Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GSAP	54103	broad.mit.edu	37	7	76982299	76982299	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr7:76982299T>G	ENST00000257626.7	-	18	1531	c.1453A>C	c.(1453-1455)Aaa>Caa	p.K485Q		NM_017439.3	NP_059135.2			gamma-secretase activating protein																		GGCAATAGTTTGTCCATGTTA	0.363000													6	271					0	0	1	0	0
HYOU1	10525	broad.mit.edu	37	11	118919563	118919563	+	Silent	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:118919563G>A	ENST00000404233.3	-	18	2152	c.2028C>T	c.(2026-2028)ggC>ggT	p.G676G	HYOU1_ENST00000525859.1_Silent_p.G614G|HYOU1_ENST00000529972.1_Silent_p.G614G|HYOU1_ENST00000543287.1_3'UTR	NM_001130991.1|NM_006389.3	NP_001124463.1|NP_006380.1	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1	676						endoplasmic reticulum lumen	ATP binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(10)|prostate(1)|skin(2)	33	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		CTGGAGCGACGCCCTCAGGCC	0.612000													23	50					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70637824	70637824	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr6:70637824C>A	ENST00000322773.4	+	5	392	c.290C>A	c.(289-291)cCt>cAt	p.P97H		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	97	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						AAAGGCCTTCCTGAGGAGTAC	0.418000													5	73					1	1	1	1	0
VGLL2	245806	broad.mit.edu	37	6	117586987	117586987	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr6:117586987G>A	ENST00000326274.5	+	1	251	c.61G>A	c.(61-63)Gcc>Acc	p.A21T	VGLL2_ENST00000352536.3_Missense_Mutation_p.A21T	NM_182645.2	NP_872586.1	Q8N8G2	VGLL2_HUMAN	vestigial like 2 (Drosophila)	21					transcription, DNA-dependent	nucleus		p.A21S(1)		central_nervous_system(1)|kidney(1)|lung(3)	5				GBM - Glioblastoma multiforme(226;0.0254)|all cancers(137;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.0757)		CTTCGCAGCCGCCTACACCCC	0.582000													5	18					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5921341	5921341	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr9:5921341G>A	ENST00000399933.3	-	8	4654	c.4655C>T	c.(4654-4656)cCg>cTg	p.P1552L	KIAA2026_ENST00000381461.2_Missense_Mutation_p.P1522L	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1552										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CACTGTAGACGGAATCAGTAC	0.383000													61	91					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51955819	51955819	+	Silent	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr19:51955819C>T	ENST00000321424.3	-	7	1380	c.1314G>A	c.(1312-1314)tcG>tcA	p.S438S	SIGLEC8_ENST00000340550.5_Silent_p.S345S|SIGLEC8_ENST00000430817.1_Silent_p.S329S	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	438					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CCTCCCCTGACGAGGGGGCAA	0.577000													17	28					0	0	1	0	0
TOX4	9878	broad.mit.edu	37	14	21961062	21961062	+	Silent	SNP	T	T	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr14:21961062T>A	ENST00000405508.1	+	8	1563	c.1287T>A	c.(1285-1287)gcT>gcA	p.A429A	TOX4_ENST00000262709.3_Silent_p.A429A|TOX4_ENST00000448790.2_Silent_p.A406A			O94842	TOX4_HUMAN	TOX high mobility group box family member 4	429	Gln/Pro-rich.|Poly-Ala.					chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding	p.A429A(1)		large_intestine(8)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		CAGCAGCAGCTGCTGCTGCTG	0.582000													4	104					0	0	1	0	0
DAPK2	23604	broad.mit.edu	37	15	64275809	64275809	+	Silent	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr15:64275809C>T	ENST00000261891.3	-	2	242	c.237G>A	c.(235-237)cgG>cgA	p.R79R	DAPK2_ENST00000558482.1_5'UTR|DAPK2_ENST00000558069.1_Silent_p.R79R|DAPK2_ENST00000457488.1_Silent_p.R79R			Q9UIK4	DAPK2_HUMAN	death-associated protein kinase 2	79	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	11				LUAD - Lung adenocarcinoma(2;0.215)		GCAGCACCTGCCGCAGGATGC	0.632000													3	37					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72298681	72298681	+	RNA	SNP	G	G	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr7:72298681G>T	ENST00000438125.1	-	0	72							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										AGGAGACTAGGATCTCGGACC	0.632000													5	25					0.000274275	0.000307723	1	1	0
ITK	3702	broad.mit.edu	37	5	156638349	156638349	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr5:156638349C>T	ENST00000422843.3	+	3	447	c.295C>T	c.(295-297)Cgg>Tgg	p.R99W	CTB-4E7.1_ENST00000519375.1_RNA	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	99	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCGTGAGAGCCGGCAGCGCTG	0.493000			T	SYK	peripheral T-cell lymphoma								13	35					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1271887	1271887	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:1271887G>A	ENST00000447027.1	+	31	13844	c.13786G>A	c.(13786-13788)Gtg>Atg	p.V4596M	MUC5B_ENST00000529681.1_Missense_Mutation_p.V4593M			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4593	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACTACCAAAGTGCCGACTAC	0.657000													11	64					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152688489	152688489	+	Missense_Mutation	SNP	A	A	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr6:152688489A>T	ENST00000367255.5	-	62	10437	c.9836T>A	c.(9835-9837)gTt>gAt	p.V3279D	SYNE1_ENST00000448038.1_Missense_Mutation_p.V3286D|SYNE1_ENST00000265368.4_Missense_Mutation_p.V3279D|SYNE1_ENST00000341594.5_Missense_Mutation_p.V3318D|SYNE1_ENST00000423061.1_Missense_Mutation_p.V3286D	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3279					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTGTTCTGCAACGATTCTATC	0.443000										HNSCC(10;0.0054)			22	82					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55659088	55659088	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:55659088T>A	ENST00000449290.2	+	7	1431	c.1339T>A	c.(1339-1341)Ttt>Att	p.F447I	TRIM51_ENST00000244891.3_Missense_Mutation_p.F304I	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	447	B30.2/SPRY.					intracellular	zinc ion binding										CAGGCCTATCTTTTGCTGTAG	0.458000													23	99					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62288998	62288998	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:62288998T>A	ENST00000378024.4	-	5	13165	c.12891A>T	c.(12889-12891)aaA>aaT	p.K4297N	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4297					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CGATGTCCACTTTGGGGCCCT	0.512000													118	217					0	0	1	0	0
CNDP1	84735	broad.mit.edu	37	18	72245549	72245549	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr18:72245549C>T	ENST00000582365.1	+	8	1091	c.1025C>T	c.(1024-1026)gCg>gTg	p.A342V	CNDP1_ENST00000358821.3_Missense_Mutation_p.A385V			Q96KN2	CNDP1_HUMAN	carnosine dipeptidase 1 (metallopeptidase M20 family)	385					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		AATGTGTCTGCGGTGGAAAAA	0.443000													34	67					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123687296	123687296	+	Silent	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr6:123687296C>T	ENST00000334268.4	-	20	1622	c.1305G>A	c.(1303-1305)gcG>gcA	p.A435A	TRDN_ENST00000398178.3_Silent_p.A435A			Q13061	TRDN_HUMAN	triadin	435					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		TAATTGAAACCGCACCAATCT	0.323000													4	8					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155735541	155735541	+	Silent	SNP	G	G	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr1:155735541G>C	ENST00000437809.1	-	21	3845	c.3723C>G	c.(3721-3723)gcC>gcG	p.A1241A	GON4L_ENST00000368331.1_Silent_p.A1241A|GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000271883.5_Silent_p.A1241A|GON4L_ENST00000361040.5_Silent_p.A1241A			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1241					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGCCCTGAAAGGCATTTTCCC	0.502000													13	56					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68940103	68940103	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr10:68940103T>A	ENST00000433211.1	-	7	1193	c.1019A>T	c.(1018-1020)cAg>cTg	p.Q340L	CTNNA3_ENST00000545309.1_Missense_Mutation_p.Q340L|CTNNA3_ENST00000373744.4_Missense_Mutation_p.Q340L|CTNNA3_ENST00000494580.1_5'UTR	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	340					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						AAGCAGATCCTGAAGAGCCTG	0.498000													6	52					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134084164	134084164	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr4:134084164T>A	ENST00000264360.4	+	4	3656	c.2830T>A	c.(2830-2832)Tgt>Agt	p.C944S		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	944					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CACTGAGGAATGTAAAGCTCT	0.478000													11	58					0	0	1	0	0
RP11-1166P10.6	0	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													3	52					0	0	1	0	0
ALG8	79053	broad.mit.edu	37	11	77815429	77815429	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:77815429G>C	ENST00000376156.3	-	11	1252	c.1249C>G	c.(1249-1251)Ctc>Gtc	p.L417V	ALG8_ENST00000532552.2_5'UTR|ALG8_ENST00000299626.5_Missense_Mutation_p.L417V	NM_001007027.2	NP_001007028.1	Q9BVK2	ALG8_HUMAN	ALG8, alpha-1,3-glucosyltransferase	417					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	30	all_cancers(14;3.62e-19)|all_epithelial(13;1.27e-21)|Breast(9;8.51e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;9.66e-25)			AGAGGAAAGAGGGAATAATGT	0.378000													3	7					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20976630	20976630	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr16:20976630A>G	ENST00000261383.3	-	53	8575	c.8576T>C	c.(8575-8577)aTc>aCc	p.I2859T	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2859	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCTTTCCCGGATCCGCTTCAT	0.493000													39	90					0	0	1	0	0
KLHL26	55295	broad.mit.edu	37	19	18775073	18775073	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr19:18775073C>T	ENST00000300976.4	+	2	176	c.86C>T	c.(85-87)aCg>aTg	p.T29M	KLHL26_ENST00000595182.1_Missense_Mutation_p.T29M|KLHL26_ENST00000599006.1_Missense_Mutation_p.T29M|KLHL26_ENST00000596843.1_3'UTR	NM_018316.1	NP_060786.1	Q53HC5	KLH26_HUMAN	kelch-like family member 26	29										breast(1)|central_nervous_system(1)|kidney(1)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						CCCCGCAGCACGGCCGACAAG	0.622000													18	102					0	0	1	0	0
USP29	0	broad.mit.edu	37	19	57642355	57642355	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr19:57642355C>A	ENST00000254181.4	+	4	2766	c.2312C>A	c.(2311-2313)tCt>tAt	p.S771Y	USP29_ENST00000598197.1_Missense_Mutation_p.S771Y	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	771					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTCAATCAGTCTACAGAATTA	0.453000													4	27					0.000602214	0.000651809	1	1	0
C20orf194	25943	broad.mit.edu	37	20	3259591	3259591	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr20:3259591G>A	ENST00000252032.9	-	29	2684	c.2617C>T	c.(2617-2619)Ctc>Ttc	p.L873F	C20orf194_ENST00000453730.2_3'UTR	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	873										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						TTAGGAAAGAGAAATCTAGGG	0.368000													8	104					0	0	1	0	0
ENPP1	5167	broad.mit.edu	37	6	132207857	132207857	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr6:132207857G>T	ENST00000360971.2	+	24	2620	c.2600G>T	c.(2599-2601)aGc>aTc	p.S867I		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	867	Nuclease.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	AACAGCGAGAGCTGTGTGGTA	0.388000													6	93					0.0293803	0.0303707	1	1	0
DPY19L2	283417	broad.mit.edu	37	12	64041124	64041124	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr12:64041124A>G	ENST00000324472.4	-	5	793	c.610T>C	c.(610-612)Tgc>Cgc	p.C204R	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	204					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		ATGAATGTGCAATACCAGGAG	0.303000													4	86					0	0	1	0	0
TBC1D7	51256	broad.mit.edu	37	6	13316821	13316821	+	Silent	SNP	C	C	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr6:13316821C>A	ENST00000607658.1	-	4	570	c.420G>T	c.(418-420)cgG>cgT	p.R140R	TBC1D7_ENST00000379300.3_Silent_p.R167R|TBC1D7_ENST00000379307.2_Silent_p.R140R|TBC1D7_ENST00000356436.4_Silent_p.R167R|TBC1D7_ENST00000607532.1_5'UTR|TBC1D7_ENST00000343141.4_Intron			Q9P0N9	TBCD7_HUMAN	TBC1 domain family, member 7	167	Rab-GAP TBC.				positive regulation of protein ubiquitination	cytoplasmic membrane-bounded vesicle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)	22	Breast(50;0.0296)|Ovarian(93;0.0339)	all_hematologic(90;0.135)	Epithelial(50;0.0784)|BRCA - Breast invasive adenocarcinoma(129;0.13)|all cancers(50;0.21)			GCAAGGAATCCCGGTACTTGG	0.473000													43	87					2.13384e-23	2.54952e-23	1	1	0
FAT3	120114	broad.mit.edu	37	11	92086088	92086088	+	Silent	SNP	T	T	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:92086088T>C	ENST00000298047.6	+	1	827	c.810T>C	c.(808-810)acT>acC	p.T270T	FAT3_ENST00000409404.2_Silent_p.T270T|FAT3_ENST00000525166.1_Silent_p.T120T|FAT3_ENST00000541502.1_Silent_p.T270T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	270	Cadherin 3.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATGTAGTCACTCATGTTCCTT	0.423000										TCGA Ovarian(4;0.039)			14	84					0	0	1	0	0
SP2	6668	broad.mit.edu	37	17	45993545	45993545	+	Silent	SNP	C	C	G			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr17:45993545C>G	ENST00000376741.4	+	3	245	c.108C>G	c.(106-108)gcC>gcG	p.A36A	AC003665.1_ENST00000585280.1_RNA|AC003665.1_ENST00000433001.1_RNA|AC003665.1_ENST00000451140.2_RNA|AC003665.1_ENST00000411573.2_RNA	NM_003110.5	NP_003101.3	Q02086	SP2_HUMAN	Sp2 transcription factor	36					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	13						CTCCCTTAGCCCTGCTTGCTG	0.577000													49	175					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22855263	22855263	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr15:22855263C>A	ENST00000283645.4	+	13	1854	c.1724C>A	c.(1723-1725)gCg>gAg	p.A575E	TUBGCP5_ENST00000453949.2_Missense_Mutation_p.A575E|TUBGCP5_ENST00000559846.1_3'UTR	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	575					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		CTGCAGTGTGCGGAGAGCACC	0.562000													3	11					0.115264	0.117825	1	1	0
NR1D1	9572	broad.mit.edu	37	17	38249344	38249344	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr17:38249344C>T	ENST00000246672.3	-	8	2467	c.1837G>A	c.(1837-1839)Gcc>Acc	p.A613T	THRA_ENST00000394121.4_Silent_p.G394G|THRA_ENST00000584985.1_Intron|THRA_ENST00000264637.4_Silent_p.G394G	NM_021724.3	NP_068370.1	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	613					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|large_intestine(5)|lung(2)|skin(1)|upper_aerodigestive_tract(2)	11	Colorectal(19;0.000442)					GGTCACTGGGCGTCCACCCGG	0.592000													12	65					0	0	1	0	0
HNRNPH1	3187	broad.mit.edu	37	5	179050048	179050048	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr5:179050048C>A	ENST00000356731.5	-	1	1622	c.87G>T	c.(85-87)agG>agT	p.R29S	HNRNPH1_ENST00000510411.1_Missense_Mutation_p.R29S|HNRNPH1_ENST00000524180.1_5'UTR|HNRNPH1_ENST00000442819.2_Missense_Mutation_p.R29S|HNRNPH1_ENST00000393432.4_Missense_Mutation_p.R29S|HNRNPH1_ENST00000329433.6_Missense_Mutation_p.R29S			P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1 (H)	29	RRM 1.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|skin(1)	14						CAGAAAAAAACCTCTGCACTT	0.672000													5	18					0.000602214	0.000651809	1	1	0
AC009499.1	0	broad.mit.edu	37	2	33952672	33952672	+	RNA	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr2:33952672G>A	ENST00000366209.2	+	0	68				MYADML_ENST00000474610.1_RNA																							TGGCGTGGTCGCGGGAACGGC	0.642000													7	10					0	0	1	0	0
UBE2C	11065	broad.mit.edu	37	20	44444280	44444280	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr20:44444280A>G	ENST00000405520.1	+	3	1037	c.200A>G	c.(199-201)aAc>aGc	p.N67S	UBE2C_ENST00000496085.1_3'UTR|UBE2C_ENST00000372568.4_Missense_Mutation_p.N67S|UBE2C_ENST00000352551.5_Missense_Mutation_p.N77S|UBE2C_ENST00000335046.3_Intron|UBE2C_ENST00000356455.4_Missense_Mutation_p.N106S|UBE2C_ENST00000243893.6_Intron	NM_181802.1	NP_861518.1	O00762	UBE2C_HUMAN	ubiquitin-conjugating enzyme E2C	106					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|exit from mitosis|free ubiquitin chain polymerization|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|positive regulation of exit from mitosis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|protein K48-linked ubiquitination|spindle organization	anaphase-promoting complex|cytosol|nucleoplasm	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(2)|lung(2)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				TATCACCCCAACGTGGACACC	0.522000													21	86					0	0	1	0	0
KCNJ16	3773	broad.mit.edu	37	17	68128240	68128240	+	Silent	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr17:68128240C>T	ENST00000585558.1	+	4	505	c.117C>T	c.(115-117)taC>taT	p.Y39Y	KCNJ16_ENST00000586462.1_Silent_p.Y43Y|KCNJ16_ENST00000392670.1_Silent_p.Y4Y|KCNJ16_ENST00000283936.1_Silent_p.Y4Y|KCNJ16_ENST00000589377.1_Silent_p.Y4Y|KCNJ16_ENST00000392671.1_Silent_p.Y4Y			Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 16	4					synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	32	Breast(10;2.96e-09)					TGAGCTATTACGGCAGCAGCT	0.428000													9	38					0	0	1	0	0
ANP32A	8125	broad.mit.edu	37	15	69080172	69080172	+	Silent	SNP	T	T	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr15:69080172T>C	ENST00000465139.2	-	2	284	c.141A>G	c.(139-141)ttA>ttG	p.L47L	ANP32A_ENST00000560303.1_Silent_p.L47L|ANP32A_ENST00000483551.2_5'UTR	NM_006305.3	NP_006296.1	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	47					intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding			endometrium(1)|large_intestine(1)|lung(2)	4						TGATTGTACTTAAGAATTCCA	0.453000													36	67					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	64041106	64041106	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr12:64041106T>C	ENST00000324472.4	-	5	811	c.628A>G	c.(628-630)Atg>Gtg	p.M210V	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	210					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AATAAATTCATTATTCCCATG	0.318000													4	79					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236746154	236746154	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr1:236746154G>A	ENST00000366582.3	-	19	2558	c.2444C>T	c.(2443-2445)cCt>cTt	p.P815L	HEATR1_ENST00000366581.2_Missense_Mutation_p.P815L	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	815					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CAGTTGTTCAGGATTCCACCA	0.433000													5	30					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733808	50733808	+	Silent	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr16:50733808C>T	ENST00000300589.2	+	2	588	c.483C>T	c.(481-483)ttC>ttT	p.F161F	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	161	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				AGCGGGGTTTCGTCAGCCAGT	0.582000													7	21					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16436341	16436341	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr9:16436341C>A	ENST00000380672.4	-	6	1908	c.1851G>T	c.(1849-1851)atG>atT	p.M617I	BNC2_ENST00000380666.2_Missense_Mutation_p.M617I|BNC2_ENST00000380667.2_Missense_Mutation_p.M550I|BNC2_ENST00000545497.1_Missense_Mutation_p.M522I	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	617					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		GGGTGGCCATCATCACTGCTG	0.562000													9	51					6.42651e-13	7.48404e-13	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168102424	168102424	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr2:168102424G>T	ENST00000409195.1	+	9	4611	c.4522G>T	c.(4522-4524)Ggt>Tgt	p.G1508C	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.G1508C|XIRP2_ENST00000409273.1_Missense_Mutation_p.G1286C	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1333					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGCACATAAAGGTATCACAAA	0.388000													23	49					3.85864e-22	4.55122e-22	1	1	0
QSER1	79832	broad.mit.edu	37	11	32956318	32956318	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:32956318C>T	ENST00000399302.2	+	4	3462	c.3127C>T	c.(3127-3129)Ctt>Ttt	p.L1043F	QSER1_ENST00000527788.1_Missense_Mutation_p.L804F	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1043										breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					TAGGAGTGCACTTGCACTGTT	0.433000													4	44					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143185954	143185954	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr3:143185954G>A	ENST00000316549.6	-	12	1602	c.1394C>T	c.(1393-1395)aCg>aTg	p.T465M		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	465					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						GAGGAGCAGCGTAGTGGTAAA	0.488000													4	29					0	0	1	0	0
PCDHA10	0	broad.mit.edu	37	5	140237812	140237812	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr5:140237812G>A	ENST00000307360.5	+	1	2179	c.2179G>A	c.(2179-2181)Gag>Aag	p.E727K	PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGCCCACCGAGGGCGCATG	0.652000													4	13					0	0	1	0	0
CYP11B1	0	broad.mit.edu	37	8	143957228	143957228	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr8:143957228G>A	ENST00000292427.4	-	6	1053	c.1021C>T	c.(1021-1023)Cgc>Tgc	p.R341C	CYP11B1_ENST00000517471.1_Missense_Mutation_p.R341C|CYP11B1_ENST00000377675.3_Missense_Mutation_p.R412C	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	341					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CTCTCCTGGCGCAGGGCCTGC	0.642000									Familial Hyperaldosteronism type I				28	84					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11596383	11596383	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr1:11596383C>T	ENST00000304391.6	+	5	596	c.478C>T	c.(478-480)Cgc>Tgc	p.R160C	PTCHD2_ENST00000389575.3_Silent_p.D1273D|PTCHD2_ENST00000294484.6_Silent_p.D1273D			Q9P2K9	PTHD2_HUMAN	patched domain containing 2	0					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GCCCCCAGGACGCCCGAACGC	0.716000													9	9					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45525436	45525436	+	Silent	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr19:45525436G>A	ENST00000221452.8	+	5	780	c.630G>A	c.(628-630)gtG>gtA	p.V210V	RELB_ENST00000540120.1_Silent_p.V210V|RELB_ENST00000505236.1_Silent_p.V207V	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	210	RHD.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		TCTGCAGGGTGCGGCTCCGGC	0.652000													15	28					0	0	1	0	0
SSTR4	6754	broad.mit.edu	37	20	23016578	23016578	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr20:23016578G>A	ENST00000255008.3	+	1	522	c.458G>A	c.(457-459)cGc>cAc	p.R153H	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	153					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CACCCTCTGCGCGCGGCGACC	0.667000													13	94					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158261881	158261881	+	Silent	SNP	T	T	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr1:158261881T>C	ENST00000368170.3	+	3	615	c.336T>C	c.(334-336)ttT>ttC	p.F112F		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	112					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					CAGATCCCTTTGAAGTACAGG	0.428000													39	58					0	0	1	0	0
HSPA8	3312	broad.mit.edu	37	11	122929402	122929402	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:122929402T>C	ENST00000534624.1	-	7	1736	c.1460A>G	c.(1459-1461)aAt>aGt	p.N487S	HSPA8_ENST00000534319.1_Missense_Mutation_p.N251S|HSPA8_ENST00000533540.1_Missense_Mutation_p.N341S|HSPA8_ENST00000532636.1_Missense_Mutation_p.N487S|HSPA8_ENST00000526110.1_Missense_Mutation_p.N468S|HSPA8_ENST00000453788.2_Intron|HSPA8_ENST00000227378.3_Missense_Mutation_p.N487S	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	487					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGCAGAGACATTGAGTATACC	0.453000													19	136					0	0	1	0	0
ZNF354B	117608	broad.mit.edu	37	5	178310743	178310743	+	Silent	SNP	A	A	C	rs141045688		TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr5:178310743A>C	ENST00000322434.3	+	5	1516	c.1290A>C	c.(1288-1290)atA>atC	p.I430I		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GACACCGAATAATTCATACTG	0.353000													3	54					0	0	1	0	0
IGFBP3	3486	broad.mit.edu	37	7	45957023	45957023	+	Missense_Mutation	SNP	G	G	A	rs139238956		TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr7:45957023G>A	ENST00000275521.6	-	2	552	c.419C>T	c.(418-420)tCg>tTg	p.S140L	IGFBP3_ENST00000381086.5_Missense_Mutation_p.S43L|IGFBP3_ENST00000381083.4_Missense_Mutation_p.S146L|IGFBP3_ENST00000465642.1_5'UTR	NM_000598.4|NM_001013398.1	NP_000589.2|NP_001013416.1	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	140	Ser/Thr-rich.				negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(6)|lung(7)|pancreas(1)|prostate(3)	17					Mecasermin(DB01277)	GTCTTCCTCCGACTCACTAGC	0.502000											OREG0018049	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	27					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26825137	26825137	+	Silent	SNP	A	A	G			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr10:26825137A>G	ENST00000376236.4	+	10	1490	c.1035A>G	c.(1033-1035)ggA>ggG	p.G345G		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	345	PH.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TACCCAAAGGAAAGACTAAGG	0.328000													26	129					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84607667	84607667	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr9:84607667C>T	ENST00000344803.2	+	4	2329	c.2282C>T	c.(2281-2283)tCa>tTa	p.S761L		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		GAGAGGAGCTCAAATATGCTT	0.468000													8	27					0	0	1	0	0
SIRPB2	284759	broad.mit.edu	37	20	1457915	1457915	+	Silent	SNP	G	G	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr20:1457915G>T	ENST00000537284.1	-	5	849	c.513C>A	c.(511-513)gtC>gtA	p.V171V	SIRPB2_ENST00000444444.1_Intron|SIRPB2_ENST00000359801.3_Intron|SIRPB2_ENST00000381630.1_3'UTR			Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	0	Ig-like V-type 2.					integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CCCTTCCCATGACCAAGCCAT	0.567000													16	78					0.000308642	0.000342109	1	1	0
CCT8L2	150160	broad.mit.edu	37	22	17072764	17072764	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr22:17072764C>T	ENST00000359963.3	-	1	936	c.677G>A	c.(676-678)gGg>gAg	p.G226E		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	226					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ACAGAGCTTCCCAGATATTGC	0.607000													11	44					0	0	1	0	0
CENPT	80152	broad.mit.edu	37	16	67865131	67865131	+	Silent	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr16:67865131G>A	ENST00000562787.1	-	10	1239	c.691C>T	c.(691-693)Ctg>Ttg	p.L231L	CENPT_ENST00000440851.2_Silent_p.L231L|CENPT_ENST00000564817.1_Silent_p.L231L|CENPT_ENST00000445712.2_Silent_p.L128L|CENPT_ENST00000219172.3_Silent_p.L231L|CENPT_ENST00000562947.1_5'UTR	NM_025082.3	NP_079358.3	Q96BT3	CENPT_HUMAN	centromere protein T	231					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding			NS(1)|breast(2)|lung(6)|urinary_tract(1)	10		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		GGAGGAGCCAGGGAAGTATCT	0.602000													4	29					0	0	1	0	0
RRN3P2	0	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													6	75					0	0	1	0	0
GRIN2A	0	broad.mit.edu	37	16	9858512	9858512	+	Silent	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr16:9858512G>A	ENST00000396573.2	-	14	3198	c.2889C>T	c.(2887-2889)ctC>ctT	p.L963L	GRIN2A_ENST00000404927.2_Silent_p.L963L|GRIN2A_ENST00000562109.1_Silent_p.L963L|GRIN2A_ENST00000535259.1_Silent_p.L806L|GRIN2A_ENST00000396575.2_Silent_p.L963L|GRIN2A_ENST00000330684.3_Silent_p.L963L	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	963					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CAAATGTTTGGAGTTCGTTCA	0.443000													27	110					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37884140	37884140	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr17:37884140C>T	ENST00000406381.2	+	29	4031	c.3521C>T	c.(3520-3522)gCc>gTc	p.A1174V	ERBB2_ENST00000445658.2_Missense_Mutation_p.A928V|ERBB2_ENST00000540147.1_Missense_Mutation_p.A1174V|ERBB2_ENST00000541774.1_Missense_Mutation_p.A1189V|ERBB2_ENST00000269571.5_Missense_Mutation_p.A1204V|ERBB2_ENST00000584450.1_3'UTR|ERBB2_ENST00000584601.1_Missense_Mutation_p.A1174V	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	1204					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GGAGGAGCTGCCCCTCAGCCC	0.622000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			6	699					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179469794	179469794	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr2:179469794C>A	ENST00000589042.1	-	280	54334	c.54110G>T	c.(54109-54111)cGg>cTg	p.R18037L	TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R9097L|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R9164L|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R16396L|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R15469L|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R8972L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16396							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGTCCTCCCGGACCGCTTT	0.448000													6	128					3.59834e-05	4.087e-05	1	1	0
MYRIP	25924	broad.mit.edu	37	3	40231802	40231802	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr3:40231802A>G	ENST00000302541.6	+	10	1855	c.1513A>G	c.(1513-1515)Agg>Ggg	p.R505G	MYRIP_ENST00000444716.1_Missense_Mutation_p.R505G|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000396217.3_Missense_Mutation_p.R416G|MYRIP_ENST00000539167.1_Missense_Mutation_p.R318G|MYRIP_ENST00000425621.1_Missense_Mutation_p.R505G	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	505	Actin-binding.|Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GTTGGCCAGCAGGGAGACCTC	0.647000													9	51					0	0	1	0	0
LRP2BP	55805	broad.mit.edu	37	4	186299165	186299165	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr4:186299165G>A	ENST00000510776.1	-	0	1007				LRP2BP_ENST00000505916.1_Intron|LRP2BP_ENST00000328559.7_Intron|RP11-714G18.1_ENST00000514884.1_RNA|LRP2BP_ENST00000362004.3_Intron			Q9P2M1	LR2BP_HUMAN	LRP2 binding protein							cytoplasm	protein binding			breast(1)|endometrium(2)|large_intestine(6)|lung(3)|prostate(1)|skin(2)	15		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)		TTCTTGTCTCGTTTGCTCTAG	0.338000													3	11					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112622677	112622677	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr12:112622677G>A	ENST00000550722.1	-	61	10050	c.9655C>T	c.(9655-9657)Cgc>Tgc	p.R3219C	HECTD4_ENST00000430131.2_Missense_Mutation_p.R2943C|HECTD4_ENST00000377560.5_Missense_Mutation_p.R3193C	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GTGAGGTGGCGGAGGATGATG	0.692000													3	51					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39579113	39579113	+	Missense_Mutation	SNP	C	C	T	rs149307038	by1000genomes	TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr17:39579113C>T	ENST00000225550.3	-	3	648	c.649G>A	c.(649-651)Gcg>Acg	p.A217T	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	217	Coil 1B.|Rod.		A -> V (in dbSNP:rs16966811).			intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				GCCAGGGTCGCGTCATCCAGG	0.652000													22	21					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	115006111	115006111	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr1:115006111C>T	ENST00000358465.2	-	3	796	c.713G>A	c.(712-714)tGt>tAt	p.C238Y	TRIM33_ENST00000369543.2_Missense_Mutation_p.C238Y	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	238					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACATGTCTTACATAGCCACTC	0.343000			T	RET	papillary thyroid								29	73					0	0	1	0	0
SHANK3	85358	broad.mit.edu	37	22	51143453	51143453	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr22:51143453G>A	ENST00000414786.2	+	16	2143	c.1916G>A	c.(1915-1917)gGt>gAt	p.G639D	SHANK3_ENST00000445220.2_Missense_Mutation_p.G654D|SHANK3_ENST00000262795.3_Missense_Mutation_p.G669D			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	669										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		ATTCGCCAGGGTGGCAACCGC	0.632000													12	40					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186395542	186395542	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr3:186395542C>T	ENST00000232003.4	+	7	1528	c.1448C>T	c.(1447-1449)cCg>cTg	p.P483L		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	483	His/Pro-rich (HRR).				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		TTCCCATTGCCGCACCACAAA	0.488000													36	58					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30957343	30957343	+	Silent	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr2:30957343C>T	ENST00000295055.8	-	19	1946	c.1770G>A	c.(1768-1770)tcG>tcA	p.S590S	CAPN13_ENST00000534090.2_Silent_p.S590S	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	590					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TCCACAAGTCCGAGCTCAGGA	0.542000													3	19					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455959	5455959	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr19:5455959C>T	ENST00000222033.4	+	1	534	c.457C>T	c.(457-459)Cgc>Tgc	p.R153C		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	153	PA.					integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		ACTGGGCAACCGCTCTCTGGG	0.692000													4	36					0	0	1	0	0
UFL1	23376	broad.mit.edu	37	6	97000426	97000426	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr6:97000426T>C	ENST00000369278.4	+	18	2120	c.2054T>C	c.(2053-2055)aTt>aCt	p.I685T		NM_015323.4	NP_056138.1	O94874	UFL1_HUMAN	UFM1-specific ligase 1	685					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity										CCTGCTCTTATTCTGCACCTC	0.413000													7	40					0	0	1	0	0
ITPKC	80271	broad.mit.edu	37	19	41223697	41223697	+	Silent	SNP	T	T	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr19:41223697T>C	ENST00000263370.2	+	1	690	c.657T>C	c.(655-657)gcT>gcC	p.A219A		NM_025194.2	NP_079470.1	Q96DU7	IP3KC_HUMAN	inositol-trisphosphate 3-kinase C	219						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	14			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			AGCCAAGTGCTGATGGCTCCT	0.517000													3	20					0	0	1	0	0
HDHD2	84064	broad.mit.edu	37	18	44660924	44660924	+	Missense_Mutation	SNP	G	G	A	rs143514214	byFrequency	TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr18:44660924G>A	ENST00000300605.6	-	3	405	c.253C>T	c.(253-255)Cgg>Tgg	p.R85W	HDHD2_ENST00000587841.1_Intron	NM_032124.4	NP_115500.1	Q9H0R4	HDHD2_HUMAN	haloacid dehalogenase-like hydrolase domain containing 2	85			R -> Q (in dbSNP:rs7230131).				hydrolase activity			kidney(2)|large_intestine(2)|lung(1)|skin(1)	6						ACTTGTTTCCGCTCTAGTAAA	0.383000													3	64					0	0	1	0	0
RPL7	6129	broad.mit.edu	37	8	74203464	74203464	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr8:74203464C>G	ENST00000396467.1	-	6	580	c.442G>C	c.(442-444)Gag>Cag	p.E148Q	RPL7_ENST00000396466.1_Missense_Mutation_p.E148Q|RPL7_ENST00000396465.1_Missense_Mutation_p.E148Q|RPL7_ENST00000352983.2_Missense_Mutation_p.E188Q	NM_000971.3	NP_000962.2	P18124	RL7_HUMAN	ribosomal protein L7	188					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|mRNA binding|protein homodimerization activity|structural constituent of ribosome			breast(1)|kidney(1)|large_intestine(2)|lung(1)	5	Breast(64;0.0954)		Epithelial(68;0.0193)|all cancers(69;0.0766)|BRCA - Breast invasive adenocarcinoma(89;0.134)			ATCAAATCCTCCATGCAGATG	0.318000													7	16					0	0	1	0	0
FBXO4	26272	broad.mit.edu	37	5	41929873	41929873	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr5:41929873T>G	ENST00000296812.2	+	3	556	c.500T>G	c.(499-501)tTt>tGt	p.F167C	FBXO4_ENST00000281623.3_Missense_Mutation_p.F167C|FBXO4_ENST00000509134.1_Missense_Mutation_p.F167C	NM_033484.2	NP_277019.1	Q9UKT5	FBX4_HUMAN	F-box protein 4	167					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(11)|prostate(1)|stomach(1)|urinary_tract(2)	27		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				GTCACTTCTTTTTTACACTCC	0.393000													35	88					0	0	1	0	0
BTN3A3	10384	broad.mit.edu	37	6	26452087	26452087	+	Silent	SNP	G	G	C			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr6:26452087G>C	ENST00000244519.2	+	11	1446	c.1203G>C	c.(1201-1203)gtG>gtC	p.V401V	BTN3A3_ENST00000361232.3_Silent_p.V352V|BTN3A3_ENST00000339789.4_Silent_p.V359V	NM_006994.4	NP_008925.1	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3	401	B30.2/SPRY.					integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						AGGTGGAAGTGGGGGACAGAA	0.493000													5	38					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187070	152187070	+	Silent	SNP	C	C	T			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr1:152187070C>T	ENST00000368801.2	-	3	7110	c.7035G>A	c.(7033-7035)gaG>gaA	p.E2345E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2345					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGAGCTAGACTCGTGGTGAC	0.562000													13	1389					0	0	1	0	0
OR52L1	338751	broad.mit.edu	37	11	6007621	6007621	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:6007621C>A	ENST00000332249.4	-	1	594	c.540G>T	c.(538-540)ttG>ttT	p.L180F		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTTTTCCCAACAAAATGGGGA	0.493000													13	69					0.0167234	0.0176845	1	1	0
ASIC1	41	broad.mit.edu	37	12	50472233	50472233	+	Silent	SNP	C	C	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr12:50472233C>A	ENST00000228468.4	+	6	1252	c.867C>A	c.(865-867)acC>acA	p.T289T	ASIC1_ENST00000552438.1_Silent_p.T323T|ASIC1_ENST00000447966.2_Silent_p.T289T	NM_020039.3	NP_064423.2	P78348	ACCN2_HUMAN	acid-sensing (proton-gated) ion channel 1	289					calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	CCTGGGGCACCTGCAAAGCTG	0.592000													13	49					4.36969e-10	5.02514e-10	1	1	0
VIPR1	7433	broad.mit.edu	37	3	42569561	42569561	+	Silent	SNP	C	C	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr3:42569561C>A	ENST00000433647.1	+	7	1083	c.459C>A	c.(457-459)atC>atA	p.I153I	VIPR1-AS1_ENST00000596630.1_RNA|VIPR1-AS1_ENST00000593611.1_RNA|VIPR1-AS1_ENST00000593621.1_RNA|VIPR1_ENST00000543411.1_Silent_p.I146I|VIPR1_ENST00000438259.2_Intron|VIPR1_ENST00000325123.4_Silent_p.I194I|VIPR1-AS1_ENST00000452639.2_RNA|VIPR1-AS1_ENST00000602176.1_RNA|VIPR1-AS1_ENST00000601312.1_RNA|VIPR1-AS1_ENST00000600342.1_RNA|VIPR1-AS1_ENST00000598837.1_RNA	NM_001251882.1	NP_001238811.1	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	194					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|ovary(2)|skin(1)|urinary_tract(3)	18				KIRC - Kidney renal clear cell carcinoma(284;0.241)		CTGTCTTCATCAAAGACTTGG	0.607000													4	55					0.150653	0.152309	1	1	0
AC007563.5	0	broad.mit.edu	37	2	217648266	217648267	+	RNA	INS	-	-	A			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr2:217648266_217648267insA	ENST00000447289.1	+	0	510																											AGAGGACAGAGAAGGGACCAAG	0.505													2	4	---	---	---	---					
RP11-218D6.4	0	broad.mit.edu	37	10	28293617	28293617	+	RNA	DEL	T	T	-			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr10:28293617delT	ENST00000425137.1	+	0	111																											CTGAAGTTCATTGCCAGGACT	0.488													2	4	---	---	---	---					
FAM99B	0	broad.mit.edu	37	11	1706206	1706232	+	RNA	DEL	CCCAGGAGGGAAGGGGGTCCAGGAGGA	CCCAGGAGGGAAGGGGGTCCAGGAGGA	-	rs113543086	by1000genomes	TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:1706206_1706232delCCCAGGAGGGAAGGGGGTCCAGGAGGA	ENST00000382166.2	-	0	192					NR_026642.1																						TCCAGGAGGGCCCAGGAGGGAAGGGGGTCCAGGAGGACAGGGGGTCC	0.722													3	5	---	---	---	---					
ATM	472	broad.mit.edu	37	11	108143285	108143293	+	In_Frame_Del	DEL	TATTCTCTG	TATTCTCTG	-			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr11:108143285_108143293delTATTCTCTG	ENST00000278616.4	+	21	3489_3497	c.3104_3112delTATTCTCTG	c.(3103-3114)ata>a	p.IFSV1035del	ATM_ENST00000452508.2_In_Frame_Del_p.IFSV1035del	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1035					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGGAAATATATATTCTCTGTAAGAATGGC	0.311			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			25	72	---	---	---	---					
METTL25	84190	broad.mit.edu	37	12	82780736	82780736	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr12:82780736delC	ENST00000248306.3	+	2	483	c.414delC	c.(412-414)aafs	p.N138fs	METTL25_ENST00000547357.1_3'UTR	NM_032230.2	NP_115606.2			methyltransferase like 25																		GAAATCAAAACCAGAGAATTG	0.353													16	104	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20086382	20086383	+	RNA	INS	-	-	AAAA			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr14:20086382_20086383insAAAA	ENST00000548261.1	+	0	135																											TCTTACAAGGTAAAAAAAATGA	0.312													4	2	---	---	---	---					
LRRK1	79705	broad.mit.edu	37	15	101552216	101552218	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-ZG-A9N3-01A-11D-A41K-08	TCGA-ZG-A9N3-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58adc8fa-3f18-4834-b1b5-d45667de6d78	14a14273-2596-4f11-82ef-cdfa397cb9a3	g.chr15:101552216_101552218delTGT	ENST00000284395.5	+	11	1676_1678	c.1276_1278delTGT	c.(1276-1278)del	p.C427del	LRRK1_ENST00000388948.3_In_Frame_Del_p.C430del			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	430					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTCTTAGAAATGTTGTAAAGCTT	0.369													13	76	---	---	---	---					
