Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ABCA13	154664	broad.mit.edu	37	7	48321025	48321025	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr7:48321025G>A	ENST00000435803.1	+	19	8836	c.8812G>A	c.(8812-8814)Gta>Ata	p.V2938I		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2938					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GATGATGGTCGTACGTGTGCT	0.463000													4	10					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79434626	79434626	+	Missense_Mutation	SNP	C	C	T	rs140301017		TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr14:79434626C>T	ENST00000554719.1	+	11	2451	c.1960C>T	c.(1960-1962)Cgc>Tgc	p.R654C	NRXN3_ENST00000335750.5_Missense_Mutation_p.R654C	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	260					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CTTGAATGGACGCCTGCCAGA	0.522000													18	34					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158223441	158223441	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr5:158223441G>A	ENST00000313708.6	-	9	1103	c.821C>T	c.(820-822)aCg>aTg	p.T274M	EBF1_ENST00000518836.1_5'UTR|EBF1_ENST00000517373.1_Missense_Mutation_p.T266M|EBF1_ENST00000380654.4_Missense_Mutation_p.T243M	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	274	IPT/TIG.				multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACCTCCCGTCGTCCATCCTTC	0.468000			T	HMGA2	lipoma								22	51					0	0	1	0	0
MBD5	0	broad.mit.edu	37	2	149221402	149221402	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr2:149221402G>A	ENST00000407073.1	+	8	1308	c.311G>A	c.(310-312)aGa>aAa	p.R104K	MBD5_ENST00000404807.1_Missense_Mutation_p.R104K	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	104						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ATACATAAAAGAAAAATTATT	0.428000													26	33					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78351638	78351638	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr5:78351638C>A	ENST00000255189.3	-	3	398	c.370G>T	c.(370-372)Ggt>Tgt	p.G124C	DMGDH_ENST00000540686.1_Intron|DMGDH_ENST00000380311.4_Intron	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	124					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TTTACCTGACCAGTTTCTTCT	0.348000													4	15					0.150653	0.150653	1	1	0
CACNA1E	777	broad.mit.edu	37	1	181702679	181702679	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr1:181702679G>A	ENST00000526775.1	+	20	3163	c.2998G>A	c.(2998-3000)Gtg>Atg	p.V1000M	CACNA1E_ENST00000367573.2_Missense_Mutation_p.V1019M|CACNA1E_ENST00000367570.1_Missense_Mutation_p.V1019M|CACNA1E_ENST00000358338.5_Missense_Mutation_p.V951M|CACNA1E_ENST00000367567.4_Missense_Mutation_p.V626M|CACNA1E_ENST00000357570.5_Missense_Mutation_p.V970M|CACNA1E_ENST00000360108.3_Missense_Mutation_p.V1000M	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1019					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.V1019M(1)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GGGGAAGCACGTGGTGCTGAC	0.642000													15	20					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6197460	6197460	+	Silent	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr6:6197460G>A	ENST00000264870.3	-	9	1477	c.1212C>T	c.(1210-1212)agC>agT	p.S404S		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	404					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TTTTACCATCGCTATTTTCCT	0.502000													4	40					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653362	159653362	+	Silent	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr6:159653362G>A	ENST00000297267.9	+	11	2018	c.1818G>A	c.(1816-1818)acG>acA	p.T606T	FNDC1_ENST00000340366.6_Silent_p.T543T	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	606						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CCCTGGCCACGCAGCCCCGCC	0.701000													15	16					0	0	1	0	0
DLG4	1742	broad.mit.edu	37	17	7096281	7096281	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr17:7096281G>A	ENST00000399510.2	-	19	2830	c.1978C>T	c.(1978-1980)Cga>Tga	p.R660*	DLG4_ENST00000399506.2_Nonsense_Mutation_p.R617*|DLG4_ENST00000302955.6_Nonsense_Mutation_p.R614*	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	617	Guanylate kinase-like.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						GCCACCTCTCGCACGGACTGG	0.612000													10	10					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86900300	86900300	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr1:86900300T>G	ENST00000370565.4	+	6	1006	c.844T>G	c.(844-846)Tct>Gct	p.S282A		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	282					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		AATCACAGACTCTGCTGACTT	0.483000													6	70					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3673674	3673674	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr20:3673674G>A	ENST00000344754.4	-	14	3612	c.3613C>T	c.(3613-3615)Ctc>Ttc	p.L1205F	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.L1205F	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1205	Ig-like C2-type 12.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCGTGGCTGAGGGCCAGCTGG	0.706000													18	18					0	0	1	0	0
TUBB3	10381	broad.mit.edu	37	16	89999982	89999982	+	Silent	SNP	C	C	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr16:89999982C>T	ENST00000304984.5	+	2	2352	c.57C>T	c.(55-57)atC>atT	p.I19I	TUBB3_ENST00000556922.1_Silent_p.I438I|TUBB3_ENST00000554336.1_Silent_p.I91I|TUBB3_ENST00000315491.7_Silent_p.I91I|TUBB3_ENST00000555576.1_Silent_p.I91I|TUBB3_ENST00000553967.1_Silent_p.I91I|TUBB3_ENST00000554444.1_Silent_p.I19I			Q13509	TBB3_HUMAN	tubulin, beta 3 class III	91					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		ACAATTTCATCTTTGGTAAGT	0.572000													33	17					0	0	1	0	0
POMT1	10585	broad.mit.edu	37	9	134379661	134379661	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr9:134379661T>A	ENST00000423007.1	+	2	498	c.56T>A	c.(55-57)cTt>cAt	p.L19H	POMT1_ENST00000341012.7_Intron|POMT1_ENST00000354713.4_Missense_Mutation_p.L19H|POMT1_ENST00000402686.3_Missense_Mutation_p.L19H|POMT1_ENST00000372228.3_Missense_Mutation_p.L19H|POMT1_ENST00000404875.2_Intron|POMT1_ENST00000541219.1_Intron|POMT1_ENST00000419118.2_Intron	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	19					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		AACTTGAGCCTTGTGGCCCTG	0.557000											OREG0019563	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	117					0	0	1	0	0
C15orf40	123207	broad.mit.edu	37	15	83677356	83677356	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr15:83677356A>G	ENST00000304177.5	-	3	343	c.229T>C	c.(229-231)Tgt>Cgt	p.C77R	C15orf40_ENST00000451195.3_Missense_Mutation_p.C104R|C15orf40_ENST00000513601.2_Missense_Mutation_p.C104R|C15orf40_ENST00000538348.2_Missense_Mutation_p.C104R|C15orf40_ENST00000565712.1_Intron|RP11-382A20.5_ENST00000566841.1_RNA	NM_001160114.1|NM_144597.2	NP_001153586.1|NP_653198.2	Q8WUR7	CO040_HUMAN	chromosome 15 open reading frame 40	77										large_intestine(3)|lung(2)|skin(1)	6						AGATACCGACAGAGCTCAGCA	0.428000													6	56					0	0	1	0	0
FHL5	9457	broad.mit.edu	37	6	97058500	97058500	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr6:97058500G>T	ENST00000326771.2	+	6	937	c.557G>T	c.(556-558)tGt>tTt	p.C186F	FHL5_ENST00000541107.1_Missense_Mutation_p.C186F	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5	186	LIM zinc-binding 3.					nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		CATAAAGAGTGTTTTCTGTGT	0.443000													53	82					3.40343e-31	4.06931e-31	1	1	0
GLDC	2731	broad.mit.edu	37	9	6536172	6536172	+	Silent	SNP	C	C	T	rs144937031	byFrequency	TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr9:6536172C>T	ENST00000321612.6	-	23	2880	c.2730G>A	c.(2728-2730)tcG>tcA	p.S910S		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	910					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CCTTGTCCTCCGACTCAGTGG	0.572000													4	22					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41135318	41135318	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr19:41135318G>T	ENST00000308370.7	+	34	4735	c.4735G>T	c.(4735-4737)Gag>Tag	p.E1579*	LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000396819.3_Nonsense_Mutation_p.E1512*|LTBP4_ENST00000204005.9_Nonsense_Mutation_p.E1542*|LTBP4_ENST00000545697.1_3'UTR|LTBP4_ENST00000243562.9_3'UTR	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1580	EGF-like 16.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CGAGTGTGATGAGGCCGAGGC	0.637000													13	47					1.5739e-10	1.80342e-10	1	1	0
HOXD9	3235	broad.mit.edu	37	2	176987556	176987556	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr2:176987556C>A	ENST00000249499.6	+	1	469	c.60C>A	c.(58-60)taC>taA	p.Y20*	HOXD-AS2_ENST00000440016.2_RNA	NM_014213.3	NP_055028.3	P28356	HXD9_HUMAN	homeobox D9	20						nucleus	sequence-specific DNA binding			endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		TCAGCAACTACTACGTGGACT	0.692000													6	13					3.59834e-05	3.80593e-05	1	1	0
LILRA4	23547	broad.mit.edu	37	19	54849922	54849922	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr19:54849922C>T	ENST00000291759.4	-	3	156	c.100G>A	c.(100-102)Gag>Aag	p.E34K		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	34	Ig-like C2-type 1.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GGACCTGGCTCGGCCCACAGG	0.572000											OREG0003656	type=REGULATORY REGION|Gene=LILRA4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	15	35					0	0	1	0	0
ATIC	471	broad.mit.edu	37	2	216189998	216189998	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr2:216189998A>G	ENST00000435675.1	+	4	713	c.322A>G	c.(322-324)Aca>Gca	p.T108A	ATIC_ENST00000540518.1_Missense_Mutation_p.T50A|ATIC_ENST00000236959.9_Missense_Mutation_p.T109A			P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	109					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	large_intestine(2)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	8		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	CTTTGTAAAGACAGTGGCTTC	0.408000			T	ALK	ALCL								30	47					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32560136	32560136	+	Silent	SNP	A	A	G			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr14:32560136A>G	ENST00000345122.3	+	2	576	c.261A>G	c.(259-261)gaA>gaG	p.E87E	ARHGAP5_ENST00000539826.2_Silent_p.E87E|ARHGAP5_ENST00000556611.1_Silent_p.E87E|ARHGAP5_ENST00000432921.1_Silent_p.E87E|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000433497.1_Intron	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	87					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		ATGGAGTAGAATGCAAAATTC	0.388000													4	66					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14801770	14801770	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr9:14801770G>A	ENST00000380881.4	-	21	4392	c.3577C>T	c.(3577-3579)Cgc>Tgc	p.R1193C	FREM1_ENST00000380880.3_Missense_Mutation_p.R1192C|FREM1_ENST00000422223.2_Missense_Mutation_p.R1192C			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1192					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGGCCATGGCGTGGCTTTTGA	0.527000													30	41					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152652494	152652494	+	Silent	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr6:152652494G>A	ENST00000367255.5	-	78	13927	c.13326C>T	c.(13324-13326)ggC>ggT	p.G4442G	SYNE1_ENST00000341594.5_Silent_p.G4307G|SYNE1_ENST00000265368.4_Silent_p.G4442G|SYNE1_ENST00000448038.1_Silent_p.G4371G|SYNE1_ENST00000423061.1_Silent_p.G4371G	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4442					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCTTCGCTGGCCCACTAAGT	0.493000										HNSCC(10;0.0054)			23	43					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3205573	3205573	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr8:3205573C>T	ENST00000602557.1	-	23	3973	c.3418G>A	c.(3418-3420)Ggc>Agc	p.G1140S	CSMD1_ENST00000542608.1_Missense_Mutation_p.G1139S|CSMD1_ENST00000400186.3_Missense_Mutation_p.G1140S|CSMD1_ENST00000537824.1_Missense_Mutation_p.G1139S|CSMD1_ENST00000539096.1_Missense_Mutation_p.G1139S|CSMD1_ENST00000520002.1_Missense_Mutation_p.G1140S|CSMD1_ENST00000602723.1_Missense_Mutation_p.G1140S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1140	CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATGCCCTTGCCGGCTTCTGTT	0.378000													11	12					0	0	1	0	0
ZNF395	55893	broad.mit.edu	37	8	28218558	28218558	+	Silent	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr8:28218558G>A	ENST00000344423.5	-	2	215	c.84C>T	c.(82-84)ccC>ccT	p.P28P	ZNF395_ENST00000523202.1_Silent_p.P28P|ZNF395_ENST00000523095.1_Silent_p.P28P	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	28					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GGGCAGCCGAGGGCCCCTCCG	0.682000													3	35					0	0	1	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276861	71276861	+	Silent	SNP	T	T	C	rs36179995		TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr11:71276861T>C	ENST00000398531.1	+	1	253	c.228T>C	c.(226-228)tcT>tcC	p.S76S	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	76	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						ACTGTGGCTCTTGTGGGGGCT	0.677000													5	178					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544783	23544783	+	Missense_Mutation	SNP	C	C	T	rs410211		TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr19:23544783C>T	ENST00000300619.7	-	4	1203	c.998G>A	c.(997-999)cGt>cAt	p.R333H	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.R301H	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	333				R -> H (in Ref. 1; AAA59469).		nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R333H(1)					all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAACGGCTAAAAGC	0.393000													4	117					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126730864	126730864	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr3:126730864A>C	ENST00000251772.4	+	9	2176	c.2107A>C	c.(2107-2109)Acc>Ccc	p.T703P	PLXNA1_ENST00000393409.2_Missense_Mutation_p.T726P			Q9UIW2	PLXA1_HUMAN	plexin A1	726					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity	p.T703P(2)		breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		AAAACCCATCACCCTGGCCGC	0.652000													7	44					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158608028	158608028	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr1:158608028C>A	ENST00000368148.3	-	36	5164	c.4984G>T	c.(4984-4986)Gca>Tca	p.A1662S	SPTA1_ENST00000368147.3_Missense_Mutation_p.A1662S	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1662					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCCTTGAGTGCATCCTAGAAA	0.428000													18	38					2.35188e-11	2.7522e-11	1	1	0
TRPM1	4308	broad.mit.edu	37	15	31355425	31355425	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr15:31355425C>A	ENST00000542188.1	-	7	1225	c.912G>T	c.(910-912)ttG>ttT	p.L304F	TRPM1_ENST00000397795.2_Missense_Mutation_p.L265F|TRPM1_ENST00000256552.6_Missense_Mutation_p.L287F	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	265					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GCAGGTATTCCAAGACGATGG	0.587000													3	31					0.00909568	0.00926412	1	1	0
PPP2CB	5516	broad.mit.edu	37	8	30655146	30655146	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr8:30655146A>C	ENST00000221138.4	-	3	887	c.437T>G	c.(436-438)tTt>tGt	p.F146C	PPP2CB_ENST00000518564.1_Intron	NM_001009552.1	NP_001009552.1	P62714	PP2AB_HUMAN	protein phosphatase 2, catalytic subunit, beta isozyme	146					protein dephosphorylation	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex|spindle pole	metal ion binding			breast(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	9				KIRC - Kidney renal clear cell carcinoma(542;0.095)|Kidney(114;0.114)	Vitamin E(DB00163)	GAGATCTGTAAAATATTTCCA	0.378000													7	61					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49958074	49958074	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chrX:49958074C>A	ENST00000376056.2	-	5	1413	c.1263G>T	c.(1261-1263)ttG>ttT	p.L421F	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376058.2_Intron|AKAP4_ENST00000376064.3_Missense_Mutation_p.L421F|AKAP4_ENST00000358526.2_Missense_Mutation_p.L430F			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	430					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					GGGCACTGACCAAGCGCTTCA	0.458000													53	9					9.86064e-34	1.20519e-33	1	1	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													3	34					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22414907	22414907	+	Silent	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr4:22414907G>A	ENST00000334304.5	-	14	2399	c.2130C>T	c.(2128-2130)aaC>aaT	p.N710N	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	710	GPS.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				CTCCTTGTCCGTTCAGCAAAT	0.453000													4	85					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	41					0	0	1	0	0
VSTM4	196740	broad.mit.edu	37	10	50227748	50227748	+	Missense_Mutation	SNP	C	C	T	rs141399513	byFrequency	TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr10:50227748C>T	ENST00000332853.3	-	8	933	c.910G>A	c.(910-912)Gcc>Acc	p.A304T		NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4	304						integral to membrane|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						CTGGTGGGGGCGCCTTTGGCA	0.493000													22	23					0	0	1	0	0
CCDC28A	25901	broad.mit.edu	37	6	139095001	139095001	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr6:139095001C>T	ENST00000332797.6	+	1	345	c.190C>T	c.(190-192)Cgg>Tgg	p.R64W		NM_015439.2	NP_056254.1	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	64										autonomic_ganglia(1)|large_intestine(3)|lung(8)|ovary(1)	13				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		CGGGTCTTTGCGGGTTGCGGA	0.617000													4	126					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8132109	8132109	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr17:8132109A>C	ENST00000315684.8	-	21	3330	c.3323T>G	c.(3322-3324)cTa>cGa	p.L1108R		NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	1108					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						GACGAAATCTAGGAGGGAGGC	0.597000													4	10					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14884750	14884750	+	Splice_Site	SNP	C	C	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr19:14884750C>T	ENST00000315576.3	-	4	650	c.199_splice	c.e4+1	p.D67_splice	EMR2_ENST00000392965.3_Splice_Site_p.D67_splice|EMR2_ENST00000601345.1_Splice_Site_p.D67_splice|EMR2_ENST00000594076.1_Splice_Site_p.D67_splice|EMR2_ENST00000392967.2_Splice_Site_p.D67_splice|EMR2_ENST00000353876.1_Splice_Site_p.D67_splice|EMR2_ENST00000346057.1_Splice_Site_p.D67_splice|EMR2_ENST00000594294.1_Splice_Site_p.D67_splice|EMR2_ENST00000353005.1_Splice_Site_p.D67_splice|EMR2_ENST00000599423.1_5'UTR|EMR2_ENST00000595839.1_Splice_Site_p.D67_splice|EMR2_ENST00000596991.2_Splice_Site_p.D67_splice	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	67	EGF-like 2; calcium-binding.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.D67N(1)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						GCCTCTGTACCGTCACAAGTC	0.582000													4	121					0	0	1	0	0
DHCR24	1718	broad.mit.edu	37	1	55337177	55337177	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr1:55337177C>T	ENST00000371269.3	-	5	820	c.722G>A	c.(721-723)cGt>cAt	p.R241H	DHCR24_ENST00000535035.1_Missense_Mutation_p.R200H|DHCR24_ENST00000537443.1_Missense_Mutation_p.R73H	NM_014762.3	NP_055577.1	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase	241					anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			large_intestine(2)|liver(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7						TGGCTCGAAACGCAGCTTGAC	0.607000													16	7					0	0	1	0	0
LARP4	113251	broad.mit.edu	37	12	50869343	50869343	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr12:50869343A>C	ENST00000398473.2	+	16	1983	c.1871A>C	c.(1870-1872)cAg>cCg	p.Q624P	LARP4_ENST00000429001.3_Missense_Mutation_p.Q630P|LARP4_ENST00000518444.1_Missense_Mutation_p.Q623P|LARP4_ENST00000347328.5_Missense_Mutation_p.Q553P|LARP4_ENST00000293618.8_Missense_Mutation_p.Q553P	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	624							nucleotide binding|RNA binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						GAAGTGTGCCAGAAGCCCCCT	0.398000													13	259					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42584019	42584019	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr19:42584019C>T	ENST00000600245.1	+	2	1916	c.1261C>T	c.(1261-1263)Ccc>Tcc	p.P421S	ZNF574_ENST00000359044.4_Missense_Mutation_p.P421S|ZNF574_ENST00000222339.7_Missense_Mutation_p.P511S|CTB-59C6.3_ENST00000594531.1_RNA			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	421	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				TGTCCCTCTGCCCACAACACC	0.577000													23	36					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94732161	94732161	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr14:94732161G>A	ENST00000304338.3	+	22	2469	c.2315G>A	c.(2314-2316)cGa>cAa	p.R772Q		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	772						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						AAACTGATTCGAAGCCAGTCT	0.363000													39	65					0	0	1	0	0
IL8	0	broad.mit.edu	37	4	74606394	74606394	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr4:74606394G>T	ENST00000307407.3	+	1	172	c.19G>T	c.(19-21)Gtg>Ttg	p.V7L	IL8_ENST00000401931.1_Missense_Mutation_p.V7L	NM_000584.3	NP_000575.1	P10145	IL8_HUMAN	interleukin 8	7					angiogenesis|calcium-mediated signaling|cell cycle arrest|cellular response to lipopolysaccharide|embryonic digestive tract development|G-protein coupled receptor protein signaling pathway|immune response|induction of positive chemotaxis|inflammatory response|negative regulation of cell proliferation|neutrophil activation|neutrophil chemotaxis|positive regulation of neutrophil chemotaxis|regulation of cell adhesion|regulation of retroviral genome replication	extracellular space|intracellular	chemokine activity|interleukin-8 receptor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(2)|urinary_tract(1)	6	Breast(15;0.00102)		all cancers(17;0.00169)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)	LUSC - Lung squamous cell carcinoma(721;0.008)	Ketoprofen(DB01009)|Salbutamol(DB01001)|Simvastatin(DB00641)|Zileuton(DB00744)	CAAGCTGGCCGTGGCTCTCTT	0.488000													8	117					1.58986e-06	1.71456e-06	1	1	0
AKAP1	8165	broad.mit.edu	37	17	55183580	55183580	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr17:55183580A>C	ENST00000337714.3	+	2	988	c.755A>C	c.(754-756)cAg>cCg	p.Q252P	AKAP1_ENST00000571629.1_Missense_Mutation_p.Q252P|AKAP1_ENST00000572557.1_Missense_Mutation_p.Q252P|AKAP1_ENST00000539273.1_Missense_Mutation_p.Q252P|AKAP1_ENST00000314126.3_Missense_Mutation_p.Q252P	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	252					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					AGCTCATCCCAGGTGGTGGGG	0.567000													22	38					0	0	1	0	0
HEY2	23493	broad.mit.edu	37	6	126080681	126080681	+	Silent	SNP	C	C	T			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr6:126080681C>T	ENST00000368364.3	+	5	944	c.747C>T	c.(745-747)tgC>tgT	p.C249C	HEY2_ENST00000368365.1_Silent_p.C203C	NM_012259.2	NP_036391.1	Q9UBP5	HEY2_HUMAN	hes-related family bHLH transcription factor with YRPW motif 2	249					negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)|large_intestine(7)|lung(5)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		TCGCCCCCTGCGTGCCACCTC	0.672000													37	157					0	0	1	0	0
HPCA	3208	broad.mit.edu	37	1	33359401	33359401	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr1:33359401delA	ENST00000373467.3	+	4	622	c.520delA	c.(520-522)aafs	p.K174fs		NM_002143.2	NP_002134.2	P84074	HPCA_HUMAN	hippocalcin	174	EF-hand 4.						actin binding|calcium ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CCGCGGGGCCAAAAGCGACCC	0.692													2	4	---	---	---	---					
NGEF	25791	broad.mit.edu	37	2	233792687	233792687	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZG-A9LZ-01A-11D-A41K-08	TCGA-ZG-A9LZ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	678b42ec-7932-47a8-98df-39f5d25b7562	4194550d-f14a-484d-85d6-a2a15cd7a2ad	g.chr2:233792687delA	ENST00000373552.4	-	1	177	c.23delT	c.(22-24)tcfs	p.F8fs	NGEF_ENST00000409079.1_Frame_Shift_Del_p.F8fs|NGEF_ENST00000264051.3_Intron	NM_001114090.1	NP_001107562.1	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	0	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GGCGGCGCTGAAGGCAGCGGC	0.781													2	4	---	---	---	---					
