Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NDST3	9348	broad.mit.edu	37	4	118975475	118975475	+	Nonsense_Mutation	SNP	T	T	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr4:118975475T>A	ENST00000296499.5	+	2	813	c.410T>A	c.(409-411)tTa>tAa	p.L137*	NDST3_ENST00000433996.2_Nonsense_Mutation_p.L137*	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	137	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						GAGAATATTTTAAAGTATATA	0.353000													3	39					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11017093	11017093	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr16:11017093C>T	ENST00000324288.8	+	19	3459	c.3326C>T	c.(3325-3327)aCg>aTg	p.T1109M	CIITA_ENST00000381835.5_Missense_Mutation_p.T525M	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	1109					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						AGGATGTGGACGCCCACCATC	0.607000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								8	114					0	0	1	0	0
AC024560.3	0	broad.mit.edu	37	3	197348668	197348668	+	RNA	SNP	C	C	G	rs79940815	by1000genomes	TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr3:197348668C>G	ENST00000418868.1	-	0	591					NR_003266.2																						ACTTGAGGCTCTGTCCACCAA	0.488000													4	81					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74967622	74967622	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr14:74967622C>T	ENST00000261978.4	-	36	5817	c.5431G>A	c.(5431-5433)Gag>Aag	p.E1811K	LTBP2_ENST00000556690.1_Missense_Mutation_p.E1767K	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1811	EGF-like 20; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGCCCTGCCTCAGCCACATAT	0.612000													6	46					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16354924	16354924	+	Silent	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr20:16354924G>A	ENST00000354981.2	-	20	3485	c.3328C>T	c.(3328-3330)Ctg>Ttg	p.L1110L	KIF16B_ENST00000378003.2_Silent_p.L336L|KIF16B_ENST00000355755.3_Silent_p.L1110L|KIF16B_ENST00000408042.1_Silent_p.L1110L	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	1110					cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						AGGGGAACCAGGTGTGATTTT	0.458000													5	79					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													5	28					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241904837	241904837	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr1:241904837G>A	ENST00000366552.2	+	11	1518	c.1311G>A	c.(1309-1311)atG>atA	p.M437I	WDR64_ENST00000437684.2_Missense_Mutation_p.M437I	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	437										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			TTATGGACATGTATCCTTTGA	0.353000													6	44					0	0	1	0	0
HERC2P2	0	broad.mit.edu	37	15	23300079	23300079	+	RNA	SNP	T	T	G	rs417713	by1000genomes	TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr15:23300079T>G	ENST00000560464.1	-	0	4208																											GTGCTGCACGTTGACAGGCGT	0.607000													5	19					0	0	1	0	0
OR6Q1	219952	broad.mit.edu	37	11	57798830	57798830	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr11:57798830T>G	ENST00000302622.3	+	1	429	c.406T>G	c.(406-408)Tat>Gat	p.Y136D	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				GCCTCTCCACTATGGGGCTTT	0.527000													6	61					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50212006	50212006	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr19:50212006G>C	ENST00000392518.4	+	14	1848	c.1476G>C	c.(1474-1476)caG>caC	p.Q492H	CPT1C_ENST00000354199.5_Missense_Mutation_p.Q492H|CPT1C_ENST00000598293.1_Missense_Mutation_p.Q492H|CPT1C_ENST00000405931.2_Missense_Mutation_p.Q481H|CPT1C_ENST00000323446.5_Missense_Mutation_p.Q492H	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	492					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		AATGCTTTCAGCTGGGCTACT	0.602000													4	89					0	0	1	0	0
NUP43	348995	broad.mit.edu	37	6	150067084	150067084	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr6:150067084C>A	ENST00000340413.2	-	2	311	c.235G>T	c.(235-237)Gat>Tat	p.D79Y	NUP43_ENST00000367403.3_Missense_Mutation_p.D140Y|NUP43_ENST00000460354.2_Missense_Mutation_p.D79Y|NUP43_ENST00000463048.3_5'UTR|NUP43_ENST00000367404.4_Missense_Mutation_p.D79Y	NM_198887.1	NP_942590.1	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	79					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			breast(1)|large_intestine(2)|lung(8)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		ACCTGTAAATCCATTACATCA	0.393000													7	87					8.12818e-05	8.61588e-05	1	1	0
TAF1L	138474	broad.mit.edu	37	9	32631138	32631138	+	Silent	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr9:32631138C>T	ENST00000242310.4	-	1	4529	c.4440G>A	c.(4438-4440)ggG>ggA	p.G1480G		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1480	Bromo 1.				male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AATGTTTTGGCCCATTGTAGG	0.418000													4	174					0	0	1	0	0
HERC2P2	0	broad.mit.edu	37	15	23300033	23300033	+	RNA	SNP	T	T	C	rs1058831	by1000genomes	TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr15:23300033T>C	ENST00000560464.1	-	0	4254																											CGGGAACGGGTGACTGCTTGC	0.592000													4	20					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28900176	28900176	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr16:28900176G>T	ENST00000395503.4	+	9	1181	c.997G>T	c.(997-999)Gta>Tta	p.V333L	ATP2A1_ENST00000536376.1_Missense_Mutation_p.V208L|ATP2A1_ENST00000357084.3_Missense_Mutation_p.V333L	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	333					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						GAATGCCATTGTAAGAAGCTT	0.587000													14	104					1.5842e-08	1.78644e-08	1	1	0
NCOR1P1	0	broad.mit.edu	37	20	26084296	26084296	+	RNA	SNP	A	A	G	rs61752037	by1000genomes	TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr20:26084296A>G	ENST00000478176.1	-	0	161					NR_003678.1													p.F40F(1)									GTTTGCCTCCAAATGCTGGAT	0.378000													3	56					0	0	1	0	0
HIC1	3090	broad.mit.edu	37	17	1960006	1960006	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr17:1960006C>T	ENST00000399849.2	+	2	182	c.22C>T	c.(22-24)Ccc>Tcc	p.P8S	HIC1_ENST00000322941.3_Missense_Mutation_p.P27S	NM_006497.3	NP_006488.2	Q14526	HIC1_HUMAN	hypermethylated in cancer 1	27					multicellular organismal development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|lung(1)|prostate(1)	3				READ - Rectum adenocarcinoma(1115;0.236)		GATGGAGGCGCCCGGCCACTC	0.687000													4	19					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625947	29625947	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr20:29625947T>C	ENST00000278882.3	+	5	571	c.191T>C	c.(190-192)aTt>aCt	p.I64T	FRG1B_ENST00000358464.4_Missense_Mutation_p.I64T|FRG1B_ENST00000439954.2_Missense_Mutation_p.I69T														p.I64T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCAGATGCAATTGGACCAAGA	0.343000													4	94					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143806760	143806760	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr7:143806760C>T	ENST00000408979.2	+	1	154	c.85C>T	c.(85-87)Ctc>Ttc	p.L29F		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					CCTCTGTGGACTCTTCTCTGT	0.517000													4	72					0	0	1	0	0
KRT27	342574	broad.mit.edu	37	17	38935974	38935974	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr17:38935974G>A	ENST00000301656.3	-	4	864	c.824C>T	c.(823-825)gCg>gTg	p.A275V		NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	275	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				CCAGGCCTCCGCGTCCCTGCG	0.652000													4	29					0	0	1	0	0
UTS2	10911	broad.mit.edu	37	1	7910967	7910967	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr1:7910967G>A	ENST00000377516.2	-	3	439	c.119C>T	c.(118-120)gCg>gTg	p.A40V	UTS2_ENST00000054668.5_Missense_Mutation_p.A55V|UTS2_ENST00000361696.5_Missense_Mutation_p.A40V			O95399	UTS2_HUMAN	urotensin 2	40					muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity			kidney(1)|lung(4)|urinary_tract(1)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		AGTTAAGCGCGCGTCTTCATG	0.463000													4	62					0	0	1	0	0
PHYHIPL	84457	broad.mit.edu	37	10	60996414	60996414	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr10:60996414G>A	ENST00000373880.4	+	3	739	c.475G>A	c.(475-477)Gca>Aca	p.A159T	PHYHIPL_ENST00000472199.1_3'UTR|PHYHIPL_ENST00000373878.3_Missense_Mutation_p.A133T	NM_032439.3	NP_115815.2	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein-like	159										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(3)|skin(1)|urinary_tract(1)	18						ATTCTGCACCGCAGGTAAGAG	0.328000													4	32					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137814077	137814077	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr2:137814077G>T	ENST00000409968.1	+	3	405	c.227G>T	c.(226-228)aGt>aTt	p.S76I	THSD7B_ENST00000413152.2_Missense_Mutation_p.S45I|THSD7B_ENST00000272643.3_Missense_Mutation_p.S76I					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGGTGGACAAGTCACCTGTCT	0.532000													11	25					0.000673444	0.000699854	1	1	0
OR10G8	219869	broad.mit.edu	37	11	123900679	123900679	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr11:123900679T>A	ENST00000431524.1	+	1	383	c.350T>A	c.(349-351)aTg>aAg	p.M117K		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TACAGGGTCATGTCCTGTGAT	0.557000													11	107					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141955354	141955354	+	Splice_Site	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr7:141955354C>T	ENST00000552471.1	-	2	499		c.e2+1		PRSS58_ENST00000547058.2_Splice_Site			Q8IYP2	PRS58_HUMAN	protease, serine, 58						proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						TTATCACTCACGGTAAATTGC	0.502000													9	42					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4967265	4967265	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chrY:4967265G>A	ENST00000333703.4	+	5	2126	c.1613G>A	c.(1612-1614)cGt>cAt	p.R538H	PCDH11Y_ENST00000215473.6_Missense_Mutation_p.R549H|PCDH11Y_ENST00000362095.5_Missense_Mutation_p.R549H	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	549	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						AGCCTGGATCGTCGTACAGGC	0.438000													14	11					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44673702	44673702	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr20:44673702G>T	ENST00000454036.1	+	12	1637	c.1561G>T	c.(1561-1563)Gct>Tct	p.A521S	SLC12A5_ENST00000539566.1_Intron|SLC12A5_ENST00000243964.3_Missense_Mutation_p.A498S	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	521					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CACCTGTGGGGCTGGGCTGCA	0.617000													5	99					0.217242	0.217242	1	1	0
SDE2	163859	broad.mit.edu	37	1	226182980	226182980	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr1:226182980G>A	ENST00000366817.1	-	2	234	c.71C>T	c.(70-72)gCg>gTg	p.A24V	SDE2_ENST00000272091.7_Silent_p.C75C					SDE2 telomere maintenance homolog (S. pombe)																		CTTTTCCACCGCAAAGTCTGG	0.403000													4	87					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186978566	186978566	+	Silent	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr3:186978566G>A	ENST00000337774.5	-	4	899	c.510C>T	c.(508-510)ttC>ttT	p.F170F	MASP1_ENST00000392472.2_Silent_p.F57F|MASP1_ENST00000495249.1_Intron|MASP1_ENST00000392470.2_Silent_p.F144F|MASP1_ENST00000296280.6_Silent_p.F170F|MASP1_ENST00000169293.6_Silent_p.F170F	NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	170	EGF-like; calcium-binding.|Homodimerization (By similarity).|Interaction with FCN2.|Interaction with MBL2.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		GGATGTAGCCGAAGCGGCAGG	0.527000													3	48					0	0	1	0	0
SNX2	6643	broad.mit.edu	37	5	122161782	122161782	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr5:122161782G>A	ENST00000379516.2	+	12	1358	c.1250G>A	c.(1249-1251)tGg>tAg	p.W417*	SNX2_ENST00000510372.1_3'UTR|SNX2_ENST00000514949.1_Nonsense_Mutation_p.W300*	NM_003100.2	NP_003091.2	O60749	SNX2_HUMAN	sorting nexin 2	417					cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)|skin(1)	19		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)		TGGCAGAAATGGGAAGATGCT	0.328000													5	50					0	0	1	0	0
AC024560.3	0	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	A	G	rs144273946	by1000genomes	TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr3:197348674A>G	ENST00000418868.1	-	0	585					NR_003266.2																						GGCTCTGTCCACCAAATGCAC	0.478000													5	83					0	0	1	0	0
DDX27	55661	broad.mit.edu	37	20	47850217	47850217	+	Missense_Mutation	SNP	G	G	A	rs148964696		TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr20:47850217G>A	ENST00000371764.4	+	11	1346	c.1337G>A	c.(1336-1338)cGt>cAt	p.R446H	DDX27_ENST00000484427.1_3'UTR	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	446						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CGGCCTAATCGTGAAGGAGAC	0.572000													4	62					0	0	1	0	0
NAPRT1	93100	broad.mit.edu	37	8	144658675	144658675	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr8:144658675C>T	ENST00000449291.2	-	7	1243	c.949G>A	c.(949-951)Gtg>Atg	p.V317M	RP11-661A12.9_ENST00000531730.1_RNA|NAPRT1_ENST00000426292.3_Missense_Mutation_p.V317M|NAPRT1_ENST00000276844.7_Missense_Mutation_p.V317M|NAPRT1_ENST00000435154.3_Missense_Mutation_p.V317M			Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain containing 1	317					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			endometrium(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	6	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TCCAGCCTCACGCCCACTGCC	0.627000													5	10					0	0	1	0	0
DEFB129	140881	broad.mit.edu	37	20	210386	210386	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr20:210386G>T	ENST00000246105.4	+	2	557	c.526G>T	c.(526-528)Gag>Tag	p.E176*		NM_080831.3	NP_543021.1	Q9H1M3	DB129_HUMAN	defensin, beta 129	176					defense response to bacterium	extracellular region				endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(1)|ovary(1)|stomach(1)	9		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			ACCATCACTGGAGCTAGAGGA	0.443000													5	29					2.0095e-06	2.17354e-06	1	1	0
RAB11FIP4	84440	broad.mit.edu	37	17	29850576	29850576	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr17:29850576G>A	ENST00000325874.8	+	8	1205	c.976G>A	c.(976-978)Gaa>Aaa	p.E326K	RAB11FIP4_ENST00000394744.2_Missense_Mutation_p.E224K	NM_032932.3	NP_116321.2	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	326	Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				TGGCAGCACCGAAGACCTGTT	0.607000													4	57					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51375588	51375588	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr14:51375588G>T	ENST00000216392.7	-	18	2595	c.2263C>A	c.(2263-2265)Cag>Aag	p.Q755K	PYGL_ENST00000544180.2_Missense_Mutation_p.Q721K|PYGL_ENST00000532462.1_Missense_Mutation_p.Q755K	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	755					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	AGGTCAGGCTGCTTGGGAGAA	0.438000													4	103					0.150653	0.153551	1	1	0
NCR3	259197	broad.mit.edu	37	6	31557641	31557641	+	Silent	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr6:31557641G>A	ENST00000376073.4	-	2	569	c.306C>T	c.(304-306)gaC>gaT	p.D102D	NCR3_ENST00000491161.1_5'UTR|NCR3_ENST00000340027.5_Silent_p.D102D|NCR3_ENST00000376071.4_Silent_p.D77D|NCR3_ENST00000376072.3_Silent_p.D102D	NM_001145466.1	NP_001138938.1	O14931	NCTR3_HUMAN	natural cytotoxicity triggering receptor 3	102	Ig-like.				cell recognition|immune response|inflammatory response|positive regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane	receptor activity	p.D102E(1)		cervix(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)	9						AGATGCTGGCGTCATGGCCTC	0.632000													4	57					0	0	1	0	0
HOXB4	3214	broad.mit.edu	37	17	46655387	46655387	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr17:46655387C>T	ENST00000332503.5	-	1	2086	c.295G>A	c.(295-297)Gcc>Acc	p.A99T	HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Intron|HOXB3_ENST00000489475.1_Intron|HOXB3_ENST00000465120.3_Intron|HOXB3_ENST00000552000.2_Intron|HOXB3_ENST00000498678.1_Intron|HOXB3_ENST00000476342.1_Intron|HOXB3_ENST00000472863.1_Intron	NM_024015.4	NP_076920.1	P17483	HXB4_HUMAN	homeobox B4	99	Pro-rich (part of the transcriptional activation domain).					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	9						AGGGCCCCGGCGGGTGGCGGC	0.836000													2	1					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76022259	76022259	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr6:76022259C>T	ENST00000393004.2	-	5	3510	c.3289G>A	c.(3289-3291)Gtg>Atg	p.V1097M	FILIP1_ENST00000370020.1_Missense_Mutation_p.V998M|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.V1097M			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	1097										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TCGGCTGTCACGTTTACTGGT	0.512000													5	99					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6718310	6718310	+	Silent	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr19:6718310G>A	ENST00000245907.6	-	3	473	c.381C>T	c.(379-381)agC>agT	p.S127S		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	127					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		AGAGGTACCCGCTCTGCAGGC	0.647000													4	22					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67914636	67914636	+	Silent	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr16:67914636C>T	ENST00000358933.5	+	18	2513	c.2274C>T	c.(2272-2274)tcC>tcT	p.S758S		NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	758					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		GTTTTGGCTCCTCTGCACCAG	0.662000													10	134					0	0	1	0	0
POLG	5428	broad.mit.edu	37	15	89860013	89860013	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr15:89860013G>A	ENST00000268124.5	-	23	4022	c.3689C>T	c.(3688-3690)tCc>tTc	p.S1230F	FANCI_ENST00000300027.8_3'UTR|POLG_ENST00000442287.2_Missense_Mutation_p.S1230F|FANCI_ENST00000310775.7_3'UTR	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	1230					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			TTTTTCCAAGGAGCCTTTGGT	0.507000								DNA polymerases (catalytic subunits)					6	55					0	0	1	0	0
PRR3	80742	broad.mit.edu	37	6	30525976	30525976	+	Silent	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr6:30525976C>T	ENST00000376560.3	+	2	615	c.156C>T	c.(154-156)ggC>ggT	p.G52G	PRR3_ENST00000498336.1_3'UTR|PRR3_ENST00000376557.3_Intron	NM_025263.3	NP_079539.2	P79522	PRR3_HUMAN	proline rich 3	52	Pro-rich.						nucleic acid binding|zinc ion binding			lung(1)|ovary(1)	2						GAAAACCTGGCGACCCTAAGT	0.502000													6	32					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	236966820	236966820	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr1:236966820C>T	ENST00000366577.5	+	2	521	c.127C>T	c.(127-129)Cgg>Tgg	p.R43W	MTR_ENST00000535889.1_Missense_Mutation_p.R43W|MTR_ENST00000418145.2_Intron	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	43	Hcy-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	CATGATCCAGCGGGAGAAGCT	0.468000													3	55					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58232392	58232392	+	Silent	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr19:58232392G>A	ENST00000317398.6	-	4	1157	c.1062C>T	c.(1060-1062)tcC>tcT	p.S354S	AC003006.7_ENST00000599221.1_Intron|ZNF671_ENST00000335820.3_Silent_p.S256S	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	354					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CAATCAGGCCGGAGATTTGTC	0.453000													4	61					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	50					0	0	1	0	0
CTC-467M3.1	0	broad.mit.edu	37	5	87980831	87980831	+	RNA	DEL	G	G	-			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr5:87980831delG	ENST00000510274.1	+	0	46																											aggaggaggaggGATGGGAGG	0.587													2	4	---	---	---	---					
TMEM151A	256472	broad.mit.edu	37	11	66063023	66063023	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZG-A9L4-01A-11D-A41K-08	TCGA-ZG-A9L4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7d643e8-1bc8-4a0d-af31-ca9f06243547	c35ccd5c-e37d-41c1-9ebf-b805bc3cfa63	g.chr11:66063023delC	ENST00000327259.4	+	2	1450	c.1306delC	c.(1306-1308)ccfs	p.P436fs		NM_153266.3	NP_694998.1	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	436						integral to membrane				central_nervous_system(1)|kidney(4)|lung(6)	11						GGACACGGAACCCCTGGAGAG	0.731													2	4	---	---	---	---					
