Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
EML5	161436	broad.mit.edu	37	14	89154654	89154654	+	Silent	SNP	C	C	T	rs118043831	by1000genomes	TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr14:89154654C>T	ENST00000554922.1	-	18	2951	c.2703G>A	c.(2701-2703)gcG>gcA	p.A901A	EML5_ENST00000352093.5_Silent_p.A863A|EML5_ENST00000380664.5_Silent_p.A901A	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	901						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GCCCATCATGCGCTTTCACTG	0.388000													4	214					0	0	1	0	0
EARS2	124454	broad.mit.edu	37	16	23544062	23544062	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr16:23544062G>A	ENST00000449606.1	-	5	1014	c.983C>T	c.(982-984)cCg>cTg	p.P328L	EARS2_ENST00000563459.1_Missense_Mutation_p.P328L|EARS2_ENST00000564987.1_5'UTR|EARS2_ENST00000563232.1_Missense_Mutation_p.P328L|EARS2_ENST00000564501.1_Missense_Mutation_p.P328L	NM_001083614.1	NP_001077083.1	Q5JPH6	SYEM_HUMAN	glutamyl-tRNA synthetase 2, mitochondrial	328					glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding			central_nervous_system(1)|endometrium(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	8				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)	GATCAGCTCCGGCAGGGTCCT	0.532000													8	31					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76237544	76237544	+	Silent	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr11:76237544G>A	ENST00000529032.1	+	12	1860	c.1860G>A	c.(1858-1860)aaG>aaA	p.K620K	C11orf30_ENST00000524490.1_Silent_p.K536K|C11orf30_ENST00000533248.1_Silent_p.K634K|C11orf30_ENST00000525038.1_Silent_p.K635K|C11orf30_ENST00000524767.1_Silent_p.K635K|C11orf30_ENST00000525919.1_Silent_p.K621K|C11orf30_ENST00000334736.3_Silent_p.K620K|C11orf30_ENST00000343878.3_Silent_p.K620K			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	620	Thr-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						CAGGAGCAAAGCCAGCTATCC	0.378000													5	51					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72039275	72039275	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr15:72039275T>C	ENST00000355327.3	+	13	2269	c.2135T>C	c.(2134-2136)cTg>cCg	p.L712P	THSD4_ENST00000567838.1_3'UTR|THSD4_ENST00000261862.6_Missense_Mutation_p.L712P|THSD4_ENST00000357769.4_Missense_Mutation_p.L352P			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	712	TSP type-1 2.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						AACCGCAGCCTGACGGTGCAG	0.642000													7	28					0	0	1	0	0
EIF5	1983	broad.mit.edu	37	14	103806053	103806053	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr14:103806053G>C	ENST00000216554.3	+	10	1660	c.984G>C	c.(982-984)caG>caC	p.Q328H	EIF5_ENST00000558506.1_Missense_Mutation_p.Q328H|EIF5_ENST00000392715.2_Missense_Mutation_p.Q328H	NM_001969.4	NP_001960.2	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	328	W2.				regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			breast(3)|kidney(2)|large_intestine(3)|lung(5)|pancreas(2)|skin(2)|upper_aerodigestive_tract(1)	18		Melanoma(154;0.155)	Epithelial(46;0.182)			ATCAAGCTCAGCTTATCTCCA	0.433000													8	42					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	23					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201185695	201185695	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr1:201185695G>A	ENST00000335211.4	+	16	9539	c.9409G>A	c.(9409-9411)Gtg>Atg	p.V3137M	IGFN1_ENST00000295591.8_Missense_Mutation_p.V297M	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						AGAGTGCTACGTGGTGGAGAG	0.667000													3	20					0	0	1	0	0
MALAT1	0	broad.mit.edu	37	11	65273824	65273824	+	RNA	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr11:65273824G>A	ENST00000534336.1	+	0	8592					NR_002819.2																						ATATTTACACGAGAACCTAAT	0.363000													4	18					0	0	1	0	0
PAX7	5081	broad.mit.edu	37	1	18961619	18961619	+	Silent	SNP	G	G	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr1:18961619G>T	ENST00000420770.2	+	3	419	c.336G>T	c.(334-336)ccG>ccT	p.P112P	PAX7_ENST00000400661.3_Silent_p.P112P|PAX7_ENST00000375375.3_Silent_p.P112P	NM_001135254.1	NP_001128726.1	P23759	PAX7_HUMAN	paired box 7	112	Paired.				anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		TGGCGACTCCGGATGTAGAGA	0.522000			T	FOXO1A	alveolar rhabdomyosarcoma								3	50					0.00024832	0.000266714	1	1	0
AKR1A1	10327	broad.mit.edu	37	1	46032655	46032655	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr1:46032655C>G	ENST00000372070.3	+	5	1066	c.319C>G	c.(319-321)Ctg>Gtg	p.L107V	AKR1A1_ENST00000351829.4_Missense_Mutation_p.L107V|AKR1A1_ENST00000471651.1_3'UTR	NM_001202413.1|NM_001202414.1|NM_006066.3	NP_001189342.1|NP_001189343.1|NP_006057.1	P14550	AK1A1_HUMAN	aldo-keto reductase family 1, member A1 (aldehyde reductase)	107					glucose metabolic process		alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			lung(3)|prostate(1)|urinary_tract(1)	5	Acute lymphoblastic leukemia(166;0.155)					GCTGGAGTATCTGGACCTGTA	0.562000													6	60					0	0	1	0	0
NSMCE2	286053	broad.mit.edu	37	8	126163474	126163474	+	Silent	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr8:126163474G>A	ENST00000287437.3	+	4	435	c.219G>A	c.(217-219)cgG>cgA	p.R73R	NSMCE2_ENST00000517315.1_Silent_p.R13R|NSMCE2_ENST00000522563.1_Silent_p.R73R	NM_173685.2	NP_775956.1	Q96MF7	NSE2_HUMAN	non-SMC element 2, MMS21 homolog (S. cerevisiae)	73					DNA recombination|DNA repair	nucleus	ligase activity|zinc ion binding			breast(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(2)	9	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			CATTGGATCGGCAACTAAACC	0.328000													4	219					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28194061	28194061	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr22:28194061C>A	ENST00000302326.4	-	1	3425	c.2471G>T	c.(2470-2472)tGc>tTc	p.C824F		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	824							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						CGCAGCCAGGCAGCTCTGGCC	0.632000			T	ETV6	"""AML, meningioma"""								11	73					3.07112e-06	3.36085e-06	1	1	0
LINGO4	339398	broad.mit.edu	37	1	151773576	151773576	+	Silent	SNP	C	C	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr1:151773576C>T	ENST00000368820.3	-	2	2542	c.1605G>A	c.(1603-1605)gtG>gtA	p.V535V		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	535						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CGACTGCCAGCACCATGGCCA	0.567000													20	121					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49005949	49005949	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr4:49005949A>G	ENST00000226432.4	+	7	1183	c.1000A>G	c.(1000-1002)Aca>Gca	p.T334A	CWH43_ENST00000513409.1_Missense_Mutation_p.T307A	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	334					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						TGCCTGGTGCACAGCTTTTAA	0.398000													5	34					0	0	1	0	0
PRPSAP2	5636	broad.mit.edu	37	17	18833976	18833976	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr17:18833976T>A	ENST00000268835.2	+	12	1358	c.1075T>A	c.(1075-1077)Tcc>Acc	p.S359T	PRPSAP2_ENST00000536323.1_Missense_Mutation_p.S273T|PRPSAP2_ENST00000419071.2_Missense_Mutation_p.S319T|PRPSAP2_ENST00000542013.1_Missense_Mutation_p.S310T	NM_002767.3	NP_002758.1	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate synthetase-associated protein 2	359					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11						GGAGTCCATGTCCTACCTTTT	0.478000													10	58					0	0	1	0	0
RP11-1407O15.2	0	broad.mit.edu	37	17	36357265	36357265	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr17:36357265C>T	ENST00000312412.4	-	9	987	c.988G>A	c.(988-990)Gca>Aca	p.A330T	RP11-1407O15.2_ENST00000544906.1_Missense_Mutation_p.A175T|TBC1D3_ENST00000537432.1_5'UTR																kidney(1)|lung(3)	4						ATAAGCAATGCAGTCTCCCTA	0.378000													4	49					0	0	1	0	0
CD72	971	broad.mit.edu	37	9	35616600	35616600	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr9:35616600G>A	ENST00000396757.1	-	5	513	c.349C>T	c.(349-351)Cgc>Tgc	p.R117C	CD72_ENST00000259633.4_Missense_Mutation_p.R117C|CD72_ENST00000490239.1_5'UTR|CD72_ENST00000378431.1_Missense_Mutation_p.R117C			P21854	CD72_HUMAN	CD72 molecule	117					axon guidance|cell adhesion	integral to plasma membrane	receptor binding|sugar binding|transmembrane receptor activity			large_intestine(5)|liver(1)|lung(6)	12			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TACTCACAGCGCACTCCCAGG	0.592000													8	36					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33276241	33276241	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr1:33276241G>A	ENST00000373477.4	-	3	1239	c.331C>T	c.(331-333)Ccc>Tcc	p.P111S		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	111					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	TTCTCCAAGGGCACACCAATG	0.473000													3	58					0	0	1	0	0
MBL2	4153	broad.mit.edu	37	10	54531228	54531228	+	Silent	SNP	C	C	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr10:54531228C>T	ENST00000373968.3	-	1	232	c.168G>A	c.(166-168)aaG>aaA	p.K56K		NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	56	Collagen-like.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						CCTTTTCTCCCTTGGTGCCAT	0.542000													3	29					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3643249	3643249	+	Silent	SNP	C	C	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr19:3643249C>T	ENST00000335312.3	-	13	1729	c.1641G>A	c.(1639-1641)ccG>ccA	p.P547P	PIP5K1C_ENST00000539785.1_Silent_p.P547P|PIP5K1C_ENST00000537021.1_Silent_p.P547P|PIP5K1C_ENST00000589578.1_Silent_p.P547P	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	547					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		ACCTGTACCGCGGCTGCTCCG	0.652000													6	50					0	0	1	0	0
MLXIPL	51085	broad.mit.edu	37	7	73010746	73010746	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr7:73010746C>G	ENST00000313375.3	-	12	1933	c.1886G>C	c.(1885-1887)cGt>cCt	p.R629P	MLXIPL_ENST00000429400.2_Missense_Mutation_p.R629P|MLXIPL_ENST00000434326.1_Missense_Mutation_p.R535P|MLXIPL_ENST00000414749.2_Missense_Mutation_p.R629P|MLXIPL_ENST00000395189.1_Missense_Mutation_p.R536P|MLXIPL_ENST00000354613.1_Missense_Mutation_p.R629P	NM_032951.2|NM_032953.2	NP_116569.1|NP_116571.1	Q9NP71	WBS14_HUMAN	MLX interacting protein-like	629					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			cervix(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13		Lung NSC(55;0.0659)|all_lung(88;0.152)				GGGAGAGACACGGACGCTCAG	0.652000													6	62					0	0	1	0	0
PIGT	51604	broad.mit.edu	37	20	44054316	44054316	+	Silent	SNP	C	C	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr20:44054316C>A	ENST00000279036.6	+	12	1667	c.1587C>A	c.(1585-1587)atC>atA	p.I529I	PIGT_ENST00000545755.1_Silent_p.I267I|PIGT_ENST00000341555.5_Silent_p.I335I|PIGT_ENST00000535404.1_Silent_p.I374I|PIGT_ENST00000543458.2_Silent_p.I473I|PIGT_ENST00000279035.9_Silent_p.I427I|PIGT_ENST00000372689.5_Silent_p.I462I	NM_015937.5	NP_057021.2	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class T	529					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(1)|endometrium(2)|kidney(5)|large_intestine(4)|lung(7)|pancreas(1)|skin(1)|stomach(1)	22		Myeloproliferative disorder(115;0.0122)				ACAACGTGATCTGCCTCACGT	0.597000													3	26					0.115264	0.115264	1	1	0
TUBGCP4	27229	broad.mit.edu	37	15	43669217	43669217	+	Silent	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr15:43669217G>A	ENST00000564079.1	+	4	576	c.336G>A	c.(334-336)ctG>ctA	p.L112L	TUBGCP4_ENST00000260383.7_Silent_p.L112L|TUBGCP4_ENST00000399460.3_5'UTR	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	112					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		TGCAGTTCCTGGGTGATCCCC	0.378000													8	45					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79945312	79945312	+	Silent	SNP	A	A	G			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chrX:79945312A>G	ENST00000373275.4	-	33	3978	c.3762T>C	c.(3760-3762)taT>taC	p.Y1254Y	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1254										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						TAATTTTATTATAAGTATCCA	0.289000													3	11					0	0	1	0	0
PCDHA9	0	broad.mit.edu	37	5	140229383	140229383	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr5:140229383C>G	ENST00000378122.3	+	1	2027	c.1303C>G	c.(1303-1305)Ctg>Gtg	p.L435V	PCDHA9_ENST00000532602.1_Missense_Mutation_p.L435V|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCGCCTTCACTGTGGGCCAC	0.622000													14	132					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454624	84454624	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr13:84454624G>T	ENST00000377084.2	-	1	1904	c.1019C>A	c.(1018-1020)cCc>cAc	p.P340H		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	340	LRRNT 2.					integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CCCAGGGCAGGGTAAACTGTT	0.542000													8	106					0.0477658	0.0486038	1	1	0
TNKS2	80351	broad.mit.edu	37	10	93590737	93590737	+	Silent	SNP	A	A	C			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr10:93590737A>C	ENST00000371627.4	+	10	1541	c.1162A>C	c.(1162-1164)Aga>Cga	p.R388R		NM_025235.3	NP_079511.1	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	388					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			biliary_tract(1)|breast(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	48		Colorectal(252;0.162)				ACTGTTGCTAAGAAAAGGAGC	0.294000													5	28					0	0	1	0	0
CELF2	10659	broad.mit.edu	37	10	11312644	11312644	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr10:11312644A>G	ENST00000379261.4	+	7	705	c.613A>G	c.(613-615)Atc>Gtc	p.I205V	CELF2_ENST00000399850.3_Missense_Mutation_p.I181V|CELF2_ENST00000416382.2_Missense_Mutation_p.I205V|CELF2_ENST00000542579.1_Missense_Mutation_p.I212V|CELF2_ENST00000315874.3_Missense_Mutation_p.I181V|CELF2_ENST00000427450.1_Missense_Mutation_p.I181V|CELF2_ENST00000537122.1_Missense_Mutation_p.I94V|CELF2_ENST00000354897.3_Missense_Mutation_p.I181V|CELF2_ENST00000417956.2_Missense_Mutation_p.I181V|CELF2_ENST00000354440.2_Missense_Mutation_p.I181V|CELF2_ENST00000450189.1_Missense_Mutation_p.I212V	NM_001025077.2	NP_001020248.1	O95319	CELF2_HUMAN	CUGBP, Elav-like family member 2	205	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.|RRM 2.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	16						CTCTTCACCTATCGTGGTGAA	0.577000											OREG0020007	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	54					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55579364	55579364	+	Missense_Mutation	SNP	G	G	A	rs138368201		TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr11:55579364G>A	ENST00000333973.2	+	1	511	c.422G>A	c.(421-423)cGt>cAt	p.R141H		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R141H(2)		NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TGGAAGGTGCGTGTGGAGCTG	0.498000													9	85					0	0	1	0	0
OR10G3	26533	broad.mit.edu	37	14	22038732	22038732	+	Silent	SNP	A	A	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr14:22038732A>T	ENST00000303532.1	-	1	143	c.144T>A	c.(142-144)acT>acA	p.T48T		NM_001005465.1	NP_001005465.1	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G, member 3	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)	15	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		CTGCCCAGACAGTGATTAAAA	0.468000													3	28					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233393299	233393299	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr2:233393299C>T	ENST00000258385.3	+	5	474	c.442C>T	c.(442-444)Cgc>Tgc	p.R148C	CHRND_ENST00000457943.2_Silent_p.S57S|CHRND_ENST00000543200.1_Missense_Mutation_p.R133C|CHRND_ENST00000536614.1_Missense_Mutation_p.R148C	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	148					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		TGCCATCTTCCGCTCCTCCTG	0.587000													4	125					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38159066	38159066	+	Splice_Site	SNP	C	C	G			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr13:38159066C>G	ENST00000379747.4	-	8	1013		c.e8-1		POSTN_ENST00000541179.1_Splice_Site|POSTN_ENST00000379742.4_Splice_Site|POSTN_ENST00000379749.4_Splice_Site|POSTN_ENST00000541481.1_Splice_Site|POSTN_ENST00000379743.4_Splice_Site	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor						cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TTCATAAGAGCTGGAGAACAC	0.383000													3	26					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209773408	209773408	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr1:209773408C>A	ENST00000009105.1	+	3	418	c.173C>A	c.(172-174)cCt>cAt	p.P58H	CAMK1G_ENST00000361322.2_Missense_Mutation_p.P58H			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	58	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		AAGAAGTCACCTGCCTTCCGG	0.463000													8	44					0.000274275	0.000289236	1	1	0
SPOP	8405	broad.mit.edu	37	17	47696432	47696432	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr17:47696432A>G	ENST00000393331.3	-	7	861	c.391T>C	c.(391-393)Tgg>Cgg	p.W131R	SPOP_ENST00000347630.2_Missense_Mutation_p.W131R|SPOP_ENST00000504102.1_Missense_Mutation_p.W131R|SPOP_ENST00000393328.2_Missense_Mutation_p.W131R|SPOP_ENST00000503676.1_Missense_Mutation_p.W131R	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	131	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.W131G(2)|p.W131R(1)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						TTGAATCCCCAGTCTTTGCCT	0.458000										Prostate(2;0.17)			18	98					0	0	1	0	0
RHOA	387	broad.mit.edu	37	3	49412958	49412958	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr3:49412958A>C	ENST00000418115.1	-	2	449	c.65T>G	c.(64-66)cTc>cGc	p.L22R	RHOA_ENST00000454011.2_Missense_Mutation_p.L22R|RHOA_ENST00000422781.1_Missense_Mutation_p.L22R	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	22					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	GAAGACTATGAGCAAGCATGT	0.473000													17	90					0	0	1	0	0
SOX9	6662	broad.mit.edu	37	17	70119078	70119078	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr17:70119078G>A	ENST00000245479.2	+	2	1022	c.650G>A	c.(649-651)gGc>gAc	p.G217D		NM_000346.3	NP_000337.1	P48436	SOX9_HUMAN	SRY (sex determining region Y)-box 9	217					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(5)|pancreas(1)|upper_aerodigestive_tract(2)	26		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			TCCTCCTCCGGCATGAGCGAG	0.697000													4	110					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111397722	111397722	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr4:111397722C>T	ENST00000265162.5	+	1	494	c.152C>T	c.(151-153)cCg>cTg	p.P51L		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	51					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GACGGCGGGCCGGGCACTGCG	0.647000													8	72					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	C	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr2:197657782C>T	ENST00000263956.3	-	3	398	c.309G>A	c.(307-309)gaG>gaA	p.E103E	GTF3C3_ENST00000409364.3_Silent_p.E103E	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding	p.E103E(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						cctcctcctcctcttcttcct	0.468000													3	69					0	0	1	0	0
ELMO2	63916	broad.mit.edu	37	20	45003941	45003941	+	Silent	SNP	G	G	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr20:45003941G>T	ENST00000372176.1	-	13	1203	c.735C>A	c.(733-735)gcC>gcA	p.A245A	ELMO2_ENST00000488853.1_5'UTR|ELMO2_ENST00000439931.2_Silent_p.A345A|ELMO2_ENST00000454865.2_Silent_p.A65A|ELMO2_ENST00000445496.2_Silent_p.A150A|ELMO2_ENST00000396391.1_Silent_p.A333A|ELMO2_ENST00000290246.6_Silent_p.A333A|ELMO2_ENST00000352077.2_Silent_p.A331A			Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	333					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|urinary_tract(1)	16		Myeloproliferative disorder(115;0.0122)				CACTCCCAGGGGCATTGCTAG	0.498000													6	50					2.0095e-06	2.28531e-06	1	1	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	29					0	0	1	0	0
FUT8	2530	broad.mit.edu	37	14	66083072	66083072	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr14:66083072G>A	ENST00000360689.5	+	5	2190	c.463G>A	c.(463-465)Gat>Aat	p.D155N	FUT8_ENST00000358307.2_5'UTR|FUT8_ENST00000394586.2_Missense_Mutation_p.D155N|FUT8_ENST00000557164.1_5'UTR|FUT8_ENST00000394585.1_Missense_Mutation_p.D155N	NM_004480.4|NM_178155.2	NP_004471.4|NP_835368.1	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	155					in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		ATTTCTTTTGGATTTAGGACA	0.328000													9	63					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21689273	21689273	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr20:21689273C>T	ENST00000398485.2	+	3	1048	c.994C>T	c.(994-996)Ccc>Tcc	p.P332S	PAX1_ENST00000460221.1_3'UTR|PAX1_ENST00000444366.2_Missense_Mutation_p.P308S	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	332					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						CACGGCCTTCCCCGCCACCCC	0.602000													6	74					0	0	1	0	0
PPIL4	85313	broad.mit.edu	37	6	149826699	149826699	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr6:149826699G>A	ENST00000253329.2	-	13	1401	c.1369C>T	c.(1369-1371)Cat>Tat	p.H457Y	PPIL4_ENST00000340881.2_Silent_p.V89V	NM_139126.3	NP_624311.1	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 4	457					protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding			endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	13		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		TTTGATTTATGACTATTACTA	0.383000													12	71					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136573529	136573529	+	Silent	SNP	C	C	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr9:136573529C>T	ENST00000371872.4	-	11	1607	c.1350G>A	c.(1348-1350)acG>acA	p.T450T	SARDH_ENST00000422262.2_Silent_p.T282T|SARDH_ENST00000439388.1_Silent_p.T450T	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	450					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GGGGGTGGTCCGTGAGCGAGT	0.652000													17	75					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216138762	216138762	+	Silent	SNP	T	T	C			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr1:216138762T>C	ENST00000366943.2	-	37	7403	c.7017A>G	c.(7015-7017)acA>acG	p.T2339T	USH2A_ENST00000307340.3_Silent_p.T2339T			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2339	Fibronectin type-III 10.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGGATCCCTGTGTTTTGACAA	0.413000										HNSCC(13;0.011)			14	102					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9107756	9107756	+	Missense_Mutation	SNP	C	C	T	rs138176474	byFrequency	TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr1:9107756C>T	ENST00000377424.4	-	4	510	c.331G>A	c.(331-333)Gtg>Atg	p.V111M	SLC2A5_ENST00000536305.1_Missense_Mutation_p.V52M|SLC2A5_ENST00000377414.3_Missense_Mutation_p.V111M|SLC2A5_ENST00000535586.1_De_novo_Start_InFrame	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	111					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		ATCGCAGGCACGATAGAAAAT	0.393000													13	104					0	0	1	0	0
COLEC11	78989	broad.mit.edu	37	2	3691463	3691463	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr2:3691463G>A	ENST00000403096.3	+	6	984	c.493G>A	c.(493-495)Gca>Aca	p.A165T	COLEC11_ENST00000487365.1_3'UTR|COLEC11_ENST00000382062.2_Missense_Mutation_p.A167T|COLEC11_ENST00000349077.4_Missense_Mutation_p.A191T|COLEC11_ENST00000236693.7_Missense_Mutation_p.A188T|COLEC11_ENST00000402794.1_Missense_Mutation_p.A141T|COLEC11_ENST00000418971.2_Missense_Mutation_p.A205T|COLEC11_ENST00000404205.1_Missense_Mutation_p.A117T|COLEC11_ENST00000402922.1_Missense_Mutation_p.A141T	NM_001255986.1	NP_001242915.1	Q9BWP8	COL11_HUMAN	collectin sub-family member 11	191	C-type lectin.					collagen	mannose binding	p.A205T(1)|p.A188T(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|soft_tissue(1)	22	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		CCTGATGGCCGCATACCTGGC	0.672000													3	29					0	0	1	0	0
TMEM150B	284417	broad.mit.edu	37	19	55824409	55824409	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr19:55824409C>T	ENST00000326652.4	-	8	702	c.520G>A	c.(520-522)Gcc>Acc	p.A174T	TMEM150B_ENST00000438693.1_Missense_Mutation_p.A174T			A6NC51	T150B_HUMAN	transmembrane protein 150B	174						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3						AGCGAGCAGGCGTGGAGGACG	0.682000													4	17					0	0	1	0	0
SDSL	113675	broad.mit.edu	37	12	113875804	113875804	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr12:113875804G>A	ENST00000403593.4	+	8	1172	c.910G>A	c.(910-912)Gtt>Att	p.V304I	SDSL_ENST00000345635.4_Missense_Mutation_p.V304I			Q96GA7	SDSL_HUMAN	serine dehydratase-like	304					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	15					Pyridoxal Phosphate(DB00114)	CCTGACTTCAGTTGTGGTAAT	0.632000													25	169					0	0	1	0	0
AK3	50808	broad.mit.edu	37	9	4722560	4722560	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr9:4722560G>A	ENST00000381809.3	-	2	447	c.217C>T	c.(217-219)Cgg>Tgg	p.R73W	AK3_ENST00000447596.4_Intron|AK3_ENST00000359883.2_Missense_Mutation_p.R3W	NM_016282.3	NP_057366.2	Q9UIJ7	KAD3_HUMAN	adenylate kinase 3	73					blood coagulation	mitochondrial matrix	ATP binding|GTP binding|nucleoside triphosphate adenylate kinase activity			large_intestine(2)|lung(1)|ovary(2)	5	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0302)		AGGGCCAGCCGAGTCATGACA	0.463000													3	46					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142699964	142699965	+	RNA	INS	-	-	ATC	rs74315780		TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr1:142699964_142699965insATC	ENST00000369381.2	-	0	2077																											atatatatatatCCAAAATATA	0.262													2	4	---	---	---	---					
HDAC2	3066	broad.mit.edu	37	6	114292110	114292112	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr6:114292110_114292112delCTG	ENST00000398283.2	-	1	247_249	c.243_245delCAG	c.(241-246)agg>ag	p.SR81del	RP3-399L15.3_ENST00000520554.1_RNA|RP3-399L15.3_ENST00000519104.1_RNA|HDAC2_ENST00000368632.2_5'UTR|RP3-399L15.3_ENST00000449620.2_RNA|RP3-399L15.3_ENST00000436876.2_RNA|HDAC2_ENST00000519065.1_5'UTR	NM_001527.3	NP_001518.3	Q92769	HDAC2_HUMAN	histone deacetylase 2	0	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding	p.S81R(1)		biliary_tract(1)|central_nervous_system(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	GCTCCTCCTCctgctgctgctgc	0.685													2	4	---	---	---	---					
TPCN1	53373	broad.mit.edu	37	12	113704096	113704098	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr12:113704096_113704098delCTG	ENST00000550785.1	+	5	734_736	c.565_567delCTG	c.(565-567)del	p.L194del	TPCN1_ENST00000392569.4_In_Frame_Del_p.L54del|TPCN1_ENST00000541517.1_In_Frame_Del_p.L194del|TPCN1_ENST00000335509.6_In_Frame_Del_p.L122del	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	122						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						GGCCACGGCCCTGCTGCTGCTGC	0.640													8	343	---	---	---	---					
TANGO2	128989	broad.mit.edu	37	22	20049058	20049058	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZG-A9L6-01A-11D-A41K-08	TCGA-ZG-A9L6-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26e0ebbb-acc0-42da-8ba0-893de310f978	4b775aa7-c03d-4cb8-8eb1-7dfe3aa2417a	g.chr22:20049058delT	ENST00000327374.4	+	7	635	c.457delT	c.(457-459)acfs	p.Y153fs	TANGO2_ENST00000420290.2_Frame_Shift_Del_p.Y55fs|TANGO2_ENST00000401833.1_Frame_Shift_Del_p.Y194fs|TANGO2_ENST00000401886.1_Frame_Shift_Del_p.Y91fs|TANGO2_ENST00000398042.2_Frame_Shift_Del_p.Y91fs|TANGO2_ENST00000456048.1_Frame_Shift_Del_p.Y158fs|TANGO2_ENST00000447208.2_Frame_Shift_Del_p.Y153fs|TANGO2_ENST00000434570.2_Intron|TANGO2_ENST00000432883.1_Frame_Shift_Del_p.Y91fs	NM_152906.4	NP_690870.3			transport and golgi organization 2 homolog (Drosophila)																		CACAGGCACCTACGGGCTGAG	0.632													2	4	---	---	---	---					
