Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTPN23	25930	broad.mit.edu	37	3	47454084	47454084	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr3:47454084C>G	ENST00000265562.4	+	24	4475	c.4398C>G	c.(4396-4398)tgC>tgG	p.C1466W	PTPN23_ENST00000431726.1_Missense_Mutation_p.C1340W	NM_015466.2	NP_056281.1	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type 23	1466					cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|large_intestine(5)|lung(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTCCTCCATGCAAACCCTTGG	0.602000													10	29					0	0	1	0	0
AGPAT9	84803	broad.mit.edu	37	4	84519225	84519225	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr4:84519225G>T	ENST00000395226.2	+	11	1236	c.1018G>T	c.(1018-1020)Gca>Tca	p.A340S	AGPAT9_ENST00000264409.4_Missense_Mutation_p.A340S	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	340					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				GTTCGGTGATGCATTTTGGAA	0.448000													17	69					1.56452e-12	1.76425e-12	1	1	0
GLUD1P2	0	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													3	11					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128494226	128494226	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr7:128494226G>A	ENST00000325888.8	+	40	6944	c.6683G>A	c.(6682-6684)cGg>cAg	p.R2228Q	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Missense_Mutation_p.R2195Q	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2228	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TTCCTGGGCCGGGAGCGCCTG	0.716000													7	21					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138601154	138601154	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr6:138601154G>A	ENST00000251691.4	+	14	2480	c.2314G>A	c.(2314-2316)Gtg>Atg	p.V772M		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	772	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CATGAAGCAGGTGCAGACCAG	0.542000													3	37					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157454311	157454311	+	Missense_Mutation	SNP	G	G	A	rs150249745		TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr6:157454311G>A	ENST00000346085.5	+	8	2522	c.2521G>A	c.(2521-2523)Ggt>Agt	p.G841S	ARID1B_ENST00000275248.4_Missense_Mutation_p.G770S|ARID1B_ENST00000367148.1_Missense_Mutation_p.G828S|ARID1B_ENST00000350026.5_Missense_Mutation_p.G828S	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	828					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TGGGACTTACGGTCCACAGAT	0.473000													15	15					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51224910	51224910	+	Silent	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr14:51224910C>T	ENST00000245441.5	-	18	3028	c.2838G>A	c.(2836-2838)agG>agA	p.R946R	NIN_ENST00000389868.3_Intron|NIN_ENST00000324330.9_Silent_p.R946R|NIN_ENST00000382043.4_Intron|NIN_ENST00000382041.3_Silent_p.R946R|NIN_ENST00000530997.2_Silent_p.R946R|NIN_ENST00000453196.1_Silent_p.R946R	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	946					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					CCCTCAGTTCCCTTTTGTGAC	0.537000			T	PDGFRB	MPD								46	63					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90494821	90494821	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr6:90494821C>G	ENST00000369393.3	-	9	1474	c.1359G>C	c.(1357-1359)tgG>tgC	p.W453C	MDN1_ENST00000428876.1_Missense_Mutation_p.W453C			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	453					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GCGGTCGATACCAATTTCCTC	0.383000													37	93					0	0	1	0	0
ANKRD53	79998	broad.mit.edu	37	2	71206323	71206323	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr2:71206323C>G	ENST00000272421.6	+	2	533	c.267C>G	c.(265-267)gaC>gaG	p.D89E	ANKRD53_ENST00000360589.3_Missense_Mutation_p.D89E|ANKRD53_ENST00000441349.1_Intron|ANKRD53_ENST00000457410.1_Intron|AC007040.11_ENST00000606025.1_Intron	NM_024933.3	NP_079209.3	Q8N9V6	ANR53_HUMAN	ankyrin repeat domain 53	89										endometrium(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	11						CCCGCGCTGACCCCAGCCCCA	0.716000													23	54					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30359240	30359240	+	Missense_Mutation	SNP	G	G	C	rs138791308		TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr21:30359240G>C	ENST00000361371.4	-	2	208	c.58C>G	c.(58-60)Cga>Gga	p.R20G	LTN1_ENST00000389195.2_Missense_Mutation_p.R66G|LTN1_ENST00000389194.2_Missense_Mutation_p.R66G	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	20							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						TCTGCAGCTCGGCCACTGTTT	0.433000													20	23					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42815085	42815085	+	Silent	SNP	T	T	C			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr20:42815085T>C	ENST00000372980.3	-	1	1133	c.261A>G	c.(259-261)acA>acG	p.T87T	JPH2_ENST00000342272.3_Silent_p.T87T	NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	87	Gly-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TGAAGCCATGTGTCCACTCGC	0.612000													16	34					0	0	1	0	0
CDC45	8318	broad.mit.edu	37	22	19502368	19502368	+	Silent	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr22:19502368C>T	ENST00000407835.1	+	15	1570	c.1314C>T	c.(1312-1314)ctC>ctT	p.L438L	CDC45_ENST00000437685.2_Silent_p.L470L|CDC45_ENST00000263201.1_Silent_p.L438L|CDC45_ENST00000404724.3_Silent_p.L392L			O75419	CDC45_HUMAN	cell division cycle 45	438					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	19						GCACCAACCTCGTCATCTCCC	0.597000													13	46					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													3	64					0	0	1	0	0
PA2G4	5036	broad.mit.edu	37	12	56503666	56503666	+	Silent	SNP	G	G	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr12:56503666G>A	ENST00000303305.6	+	7	995	c.576G>A	c.(574-576)caG>caA	p.Q192Q	RP11-603J24.17_ENST00000548595.1_RNA|PA2G4_ENST00000552766.1_Silent_p.Q192Q	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	192					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			AGTTGAAGCAGCATGTCATCG	0.443000													3	55					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577046	7577046	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr17:7577046C>A	ENST00000420246.2	-	8	1024	c.892G>T	c.(892-894)Gag>Tag	p.E298*	TP53_ENST00000269305.4_Nonsense_Mutation_p.E298*|TP53_ENST00000359597.4_Nonsense_Mutation_p.E298*|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Nonsense_Mutation_p.E298*|TP53_ENST00000455263.2_Nonsense_Mutation_p.E298*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	298	Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E298*(49)|p.0?(8)|p.?(2)|p.E298K(1)|p.L299fs*2(1)|p.L265_K305del41(1)|p.E298fs*53(1)|p.G293fs*1(1)|p.E298Q(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGGCAGCTCGTGGTGAGGC	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	39					6.31663e-08	6.83227e-08	1	1	0
RALBP1	10928	broad.mit.edu	37	18	9524699	9524699	+	Silent	SNP	G	G	A	rs150447479		TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr18:9524699G>A	ENST00000019317.4	+	5	1384	c.1161G>A	c.(1159-1161)acG>acA	p.T387T	RALBP1_ENST00000383432.3_Silent_p.T387T			Q15311	RBP1_HUMAN	ralA binding protein 1	387					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(3)|upper_aerodigestive_tract(1)	14						ACATGGCCACGATGCCCACGC	0.532000													5	32					0	0	1	0	0
RNF144A	9781	broad.mit.edu	37	2	7137191	7137191	+	Splice_Site	SNP	T	T	G			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr2:7137191T>G	ENST00000320892.6	+	3	576	c.135_splice	c.e3+1	p.L45_splice	RNF144A_ENST00000467276.1_Intron	NM_014746.3	NP_055561.2	P50876	R144A_HUMAN	ring finger protein 144A	45						Golgi apparatus|integral to membrane	ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)	25	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;0.226)		OV - Ovarian serous cystadenocarcinoma(76;0.195)		TTCTGTACTCTGGTTGGTCTT	0.458000													14	51					0	0	1	0	0
PAEP	5047	broad.mit.edu	37	9	138454224	138454224	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr9:138454224A>C	ENST00000479141.1	+	2	225	c.181A>C	c.(181-183)Atc>Ctc	p.I61L	PAEP_ENST00000277508.5_Missense_Mutation_p.I61L|PAEP_ENST00000371766.2_Missense_Mutation_p.I61L	NM_002571.2	NP_002562.2	P09466	PAEP_HUMAN	progestagen-associated endometrial protein	61					multicellular organismal development	extracellular region	binding|transporter activity			cervix(1)|endometrium(1)|lung(1)|prostate(1)|skin(1)|stomach(1)	6				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		GAGGGTCCACATCACCTCACT	0.617000													13	32					0	0	1	0	0
ZBTB9	221504	broad.mit.edu	37	6	33423655	33423655	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr6:33423655C>T	ENST00000395064.2	+	2	1046	c.778C>T	c.(778-780)Cga>Tga	p.R260*		NM_152735.3	NP_689948.1	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	260	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(1)|upper_aerodigestive_tract(2)	11						TGCTACTCCCCGAAAGCTTCC	0.577000													9	43					0	0	1	0	0
FAM86A	196483	broad.mit.edu	37	16	5135731	5135731	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr16:5135731G>A	ENST00000427587.4	-	8	963	c.895C>T	c.(895-897)Cgg>Tgg	p.R299W	ALG1_ENST00000592661.1_Intron|FAM86A_ENST00000458008.4_Missense_Mutation_p.R265W|FAM86A_ENST00000587133.1_Missense_Mutation_p.R238W	NM_201400.2	NP_958802.1	Q96G04	FA86A_HUMAN	family with sequence similarity 86, member A	299										endometrium(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	12						ATCCCGGCCCGGCCTGGAAAC	0.567000													11	88					0	0	1	0	0
TFDP1	7027	broad.mit.edu	37	13	114288328	114288328	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr13:114288328C>T	ENST00000375370.5	+	7	810	c.598C>T	c.(598-600)Cag>Tag	p.Q200*	TFDP1_ENST00000544902.1_Nonsense_Mutation_p.Q105*|TFDP1_ENST00000538138.1_Nonsense_Mutation_p.Q105*	NM_007111.4	NP_009042.1	Q14186	TFDP1_HUMAN	transcription factor Dp-1	200					cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			CAACTCGGCTCAGGAATGTCA	0.502000										TSP Lung(29;0.18)			31	41					0	0	1	0	0
FBXL6	26233	broad.mit.edu	37	8	145579637	145579637	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr8:145579637C>A	ENST00000331890.5	-	8	1527	c.1463G>T	c.(1462-1464)aGc>aTc	p.S488I	FBXL6_ENST00000455319.2_Missense_Mutation_p.S482I|FBXL6_ENST00000526524.1_Intron	NM_012162.2	NP_036294.1	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6	488					proteolysis		ubiquitin-protein ligase activity			endometrium(1)|lung(3)|ovary(1)	5	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CCTGACAGTGCTTGGTGTGAC	0.637000													15	29					4.14922e-12	4.58143e-12	1	1	0
IGSF9	57549	broad.mit.edu	37	1	159912790	159912790	+	Silent	SNP	G	G	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr1:159912790G>A	ENST00000368094.1	-	3	407	c.210C>T	c.(208-210)ttC>ttT	p.F70F	IGSF9_ENST00000361509.3_Silent_p.F70F	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	70	Ig-like 1.					cell junction|integral to membrane|synapse		p.F70F(1)		central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			AGTAGAGGCCGAACTGGATGA	0.602000													5	53					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31671327	31671327	+	Silent	SNP	C	C	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr20:31671327C>A	ENST00000375483.3	+	3	324	c.324C>A	c.(322-324)atC>atA	p.I108I		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	108						cytoplasm|extracellular region	lipid binding										ATGGTGAGATCCTTGAGTCCG	0.532000													28	70					1.08312e-15	1.24794e-15	1	1	0
RPL3L	6123	broad.mit.edu	37	16	1996981	1996981	+	Silent	SNP	G	G	A	rs148725709		TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr16:1996981G>A	ENST00000268661.7	-	6	901	c.807C>T	c.(805-807)gcC>gcT	p.A269A		NM_005061.2	NP_005052.1	Q92901	RL3L_HUMAN	ribosomal protein L3-like	269					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	17						CCTTCTGCCCGGCCCGAGCAA	0.662000													28	78					0	0	1	0	0
RAB33A	9363	broad.mit.edu	37	X	129318354	129318354	+	Silent	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chrX:129318354C>T	ENST00000257017.4	+	2	768	c.354C>T	c.(352-354)gaC>gaT	p.D118D		NM_004794.2	NP_004785.1	Q14088	RB33A_HUMAN	RAB33A, member RAS oncogene family	118					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(5)	11						TCGTCTATGACGTCACCAAGA	0.517000													4	29					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44949994	44949994	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chrX:44949994C>T	ENST00000377967.4	+	26	3804	c.3763C>T	c.(3763-3765)Cgg>Tgg	p.R1255W	KDM6A_ENST00000543216.1_Missense_Mutation_p.R1176W|KDM6A_ENST00000536777.1_Missense_Mutation_p.R1210W|KDM6A_ENST00000382899.4_Missense_Mutation_p.R1262W	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	1255	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.R1255W(1)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						GGCAGTGGAACGGTACGAATG	0.388000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								3	38					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40395884	40395884	+	Nonsense_Mutation	SNP	G	G	A	rs146994069		TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr19:40395884G>A	ENST00000221347.6	-	15	7520	c.7513C>T	c.(7513-7515)Cga>Tga	p.R2505*		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2505	VWFD 6.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACACTGACTCGCCCATTACCC	0.627000													18	101					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141930	29141930	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr6:29141930G>A	ENST00000377167.2	+	1	620	c.518G>A	c.(517-519)cGc>cAc	p.R173H		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						TGTGGACATCGCCTAGTGGAT	0.468000													37	121					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	62993383	62993383	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr15:62993383G>A	ENST00000561311.1	+	16	1896	c.1666G>A	c.(1666-1668)Gga>Aga	p.G556R	TLN2_ENST00000306829.6_Missense_Mutation_p.G556R			Q9Y4G6	TLN2_HUMAN	talin 2	556					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						TATCACGGCCGGAACGGCTTC	0.438000													3	58					0	0	1	0	0
KCNK2	3776	broad.mit.edu	37	1	215408192	215408192	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr1:215408192G>A	ENST00000444842.2	+	7	1135	c.985G>A	c.(985-987)Gct>Act	p.A329T	KCNK2_ENST00000391894.2_Missense_Mutation_p.A314T|KCNK2_ENST00000391895.2_Missense_Mutation_p.A325T	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	329							outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CAGAGCACACGCTGCTGAGTG	0.458000													23	57					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855943	12855943	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr1:12855943G>T	ENST00000332296.7	+	4	1326	c.1223G>T	c.(1222-1224)aGc>aTc	p.S408I	PRAMEF1_ENST00000400814.3_Missense_Mutation_p.S163I	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	408										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGCAAGTTAAGCCTGGAGACG	0.542000													5	106					0.00198382	0.00206161	1	1	0
LZTS1	11178	broad.mit.edu	37	8	20110316	20110316	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr8:20110316C>T	ENST00000381569.1	-	3	1483	c.1126G>A	c.(1126-1128)Gcg>Acg	p.A376T	LZTS1_ENST00000522290.1_Missense_Mutation_p.A376T|LZTS1_ENST00000265801.6_Missense_Mutation_p.A376T			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	376					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TCCTCCAGCGCGGGGCCGAAG	0.662000													8	26					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50074463	50074463	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr5:50074463A>G	ENST00000281631.5	+	9	807	c.649A>G	c.(649-651)Aca>Gca	p.T217A	PARP8_ENST00000514342.2_5'UTR|PARP8_ENST00000505554.1_Missense_Mutation_p.T196A|PARP8_ENST00000503750.2_Missense_Mutation_p.T217A|PARP8_ENST00000514067.2_Missense_Mutation_p.T217A|PARP8_ENST00000505697.2_Missense_Mutation_p.T217A|PARP8_ENST00000511363.2_3'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	217						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				CTGTTCACTTACACAGTATTT	0.318000													38	65					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74329100	74329100	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr2:74329100C>T	ENST00000409262.3	+	9	4780	c.4780C>T	c.(4780-4782)Cgg>Tgg	p.R1594W		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1594							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GGAGGCTGCCCGGCTGGGCCT	0.662000													18	17					0	0	1	0	0
CDK7	1022	broad.mit.edu	37	5	68565120	68565120	+	Splice_Site	SNP	G	G	A	rs111845256		TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr5:68565120G>A	ENST00000502604.1	+	8	925	c.435_splice	c.e8+1	p.P145_splice	CDK7_ENST00000256443.3_Splice_Site_p.P238_splice|CDK7_ENST00000513629.1_3'UTR|CDK7_ENST00000514676.1_Splice_Site_p.P201_splice			P50613	CDK7_HUMAN	cyclin-dependent kinase 7	238	Protein kinase.				androgen receptor signaling pathway|cell division|cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex|mitochondrion	androgen receptor binding|ATP binding|cyclin-dependent protein kinase activity|DNA-dependent ATPase activity|protein C-terminus binding|RNA polymerase II carboxy-terminal domain kinase activity|transcription coactivator activity			endometrium(1)|lung(2)	3		Lung NSC(167;7.26e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.98e-56)|Epithelial(20;3.54e-52)|all cancers(19;9.11e-48)|Lung(70;0.0185)		AACAGTGGCCGGTAAGCCTTT	0.363000								Nucleotide excision repair (NER)					4	77					0	0	1	0	0
CLEC17A	388512	broad.mit.edu	37	19	14710850	14710850	+	Silent	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr19:14710850C>T	ENST00000547437.1	+	12	827	c.750C>T	c.(748-750)cgC>cgT	p.R250R	CLEC17A_ENST00000417570.1_Silent_p.R250R|CLEC17A_ENST00000397439.2_Silent_p.R233R	NM_207390.3	NP_997273.3	Q6ZS10	CL17A_HUMAN	C-type lectin domain family 17, member A	250						cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity										CAGACTGCCGCCGAATTACCT	0.552000													28	41					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V|FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													5	88					0	0	1	0	0
CTC-457E21.3	0	broad.mit.edu	37	19	22783087	22783087	+	RNA	SNP	A	A	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr19:22783087A>T	ENST00000600260.1	+	0	594					NR_033899.1																						CTCCAAGCCCAGGTACAGGAC	0.642000													5	12					0	0	1	0	0
ZC2HC1A	51101	broad.mit.edu	37	8	79598725	79598725	+	Silent	SNP	T	T	C			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr8:79598725T>C	ENST00000263849.4	+	4	336	c.234T>C	c.(232-234)tcT>tcC	p.S78S	ZC2HC1A_ENST00000521176.1_3'UTR	NM_016010.2	NP_057094.2	Q96GY0	F164A_HUMAN	zinc finger, C2HC-type containing 1A	78																	AGAAACCATCTAATTGGAGAA	0.338000													4	7					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93125791	93125791	+	Missense_Mutation	SNP	A	A	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr14:93125791A>T	ENST00000216487.7	+	7	2471	c.2312A>T	c.(2311-2313)gAc>gTc	p.D771V	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	771	VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				CTCATCTACGACTCCATGGCC	0.567000													9	49					0	0	1	0	0
IGHV4OR15-8	0	broad.mit.edu	37	15	22473333	22473333	+	RNA	SNP	A	A	G			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr15:22473333A>G	ENST00000557788.2	-	0	20																											CCAGGAGGAGAAAGAACCACA	0.512000													3	56					0	0	1	0	0
ITFG1	81533	broad.mit.edu	37	16	47196504	47196504	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr16:47196504C>T	ENST00000320640.6	-	15	1753	c.1525G>A	c.(1525-1527)Gca>Aca	p.A509T	ITFG1_ENST00000568047.1_5'UTR|ITFG1_ENST00000544001.2_Missense_Mutation_p.A396T|RP11-329J18.2_ENST00000564705.1_RNA|RP11-329J18.2_ENST00000565694.1_RNA	NM_030790.3	NP_110417.2	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	509						extracellular region|integral to membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	19		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				AGAAAATTTGCGCTCCGACCT	0.358000													3	62					0	0	1	0	0
NDN	4692	broad.mit.edu	37	15	23932059	23932059	+	Silent	SNP	C	C	T			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr15:23932059C>T	ENST00000331837.4	-	1	391	c.306G>A	c.(304-306)gcG>gcA	p.A102A		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	102	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		TGAGCTCGTGCGCCTTCTGCA	0.657000									Prader-Willi syndrome				19	96					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	449902	449902	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr9:449902G>A	ENST00000432829.2	+	45	6048	c.5732G>A	c.(5731-5733)gGc>gAc	p.G1911D	DOCK8_ENST00000382329.1_Missense_Mutation_p.G1446D|DOCK8_ENST00000469391.1_Missense_Mutation_p.G1879D|DOCK8_ENST00000453981.1_Missense_Mutation_p.G1979D	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1979					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GTGCTGCAAGGCTCTGTGGGA	0.473000													36	25					0	0	1	0	0
JUND	3727	broad.mit.edu	37	19	18391896	18391896	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr19:18391896C>A	ENST00000252818.3	-	1	536	c.399G>T	c.(397-399)gaG>gaT	p.E133D		NM_005354.4	NP_005345.3	P17535	JUND_HUMAN	jun D proto-oncogene	133					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(2)|prostate(1)	3						CGAACTCCTGCTCCTCGCTGG	0.706000													4	11					0.184627	0.184627	1	1	0
CCDC88A	55704	broad.mit.edu	37	2	55523004	55523004	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr2:55523004T>G	ENST00000436346.1	-	31	6121	c.5280A>C	c.(5278-5280)aaA>aaC	p.K1760N	CCDC88A_ENST00000263630.8_Missense_Mutation_p.K1732N|CCDC88A_ENST00000413716.2_Intron|CCDC88A_ENST00000422883.2_Missense_Mutation_p.K261N|CCDC88A_ENST00000336838.6_Missense_Mutation_p.K1759N	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	1760					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						TATCTTCAGTTTTTCGAGGAC	0.428000													26	66					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167328878	167328878	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr2:167328878G>A	ENST00000409855.1	-	5	647	c.521C>T	c.(520-522)tCc>tTc	p.S174F		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	174					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						ACCGAGGAAGGAAAATGATCC	0.348000													8	5					0	0	1	0	0
SRSF4	6429	broad.mit.edu	37	1	29475219	29475221	+	In_Frame_Del	DEL	CTT	CTT	-	rs138237342	by1000genomes	TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr1:29475219_29475221delCTT	ENST00000373795.4	-	6	1420_1422	c.1186_1188delAAG	c.(1186-1188)del	p.K396del	SRSF4_ENST00000546138.1_3'UTR|SRSF4_ENST00000466448.1_5'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	396	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						CAGTGTCTTCCTTCTTCTTCTTC	0.601													7	174	---	---	---	---					
CCT4	10575	broad.mit.edu	37	2	62099679	62099681	+	In_Frame_Del	DEL	AAC	AAC	-			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr2:62099679_62099681delAAC	ENST00000394440.3	-	11	1464_1466	c.1168_1170delGTT	c.(1168-1170)del	p.V390del	AC107081.5_ENST00000425779.1_RNA|CCT4_ENST00000544079.1_In_Frame_Del_p.V360del|CCT4_ENST00000538252.1_In_Frame_Del_p.V334del|CCT4_ENST00000544185.1_In_Frame_Del_p.V240del|CCT4_ENST00000461540.2_Intron	NM_006430.3	NP_006421.2	P50991	TCPD_HUMAN	chaperonin containing TCP1, subunit 4 (delta)	390					'de novo' posttranslational protein folding	melanosome|microtubule organizing center|nucleus	ATP binding|unfolded protein binding			breast(1)|large_intestine(2)|lung(6)|ovary(2)	11	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;6.5e-06)|Epithelial(17;0.0647)|all cancers(80;0.221)			TAGAACCACGAACAACAATTGTA	0.404													9	94	---	---	---	---					
LA16c-306E5.3	0	broad.mit.edu	37	16	3546140	3546141	+	RNA	INS	-	-	A	rs74546027		TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr16:3546140_3546141insA	ENST00000574423.2	+	0	111																											gactccgtctcaaaaaaaaaaa	0.559													2	4	---	---	---	---					
PPL	5493	broad.mit.edu	37	16	4960866	4960867	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr16:4960866_4960867delCT	ENST00000345988.2	-	2	235_236	c.146_147delAG	c.(145-147)gfs	p.E49fs	PPL_ENST00000590782.2_Frame_Shift_Del_p.E49fs	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	49					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GCATCTTGGCCTCTGTGTCCAC	0.589													13	95	---	---	---	---					
CHD9	80205	broad.mit.edu	37	16	53269119	53269119	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr16:53269119delG	ENST00000566029.1	+	11	2743	c.2534delG	c.(2533-2535)tgfs	p.W845fs	CHD9_ENST00000447540.1_Frame_Shift_Del_p.W845fs|CHD9_ENST00000564845.1_Frame_Shift_Del_p.W845fs|CHD9_ENST00000398510.3_Frame_Shift_Del_p.W845fs			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	845					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				TCTAATATTTGGAAGAAAATA	0.358													2	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578495	7578501	+	Frame_Shift_Del	DEL	CAGCTGC	CAGCTGC	-			TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr17:7578495_7578501delCAGCTGC	ENST00000420246.2	-	5	561_567	c.429_435delGCAGCTG	c.(427-435)gtfs	p.VQL143fs	TP53_ENST00000455263.2_Frame_Shift_Del_p.VQL143fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.VQL143fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.VQL143fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.VQL143fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.VQL143fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	143	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> A (in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q144*(36)|p.L145P(17)|p.L145Q(17)|p.Q144L(8)|p.0?(8)|p.L145L(8)|p.L145R(7)|p.Q144H(4)|p.Q144R(4)|p.Q144P(4)|p.Q144fs*25(3)|p.Q144fs*26(3)|p.Q144K(2)|p.Q144del(2)|p.Q12*(2)|p.Q144Q(2)|p.Q51*(2)|p.V143V(2)|p.L145V(2)|p.L137_W146del10(1)|p.P142_Q144delPVQ(1)|p.L145del(1)|p.W146fs*25(1)|p.A138_V143delAKTCPV(1)|p.W146fs*22(1)|p.W146fs*23(1)|p.Q51fs*25(1)|p.V143_S149del(1)|p.Q144_G154del11(1)|p.Q144fs*32(1)|p.Q144fs*16(1)|p.Q144fs*4(1)|p.L145M(1)|p.Q12fs*25(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AATCAACCCACAGCTGCACAGGGCAGG	0.599		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	37	---	---	---	---					
RSPH6A	81492	broad.mit.edu	37	19	46299165	46299167	+	In_Frame_Del	DEL	CCT	CCT	-	rs62639328	byFrequency	TCGA-ZG-A9M4-01A-11D-A41K-08	TCGA-ZG-A9M4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c32797e-d804-4cab-a0c1-2aebeed8f037	231d6294-d947-400e-a0c1-15694c4839c9	g.chr19:46299165_46299167delCCT	ENST00000221538.3	-	6	2256_2258	c.2114_2116delAGG	c.(2113-2118)ggc>g	p.EG705del	RSPH6A_ENST00000597055.1_3'UTR|RSPH6A_ENST00000600188.1_In_Frame_Del_p.EG441del	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	705	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						tcctcctcgccctcctcctcctc	0.586													7	81	---	---	---	---					
