Q|DEDD2_ENST00000593804.1_5'UTR|DEDD2_ENST00000596251.1_Missense_Mutation_p.R172Q	NM_001270614.1	NP_001257543.1	Q8WXF8	DEDD2_HUMAN	death effector domain containing 2	172					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity			endometrium(1)|large_intestine(1)|ovary(1)|prostate(2)	5		Prostate(69;0.0704)				GGCCCCTCTCCGCCGCCGTCT	0.657000													20	31					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66431994	66431994	+	Silent	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:66431994C>T	ENST00000341529.3	+	9	1618	c.1470C>T	c.(1468-1470)aaC>aaT	p.N490N	CDH5_ENST00000539168.1_5'UTR	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	490	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		TGTGTGAGAACGCTGTCCATG	0.562000													29	62					0	0	1	0	0
KLHL8	57563	broad.mit.edu	37	4	88085050	88085050	+	Silent	SNP	C	C	T	rs142229964		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:88085050C>T	ENST00000273963.5	-	9	2060	c.1719G>A	c.(1717-1719)gcG>gcA	p.A573A	KLHL8_ENST00000498875.2_Silent_p.A497A|KLHL8_ENST00000425278.2_Silent_p.A390A|KLHL8_ENST00000512111.1_Silent_p.A573A|KLHL8_ENST00000545252.1_Silent_p.A222A	NM_020803.3	NP_065854.3	Q9P2G9	KLHL8_HUMAN	kelch-like family member 8	573										breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)	17		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		CTGGATCAAACGCTTCTACTG	0.383000													55	90					0	0	1	0	0
PRMT1	0	broad.mit.edu	37	19	50191419	50191419	+	Splice_Site	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:50191419C>T	ENST00000532489.1	+	11	1401	c.894_splice	c.e11-1	p.R299_splice	PRMT1_ENST00000391851.4_Splice_Site_p.R327_splice|PRMT1_ENST00000527866.1_3'UTR|PRMT1_ENST00000454376.2_Splice_Site_p.R345_splice			Q8WUW5	Q8WUW5_HUMAN	protein arginine methyltransferase 1	326						cytoplasm	protein methyltransferase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(2)	12		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00103)|GBM - Glioblastoma multiforme(134;0.012)		CTCCCTGCAGCGGGACCTGGA	0.692000													24	49					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72923683	72923683	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:72923683T>C	ENST00000268489.5	-	4	4067	c.3395A>G	c.(3394-3396)gAc>gGc	p.D1132G	ZFHX3_ENST00000397992.5_Missense_Mutation_p.D218G	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1132					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CAGGTCCTCGTCCTCCTCTGG	0.637000													13	17					0	0	1	0	0
SYT15	83849	broad.mit.edu	37	10	46969394	46969394	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:46969394C>T	ENST00000374325.3	-	2	219	c.67G>A	c.(67-69)Ggg>Agg	p.G23R	SYT15_ENST00000374321.4_Missense_Mutation_p.G23R|SYT15_ENST00000503753.1_Missense_Mutation_p.G23R|SYT15_ENST00000374323.3_Intron	NM_181519.2	NP_852660.1	Q9BQS2	SYT15_HUMAN	synaptotagmin XV	23						integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						CAGCTTGCCCCGATCAACAGC	0.637000													12	49					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15496663	15496663	+	Missense_Mutation	SNP	G	G	A	rs142358716		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:15496663G>A	ENST00000341776.2	+	7	1451	c.1207G>A	c.(1207-1209)Gcc>Acc	p.A403T	JARID2_ENST00000397311.3_Missense_Mutation_p.A231T|JARID2_ENST00000541660.1_Missense_Mutation_p.A365T	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	403					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CACTGGGCCCGCCGTCAATGG	0.612000													24	28					0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155931685	155931685	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:155931685C>T	ENST00000368316.1	-	15	1621	c.1151G>A	c.(1150-1152)cGc>cAc	p.R384H	ARHGEF2_ENST00000361247.4_Missense_Mutation_p.R412H|ARHGEF2_ENST00000368315.3_Missense_Mutation_p.R413H|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.R411H|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.R384H			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	412	DH.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CAGGTCCTGGCGCTCCTCCTC	0.582000													17	42					0	0	1	0	0
RPS6	6194	broad.mit.edu	37	9	19376346	19376346	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:19376346C>T	ENST00000380394.4	-	6	753	c.695G>A	c.(694-696)cGc>cAc	p.R232H	RPS6_ENST00000498815.1_5'UTR|RPS6_ENST00000380384.1_Missense_Mutation_p.R201H|RPS6_ENST00000315377.4_Missense_Mutation_p.R201H	NM_001010.2	NP_001001.2	P62753	RS6_HUMAN	ribosomal protein S6	232					endocrine pancreas development|glucose homeostasis|insulin receptor signaling pathway|positive regulation of apoptosis|rRNA processing|TOR signaling cascade|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding	p.R232H(1)		endometrium(3)|lung(2)|ovary(1)|urinary_tract(1)	7		Colorectal(97;3.46e-05)|Myeloproliferative disorder(762;0.0255)		Lung(42;0.161)|LUSC - Lung squamous cell carcinoma(42;0.234)		GGAAAGTCTGCGTCTCTTCGC	0.398000													9	110					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39265208	39265208	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:39265208A>G	ENST00000280481.7	+	1	3943	c.3727A>G	c.(3727-3729)Ata>Gta	p.I1243V		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1243					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GAATCAGCTGATAAATGGCAC	0.443000													72	74					0	0	1	0	0
CLSTN1	22883	broad.mit.edu	37	1	9795233	9795233	+	Splice_Site	SNP	C	C	G	rs113333732		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:9795233C>G	ENST00000377298.4	-	14	2676		c.e14-1		CLSTN1_ENST00000377288.3_Splice_Site|CLSTN1_ENST00000361311.4_Splice_Site	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1						homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		GTTAAAACACCTGCCAGCAAG	0.587000													8	51					0	0	1	0	0
YWHAB	7529	broad.mit.edu	37	20	43530232	43530232	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:43530232C>T	ENST00000372839.3	+	3	332	c.58C>T	c.(58-60)Cga>Tga	p.R20*	YWHAB_ENST00000479421.1_3'UTR|YWHAB_ENST00000353703.4_Nonsense_Mutation_p.R20*	NM_003404.3	NP_003395.1	P31946	1433B_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	20					activation of MAPKK activity|activation of pro-apoptotic gene products|axon guidance|cytoplasmic sequestering of protein|epidermal growth factor receptor signaling pathway|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|mRNA metabolic process|negative regulation of protein dephosphorylation|nerve growth factor receptor signaling pathway|Ras protein signal transduction	centrosome|cytosol|melanosome|perinuclear region of cytoplasm	histone deacetylase binding|phosphoserine binding|protein domain specific binding			breast(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|urinary_tract(1)	12		Myeloproliferative disorder(115;0.0122)				GCAGGCTGAGCGATATGATGA	0.458000													28	37					0	0	1	0	0
ZMYM6	9204	broad.mit.edu	37	1	35484911	35484912	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:35484911_35484912insA	ENST00000317538.5	-	4	634_635	c.470_471insT	c.(469-471)tgtfs	p.C157fs	ZMYM6_ENST00000487874.1_Intron|ZMYM6_ENST00000373340.2_Intron|ZMYM6_ENST00000357182.4_Intron|ZMYM6_ENST00000493328.1_Intron|ZMYM6_ENST00000373333.1_Frame_Shift_Ins_p.C157fs			O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	0					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				ATATACACACTAAAAAAAAGGT	0.342													22	26	---	---	---	---					
CYP4A11	1579	broad.mit.edu	37	1	47395847	47395848	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:47395847_47395848insT	ENST00000310638.4	-	12	1530_1531	c.1499_1500insA	c.(1498-1500)aggfs	p.R500fs	CYP4A11_ENST00000371904.4_Frame_Shift_Ins_p.R501fs|CYP4A11_ENST00000475477.1_5'UTR	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	500			NGIHLRLRRLPNPCEDKDQL -> MESTCVSGGSLTLVKTR TSFEGLHLPSCLPDPRFCPLPVCPYPVFCLPTFPSSHLPAV PQSACPSLSHLSPGLPTCLSTCLLPTCISCWEKS (in CYP4A11V).		long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	GGTGGATTCCATTTTTGGATTT	0.589													12	32	---	---	---	---					
USP33	23032	broad.mit.edu	37	1	78184290	78184291	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:78184290_78184291insT	ENST00000370793.1	-	17	2166_2167	c.1820_1821insA	c.(1819-1821)attfs	p.I607fs	USP33_ENST00000357428.1_Frame_Shift_Ins_p.I607fs|USP33_ENST00000370792.3_Frame_Shift_Ins_p.I599fs|USP33_ENST00000370794.3_Frame_Shift_Ins_p.I576fs	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	607					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						CCTCAGGAAAGTTTTGTACTTT	0.282													13	77	---	---	---	---					
GBP1P1	0	broad.mit.edu	37	1	89887193	89887193	+	RNA	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:89887193delT	ENST00000513638.1	+	0	557					NR_003133.2																						AATGGAGGACTTTTTTTTATT	0.318													2	4	---	---	---	---					
LPPR5	0	broad.mit.edu	37	1	99422227	99422228	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:99422227_99422228insT	ENST00000370188.3	-	2	667_668	c.307_308insA	c.(307-309)tatfs	p.Y103fs	LPPR5_ENST00000263177.4_Frame_Shift_Ins_p.Y103fs	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		103						integral to membrane	hydrolase activity										AGTTAAAATAGTTTTTTCCTGG	0.337													21	31	---	---	---	---					
OR10X1	128367	broad.mit.edu	37	1	158548712	158548712	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:158548712delT	ENST00000368150.1	-	1	977	c.978delA	c.(976-978)aafs	p.K326fs		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	326					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					CCCAAGATTATTTTTTCAAGG	0.423													57	104	---	---	---	---					
PLA2G4A	5321	broad.mit.edu	37	1	186934587	186934588	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:186934587_186934588insA	ENST00000367466.3	+	15	1778_1779	c.1626_1627insA	c.(1624-1629)agaaaafs	p.RK542fs	PLA2G4A_ENST00000442353.2_Frame_Shift_Ins_p.RK482fs	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	542	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	ATGTCAAAAGTAAAAAGATTCA	0.361													25	43	---	---	---	---					
LYST	1130	broad.mit.edu	37	1	235964219	235964220	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:235964219_235964220insA	ENST00000389794.3	-	9	4064_4065	c.3890_3891insT	c.(3889-3891)taafs	p.*1297fs	LYST_ENST00000389793.2_Frame_Shift_Ins_p.*1297fs|LYST_ENST00000536965.1_Frame_Shift_Ins_p.*1297fs			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1297					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TAATAATTTTCAAAAAACTCTC	0.322													28	37	---	---	---	---					
PGBD2	0	broad.mit.edu	37	1	249211828	249211828	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr1:249211828delT	ENST00000355360.4	+	3	562	c.292delT	c.(292-294)ttfs	p.F99fs	PGBD2_ENST00000329291.5_Frame_Shift_Del_p.F350fs|PGBD2_ENST00000539153.1_Frame_Shift_Del_p.F347fs	NM_001017434.1	NP_001017434.1	Q6P3X8	PGBD2_HUMAN	piggyBac transposable element derived 2	350										NS(1)|endometrium(3)|lung(6)|ovary(1)|skin(3)	14	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ATATCACATATTTTTTGACAA	0.438													54	80	---	---	---	---					
MYCN	4613	broad.mit.edu	37	2	16085913	16085913	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:16085913delC	ENST00000281043.3	+	3	1386	c.1089delC	c.(1087-1089)atfs	p.I363fs		NM_005378.4	NP_005369.2	P04198	MYCN_HUMAN	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog	363				I -> V (in Ref. 3; CAA68678).	regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			AGAGTGTCATCCCCCCAAAGG	0.602			A		neuroblastoma								15	22	---	---	---	---					
CAD	790	broad.mit.edu	37	2	27456982	27456982	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:27456982delC	ENST00000264705.4	+	22	3668	c.3506delC	c.(3505-3507)acfs	p.T1169fs	CAD_ENST00000403525.1_Frame_Shift_Del_p.T1106fs	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1169	ATP-grasp 2.|CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	ACGCTGGTGACCCCCCCACAA	0.577													23	27	---	---	---	---					
MSH6	2956	broad.mit.edu	37	2	48026866	48026866	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:48026866delT	ENST00000234420.4	+	4	1896	c.1744delT	c.(1744-1746)ttfs	p.F582fs	MSH6_ENST00000540021.1_Frame_Shift_Del_p.F452fs|MSH6_ENST00000538136.1_Frame_Shift_Del_p.F280fs|FBXO11_ENST00000405808.1_Intron	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	582					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTGTTCGAGATTTAGGACTCT	0.388			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				72	115	---	---	---	---					
VPS54	51542	broad.mit.edu	37	2	64120618	64120618	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:64120618delT	ENST00000354504.3	-	20	3010	c.2421delA	c.(2419-2421)aafs	p.K807fs	VPS54_ENST00000409558.3_Frame_Shift_Del_p.K948fs|VPS54_ENST00000272322.4_Frame_Shift_Del_p.K960fs			Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 homolog (S. cerevisiae)	960					protein transport|retrograde transport, endosome to Golgi					endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						CTTTAAGGCCTTTTAAGGCTT	0.373													48	94	---	---	---	---					
MAP4K4	9448	broad.mit.edu	37	2	102452432	102452432	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:102452432delA	ENST00000413150.2	+	9	820	c.765delA	c.(763-765)tcfs	p.S255fs	MAP4K4_ENST00000302217.5_Intron|MAP4K4_ENST00000350198.4_Frame_Shift_Del_p.S255fs|MAP4K4_ENST00000350878.4_Frame_Shift_Del_p.S235fs|MAP4K4_ENST00000324219.4_Frame_Shift_Del_p.S255fs|MAP4K4_ENST00000425019.1_Frame_Shift_Del_p.S255fs|MAP4K4_ENST00000347699.4_Frame_Shift_Del_p.S255fs|MAP4K4_ENST00000456652.1_Intron	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	255	Protein kinase.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GGCTGAAGTCAAAAAAATGGT	0.413													7	8	---	---	---	---					
RGPD3	653489	broad.mit.edu	37	2	107041595	107041595	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:107041595delT	ENST00000409886.3	-	20	2915	c.2828delA	c.(2827-2829)atfs	p.N943fs	RGPD3_ENST00000304514.7_Frame_Shift_Del_p.N943fs	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	943					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						GCCAGTATCATTTTCAAGAGG	0.418													24	507	---	---	---	---					
RGPD8	727851	broad.mit.edu	37	2	113147697	113147697	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:113147697delT	ENST00000302558.3	-	20	3016	c.2825delA	c.(2824-2826)atfs	p.N942fs	RGPD8_ENST00000409750.1_Frame_Shift_Del_p.N802fs	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8											endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GCCAGTATCATTTTCAAGAGG	0.428													16	474	---	---	---	---					
CCDC148	130940	broad.mit.edu	37	2	159077216	159077217	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:159077216_159077217insT	ENST00000283233.5	-	11	1573_1574	c.1260_1261insA	c.(1258-1263)aaactgfs	p.L421fs	CCDC148-AS1_ENST00000412781.2_RNA|CCDC148_ENST00000409187.1_Frame_Shift_Ins_p.L430fs	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	421	Glu/Lys-rich.							p.K420fs*15(1)		endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						TTGGCCCAGTATTTTTTTATCT	0.317													15	24	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179549439	179549440	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:179549439_179549440insT	ENST00000589042.1	-	131	32815_32816	c.32591_32592insA	c.(32590-32592)agtfs	p.S10864fs	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Frame_Shift_Ins_p.S10547fs|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Frame_Shift_Ins_p.S9620fs	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10547	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGAGGAACCTTTTTTTCTGG	0.411													34	40	---	---	---	---					
PMS1	0	broad.mit.edu	37	2	190728676	190728678	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190728676_190728678delAAG	ENST00000441310.2	+	10	2297_2299	c.2064_2066delAAG	c.(2062-2067)aaa>aa	p.KR688del	PMS1_ENST00000447232.2_Intron|PMS1_ENST00000418224.3_In_Frame_Del_p.KR512del|PMS1_ENST00000421722.1_3'UTR|PMS1_ENST00000432292.3_In_Frame_Del_p.KR512del|PMS1_ENST00000409823.3_In_Frame_Del_p.KR649del	NM_000534.4	NP_000525.1	P54277	PMS1_HUMAN	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	688					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			AAATTGAAAAAAGAAGGAGTCAA	0.330			"""Mis, N"""			"""colorectal, endometrial, ovarian"""		Direct reversal of damage;Mismatch excision repair (MMR)					32	60	---	---	---	---					
MSTN	2660	broad.mit.edu	37	2	190922151	190922152	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:190922151_190922152insT	ENST00000260950.4	-	3	1092_1093	c.960_961insA	c.(958-963)aaatccfs	p.S321fs	C2orf88_ENST00000478197.1_Intron	NM_005259.2	NP_005250.1	O14793	GDF8_HUMAN	myostatin	321					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)	12			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			GTATGAGGATATTTTTGTAAAA	0.391													19	43	---	---	---	---					
BZW1	9689	broad.mit.edu	37	2	201683504	201683505	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:201683504_201683505insA	ENST00000409600.1	+	9	1301_1302	c.846_847insA	c.(844-849)ataaaafs	p.IK282fs	BZW1_ENST00000452790.2_Frame_Shift_Ins_p.IK314fs|BZW1_ENST00000409226.1_Frame_Shift_Ins_p.IK286fs	NM_001207067.1|NM_014670.3	NP_001193996.1|NP_055485.2	Q7L1Q6	BZW1_HUMAN	basic leucine zipper and W2 domains 1	282	W2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	protein binding			breast(1)|kidney(2)|large_intestine(1)|lung(2)	6						AGGAGGAGATGAAAAAAAACAA	0.371													15	28	---	---	---	---					
CARF	79800	broad.mit.edu	37	2	203839141	203839141	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:203839141delA	ENST00000320443.8	+	12	2459	c.1416delA	c.(1414-1416)atfs	p.I472fs	CARF_ENST00000428585.1_Frame_Shift_Del_p.I396fs|CARF_ENST00000402905.2_Frame_Shift_Del_p.I472fs|CARF_ENST00000414439.1_Frame_Shift_Del_p.I370fs|CARF_ENST00000545262.1_Frame_Shift_Del_p.I396fs|WDR12_ENST00000477723.1_Intron|CARF_ENST00000545253.1_Frame_Shift_Del_p.I384fs|CARF_ENST00000438828.2_Frame_Shift_Del_p.I472fs					calcium responsive transcription factor																		TAAATGATATAAAAAATCACA	0.333													9	48	---	---	---	---					
CCDC108	255101	broad.mit.edu	37	2	219892686	219892687	+	Frame_Shift_Ins	INS	-	-	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr2:219892686_219892687insG	ENST00000341552.5	-	13	1979_1980	c.1896_1897insC	c.(1894-1899)cctgacfs	p.D633fs	CCDC108_ENST00000453220.1_Frame_Shift_Ins_p.D633fs|CCDC108_ENST00000441968.1_Frame_Shift_Ins_p.D633fs|CCDC108_ENST00000410037.1_Frame_Shift_Ins_p.D568fs|CCDC108_ENST00000409865.3_Frame_Shift_Ins_p.D622fs	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	633						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AACTCGGTCATGGGGGGGATAT	0.599													34	54	---	---	---	---					
CNTN6	27255	broad.mit.edu	37	3	1371501	1371501	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:1371501delA	ENST00000446702.2	+	11	1873	c.1246delA	c.(1246-1248)aafs	p.K418fs	CNTN6_ENST00000539053.1_Frame_Shift_Del_p.K346fs|CNTN6_ENST00000350110.2_Frame_Shift_Del_p.K418fs			Q9UQ52	CNTN6_HUMAN	contactin 6	418	Ig-like C2-type 5.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane		p.K418fs*63(1)		breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAGTCCAGTTAAAAAAAAGTC	0.393													27	63	---	---	---	---					
HSPD1P6	0	broad.mit.edu	37	3	36810381	36810381	+	RNA	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:36810381delT	ENST00000424886.1	-	0	405																											GAGTGAGGCCttttttttttt	0.542													3	3	---	---	---	---					
NXPE3	91775	broad.mit.edu	37	3	101525972	101525973	+	Splice_Site	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:101525972_101525973insA	ENST00000422132.1	+	3	1119		c.e3+2		NXPE3_ENST00000491511.1_Splice_Site|NXPE3_ENST00000477909.1_Splice_Site|NXPE3_ENST00000273347.5_Splice_Site					neurexophilin and PC-esterase domain family, member 3																		GAATAAAAGGTAAAAAAAAGAA	0.351													26	25	---	---	---	---					
POLQ	10721	broad.mit.edu	37	3	121208979	121208979	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:121208979delT	ENST00000264233.5	-	16	2927	c.2799delA	c.(2797-2799)aafs	p.K933fs		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	933					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TTGATGTTAATTTTTTATAAG	0.308								DNA polymerases (catalytic subunits)					24	34	---	---	---	---					
MFN1	55669	broad.mit.edu	37	3	179069813	179069813	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:179069813delT	ENST00000471841.1	+	3	364	c.238delT	c.(238-240)ttfs	p.F81fs	MFN1_ENST00000263969.5_Frame_Shift_Del_p.F81fs|MFN1_ENST00000280653.7_Frame_Shift_Del_p.F81fs	NM_033540.2	NP_284941.2	Q8IWA4	MFN1_HUMAN	mitofusin 1	81					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			GAAGGTGGCATTTTTTGGCAG	0.388													45	92	---	---	---	---					
TTC14	151613	broad.mit.edu	37	3	180323592	180323593	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr3:180323592_180323593insA	ENST00000412756.2	+	7	965_966	c.896_897insA	c.(895-897)aaafs	p.K299fs	TTC14_ENST00000296015.4_Frame_Shift_Ins_p.K299fs|TTC14_ENST00000382584.4_Frame_Shift_Ins_p.K299fs	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	299							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TCTGCATTGAGAAAAAAACAAT	0.292													34	82	---	---	---	---					
RBPJ	3516	broad.mit.edu	37	4	26417146	26417146	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:26417146delA	ENST00000342320.4	+	4	378	c.202delA	c.(202-204)aafs	p.K70fs	RBPJ_ENST00000361572.6_Frame_Shift_Del_p.K84fs|RBPJ_ENST00000504907.1_Frame_Shift_Del_p.K70fs|RBPJ_ENST00000348160.4_Frame_Shift_Del_p.K71fs|RBPJ_ENST00000511401.1_3'UTR|RBPJ_ENST00000507561.1_Frame_Shift_Del_p.K49fs|RBPJ_ENST00000342295.1_Frame_Shift_Del_p.K84fs|RBPJ_ENST00000355476.3_Frame_Shift_Del_p.K70fs|RBPJ_ENST00000345843.3_Frame_Shift_Del_p.K69fs			Q06330	SUH_HUMAN	recombination signal binding protein for immunoglobulin kappa J region	84					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)	15		Breast(46;0.0503)				TGGATGGAAGAAAAAAAAAGA	0.373													15	112	---	---	---	---					
TBC1D19	55296	broad.mit.edu	37	4	26638843	26638843	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:26638843delA	ENST00000264866.4	+	5	583	c.305delA	c.(304-306)gafs	p.E102fs	TBC1D19_ENST00000515568.1_3'UTR|TBC1D19_ENST00000511789.1_Frame_Shift_Del_p.E37fs	NM_018317.2	NP_060787.2	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	102						intracellular	Rab GTPase activator activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	17		Breast(46;0.0503)				GGAAGTTGGGAAAAAAGAATT	0.259													18	35	---	---	---	---					
KDR	3791	broad.mit.edu	37	4	55979611	55979612	+	Frame_Shift_Ins	INS	-	-	T	rs66495429		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:55979611_55979612insT	ENST00000263923.4	-	7	1130_1131	c.835_836insA	c.(835-837)ccafs	p.P279fs		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	279	Ig-like C2-type 3.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCCAGACTGGGTTTTTAGGTCT	0.416			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			20	45	---	---	---	---					
EXOC1	55763	broad.mit.edu	37	4	56724596	56724597	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:56724596_56724597insT	ENST00000381295.2	+	2	455_456	c.107_108insT	c.(106-108)tttfs	p.F36fs	EXOC1_ENST00000346134.7_Frame_Shift_Ins_p.F36fs|EXOC1_ENST00000349598.6_Frame_Shift_Ins_p.F36fs	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	36					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					AAAAAGAACTGTTTTTTATGTG	0.337													30	52	---	---	---	---					
PPP3CA	5530	broad.mit.edu	37	4	102001725	102001725	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr4:102001725delA	ENST00000394854.3	-	8	1602	c.919delT	c.(919-921)cafs	p.S307fs	PPP3CA_ENST00000512215.1_Intron|PPP3CA_ENST00000523694.2_Frame_Shift_Del_p.S240fs|PPP3CA_ENST00000323055.6_Frame_Shift_Del_p.S307fs|PPP3CA_ENST00000394853.4_Frame_Shift_Del_p.S307fs|PPP3CA_ENST00000507176.1_Frame_Shift_Del_p.S209fs	NM_000944.4	NP_000935.1	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha isozyme	307					protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		TTTGGTGCTGAAAAAATTGTA	0.318													30	46	---	---	---	---					
SDHAP3	0	broad.mit.edu	37	5	1589289	1589290	+	RNA	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:1589289_1589290insA	ENST00000436493.2	-	0	588_589																											gatctagttttaaaaaaacaaa	0.525													10	22	---	---	---	---					
KIAA0947	23379	broad.mit.edu	37	5	5461107	5461107	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:5461107delA	ENST00000296564.7	+	13	1882	c.1660delA	c.(1660-1662)aafs	p.K554fs		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	554								p.K554E(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						CGTATTGTCTAAAATGATGGG	0.433													78	103	---	---	---	---					
FYB	2533	broad.mit.edu	37	5	39202090	39202091	+	Frame_Shift_Ins	INS	-	-	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr5:39202090_39202091insC	ENST00000351578.6	-	2	1162_1163	c.972_973insG	c.(970-975)ggcatgfs	p.M325fs	FYB_ENST00000540520.1_Frame_Shift_Ins_p.M335fs|FYB_ENST00000512982.1_Frame_Shift_Ins_p.M325fs|FYB_ENST00000515010.1_Frame_Shift_Ins_p.M325fs|FYB_ENST00000505428.1_Frame_Shift_Ins_p.M325fs	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	325					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding	p.P325A(3)|p.P335A(1)		endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			TGGCCCCATGGCCCCCCCACTG	0.540													19	46	---	---	---	---					
HIVEP1	3096	broad.mit.edu	37	6	12125469	12125469	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:12125469delA	ENST00000379388.2	+	4	5773	c.5441delA	c.(5440-5442)gafs	p.E1814fs		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1814					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GTGATGTTGGAAAAGGATGTT	0.383													22	125	---	---	---	---					
C6orf15	29113	broad.mit.edu	37	6	31079568	31079568	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:31079568delT	ENST00000259870.3	-	2	571	c.568delA	c.(568-570)tcfs	p.I190fs		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	190										endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						TGGGAAAGGATTTTTCCCCCG	0.617													13	28	---	---	---	---					
TTK	7272	broad.mit.edu	37	6	80751910	80751910	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:80751910delA	ENST00000509894.1	+	22	3391	c.2562delA	c.(2560-2562)ggfs	p.G854fs	TTK_ENST00000369798.2_Frame_Shift_Del_p.G855fs|TTK_ENST00000230510.3_Frame_Shift_Del_p.G854fs			P33981	TTK_HUMAN	TTK protein kinase	855					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.G839G(1)|p.K841fs?(1)|p.G855G(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		AAAAAAGGGGAAAAAAATGAT	0.308													21	70	---	---	---	---					
FAM26E	254228	broad.mit.edu	37	6	116836953	116836954	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:116836953_116836954insT	ENST00000368599.3	+	2	782_783	c.731_732insT	c.(730-732)tttfs	p.F244fs	TRAPPC3L_ENST00000368602.3_Intron	NM_153711.2	NP_714922.1	Q8N5C1	FA26E_HUMAN	family with sequence similarity 26, member E	244						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7		all_cancers(87;0.0608)|all_epithelial(87;0.05)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0242)|all cancers(137;0.0419)|OV - Ovarian serous cystadenocarcinoma(136;0.0671)|Epithelial(106;0.212)		AACCTGAAATGTTTTTTTGAAA	0.460													13	68	---	---	---	---					
AHI1	54806	broad.mit.edu	37	6	135784283	135784284	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:135784283_135784284insT	ENST00000367800.4	-	6	1126_1127	c.910_911insA	c.(910-912)aaafs	p.K304fs	AHI1_ENST00000457866.2_Frame_Shift_Ins_p.K304fs|AHI1_ENST00000327035.6_Frame_Shift_Ins_p.K304fs	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	304						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		CTTCTTTTTTGTTTTTTTTGGT	0.307													12	56	---	---	---	---					
PHACTR2	9749	broad.mit.edu	37	6	144086413	144086414	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr6:144086413_144086414insA	ENST00000427704.2	+	6	807_808	c.677_678insA	c.(676-678)taafs	p.*226fs	PHACTR2_ENST00000367584.4_Frame_Shift_Ins_p.*214fs|PHACTR2_ENST00000305766.6_Frame_Shift_Ins_p.*146fs|PHACTR2_ENST00000440869.2_Frame_Shift_Ins_p.*237fs|PHACTR2_ENST00000367582.3_Frame_Shift_Ins_p.*157fs	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	226							actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TCCTCTCATTCAAAAAAAACAA	0.396													24	102	---	---	---	---					
C7orf57	136288	broad.mit.edu	37	7	48086204	48086205	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:48086204_48086205insA	ENST00000348904.3	+	5	710_711	c.498_499insA	c.(496-501)gaaaaafs	p.EK166fs	C7orf57_ENST00000435376.1_Frame_Shift_Ins_p.EK44fs|C7orf57_ENST00000430738.1_Frame_Shift_Ins_p.EK211fs|C7orf57_ENST00000539619.1_Frame_Shift_Ins_p.EK166fs|C7orf57_ENST00000420324.1_Frame_Shift_Ins_p.EK211fs	NM_001100159.2	NP_001093629.1	Q8NEG2	CG057_HUMAN	chromosome 7 open reading frame 57	166										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	9						TTGAAAAGGAGAAAAAAAAGGT	0.495													6	8	---	---	---	---					
FIGNL1	63979	broad.mit.edu	37	7	50514009	50514009	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:50514009delT	ENST00000419119.1	-	2	2530	c.977delA	c.(976-978)agfs	p.K326fs	FIGNL1_ENST00000356889.4_Frame_Shift_Del_p.K326fs|FIGNL1_ENST00000433017.1_Frame_Shift_Del_p.K326fs|FIGNL1_ENST00000395556.2_Frame_Shift_Del_p.K326fs			Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	326					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				TCCTAGAGACTTTTTTACACC	0.433													23	42	---	---	---	---					
GTF2IRD2P1	0	broad.mit.edu	37	7	72657208	72657208	+	RNA	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:72657208delA	ENST00000425256.1	-	0	2703					NR_002164.1																						ctcaaaaaagaaaaaaaaatt	0.507													18	19	---	---	---	---					
AKAP9	10142	broad.mit.edu	37	7	91709345	91709345	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:91709345delA	ENST00000359028.2	+	32	8159	c.7934delA	c.(7933-7935)gafs	p.E2645fs	AKAP9_ENST00000356239.3_Frame_Shift_Del_p.E2633fs|AKAP9_ENST00000358100.2_Frame_Shift_Del_p.E2645fs			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2645	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAAATTGCAGAAAAAAATGTT	0.323			T	BRAF	papillary thyroid								20	36	---	---	---	---					
BCAP29	55973	broad.mit.edu	37	7	107234540	107234540	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:107234540delT	ENST00000379119.2	+	3	348	c.334delT	c.(334-336)ttfs	p.F113fs	BCAP29_ENST00000465919.1_Frame_Shift_Del_p.F19fs|BCAP29_ENST00000005259.4_Frame_Shift_Del_p.F113fs|BCAP29_ENST00000379121.2_Frame_Shift_Del_p.F19fs|BCAP29_ENST00000379117.2_Frame_Shift_Del_p.F113fs|BCAP29_ENST00000494086.1_3'UTR|BCAP29_ENST00000445771.2_Frame_Shift_Del_p.F113fs	NM_001008405.2	NP_001008405.1	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein 29	113					apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane		p.W114fs*2(2)		cervix(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	14						ATTTTCCCTATTTTTTTGGCT	0.328													17	26	---	---	---	---					
RP11-274B21.1	0	broad.mit.edu	37	7	128255832	128255833	+	RNA	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:128255832_128255833insT	ENST00000605862.1	+	0	758																											TATAGAAATGATTTTTTTTTTC	0.282													3	5	---	---	---	---					
JHDM1D	0	broad.mit.edu	37	7	139838977	139838977	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:139838977delC	ENST00000397560.2	-	2	305	c.208delG	c.(208-210)aafs	p.E71fs	JHDM1D_ENST00000006967.5_Frame_Shift_Del_p.E71fs	NM_030647.1	NP_085150.1	Q6ZMT4	KDM7_HUMAN		71					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)	22	Melanoma(164;0.0142)					TGATGTTCTTCTACTCCAACA	0.363													38	85	---	---	---	---					
NOM1	64434	broad.mit.edu	37	7	156752697	156752698	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr7:156752697_156752698insA	ENST00000275820.3	+	4	1476_1477	c.1461_1462insA	c.(1459-1464)ttaaaafs	p.LK487fs	NOM1_ENST00000460332.1_3'UTR	NM_138400.1	NP_612409.1	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	487	MIF4G.				RNA metabolic process	nucleolus	protein binding			endometrium(5)|kidney(4)|large_intestine(9)|lung(7)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		TCGACATTTTGAAAAAACTGAT	0.391													24	43	---	---	---	---					
CHRNA6	8973	broad.mit.edu	37	8	42611574	42611574	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:42611574delA	ENST00000276410.2	-	5	1123	c.768delT	c.(766-768)ttfs	p.F256fs	CHRNA6_ENST00000534622.1_Frame_Shift_Del_p.F241fs	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	256						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			ACACGGTTAGAAATGAAATAA	0.378													20	27	---	---	---	---					
IL7	3574	broad.mit.edu	37	8	79652263	79652264	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr8:79652263_79652264insA	ENST00000263851.4	-	3	801_802	c.201_202insT	c.(199-204)ttaaagfs	p.L67fs	IL7_ENST00000519833.1_5'UTR|IL7_ENST00000541183.1_Frame_Shift_Ins_p.L16fs|IL7_ENST00000520269.1_Frame_Shift_Ins_p.L67fs	NM_000880.3|NM_001199886.1|NM_001199887.1	NP_000871.1|NP_001186815.1|NP_001186816.1	P13232	IL7_HUMAN	interleukin 7	67					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding			endometrium(2)|large_intestine(2)|lung(1)	5						ATATGTCTTTTAAAAAAGTTAA	0.277													14	88	---	---	---	---					
DDX58	23586	broad.mit.edu	37	9	32488832	32488833	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:32488832_32488833insT	ENST00000379882.1	-	6	874_875	c.717_718insA	c.(715-720)aatcccfs	p.NP239fs	DDX58_ENST00000542096.1_Frame_Shift_Ins_p.NP213fs|DDX58_ENST00000545044.1_Frame_Shift_Ins_p.NP81fs|DDX58_ENST00000379868.1_Frame_Shift_Ins_p.NP81fs|DDX58_ENST00000379883.2_Frame_Shift_Ins_p.NP284fs			O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	284					detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		CCTTGTGGGAATTTTTTAAGAT	0.327													23	47	---	---	---	---					
ZCCHC7	84186	broad.mit.edu	37	9	37304288	37304289	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:37304288_37304289insA	ENST00000336755.5	+	4	864_865	c.758_759insA	c.(757-759)taafs	p.*253fs	ZCCHC7_ENST00000461038.1_3'UTR|ZCCHC7_ENST00000534928.1_5'UTR	NM_032226.2	NP_115602.2	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	253							nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	30				GBM - Glioblastoma multiforme(29;0.0137)		GGTCATTTATCAAAAAACTGCC	0.431													38	69	---	---	---	---					
CNTNAP3B	728577	broad.mit.edu	37	9	43815972	43815973	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:43815972_43815973insT	ENST00000377564.3	+	5	1119_1120	c.726_727insT	c.(724-729)gtttttfs	p.VF242fs	CNTNAP3B_ENST00000276974.6_Frame_Shift_Ins_p.VF242fs	NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	242	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						GAAAGCTTGTCTTTTTTCTTAA	0.302													13	92	---	---	---	---					
PTGR1	22949	broad.mit.edu	37	9	114359602	114359602	+	Translation_Start_Site	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:114359602delT	ENST00000238248.3	-	0	363				PTGR1_ENST00000309195.5_Frame_Shift_Del_p.N34fs|PTGR1_ENST00000538962.1_Frame_Shift_Del_p.N34fs|PTGR1_ENST00000407693.2_Frame_Shift_Del_p.N34fs			Q14914	PTGR1_HUMAN	prostaglandin reductase 1						leukotriene metabolic process	cytoplasm	15-oxoprostaglandin 13-oxidase activity|2-alkenal reductase activity|alcohol dehydrogenase (NAD) activity|zinc ion binding			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)	11						CTTACCTCCATTTTTTAAGGG	0.398													20	25	---	---	---	---					
DBC1	0	broad.mit.edu	37	9	121971078	121971078	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:121971078delT	ENST00000265922.3	-	7	1525	c.1064delA	c.(1063-1065)agfs	p.K355fs	DBC1_ENST00000482797.1_5'UTR	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		355					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GCGTTGGATCTTTTGTCTCTG	0.572													9	43	---	---	---	---					
SLC25A25	114789	broad.mit.edu	37	9	130854244	130854244	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:130854244delC	ENST00000373066.5	+	1	502	c.95delC	c.(94-96)acfs	p.T32fs	RP11-379C10.4_ENST00000453870.1_RNA|SLC25A25_ENST00000432073.2_Frame_Shift_Del_p.T32fs|SLC25A25_ENST00000373068.2_Intron|SLC25A25_ENST00000373069.5_Intron	NM_001265614.2	NP_001252543.1	Q6KCM7	SCMC2_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	0					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)	10						GTCAGAGGCACCCCAGCCCCT	0.577													30	80	---	---	---	---					
EHMT1	79813	broad.mit.edu	37	9	140707502	140707502	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr9:140707502delA	ENST00000460843.1	+	20	2939	c.2912delA	c.(2911-2913)gafs	p.E971fs		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	971					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		AAGAACAAGGAAGGAGAGACG	0.512													8	130	---	---	---	---					
KIN	22944	broad.mit.edu	37	10	7820854	7820854	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:7820854delT	ENST00000379562.3	-	5	552	c.505delA	c.(505-507)ctfs	p.T169fs	KIN_ENST00000535925.1_Frame_Shift_Del_p.T169fs|KIN_ENST00000543003.1_Frame_Shift_Del_p.T63fs			O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)	169					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						AATTTGGCAGTTTTTTCTTCA	0.458													74	130	---	---	---	---					
UPF2	26019	broad.mit.edu	37	10	12077380	12077381	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:12077380_12077381insT	ENST00000356352.2	-	1	515_516	c.42_43insA	c.(40-45)aaactcfs	p.L15fs	UPF2_ENST00000397053.2_Frame_Shift_Ins_p.L15fs|UPF2_ENST00000460569.1_5'UTR|UPF2_ENST00000357604.5_Frame_Shift_Ins_p.L15fs			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	15	Glu/Lys-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding	p.D15Y(1)		breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				GGTAAAGAGTCTTTTTCTTCCA	0.455													34	80	---	---	---	---					
ARHGAP21	57584	broad.mit.edu	37	10	24889778	24889778	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:24889778delT	ENST00000396432.2	-	14	3415	c.2929delA	c.(2929-2931)gafs	p.R977fs	ARHGAP21_ENST00000493154.1_Intron|ARHGAP21_ENST00000320481.6_Frame_Shift_Del_p.R764fs	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	976	Interaction with ARF1 and ARF6.|PH.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GTCTGCTCTCTTTTATCTTTG	0.448													9	93	---	---	---	---					
ANKRD26	22852	broad.mit.edu	37	10	27329038	27329038	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:27329038delT	ENST00000376087.4	-	21	2396	c.2231delA	c.(2230-2232)atfs	p.N744fs	ANKRD26_ENST00000436985.2_Frame_Shift_Del_p.N760fs|ANKRD26_ENST00000376070.3_Frame_Shift_Del_p.N301fs	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	743						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						TTCACAGTGATTTTTTTTAAG	0.294													24	24	---	---	---	---					
TET1	80312	broad.mit.edu	37	10	70332152	70332153	+	Frame_Shift_Ins	INS	-	-	A	rs77014514		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:70332152_70332153insA	ENST00000373644.4	+	2	266_267	c.57_58insA	c.(55-60)aaaaaafs	p.KK19fs		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	19					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						AAGATGTAAACAAAAAAAAGAA	0.416													13	18	---	---	---	---					
ARHGAP19-SLIT1	0	broad.mit.edu	37	10	99019159	99019160	+	Splice_Site	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99019159_99019160insT	ENST00000453547.2	-	5	838_839	c.840_splice	c.e5+1	p.S280_splice	ARHGAP19_ENST00000371027.1_Splice_Site_p.S271_splice|ARHGAP19_ENST00000358531.4_Splice_Site_p.S280_splice|ARHGAP19-SLIT1_ENST00000358308.3_Splice_Site_p.S280_splice|ARHGAP19-SLIT1_ENST00000316676.8_Splice_Site_p.S280_splice|ARHGAP19_ENST00000355366.5_Splice_Site_p.S271_splice																							CAACACTCACATTTTTTGGCCA	0.450													28	72	---	---	---	---					
R3HCC1L	27291	broad.mit.edu	37	10	99969296	99969296	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:99969296delA	ENST00000298999.3	+	5	1728	c.1425delA	c.(1423-1425)atfs	p.I475fs	R3HCC1L_ENST00000314594.5_5'UTR|R3HCC1L_ENST00000370584.3_Frame_Shift_Del_p.I475fs|R3HCC1L_ENST00000370586.2_Intron	NM_014472.4	NP_055287.4			R3H domain and coiled-coil containing 1-like																		CCTTACCTATAAAAAAGATTG	0.378													16	44	---	---	---	---					
CCDC172	374355	broad.mit.edu	37	10	118100254	118100255	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr10:118100254_118100255insT	ENST00000333254.3	+	4	425_426	c.174_175insT	c.(172-177)cattttfs	p.HF58fs	CCDC172_ENST00000497093.1_Intron	NM_198515.2	NP_940917.1			coiled-coil domain containing 172																		AGGTTCAACAGTTTTTTGAAAA	0.287													33	65	---	---	---	---					
TMEM41B	440026	broad.mit.edu	37	11	9304992	9304992	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:9304992delT	ENST00000528080.1	-	7	1193	c.855delA	c.(853-855)aafs	p.K285fs		NM_015012.3	NP_055827.1	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B	285						integral to membrane				kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(2)	7				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		TCTGCTTTAGTTTTTTTTGGA	0.338													8	30	---	---	---	---					
PRG3	10394	broad.mit.edu	37	11	57147265	57147266	+	Frame_Shift_Ins	INS	-	-	G			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr11:57147265_57147266insG	ENST00000287143.2	-	3	185_186	c.76_77insC	c.(76-78)tctfs	p.S26fs		NM_006093.3	NP_006084.2	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3	26					basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding			large_intestine(3)|lung(5)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	13						GCTCTCCAGATGGGGGGCATCA	0.554													10	53	---	---	---	---					
KDM5A	5927	broad.mit.edu	37	12	443455	443456	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:443455_443456insA	ENST00000399788.2	-	11	1803_1804	c.1441_1442insT	c.(1441-1443)ctgfs	p.L481fs	KDM5A_ENST00000382815.4_Frame_Shift_Ins_p.L481fs	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	481	JmjC.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						AATGTGCCAGCAAAAAGAAGAG	0.431			T	NUP98	AML								49	81	---	---	---	---					
ALG10B	144245	broad.mit.edu	37	12	38714770	38714771	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:38714770_38714771insT	ENST00000308742.4	+	3	1493_1494	c.1177_1178insT	c.(1177-1179)tttfs	p.F393fs	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	393					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				ATCAAAGCCAATTTTTTGGAAT	0.307													44	78	---	---	---	---					
PUS7L	83448	broad.mit.edu	37	12	44148474	44148474	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:44148474delT	ENST00000416848.2	-	2	1063	c.575delA	c.(574-576)acfs	p.N192fs	PUS7L_ENST00000551923.1_Frame_Shift_Del_p.N192fs|PUS7L_ENST00000431332.3_Intron|PUS7L_ENST00000553166.1_Frame_Shift_Del_p.N192fs|PUS7L_ENST00000344862.5_Frame_Shift_Del_p.N192fs	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	192					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		AATTTCACTGTTTTTTCCTAC	0.333													25	62	---	---	---	---					
SCAF11	9169	broad.mit.edu	37	12	46320481	46320482	+	Frame_Shift_Ins	INS	-	-	T	rs139373352		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:46320481_46320482insT	ENST00000465950.1	-	1	3266_3267	c.2057_2058insA	c.(2056-2058)agafs	p.R686fs	SCAF11_ENST00000549162.1_Frame_Shift_Ins_p.R809fs|SCAF11_ENST00000369367.3_Frame_Shift_Ins_p.R1001fs|SCAF11_ENST00000419565.2_Frame_Shift_Ins_p.R1001fs			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1001					spliceosome assembly	nucleus	protein binding|zinc ion binding	p.N1001fs*2(1)		breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						GATGGATGTCATTTTTTTCTTT	0.386													53	103	---	---	---	---					
RP11-796E2.4	0	broad.mit.edu	37	12	92562666	92562666	+	RNA	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:92562666delA	ENST00000499685.2	+	0	164																											GTAGGTGTTTAAAAAAAAAAA	0.403													2	4	---	---	---	---					
EEA1	8411	broad.mit.edu	37	12	93195471	93195471	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:93195471delT	ENST00000322349.8	-	20	2941	c.2677delA	c.(2677-2679)ctfs	p.T893fs		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	893					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						TCTTTGCAAGTTTTTTCCTTA	0.284													10	16	---	---	---	---					
GNPTAB	79158	broad.mit.edu	37	12	102153878	102153879	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr12:102153878_102153879insT	ENST00000299314.7	-	16	3440_3441	c.3178_3179insA	c.(3178-3180)gctfs	p.A1060fs		NM_024312.4	NP_077288.2	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	1060					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						AGCAGGAAGCATTTTTGAGCAA	0.366													21	96	---	---	---	---					
ZMYM5	9205	broad.mit.edu	37	13	20426312	20426312	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:20426312delT	ENST00000337963.4	-	3	273	c.9delA	c.(7-9)aafs	p.K3fs	ZMYM5_ENST00000382907.4_Frame_Shift_Del_p.K3fs|ZMYM5_ENST00000382905.4_Frame_Shift_Del_p.K3fs	NM_001142684.1	NP_001136156.1	Q9UJ78	ZMYM5_HUMAN	zinc finger, MYM-type 5	3						nucleus	zinc ion binding			kidney(1)|large_intestine(5)|lung(9)	15		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		CCACTGAACATTTTTCCATGC	0.368													8	261	---	---	---	---					
SLC46A3	283537	broad.mit.edu	37	13	29287060	29287061	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:29287060_29287061insA	ENST00000266943.6	-	3	1185_1186	c.816_817insT	c.(814-819)tttggtfs	p.G273fs	SLC46A3_ENST00000380814.4_Frame_Shift_Ins_p.G273fs	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	273					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		CCAATTACCACAAAAAAATAAG	0.342													16	23	---	---	---	---					
USPL1	10208	broad.mit.edu	37	13	31205109	31205110	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:31205109_31205110insA	ENST00000255304.4	+	4	708_709	c.366_367insA	c.(364-369)tcaaaafs	p.SK122fs	USPL1_ENST00000465952.1_3'UTR	NM_005800.4	NP_005791.3	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	122					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(15)|pancreas(3)|skin(3)	34		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		TAGCAAATTCCAAAAAGACTAG	0.356													18	36	---	---	---	---					
PDS5B	23047	broad.mit.edu	37	13	33344887	33344888	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:33344887_33344888insA	ENST00000315596.10	+	33	4346_4347	c.4160_4161insA	c.(4159-4161)caafs	p.Q1387fs		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	1387					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding	p.N1390fs*4(1)		NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		CCATCACAACCAAAAAAAAATG	0.337													4	7	---	---	---	---					
PTMAP5	0	broad.mit.edu	37	13	82265133	82265134	+	RNA	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:82265133_82265134insT	ENST00000607242.1	+	0	1088_1089																											GTTGCTGTTTATTTTTTTTGGC	0.287													5	5	---	---	---	---					
UPF3A	65110	broad.mit.edu	37	13	115057211	115057211	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr13:115057211delA	ENST00000375299.3	+	7	846	c.790delA	c.(790-792)aafs	p.K266fs	UPF3A_ENST00000475218.2_3'UTR|UPF3A_ENST00000351487.5_Frame_Shift_Del_p.K233fs	NM_023011.3	NP_075387.1	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A (yeast)	266					mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		agaaagatgcaaaaaaaaaga	0.363													22	35	---	---	---	---					
TRAV34	0	broad.mit.edu	37	14	22675596	22675596	+	RNA	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:22675596delA	ENST00000390461.2	+	0	64																											ATGTGTTGGGAAAAAAAATGA	0.463													3	6	---	---	---	---					
AKAP6	9472	broad.mit.edu	37	14	32902725	32902725	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:32902725delC	ENST00000280979.4	+	2	196	c.26delC	c.(25-27)tcfs	p.S9fs	AKAP6_ENST00000557272.1_Frame_Shift_Del_p.S9fs|AKAP6_ENST00000557354.1_Frame_Shift_Del_p.S9fs|AKAP6_ENST00000554449.1_3'UTR	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	9					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GTGACACTTTCCCCCCTGAGG	0.507													23	29	---	---	---	---					
MIS18BP1	55320	broad.mit.edu	37	14	45675289	45675289	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:45675289delT	ENST00000310806.4	-	15	3695	c.3237delA	c.(3235-3237)aafs	p.K1079fs		NM_018353.4	NP_060823.3	Q6P0N0	M18BP_HUMAN	MIS18 binding protein 1	1079					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	39						TACTTACTAATTTTTTCTTGA	0.308													13	24	---	---	---	---					
ARID4A	5926	broad.mit.edu	37	14	58831137	58831137	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:58831137delA	ENST00000355431.3	+	20	2703	c.2330delA	c.(2329-2331)gafs	p.E777fs	ARID4A_ENST00000348476.3_Frame_Shift_Del_p.E777fs|ARID4A_ENST00000431317.2_Frame_Shift_Del_p.E777fs|ARID4A_ENST00000395168.3_Frame_Shift_Del_p.E777fs	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	777					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						AACAAAATGGAAAAAACAGAA	0.323													25	63	---	---	---	---					
SYNE2	23224	broad.mit.edu	37	14	64496757	64496758	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:64496757_64496758insA	ENST00000358025.3	+	44	7089_7090	c.6859_6860insA	c.(6859-6861)aaafs	p.K2287fs	SYNE2_ENST00000554584.1_Frame_Shift_Ins_p.K2287fs|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Frame_Shift_Ins_p.K2287fs	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2287					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGCGGTTGAGGAAAAATTGCAG	0.371													8	48	---	---	---	---					
AKAP5	9495	broad.mit.edu	37	14	64936178	64936178	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:64936178delA	ENST00000320636.5	+	1	2354	c.1066delA	c.(1066-1068)aafs	p.K356fs	AKAP5_ENST00000394718.3_Frame_Shift_Del_p.K356fs|ZBTB25_ENST00000555424.1_Intron|ZBTB25_ENST00000555220.1_Intron			P24588	AKAP5_HUMAN	A kinase (PRKA) anchor protein 5	356					energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|stomach(1)	13				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		TACAAAATCTAAAAATGTCCC	0.323													53	80	---	---	---	---					
RP11-643G16.4	0	broad.mit.edu	37	14	68082888	68082888	+	RNA	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr14:68082888delA	ENST00000559968.1	+	0	1243																											TTTTAAAGACAAAAAAAATTT	0.328													14	63	---	---	---	---					
SNHG14	0	broad.mit.edu	37	15	25351683	25351684	+	RNA	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:25351683_25351684insA	ENST00000546682.1	+	0	3911				SNHG14_ENST00000553108.1_RNA|SNHG14_ENST00000549804.2_RNA|SNORD116-29_ENST00000384516.1_RNA	NR_003361.1																						GATGATGACTTAAAAAAATGGA	0.470													14	42	---	---	---	---					
HERC1	8925	broad.mit.edu	37	15	63970404	63970405	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:63970404_63970405insT	ENST00000443617.2	-	37	6796_6797	c.6709_6710insA	c.(6709-6711)gatfs	p.D2237fs	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2237					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CCTTTCCATCATTTTTTTGTTA	0.426													10	17	---	---	---	---					
FAM154B	283726	broad.mit.edu	37	15	82575034	82575034	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr15:82575034delT	ENST00000339465.5	+	3	897	c.828delT	c.(826-828)aafs	p.N276fs	FAM154B_ENST00000565501.1_3'UTR|FAM154B_ENST00000427381.2_Frame_Shift_Del_p.N261fs	NM_001008226.1	NP_001008227.1	Q658L1	F154B_HUMAN	family with sequence similarity 154, member B	276										autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)	19						GAAGTAACAATTTTCCTTTCC	0.413													25	58	---	---	---	---					
RRN3P2	0	broad.mit.edu	37	16	29113498	29113498	+	RNA	DEL	T	T	-	rs11366120		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:29113498delT	ENST00000564580.1	+	0	1360																											AGGAGGTGGAttttttttttc	0.542													3	4	---	---	---	---					
MARVELD3	91862	broad.mit.edu	37	16	71668441	71668442	+	Frame_Shift_Ins	INS	-	-	G	rs150498655	byFrequency	TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr16:71668441_71668442insG	ENST00000268485.3	+	3	985_986	c.941_942insG	c.(940-942)gggfs	p.G314fs	MARVELD3_ENST00000565261.1_Intron|MARVELD3_ENST00000567501.1_3'UTR|MARVELD3_ENST00000299952.4_Intron	NM_052858.3	NP_443090.4	Q96A59	MALD3_HUMAN	MARVEL domain containing 3	314	MARVEL.					integral to membrane		p.A314V(1)		NS(1)|endometrium(3)|large_intestine(5)|lung(6)|skin(2)	17		Ovarian(137;0.125)				ATGCTCATCGCGGGGGGGTACA	0.579													7	30	---	---	---	---					
ABR	29	broad.mit.edu	37	17	1028642	1028642	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:1028642delG	ENST00000302538.5	-	2	268	c.122delC	c.(121-123)cgfs	p.P41fs	ABR_ENST00000544583.2_5'UTR|ABR_ENST00000574437.1_5'UTR	NM_021962.3	NP_068781.2	Q12979	ABR_HUMAN	active BCR-related	41					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity	p.P41fs*51(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		TGAGCCCTCCGGGGGCCCCTT	0.642													32	71	---	---	---	---					
FAM27L	284123	broad.mit.edu	37	17	21825597	21825597	+	RNA	DEL	C	C	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:21825597delC	ENST00000426869.3	+	0	278					NR_028336.1				family with sequence similarity 27-like											central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		aaaagtcgtgcccccgtgatc	0.627													7	27	---	---	---	---					
FBXL20	84961	broad.mit.edu	37	17	37431355	37431356	+	Splice_Site	INS	-	-	A	rs34511351		TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:37431355_37431356insA	ENST00000264658.6	-	10	957		c.e10-2		FBXL20_ENST00000577399.1_Splice_Site|FBXL20_ENST00000394294.3_Splice_Site|FBXL20_ENST00000583610.1_Splice_Site	NM_032875.2	NP_116264.2	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20							cytoplasm				breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22			LUAD - Lung adenocarcinoma(14;0.146)			TGTGATTTGCTAAAAAACAAGA	0.356													16	25	---	---	---	---					
TTLL6	284076	broad.mit.edu	37	17	46862492	46862493	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:46862492_46862493insT	ENST00000393382.3	-	13	1973_1974	c.1832_1833insA	c.(1831-1833)agafs	p.R611fs	TTLL6_ENST00000433608.2_Frame_Shift_Ins_p.R304fs	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	563						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						TGTCTGTTTCATTTTTCCTTTC	0.520													30	36	---	---	---	---					
DDX42	11325	broad.mit.edu	37	17	61892959	61892959	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:61892959delA	ENST00000578681.1	+	17	2540	c.1939delA	c.(1939-1941)aafs	p.K647fs	DDX42_ENST00000583590.1_Frame_Shift_Del_p.K647fs|DDX42_ENST00000457800.2_Frame_Shift_Del_p.K647fs|DDX42_ENST00000389924.2_Frame_Shift_Del_p.K647fs|DDX42_ENST00000359353.5_Frame_Shift_Del_p.K528fs	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	647					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						CAAAGGAGGGAAAGGAAAAAA	0.483													7	56	---	---	---	---					
KIAA0195	9772	broad.mit.edu	37	17	73493881	73493881	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr17:73493881delC	ENST00000314256.7	+	27	3821	c.3427delC	c.(3427-3429)ccfs	p.P1144fs	KIAA0195_ENST00000375248.5_Frame_Shift_Del_p.P1154fs|KIAA0195_ENST00000579208.1_Frame_Shift_Del_p.P795fs	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	1144					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTGGGGAAGCCCCCCCATAG	0.517													19	90	---	---	---	---					
TRAPPC8	22878	broad.mit.edu	37	18	29488331	29488331	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:29488331delT	ENST00000283351.4	-	8	1508	c.1173delA	c.(1171-1173)aafs	p.K391fs	TRAPPC8_ENST00000582513.1_Frame_Shift_Del_p.K391fs|TRAPPC8_ENST00000582539.1_Frame_Shift_Del_p.K337fs	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	391					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CACTAAACCATTTTTTAGTTG	0.299													16	37	---	---	---	---					
HAUS1	115106	broad.mit.edu	37	18	43685173	43685174	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:43685173_43685174insA	ENST00000282058.6	+	2	124_125	c.44_45insA	c.(43-45)taafs	p.*15fs	HAUS1_ENST00000585518.1_Frame_Shift_Ins_p.*15fs	NM_138443.3	NP_612452.1	Q96CS2	HAUS1_HUMAN	HAUS augmin-like complex, subunit 1	15					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	7						GCTGCGTGGTTAAAAAAAATAT	0.391													21	36	---	---	---	---					
DYM	54808	broad.mit.edu	37	18	46784852	46784853	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr18:46784852_46784853insT	ENST00000269445.6	-	12	1719_1720	c.1262_1263insA	c.(1261-1263)aatfs	p.N421fs	DYM_ENST00000442713.2_Frame_Shift_Ins_p.N231fs	NM_017653.3	NP_060123.3	Q7RTS9	DYM_HUMAN	dymeclin	421						Golgi apparatus				NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	18						ACCAAGTAATATTTTTTAGTAT	0.342													10	31	---	---	---	---					
SF3A2	8175	broad.mit.edu	37	19	2248531	2248531	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:2248531delC	ENST00000221494.4	+	9	1799	c.1381delC	c.(1381-1383)ccfs	p.P462fs		NM_007165.4	NP_009096.2	Q15428	SF3A2_HUMAN	splicing factor 3a, subunit 2, 66kDa	462	Pro-rich.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex	nucleic acid binding|zinc ion binding			NS(1)|large_intestine(1)|lung(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTCCCCCTCCCCCAACCAA	0.627													2	4	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9059156	9059157	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:9059156_9059157insT	ENST00000397910.4	-	3	28492_28493	c.28289_28290insA	c.(28288-28290)aagfs	p.K9430fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9432	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGGAGGGCTGTTTTTTTCCAC	0.510													57	68	---	---	---	---					
COL5A3	50509	broad.mit.edu	37	19	10091514	10091515	+	Frame_Shift_Ins	INS	-	-	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:10091514_10091515insC	ENST00000264828.3	-	34	2611_2612	c.2526_2527insG	c.(2524-2529)ggaaccfs	p.T843fs		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	843	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GCACCCGGTTGCCCCCTCTCTC	0.599													9	17	---	---	---	---					
ZNF44	51710	broad.mit.edu	37	19	12384448	12384448	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:12384448delA	ENST00000356109.5	-	5	884	c.766delT	c.(766-768)ggfs	p.W256fs	ZNF44_ENST00000355684.5_Frame_Shift_Del_p.W208fs	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		AAACTGGGCCAAAAAAAGGCT	0.398													42	52	---	---	---	---					
ZNF431	170959	broad.mit.edu	37	19	21365724	21365725	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:21365724_21365725insA	ENST00000311048.7	+	5	762_763	c.618_619insA	c.(616-621)tgaaaafs	p.*K206fs	ZNF431_ENST00000594425.1_Intron|ZNF431_ENST00000600692.1_3'UTR	NM_133473.2	NP_597730.2	Q8TF32	ZN431_HUMAN	zinc finger protein 431	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23						CTTTCAAATGTAAAAAATGTGG	0.292													21	49	---	---	---	---					
WBP7	0	broad.mit.edu	37	19	36223002	36223002	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr19:36223002delG	ENST00000222270.7	+	27	5631	c.5631delG	c.(5629-5631)ttfs	p.L1877fs	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Frame_Shift_Del_p.L1877fs	NM_014727.1	NP_055542.1												p.G1881fs*16(1)									GGAGGCCCTTGGGGGGTGTCT	0.672													9	11	---	---	---	---					
E2F1	1869	broad.mit.edu	37	20	32264549	32264549	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:32264549delG	ENST00000343380.5	-	7	1442	c.1303delC	c.(1303-1305)tgfs	p.L435fs		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	435	Transactivation.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						CAGAAATCCAGGGGGGTGAGG	0.642													5	4	---	---	---	---					
ZNFX1	57169	broad.mit.edu	37	20	47872451	47872451	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:47872451delT	ENST00000396105.1	-	9	2944	c.2698delA	c.(2698-2700)gafs	p.R900fs	ZNFX1_ENST00000371752.1_Frame_Shift_Del_p.R900fs|ZNFX1_ENST00000371754.4_Frame_Shift_Del_p.R900fs	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	900							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCCTTCACTCTTTTTTTCATT	0.517													15	31	---	---	---	---					
C20orf85	128602	broad.mit.edu	37	20	56735727	56735727	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr20:56735727delC	ENST00000371168.3	+	4	324	c.263delC	c.(262-264)tcfs	p.S88fs		NM_178456.2	NP_848551.1	Q9H1P6	CT085_HUMAN	chromosome 20 open reading frame 85	88										kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	13	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			GTCTTTCCATCCCCCCCAGTC	0.582													10	9	---	---	---	---					
BRWD1	54014	broad.mit.edu	37	21	40582837	40582837	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr21:40582837delT	ENST00000342449.3	-	35	3997	c.3919delA	c.(3919-3921)gcfs	p.S1307fs	BRWD1_ENST00000380800.3_Frame_Shift_Del_p.S1307fs|BRWD1_ENST00000333229.2_Frame_Shift_Del_p.S1307fs	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GCTCTGATGCTTTTTTTCCCA	0.348													11	21	---	---	---	---					
IGLJ5	0	broad.mit.edu	37	22	23256417	23256417	+	RNA	DEL	T	T	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:23256417delT	ENST00000390327.2	+	0	10																											CCAGAGAGGGTTTTTGTATGA	0.597													18	38	---	---	---	---					
LIMK2	3985	broad.mit.edu	37	22	31672776	31672777	+	Splice_Site	INS	-	-	C			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:31672776_31672777insC	ENST00000340552.4	+	15	1941_1942	c.1709_splice	c.e15-1	p.P571_splice	LIMK2_ENST00000406516.1_Splice_Site_p.P514_splice|LIMK2_ENST00000333611.4_Intron|LIMK2_ENST00000444929.2_Intron|LIMK2_ENST00000467301.1_Intron|LIMK2_ENST00000331728.4_Intron	NM_001031801.1	NP_001026971.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	0	Protein kinase.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						TACTTTCAGAGCCCCCCCCGGG	0.733													13	5	---	---	---	---					
EFCAB6	64800	broad.mit.edu	37	22	43930616	43930617	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chr22:43930616_43930617insT	ENST00000262726.7	-	30	4437_4438	c.4184_4185insA	c.(4183-4185)agafs	p.R1395fs	EFCAB6-AS1_ENST00000431327.2_RNA|EFCAB6_ENST00000461800.1_5'UTR|EFCAB6_ENST00000396231.2_Frame_Shift_Ins_p.R1243fs	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1395	Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GTGAGCTTTCCTTTGCTTTTAG	0.475													32	52	---	---	---	---					
RBM10	8241	broad.mit.edu	37	X	47030586	47030588	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:47030586_47030588delGAG	ENST00000377604.3	+	4	1103_1105	c.361_363delGAG	c.(361-363)del	p.E125del	RBM10_ENST00000329236.7_Intron|RBM10_ENST00000468791.1_3'UTR|RBM10_ENST00000345781.6_Intron	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	125	Poly-Glu.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						ggaggaggatgaggaggaggagg	0.665													2	4	---	---	---	---					
POU3F4	5456	broad.mit.edu	37	X	82764058	82764059	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIW-01A-11D-A41K-08	TCGA-XK-AAIW-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f8f11c1-ad41-4a60-9cd0-6df43a1c0ceb	8691e950-9a7a-48e2-aa6b-63e4efc353a5	g.chrX:82764058_82764059insA	ENST00000373200.2	+	1	790_791	c.726_727insA	c.(724-729)ttaaaafs	p.LK242fs	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	242	POU-specific.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						AGCTGAGCTTCAAAAATATGTG	0.584													13	6	---	---	---	---					
