Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CTD-2620I22.1	0	broad.mit.edu	37	19	53472914	53472914	+	RNA	SNP	A	A	G			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr19:53472914A>G	ENST00000600068.1	-	0	489				ZNF702P_ENST00000270443.4_RNA																							TTTGATTTTCAATTAAAAACC	0.338000													4	20					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102293008	102293008	+	RNA	SNP	A	A	G			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr15:102293008A>G	ENST00000561463.1	+	0	1054																		p.K171E(1)									GCGTGGGAACAAGAAGACACT	0.582000													3	11					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73717486	73717486	+	Silent	SNP	T	T	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr2:73717486T>A	ENST00000264448.6	+	10	8508	c.8397T>A	c.(8395-8397)gtT>gtA	p.V2799V	ALMS1_ENST00000409009.1_Silent_p.V2757V	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2799					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						AATTACCTGTTGATTTTGAGC	0.363000													9	36					0	0	1	0	0
FBXL17	64839	broad.mit.edu	37	5	107700657	107700657	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr5:107700657G>T	ENST00000542267.1	-	3	1562	c.1156C>A	c.(1156-1158)Cag>Aag	p.Q386K	FBXL17_ENST00000496714.1_5'UTR|FBXL17_ENST00000359660.5_5'UTR	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	386										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		ATTATATTCTGACTTCTTGAT	0.303000													16	51					4.7546e-09	5.00485e-09	1	1	0
SERINC3	10955	broad.mit.edu	37	20	43141574	43141574	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr20:43141574T>A	ENST00000342374.4	-	3	420	c.263A>T	c.(262-264)gAt>gTt	p.D88V	SERINC3_ENST00000255175.1_Missense_Mutation_p.D88V|SERINC3_ENST00000541235.1_Missense_Mutation_p.D33V	NM_006811.2	NP_006802.1	Q13530	SERC3_HUMAN	serine incorporator 3	88						integral to membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(2)|lung(8)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			CACATCACAATCTTTATCTGC	0.363000													4	53					0	0	1	0	0
ASB4	51666	broad.mit.edu	37	7	95167003	95167003	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr7:95167003C>T	ENST00000325885.5	+	5	1284	c.1213C>T	c.(1213-1215)Cct>Tct	p.P405S		NM_016116.2	NP_057200.1	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box containing 4	405	SOCS box.				intracellular signal transduction			p.P405S(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|pancreas(1)|prostate(1)|skin(2)	20	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			TAGAGCAATTCCTTTGCTTTC	0.413000													10	73					0	0	1	0	0
PCDHGA3	0	broad.mit.edu	37	5	140723674	140723674	+	Missense_Mutation	SNP	A	A	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr5:140723674A>T	ENST00000253812.6	+	1	74	c.74A>T	c.(73-75)gAa>gTa	p.E25V	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCTGTGCGAAACAGGATCC	0.572000											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	121					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39262596	39262596	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr2:39262596G>A	ENST00000426016.1	-	8	996	c.910C>T	c.(910-912)Cga>Tga	p.R304*	SOS1_ENST00000428721.2_Nonsense_Mutation_p.R247*|SOS1_ENST00000402219.2_Nonsense_Mutation_p.R304*|SOS1_ENST00000395038.2_Nonsense_Mutation_p.R304*			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	304	DH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				AAACCAGGTCGCAAAATATCT	0.338000									Noonan syndrome				4	59					0	0	1	0	0
ANKRD28	23243	broad.mit.edu	37	3	15749534	15749534	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr3:15749534G>C	ENST00000399451.2	-	14	1721	c.1354C>G	c.(1354-1356)Cag>Gag	p.Q452E	ANKRD28_ENST00000383777.1_Missense_Mutation_p.Q485E|ANKRD28_ENST00000497037.1_5'UTR	NM_001195098.1|NM_001195099.1|NM_015199.3	NP_001182027.1|NP_001182028.1|NP_056014.2	O15084	ANR28_HUMAN	ankyrin repeat domain 28	452						nucleoplasm	protein binding			breast(2)|endometrium(1)|large_intestine(2)|prostate(1)	6						AACAGGCACTGGTAATTGCAG	0.458000													4	8					0	0	1	0	0
SASH1	23328	broad.mit.edu	37	6	148865285	148865285	+	Silent	SNP	A	A	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr6:148865285A>T	ENST00000367467.3	+	18	3154	c.2679A>T	c.(2677-2679)ctA>ctT	p.L893L		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	893							protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		ATGCATTGCTACTGACCCAAA	0.552000													32	119					0	0	1	0	0
LCE1D	353134	broad.mit.edu	37	1	152770577	152770577	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr1:152770577G>A	ENST00000326233.6	+	2	350	c.307G>A	c.(307-309)Ggt>Agt	p.G103S		NM_178352.2	NP_848129.1	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	103	Cys-rich.				cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm				large_intestine(1)	1	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGCTGCTGCGGTGGGGGCAG	0.632000													7	12					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111862949	111862949	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr1:111862949C>T	ENST00000369740.1	+	12	1395	c.1292C>T	c.(1291-1293)gCt>gTt	p.A431V	CHIA_ENST00000353665.6_Missense_Mutation_p.A270V|CHIA_ENST00000343320.6_Missense_Mutation_p.A431V|CHIA_ENST00000483391.1_Missense_Mutation_p.A270V|CHIA_ENST00000451398.2_Missense_Mutation_p.A270V|CHIA_ENST00000430615.1_Missense_Mutation_p.A323V|RP5-1125M8.2_ENST00000426321.1_RNA	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	431	Chitin-binding type-2.				apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		GGATTCTGTGCTGTCAGAGCC	0.602000													7	29					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150738258	150738258	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr7:150738258G>A	ENST00000358849.4	+	13	1649	c.1556G>A	c.(1555-1557)cGg>cAg	p.R519Q	ABCB8_ENST00000297504.6_Missense_Mutation_p.R536Q|ABCB8_ENST00000542328.1_Missense_Mutation_p.R431Q|ABCB8_ENST00000498578.1_Missense_Mutation_p.R519Q|ABCB8_ENST00000356058.4_3'UTR	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	536	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGGATGGGCGGGACCTGCGC	0.677000													3	38					0	0	1	0	0
NDUFA12	55967	broad.mit.edu	37	12	95396517	95396517	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr12:95396517A>G	ENST00000327772.2	-	2	256	c.167T>C	c.(166-168)tTt>tCt	p.F56S	NDUFA12_ENST00000547157.1_Intron|NDUFA12_ENST00000547986.1_Missense_Mutation_p.F56S	NM_018838.4	NP_061326.1	Q9UI09	NDUAC_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12	56					respiratory electron transport chain|respiratory gaseous exchange|response to oxidative stress|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			endometrium(1)|large_intestine(2)|lung(3)	6					NADH(DB00157)	GCACTCACCAAAAAATTGCTT	0.338000													11	36					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16675127	16675127	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr5:16675127C>T	ENST00000513610.1	-	35	5253	c.4799G>A	c.(4798-4800)cGa>cAa	p.R1600Q	MYO10_ENST00000427430.2_Missense_Mutation_p.R957Q|MYO10_ENST00000505695.1_Missense_Mutation_p.R939Q|MYO10_ENST00000515803.1_Missense_Mutation_p.R939Q|MYO10_ENST00000274203.9_Missense_Mutation_p.R957Q	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1600	MyTH4.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						CCGCAGAGGTCGCAGGTCATG	0.542000													3	36					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11144059	11144059	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr19:11144059A>C	ENST00000358026.2	+	26	3924	c.3640A>C	c.(3640-3642)Atc>Ctc	p.I1214L	SMARCA4_ENST00000444061.3_Missense_Mutation_p.I1214L|SMARCA4_ENST00000590574.1_Missense_Mutation_p.I1214L|SMARCA4_ENST00000413806.3_Missense_Mutation_p.I1214L|SMARCA4_ENST00000429416.3_Missense_Mutation_p.I1214L|SMARCA4_ENST00000541122.2_Missense_Mutation_p.I1214L|SMARCA4_ENST00000344626.4_Missense_Mutation_p.I1214L|SMARCA4_ENST00000589677.1_Missense_Mutation_p.I1214L|SMARCA4_ENST00000450717.3_Missense_Mutation_p.I1214L	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1214	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GGAGGAGAAGATCCTAGCTGC	0.637000			"""F, N, Mis"""		NSCLC								18	53					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75668148	75668148	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr16:75668148C>T	ENST00000319410.5	-	8	1043	c.922G>A	c.(922-924)Gcc>Acc	p.A308T	KARS_ENST00000568378.1_Intron|KARS_ENST00000302445.3_Missense_Mutation_p.A280T	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	280					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	AAAGGCTTGGCCACGGCTCCC	0.448000													14	49					0	0	1	0	0
TRBV20-1	0	broad.mit.edu	37	7	142334684	142334684	+	RNA	SNP	G	G	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr7:142334684G>A	ENST00000390394.3	+	0	184																											TGTGAAGATCGAGTGCCGTTC	0.522000											OREG0018395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	64					0	0	1	0	0
RP11-798G7.6	0	broad.mit.edu	37	17	43625275	43625275	+	RNA	SNP	A	A	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr17:43625275A>T	ENST00000586348.1	+	0	45																											TTTGGGTGTAACTTTCAGACT	0.493000													15	64					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128990698	128990698	+	Silent	SNP	G	G	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr3:128990698G>A	ENST00000314797.6	+	19	2036	c.1932G>A	c.(1930-1932)acG>acA	p.T644T		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	644	Interaction with ZNF289/ARFGAP2.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										AGTCAGAGACGGAGTATGTCA	0.607000													5	22					0	0	1	0	0
CPEB4	80315	broad.mit.edu	37	5	173317158	173317158	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr5:173317158C>A	ENST00000265085.5	+	1	1876	c.422C>A	c.(421-423)aCa>aAa	p.T141K	CPEB4_ENST00000334035.5_Missense_Mutation_p.T141K|CPEB4_ENST00000519835.1_Missense_Mutation_p.T141K|CPEB4_ENST00000520867.1_Missense_Mutation_p.T141K	NM_030627.2	NP_085130.2	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding protein 4	141							nucleotide binding|RNA binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	20	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCAGTGTTGACAGGGTTTGAT	0.453000													6	77					4.096e-09	4.42811e-09	1	1	0
HSF5	124535	broad.mit.edu	37	17	56557586	56557586	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr17:56557586T>G	ENST00000323777.3	-	2	702	c.593A>C	c.(592-594)gAt>gCt	p.D198A		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	198						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGACAAACTATCTCGACGAAA	0.433000													10	20					0	0	1	0	0
FAM86FP	0	broad.mit.edu	37	12	8386973	8386973	+	RNA	SNP	C	C	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr12:8386973C>T	ENST00000427893.2	-	0	793																											AGCCAGCCTCCGCAGGACCCC	0.592000													3	37					0	0	1	0	0
ZNF34	80778	broad.mit.edu	37	8	145998934	145998934	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr8:145998934C>A	ENST00000429371.2	-	6	1490	c.1337G>T	c.(1336-1338)aGa>aTa	p.R446I	ZNF34_ENST00000343459.4_Missense_Mutation_p.R467I	NM_030580.3	NP_085057.3	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		TGTGTGGATTCTCTGGTGCTG	0.537000													4	44					1	1	1	1	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	41					0	0	1	0	0
ZNF878	729747	broad.mit.edu	37	19	12155673	12155673	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr19:12155673A>C	ENST00000602107.1	-	5	683	c.684T>G	c.(682-684)agT>agG	p.S228R	CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591898.1_RNA|CTD-2006C1.2_ENST00000476474.1_RNA|ZNF878_ENST00000547628.1_Missense_Mutation_p.S181R|CTD-2006C1.2_ENST00000591838.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						AACTGGGAAAACTGAATGCTT	0.403000													5	202					0	0	1	0	0
PGS1	9489	broad.mit.edu	37	17	76395604	76395604	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr17:76395604C>A	ENST00000262764.6	+	5	713	c.687C>A	c.(685-687)agC>agA	p.S229R	PGS1_ENST00000588281.1_3'UTR|PGS1_ENST00000329897.7_Missense_Mutation_p.S94R	NM_024419.3	NP_077733.3	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	229	PLD phosphodiesterase 1.				phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity			cervix(2)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	10			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			TCGACAACAGCGTCATCTTGA	0.597000													4	45					0.000602214	0.000617656	1	1	0
PCDHGA3	0	broad.mit.edu	37	5	140723673	140723673	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr5:140723673G>C	ENST00000253812.6	+	1	73	c.73G>C	c.(73-75)Gaa>Caa	p.E25Q	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGCTGTGCGAAACAGGATC	0.567000											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	120					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92085830	92085830	+	Silent	SNP	C	C	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr11:92085830C>T	ENST00000298047.6	+	1	569	c.552C>T	c.(550-552)gaC>gaT	p.D184D	FAT3_ENST00000525166.1_Silent_p.D34D|FAT3_ENST00000409404.2_Silent_p.D184D|FAT3_ENST00000541502.1_Silent_p.D184D			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	184	Cadherin 2.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.D184D(2)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTGCAACAGACGCAGATATTG	0.423000										TCGA Ovarian(4;0.039)			6	35					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87160785	87160785	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr7:87160785G>A	ENST00000265724.3	-	22	2927	c.2510C>T	c.(2509-2511)aCc>aTc	p.T837I	ABCB1_ENST00000543898.1_Missense_Mutation_p.T773I|ABCB1_ENST00000488737.2_5'UTR	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	837	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TATATTCTGGGTAATTACAGC	0.328000													9	33					0	0	1	0	0
IFRD2	7866	broad.mit.edu	37	3	50330064	50330064	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr3:50330064G>A	ENST00000336089.4	-	2	240	c.241C>T	c.(241-243)Cgc>Tgc	p.R81C	IFRD2_ENST00000436390.1_5'UTR			Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	86							binding			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AATGCCCTGCGCGCGCCCCAG	0.662000													12	48					0	0	1	0	0
DPPA5	340168	broad.mit.edu	37	6	74063897	74063897	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr6:74063897C>T	ENST00000370370.3	-	1	121	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K		NM_001025290.2	NP_001020461.1	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	18					multicellular organismal development	cytoplasm	RNA binding			NS(1)|endometrium(1)|lung(5)	7						TTCAGGTCTTCGGGAACTTTC	0.587000													14	50					0	0	1	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													4	15					0	0	1	0	0
EMC3	55831	broad.mit.edu	37	3	10011467	10011468	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr3:10011467_10011468insT	ENST00000245046.2	-	7	1050_1051	c.592_593insA	c.(592-594)gatfs	p.D198fs	EMC3_ENST00000497557.1_5'UTR	NM_018447.2	NP_060917.1			ER membrane protein complex subunit 3																		CTCCTGCATCATTCGTGATTGG	0.525													20	71	---	---	---	---					
EEF1A1	1915	broad.mit.edu	37	6	74228229	74228244	+	Frame_Shift_Del	DEL	CGACAGATTTTACTTC	CGACAGATTTTACTTC	-			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr6:74228229_74228244delCGACAGATTTTACTTC	ENST00000316292.9	-	5	1853_1868	c.862_877delGAAGTAAAATCTGTCG	c.(862-879)aafs	p.EVKSVE288fs	EEF1A1_ENST00000331523.2_Frame_Shift_Del_p.EVKSVE288fs|EEF1A1_ENST00000491404.1_Intron|EEF1A1_ENST00000309268.6_Frame_Shift_Del_p.EVKSVE288fs	NM_001402.5	NP_001393.1	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha 1	288						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity	p.V292V(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|prostate(2)|skin(3)	18						TGGTGCATTTCGACAGATTTTACTTCCGTTGTAACG	0.468											OREG0003895	type=REGULATORY REGION|Gene=D16891|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	33	---	---	---	---					
PTEN	5728	broad.mit.edu	37	10	89653814	89653814	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr10:89653814delC	ENST00000371953.3	+	2	1469	c.112delC	c.(112-114)ctfs	p.P38fs		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	38	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(8)|p.P38S(5)|p.Y27fs*1(2)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TATGGGATTTCCTGCAGAAAG	0.284		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			15	33	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													4	8	---	---	---	---					
ZNF878	729747	broad.mit.edu	37	19	12157184	12157184	+	Splice_Site	DEL	T	T	-			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr19:12157184delT	ENST00000602107.1	-	4	330	c.332_splice	c.e4+1	p.R112_splice	ZNF878_ENST00000547628.1_Splice_Site_p.R65_splice|CTD-2006C1.10_ENST00000547473.1_Splice_Site_p.R64_splice			C9JN71	ZN878_HUMAN	zinc finger protein 878	65					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						GCCAGTTACCTTAGGTTTCTC	0.348													2	4	---	---	---	---					
IRGQ	126298	broad.mit.edu	37	19	44096566	44096568	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chr19:44096566_44096568delGCC	ENST00000422989.1	-	3	1637_1639	c.1482_1484delGGC	c.(1480-1485)gca>gc	p.AA494del	L34079.2_ENST00000594374.1_Intron|IRGQ_ENST00000602269.1_In_Frame_Del_p.AA494del|IRGQ_ENST00000601520.1_Intron	NM_001007561.2	NP_001007562.1	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	494	Ala-rich.						protein binding	p.A495delA(1)		endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(3)	18		Prostate(69;0.0199)				TGGGAGTGGTGCCGCCGCCGCCG	0.729													2	4	---	---	---	---					
OTC	5009	broad.mit.edu	37	X	38229085	38229086	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chrX:38229085_38229086insT	ENST00000039007.4	+	3	405_406	c.253_254insT	c.(253-255)tttfs	p.F85fs	OTC_ENST00000488812.1_3'UTR|TM4SF2_ENST00000465127.1_Intron	NM_000531.5	NP_000522.3	P00480	OTC_HUMAN	ornithine carbamoyltransferase	85					arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22					L-Citrulline(DB00155)|L-Ornithine(DB00129)	CTTAGGCATGATTTTTGAGAAA	0.322													20	34	---	---	---	---					
CYSLTR1	0	broad.mit.edu	37	X	77528275	77528276	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chrX:77528275_77528276insTT	ENST00000373304.3	-	3	1260_1261	c.968_969insAA	c.(967-969)aaafs	p.K323fs		NM_006639.2	NP_006630.1	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	323					elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	AAGAGGCCTTCTTTCTGGGTAC	0.366													12	23	---	---	---	---					
TXLNG2P	0	broad.mit.edu	37	Y	21758039	21758039	+	RNA	DEL	A	A	-			TCGA-ZG-A9L2-01A-31D-A41K-08	TCGA-ZG-A9L2-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c18a4706-70cf-463a-be68-fffa9c36c5d6	63ce1033-5b0b-48a7-9a5c-3e0ac6cad45d	g.chrY:21758039delA	ENST00000253320.4	+	0	3120							Q9BZA5	CY15A_HUMAN												haematopoietic_and_lymphoid_tissue(1)	1						TACTTCTTGGAAAAAAAAAAA	0.378													2	4	---	---	---	---					
